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8. Diagnosis and treatment of taste disorders in Japan.

Author

Nin, Tomomi and Tsuzuki, Kenzo

Subjects
*TASTE disorders, *OLDER people, *OLDER patients, *OFF-label use (Drugs), *ZINC acetate, *DIAGNOSIS
Abstract

Though 270,000 patients with complaints of taste abnormalities visited medical institutions annually in 2019 survey, there are no drugs for the treatment of taste disorders that are covered by health insurance in Japan. In the survey, the number of patients with taste disorders was correlated with age, and the need for medical treatment for taste disorders is expected to increase in the future because of the super-aging society. The pathophysiology of taste disorders varies widely. There is an obvious need to decide the site and the causes of the disorder and understand the mechanism, by performing various examinations. It needs to first adjust the causative systemic diseases and medications in the treatment for taste disorder. Damage of taste cells due to zinc deficiency is the main pathophysiological mechanism of taste disorders, and zinc supplementation is a standard treatment in Japan. Oral zinc therapy is the treatment for taste disorders due to zinc deficiency or idiopathic taste disorder; though a double-blind study was conducted, it was considered low-level evidence in a clinical review. In Japan, the off-label use of polaprezinc for taste disorders was approved in 2011, and zinc acetate hydrate was approved for hypozincemia in March 2017, making it easier to use oral zinc therapy in general. In some cases, psychotherapy or herbal medicine therapy has been used with remarkable success, although its effectiveness has not been clearly tested. It might be expected to offer some help to patients. In the treatment of elderly patients with taste disorders, physicians need to consider the difference between "age-related changes in taste in healthy people" and "taste disorders in elderly persons", and they should separate them. Aggressive treatment is desirable regardless of age, because no significant difference in the efficacy of various treatments was found between patients older and younger than 65 years. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Usefulness of post-operative endoscopic score for optimal treatment selection in recurrent eosinophilic chronic rhinosinusitis.

Author

Saito, Takahiro, Okazaki, Ken, Fushimi, Katsuya, and Tsuzuki, Kenzo

Subjects
THERAPEUTIC use of monoclonal antibodies, STEROID drugs, CHRONIC diseases, ENDOSCOPIC surgery, PATIENT selection, RETROSPECTIVE studies, EOSINOPHILIA, DISEASE relapse, TREATMENT effectiveness, SINUSITIS, POSTOPERATIVE period, DESCRIPTIVE statistics, ENDOSCOPY
Abstract

Objective: This study retrospectively analysed post-operative endoscopic scores to determine the optimal post-operative treatment in patients with eosinophilic chronic rhinosinusitis undergoing functional endoscopic sinus surgery. Methods: In total, 339 adults who underwent initial bilateral functional endoscopic sinus surgery for eosinophilic chronic rhinosinusitis were enrolled. Patients were divided into group A, which required no additional post-operative treatment; group B, which required local/systemic steroids post-operatively; and group C, which further required dupilumab and/or revision surgery. Results: Sixty-five per cent of patients could be treated with initial functional endoscopic sinus surgery (group A). Post-operative steroids were required in 35 per cent of patients with a post-operative endoscopic score of 30 per cent (group B). Further advanced treatments with dupilumab and/or revision functional endoscopic sinus surgery were required in 10 per cent of patients with a post-operative endoscopic score of 65 per cent (group C). Conclusion: The post functional endoscopic sinus surgery endoscopic score can be used as an index to determine treatment at the time of eosinophilic chronic rhinosinusitis recurrence. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Efficacy of tokishakuyakusan and mecobalamin on post-infectious olfactory dysfunction: A prospective multicenter study

Author

Kobayashi, Masayoshi, primary, Miwa, Takaki, additional, Mori, Eri, additional, Shiga, Hideaki, additional, Tsuzuki, Kenzo, additional, Okutani, Fumino, additional, Hayama, Masaki, additional, Akazawa, Hitoshi, additional, Nakamura, Yosuke, additional, Suzuki, Motohiko, additional, Matsuwaki, Yoshinori, additional, Ogino, Eriko, additional, Shikina, Takashi, additional, Ikeda, Katsuhisa, additional, Hyo, Yukiyoshi, additional, Kashiwagi, Takashi, additional, Kondo, Kenji, additional, Shibata, Minori, additional, and Ueno, Takayoshi, additional

Published
2023
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15. 喉頭神経鞘腫例

Author

Shiono, Hiroaki, primary, Terada, Tomonori, additional, Uwa, Nobuhiro, additional, Kida, Kota, additional, Shinoda, Yuichiro, additional, Yamanegi, Koji, additional, and Tsuzuki, Kenzo, additional

Published
2023
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20. Distribution of periodontopathic bacterial species between saliva and tonsils.

