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1. Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study

Author

Bögemann, S. A., Riepenhausen, A., Puhlmann, L. M. C., Bar, S., Hermsen, E. J. C., Mituniewicz, J., Reppmann, Z. C., Uściƚko, A., van Leeuwen, J. M. C., Wackerhagen, C., Yuen, K. S. L., Zerban, M., Weermeijer, J., Marciniak, M. A., Mor, N., van Kraaij, A., Köber, G., Pooseh, S., Koval, P., Arias-Vásquez, A., Binder, H., De Raedt, W., Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylińska, D., Veer, I. M., Kalisch, R., Hermans, E. J., and Walter, H.

Published
2023
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12. Dynamic modelling of mental resilience in young adults: Protocol for a longitudinal observational study (DynaM-OBS)

Author

Wackerhagen, C., Veer, I.M., Leeuwen, J.M.C. van, Reppmann, Z.C., Riepenhausen, A., Bögemann, S.A., Mor, N., Puhlmann, L.M.C., Uscilko, A., Zerban, M., Mituniewicz, J., Lerner, A., Yuen, K.S.L., Köber, G., Marciniak, M.A., Pooseh, S., Weermeijer, J.D.M., Arias Vasquez, A., Binder, H., Raedt, W. de, Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylinska, D., Hermans, E.J., Kalisch, R., and Walter, H.

Subjects
Experimental Psychopathology and Treatment, 230 Affective Neuroscience
Abstract

Contains fulltext : 294461.pdf (Publisher’s version ) (Open Access) Background: Stress-related mental disorders are highly prevalent and pose a substantial burden on individuals and society. Improving strategies for the prevention and treatment of mental disorders requires a better understanding of their risk and resilience factors. This multicenter study aims to contribute to this endeavor by investigating psychological resilience in healthy but susceptible young adults over 9 months. Resilience is conceptualized in this study as the maintenance of mental health or quick recovery from mental health perturbations upon exposure to stressors, assessed longitudinally via frequent monitoring of stressors and mental health. Objective: This study aims to investigate the factors predicting mental resilience and adaptive processes and mechanisms contributing to mental resilience and to provide a methodological and evidence-based framework for later intervention studies. Methods: In a multicenter setting, across 5 research sites, a sample with a total target size of 250 young male and female adults was assessed longitudinally over 9 months. Participants were included if they reported at least 3 past stressful life events and an elevated level of (internalizing) mental health problems but were not presently affected by any mental disorder other than mild depression. At baseline, sociodemographic, psychological, neuropsychological, structural, and functional brain imaging; salivary cortisol and α-amylase levels; and cardiovascular data were acquired. In a 6-month longitudinal phase 1, stressor exposure, mental health problems, and perceived positive appraisal were monitored biweekly in a web-based environment, while ecological momentary assessments and ecological physiological assessments took place once per month for 1 week, using mobile phones and wristbands. In a subsequent 3-month longitudinal phase 2, web-based monitoring was reduced to once a month, and psychological resilience and risk factors were assessed again at the end of the 9-month period. In addition, samples for genetic, epigenetic, and microbiome analyses were collected at baseline and at months 3 and 6. As an approximation of resilience, an individual stressor reactivity score will be calculated. Using regularized regression methods, network modeling, ordinary differential equations, landmarking methods, and neural net–based methods for imputation and dimension reduction, we will identify the predictors and mechanisms of stressor reactivity and thus be able to identify resilience factors and mechanisms that facilitate adaptation to stressors. Results: Participant inclusion began in October 2020, and data acquisition was completed in June 2022. A total of 249 participants were assessed at baseline, 209 finished longitudinal phase 1, and 153 finished longitudinal phase 2. Conclusions: The Dynamic Modelling of Resilience–Observational Study provides a methodological framework and data set to identify predictors and mechanisms of mental resilience, which are intended to serve as an empirical foundation for future intervention studies. International Registered Report Identifier (IRRID): DERR1-10.2196/39817 23 p.

