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335 results on '"Tsutsumi, Ryosuke"'

7. Prognostic Factors after Surgical Treatment for Spinal Metastases.

Author

Murotani, Kazuhiro, Fujibayashi, Shunsuke, Otsuki, Bungo, Shimizu, Takayoshi, Sono, Takashi, Onishi, Eijiro, Kimura, Hiroaki, Tamaki, Yasuyuki, Tsubouchi, Naoya, Ota, Masato, Tsutsumi, Ryosuke, Ishibe, Tatsuya, and Matsuda, Shuichi

Subjects
PROGNOSIS, SPINAL surgery, RADIOTHERAPY, PROPORTIONAL hazards models, SPINAL cord compression, OVERALL survival, SURGICAL indications
Abstract

Study Design: A retrospective multicenter case series was conducted. Purpose: This study aimed to investigate survival and prognostic factors after surgery for a metastatic spinal tumor. Overview of Literature: Prognostic factors after spinal metastasis surgery remain controversial. Methods: A retrospective multicenter study was conducted. The study participants included 345 patients who underwent surgery for spinal metastases from 2010 to 2020 at nine referral spine centers in Japan. Data for each patient were extracted from medical records. To identify the factors predicting survival prognosis after surgery, univariate analyses were performed using a Cox proportional hazards model. Results: The mean age was 65.9 years. Common primary tumors were lung (n=72), prostate (n=61), and breast (n=39), and 67.8% (n=234) presented with osteolytic lesions. The epidural spinal cord compression scale score 2 or 3 was recognized in 79.0% (n=271). Frankel grade A paralysis accounted for 1.4% (n=5), and 73.3% (n=253) were categorized as intermediate or high risk according to the new Katagiri score. The overall survival rates were -71.0% at 6 months, 57.4% at 12, and 43.3% at 24. In the univariate analysis, Frankel grade A (hazard ratio [HR], 3.59; 95% confidence interval [CI], 1.23–10.50; p<0.05), intermediate risk (HR, 3.34; 95% CI, 2.10–5.32; p<0.01), and high risk (HR, 7.77; 95% CI, 4.72–12.8; p<0.01) in the new Katagiri score were significantly associated with poor survival. On the contrary, postoperative chemotherapy (HR, 0.23; 95% CI, 0.15–0.36; p<0.01), radiation therapy (HR, 0.43; 95% CI, 0.26–0.70; p<0.01), and both adjuvant therapy (HR, 0.21; 95% CI, 0.14–0.32; p<0.01) were suggested to improve survival. Conclusions: Surgical indications for patients with Frankel grade A or intermediate or high risk in the new Katagiri score should be carefully considered because of poor survival. Chemotherapy or radiation therapy should be considered after surgery for better survival. [ABSTRACT FROM AUTHOR]

Published
2024
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10. The evolution of surgical treatment for gastrointestinal cancers

Author

Maehara, Yoshihiko, Soejima, Yuji, Yoshizumi, Tomoharu, Kawahara, Naoyuki, Oki, Eiji, Saeki, Hiroshi, Akahoshi, Tomohiko, Ikegami, Toru, Yamashita, Yo-ichi, Furuyama, Tadashi, Sugimachi, Keishi, Harada, Noboru, Tagawa, Tetsuzo, Harimoto, Norifumi, Itoh, Shinji, Sonoda, Hideto, Ando, Koji, Nakashima, Yuichiro, Nagao, Yoshihiro, Yamashita, Nami, Kasagi, Yuta, Yukaya, Takafumi, Kurihara, Takeshi, Tsutsumi, Ryosuke, Takamori, Shinkichi, Sasaki, Shun, Ikeda, Tetsuo, Yonemitsu, Yoshikazu, Fukuhara, Takasuke, Kitao, Hiroyuki, Iimori, Makoto, Kataoka, Yuki, Wakasa, Takeshi, Suzuki, Masami, Teraishi, Koji, Yoshida, Yasuto, and Mori, Masaki

Published
2019
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19. Distant lymph node metastases caused by esophageal cancer invasion to the lamina propria: a case report

Author

Tsutsumi, Satoshi, Saeki, Hiroshi, Nakashima, Yuichiro, Nakaji, Yu, Kudou, Kensuke, Tsutsumi, Ryosuke, Nishimura, Sho, Akiyama, Shingo, Tajiri, Hirotada, Yukaya, Takafumi, Tanaka, Kimihiro, Nakanishi, Ryota, Sugiyama, Masahiko, Ohgaki, Kippei, Sonoda, Hideto, Hirahashi, Minako, Oki, Eiji, Morita, Masaru, Oda, Yoshinao, and Maehara, Yoshihiko

