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2. How Successful Is Parenteral Oxycodone for Relieving Terminal Cancer Dyspnea Compared With Morphine? A Multicenter Prospective Observational Study

Author

Inoue, Satoshi, Yokomichi, Naosuke, Imai, Kengo, Morita, Tatsuya, Mori, Masanori, Tsukuura, Hiroaki, Yamauchi, Toshihiro, Naito, Akemi Shirado, Uneno, Yu, Yoshioka, Akira, Hiramoto, Shuji, Kikuchi, Ayako, Hori, Tetsuo, Matsuda, Yosuke, Kohara, Hiroyuki, Fanaki, Hiromi, Tanaka, Keiko, Suzuki, Kozue, Kamei, Tina, Azuma, Yukari, Amano, Koji, Uno, Teruaki, Miyamoto, Jiro, Katayama, Hirofumi, Kashiwagi, Hideyuki, Matsumoto, Eri, Oya, Kiyofumi, Yamaguchi, Takeya, Okamura, Tomonao, Hashimoto, Hoshu, Kosugi, Shunsuke, Ikuta, Nao, Matsumoto, Yaichiro, Ohmori, Takashi, Nakai, Takehiro, Ikee, Takashi, Unoki, Yuto, Kitade, Kazuki, Koito, Shu, Ishibashi, Nanao, Ehara, Masaya, Kuwahara, Kosuke, Ueno, Shohei, Nakashima, Shunsuke, Ishiyama, Yuta, Sakashita, Akihiro, Matsunuma, Ryo, Takatsu, Hana, Yamaguchi, Takashi, Ito, Satoko, Terabayashi, Toru, Nakagawa, Jun, Yamagiwa, Tetsuya, Inoue, Akira, Yamaguchi, Takuhiro, Miyashita, Mitsunori, Yoshida, Saran, Hiratsuka, Yusuke, Tagami, Keita, Watanabe, Hiroaki, Odagiri, Takuya, Ito, Tetsuya, Ikenaga, Masayuki, Shimizu, Keiji, Hayakawa, Akira, Kamura, Rena, Okoshi, Takeru, Maeda, Isseki, Nishi, Tomohiro, Kosugi, Kazuhiro, Shibata, Yasuhiro, Hisanaga, Takayuki, Higashibata, Takahiro, Yabuki, Ritsuko, Hagiwara, Shingo, Shimokawa, Miho, Miyake, Satoshi, Nozato, Junko, Ishiki, Hiroto, Iriyama, Tetsuji, Kaneishi, Keisuke, Baba, Mika, Miura, Tomofumi, Matsumoto, Yoshihisa, Okizaki, Ayumi, Watanabe, Yuki Sumazaki, uehara, Yuko, Satomi, Eriko, Nishijima, Kaoru, Shimoinaba, Junichi, Nakahori, Ryoichi, Hirohashi, Takeshi, Hamano, Jun, Kawashima, Natsuki, Kawaguchi, Takashi, Uchida, Megumi, Sato, Ko, Matsuda, Yoichi, Hatano, Yutaka, Tsuneto, Satoru, Maeda, Sayaka, Kizawa, Yoshiyuki, Otani, Hiroyuki, and Uehara, Yuko

Published
2021
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3. Additive Duloxetine for Cancer-Related Neuropathic Pain Nonresponsive or Intolerant to Opioid-Pregabalin Therapy: A Randomized Controlled Trial (JORTC-PAL08)

Author

Matsuoka, Hiromichi, Iwase, Satoru, Miyaji, Tempei, Kawaguchi, Takashi, Ariyoshi, Keisuke, Oyamada, Shunsuke, Satomi, Eriko, Ishiki, Hiroto, Hasuo, Hideaki, Sakuma, Hiroko, Tokoro, Akihiro, Shinomiya, Toshiaki, Otani, Hiroyuki, Ohtake, Yoichi, Tsukuura, Hiroaki, Matsumoto, Yoshihisa, Hasegawa, Yoshikazu, Kataoka, Yuki, Otsuka, Masatomo, Sakai, Kiyohiro, Matsuda, Yoshinobu, Morita, Tatsuya, Koyama, Atsuko, and Yamaguchi, Takuhiro

Published
2019
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4. Predictors of duloxetine response in patients with neuropathic cancer pain: a secondary analysis of a randomized controlled trial—JORTC-PAL08 (DIRECT) study

Author

Matsuoka, Hiromichi, Iwase, Satoru, Miyaji, Tempei, Kawaguchi, Takashi, Ariyoshi, Keisuke, Oyamada, Shunsuke, Satomi, Eriko, Ishiki, Hiroto, Hasuo, Hideaki, Sakuma, Hiroko, Tokoro, Akihiro, Matsuda, Yoshinobu, Tahara, Kazuki, Otani, Hiroyuki, Ohtake, Yoichi, Tsukuura, Hiroaki, Matsumoto, Yoshihisa, Hasegawa, Yoshikazu, Kataoka, Yuki, Otsuka, Masatomo, Sakai, Kiyohiro, Nakura, Miki, Morita, Tatsuya, Yamaguchi, Takuhiro, and Koyama, Atsuko

