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2 results on '"Tsungai Mhembere"'

1. Efficacy and safety of three antiretroviral therapy regimens started in pregnancy up to 50 weeks post partum: a multicentre, open-label, randomised, controlled, phase 3 trial

Author

Lameck Chinula, Lauren Ziemba, Sean Brummel, Katie McCarthy, Anne Coletti, Chelsea Krotje, Benjamin Johnston, Kevin Knowles, Sikhulile Moyo, Lynda Stranix-Chibanda, Risa Hoffman, Paul E Sax, Jeffrey Stringer, Nahida Chakhtoura, Patrick Jean-Philippe, Violet Korutaro, Haseena Cassim, Lee Fairlie, Gaerolwe Masheto, Ceejay Boyce, Lisa M Frenkel, K Rivet Amico, Lynette Purdue, Roger Shapiro, Blandina Theophil Mmbaga, Faeezah Patel, Jean van Wyk, James F Rooney, Judith S Currier, Shahin Lockman, Brookie M. Best, Cheryl D Blanchette, Renee Browning, Nagawa Jaliaah, Mark Mirochnick, William A. Murtaugh, Emmanuel Patras, Frances Whalen, Jeremiah D. Momper, Ponego L. Ponatshego, Lesedi Tirelo, Boitshepo J. Seme, Georginah O. Modise, Mpho S. Raesi, Marian E. Budu, Moakanyi Ramogodiri, Ricardo H. Oliveira, Cristina B Hofe, Thalita Fernandes de Abreu, Lorena M. Pestanha, Esaú João, Leon C. Sidi, Trevon Fuller, Maria L.S Cruz, Jorge Pinto, Flãvia Ferreira, Mãrio Correa Jr, Juliana Romeiro, Jose H. Pilotto, Luis E.B.C Fernandes, Luiz F. Moreira, Ivete M. Gomes, Shilpa Naik, Neetal Nevrekar, Vidya Mave, Aarti Kinikar, Elizea Horne, Hamisha Soma-Kasiram, Avy Violari, Sisinyana R. Mathiba, Mandisa Nyati, Gerhard Theron, Jeanne de Jager, Magdel Rossouw, Lindie Rossouw, Sherika Hanley, Alicia C. Desmond, Rosemary Gazu, Vani Govender, Amphan Chalermchockcharoenkit, Manopchai Thamkhantho, Peerawong Werarak, Supattra Rungmaitree, Jullapong Achalapong, Lukkana Sitiritkawin, Tim R. Cressey, Pra-ornsuda Sukrakanchana, Linda Aurpibul, Fuanglada Tongprasert, Chintana Khamrong, Sopida Kiattivej, Deo Wabwire, Enid Kabugo, Joel Maena, Frances Nakayiwa, Victoria Ndyanabangi, Beatrice Nagaddya, Rogers Sekabira, Justus Ashaba, Charles D. Mitchell, Adriana Drada, Grace A. Alvarez, Gwendolyn B. Scott, Mobeen Rathore, Saniyyah Mahmoudi, Adnan Shabbir, Nizar Maraqa, Patricia F. Mandima, Mercy Mutambanengwe, Suzen Maonera, Gift Chareka, Teacler Nematadzira, Vongai Chanaiwa, Taguma A. Matubu, Kevin Tamirepi, Sukunena Maturure, Tsungai Mhembere, Tichaona Vhembo, and Tinashe Chidemo

Subjects
Infectious Diseases, Epidemiology, Virology, Immunology
Published
2023
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2. Pharmacokinetics and Drug-Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping

Author

Adriana Weinberg, Tsungai Mhembere, Grace Montepiedra, Ramesh Bhosale, Kamunkhwala Gausi, Tichaona Vhembo, Lubbe Wiesner, Lisa Aaron, Amita Gupta, Timothy R. Sterling, David W. Haas, Carole L. Wallis, Jennifer Norman, Nahida Chakhtoura, Avy Violari, Katie McCarthy, Enid Kabugho, Lynda Stranix-Chibanda, Vanessa Rouzier, Mercy Mutambanengwe, Katherine Shin, Bonnie Zimmer, Sarah Bradford, Fuanglada Tongprasert, Diane Costello, Renee Browning, Gerhard Theron, Tsungai Chipato, Linda Aurpibul, Blandina T. Mmbaga, Patrick Jean-Philippe, Vongai Chanaiwa, Neetal Nevrekhar, Anneke C. Hesseling, Paolo Denti, Mandisa Nyati, Gaerolwe Masheto, and Carolyne Onyango-Makumbi

Subjects
Cyclopropanes, CYP2B6, Arylamine N-Acetyltransferase, Antitubercular Agents, HIV Infections, 030226 pharmacology & pharmacy, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Pharmacology (medical), Drug Interactions, Prospective Studies, media_common, Incidence (epidemiology), Isoniazid, virus diseases, Articles, Middle Aged, 030220 oncology & carcinogenesis, Alkynes, Reverse Transcriptase Inhibitors, Female, medicine.drug, Drug, Adult, medicine.medical_specialty, Efavirenz, Adolescent, Genotype, Anti-HIV Agents, Metabolic Clearance Rate, media_common.quotation_subject, Equivalence Trials as Topic, Article, 03 medical and health sciences, Young Adult, Pharmacokinetics, Double-Blind Method, Internal medicine, medicine, Humans, Tuberculosis, Pharmacology, business.industry, Research, Body Weight, medicine.disease, Benzoxazines, Cytochrome P-450 CYP2B6, chemistry, Pharmacogenomics, business
Abstract

The World Health Organization guidelines recommend that individuals living with HIV receive ≥ 6 months of isoniazid preventive therapy, including pregnant women. Yet, plasma isoniazid exposure during pregnancy, in the antiretroviral therapy era, has not been well-described. We investigated pregnancy-induced and pharmacogenetic-associated pharmacokinetic changes and drug-drug interactions between isoniazid and efavirenz in pregnant women. Eight hundred forty-seven women received isoniazid for 28 weeks, either during pregnancy or at 12 weeks postpartum, and 786 women received efavirenz. After adjusting for NAT2 and CYP2B6 genotype and weight, pregnancy increased isoniazid and efavirenz clearance by 26% and 15%, respectively. Isoniazid decreased efavirenz clearance by 7% in CYP2B6 normal metabolizers and 13% in slow and intermediate metabolizers. Overall, both isoniazid and efavirenz exposures were reduced during pregnancy, but the main determinants of drug concentration were NAT2 and CYP2B6 genotypes, which resulted in a five-fold difference for both drugs between rapid and slow metabolizers.

Published
2020

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