Published
2023

15. Pharmakogenetik in der Psychiatrie: eine Standortbestimmung

Author

Müller, D. J., Brandl, E. J., Degenhardt, F., Domschke, K., Grabe, H., Gruber, O., Hebebrand, J., Maier, W., Menke, A., Riemenschneider, M., Rietschel, M., Rujescu, D., Schulze, T. G., Tebartz van Elst, L., Tüscher, O., Deckert, J., and das DGPPN Referat Neurobiologie und Genetik

Published
2018
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16. Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: Research protocol of the DynaM-INT study

Author

Bögemann, S.A., Riepenhausen, A., Puhlmann, L.M.C., Bar, S., Hermsen, E.J.C., Mituniewicz, J., Reppmann, Z.C., Uściƚko, A., Leeuwen, J.M.C. van, Wackerhagen, C., Yuen, K.S.L., Zerban, M., Weermeijer, J., Marciniak, M.A., Mor, N., Kraaij, A. van, Kober, G., Pooseh, S., Koval, P., Arias Vasquez, A., Binder, H., Raedt, W. de, Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylinska, D., Veer, I.M., Kalisch, R., Hermans, E.J., Walter, H., Bögemann, S.A., Riepenhausen, A., Puhlmann, L.M.C., Bar, S., Hermsen, E.J.C., Mituniewicz, J., Reppmann, Z.C., Uściƚko, A., Leeuwen, J.M.C. van, Wackerhagen, C., Yuen, K.S.L., Zerban, M., Weermeijer, J., Marciniak, M.A., Mor, N., Kraaij, A. van, Kober, G., Pooseh, S., Koval, P., Arias Vasquez, A., Binder, H., Raedt, W. de, Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylinska, D., Veer, I.M., Kalisch, R., Hermans, E.J., and Walter, H.

Abstract

Contains fulltext : 295904.pdf (Publisher’s version ) (Open Access), BACKGROUND: Stress-related disorders such as anxiety and depression are highly prevalent and cause a tremendous burden for affected individuals and society. In order to improve prevention strategies, knowledge regarding resilience mechanisms and ways to boost them is highly needed. In the Dynamic Modelling of Resilience - interventional multicenter study (DynaM-INT), we will conduct a large-scale feasibility and preliminary efficacy test for two mobile- and wearable-based just-in-time adaptive interventions (JITAIs), designed to target putative resilience mechanisms. Deep participant phenotyping at baseline serves to identify individual predictors for intervention success in terms of target engagement and stress resilience. METHODS: DynaM-INT aims to recruit N = 250 healthy but vulnerable young adults in the transition phase between adolescence and adulthood (18-27 years) across five research sites (Berlin, Mainz, Nijmegen, Tel Aviv, and Warsaw). Participants are included if they report at least three negative burdensome past life events and show increased levels of internalizing symptoms while not being affected by any major mental disorder. Participants are characterized in a multimodal baseline phase, which includes neuropsychological tests, neuroimaging, bio-samples, sociodemographic and psychological questionnaires, a video-recorded interview, as well as ecological momentary assessments (EMA) and ecological physiological assessments (EPA). Subsequently, participants are randomly assigned to one of two ecological momentary interventions (EMIs), targeting either positive cognitive reappraisal or reward sensitivity. During the following intervention phase, participants' stress responses are tracked using EMA and EPA, and JITAIs are triggered if an individually calibrated stress threshold is crossed. In a three-month-long follow-up phase, parts of the baseline characterization phase are repeated. Throughout the entire study, stressor exposure and mental health are

Published
2023

17. Psychological Resilience Factors and Their Association With Weekly Stressor Reactivity During the COVID-19 Outbreak in Europe: Prospective Longitudinal Study.