Published
2020
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8. The Effect of High-flow Nasal Cannula Oxygen for Dyspnea in Patients with Advanced Disease: Systematic Review

Author

Goya, Sho, primary, Nakano, Yasushi, additional, Tsukuura, Hiroaki, additional, Takagi, Yusuke, additional, Watanabe, Hiroaki, additional, Matsuda, Yoshinobu, additional, Kako, Jun, additional, Kasahara, Yoko, additional, Kohara, Hiroyuki, additional, Mori, Masanori, additional, Nakayama, Takeo, additional, and Yamaguchi, Takashi, additional

Published
2023
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9. Symptoms, performance status and phase of illness in advanced cancer: multicentre cross-sectional study of palliative care unit admissions

Author

Ohinata, Hironori, primary, Aoyama, Maho, additional, Hiratsuka, Yusuke, additional, Mori, Masanori, additional, Kikuchi, Ayako, additional, Tsukuura, Hiroaki, additional, Matsuda, Yosuke, additional, Suzuki, Kozue, additional, Kohara, Hiroyuki, additional, Maeda, Isseki, additional, Morita, Tatsuya, additional, and Miyashita, Mitsunori, additional

Published
2022
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10. Association of the RASS Score with Intensity of Symptoms, Discomfort, and Communication Capacity in Terminally Ill Cancer Patients Receiving Palliative Sedation: Is RASS an Appropriate Outcome Measure?

Author

Imai, Kengo, primary, Morita, Tatsuya, additional, Yokomichi, Naosuke, additional, Mori, Masanori, additional, Naito, Akemi Shirado, additional, Yamauchi, Toshihiro, additional, Tsukuura, Hiroaki, additional, Uneno, Yu, additional, Tsuneto, Satoru, additional, and Inoue, Satoshi, additional

Published
2022
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11. Association between experiences of advanced cancer patients at the end of life and depression in their bereaved caregivers

Author

Hatano, Yutaka, primary, Morita, Tatsuya, additional, Mori, Masanori, additional, Aoyama, Maho, additional, Yoshida, Saran, additional, Amano, Koji, additional, Terabayashi, Toru, additional, Oya, Kiyofumi, additional, Tsukuura, Hiroaki, additional, Hiratsuka, Yusuke, additional, Maeda, Isseki, additional, Kizawa, Yoshiyuki, additional, Tsuneto, Satoru, additional, Shima, Yasuo, additional, Masukawa, Kento, additional, and Miyashita, Mitsunori, additional

Published
2022
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12. The prevalence of artificially administered nutrition and hydration in different age groups among patients with advanced cancer admitted to palliative care units

Author

Amano, Koji, primary, Satomi, Eriko, additional, Oyamada, Shunsuke, additional, Ishiki, Hiroto, additional, Sakashita, Akihiro, additional, Miura, Tomofumi, additional, Maeda, Isseki, additional, Hatano, Yutaka, additional, Yamauchi, Toshihiro, additional, Oya, Kiyofumi, additional, Nakagawa, Jun, additional, Hiratsuka, Yusuke, additional, Hirohashi, Takeshi, additional, Morita, Tatsuya, additional, Mori, Masanori, additional, Inoue, Satoshi, additional, Yokomichi, Naosuke, additional, Imai, Kengo, additional, Tsukuura, Hiroaki, additional, Naito, Akemi Shirado, additional, Uneno, Yu, additional, Yoshioka, Akira, additional, Hiramoto, Shuji, additional, Kikuchi, Ayako, additional, Hori, Tetsuo, additional, Matsuda, Yosuke, additional, Kohara, Hiroyuki, additional, Funaki, Hiromi, additional, Tanaka, Keiko, additional, Suzuki, Kozue, additional, Kamei, Tina, additional, Azuma, Yukari, additional, Uno, Teruaki, additional, Miyamoto, Jiro, additional, Katayama, Hirofumi, additional, Kashiwagi, Hideyuki, additional, Matsumoto, Eri, additional, Yamaguchi, Takeya, additional, Okamura, Tomonao, additional, Hashimoto, Hoshu, additional, Kosugi, Shunsuke, additional, Ikuta, Nao, additional, Matsumoto, Yaichiro, additional, Ohmori, Takashi, additional, Nakai, Takehiro, additional, Ikee, Takashi, additional, Unoki, Yuto, additional, Kitade, Kazuki, additional, Koito, Shu, additional, Ishibashi, Nanao, additional, Ehara, Masaya, additional, Kuwahara, Kosuke, additional, Ueno, Shohei, additional, Nakashima, Shunsuke, additional, Ishiyama, Yuta, additional, Matsunuma, Ryo, additional, Takatsu, Hana, additional, Yamaguchi, Takashi, additional, Ito, Satoko, additional, Terabayashi, Toru, additional, Yamagiwa, Tetsuya, additional, Inoue, Akira, additional, Yamaguchi, Takuhiro, additional, Miyashita, Mitsunori, additional, Yoshida, Saran, additional, Tagami, Keita, additional, Watanabe, Hiroaki, additional, Odagiri, Takuya, additional, Ito, Tetsuya, additional, Ikenaga, Masayuki, additional, Shimizu, Keiji, additional, Hayakawa, Akira, additional, Kamura, Rena, additional, Okoshi, Takeru, additional, Nishi, Tomohiro, additional, Kosugi, Kazuhiro, additional, Shibata, Yasuhiro, additional, Hisanaga, Takayuki, additional, Higashibata, Takahiro, additional, Yabuki, Ritsuko, additional, Hagiwara, Shingo, additional, Shimokawa, Miho, additional, Miyake, Satoshi, additional, Nozato, Junko, additional, Iriyama, Tetsuji, additional, Kaneishi, Keisuke, additional, Baba, Mika, additional, Matsumoto, Yoshihisa, additional, Okizaki, Ayumi, additional, Sumazaki Watanabe, Yuki, additional, uehara, Yuko, additional, Nishijima, Kaoru, additional, Shimoinaba, Junichi, additional, Nakahori, Ryoichi, additional, Hamano, Jun, additional, Kawashima, Natsuki, additional, Kawaguchi, Takashi, additional, Uchida, Megumi, additional, Sato, Ko, additional, Matsuda, Yoichi, additional, Tsuneto, Satoru, additional, Sayaka, Maeda, additional, Kizawa, Yoshiyuki, additional, and Otani, Hiroyuki, additional