Author

Nomura, Ryota, Nagasawa, Yasuyuki, Misaki, Taro, Ito, Seigo, Naka, Shuhei, Okunaka, Mieko, Watanabe, Maiko, Tsuzuki, Kenzo, Matsumoto-Nakano, Michiyo, and Nakano, Kazuhiko

Subjects
TONSILS, TONSILLITIS, SALIVA, PORPHYROMONAS gingivalis, POLYMERASE chain reaction, BACTERIAL cell surfaces, SPECIES
Abstract

Periodontopathic bacteria cause an inflammatory disease localized in the periodontal tissue and are associated with various conditions in other body parts. The distribution of periodontopathic bacterial species in the tonsils is unknown, even though the tonsils are located close to the oral cavity, and inflammation of the tonsils causes various systemic diseases. We detected the major periodontopathic bacterial species residing in saliva and tonsil specimens from 25 subjects undergoing tonsillectomy. Nine of the ten major periodontopathic bacterial species were detected by polymerase chain reaction of tonsil specimens, among which Campylobacter rectus was the most common (80.0%), followed by Porphyromonas gingivalis (36.0%). The other seven types of periodontopathic bacterial species were distributed with 0% to 25.0% abundance in the tonsil specimens. C. rectus had a high detection rate in tonsil specimens (> 75.0%), regardless of whether it was detected in the corresponding saliva specimens. However, the detection rate for P. gingivalis in tonsil specimens was significantly higher in subjects with P. gingivalis-positive saliva (77.8%) than in those with P. gingivalis-negative saliva (6.3%; P < 0.001). Furthermore, 75.0% of P. gingivalis in tonsil specimens did not have the known fimA gene that encodes the 41-kDa filamentous appendage protein FimA, which is expressed on the cell surface of the bacteria. Our results suggest that certain periodontopathic bacterial species are detected in the tonsils either independently of or depending on their distribution in the oral cavity and may be involved in tonsil-related diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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22. sj-pdf-2-ajr-10.1177_19458924211009429 - Supplemental material for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis

Author

Takabayashi, Tetsuji, Asaka, Daiya, Okamoto, Yoshitaka, Himi, Tetsuo, Haruna, Shinichi, Yoshida, Naohiro, Kondo, Kenji, Yoshikawa, Mamoru, Sakuma, Yasunori, Shibata, Kunihiko, Suzuki, Motohiko, Kobayashi, Masayoshi, Kawata, Ryo, Tsuzuki, Kenzo, Okano, Mitsuhiro, Higaki, Takaya, Takeno, Sachio, Kodama, Satoru, Yonekura, Syuji, Saito, Hiromi, Nozaki, Akiyo, Otori, Nobuyoshi, and Fujieda, Shigeharu

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract

Supplemental material, sj-pdf-2-ajr-10.1177_19458924211009429 for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis by Tetsuji Takabayashi MD, Daiya Asaka MD, Yoshitaka Okamoto MD, Tetsuo Himi MD, Shinichi Haruna MD, Naohiro Yoshida MD, Kenji Kondo MD, Mamoru Yoshikawa MD, Yasunori Sakuma MD, Kunihiko Shibata MD, Motohiko Suzuki MD, Masayoshi Kobayashi MD, Ryo Kawata MD, Kenzo Tsuzuki MD, Mitsuhiro Okano MD, Takaya Higaki MD, Sachio Takeno MD, Satoru Kodama MD, Syuji Yonekura MD, Hiromi Saito MS, Akiyo Nozaki BS, Nobuyoshi Otori MD, Shigeharu Fujieda MD in American Journal of Rhinology & Allergy

