Author: "Tsushima F" - Searchworks@Jio Institute Digital Library Search Results

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103 results on '"Tsushima F"'

1. Clinical significance of α2,3-sialylated prostate-specific antigen density and MRI for high-grade prostate cancer in biopsy-naïve men with elevated PSA level.

Author: Yoneyama, T., primary, Yamamoto, H., additional, Sutoh Yoneyama, M., additional, Tobisawa, Y., additional, Hatakeyama, S., additional, Narita, T., additional, Kodama, H., additional, Momota, M., additional, Ito, H., additional, Narita, S., additional, Tsushima, F., additional, Mitsuzuka, K., additional, Yoneyama, T., additional, Hashimoto, Y., additional, Duivenvoorden, W., additional, Pinthus, J.H., additional, Kakeda, S., additional, Ito, A., additional, Tsuchiya, N., additional, Habuchi, T., additional, and Ohyama, C., additional
Published: 2022
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2. A case of upper gingiva carcinoma with chronic graft-versus-host disease after allogenic bone marrow transplantation

Author: Tsushima, F, Sakurai, J, and Harada, H
Published: 2015
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3. CREATION OF HIGH DEFINITION MAP FOR AUTONOMOUS DRIVING

Author: Tsushima, F., primary, Kishimoto, N., additional, Okada, Y., additional, and Che, W., additional
Published: 2020
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4. Expression and Regulation of Human CD275 on Endothelial Cells in Healthy and Inflamed Mucosal Tissues

Author: Youngnak-Piboonratanakit, P., Tsushima, F., Otsuki, N., Igarashi, H., Omura, K., and Azuma, M.
Published: 2006

5. Diagnosis of clinical subtypes of oral pemphigus by detection of desmoglein 1 and 3 autoantibodies in serum

Author: Takahashi, Y., Tsushima, F., Mogi, S., Pornpan, Y., Higashinakagawa, M., Takahashi, E., Arikawa, Y., Shiraki, R., and Enomoto, S.
Published: 2001

6. The Super-Kamiokande detector

Author: Fukuda, S., Fukuda, Y., Hayakawa, T., Ichihara, E., Ishitsuka, M., Itow, Y., Kajita, T., Kameda, J., Kaneyuki, K., Kasuga, S., Kobayashi, K., Kobayashi, Y., Koshio, Y., Miura, M., Moriyama, S., Nakahata, M., Nakayama, S., Namba, T., Obayashi, Y., Okada, A., Oketa, M., Okumura, K., Oyabu, T., Sakurai, N., Shiozawa, M., Suzuki, Y., Takeuchi, Y., Toshito, T., Totsuka, Y., Yamada, S., Desai, S., Earl, M., Hong, J.T., Kearns, E., Masuzawa, M., Messier, M.D., Stone, J.L., Sulak, L.R., Walter, C.W., Wang, W., Scholberg, K., Barszczak, T., Casper, D., Liu, D.W., Gajewski, W., Halverson, P.G., Hsu, J., Kropp, W.R., Mine, S., Price, L.R., Reines, F., Smy, M., Sobel, H.W., Vagins, M.R., Ganezer, K.S., Keig, W.E., Ellsworth, R.W., Tasaka, S., Flanagan, J.W., Kibayashi, A., Learned, J.G., Matsuno, S., Stenger, V.J., Hayato, Y., Ishii, T., Ichikawa, A., Kanzaki, J., Kobayashi, T., Maruyama, T., Nakamura, K., Oyama, Y., Sakai, A., Sakuda, M., Sasaki, O., Echigo, S., Iwashita, T., Kohama, M., Suzuki, A.T., Hasegawa, M., Inagaki, T., Kato, I., Maesaka, H., Nakaya, T., Nishikawa, K., Yamamoto, S., Haines, T.J., Kim, B.K., Sanford, R., Svoboda, R., Blaufuss, E., Chen, M.L., Conner, Z., Goodman, J.A., Guillian, E., Sullivan, G.W., Turcan, D., Habig, A., Ackerman, M., Goebel, F., Hill, J., Jung, C.K., Kato, T., Kerr, D., Malek, M., Martens, K., Mauger, C., McGrew, C., Sharkey, E., Viren, B., Yanagisawa, C., Doki, W., Inaba, S., Ito, K., Kirisawa, M., Kitaguchi, M., Mitsuda, C., Miyano, K., Saji, C., Takahata, M., Takahashi, M., Higuchi, K., Kajiyama, Y., Kusano, A., Nagashima, Y., Nitta, K., Takita, M., Yamaguchi, T., Yoshida, M., Kim, H.I., Kim, S.B., Yoo, J., Okazawa, H., Etoh, M., Fujita, K., Gando, Y., Hasegawa, A., Hasegawa, T., Hatakeyama, S., Inoue, K., Ishihara, K., Iwamoto, T., Koga, M., Nishiyama, I., Ogawa, H., Shirai, J., Suzuki, A., Takayama, T., Tsushima, F., Koshiba, M., Ichikawa, Y., Hashimoto, T., Hatakeyama, Y., Koike, M., Horiuchi, T., Nemoto, M., Nishijima, K., Takeda, H., Fujiyasu, H., Futagami, T., Ishino, H., Kanaya, Y., Morii, M., Nishihama, H., Nishimura, H., Suzuki, T., Watanabe, Y., Kielczewska, D., Golebiewska, U., Berns, H.G., Boyd, S.B., Doyle, R.A., George, J.S., Stachyra, A.L., Wai, L.L., Wilkes, R.J., Young, K.K., and Kobayashi, H.
Published: 2003
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7. P1.05-21 CT-Guided Biopsy of Lung Lesions with Outer Cannula Washing Cytology

Author: Tsushima, F., primary, Kakehata, S., additional, Miura, H., additional, Ono, S., additional, and Aoki, M., additional
Published: 2018
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8. Neutrino-induced upward stopping muons in Super-Kamiokande

Author: Fukuda, Y., Ishihara, K., Itow, Y., Kajita, T., Kameda, J., Kasuga, S., Kobayashi, K., Kobayashi, Y., Koshio, Y., Miura, M., Nakahata, M., Nakayama, S., Obayashi, Y., Okada, A., Okumura, K., Sakurai, N., Shiozawa, M., Suzuki, Y., Takeuchi, H., Takeuchi, Y., Totsuka, Y., Yamada, S., Earl, M., Habig, A., Kearns, E., Messier, M.D., Scholberg, K., Stone, J.L., Sulak, L.R., Walter, C.W., Goldhaber, M., Barszczak, T., Casper, D., Gajewski, W., Kropp, W.R., Mine, S., Price, L.R., Smy, M., Sobel, H.W., Vagins, M.R., Ganezer, K.S., Keig, W.E., Ellsworth, R.W., Tasaka, S., Kibayashi, A., Learned, J.G., Matsuno, S., Stenger, V.J., Takemori, D., Ishii, T., Ishino, H., Kobayashi, T., Nakamura, K., Oyama, Y., Sakai, A., Sakuda, M., Sasaki, O., Echigo, S., Kohama, M., Suzuki, A.T., Inagaki, T., Nishikawa, K., Haines, T.J., Blaufuss, E., Kim, B.K., Sanford, R., Svoboda, R., Chen, M.L., Goodman, J.A., Sullivan, G.W., Hill, J., Jung, C.K., Martens, K., Mauger, C., McGrew, C., Sharkey, E., Viren, B., Yanagisawa, C., Doki, W., Kirisawa, M., Inaba, S., Miyano, K., Okazawa, H., Saji, C., Takahashi, M., Takahata, M., Higuchi, K., Nagashima, Y., Takita, M., Yamaguchi, T., Yoshida, M., Kim, S.B., Etoh, M., Hasegawa, A., Hasegawa, T., Hatakeyama, S., Inoue, K., Iwamoto, T., Koga, M., Maruyama, T., Ogawa, H., Shirai, J., Suzuki, A., Tsushima, F., Koshiba, M., Hatakeyama, Y., Koike, M., Nemoto, M., Nishijima, K., Fujiyasu, H., Futagami, T., Hayato, Y., Kanaya, Y., Kaneyuki, K., Watanabe, Y., Kielczewska, D., George, J.S., Stachyra, A.L., Wilkes, R.J., and Young, K.K.
Published: 1999
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9. Measurement of radon concentrations at Super-Kamiokande