Published
2021
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13. Association of the RASS Score With Intensity of Symptoms, Discomfort, and Communication Capacity in Terminally Ill Cancer Patients Receiving Palliative Sedation: Is RASS an Appropriate Outcome Measure?

Author

Imai, Kengo, primary, Morita, Tatsuya, additional, Yokomichi, Naosuke, additional, Mori, Masanori, additional, Naito, Akemi Shirado, additional, Yamauchi, Toshihiro, additional, Tsukuura, Hiroaki, additional, Uneno, Yu, additional, Tsuneto, Satoru, additional, and Inoue, Satoshi, additional

Published
2021
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14. How Successful Is Parenteral Oxycodone for Relieving Terminal Cancer Dyspnea Compared With Morphine? A Multicenter Prospective Observational Study

Author

Mori, Masanori, primary, Kawaguchi, Takashi, additional, Imai, Kengo, additional, Yokomichi, Naosuke, additional, Yamaguchi, Takashi, additional, Suzuki, Kozue, additional, Matsunuma, Ryo, additional, Watanabe, Hiroaki, additional, Maeda, Isseki, additional, Uehara, Yuko, additional, Morita, Tatsuya, additional, Inoue, Satoshi, additional, Mori, Masanori, additional, Tsukuura, Hiroaki, additional, Yamauchi, Toshihiro, additional, Naito, Akemi Shirado, additional, Uneno, Yu, additional, Yoshioka, Akira, additional, Hiramoto, Shuji, additional, Kikuchi, Ayako, additional, Hori, Tetsuo, additional, Matsuda, Yosuke, additional, Kohara, Hiroyuki, additional, Fanaki, Hiromi, additional, Tanaka, Keiko, additional, Kamei, Tina, additional, Azuma, Yukari, additional, Amano, Koji, additional, Uno, Teruaki, additional, Miyamoto, Jiro, additional, Katayama, Hirofumi, additional, Kashiwagi, Hideyuki, additional, Matsumoto, Eri, additional, Oya, Kiyofumi, additional, Yamaguchi, Takeya, additional, Okamura, Tomonao, additional, Hashimoto, Hoshu, additional, Kosugi, Shunsuke, additional, Ikuta, Nao, additional, Matsumoto, Yaichiro, additional, Ohmori, Takashi, additional, Nakai, Takehiro, additional, Ikee, Takashi, additional, Unoki, Yuto, additional, Kitade, Kazuki, additional, Koito, Shu, additional, Ishibashi, Nanao, additional, Ehara, Masaya, additional, Kuwahara, Kosuke, additional, Ueno, Shohei, additional, Nakashima, Shunsuke, additional, Ishiyama, Yuta, additional, Sakashita, Akihiro, additional, Takatsu, Hana, additional, Ito, Satoko, additional, Terabayashi, Toru, additional, Nakagawa, Jun, additional, Yamagiwa, Tetsuya, additional, Inoue, Akira, additional, Yamaguchi, Takuhiro, additional, Miyashita, Mitsunori, additional, Yoshida, Saran, additional, Hiratsuka, Yusuke, additional, Tagami, Keita, additional, Odagiri, Takuya, additional, Ito, Tetsuya, additional, Ikenaga, Masayuki, additional, Shimizu, Keiji, additional, Hayakawa, Akira, additional, Kamura, Rena, additional, Okoshi, Takeru, additional, Nishi, Tomohiro, additional, Kosugi, Kazuhiro, additional, Shibata, Yasuhiro, additional, Hisanaga, Takayuki, additional, Higashibata, Takahiro, additional, Yabuki, Ritsuko, additional, Hagiwara, Shingo, additional, Shimokawa, Miho, additional, Miyake, Satoshi, additional, Nozato, Junko, additional, Ishiki, Hiroto, additional, Iriyama, Tetsuji, additional, Kaneishi, Keisuke, additional, Baba, Mika, additional, Miura, Tomofumi, additional, Matsumoto, Yoshihisa, additional, Okizaki, Ayumi, additional, Watanabe, Yuki Sumazaki, additional, uehara, Yuko, additional, Satomi, Eriko, additional, Nishijima, Kaoru, additional, Shimoinaba, Junichi, additional, Nakahori, Ryoichi, additional, Hirohashi, Takeshi, additional, Hamano, Jun, additional, Kawashima, Natsuki, additional, Uchida, Megumi, additional, Sato, Ko, additional, Matsuda, Yoichi, additional, Hatano, Yutaka, additional, Tsuneto, Satoru, additional, Maeda, Sayaka, additional, Kizawa, Yoshiyuki, additional, and Otani, Hiroyuki, additional

