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1. Supplementary Fig. 3 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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2. Supplementary Fig. 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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3. Supplementary Table 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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4. Supplementary Fig. 5 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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5. Supplementary Fig. 4 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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6. Supplementary Table 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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7. Data from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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8. Supplementary Fig. 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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9. CCR Translation for This Article from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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10. Supplementary Figure Legends 1-3, Tables 1-3 from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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11. Supplementary Figures 1-3 from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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13. Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

Author

Iqbal, Javeed, Shen, Yulei, Huang, Xin, Liu, Yanyan, Wake, Laura, Liu, Cuiling, Deffenbacher, Karen, Lachel, Cynthia M., Wang, Chao, Rohr, Joseph, Guo, Shuangping, Smith, Lynette M., Wright, George, Bhagavathi, Sharathkumar, Dybkaer, Karen, Fu, Kai, Greiner, Timothy C., Vose, Julie M., Jaffe, Elaine, Rimsza, Lisa, Rosenwald, Andreas, Ott, German, Delabie, Jan, Campo, Elias, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Armitage, James O., Weisenburger, Dennis D., Staudt, Louis M., Gascoyne, Randy D., McKeithan, Timothy W., and Chan, Wing C.

Published
2015
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14. Automated Bright-Field Dual-Color In Situ Hybridization for MDM2: Interobserver Reproducibility and Correlation With Fluorescence In Situ Hybridization in a Series of Soft Tissue Consults

Author

Zhang, Gloria, Lanigan, Christopher P., Goldblum, John R., Tubbs, Raymond R., and Downs-Kelly, Erinn

Subjects
Oncogenes -- Health aspects -- Identification and classification, In situ hybridization -- Methods -- Usage, Health
Abstract

Context.--Atypical lipomatous tumors/well-differentiated liposarcomas contain alterations in the 12q13-15 region resulting in amplification of MDM2 and nearby genes. Identifying MDM2 amplification is a useful ancillary test, as the histologic mimics of atypical lipomatous tumors/ well-differentiated liposarcomas have consistently shown a lack of MDM2 amplification. Objective.--To assess the interobserver reproducibility of a bright-field assay for MDM2 amplification (dual-color, dual-hapten in situ hybridization [DDISH]) among reviewers with varying degrees of experience with the assay and to assess the concordance of MDM2 DDISH with MDM2 fluorescence in situ hybridization (FISH). Design.--In total, 102 cases were assessed in parallel for MDM2 by FISH and DDISH. MDM2 amplification was defined as an MDM2 to chromosome 12 ratio of 2.0 or greater, whereas an MDM2 to chromosome 12 ratio of less than 2 was nonamplified. Fluorescence in situ hybridization was scored in the routine clinical laboratory and DDISH was evaluated by 3 different pathologists blinded to the final diagnosis and FISH results. Results.--Fluorescence in situ hybridization categorized 27 cases (26%) as MDM2 amplified and 75 cases (74%) as nonamplified; the consensus DDISH diagnosis was 98% concordant with FISH. Agreement between MDM2 DDISH by each reviewer and mDM2 FISH was highly concordant (99%, 98%, and 98%, respectively, for reviewers 1, 2 and 3). The K agreement of the 3 reviewers scoring DDISH was excellent ([kappa] = 0.949, 0.95, and 0.95, respectively, for reviewers 1, 2, and 3). Conclusions.--This study highlights excellent concordance between DDISH and FISH in MDM2 copy number assessment. Moreover, excellent interobserver reproducibility of the DDISH assay was found among reviewers with varying levels of experience evaluating bright-field assays. (doi: 10.5858/arpa.2015-0249-OA), MDM2 is an oncogene that plays an important role in regulating the cell cycle and tumorigenesis by its inhibitory interaction with TP53. (1) MDM2 gene amplification has been identified in [...]

Published
2016
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15. BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma

Author

Kendrick, Samantha L., Redd, Lucas, Muranyi, Andrea, Henricksen, Leigh A., Stanislaw, Stacey, Smith, Lynette M., Perry, Anamarija M., Fu, Kai, Weisenburger, Dennis D., Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Jaffe, Elaine S., Campo, Elías, Delabie, Jan, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Staudt, Louis M., Chan, Wing Chung, Steidl, Christian, Grogan, Thomas M., and Rimsza, Lisa M.