Author: Takeuchi, Y, Okumura, K, Kajita, T, Tasaka, S, Nemoto, M, Fukuda, Y, Okazawa, H, Hayakawa, T, Ishihara, K, Ishino, H, Itow, Y, Kameda, J, Kasuga, S, Kobayashi, K, Kobayashi, Y, Koshio, Y, Miura, M, Nakahata, M, Nakayama, S, Obayashi, Y, Okada, A, Sakurai, N, Shiozawa, M, Suzuki, Y, Takeuchi, H, Totsuka, Y, Yamada, S, Earl, M, Habig, A, Kearns, E, Messier, M.D, Scholberg, K, Stone, J.L, Sulak, L.R, Walter, C.W, Goldhaber, M, Barszczak, T, Casper, D, Gajewski, W, Kropp, W.R, Mine, S, Price, L.R, Smy, M, Sobel, H.W, Vagins, M.R, Ganezer, K.S, Keig, W.E, Ellsworth, R.W, Kibayashi, A, Learned, J.G, Matsuno, S, Stenger, V.J, Takemori, D, Ishii, T, Kanzaki, J, Kobayashi, T, Nakamura, K, Nishikawa, K, Oyama, Y, Sakai, A, Sakuda, M, Sasaki, O, Echigo, S, Kohama, M, Suzuki, A.T, Haines, T.J, Blaufuss, E, Kim, B.K, Sanford, R, Svoboda, R, Chen, M.L, Goodman, J.A, Sullivan, G.W, Hill, J, Jung, C.K, Martens, K, Mauger, C, McGrew, C, Sharkey, E, Viren, B, Yanagisawa, C, Doki, W, Kirisawa, M, Inaba, S, Miyano, K, Saji, C, Takahashi, M, Takahata, M, Higuchi, K, Nagashima, Y, Takita, M, Yamaguchi, T, Yoshida, M, Kim, S.B, Etoh, M, Hasegawa, A, Hasegawa, T, Hatakeyama, S, Inoue, K, Iwamoto, T, Koga, M, Maruyama, T, Ogawa, H, Shirai, J, Suzuki, A, Tsushima, F, Koshiba, M, Hatakeyama, Y, Koike, M, Nishijima, K, Fujiyasu, H, Futagami, T, Hayato, Y, Kanaya, Y, Kaneyuki, K, Watanabe, Y, Kielczewska, D, George, J.S, Stachyra, A.L, Wai, L.L, Wilkes, R.J, and Young, K.K
Published: 1999
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10. Calibration of Super-Kamiokande using an electron LINAC: The Super-Kamiokande Collaboration

Author: Nakahata, M, Fukuda, Y, Hayakawa, T, Ichihara, E, Inoue, K, Ishihara, K, Ishino, H, Itow, Y, Kajita, T, Kameda, J, Kasuga, S, Kobayashi, K, Kobayashi, Y, Koshio, Y, Martens, K, Miura, M, Nakayama, S, Okada, A, Okumura, K, Sakurai, N, Shiozawa, M, Suzuki, Y, Takeuchi, Y, Totsuka, Y, Yamada, S, Earl, M, Habig, A, Kearns, E, Messier, M.D, Scholberg, K, Stone, J.L, Sulak, L.R, Walter, C.W, Goldhaber, M, Barszczak, T, Casper, D, Gajewski, W, Halverson, P.G, Hsu, J, Kropp, W.R, Price, L.R, Reines, F, Smy, M, Sobel, H.W, Vagins, M.R, Ganezer, K.S, Keig, W.E, Ellsworth, R.W, Tasaka, S, Flanagan, J.W, Kibayashi, A, Learned, J.G, Matsuno, S, Stenger, V.J, Takemori, D, Ishii, T, Kanzaki, J, Kobayashi, T, Mine, S, Nakamura, K, Nishikawa, K, Oyama, Y, Sakai, A, Sakuda, M, Sasaki, O, Echigo, S, Kohama, M, Suzuki, A.T, Haines, T.J, Blaufuss, E, Kim, B.K, Sanford, R, Svoboda, R, Chen, M.L, Conner, Z, Goodman, J.A, Sullivan, G.W, Hill, J, Jung, C.K, Mauger, C, McGrew, C, Sharkey, E, Viren, B, Yanagisawa, C, Doki, W, Miyano, K, Okazawa, H, Saji, C, Takahata, M, Nagashima, Y, Takita, M, Yamaguchi, T, Yoshida, M, Kim, S.B, Etoh, M, Fujita, K, Hasegawa, A, Hasegawa, T, Hatakeyama, S, Iwamoto, T, Koga, M, Maruyama, T, Ogawa, H, Shirai, J, Suzuki, A, Tsushima, F, Koshiba, M, Nemoto, M, Nishijima, K, Futagami, T, Hayato, Y, Kanaya, Y, Kaneyuki, K, Watanabe, Y, Kielczewska, D, Doyle, R.A, George, J.S, Stachyra, A.L, Wai, L.L, Wilkes, R.J, Young, K.K, and Kobayashi, H
Published: 1999
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11. Search for Proton Decay through p → νK+ in a Large Water Cherenkov Detector

Author: Inoue, K., Etoh, M., Hasegawa, A., Hasegawa, T., Hatakeyama, S., Iwamoto, T., Koga, M., Maruyama, T., Ogawa, H., Shirai, J., Suzuki, A., Tsushima, F., et, al., and The Super-Kamiokande Collaboration
Published: 1999

12. Treatment of Superior Vena Cava Syndrome: Efficacy of Radiation Therapy Depends on Histopathology of Underlying Tumors

Author: Abe, Y., primary, Ohata, T., additional, Ono, S., additional, Aoki, M., additional, Miura, H., additional, Nagahata, M., additional, Hatayama, Y., additional, Tsushima, F., additional, Morimoto, K., additional, and Kawaguchi, H., additional
Published: 2008
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13. Search for Proton Decay throughp→ν¯K+in a Large Water Cherenkov Detector

Author: Hayato, Y., primary, Earl, M., additional, Fukuda, Y., additional, Hayakawa, T., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Okada, A., additional, Okumura, K., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, H., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Casper, D., additional, Gajewski, W., additional, Kropp, W. R., additional, Mine, S., additional, Price, L. R., additional, Smy, M., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V. J., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Kim, B. K., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Kirisawa, M., additional, Inaba, S., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahashi, M., additional, Takahata, M., additional, Higuchi, K., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Shirai, J., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Hatakeyama, Y., additional, Koike, M., additional, Nemoto, M., additional, Nishijima, K., additional, Fujiyasu, H., additional, Futagami, T., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, George, J. S., additional, Stachyra, A. L., additional, Wai, L. L., additional, Wilkes, R. J., additional, and Young, K. K., additional
Published: 1999
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14. Observation of the East-West Anisotropy of the Atmospheric Neutrino Flux

Author: Futagami, T., primary, Fukuda, Y., additional, Hayakawa, T., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Obayashi, Y., additional, Okada, A., additional, Okumura, K., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, H., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Casper, D., additional, Gajewski, W., additional, Kropp, W. R., additional, Mine, S., additional, Price, L. R., additional, Smy, M., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V. J., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Kim, B. K., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Kirisawa, M., additional, Inaba, S., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahashi, M., additional, Takahata, M., additional, Higuchi, K., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Shirai, J., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Hatakeyama, Y., additional, Koike, M., additional, Nemoto, M., additional, Nishijima, K., additional, Fujiyasu, H., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, George, J. S., additional, Stachyra, A. L., additional, Wai, L. L., additional, Wilkes, R. J., additional, and Young, K. K., additional
Published: 1999
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15. Measurement of the Flux and Zenith-Angle Distribution of Upward Throughgoing Muons by Super-Kamiokande

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Okumura, K., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Casper, D., additional, Gajewski, W., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Smy, M., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V. J., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Mine, S., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Kim, B. K., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Shirai, J., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R. A., additional, George, J. S., additional, Stachyra, A. L., additional, Wai, L. L., additional, Wilkes, R. J., additional, and Young, K. K., additional
Published: 1999
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16. Measurement of the Solar Neutrino Energy Spectrum Using Neutrino-Electron Scattering

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Okumura, K., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Casper, D., additional, Gajewski, W., additional, Halverson, P. G., additional, Hsu, J., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Smy, M., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V. J., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Mine, S., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Kim, B. K., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Conner, Z., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Shirai, J., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R. A., additional, George, J. S., additional, Stachyra, A. L., additional, Wai, L. L., additional, Wilkes, R. J., additional, and Young, K. K., additional
Published: 1999
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17. Constraints on Neutrino Oscillation Parameters from the Measurement of Day-Night Solar Neutrino Fluxes at Super-Kamiokande

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Okumura, K., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Casper, D., additional, Gajewski, W., additional, Halverson, P. G., additional, Hsu, J., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Smy, M., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V. J., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Mine, S., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Kim, B. K., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Conner, Z., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasagawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Shirai, J., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R. A., additional, George, J. S., additional, Stachyra, A. L., additional, Wai, L. L., additional, Wilkes, R. J., additional, and Young, K. K., additional
Published: 1999
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18. Erratum: Measurements of the Solar Neutrino Flux from Super-Kamiokande's First 300 Days [Phys. Rev. Lett. 81, 1158 (1998)]

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Martens, K., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Oketa, M., additional, Okumura, K., additional, Ota, M., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Hong, J. T., additional, Kearns, E., additional, Kim, S. B., additional, Masuzawa, M., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Gajewski, W., additional, Halverson, P. G., additional, Hsu, J., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Conner, Z., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Mori, M., additional, Hill, J., additional, Jung, C. K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Ishizuka, T., additional, Kitaguchi, Y., additional, Koga, H., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Kusano, A., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Kinebuchi, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R., additional, George, J., additional, Stachyra, A., additional, Wai, L., additional, Wilkes, J., additional, and Young, K., additional
Published: 1998
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19. Search for Proton Decay viap→e+π0in a Large Water Cherenkov Detector