Published
2021
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15. Symptoms, performance status and phase of illness in advanced cancer: multicentre cross-sectional study of palliative care unit admissions

Author

Ohinata, Hironori, Aoyama, Maho, Hiratsuka, Yusuke, Mori, Masanori, Kikuchi, Ayako, Tsukuura, Hiroaki, Matsuda, Yosuke, Suzuki, Kozue, Kohara, Hiroyuki, Maeda, Isseki, Morita, Tatsuya, and Miyashita, Mitsunori

Abstract

ObjectivesTo clarify the relationship between Phase of Illness at the time of admission to palliative care units and symptoms of patients with advanced cancer.MethodsThis study was a secondary analysis of the East Asian collaborative cross-cultural Study to Elucidate the Dying process. Palliative physicians recorded data, including Phase of Illness, physical function and the Integrated Palliative care Outcome Scale. We used multinomial logistic regression to analyse ORs for factors associated with Phase of Illness. Twenty-three palliative care units in Japan participated from January 2017 to September 2018.ResultsIn total, 1894 patients were analysed—50.9% were male, mean age was 72.4 (SD±12.3) years, and Phase of Illness at the time of admission to the palliative care unit comprised 177 (8.9%) stable, 579 (29.2%) unstable, 921 (46.4%) deteriorating and 217 (10.9%) terminal phases. Symptoms were most distressing in the terminal phase for all items, followed by deteriorating, unstable and stable (p<0.001). The stable phase had lower association with shortness of breath (OR 0.73, 95% CI 0.57 to 0.94) and felt at peace (OR 0.73, 95% CI 0.56 to 0.90) than the unstable phase. In the deteriorating phase, weakness or lack of energy (OR 1.20, 95% CI 1.02 to 1.40) were higher, while drowsiness (OR 0.82, 95% CI 0.71 to 0.97) and felt at peace (OR 0.81, 95% CI 0.71 to 0.94) were significantly lower.ConclusionOur study is reflective of the situation in palliative care units in Japan. Future studies should consider the differences in patients’ medical conditions and routinely investigate patients’ Phase of Illness and symptoms.Trial registrarion numberUMIN000025457

Published
2023
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17. Effects of enteral nutrition and parenteral nutrition on survival in patients with advanced cancer cachexia: Analysis of a multicenter prospective cohort study

