Search

Your search keyword '"Tsujimoto, Shinichi"' showing total 28 results
Start Over Author "Tsujimoto, Shinichi"
28 results on '"Tsujimoto, Shinichi"'

2. KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Author

Iyoda, Shinju, Yoshida, Kenichi, Shoji, Kota, Ito, Nana, Tanaka, Miu, Nannya, Yasuhito, Yamato, Genki, Tsujimoto, Shinichi, Shiba, Norio, Hayashi, Yasuhide, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Okada, Ai, Tanaka, Hiroko, Miyano, Satoru, Koga, Yuhki, Goto, Hiroaki, Moritake, Hiroshi, Terui, Kiminori, Ito, Etsuro, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Taga, Takashi, Tawa, Akio, Takita, Junko, Nishikori, Momoko, Adachi, Souichi, Ogawa, Seishi, and Matsuo, Hidemasa

Published
2024
Full Text
View/download PDF

3. Formation of an ultracarbonaceous Antarctic micrometeorite through minimal aqueous alteration in a small porous icy body

Author

Yabuta, Hikaru, Noguchi, Takaaki, Itoh, Shoichi, Nakamura, Tomoki, Miyake, Akira, Tsujimoto, Shinichi, Ohashi, Noriaki, Sakamoto, Naoya, Hashiguchi, Minako, Abe, Ken-ichi, Okubo, Aya, Kilcoyne, AL David, Tachibana, Shogo, Okazaki, Ryuji, Terada, Kentaro, Ebihara, Mitsuru, and Nagahara, Hiroko

Subjects
Earth Sciences, Geology, Ultracarbonaceous Antarctic micrometeorites, Organic matter, GEMS, Aqueous alteration, Comet, Shock, SIMS, XANES, TEM, Geochemistry, Physical Geography and Environmental Geoscience, Geochemistry & Geophysics
Abstract

A comprehensive study of the organic chemistry and mineralogy of an ultracarbonaceous micrometeorite (UCAMM D05IB80) collected from near the Dome Fuji Station, Antarctica, was carried out to understand the genetic relationship among organic materials, silicates, and water. The micrometeorite is composed of a dense aggregate of ∼5 µm-sized hollow ellipsoidal organic material containing submicrometer-sized phases such as glass with embedded metal and sulfides (GEMS) and mineral grains. There is a wide area of organic material (∼15 × 15 μm) in its interior. Low-Ca pyroxene is much more abundant than olivine and shows various Mg/(Mg + Fe) ratios ranging from ∼1.0 to 0.78, which is common to previous works on UCAMMs. By contrast, GEMS grains in this UCAMM have unusual chemical compositions. They are depleted in both Mg and S, which suggests that these elements were leached out from the GEMS grains during very weak aqueous alteration, without the formation of phyllosilicates. The organic materials have two textures—smooth and globular with an irregular outline—and these are composed of imine, nitrile and/or aromatic nitrogen heterocycles, and amide. The ratio of nitrogen to carbon (N/C) in the smooth region of the organics is ∼0.15, which is five times higher than that of insoluble organic macromolecules in types 1 and 2 carbonaceous chondritic meteorites. In addition, the UCAMM organic materials are soluble in epoxy and are thus hydrophilic; this polar nature indicates that they are very primitive. The surface of the material is coated with an inorganic layer, a few nanometers thick, that consists of C, O, Si, S, and Fe. Sulfur is also contained in the interior, implying the presence of organosulfur moieties. There are no isotopic anomalies of D, 13C, or 15N in the organic material. Interstellar photochemistry alone would not be sufficient to explain the N/C ratio of the UCAMM organics; therefore, we suggest that a very small amount of fluid on a comet must have been necessary for the formation of the UCAMM. The GEMS grains depleted in Mg and S in the UCAMM prove a very weak degree of aqueous alteration; weaker than that of carbonaceous chondrites. Short-duration weak alteration probably caused by planetesimal shock locally melted cometary ice grains and released water that dissolved the organics; the fluid would likely have not mobilized because of the very low thermal conductivity of the porous icy body. This event allowed the formation of the large organic puddle of the UCAMM, as well as organic matter sulfurization, formation of thin membrane-like layers of minerals, and deformation of organic nanoglobules.