Author

Bögemann, S.A., Puhlmann, L.M.C., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., Yuen, K.S.L., Pooseh, S., Marciniak, M.A., Reppmann, Z.C., Uściƚko, A., Weermeijer, J.D.M., Lenferink, D.B., Mituniewicz, J., Robak, N., Donner, N.C., Mestdagh, M., Verdonck, S., Dick, R. van, Kleim, B., Lieb, K., Leeuwen, J.M.C. van, Kobylińska, D., Myin-Germeys, I., Walter, H., Tüscher, O., Hermans, E.J., Veer, I.M., Kalisch, R., Bögemann, S.A., Puhlmann, L.M.C., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., Yuen, K.S.L., Pooseh, S., Marciniak, M.A., Reppmann, Z.C., Uściƚko, A., Weermeijer, J.D.M., Lenferink, D.B., Mituniewicz, J., Robak, N., Donner, N.C., Mestdagh, M., Verdonck, S., Dick, R. van, Kleim, B., Lieb, K., Leeuwen, J.M.C. van, Kobylińska, D., Myin-Germeys, I., Walter, H., Tüscher, O., Hermans, E.J., Veer, I.M., and Kalisch, R.

Abstract

Item does not contain fulltext, BACKGROUND: Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low "stressor reactivity" [SR]), were reported during the first wave of the COVID-19 pandemic in 2020. OBJECTIVE: Extending these findings, we here examined prospective relationships and weekly dynamics between the same RFs and SR in a longitudinal sample during the aftermath of the first wave in several European countries. METHODS: Over 5 weeks of app-based assessments, participants reported weekly stressor exposure, mental health problems, RFs, and demographic data in 1 of 6 different languages. As (partly) preregistered, hypotheses were tested cross-sectionally at baseline (N=558), and longitudinally (n=200), using mixed effects models and mediation analyses. RESULTS: RFs at baseline, including positive appraisal style (PAS), optimism (OPT), general self-efficacy (GSE), perceived good stress recovery (REC), and perceived social support (PSS), were negatively associated with SR scores, not only cross-sectionally (baseline SR scores; all P<.001) but also prospectively (average SR scores across subsequent weeks; positive appraisal (PA), P=.008; OPT, P<.001; GSE, P=.01; REC, P<.001; and PSS, P=.002). In both associations, PAS mediated the effects of PSS on SR (cross-sectionally: 95% CI -0.064 to -0.013; prospectively: 95% CI -0.074 to -0.0008). In the analyses of weekly RF-SR dynamics, the RFs PA of stressors generally and specifically related to the COVID-19 pandemic, and GSE were negatively associated with SR in a contemporaneous fashion (PA, P<.001; PAC,P=.03; and GSE, P<.001), but not in a lagged fashion (PA, P=.36; PAC, P=.52; and GSE, P=.06). CONCLUSIONS: We identified psychological RFs that prospectively predict resilience and cofluctuate with weekly SR within individuals. These prospective results endorse that the previously reported RF-SR associations do not exclusively re

Published
2023

18. Coping with COVID: risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, Walter, Henrik, Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, and Walter, Henrik

Abstract

Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M=2.45) and 2021 (M=2.21) were elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2023

19. Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study

Author

Bögemann, S A; https://orcid.org/0000-0001-9382-0769, Riepenhausen, A, Puhlmann, L M C, Bar, S, Hermsen, E J C, Mituniewicz, J, Reppmann, Z C, Uściƚko, A, van Leeuwen, J M C, Wackerhagen, C, Yuen, K S L, Zerban, M, Weermeijer, J, Marciniak, M A, Mor, N, van Kraaij, A, Köber, G, Pooseh, S, Koval, P, Arias-Vásquez, A, Binder, H, De Raedt, W, Kleim, Birgit; https://orcid.org/0000-0001-9114-2917, Myin-Germeys, I, Roelofs, K, Timmer, J, Tüscher, O, Hendler, T, Kobylińska, D, Veer, I M, et al, Bögemann, S A; https://orcid.org/0000-0001-9382-0769, Riepenhausen, A, Puhlmann, L M C, Bar, S, Hermsen, E J C, Mituniewicz, J, Reppmann, Z C, Uściƚko, A, van Leeuwen, J M C, Wackerhagen, C, Yuen, K S L, Zerban, M, Weermeijer, J, Marciniak, M A, Mor, N, van Kraaij, A, Köber, G, Pooseh, S, Koval, P, Arias-Vásquez, A, Binder, H, De Raedt, W, Kleim, Birgit; https://orcid.org/0000-0001-9114-2917, Myin-Germeys, I, Roelofs, K, Timmer, J, Tüscher, O, Hendler, T, Kobylińska, D, Veer, I M, and et al