Author

Amano, Koji, primary, Maeda, Isseki, additional, Ishiki, Hiroto, additional, Miura, Tomofumi, additional, Hatano, Yutaka, additional, Tsukuura, Hiroaki, additional, Taniyama, Tomohiko, additional, Matsumoto, Yoshihisa, additional, Matsuda, Yosuke, additional, Kohara, Hiroyuki, additional, Morita, Tatsuya, additional, Mori, Masanori, additional, Inoue, Satoshi, additional, Yokomichi, Naosuke, additional, Imai, Kengo, additional, Yamauchi, Toshihiro, additional, Naito, Akemi Shirado, additional, Uneno, Yu, additional, Yoshioka, Akira, additional, Hiramoto, Shuji, additional, Kikuchi, Ayako, additional, Hori, Tetsuo, additional, Funaki, Hiromi, additional, Tanaka, Keiko, additional, Suzuki, Kozue, additional, Kamei, Tina, additional, Azuma, Yukari, additional, Uno, Teruaki, additional, Miyamoto, Jiro, additional, Katayama, Hirofumi, additional, Kashiwagi, Hideyuki, additional, Matsumoto, Eri, additional, Oya, Kiyofumi, additional, Yamaguchi, Takeya, additional, Okamura, Tomonao, additional, Hashimoto, Hoshu, additional, Kosugi, Shunsuke, additional, Ikuta, Nao, additional, Matsumoto, Yaichiro, additional, Ohmori, Takashi, additional, Nakai, Takehiro, additional, Ikee, Takashi, additional, Unoki, Yuto, additional, Kitade, Kazuki, additional, Koito, Shu, additional, Ishibashi, Nanao, additional, Ehara, Masaya, additional, Kuwahara, Kosuke, additional, Ueno, Shohei, additional, Nakashima, Shunsuke, additional, Ishiyama, Yuta, additional, Sakashita, Akihiro, additional, Matsunuma, Ryo, additional, Takatsu, Hana, additional, Yamaguchi, Takashi, additional, Ito, Satoko, additional, Terabayashi, Toru, additional, Nakagawa, Jun, additional, Yamagiwa, Tetsuya, additional, Inoue, Akira, additional, Yamaguchi, Takuhiro, additional, Miyashita, Mitsunori, additional, Yoshida, Saran, additional, Hiratsuka, Yusuke, additional, Tagami, Keita, additional, Watanabe, Hiroaki, additional, Odagiri, Takuya, additional, Ito, Tetsuya, additional, Ikenaga, Masayuki, additional, Shimizu, Keiji, additional, Hayakawa, Akira, additional, Kamura, Rena, additional, Okoshi, Takeru, additional, Nishi, Tomohiro, additional, Kosugi, Kazuhiro, additional, Shibata, Yasuhiro, additional, Hisanaga, Takayuki, additional, Higashibata, Takahiro, additional, Yabuki, Ritsuko, additional, Hagiwara, Shingo, additional, Shimokawa, Miho, additional, Miyake, Satoshi, additional, Nozato, Junko, additional, Iriyama, Tetsuji, additional, Kaneishi, Keisuke, additional, Baba, Mika, additional, Okizaki, Ayumi, additional, Watanabe, Yuki Sumazaki, additional, Uehara, Yuko, additional, Satomi, Eriko, additional, Nishijima, Kaoru, additional, Shimoinaba, Junichi, additional, Nakahori, Ryoichi, additional, Hirohashi, Takeshi, additional, Hamano, Jun, additional, Kawashima, Natsuki, additional, Kawaguchi, Takashi, additional, Uchida, Megumi, additional, Sato, Ko, additional, Matsuda, Yoichi, additional, Tsuneto, Satoru, additional, Maeda, Sayaka, additional, Kizawa, Yoshiyuki, additional, and Otani, Hiroyuki, additional

Published
2021
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18. Does Urinary Catheterization Affect the Quality of Death in Patients with Advanced Cancer? A Secondary Analysis of a Multicenter Prospective Cohort Study.

Author

Higashibata, Takahiro, Hamano, Jun, Hisanaga, Takayuki, Hagiwara, Shingo, Shimokawa, Miho, Yabuki, Ritsuko, Yokomichi, Naosuke, Shimoinaba, Junichi, Kamura, Rena, Baba, Mika, Funaki, Hiromi, Mori, Masanori, Morita, Tatsuya, Tsuneto, Satoru, Kizawa, Yoshiyuki, Inoue, Satoshi, Imai, Kengo, Tsukuura, Hiroaki, Yamauchi, Toshihiro, and Naito, Akemi Shirado

Subjects
RESEARCH, LENGTH of stay in hospitals, AGE distribution, URINARY catheterization, MEDICAL cooperation, CANCER patients, SEX distribution, QUALITY of life, DEATH, PALLIATIVE treatment, CANCER patient medical care, SECONDARY analysis, LONGITUDINAL method, PROBABILITY theory
Abstract

Background: Patients with life-limiting illnesses frequently experience urinary difficulties, and urinary catheterization is one of the interventions for managing them. However, evidence supporting the effects of urinary catheters on the quality of death (QoD) is lacking in this population. Objectives: To investigate whether urinary catheterization affects QoD in patients with advanced cancer in palliative care units. Design: A secondary analysis of a multicenter, prospective cohort study. Setting/Subjects: The study enrolled consecutive patients with advanced cancer admitted to palliative care units in Japan between January and December 2017. Those who were not catheterized on admission and who died while in a palliative care unit were analyzed. Measurements: QoD was evaluated at death using the Good Death Scale (GDS). Results: Of 885 patients, 297 (33.6%) were catheterized during their palliative care unit stay. Females and patients with a long palliative care unit stay were more likely to be catheterized. In inverse probability-weighted propensity score analysis, patients with urinary catheterization during their palliative care unit stay had higher total GDS scores than those without catheterization (coefficient 0.410, 95% confidence interval 0.068–0.752). In subgroup analyses stratified by sex, age, and length of palliative care unit stay, urinary catheterization was associated with higher total GDS scores in patients younger than 65 years of age and those who died after a palliative care unit stay of 21 days or fewer. Conclusions: This study suggested that urinary catheterization during a palliative care unit stay may have a positive impact on overall QoD in patients with advanced cancer. This study was registered in the UMIN Clinical Trials Registry (UMIN000025457). [ABSTRACT FROM AUTHOR]