Author: Shiozawa, M., primary, Viren, B., additional, Fukuda, Y., additional, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Oketa, M., additional, Okumura, K., additional, Ota, M., additional, Sakurai, N., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Gajewski, W., additional, Halverson, P. G., additional, Hsu, J., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Conner, Z., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Mori, M., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Yanagisawa, C., additional, Doki, W., additional, Ishizuka, T., additional, Kitaguchi, Y., additional, Koga, H., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Kusano, A., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Kinebuchi, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R., additional, George, J., additional, Stachyra, A., additional, Wai, L., additional, Wilkes, J., additional, and Young, K., additional
Published: 1998
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20. Study of the atmospheric neutrino flux in the multi-GeV energy range

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Martens, K., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Oketa, M., additional, Okumura, K., additional, Ota, M., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Kim, S.B., additional, Messier, M.D., additional, Scholberg, K., additional, Stone, J.L., additional, Sulak, L.R., additional, Walter, C.W., additional, Goldhaber, M., additional, Barszczak, T., additional, Gajewski, W., additional, Halverson, P.G., additional, Hsu, J., additional, Kropp, W.R., additional, Price, L.R., additional, Reines, F., additional, Sobel, H.W., additional, Vagins, M.R., additional, Ganezer, K.S., additional, Keig, W.E., additional, Ellsworth, R.W., additional, Tasaka, S., additional, Flanagan, J.W., additional, Kibayashi, A., additional, Learned, J.G., additional, Matsuno, S., additional, Stenger, V., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A.T., additional, Haines, T.J., additional, Blaufuss, E., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M.L., additional, Conner, Z., additional, Goodman, J.A., additional, Sullivan, G.W., additional, Mori, M., additional, Hill, J., additional, Jung, C.K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Ishizuka, T., additional, Kitaguchi, Y., additional, Koga, H., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Kusano, A., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Kinebuchi, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R., additional, George, J., additional, Stachyra, A., additional, Wai, L., additional, Wilkes, J., additional, and Young, K., additional
Published: 1998
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21. Evidence for Oscillation of Atmospheric Neutrinos

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Okumura, K., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Kearns, E., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczxak, T., additional, Casper, D., additional, Gajewski, W., additional, Halverson, P. G., additional, Hsu, J., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Smy, M., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V. J., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Mine, S., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Kim, B. K., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Conner, Z., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Hill, J., additional, Jung, C. K., additional, Martens, K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Kim, S. B., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Shirai, J., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R. A., additional, George, J. S., additional, Stachyra, A. L., additional, Wai, L. L., additional, Wilkes, R. J., additional, and Young, K. K., additional
Published: 1998
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22. Measurements of the Solar Neutrino Flux from Super-Kamiokande's First 300 Days

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Martens, K., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Oketa, M., additional, Okumura, K., additional, Ota, M., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Hong, J. T., additional, Kearns, E., additional, Kim, S. B., additional, Masuzawa, M., additional, Messier, M. D., additional, Scholberg, K., additional, Stone, J. L., additional, Sulak, L. R., additional, Walter, C. W., additional, Goldhaber, M., additional, Barszczak, T., additional, Gajewski, W., additional, Halverson, P. G., additional, Hsu, J., additional, Kropp, W. R., additional, Price, L. R., additional, Reines, F., additional, Sobel, H. W., additional, Vagins, M. R., additional, Ganezer, K. S., additional, Keig, W. E., additional, Ellsworth, R. W., additional, Tasaka, S., additional, Flanagan, J. W., additional, Kibayashi, A., additional, Learned, J. G., additional, Matsuno, S., additional, Stenger, V., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A. T., additional, Haines, T. J., additional, Blaufuss, E., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M. L., additional, Conner, Z., additional, Goodman, J. A., additional, Sullivan, G. W., additional, Mori, M., additional, Hill, J., additional, Jung, C. K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Ishizuka, T., additional, Kitaguchi, Y., additional, Koga, H., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Kusano, A., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Kinebuchi, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R., additional, George, J., additional, Stachyra, A., additional, Wai, L., additional, Wilkes, J., additional, and Young, K., additional
Published: 1998
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23. Measurement of a small atmospheric ν/ν ratio

Author: Fukuda, Y., primary, Hayakawa, T., additional, Ichihara, E., additional, Inoue, K., additional, Ishihara, K., additional, Ishino, H., additional, Itow, Y., additional, Kajita, T., additional, Kameda, J., additional, Kasuga, S., additional, Kobayashi, K., additional, Kobayashi, Y., additional, Koshio, Y., additional, Martens, K., additional, Miura, M., additional, Nakahata, M., additional, Nakayama, S., additional, Okada, A., additional, Oketa, M., additional, Okumura, K., additional, Ota, M., additional, Sakurai, N., additional, Shiozawa, M., additional, Suzuki, Y., additional, Takeuchi, Y., additional, Totsuka, Y., additional, Yamada, S., additional, Earl, M., additional, Habig, A., additional, Hong, J.T., additional, Kearns, E., additional, Kim, S.B., additional, Masuzawa, M., additional, Messier, M.D., additional, Scholberg, K., additional, Stone, J.L., additional, Sulak, L.R., additional, Walter, C.W., additional, Goldhaber, M., additional, Barszczak, T., additional, Gajewski, W., additional, Halverson, P.G., additional, Hsu, J., additional, Kropp, W.R., additional, Price, L.R., additional, Reines, F., additional, Sobel, H.W., additional, Vagins, M.R., additional, Ganezer, K.S., additional, Keig, W.E., additional, Ellsworth, R.W., additional, Tasaka, S., additional, Flanagan, J.W., additional, Kibayashi, A., additional, Learned, J.G., additional, Matsuno, S., additional, Stenger, V., additional, Takemori, D., additional, Ishii, T., additional, Kanzaki, J., additional, Kobayashi, T., additional, Nakamura, K., additional, Nishikawa, K., additional, Oyama, Y., additional, Sakai, A., additional, Sakuda, M., additional, Sasaki, O., additional, Echigo, S., additional, Kohama, M., additional, Suzuki, A.T., additional, Haines, T.J., additional, Blaufuss, E., additional, Sanford, R., additional, Svoboda, R., additional, Chen, M.L., additional, Conner, Z., additional, Goodman, J.A., additional, Sullivan, G.W., additional, Mori, M., additional, Goebel, F., additional, Hill, J., additional, Jung, C.K., additional, Mauger, C., additional, McGrew, C., additional, Sharkey, E., additional, Viren, B., additional, Yanagisawa, C., additional, Doki, W., additional, Ishizuka, T., additional, Kitaguchi, Y., additional, Koga, H., additional, Miyano, K., additional, Okazawa, H., additional, Saji, C., additional, Takahata, M., additional, Kusano, A., additional, Nagashima, Y., additional, Takita, M., additional, Yamaguchi, T., additional, Yoshida, M., additional, Etoh, M., additional, Fujita, K., additional, Hasegawa, A., additional, Hasegawa, T., additional, Hatakeyama, S., additional, Iwamoto, T., additional, Kinebuchi, T., additional, Koga, M., additional, Maruyama, T., additional, Ogawa, H., additional, Saito, M., additional, Suzuki, A., additional, Tsushima, F., additional, Koshiba, M., additional, Nemoto, M., additional, Nishijima, K., additional, Futagami, T., additional, Hayato, Y., additional, Kanaya, Y., additional, Kaneyuki, K., additional, Watanabe, Y., additional, Kielczewska, D., additional, Doyle, R., additional, George, J., additional, Stachyra, A., additional, Wai, L., additional, Wilkes, J., additional, and Young, K., additional
Published: 1998
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24. Incidence of unilateral distal vertebral artery aplasia: evaluation by combining basiparallel anatomic scanning-magnetic resonance imaging (BPAS-MRI) and magnetic resonance angiography.

Author: Morimoto K, Nagahata M, Ono S, Miura H, Tsushima F, Seino H, Kakehata S, Basaki K, Uno S, Abe Y, Morimoto, Kohei, Nagahata, Morio, Ono, Shuichi, Miura, Hiroyuki, Tsushima, Fumiyasu, Seino, Hiroko, Kakehata, Shinya, Basaki, Kiyoshi, Uno, Seiyu, and Abe, Yoshinao
Abstract: Purpose: The incidence of a unilateral aplastic distal vertebral artery (VA) has been reported as 0.2% of cases on cerebral angiography. During our daily magnetic resonance (MR) examinations, however, we frequently encounter MR angiograms (MRAs) that do not demonstrate unilateral VA. The purpose of this study was to calculate the frequency of aplastic unilateral distal VA by MR images performed for asymptomatic people.Materials and Methods: Over a time span of 1 year, 237 asymptomatic people (140 men, 97 women; ages 28-67 years, mean 54.4 years) underwent brain MRI during a "brain check-up examination" in our hospital. To identify an aplastic unilateral distal VA, we retrospectively compared three-dimensional time-of-flight MRA with basiparallel anatomic scanning (BPAS)-MRI which was designed for recognition of the arterial outer contour.Results: Aplasia of the unilateral distal VA was confirmed in 11 persons (4.6%). According to our classification, hypoplastic distal VA in 12 (5.1%) and asymptomatic acquired unilateral distal VA occlusion was also proved in 2 (0.8%).Conclusion: We found that the frequency of aplastic unilateral VA was 4.6% in asymptomatic people using a combination of MRA and BPAS-MRI for assessment of an intracranial VA. [ABSTRACT FROM AUTHOR]
Published: 2009
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25. Measurement of a small atmospheric νμ/ νe ratio