Published
2017

4. A Case of Myxoid Pleomorphic Liposarcoma with Rhabdoid Cells: A Diagnostic Pitfall.

Author

Arai, Takuma, Kato, Ikuma, Kawabata, Yusuke, Tsujimoto, Shinichi, Ishikawa, Yoshihiro, Kato, Shingo, Takeyama, Masanobu, Yamanaka, Shoji, Kohashi, Kenichi, Oda, Yoshinao, and Fujii, Satoshi

Subjects
FLUORESCENCE in situ hybridization, GROIN, CHEST (Anatomy), ADJUVANT chemotherapy, LIPOSARCOMA
Abstract

Myxoid pleomorphic liposarcoma (MPLS) is an extremely rare tumor listed in the fifth edition of the WHO classification (2020). Histologically, it mainly comprises a mixture of myxoid and pleomorphic liposarcoma-like components. Genetically, it lacks FUS/EWSR1::DDIT3 fusion and MDM2 amplification. Herein, we describe an example of MPLS with rhabdoid cells in a 10-year-old girl who presented with a growing mass in the right inguinal region. The specimen from the wide excision measured 68 mm × 55 mm × 43 mm, and a circumscribed and lobulated mass was observed in the subcutaneous tissue. Histologically, oval-to-short, spindle-shaped, proliferating tumor cells with moderate nuclear atypia and mesh-like capillaries against a myxoid background were noted. Adipocytes were observed focally, while rhabdoid cells were observed multifocally. Immunohistochemically, the tumor showed inconsistent reactivity for desmin but was negative for MYOD1, myogenin, MDM2, and CDK4. Fluorescence in situ hybridization revealed no DDIT3 rearrangement. Despite adjuvant chemotherapy, the tumor metastasized to the thoracic cavity 24 months after excision. The metastatic lesions contained abundant lipoblasts rather than rhabdoid cells, and we concluded this tumor was a MPLS. The presence of rhabdoid cells could be a diagnostic pitfall, and recognizing such a variation in histology would help improve diagnostic accuracy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core‐binding factor

Author

Aoki, Takahiro, primary, Shiba, Norio, additional, Tsujimoto, Shinichi, additional, Yamato, Genki, additional, Hara, Yusuke, additional, Kato, Shota, additional, Yoshida, Kenichi, additional, Ogawa, Seishi, additional, Hayashi, Yasuhide, additional, Iwamoto, Shotaro, additional, Taki, Tomohiko, additional, Shimada, Akira, additional, Iijima‐Yamashita, Yuka, additional, Horibe, Keizo, additional, Tawa, Akio, additional, Taga, Takashi, additional, Adachi, Souichi, additional, and Tomizawa, Daisuke, additional

Published
2023
Full Text
View/download PDF

6. Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms

Author

Tsujimoto, Shinichi, Osumi, Tomoo, Uchiyama, Meri, Shirai, Ryota, Moriyama, Takaya, Nishii, Rina, Yamada, Yuji, Kudo, Ko, Sekiguchi, Masahiro, Arakawa, Yuki, Yoshida, Masanori, Uchiyama, Toru, Terui, Kiminori, Ito, Shuichi, Koh, Katsuyoshi, Takita, Junko, Ito, Etsuro, Tomizawa, Daisuke, Manabe, Atsushi, Kiyokawa, Nobutaka, Yang, Jun J., and Kato, Motohiro

Published
2018
Full Text
View/download PDF

8. KRASG12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia

Author

Iyoda, Shinju, Yoshida, Kenichi, Shoji, Kota, Ito, Nana, Tanaka, Miu, Nannya, Yasuhito, Yamato, Genki, Tsujimoto, Shinichi, Shiba, Norio, Hayashi, Yasuhide, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Okada, Ai, Tanaka, Hiroko, Miyano, Satoru, Koga, Yuhki, Goto, Hiroaki, Moritake, Hiroshi, Terui, Kiminori, Ito, Etsuro, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Taga, Takashi, Tawa, Akio, Takita, Junko, Nishikori, Momoko, Adachi, Souichi, Ogawa, Seishi, and Matsuo, Hidemasa