Published
2022
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19. Predictors of duloxetine response in patients with neuropathic cancer pain: a secondary analysis of a randomized controlled trial—JORTC-PAL08 (DIRECT) study

Author

Matsuoka, Hiromichi, primary, Iwase, Satoru, additional, Miyaji, Tempei, additional, Kawaguchi, Takashi, additional, Ariyoshi, Keisuke, additional, Oyamada, Shunsuke, additional, Satomi, Eriko, additional, Ishiki, Hiroto, additional, Hasuo, Hideaki, additional, Sakuma, Hiroko, additional, Tokoro, Akihiro, additional, Matsuda, Yoshinobu, additional, Tahara, Kazuki, additional, Otani, Hiroyuki, additional, Ohtake, Yoichi, additional, Tsukuura, Hiroaki, additional, Matsumoto, Yoshihisa, additional, Hasegawa, Yoshikazu, additional, Kataoka, Yuki, additional, Otsuka, Masatomo, additional, Sakai, Kiyohiro, additional, Nakura, Miki, additional, Morita, Tatsuya, additional, Yamaguchi, Takuhiro, additional, and Koyama, Atsuko, additional

Published
2019
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20. Effects of parenteral nutrition and hydration on survival in advanced cancer patients with malignant bowel obstruction: secondary analysis of a multicenter prospective cohort study.

Author

Arakawa, Sayaka, Amano, Koji, Oyamada, Shunsuke, Maeda, Isseki, Ishiki, Hiroto, Miura, Tomofumi, Hatano, Yutaka, Naito, Akemi Shirado, Sato, Mamiko, Ito, Tetsuya, Kosugi, Kazuhiro, Miyake, Satoshi, Morita, Tatsuya, Mori, Masanori, On Behalf of the East-Asian Collaborative Cross-Cultural Study To Elucidate the Dying Process (EASED) Investigators, Inoue, Satoshi, Yokomichi, Naosuke, Imai, Kengo, Tsukuura, Hiroaki, and Yamauchi, Toshihiro

Subjects
PARENTERAL feeding, BOWEL obstructions, SURVIVAL rate, PROPORTIONAL hazards models, SECONDARY analysis
Abstract

Purpose: The benefits of parenteral nutrition and hydration (PNH) in patients with advanced cancer remain unknown. Therefore, we conducted a prospective multicenter cohort study to assess the effects of PNH on survival in patients with malignant bowel obstruction (MBO). Methods: The present study was a secondary analysis. Data on primary nutritional administration routes during the first week of admission to palliative care units, i.e., parenteral nutrition and parenteral hydration, were obtained. Data on the averaged calorie sufficiency rate/total calorie intake (75% ≤ or 750 kcal/day ≤ , 50–75% or 500–750 kcal/day, 25–50% or 250–500 kcal/day, and < 25% or < 250 kcal/day) were also obtained. Participants with MBO were included and divided into two groups: PNH-high (25% ≤ or 250 kcal/day ≤) and PNH-low (< 25% or < 250 kcal/day). We performed time-to-event analyses using the Kaplan–Meier method, log-rank test, and univariate and multivariate Cox regression analyses. Results: Patients were divided into the PNH-high (n = 68) and PNH-low (n = 76) groups. A significant difference was observed in survival rates between the two groups (log-rank P < 0.001). Median survival times were 35.5 (95% CI 27–44) and 17.5 (95% CI 13–21) days, respectively. In the multivariate-adjusted model, a significantly lower risk of mortality was observed in Cox's proportional hazard model in the PNH-high group (HR 0.55 (95% CI 0.36–0.83), P = 0.005) than in the PNH-low group. Conclusion: The present results indicated the beneficial effects of PNH for prolonging survival in advanced cancer patients with MBO in palliative care units. [ABSTRACT FROM AUTHOR]

Published
2021
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23. A multi-center, randomized, double-blinded, placebo-controlled trial of additive effect of duloxetine for neuropathic cancer pain refractory to opioids and gabapentinoids: JORTC- PAL08 (DIRECT study).