Abstract

Background Stress-related disorders such as anxiety and depression are highly prevalent and cause a tremendous burden for affected individuals and society. In order to improve prevention strategies, knowledge regarding resilience mechanisms and ways to boost them is highly needed. In the Dynamic Modelling of Resilience – interventional multicenter study (DynaM-INT), we will conduct a large-scale feasibility and preliminary efficacy test for two mobile- and wearable-based just-in-time adaptive interventions (JITAIs), designed to target putative resilience mechanisms. Deep participant phenotyping at baseline serves to identify individual predictors for intervention success in terms of target engagement and stress resilience. Methods DynaM-INT aims to recruit N = 250 healthy but vulnerable young adults in the transition phase between adolescence and adulthood (18–27 years) across five research sites (Berlin, Mainz, Nijmegen, Tel Aviv, and Warsaw). Participants are included if they report at least three negative burdensome past life events and show increased levels of internalizing symptoms while not being affected by any major mental disorder. Participants are characterized in a multimodal baseline phase, which includes neuropsychological tests, neuroimaging, bio-samples, sociodemographic and psychological questionnaires, a video-recorded interview, as well as ecological momentary assessments (EMA) and ecological physiological assessments (EPA). Subsequently, participants are randomly assigned to one of two ecological momentary interventions (EMIs), targeting either positive cognitive reappraisal or reward sensitivity. During the following intervention phase, participants' stress responses are tracked using EMA and EPA, and JITAIs are triggered if an individually calibrated stress threshold is crossed. In a three-month-long follow-up phase, parts of the baseline characterization phase are repeated. Throughout the entire study, stressor exposure and mental health are re

Published
2023

21. Loneliness during the Covid-19 Pandemic in Germany: Impact of social factors and polygenic risk scores on interpersonal differences in loneliness and mental health

Author

von Werthern, N.M., Ahrens, K.F., Neumann, R.J., Kollmann, B., Kranz, T.M., Lieb, K., Tüscher, O., Reif, A., Fiebach, C.J., and Plichta, M.M.

Abstract

The outbreak of Covid-19 negatively affected mental health and elevated loneliness. The subjective feeling of loneliness is influenced by genetic and social factors and has a negative impact on mental health. From March 2020 to June 2021 loneliness was investigated in N = 517 individuals using monthly acquired questionnaire data and Latent Growth Curve Analysis. Three classes (“average”, 40%; “not lonely”, 38%; “elevated loneliness”, 22%) were identified, that differ significantly regarding loneliness, mental dysfunction, and response to the lockdown phases. Associations of social factors and polygenic risk scores (PRSs, n = 361) with class membership were investigated. Individuals with a high PRS for neuroticism are more likely to belong to the “elevated loneliness” class, living with another person is a protective factor. As the “ loneliness” class was at highest risk of mental dysfunction, our findings underscore the importance of identifying those individuals to implement counteractive measures.