Published
2024
Full Text
View/download PDF

9. Droplet digital polymerase chain reaction assay for the detection of the minor clone of KIT D816V in paediatric acute myeloid leukaemia especially showing RUNX1‐RUNX1T1 transcripts

Author

Sasaki, Koji, primary, Tsujimoto, Shinichi, additional, Miyake, Mayuko, additional, Uchiyama, Yuri, additional, Ikeda, Junji, additional, Yoshitomi, Masahiro, additional, Shimosato, Yuko, additional, Tokumasu, Mayu, additional, Matsuo, Hidemasa, additional, Yoshida, Kenichi, additional, Ohki, Kentaro, additional, Kaburagi, Taeko, additional, Yamato, Genki, additional, Hara, Yusuke, additional, Takeuchi, Masanobu, additional, Kinoshita, Akitoshi, additional, Tomizawa, Daisuke, additional, Taga, Takashi, additional, Adachi, Souichi, additional, Tawa, Akio, additional, Horibe, Keizo, additional, Hayashi, Yasuhide, additional, Matsumoto, Naomichi, additional, Ito, Shuichi, additional, and Shiba, Norio, additional

Published
2021
Full Text
View/download PDF

10. ATRT-11. PREVALENCE OF GERMLINE VARIANTS IN SMARCB1 INCLUDING SOMATIC MOSAICISM IN AT/RT AND OTHER RHABDOID TUMORS

Author

Shirai, Ryota, primary, Osumi, Tomoo, additional, Terashima, Keita, additional, Kiyotani, Chikako, additional, Uchiyama, Meri, additional, Tsujimoto, Shinichi, additional, Yoshida, Masanori, additional, Yoshida, Kaoru, additional, Uchiyama, Toru, additional, Tomizawa, Daisuke, additional, Shioda, Yoko, additional, Sekiguchi, Masahiro, additional, Watanabe, Kenichiro, additional, Keino, Dai, additional, Ueno-Yokohata, Hitomi, additional, Ohki, Kentaro, additional, Takita, Junko, additional, Ito, Shuichi, additional, Deguchi, Takao, additional, Kiyokawa, Nobutaka, additional, Ogiwara, Hideki, additional, Hishiki, Tomoro, additional, Ogawa, Seishi, additional, Okita, Hajime, additional, Matsumoto, Kimikazu, additional, Yoshioka, Takako, additional, and Kato, Motohiro, additional

Published
2020
Full Text
View/download PDF

11. ETMR-11. A CASE OF PRIMARY DIFFUSE LEPTOMENINGEAL PRIMITIVE NEUROECTODERMAL TUMOR

Author

Sugawa, Masahiro, primary, Terashima, Keita, additional, Matsukawa, Yukihiro, additional, Mizuno, Takanori, additional, Isshiki, Kyohei, additional, Tsujimoto, Shinichi, additional, Uchiyama, Meri, additional, Sakamoto, Kenichi, additional, Gocho, Yoshihiro, additional, Osumi, Tomoo, additional, Shioda, Yoko, additional, Kiyotani, Chikako, additional, Kato, Motohiro, additional, Tomizawa, Daisuke, additional, Usami, Kenichi, additional, Ogiwara, Hideki, additional, Tsutsumi, Yoshiaki, additional, Nakano, Masayuki, additional, Yoshioka, Takako, additional, and Matsumoto, Kimikazu, additional

