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Your search keyword '"Tsuno, Takahiro"' showing total 18 results
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18 results on '"Tsuno, Takahiro"'

3. Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER

Author

Inoue, Ryota, Tsuno, Takahiro, Togashi, Yu, Okuyama, Tomoko, Sato, Aoi, Nishiyama, Kuniyuki, Kyohara, Mayu, Li, Jinghe, Fukushima, Setsuko, Kin, Tatsuya, Miyashita, Daisuke, Shiba, Yusuke, Atobe, Yoshitoshi, Kiyonari, Hiroshi, Bando, Kana, Shapiro, A.M. James, Funakoshi, Kengo, Kulkarni, Rohit N., Terauchi, Yasuo, and Shirakawa, Jun

Published
2022
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5. Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice

Author

Nishiyama, Kuniyuki, primary, Ono, Masato, additional, Tsuno, Takahiro, additional, Inoue, Ryota, additional, Fukunaka, Ayako, additional, Okuyama, Tomoko, additional, Kyohara, Mayu, additional, Togashi, Yu, additional, Fukushima, Setsuko, additional, Atsumi, Takuto, additional, Sato, Aoi, additional, Tsurumoto, Asuka, additional, Sakai, Chisato, additional, Fujitani, Yoshio, additional, Terauchi, Yasuo, additional, Ito, Shuichi, additional, and Shirakawa, Jun, additional

Published
2023
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9. E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

Author

Shirakawa, Jun, primary, Togashi, Yu, additional, Basile, Giorgio, additional, Okuyama, Tomoko, additional, Inoue, Ryota, additional, Fernandez, Megan, additional, Kyohara, Mayu, additional, De Jesus, Dario F., additional, Goto, Nozomi, additional, Zhang, Wei, additional, Tsuno, Takahiro, additional, Kin, Tatsuya, additional, Pan, Hui, additional, Dreyfuss, Jonathan M., additional, Shapiro, A.M. James, additional, Yi, Peng, additional, Terauchi, Yasuo, additional, and Kulkarni, Rohit N., additional

Published
2022
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10. Abdominal aortic calcification is associated with Fibrosis‐4 index and low body mass index in type 2 diabetes patients: A retrospective cross‐sectional study

Author

Togashi, Yu, primary, Miyashita, Daisuke, additional, Tsuno, Takahiro, additional, Inoue, Ryota, additional, Okuyama, Tomoko, additional, Kyohara, Mayu, additional, Nishiyama, Kuniyuki, additional, Arai, Masanori, additional, Kanematsu, Kenta, additional, Kanataki, Soichiro, additional, Terauchi, Yasuo, additional, and Shirakawa, Jun, additional

Published
2022
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11. Protective Effects of the Alarmin S100A8 From Monocytes/Macrophages on Sepsis Mortality: Links to Sepsis Risk in Obesity and Diabetes

Author

Miyashita, Daisuke, primary, Inoue, Ryota, additional, Tsuno, Takahiro, additional, Okuyama, Tomoko, additional, Kyohara, Mayu, additional, Nakahashi-Oda, Chigusa, additional, Nishiyama, Kuniyuki, additional, Inada, Yutaro, additional, Togashi, Yu, additional, Shibuya, Akira, additional, Terauchi, Yasuhiro, additional, and Shirakawa, Jun, additional

Published
2022
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12. Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway

Author

Li, Jinghe, primary, Inoue, Ryota, additional, Togashi, Yu, additional, Okuyama, Tomoko, additional, Satoh, Aoi, additional, Kyohara, Mayu, additional, Nishiyama, Kuniyuki, additional, Tsuno, Takahiro, additional, Miyashita, Daisuke, additional, Kin, Tatsuya, additional, Shapiro, A.M. James, additional, Chew, Resilind Su Ern, additional, Teo, Adrian Kee Keong, additional, Oyadomari, Seiichi, additional, Terauchi, Yasuo, additional, and Shirakawa, Jun, additional

Published
2021
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14. Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway.

Author

Li, Jinghe, Inoue, Ryota, Togashi, Yu, Okuyama, Tomoko, Satoh, Aoi, Kyohara, Mayu, Nishiyama, Kuniyuki, Tsuno, Takahiro, Miyashita, Daisuke, Kin, Tatsuya, Shapiro, A.M. James, Chew, Resilind Su Ern, Teo, Adrian Kee Keong, Oyadomari, Seiichi, Terauchi, Yasuo, and Shirakawa, Jun

Subjects
ENDOPLASMIC reticulum, HOMEOSTASIS, APOPTOSIS, PROTEIN synthesis, SECRETION, MITOCHONDRIAL physiology, PROTEINS, RESEARCH, HETEROCYCLIC compounds, ANIMAL experimentation, HYPOGLYCEMIC agents, CELL physiology, EVALUATION research, ISLANDS of Langerhans, MITOCHONDRIA, COMPARATIVE studies, STEM cells, CELL lines, ESTERASES, GLUCOSE, CYTOPLASM, MICE
Abstract

The effects of imeglimin, a novel antidiabetes agent, on β-cell function remain unclear. Here, we unveiled the impact of imeglimin on β-cell survival. Treatment with imeglimin augmented mitochondrial function, enhanced insulin secretion, promoted β-cell proliferation, and improved β-cell survival in mouse islets. Imeglimin upregulated the expression of endoplasmic reticulum (ER)-related molecules, including Chop (Ddit3), Gadd34 (Ppp1r15a), Atf3, and Sdf2l1, and decreased eIF2α phosphorylation after treatment with thapsigargin and restored global protein synthesis in β-cells under ER stress. Imeglimin failed to protect against ER stress-induced β-cell apoptosis in CHOP-deficient islets or in the presence of GADD34 inhibitor. Treatment with imeglimin showed a significant decrease in the number of apoptotic β-cells and increased β-cell mass in Akita mice. Imeglimin also protected against β-cell apoptosis in both human islets and human pluripotent stem cell-derived β-like cells. Taken together, imeglimin modulates the ER homeostasis pathway, which results in the prevention of β-cell apoptosis both in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Hydrogen Leader City Project

Author

MIYAJIMA, Hideki, primary, MATSUMOTO, Ryo, additional, TAJIMA, Masaki, additional, TSUNO, Takahiro, additional, and SASAKI, Yuko, additional

Published
2016
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18. Encapsulated human islets in alginate fiber maintain long-term functionality.

Author

Nishida J, Tsuno T, G Yabe S, Kin T, Fukuda S, Takeda F, Shirakawa J, and Okochi H

Subjects
Humans, Glucagon pharmacology, C-Peptide, Alginates pharmacology, Glucose pharmacology, Insulin pharmacology, Islets of Langerhans, Islets of Langerhans Transplantation
Abstract

Maintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distribution Program. Encapsulated human islets from 15 deceased donors were cultured under 5.5 or 25 mM glucose conditions in vitro. The amounts of C-peptide and glucagon secreted from encapsulated islets into the culture media were measured periodically, and immunohistochemical studies were performed. Encapsulated islets maintained C-peptide and glucagon secretion for more than 75 days in 5 cases; in two cases, their secretion was also successfully detected even on day 180. α- and β-cell composition and β-cell survival in islets were unaltered in the fiber after 75 or 180 days of culture. The encapsulated islets cultured with 5.5 mM glucose, but not those with 25 mM glucose, exhibited glucose responsiveness of C-peptide secretion until day 180. We demonstrate that alginate encapsulation enabled human islets to maintain their viability and glucose responsiveness of C-peptide secretion after long-term in vitro culture, potentially for more than for 180 days.

Published
2024
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