Published
2023
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24. Coping with COVID: Risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A., Veer, I.M., Wackerhagen, C., Reppmann, Z.C., Köber, G., Ayuso-Mateos, J.L., Bögemann, S.A., Corrao, G., Felez-Nobrega, M., Abad, J.M.H., Hermans, E.J., Leeuwen, J.M.C. van, Lieb, K., Lorant, V., Mary-Krause, M., Mediavilla, R., Melchior, M., Mittendorfer-Rutz, E., Compagnoni, M.M., Pan, K.Y., Puhlmann, L.M.C., Roelofs, K., Sijbrandij, M., Smith, P., Tüscher, O., Witteveen, A.B., Zerban, M., Kalisch, R., Kröger, H., Walter, H., Riepenhausen, A., Veer, I.M., Wackerhagen, C., Reppmann, Z.C., Köber, G., Ayuso-Mateos, J.L., Bögemann, S.A., Corrao, G., Felez-Nobrega, M., Abad, J.M.H., Hermans, E.J., Leeuwen, J.M.C. van, Lieb, K., Lorant, V., Mary-Krause, M., Mediavilla, R., Melchior, M., Mittendorfer-Rutz, E., Compagnoni, M.M., Pan, K.Y., Puhlmann, L.M.C., Roelofs, K., Sijbrandij, M., Smith, P., Tüscher, O., Witteveen, A.B., Zerban, M., Kalisch, R., Kröger, H., and Walter, H.

Abstract

01 maart 2022, Item does not contain fulltext, Background: The coronavirus disease 2019 (COVID-19) pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n = 6684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress [(PD; measured via Patient Health Questionnaire for Depression and Anxiety (PHQ-4)] from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M = 2.45) and 2021 (M = 2.21) were elevated compared to 2019 (M = 1.79). Several risk factors (catastrophizing, neuroticism, and asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, and optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. A comparison of pre-pandemic data stresses the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2022

25. Coping with COVID: risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, Walter, Henrik, Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, and Walter, Henrik

Abstract

Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M=2.45) and 2021 (M=2.21) were elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2022

26. Impact of work arrangements during the COVID-19 pandemic on mental health in France.

Author

Hecker, I, El Aarbaoui, T, Wallez, S, Andersen, AJ, Ayuso-Mateos, JL, Bryant, R, Corrao, G, McDaid, D, Mediavilla, R, Mittendorfer-Rutz, E, Compagnoni, MM, Park, A-L, Riepenhausen, A, Rigotti, T, Seeber, K, Sijbrandij, M, Smith, P, Tüscher, O, Walter, H, Witteveen, A, Mary-Krause, M, Melchior, M, Hecker, I, El Aarbaoui, T, Wallez, S, Andersen, AJ, Ayuso-Mateos, JL, Bryant, R, Corrao, G, McDaid, D, Mediavilla, R, Mittendorfer-Rutz, E, Compagnoni, MM, Park, A-L, Riepenhausen, A, Rigotti, T, Seeber, K, Sijbrandij, M, Smith, P, Tüscher, O, Walter, H, Witteveen, A, Mary-Krause, M, and Melchior, M

Abstract

•Symptoms of anxiety/depression were found in 28.8% of the participants at least once.•Unemployment and financial difficulties were associated with anxiety/depression.•Targeted mental health support could lessen mental health impact.

Published
2022

27. The NUM egePan COVID-ψ-studies: offer and utilization, challenges and good-practice-solutions in the German mental health care system during the COVID-19-pandemic

Author

Wiegand, HF, Röthke, N, Gerlinger, G, Tüscher, O, Lieb, K, Heinz, A, Falkai, P, and Adorjan, K

Subjects
ddc: 610, Medicine and health
Abstract

Background: The COVID-19 pandemic poses a challenge for mental health care systems. Infections among patients and healthcare professionals pose a challenge to routine practices, elaborate protective and testing measures have to be put into place and the system has to cope with staffing shortages due [for full text, please go to the a.m. URL]

Published
2021
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28. The impact of physical fitness on resilience to modern life stress and the mediating role of general self-efficacy

Author

Neumann, R. J., primary, Ahrens, K. F., additional, Kollmann, B., additional, Goldbach, N., additional, Chmitorz, A., additional, Weichert, D., additional, Fiebach, C. J., additional, Wessa, M., additional, Kalisch, R., additional, Lieb, K., additional, Tüscher, O., additional, Plichta, M. M., additional, Reif, A., additional, and Matura, S., additional