Published
2022
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23. sj-pdf-1-ajr-10.1177_19458924211009429 - Supplemental material for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis

Author

Takabayashi, Tetsuji, Asaka, Daiya, Okamoto, Yoshitaka, Himi, Tetsuo, Haruna, Shinichi, Yoshida, Naohiro, Kondo, Kenji, Yoshikawa, Mamoru, Sakuma, Yasunori, Shibata, Kunihiko, Suzuki, Motohiko, Kobayashi, Masayoshi, Kawata, Ryo, Tsuzuki, Kenzo, Okano, Mitsuhiro, Higaki, Takaya, Takeno, Sachio, Kodama, Satoru, Yonekura, Syuji, Saito, Hiromi, Nozaki, Akiyo, Otori, Nobuyoshi, and Fujieda, Shigeharu

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract

Supplemental material, sj-pdf-1-ajr-10.1177_19458924211009429 for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis by Tetsuji Takabayashi MD, Daiya Asaka MD, Yoshitaka Okamoto MD, Tetsuo Himi MD, Shinichi Haruna MD, Naohiro Yoshida MD, Kenji Kondo MD, Mamoru Yoshikawa MD, Yasunori Sakuma MD, Kunihiko Shibata MD, Motohiko Suzuki MD, Masayoshi Kobayashi MD, Ryo Kawata MD, Kenzo Tsuzuki MD, Mitsuhiro Okano MD, Takaya Higaki MD, Sachio Takeno MD, Satoru Kodama MD, Syuji Yonekura MD, Hiromi Saito MS, Akiyo Nozaki BS, Nobuyoshi Otori MD, Shigeharu Fujieda MD in American Journal of Rhinology & Allergy

Published
2022
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28. Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species

Author

Nagasawa, Yasuyuki, primary, Nomura, Ryota, additional, Misaki, Taro, additional, Ito, Seigo, additional, Naka, Shuhei, additional, Wato, Kaoruko, additional, Okunaka, Mieko, additional, Watabe, Maiko, additional, Fushimi, Katsuya, additional, Tsuzuki, Kenzo, additional, Matsumoto-Nakano, Michiyo, additional, and Nakano, Kazuhiko, additional

Published
2021
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30. A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis

Author

Takabayashi, Tetsuji, primary, Asaka, Daiya, additional, Okamoto, Yoshitaka, additional, Himi, Tetsuo, additional, Haruna, Shinichi, additional, Yoshida, Naohiro, additional, Kondo, Kenji, additional, Yoshikawa, Mamoru, additional, Sakuma, Yasunori, additional, Shibata, Kunihiko, additional, Suzuki, Motohiko, additional, Kobayashi, Masayoshi, additional, Kawata, Ryo, additional, Tsuzuki, Kenzo, additional, Okano, Mitsuhiro, additional, Higaki, Takaya, additional, Takeno, Sachio, additional, Kodama, Satoru, additional, Yonekura, Syuji, additional, Saito, Hiromi, additional, Nozaki, Akiyo, additional, Otori, Nobuyoshi, additional, and Fujieda, Shigeharu, additional

Published
2021
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43. Clinical practice guidelines for the management of olfactory dysfunction — Secondary publication

Author

Miwa, Takaki, primary, Ikeda, Katsuhisa, additional, Ishibashi, Takuya, additional, Kobayashi, Masayoshi, additional, Kondo, Kenji, additional, Matsuwaki, Yoshinori, additional, Ogawa, Takao, additional, Shiga, Hideaki, additional, Suzuki, Motohiko, additional, Tsuzuki, Kenzo, additional, Furuta, Atsuko, additional, Motoo, Yoshiharu, additional, Fujieda, Shigeharu, additional, and Kurono, Yuichi, additional

Published
2019
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48. Evaluation of a Simplified Nasal Symptoms Questionnaire

Author

Okazaki, Ken, primary, Tsuzuki, Kenzo, additional, Hashimoto, Kengo, additional, Takebayashi, Hironori, additional, Oka, Hideki, additional, Kojima, Yusuke, additional, Yukitatsu, Yoriko, additional, Mishiro, Yasuo, additional, and Sakagami, Masafumi, additional

Published
2017
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