Author

Satomi, Eriko, primary, Matsuoka, Hiromichi, additional, Iwase, Satoru, additional, Miyaji, Tempei, additional, Kawaguchi, Takashi, additional, Ariyoshi, Keisuke, additional, Oyamada, Shunsuke, additional, Hasuo, Hideaki, additional, Tokoro, Akihiro, additional, Shinomiya, Toshiaki, additional, Tsukuura, Hiroaki, additional, Otake, Yoichi, additional, Otsuka, Masatomo, additional, Hasegawa, Yoshikazu, additional, Matsumoto, Yoshihisa, additional, Kataoka, Yuki, additional, Otani, Hiroyuki, additional, Kidera, Yasuhiro, additional, Aoyama, Mayuri, additional, and Yamaguchi, Takuhiro, additional

Published
2018
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25. Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled, Double-Blind Trial

Author

Tsukuura, Hiroaki, primary, Miyazaki, Masayuki, additional, Morita, Tatsuya, additional, Sugishita, Mihoko, additional, Kato, Hiroshi, additional, Murasaki, Yuka, additional, Gyawali, Bishal, additional, Kubo, Yoko, additional, Ando, Masahiko, additional, Kondo, Masashi, additional, Yamada, Kiyofumi, additional, Hasegawa, Yoshinori, additional, and Ando, Yuichi, additional

Published
2017
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28. Efficacy of Prophylactic Treatment for Oxycodone‐Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo‐Controlled, Double‐Blind Trial.

Author

Tsukuura, Hiroaki, Miyazaki, Masayuki, Morita, Tatsuya, Sugishita, Mihoko, Kato, Hiroshi, Murasaki, Yuka, Gyawali, Bishal, Kubo, Yoko, Ando, Masahiko, Kondo, Masashi, Yamada, Kiyofumi, Hasegawa, Yoshinori, and Ando, Yuichi

Subjects
CANCER patients, CANCER pain, HYPERSOMNIA, ORAL drug administration, PLACEBOS, QUALITY of life, OXYCODONE, RANDOMIZED controlled trials, TREATMENT effectiveness, BLIND experiment, SEVERITY of illness index, PASSIVE euthanasia, PROCHLORPERAZINE, THERAPEUTICS
Abstract

Abstract: Background: Although opioid‐induced nausea and vomiting (OINV) often result in analgesic undertreatment in patients with cancer, no randomized controlled trials have evaluated the efficacy of prophylactic antiemetics for preventing OINV. We conducted this randomized, placebo‐controlled, double‐blind trial to evaluate the efficacy and safety of prophylactic treatment with prochlorperazine for preventing OINV. Materials and Methods: Cancer patients who started to receive oral oxycodone were randomly assigned in a 1:1 ratio to receive either prochlorperazine 5 mg or placebo prophylactically, given three times daily for 5 days. The primary endpoint was the proportion of patients who had a complete response (CR) during the 120 hours of oxycodone treatment. CR was defined as no emetic episode and no use of rescue medication for nausea and vomiting during 5 days. Key secondary endpoints were the proportion of patients with emetic episodes, proportion of patients with moderate or severe nausea, quality of life, and proportion of treatment withdrawal. Results: From November 2013 through February 2016, a total of 120 patients were assigned to receive prochlorperazine (n = 60) or placebo (n = 60). There was no significant difference in CR rates (69.5% vs. 63.3%; p = .47) or any secondary endpoint between the groups. Patients who received prochlorperazine were more likely to experience severe somnolence (p = .048). Conclusion: Routine use of prochlorperazine as a prophylactic antiemetic at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations. Implications for Practice: Prophylactic prochlorperazine seems to be ineffective in preventing opioid‐induced nausea and vomiting (OINV) and may cause adverse events such as somnolence. Routine use of prophylactic prochlorperazine at the initiation of treatment with opioids is not recommended. Further research is needed to evaluate whether other antiemetics would be effective in preventing OINV in specific patient populations. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Opioid-induced constipation

Author

Gyawali, Bishal, primary, Hayashi, Naomi, additional, Tsukuura, Hiroaki, additional, Honda, Kazunori, additional, Shimokata, Tomoya, additional, and Ando, Yuichi, additional

Published
2015
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35. The prevalence of artificially administered nutrition and hydration in different age groups among patients with advanced cancer admitted to palliative care units