Published
2016
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20. Development of fistula between esophagogastric anastomotic site and cartilage portion of trachea after subtotal esophagectomy for cervical esophageal cancer: a case report

Author

Taniguchi, Daisuke, Saeki, Hiroshi, Nakashima, Yuichiro, Tsutsumi, Ryosuke, Nishimura, Sho, Kudou, Kensuke, Nakaji, Yu, Tajiri, Hirotada, Tsutsumi, Satoshi, Yukaya, Takafumi, Nakanishi, Ryota, Sugiyama, Masahiko, Sonoda, Hideto, Ohgaki, Kippei, Oki, Eiji, and Maehara, Yoshihiko

Published
2016
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26. Clinicopathological Features of Cervical Esophageal Cancer: Retrospective Analysis of 63 Consecutive Patients Who Underwent Surgical Resection

Author

Saeki, Hiroshi, Tsutsumi, Satoshi, Yukaya, Takafumi, Tajiri, Hirotada, Tsutsumi, Ryosuke, Nishimura, Sho, Nakaji, Yu, Kudou, Kensuke, Akiyama, Shingo, Kasagi, Yuta, Nakashima, Yuichiro, Sugiyama, Masahiko, Sonoda, Hideto, Ohgaki, Kippei, Oki, Eiji, Yasumatsu, Ryuji, Nakashima, Torahiko, Morita, Masaru, and Maehara, Yoshihiko

Published
2017
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29. Expeditious Access to the B3NO2Heterocycle Enabling Modular Derivatization

Author

Tsutsumi, Ryosuke, Kashiwagi, Nobuaki, and Kumagai, Naoya

Abstract

DATB (1,3-dioxa-5-aza-2,4,6-triborinane) is a unique six-membered heterocycle exhibiting proficient catalytic activity in direct dehydrative amidation. Reported herein is an improved synthetic protocol for DATB derivatives featuring a concise two-step chromatography-free process. Suzuki–Miyaura coupling assembled 2,6-dibromoaniline derivatives and 1,2-phenylenediboronic acid to afford dimeric B-spiroborate salts. Acidic untying of the spiroborates gave rise to the DATB ring system with various substituents.

Published
2023
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42. Catalyst‐Dependent Rate‐Determining Steps in Regiodivergent Vinylogous Aza‐Morita‐Baylis‐Hillman Reactions with N‐Ts Imines.

Author

Gondo, Naruhiro, Hyakutake, Ryuichi, Fujimura, Koki, Ueda, Yoshihiro, Nakano, Katsuhiko, Tsutsumi, Ryosuke, Yamanaka, Masahiro, and Kawabata, Takeo

Subjects
CATALYSTS, IMINES, KINETIC isotope effects
Abstract

Catalyst‐controlled vinylogous aza‐MBH reactions of vinylcyclopentenone were performed, and it was found that the α‐adducts were exclusively obtained by DABCO‐catalysis, while the γ‐adducts were the major products by DMAP‐catalysis. We report here that the rate‐determining step of the DABCO‐catalyzed α‐selective reactions is the Mannich‐type C−C bond forming step, while that of the DMAP‐catalyzed γ‐selective reactions seems to be the β‐elimination step. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Chiral Bipyridine Ligand with Flexible Molecular Recognition Site: Development and Application to Copper‐Catalyzed Asymmetric Borylation of α,β‐Unsaturated Ketones.

Author

Tsutsumi, Ryosuke, Taguchi, Rika, and Yamanaka, Masahiro

Subjects
*BIPYRIDINE, *BORYLATION, *KETONES, *CARBONYL compounds, *HYDROGEN bonding, *COPPER catalysts, *MOLECULAR recognition
Abstract

A novel chiral bipyridine ligand bearing a flexible side chain with a molecular recognition site enables precise stereocontrol through the cooperative action of metal center and hydrogen bonds. This new chiral ligand was applied to the copper‐catalyzed asymmetric borylation of α,β‐unsaturated carbonyl compounds. The reaction afforded the corresponding borylated products in good yields with high enantioselectivities. Preliminary studies of the functional group‐selective transformation revealed that the newly designed chiral bipyridine ligand has the potential to control chemo‐ and site selectivity in addition to stereoselectivity. [ABSTRACT FROM AUTHOR]

Published
2022
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