Published
2021
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29. Weekly dynamics of stressor resilience and protective factors during the COVID-19 outbreak in Europe

Author

Bögemann, Sophie A., primary, Puhlmann, L., additional, Wackerhagen, C., additional, Zerban, M., additional, Riepenhausen, A., additional, Köber, G., additional, Yuen, K.S.L., additional, Pooseh, S., additional, Uściƚko, A., additional, Weermeijer, J., additional, Verdonck, S., additional, Mestdagh, M., additional, van Dick, R., additional, Lieb, K., additional, van Leeuwen, J.M.C., additional, Kobylinska, D., additional, Myin-Germeys, I., additional, Walter, H., additional, Tüscher, O., additional, Hermans, E.J., additional, Veer, I.M., additional, and Kalisch, R., additional

Published
2021
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32. Psycho-social factors associated with mental resilience in the Corona lockdown

Author

Veer, I.M. Riepenhausen, A. Zerban, M. Wackerhagen, C. Puhlmann, L.M.C. Engen, H. Köber, G. Bögemann, S.A. Weermeijer, J. Uściłko, A. Mor, N. Marciniak, M.A. Askelund, A.D. Al-Kamel, A. Ayash, S. Barsuola, G. Bartkute-Norkuniene, V. Battaglia, S. Bobko, Y. Bölte, S. Cardone, P. Chvojková, E. Damnjanović, K. De Calheiros Velozo, J. de Thurah, L. Deza-Araujo, Y.I. Dimitrov, A. Farkas, K. Feller, C. Gazea, M. Gilan, D. Gnjidić, V. Hajduk, M. Hiekkaranta, A.P. Hofgaard, L.S. Ilen, L. Kasanova, Z. Khanpour, M. Lau, B.H.P. Lenferink, D.B. Lindhardt, T.B. Magas, D.Á. Mituniewicz, J. Moreno-López, L. Muzychka, S. Ntafouli, M. O’Leary, A. Paparella, I. Põldver, N. Rintala, A. Robak, N. Rosická, A.M. Røysamb, E. Sadeghi, S. Schneider, M. Siugzdaite, R. Stantić, M. Teixeira, A. Todorovic, A. Wan, W.W.N. van Dick, R. Lieb, K. Kleim, B. Hermans, E.J. Kobylińska, D. Hendler, T. Binder, H. Myin-Germeys, I. van Leeuwen, J.M.C. Tüscher, O. Yuen, K.S.L. Walter, H. Kalisch, R.

Abstract

The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well as their most important risk factors have been described, hardly anything is known about potential protective factors. Resilience refers to the maintenance of mental health despite adversity. To gain mechanistic insights about the relationship between described psycho-social resilience factors and resilience specifically in the current crisis, we assessed resilience factors, exposure to Corona crisis-specific and general stressors, as well as internalizing symptoms in a cross-sectional online survey conducted in 24 languages during the most intense phase of the lockdown in Europe (22 March to 19 April) in a convenience sample of N = 15,970 adults. Resilience, as an outcome, was conceptualized as good mental health despite stressor exposure and measured as the inverse residual between actual and predicted symptom total score. Preregistered hypotheses (osf.io/r6btn) were tested with multiple regression models and mediation analyses. Results confirmed our primary hypothesis that positive appraisal style (PAS) is positively associated with resilience (p < 0.0001). The resilience factor PAS also partly mediated the positive association between perceived social support and resilience, and its association with resilience was in turn partly mediated by the ability to easily recover from stress (both p < 0.0001). In comparison with other resilience factors, good stress response recovery and positive appraisal specifically of the consequences of the Corona crisis were the strongest factors. Preregistered exploratory subgroup analyses (osf.io/thka9) showed that all tested resilience factors generalize across major socio-demographic categories. This research identifies modifiable protective factors that can be targeted by public mental health efforts in this and in future pandemics. © 2021, The Author(s).