Author: Fukuda, Y., Hayakawa, T., Ichihara, E., Inoue, K., Ishihara, K., Ishino, H., Itow, Y., Kajita, T., Kameda, J., Kasuga, S., Kobayashi, K., Kobayashi, Y., Koshio, Y., Martens, K., Miura, M., Nakahata, M., Nakayama, S., Okada, A., Oketa, M., Okumura, K., Ota, M., Sakurai, N., Shiozawa, M., Suzuki, Y., Takeuchi, Y., Totsuka, Y., Yamada, S., Earl, M., Habig, A., Hong, J.T., Kearns, E., Kim, S.B., Masuzawa, M., Messier, M.D., Scholberg, K., Stone, J.L., Sulak, L.R., Walter, C.W., Goldhaber, M., Barszczak, T., Gajewski, W., Halverson, P.G., Hsu, J., Kropp, W.R., Price, L.R., Reines, F., Sobel, H.W., Vagins, M.R., Ganezer, K.S., Keig, W.E., Ellsworth, R.W., Tasaka, S., Flanagan, J.W., Kibayashi, A., Learned, J.G., Matsuno, S., Stenger, V., Takemori, D., Ishii, T., Kanzaki, J., Kobayashi, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakai, A., Sakuda, M., Sasaki, O., Echigo, S., Kohama, M., Suzuki, A.T., Haines, T.J., Blaufuss, E., Sanford, R., Svoboda, R., Chen, M.L., Conner, Z., Goodman, J.A., Sullivan, G.W., Mori, M., Goebel, F., Hill, J., Jung, C.K., Mauger, C., McGrew, C., Sharkey, E., Viren, B., Yanagisawa, C., Doki, W., Ishizuka, T., Kitaguchi, Y., Koga, H., Miyano, K., Okazawa, H., Saji, C., Takahata, M., Kusano, A., Nagashima, Y., Takita, M., Yamaguchi, T., Yoshida, M., Etoh, M., Fujita, K., Hasegawa, A., Hasegawa, T., Hatakeyama, S., Iwamoto, T., Kinebuchi, T., Koga, M., Maruyama, T., Ogawa, H., Saito, M., Suzuki, A., Tsushima, F., Koshiba, M., Nemoto, M., Nishijima, K., Futagami, T., Hayato, Y., Kanaya, Y., Kaneyuki, K., Watanabe, Y., Kielczewska, D., Doyle, R., George, J., Stachyra, A., Wai, L., Wilkes, J., and Young, K.
Published: 1998
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26. A0482 - Clinical significance of α2,3-sialylated prostate-specific antigen density and MRI for high-grade prostate cancer in biopsy-naïve men with elevated PSA level.

Author: Yoneyama, T., Yamamoto, H., Sutoh Yoneyama, M., Tobisawa, Y., Hatakeyama, S., Narita, T., Kodama, H., Momota, M., Ito, H., Narita, S., Tsushima, F., Mitsuzuka, K., Hashimoto, Y., Duivenvoorden, W., Pinthus, J.H., Kakeda, S., Ito, A., Tsuchiya, N., Habuchi, T., and Ohyama, C.
Subjects: *PROSTATE-specific antigen, *PROSTATE cancer patients, *PROSTATE cancer, *MAGNETIC resonance imaging, *DENSITY
Published: 2022
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27. Thin-slice Two-dimensional T2-weighted Imaging with Deep Learning-based Reconstruction: Improved Lesion Detection in the Brain of Patients with Multiple Sclerosis.

Author: Iwamura M, Ide S, Sato K, Kakuta A, Tatsuo S, Nozaki A, Wakayama T, Ueno T, Haga R, Kakizaki M, Yokoyama Y, Yamauchi R, Tsushima F, Shibutani K, Tomiyama M, and Kakeda S
Subjects: Humans, Magnetic Resonance Imaging methods, Brain diagnostic imaging, Brain pathology, Neuroimaging methods, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis pathology, Deep Learning
Abstract: Purpose: Brain MRI with high spatial resolution allows for a more detailed delineation of multiple sclerosis (MS) lesions. The recently developed deep learning-based reconstruction (DLR) technique enables image denoising with sharp edges and reduced artifacts, which improves the image quality of thin-slice 2D MRI. We, therefore, assessed the diagnostic value of 1 mm-slice-thickness 2D T2-weighted imaging (T2WI) with DLR (1 mm T2WI with DLR) compared with conventional MRI for identifying MS lesions., Methods: Conventional MRI (5 mm T2WI, 2D and 3D fluid-attenuated inversion recovery) and 1 mm T2WI with DLR (imaging time: 7 minutes) were performed in 42 MS patients. For lesion detection, two neuroradiologists counted the MS lesions in two reading sessions (conventional MRI interpretation with 5 mm T2WI and MRI interpretations with 1 mm T2WI with DLR). The numbers of lesions per region category (cerebral hemisphere, basal ganglia, brain stem, cerebellar hemisphere) were then compared between the two reading sessions., Results: For the detection of MS lesions by 2 neuroradiologists, the total number of detected MS lesions was significantly higher for MRI interpretation with 1 mm T2WI with DLR than for conventional MRI interpretation with 5 mm T2WI (765 lesions vs. 870 lesions at radiologist A, < 0.05). In particular, of the 33 lesions in the brain stem, radiologist A detected 21 (63.6%) additional lesions by 1 mm T2WI with DLR., Conclusion: Using the DLR technique, whole-brain 1 mm T2WI can be performed in about 7 minutes, which is feasible for routine clinical practice. MRI with 1 mm T2WI with DLR enabled increased MS lesion detection, particularly in the brain stem.
Published: 2024
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28. Personal immune profiles: Diversity and prognostic value for oral tongue squamous cell carcinoma evaluated by comprehensive immune parameter analyses with multiplex immunofluorescence.

Author: Daroonpan P, Ouchi R, Zhang C, Nagai S, Nishii N, Kashima Y, Tsushima F, Harada H, Hamagaki M, Ikeda T, Aida J, Kaomongkolgit R, and Azuma M
Subjects: Humans, Prognosis, Squamous Cell Carcinoma of Head and Neck metabolism, Programmed Cell Death 1 Receptor metabolism, Fluorescent Antibody Technique, Forkhead Transcription Factors metabolism, Tumor Microenvironment, B7-H1 Antigen metabolism, Lymphocytes, Tumor-Infiltrating, Carcinoma, Squamous Cell metabolism, Tongue Neoplasms metabolism, Head and Neck Neoplasms metabolism
Abstract: Objectives: Understanding the tumor immune microenvironment is becoming increasingly necessary for risk prediction and treatment selection. In particular, oral cancer has various immunosuppressive characteristics in the tumor microenvironment. Therefore, we comprehensively assessed the immune profiles of oral tongue squamous cell carcinoma (OTSCC)., Materials and Methods: Multiplex immunofluorescence and tissue imaging analyses were performed to evaluate immune profiles at the invasive tumor front of 60 OTSCC surgical specimens. We analyzed 58 immune parameters including the density and proportion (%) of total leukocytes (Leu) and T cells, six subsets of T and myeloid cells, and the expression of programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1)., Results: The density, proportion, and location of CD45 + Leu, three T cell subsets (CD8 + , Foxp3 - CD4 + conventional, and Foxp3 + CD4 + regulatory T cells), CD163 - CD68 + M1 and CD163 + CD68 + M2 macrophages, and neutrophils were highly variable at the individual level. The density and proportion of M2 macrophages were significantly lower in the T1 stage group. Risk prediction analyses for recurrence and/or metastasis (R/M) showed that R/M (+) T1 cases had significantly higher M2 density and percentages., Conclusions: The immune profiles of OTSCC patients are diverse and cannot be predicted from clinicopathological information alone. The M2 macrophage abundance is a potential candidate biomarker for R/M in the early stage of OTSCC. Personal immune profiling may provide beneficial information for risk prediction and treatment selection., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Published: 2023
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29. Association of prediabetes with reduced brain volume in a general elderly Japanese population.

Author: Tatsuo S, Watanabe K, Ide S, Tsushima F, Tatsuo S, Matsuzaka M, Murakami H, Ishida M, Iwane T, Daimon M, Yodono H, Nakaji S, and Kakeda S
Subjects: Aged, Female, Humans, Male, Blood Glucose metabolism, Cross-Sectional Studies, East Asian People, Brain diagnostic imaging, Brain pathology, Diabetes Mellitus epidemiology, Diabetes Mellitus, Type 2 pathology, Hyperglycemia complications, Hyperglycemia pathology, Prediabetic State blood, Prediabetic State complications, Prediabetic State epidemiology
Abstract: Objectives: Diabetes frequently results in cognitive impairment, but it is less clear if brain health is adversely affected during the prediabetic stage. Our aim is to identify possible changes in brain volume as measured by magnetic resonance imaging (MRI) in a large elderly population stratified according to level of "dysglycemia.", Methods: This is a cross-sectional study of 2144 participants (median age 69 years, 60.9% female) who underwent 3-T brain MRI. Participants were divided into 4 dysglycemia groups based on HbA1c levels (%): normal glucose metabolism (NGM) (< 5.7%), prediabetes (5.7 to < 6.5%), undiagnosed diabetes (6.5% or higher), and known diabetes (defined by self-report)., Results: Of the 2144 participants, 982 had NGM, 845 prediabetes, 61 undiagnosed diabetes, and 256 known diabetes. After adjustment for age, sex, education, body weight, cognitive status, smoking, drinking, and disease history, total gray matter volume was significantly lower among participants with prediabetes (0.41% lower, standardized β = - 0.0021 [95% CI - 0.0039, - 0.00039], p = 0.016), undiagnosed diabetes (1.4% lower, standardized β = - 0.0069 [95% CI - 0.012, - 0.002], p = 0.005), and known diabetes (1.1% lower, standardized β = - 0.0055 [95% CI - 0.0081, - 0.0029], p < 0.001) compared to the NGM group. After adjustment, total white matter volume and hippocampal volume did not differ significantly between the NGM group and either the prediabetes group or the diabetes group., Conclusion: Sustained hyperglycemia may have deleterious effects on gray matter integrity even prior to the onset of clinical diabetes., Key Points: • Sustained hyperglycemia has deleterious effects on gray matter integrity even prior to the onset of clinical diabetes., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)
Published: 2023
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30. Improved visualization of the subthalamic nucleus on synthetic MRI with optimized parameters: initial study.