Published
2014
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17. Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

Author

Iqbal, Javeed, Wright, George, Wang, Chao, Rosenwald, Andreas, Gascoyne, Randy D., Weisenburger, Dennis D., Greiner, Timothy C., Smith, Lynette, Guo, Shuangping, Wilcox, Ryan A., Teh, Bin Tean, Lim, Soon Thye, Tan, Soon Yong, Rimsza, Lisa M., Jaffe, Elaine S., Campo, Elias, Martinez, Antonio, Delabie, Jan, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Ott, German, Geissinger, Eva, Gaulard, Philippe, Piccaluga, Pier Paolo, Pileri, Stefano A., Au, Wing Y., Nakamura, Shigeo, Seto, Masao, Berger, Francoise, de Leval, Laurence, Connors, Joseph M., Armitage, James, Vose, Julie, Chan, Wing C., and Staudt, Louis M.

Published
2014
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23. Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis

Author

Iqbal, Javeed, Shen, Yulei, Liu, Yanyan, Fu, Kai, Jaffe, Elaine S., Liu, Cuiling, Liu, Zhongfeng, Lachel, Cynthia M., Deffenbacher, Karen, Greiner, Timothy C., Vose, Julie M., Bhagavathi, Sharathkumar, Staudt, Louis M., Rimsza, Lisa, Rosenwald, Andreas, Ott, German, Delabie, Jan, Campo, Elias, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Gascoyne, Randy D., Armitage, James O., Weisenburger, Dennis D., McKeithan, Timothy W., and Chan, Wing C.

Published
2012
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24. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

Author

Muppidi, Jagan R., Schmitz, Roland, Green, Jesse A., Xiao, Wenming, Larsen, Adrien B., Braun, Sterling E., An, Jinping, Xu, Ying, Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Braziel, Rita M., Tubbs, Raymond R., Cook, J. R., Weisenburger, Dennis D., Chan, Wing C., Vaidehi, Nagarajan, Staudt, Louis M., and Cyster, Jason G.

Subjects
Genetic research, Lymphomas -- Genetic aspects, B cells -- Physiological aspects, Cancer -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined (1,2). Work in mice showed that sphingosine-l-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells (3,4). Recent deep sequencing studies of GCB-DLBCL have revealed mutations in many genes in this cancer, including in GNA13 (encoding Gα13) and S1PR2 (refs 5-7). Here we show, using in vitro and in vivo assays, that GCBDLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor's Akt and migration inhibitory functions. Gα13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were unable to suppress pAkt and migration in response to S1P, and Gα13-deficient mice developed germinal centre B-cell-derived lymphoma. Germinal centre B cells, unlike most lymphocytes, are tightly confined in lymphoid organs and do not recirculate. Remarkably, deficiency in Gα13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and blood. GCB-DLBCL cell lines frequently carried mutations in the Gα13 effector ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination. The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13. These findings identify a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma., We sequenced the S1PR2 coding region in 117 GCB-DLBCL, 31 Burkitt's lymphoma and 68 activated B-cell-like (ABC)-DLBCL samples. Twelve S1PR2 coding mutations were identified in the GCB-DLBCL samples versus one [...]

Published
2014

39. Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features

Author

Enjuanes, Anna, Albero, Robert, Clot, Guillem, Navarro, Alba, Beà, Sílvia, Pinyol, Magda, Martín-Subero, José I., Klapper, Wolfram, Staudt, Louis M., Jaffe, Elaine S., Rimsza, Lisa, Braziel, Rita M., Delabie, Jan, Cook, James R., Tubbs, Raymond R., Gascoyne, Randy, Connors, Joseph M., Weisenburger, Dennis D., Greiner, Timothy C., Chan, Wing-Chung, López-Guillermo, Armando, Rosenwald, Andreas, Ott, German, Campo, Elías, and Jares, Pedro

Published
2013
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41. Autologous Transplantation as Consolidation for Aggressive Non-Hodgkinʼs Lymphoma

Author

Stiff, Patrick J., Unger, Joseph M., Cook, James R., Constine, Louis S., Couban, Stephen, Stewart, Douglas A., Shea, Thomas C., Porcu, Pierluigi, Winter, Jane N., Kahl, Brad S., Miller, Thomas P., Tubbs, Raymond R., Marcellus, Deborah, Friedberg, Jonathan W., Barton, Kevin P., Mills, Glenn M., LeBlanc, Michael, Rimsza, Lisa M., Forman, Stephen J., and Fisher, Richard I.

Published
2013
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49. HER-2 fluorescence in situ hybridization: results from the survey program of the College of American Pathologists

Author

Persons, Diane L., Tubbs, Raymond R., Cooley, Linda D., Dewald, Gordon W., Dowling, Patricia K., Du, Emma, Mascarello, James T., Rao, Kathleen W., Wilson, Kathleen S., Wolff, Daynna J., and Habegger-Vance, Gail

Subjects
In situ hybridization -- Usage, In situ hybridization -- Research, Fluorescence microscopy -- Methods, Fluorescence microscopy -- Usage, Breast cancer -- Diagnosis, Gene mutations -- Analysis
Published
2006

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