Published
2021

40. Longitudinal determination of resilience in humans to identify mechanisms of resilience to modern-life stressors: the longitudinal resilience assessment (LORA) study

Author

Chmitorz, A., primary, Neumann, R. J., additional, Kollmann, B., additional, Ahrens, K. F., additional, Öhlschläger, S., additional, Goldbach, N., additional, Weichert, D., additional, Schick, A., additional, Lutz, B., additional, Plichta, M. M., additional, Fiebach, C. J., additional, Wessa, M., additional, Kalisch, R., additional, Tüscher, O., additional, Lieb, K., additional, and Reif, A., additional

Published
2020
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47. The resilience framework as a strategy to combat stress-related disorders

Author

Kalisch, R., Baker, D.G., Basten, U., Boks, M.P.M., Bonanno, G.A., Brummelman, E., Chmitorz, A., Fernandez, G.S.E., Fiebach, C.J., Galatzer-Levy, I.R., Geuze, E., Groppa, S., Helmreich, I., Hendler, T., Hermans, E.J., Jovanovic, T., Kubiak, T., Lieb, K., Lutz, B., Müller, M.B., Murray, R.J., Nievergelt, C.M., Reif, A., Roelofs, K., Rutten, B.P.F., Sander, D., Schick, A., Tüscher, O., Diest, I. van, Harmelen, A.L. van, Veer, I.M., Vermetten, E., Vinkers, C.H., Wager, T.D., Walter, H., Wessa, M., Wibral, M., Kleim, B., Kalisch, R., Baker, D.G., Basten, U., Boks, M.P.M., Bonanno, G.A., Brummelman, E., Chmitorz, A., Fernandez, G.S.E., Fiebach, C.J., Galatzer-Levy, I.R., Geuze, E., Groppa, S., Helmreich, I., Hendler, T., Hermans, E.J., Jovanovic, T., Kubiak, T., Lieb, K., Lutz, B., Müller, M.B., Murray, R.J., Nievergelt, C.M., Reif, A., Roelofs, K., Rutten, B.P.F., Sander, D., Schick, A., Tüscher, O., Diest, I. van, Harmelen, A.L. van, Veer, I.M., Vermetten, E., Vinkers, C.H., Wager, T.D., Walter, H., Wessa, M., Wibral, M., and Kleim, B.

Abstract

Item does not contain fulltext, Consistent failure over the past few decades to reduce the high prevalence of stress-related disorders has motivated a search for alternative research strategies. Resilience refers to the phenomenon of many people maintaining mental health despite exposure to psychological or physical adversity. Instead of aiming to understand the pathophysiology of stress-related disorders, resilience research focuses on protective mechanisms that shield people against the development of such disorders and tries to exploit its insights to improve treatment and, in particular, disease prevention. To fully harness the potential of resilience research, a critical appraisal of the current state of the art - in terms of basic concepts and key methods - is needed. We highlight challenges to resilience research and make concrete conceptual and methodological proposals to improve resilience research. Most importantly, we propose to focus research on the dynamic processes of successful adaptation to stressors in prospective longitudinal studies.

Published
2017

48. Response inhibition and its inhibitory network. fMRI differentiates inhibitory and attentional regions during response inhibition - key information for precise neurosurgery

Author

Neuhoff, Jonathan, Sebastian, A., Jung, P., Mobascher, A., Giese, Alf, and Tüscher, O.

Subjects
ddc: 610, Response Inhibition, mental disorders, fMRI, DBS, 610 Medical sciences, Medicine
Abstract

Objective: “Response inhibition” characterizes the ability to supress an initiated motor action. Dysfunction of response inhibition is seen in many psychiatric diseases, like addictive disorders, attention deficit/ hyperactive disorders, schizophrenia, bipolar disorders and others.[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016

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