Author: Tatsuo S, Tatsuo S, Tsushima F, Sakashita N, Oyu K, Ide S, and Kakeda S
Subjects: Humans, Magnetic Resonance Imaging methods, Brain pathology, Subthalamic Nucleus diagnostic imaging, Subthalamic Nucleus pathology, Deep Brain Stimulation methods, Parkinson Disease diagnostic imaging
Abstract: Background: Synthetic magnetic resonance imaging (SyMRI) enables to reformat various images by adjusting the MR parameters., Purpose: To investigate whether customization of the repetition time (TR), echo time (TE), and inversion time (TI) in SyMRI could improve the visualization of subthalamic nucleus (STN)., Material and Methods: We examined five healthy volunteers using both coronal SyMRI and quantitative susceptibility mapping (QSM), seven patients with Parkinson's disease (PD) using coronal SyMRI, and 15 patients with PD using coronal QSM. Two neuroradiologists reformatted SyMRI (optimized SyMRI) by adjusting TR, TE, and TI to achieve maximum tissue contrast between the STN and the adjacent brain parenchyma. The optimized MR parameters in the PD patients varied according to the individual. For regular SyMRI (T2-weighted imaging [T2WI] and STIR), optimized SyMRI, and QSM, qualitative visualization scores of the STN (STN score) were recorded. The contrast-to-noise ratio (CNR) of the STN was also measured., Results: For the STN scores in both groups, the optimized SyMRI were significantly higher than the regular SyMRI ( P < 0.05), and there were no significant differences between optimized SyMRI and QSM. For the CNR of differentiation of the STN from the substantia nigra, the optimized SyMRI was higher than the regular SyMRI (volunteer: T2WI P = 0.10 and STIR P = 0.26; PD patient: T2WI P = 0.43 and STIR P = 0.25), but the optimized SyMRI was lower than the QSM (volunteer: P = 0.26; PD patient: P = 0.03)., Conclusions: On SyMRI, optimization of MR parameters (TR, TE, and TI) on an individual basis may be useful to increase the conspicuity of the STN.
Published: 2023
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31. Quantification of the Intrinsic T1 and T2 of Heschl's Gyri with MR Fingerprinting.

Author: Maruyama S, Tatsuo S, Tatsuo S, Iida S, Tsushima F, Ide S, and Kakeda S
Subjects: Humans, Adult, Middle Aged, Reproducibility of Results, Magnetic Resonance Imaging methods, Gray Matter diagnostic imaging, Myelin Sheath, Phantoms, Imaging, Auditory Cortex diagnostic imaging, Auditory Cortex pathology
Abstract: Purpose: The human primary auditory cortex is located in the Heschl's gyrus (HG). To assess the intrinsic MR property in the gray matter of the HG (GM-HG) with T1 and T2 values using a commercially available MR fingerprinting (MRF) technique., Methods: The subjects were 10 healthy volunteers (with 20 HGs; mean age, 31.5 years old; range, 25-53 years old). Coronal T1 and T2 maps were obtained with commercially available MRF using a 3-Tesla MR system. Two radiologists measured the T1 and T2 values of the GM-HG, the GM in the superior temporal gyrus (GM-STG), and the GM in the middle temporal gyrus (GM-MTG) by drawing a ROI on coronal maps., Results: For both radiologists, the mean T1 and T2 values of the GM-HG were significantly lower than those in the GM-STG or GM-MTG (P < 0.01). The interobserver reliability using the intraclass correlation coefficients (ICC) (2,1) showed strong agreement for the measurement of the T1 and T2 values (ICCs =⃥ 0.80 and 0.78 for T1 and T2 values, respectively)., Conclusion: The T1 and T2 values on MRF for the GM-HG were lower than those for the GM-STG and GM-MTG, likely reflecting a higher myelin content and iron deposition in the GM-HG. Quantitative measurements using the MRF can clarify cortical properties with high reliability, which may indicate that MRF mapping provides new insights into the structure of the human cortical GM.
Published: 2023
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32. Pollen Food Allergy Syndrome Caused by Japanese Radish: A Case Report.

Author: Uesugi A, Tsushima F, Miyamoto Y, and Harada H
Abstract: Pollen food allergy syndrome (PFAS) is a food allergy that manifests as hypersensitivity symptoms of the oropharyngeal mucosa on ingesting specific foods, and findings resemble herpetic gingivostomatitis. Few reports of PFAS caused by consuming radishes are found in the literature. A 31-year-old man presented to our department with stomatitis and pharyngeal pain. He had no history of allergies. Herpetic gingivostomatitis was suspected. He was admitted to the emergency room a few days later complaining of oral and epigastric pain. Symptoms were similar to those reported previously. He reported frequently consuming raw Japanese radish ( Raphans sativus L.) which gave rise to his symptoms. Japanese radish was suspected as the allergen. The skin-prick test confirmed the diagnosis of PFAS. PFAS can be diagnosed easily once the food-causing symptoms are identified. Upon encountering widespread erosion in the oral cavity, it is essential to consider PFAS as the possible cause., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Dermatology.)
Published: 2023
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33. Correlation of magnetic resonance images with neuropathology of irreversible metronidazole-induced encephalopathy: an autopsy case report.

Author: Miki Y, Takeuchi Y, Murasawa S, Takayasu S, Tsushima F, Kakeda S, Mizukami H, and Wakabayashi K
Subjects: Female, Humans, Metronidazole adverse effects, Dysarthria, Autopsy, Tremor, Magnetic Resonance Imaging, Diffusion Magnetic Resonance Imaging methods, Wernicke Encephalopathy pathology, Brain Diseases chemically induced, Brain Diseases diagnostic imaging, Pancreatic Neoplasms
Abstract: Background: Neurological symptoms and radiographic abnormalities may remain in a small proportion of patients with metronidazole-induced encephalopathy (MIE). Although experimental animal models of MIE have suggested a Wernicke's encephalopathy-like pathology, little is known about the histopathological features of MIE. Here we report the first autopsy case of irreversible MIE., Case Presentation: A 72-year-old Japanese woman with pancreatic neuroendocrine tumour and metastatic tumours in the liver developed intraabdominal bleeding from a hepatic abscess. She was administered metronidazole for 79 days (1.5 g/day), which caused dysarthria followed by hand tremor and altered mental status. Brain magnetic resonance imaging at the time of onset revealed hyperintensities in the deep white matter of the bilateral parietal lobes and splenium of the corpus callosum on diffusion-weighted imaging (DWI) with reduced apparent diffusion coefficient (ADC) values. Despite the improvement of dysarthria and hand tremor, her cognition remained affected even after the withdrawal of metronidazole. She died of pancreatic neuroendocrine tumour at the age of 74 years. Histopathological examinations of the brain confirmed a combination of severe demyelination and moderate axonal degeneration, which corresponded to the regions showing abnormal signal intensities on DWI with reduced ADC values. There were no pathological findings suggestive of Wernicke's encephalopathy in the brain., Conclusion: We have demonstrated the clinical, radiographic and histopathological aspects of irreversible MIE. Hyperintensities on DWI with reduced ADC values in affected regions may indicate a poor clinical prognosis due to irreversible pathological damage., (© 2022. The Author(s).)
Published: 2022
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34. High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma.

Author: Komiyama T, Kuroshima T, Sugasawa T, Fujita SI, Ikami Y, Hirai H, Tsushima F, Michi Y, Kayamori K, Higashino F, and Harada H
Subjects: Humans, Lymphatic Metastasis, Phenotype, Vimentin genetics, Adaptor Proteins, Signal Transducing genetics, DNA-Binding Proteins genetics, Mouth Neoplasms genetics, Mouth Neoplasms pathology, RNA-Binding Proteins genetics, Squamous Cell Carcinoma of Head and Neck pathology
Abstract: The present study aimed to investigate the clinical and biological significance of Src‑associated in mitosis 68 kDa (Sam68) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis was performed on tissue samples obtained from 77 patients with OSCC. Univariate analysis revealed that the high expression of Sam68 was significantly correlated with advanced pathological T stage (P=0.01), positive lymphovascular invasion (P=0.01), and pathological cervical lymph node metastasis (P<0.01). Moreover, multivariate analysis demonstrated that the high expression of Sam68 was an independent predictive factor for cervical lymph node metastasis (odds ratio, 4.39; 95% confidence interval, 1.49‑14.23; P<0.01). These results indicated that high Sam68 expression contributed to tumor progression, especially cervical lymph node metastasis, in OSCC. mRNA sequencing was also performed to assess the changes in the transcriptome between OSCC cells with Sam68 knockdown and control cells with the aim of elucidating the biological roles of Sam68. Gene Ontology enrichment analysis revealed that downregulated differentially expressed genes (DEGs) were concentrated in some biological processes related to epithelial‑mesenchymal transition. Among these DEGs, it was established that vimentin was particularly downregulated in these cells. It was also confirmed that Sam68 knockdown reduced the motility of OSCC cells. Furthermore, the immunohistochemical study of vimentin identified the association between vimentin expression and Sam68 expression as well as cervical lymph node metastasis. In conclusion, the present study suggested that the high expression of Sam68 may contribute to metastasis by regulating vimentin expression and a motile mesenchymal phenotype in OSCC.
Published: 2022
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35. Oral lichenoid contact lesions related to dental metal allergy may resolve after allergen removal.