Author

Amano, Koji, Satomi, Eriko, Oyamada, Shunsuke, Ishiki, Hiroto, Sakashita, Akihiro, Miura, Tomofumi, Maeda, Isseki, Hatano, Yutaka, Yamauchi, Toshihiro, Oya, Kiyofumi, Nakagawa, Jun, Hiratsuka, Yusuke, Hirohashi, Takeshi, Morita, Tatsuya, Mori, Masanori, Inoue, Satoshi, Yokomichi, Naosuke, Imai, Kengo, Tsukuura, Hiroaki, Naito, Akemi Shirado, Uneno, Yu, Yoshioka, Akira, Hiramoto, Shuji, Kikuchi, Ayako, Hori, Tetsuo, Matsuda, Yosuke, Kohara, Hiroyuki, Funaki, Hiromi, Tanaka, Keiko, Suzuki, Kozue, Kamei, Tina, Azuma, Yukari, Uno, Teruaki, Miyamoto, Jiro, Katayama, Hirofumi, Kashiwagi, Hideyuki, Matsumoto, Eri, Yamaguchi, Takeya, Okamura, Tomonao, Hashimoto, Hoshu, Kosugi, Shunsuke, Ikuta, Nao, Matsumoto, Yaichiro, Ohmori, Takashi, Nakai, Takehiro, Ikee, Takashi, Unoki, Yuto, Kitade, Kazuki, Koito, Shu, Ishibashi, Nanao, Ehara, Masaya, Kuwahara, Kosuke, Ueno, Shohei, Nakashima, Shunsuke, Ishiyama, Yuta, Matsunuma, Ryo, Takatsu, Hana, Yamaguchi, Takashi, Ito, Satoko, Terabayashi, Toru, Yamagiwa, Tetsuya, Inoue, Akira, Yamaguchi, Takuhiro, Miyashita, Mitsunori, Yoshida, Saran, Tagami, Keita, Watanabe, Hiroaki, Odagiri, Takuya, Ito, Tetsuya, Ikenaga, Masayuki, Shimizu, Keiji, Hayakawa, Akira, Kamura, Rena, Okoshi, Takeru, Nishi, Tomohiro, Kosugi, Kazuhiro, Shibata, Yasuhiro, Hisanaga, Takayuki, Higashibata, Takahiro, Yabuki, Ritsuko, Hagiwara, Shingo, Shimokawa, Miho, Miyake, Satoshi, Nozato, Junko, Iriyama, Tetsuji, Kaneishi, Keisuke, Baba, Mika, Matsumoto, Yoshihisa, Okizaki, Ayumi, Sumazaki Watanabe, Yuki, uehara, Yuko, Nishijima, Kaoru, Shimoinaba, Junichi, Nakahori, Ryoichi, Hamano, Jun, Kawashima, Natsuki, Kawaguchi, Takashi, Uchida, Megumi, Sato, Ko, Matsuda, Yoichi, Tsuneto, Satoru, Maeda, Sayaka, Kizawa, Yoshiyuki, and Otani, Hiroyuki

Abstract

The prevalence of artificially administered nutrition and hydration (AANH) in different age groups among patients with advanced cancer remains unknown. The present study investigated the current utilization of AANH according to age groups in palliative care units.

Published
2021
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36. Symptoms, performance status and phase of illness in advanced cancer: multicentre cross-sectional study of palliative care unit admissions.

Author

Ohinata H, Aoyama M, Hiratsuka Y, Mori M, Kikuchi A, Tsukuura H, Matsuda Y, Suzuki K, Kohara H, Maeda I, Morita T, and Miyashita M

Subjects
Aged, Female, Humans, Male, Cross-Sectional Studies, Hospitalization, Logistic Models, Middle Aged, Aged, 80 and over, Neoplasms complications, Neoplasms therapy, Palliative Care
Abstract

Objectives: To clarify the relationship between Phase of Illness at the time of admission to palliative care units and symptoms of patients with advanced cancer., Methods: This study was a secondary analysis of the East Asian collaborative cross-cultural Study to Elucidate the Dying process. Palliative physicians recorded data, including Phase of Illness, physical function and the Integrated Palliative care Outcome Scale. We used multinomial logistic regression to analyse ORs for factors associated with Phase of Illness. Twenty-three palliative care units in Japan participated from January 2017 to September 2018., Results: In total, 1894 patients were analysed-50.9% were male, mean age was 72.4 (SD±12.3) years, and Phase of Illness at the time of admission to the palliative care unit comprised 177 (8.9%) stable, 579 (29.2%) unstable, 921 (46.4%) deteriorating and 217 (10.9%) terminal phases. Symptoms were most distressing in the terminal phase for all items, followed by deteriorating, unstable and stable (p<0.001). The stable phase had lower association with shortness of breath (OR 0.73, 95% CI 0.57 to 0.94) and felt at peace (OR 0.73, 95% CI 0.56 to 0.90) than the unstable phase. In the deteriorating phase, weakness or lack of energy (OR 1.20, 95% CI 1.02 to 1.40) were higher, while drowsiness (OR 0.82, 95% CI 0.71 to 0.97) and felt at peace (OR 0.81, 95% CI 0.71 to 0.94) were significantly lower., Conclusion: Our study is reflective of the situation in palliative care units in Japan. Future studies should consider the differences in patients' medical conditions and routinely investigate patients' Phase of Illness and symptoms., Trial Registrarion Number: UMIN000025457., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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