Author: Tsushima F, Sakurai J, Shimizu R, Kayamori K, and Harada H
Abstract: Background/ Purpose: Distinguishing oral lichenoid contact lesions (OLCLs) from oral lichen planus (OLP) is challenging. This study aimed to identify clinicopathological findings to distinguish OLCLs from OLP, and to evaluate the effectiveness of removing metal allergens in the treatment of OLCLs., Materials and Methods: This study retrospectively evaluated 30 patients diagnosed with OLCLs, and 30 age- and sex-matched OLP patients. We also evaluated the effectiveness of removing dental metal containing positive metal allergen, confirmed by skin patch test and metal component analysis in patients with OLCLs., Results: Palladium and gold were the most common patch test-positive metals observed in the oral cavity of patients with OLCLs. The patients with OLCLs were more likely to present with white type lesions in the buccal mucosa and gingiva than were the patients with OLP (p = 0.030, 0.009, respectively). Overall, 50.0% of patients with OLCLs failed to meet the histopathological diagnostic criteria of OLP. Twenty-three of 24 (95.8%) patients with OLCLs showed a complete or partial improvement after the removal of dental metal., Conclusion: The present findings suggest the importance of a skin patch test and metal component analysis to confirm suspected OLCLs related to dental metal allergy, as these lesions may improve with the removal of the allergy-inducing metal., Competing Interests: The authors have no conflicts of interest relevant to this article., (© 2021 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.)
Published: 2022
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36. Chest radiotherapy after left upper lobectomy may be a risk factor for thrombosis in the pulmonary vein stump.

Author: Song CY, Kimura D, Fukuda I, Tsushima F, Sakai T, and Tsushima T
Subjects: Humans, Pneumonectomy adverse effects, Pneumonectomy methods, Postoperative Complications etiology, Postoperative Complications surgery, Retrospective Studies, Risk Factors, Pulmonary Veins surgery, Thrombosis surgery, Venous Thrombosis etiology, Venous Thrombosis surgery
Abstract: Background: Thrombosis in the pulmonary vein stump (PVS) is not a well-known complication after pulmonary lobectomy, but it has the potential to cause embolism to vital organs. The aim of this study was to evaluate the risk factors for thrombosis in the PVS after pulmonary lobectomy., Methods: A total of 439 patients who underwent pulmonary lobectomy from 2008 to 2017 were retrospectively reviewed, and 412 patients were further analyzed. The state of the PVS was evaluated by chest contrast-enhanced computed tomography (CECT). Univariate analysis was performed to evaluate the potential risk factors for thrombosis in the PVS., Results: Thrombosis in the PVS was detected in 6 of 412 (1.5%) patients, and 5 of them underwent left upper lobectomy (LUL) (5/100, 5.0%) (P = 0.004). In the analyses of the LUL group, postoperative chest radiotherapy was identified as a risk factor for thrombosis in the PVS (P = 0.024), and postoperative atrial fibrillation showed a tendency to be a risk factor for thrombosis (P = 0.058)., Conclusions: Chest radiotherapy after LUL is a possible risk factor for thrombosis in the PVS. Periodic chest CECT is recommended after postoperative chest radiotherapy for patients after LUL., (© 2022. The Author(s).)
Published: 2022
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37. Retrospective analysis of schwannoma in the oral and maxillofacial region: clinicopathological characteristics and specific pathology of ancient change.

Author: Harazono Y, Kayamori K, Sakamoto J, Akaike Y, Kurasawa Y, Tsushima F, Sasaki Y, Harada H, and Yoda T
Subjects: Biopsy, Humans, Retrospective Studies, Neurilemmoma diagnostic imaging, Neurilemmoma pathology, Neurilemmoma surgery
Abstract: Schwannomas are benign tumours that originate from the Schwann cells of the nerve. Despite the frequency of their occurrence in the head and neck, data relating to their clinicopathological features in the region are limited. This study reviews the clinicopathological characteristics and specific pathology of ancient (degenerative) change in 40 cases in the oral and maxillofacial region. Medical records were reviewed of the 40 cases treated at Tokyo Medical and Dental University Hospital Faculty of Dentistry between 2000 and 2020. The most frequently involved site was the tongue, and the average tumour size was 13.2 mm. Degenerative changes were observed in eight cases. All tumours were completely excised through biopsy or local excision, and no recurrence was observed on clinical follow up. Statistical analyses revealed significant associations (p < 0.05) between ancient change and tumour size, and between ancient change and the apparent diffusion coefficient (ADC) value derived from diffusion-weighted magnetic resonance imaging (MRI). Analysis suggests that schwannoma progresses over a long period and subsequently undergoes secondary ancient changes. Pathological events such as cystic formation and haemorrhage that are associated with ancient changes, cause hypocellularity and lead to high ADC values. These values may indicate ancient change and should be considered when distinguishing schwannoma from other lesions., (Copyright © 2021 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
Published: 2022
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38. Effectiveness of Cytological Diagnosis with Outer Cannula Washing Solution for Computed Tomography-Guided Needle Biopsy.

Author: Tatsuo S, Tsushima F, Kakehata S, Fujita H, Maruyama S, Iida S, Tatsuo S, Kumagai N, Matsuzaka M, Kurose A, and Kakeda S
Subjects: Aged, Biopsy, Needle methods, Female, Humans, Male, Retrospective Studies, Sensitivity and Specificity, Tomography, X-Ray Computed methods, Cannula, Image-Guided Biopsy methods
Abstract: Rationale and Objectives: We evaluated the availability of cytological diagnosis with outer cannula washing solution (C-OCWS) as a clinical diagnostic tool for computed tomography (CT)-guided needle biopsy., Materials and Methods: We retrospectively assessed 109 consecutive patients (71 males, 38 females; median age 68 years), who underwent CT-guided needle biopsy. In all patients, the specimens sampled by the inner needle were used for histological diagnosis, and those taken from the outer cannula were rinsed with 0.9% saline solution: outer cannula washing solution for cytological diagnosis. The accuracy of C-OCWS in addition to histological diagnosis were compared with that of histological diagnosis alone. We used binary logistic regression analysis to determine the variables associated with diagnostic accuracy for malignancy and lesion characteristics., Results: The C-OCWS method precisely diagnosed 7 (6.4%) malignant lesions (i.e., effective cases) in the 109 patients characterized as "negative for malignancy" via histological diagnosis alone. The accuracy of the combination of C-OCWS and histological diagnoses was significantly higher than that of histological diagnosis alone (0.95 vs. 0.89, respectively; p = 0.023). Multivariate logistic regression analysis showed that increasing only a marginal ratio (failure rate for proper position of biopsy needle within the tumor) was independently associated with a high rate of effective cases (p = 0.003)., Conclusion: C-OCWS may be helpful for improving the quality of CT-guided needle biopsy, and is a simple method that may not necessarily increase the patients' physical burden., (Copyright © 2021 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
Published: 2022
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39. Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report.

Author: Shimizu R, Tsushima F, Komiya R, Yamagata Y, and Harada H
Abstract: Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2022 by S. Karger AG, Basel.)
Published: 2022
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40. A case report of oral lichenoid lesions related to cross-reactivity between nickel and palladium.

Author: Tsushima F, Sakurai J, Shimizu R, and Harada H
Subjects: Cross Reactions, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact immunology, Female, Humans, Middle Aged, Nickel immunology, Palladium immunology, Patch Tests, Trace Elements immunology, Dental Prosthesis adverse effects, Dermatitis, Allergic Contact etiology, Nickel adverse effects, Palladium adverse effects, Trace Elements adverse effects
Published: 2021
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41. Characteristics of α2,3-sialyl N-glycosylated PSA as a biomarker for clinically significant prostate cancer in men with elevated PSA level.

Author: Yoneyama T, Yamamoto H, Sutoh Yoneyama M, Tobisawa Y, Hatakeyama S, Narita T, Kodama H, Momota M, Ito H, Narita S, Tsushima F, Mitsuzuka K, Yoneyama T, Hashimoto Y, Duivenvoorden W, Pinthus JH, Kakeda S, Ito A, Tsuchiya N, Habuchi T, and Ohyama C
Subjects: Biomarkers, Tumor analysis, Biomarkers, Tumor metabolism, Biopsy methods, Gene Expression Profiling methods, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Multiparametric Magnetic Resonance Imaging methods, Neoplasm Grading, Neoplasm Staging, Neuraminidase metabolism, Prostate diagnostic imaging, Prostate metabolism, Prostate pathology, Prostate-Specific Antigen analysis, Prostate-Specific Antigen metabolism, Prostatic Neoplasms metabolism, Prostatic Neoplasms pathology, Protein Isoforms analysis, Sialyltransferases metabolism
Abstract: Background: The presence of glycosylated isoforms of prostate-specific antigen (PSA) in prostate cancer (PC) cells is a potential marker of their aggressiveness. We characterized the origin of α2,3-sialylated prostate-specific antigen (S23PSA) by tissue-based sialylation-related gene expression and studied the performance of S23PSA density (S23PSAD) alone and in combination with multiparametric magnetic resonance imaging (MRI) for the detection of clinically significant prostate cancer in men with elevated PSA., Methods: Tissue-based quantification of S23PSA and sialyltransferase and sialidase gene expression was evaluated in 71 radical prostatectomy specimens. The diagnostic performance of S23PSAD was studied in 1099 men retrospectively enrolled in a multicenter systematic biopsy (SBx) cohort. We correlated the S23PSAD with Prostate Imaging Reporting and Data System (PI-RADS) scores in 98 men prospectively enrolled in a single-center MRI-targeted biopsy (MRI-TBx) cohort. The primary outcome was the PC-diagnostic performance of the S23PSAD, the secondary outcome was the avoidable biopsy rate of S23PSAD combined with DRE and total PSA (tPSA), and with or without PI-RADS., Results: S23PSA was significantly higher in Gleason pattern 4 and 5 compared with benign prostate tissue. In the retrospective cohort, the performance of S23PSAD for detecting PC was superior to tPSA or PSA density (PSAD) (AUC: 0.7758 vs. 0.6360 and 0.7509, respectively). In the prospective cohort, S23PSAD was superior to tPSA, PSAD, and PI-RADS (AUC: 0.7725 vs. 0.5901, 0.7439 and 0.7305, respectively), and S23PSAD + PI-RADS + DRE + tPSA was superior to DRE + tPSA+PI-RADS with avoidance rate of MRI-TBx (13% vs. 1%) at 30% risk threshold., Conclusions: The diagnostic performance of S23PSAD was superior to conventional strategies but comparable to mpMRI., (© 2021 The Authors. The Prostate published by Wiley Periodicals LLC.)
Published: 2021
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42. Preoperative CT Findings for Predicting Acute Exacerbation of Interstitial Pneumonia After Lung Cancer Surgery: A Multicenter Case-Control Study.

Author: Ozawa Y, Shibamoto Y, Hiroshima M, Nakagawa M, Ono A, Hanaoka R, Yamamoto A, Tominaga J, Kawada H, Koyama M, Takumi K, Tsubakimoto M, Egashira R, Tsushima F, Kikuchi Y, Izumi Y, Ushio T, Kimura M, Ichikawa S, Kitamura N, Matsushita S, Okauchi K, O'uchi T, Ishikawa H, and Kitase M
Subjects: Adult, Aged, Aged, 80 and over, Case-Control Studies, Disease Progression, Female, Humans, Logistic Models, Lung Diseases, Interstitial complications, Lung Diseases, Interstitial pathology, Lung Neoplasms complications, Lung Neoplasms pathology, Male, Middle Aged, Pneumonectomy adverse effects, Postoperative Complications diagnostic imaging, Postoperative Complications pathology, Preoperative Period, Pulmonary Artery diagnostic imaging, Pulmonary Artery pathology, Retrospective Studies, Risk Factors, Lung Diseases, Interstitial diagnostic imaging, Lung Neoplasms surgery, Tomography, X-Ray Computed
Abstract: BACKGROUND. Acute exacerbation (AE) is a life-threatening complication of inter-stitial pneumonia (IP). Thoracic surgery may trigger AE. OBJECTIVE. The purpose of this study is to explore the role of preoperative CT findings in predicting postoperative AE in patients with IP and lung cancer. METHODS. This retrospective case-control study included patients from 22 institutions who had IP and underwent thoracic surgery for lung cancer. AE was diagnosed on the basis of symptoms and imaging findings noted within 30 days after surgery and the absence of alternate causes. For each patient with AE, two control patients without AE were identified. After exclusions, the study included 92 patients (78 men and 14 women; 31 with AE [the AE group] and 61 without AE [the no-AE group]; mean age, 72 years). Two radiologists independently reviewed preoperative thin-slice CT examinations for pulmonary findings and resolved differences by consensus. The AE and no-AE groups were compared using the Fisher exact and Mann-Whitney U tests. Multivariable logistic regression was performed. Interreader agreement was assessed by kappa coefficients. RESULTS. A total of 94% of patients in the AE group underwent segmentectomy or other surgery that was more extensive than wedge resection versus 75% in the no-AE group ( p = .046). The usual IP pattern was present in 58% of the AE group versus 74% of the no-AE group ( p = .16). According to subjective visual scoring, the mean (± SD) ground-glass opacity (GGO) extent was 6.3 ± 5.4 in the AE group versus 3.9 ± 3.8 in the no-AE group ( p = .03), and the mean consolidation extent was 0.5 ± 1.2 in the AE group versus 0.1 ± 0.3 in the no-AE group ( p = .009). Mean pulmonary trunk diameter was 28 ± 4 mm in the AE group versus 26 ± 3 mm in the no-AE group ( p = .02). In a model of CT features only, independent predictors of AE ( p < .05) were GGO extent (odds ratio [OR], 2.8), consolidation extent (OR, 9.4), and pulmonary trunk diameter (OR, 4.2); this model achieved an AUC of 0.75, a PPV of 71%, and an NPV of 77% for AE. When CT and clinical variables were combined, undergoing segmentectomy or more extensive surgery also independently predicted AE (OR, 8.2; p = .02). CONCLUSION. The presence of GGO, consolidation, and pulmonary trunk enlargement on preoperative CT predicts AE in patients with IP who are undergoing lung cancer surgery. CLINICAL IMPACT. Patients with IP and lung cancer should be carefully managed when predictive CT features are present. Wedge resection, if possible, may help reduce the risk of AE in these patients. TRIAL REGISTRATION. University Hospital Medical Information Clinical Trial Registry UMIN000029661.
Published: 2021
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43. Mandibular Reconstruction with Scapular Systems: A Single-Center Case Series Involving 208 Flaps.

Author: Harada H, Shimamoto H, Oikawa Y, Kuroshima T, Tomioka H, Hirai H, Tsushima F, and Michi Y
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Free Tissue Flaps adverse effects, Humans, Male, Mandible pathology, Mandible surgery, Mandibular Neoplasms pathology, Mandibular Reconstruction adverse effects, Middle Aged, Necrosis epidemiology, Necrosis etiology, Necrosis pathology, Osteotomy adverse effects, Postoperative Complications etiology, Postoperative Complications pathology, Retrospective Studies, Treatment Outcome, Young Adult, Free Tissue Flaps transplantation, Mandibular Neoplasms surgery, Mandibular Reconstruction methods, Postoperative Complications epidemiology, Scapula transplantation
Abstract: Background: The scapular flap is the most versatile composite flap used for mandibular reconstruction. The purpose of this study was to review and summarize findings of cases of mandibular reconstruction with a scapular flap and describe associated outcomes and complications., Methods: A total of 208 microvascular scapular free flaps were performed for mandibular reconstruction in a total of 205 patients from 2003 to 2018. This study involved a retrospective review of all eligible patients' medical records., Results: There were seven cases (3.4 percent) of microvascular thrombosis. Postoperative bone union was achieved by 201 patients, except for five with total flap necrosis and two with partial flap necrosis. There were four cases (1.9 percent) of mandibular condyle dislocation. Two major types of complications were observed at the donor site, including four cases of infection and six cases of scapular body fracture. Postoperative denture prosthesis was introduced to 97 patients (47.3 percent). Implant treatment was performed in 10 patients (4.9 percent). Functional and aesthetic outcomes were good to excellent., Conclusions: The scapular composite free flap for mandibular reconstruction was associated with favorable outcomes and demonstrated satisfactory results. Although scapular bone fracture is rare, patients who have undergone mandibular reconstruction using a scapular flap should be monitored for its presence. ., Clinical Question/level of Evidence: Therapeutic, IV., (Copyright © 2021 by the American Society of Plastic Surgeons.)
Published: 2021
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44. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients.

Author: Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, Hirai H, Kayamori K, and Harada H
Subjects: Cell Transformation, Neoplastic, Female, Humans, Japan epidemiology, Male, Retrospective Studies, Lichen Planus, Oral, Mouth Neoplasms
Abstract: Background: Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear., Methods: We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded., Results: The study population included 123 men and 442 women aged 21-93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type., Conclusions: Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.
Published: 2021
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45. Leptomeningeal and intraventricular myelomatosis manifesting an aggressive form of communicating hydrocephalus.

Author: Miki Y, Kamata K, Akemoto Y, Tsushima F, Sakuraba H, Yamagata K, Kurose A, Fukuda S, and Wakabayashi K
Subjects: Autopsy, Bence Jones Protein urine, Humans, Male, Meningeal Neoplasms, Meninges pathology, Middle Aged, Neuroimaging, Hydrocephalus diagnosis, Hydrocephalus etiology, Hydrocephalus pathology, Multiple Myeloma complications, Multiple Myeloma pathology
Abstract: Leptomeningeal myelomatosis (LMM) is a fatal complication that occurs in < 1% of patients with multiple myeloma. Many patients with LMM present with neurologic symptoms referable to cranial neuropathies, while the manifestation of communicating hydrocephalus has been underrecognized. A Japanese man with Bence Jones protein-κ multiple myeloma developed fever and headache at age 54 years. He then became somnolent and went into a coma. Neuroimaging analyses identified rapidly progressive communicating hydrocephalus due to meningitis. He died 83 days after the onset of headache without any response to treatment at age 55 years. No symptoms or signs associated with cranial nerves were found during the course of illness. Postmortem examination revealed hydrocephalus and diffuse infiltration of myeloma cells into the subarachnoid space of the cerebrum, cerebellum, and brainstem. In addition, the interstitial tissue of the choroid plexuses was filled with myeloma cells. These myeloma cells were positive for CD156 and light chain κ. The Ki-67 labeling index in myeloma cells of the central nervous system (CNS) was 30-40%. Histopathological examination further revealed many myeloma cells on the surface of the lateral, third and fourth ventricles and at the area postrema of the medulla oblongata. Patients with LMM can develop an aggressive form of communicating hydrocephalus. Given that cerebrospinal fluid, produced by epithelial cells in the choroid plexuses of the ventricles, passes into the subarachnoid space through the third and fourth ventricles, myeloma cells may invade the CNS through the choroid plexuses., (© 2021 Japanese Society of Neuropathology.)
Published: 2021
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46. High-signal venous sinuses on MR angiography: discrimination between reversal of venous flow and arteriovenous shunting using arterial spin labeling.

Author: Iwamura M, Midorikawa H, Shibutani K, Kakuta A, Maruyama S, Yotsuya C, Tatsuo S, Fujita H, Kakehata S, Tsushima F, Nozaki A, Sugimoto K, and Kakeda S
Subjects: Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Spin Labels, Cavernous Sinus, Central Nervous System Vascular Malformations diagnostic imaging
Abstract: Purpose: It is sometimes difficult to differentiate between high signals originating from a reverse flow on magnetic resonance angiography (MRA) and occult arteriovenous shunting. We attempted to determine whether arterial spin labeling (ASL) can be used to discriminate reversal of venous flow from arteriovenous shunting for high-signal venous sinuses on MR angiography., Methods: Two radiologists evaluated the signals of the venous sinus on MRA and ASL obtained from 364 cases without arteriovenous shunting. In addition, the findings on MRA were compared with those on ASL in an additional 13 patients who had dural arteriovenous fistula (DAVF)., Results: In the 364 cases (728 sides) without arteriovenous shunting, a high signal due to reverse flow in the cavernous sinuses (CS) was observed on 99 sides (13.6%) on MRA and none on ASL. Of these cases, a high signal in the sigmoid sinus, transverse sinus, and internal jugular vein was seen on 3, 3, and 8 sides, respectively. All of these venous sinuses showed a high signal from the reverse flow on MRA images., Conclusion: ASL is a simple and useful MR imaging sequence for differentiating between reversal of venous flow and CS DAVF. In the sigmoid and transverse sinus, ASL showed false-positives due to the reverse flow from the jugular vein, which may be a limitation of which radiologists should be aware.
Published: 2021
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47. Oral granuloma in a pediatric patient with chronic graft-versus-host disease: A case report.

Author: Uesugi A, Tsushima F, Kodama M, Kuroshima T, Sakurai J, and Harada H
Abstract: Background: Oral mucositis is often observed with graft-versus-host disease (GVHD); however, the occurrence of oral granuloma is rare. The rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those patients. This case is the youngest pediatric patient with granuloma associated with GVHD., Case Summary: The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral nodules. At the age of 5 mo, she was diagnosed with primary immunodeficiency disease, cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of age. After transplantation, GVHD and oral mucositis developed, and tacrolimus was administered. Interestingly, nodules appeared on the lower lip and buccal mucosa, which spontaneously disappeared. Then, a new nodule appeared on the left lateral border of the tongue. Resection was performed and the histopathological diagnosis was granuloma. The origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their proliferation., Conclusion: It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered., Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest., (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.)
Published: 2020
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48. Detection of extraoral primary cancers by positron emission tomography/computed tomography in patients with oral squamous cell carcinoma.

Author: Ohsako T, Shimamoto H, Tomioka H, Hirai H, Kuroshima T, Mochizuki Y, Kugimoto T, Tsushima F, Nakamura S, Kurabayashi T, and Harada H
Subjects: Fluorodeoxyglucose F18, Humans, Male, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Radiopharmaceuticals, Retrospective Studies, Survival Rate, Carcinoma, Squamous Cell, Mouth Neoplasms
Abstract: Objective: Extraoral primary cancers (EPCs) can appear in patients with oral cancer. This study investigated the use of positron emission tomography/computed tomography (PET/CT) to detect EPCs and to identify characteristics of these cancers. The disease-specific survival rate and the overall survival rate were calculated., Study Design: We studied records for 891 patients with oral cancer who underwent PET/CT between January 2006 and December 2016 for the detection of EPCs., Results: A total of 35 EPCs were detected by PET/CT in 34 patients with primary oral carcinoma (3.8%). Of this total, 33 patients had 1 EPC and 1 patient had 2 EPCs. The extraoral lesions were found in the upper gastrointestinal tract (11), colon (6), lung (5), kidney (3), liver (2), prostate (2), breast (2), bladder (1), thyroid (1), pancreas (1), and hypopharynx (1). The disease-specific survival rate was 84.8% and the overall survival rate was 64.6%., Conclusions: PET/CT was useful for early detection of EPCs. The use of PET/CT for the early detection and treatment of EPCs with no symptoms can improve treatment outcomes., (Copyright © 2019 Elsevier Inc. All rights reserved.)
Published: 2020
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49. Management of retropharyngeal lymph node metastasis in oral cancer.

Author: Oikawa Y, Michi Y, Tsushima F, Tomioka H, Mochizuki Y, Kugimoto T, Osako T, Nojima H, Yokokawa M, Kashima Y, and Harada H
Subjects: Adult, Aged, Female, Humans, Lymph Nodes pathology, Male, Middle Aged, Mouth Neoplasms pathology, Prognosis, Lymphatic Metastasis pathology, Mouth Neoplasms complications
Abstract: Objectives: Retropharyngeal lymph node (RPLN) metastasis is extremely rare, and prognosis is significantly poor in oral cancer. We retrospectively examined the management of RPLN metastases in oral cancer., Materials and Methods: A total of 1247 patients with oral cancer were treated at our department from January 2002 and December 2016. Among these patients, 374 (30%) had histologically positive lymph node metastases. Of these, 15 patients (1.2%) were diagnosed with RPLN metastases. We evaluated the diagnostic period, size, recurrence pattern, laterality, treatment, and therapeutic outcomes. The Kaplan-Meier method was used to determine overall survival (OS) among the RPLN metastasis group, cervical lymph node (CLN) metastases group, and treatment methods group for RPLN metastases., Results: One patient had RPLN involvement at the initial treatment, and RPLN involvement in other patients was found subsequently. The mean duration in confirming RPLN metastases was 228 days (range, 50-867 days). Surgical therapy was performed in 5 patients, chemoradiotherapy in 7 patients, and best supported care (BSC) in 3 patients. The cumulative 5-year OS rate for the RPLN metastasis group (n = 15) was 38.1%, compared with the rate of 71.3% for the CLN group (n = 359). Regarding the therapeutic approach for RPLN metastases, OS rates were 80.0% (n = 5) in the surgical therapy group, 28.6% (n = 7) in the chemoradiotherapy group, and 0% (n = 3) in the BSC group., Conclusion: Early detection and surgical treatment of RPLN metastases are associated with increased survival rate in oral cancer., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
Published: 2019
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50. Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw (MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis.

Author: Komiya R, Wada T, Tsushima F, Sakamoto K, Ikeda T, Yamaguchi A, Harada H, and Uo M
Subjects: Adult, Aged, Aged, 80 and over, Bisphosphonate-Associated Osteonecrosis of the Jaw pathology, Female, Fluorescence, Humans, Male, Middle Aged, X-Rays, Bisphosphonate-Associated Osteonecrosis of the Jaw metabolism, Spectrophotometry, Atomic methods, Synchrotrons, Trace Elements analysis
Abstract: Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive agents like bisphosphonates. Abnormal concentrations of various trace metallic elements contained in bone minerals have been associated with MRONJ. In this study, we focused on trace metallic elements contained in the MRONJ sequestrum; their content and distribution were compared to those in osteomyelitis and non-inflammatory bones using inductively coupled plasma atomic emission spectroscopy (ICP-AES) and synchrotron radiation X-ray fluorescence analysis (SR-XRF). On ICP-AES analyses, various trace elements (Co, Cr, Cu, Fe, K, Mg, Ni, Sb, Ti, V, Pb) were significantly more in MRONJ sequestra than non-inflammatory bones. The Cu content was significantly higher in MRONJ sequestra than osteomyelitis and non-inflammatory bones. The Cu content in MRONJ sequestra was high even after decalcification. Additionally, Cu was distributed along the trabecular structures in decalcified MRONJ specimens, as observed using SR-XRF analysis. Therefore, this study was indicative of the characteristic behavior of Cu in MRONJ.
Published: 2019
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