Published
2020
Full Text
View/download PDF

12. High prevalence of SMARCB1 constitutional abnormalities including mosaicism in malignant rhabdoid tumors

Author

Shirai, Ryota, primary, Osumi, Tomoo, additional, Terashima, Keita, additional, Kiyotani, Chikako, additional, Uchiyama, Meri, additional, Tsujimoto, Shinichi, additional, Yoshida, Masanori, additional, Yoshida, Kaoru, additional, Uchiyama, Toru, additional, Tomizawa, Daisuke, additional, Shioda, Yoko, additional, Sekiguchi, Masahiro, additional, Watanabe, Kenichiro, additional, Keino, Dai, additional, Ueno-Yokohata, Hitomi, additional, Ohki, Kentaro, additional, Takita, Junko, additional, Ito, Shuichi, additional, Deguchi, Takao, additional, Kiyokawa, Nobutaka, additional, Ogiwara, Hideki, additional, Hishiki, Tomoro, additional, Ogawa, Seishi, additional, Okita, Hajime, additional, Matsumoto, Kimikazu, additional, Yoshioka, Takako, additional, and Kato, Motohiro, additional

Published
2020
Full Text
View/download PDF

13. PEDT-04 SIX CASES OF RETINOBLASTOMA WITH CNS INVOLVEMENT

Author

Kiyotani, Chikako, primary, Tsujimoto, Shinichi, additional, Isshiki, Kyohei, additional, Sugawa, Masahiro, additional, Azuma, Noriyuki, additional, Usami, Kenichi, additional, Ogiwara, Hideki, additional, Yosioka, Takako, additional, Tsutsumi, Yoshiyuki, additional, Fuji, Hiroshi, additional, Terashima, Keita, additional, and Matsumoto, Kimikazu, additional

Published
2019
Full Text
View/download PDF

14. NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Author

Yoshida, Masanori, primary, Nakabayashi, Kazuhiko, additional, Sato-Otsubo, Aiko, additional, Tsujimoto, Shinichi, additional, Yoshida, Kaoru, additional, Shirai, Ryota, additional, Osumi, Tomoo, additional, Yuza, Yuki, additional, Takagi, Masatoshi, additional, Takahashi, Hiroyuki, additional, Koh, Katsuyoshi, additional, Kinoshita, Akitoshi, additional, Hino, Moeko, additional, Imamura, Toshihiko, additional, Nakazawa, Yozo, additional, Mayuko, Okuya, additional, Kakuda, Harumi, additional, Sanada, Masashi, additional, Matsumoto, Kimikazu, additional, Tomizawa, Daisuke, additional, Kiyokawa, Nobutaka, additional, Ohara, Akira, additional, Manabe, Atsushi, additional, Hata, Kenichiro, additional, Yang, Jun J., additional, and Kato, Motohiro, additional

Published
2019
Full Text
View/download PDF

15. Preoperative diagnosis of clear cell sarcoma of the kidney by detection of BCOR internal tandem duplication in circulating tumor DNA

Author

Ueno-Yokohata, Hitomi, primary, Okita, Hajime, additional, Nakasato, Keiko, additional, Hishiki, Tomoro, additional, Shirai, Ryota, additional, Tsujimoto, Shinichi, additional, Osumi, Tomoo, additional, Yoshimura, Satoshi, additional, Yamada, Yuji, additional, Shioda, Yoko, additional, Kiyotani, Chikako, additional, Terashima, Keita, additional, Miyazaki, Osamu, additional, Matsumoto, Kimikazu, additional, Kiyokawa, Nobutaka, additional, Yoshioka, Takako, additional, and Kato, Motohiro, additional

Published
2018
Full Text
View/download PDF

16. Space Weathered Rims Found on the Surfaces of the Itokawa Dust Particles

Author

Zolensky, Michael E., Sagae, Ryosuke, Tsujimoto, Shinichi, Noguchi, Takaaki, Kimura, Makoto, Hashimoto, Takahito, Konno, Mitsuru, Nakamura, Tomoki, Okazaki, Ryuji, Tanaka, Masahiko, Tsuchiyama, Akira, Nakato, Aiko, Ogami, Toshinori, Ishida, Hatsumi, Matsumoto, Toru, Matsuno, Junya, Fujimura, Akio, Abe, Masanao, Yada, Toru, Mukai, Toshifumi, Ueno, Munetaka, Okada, Tatsuaki, Shirai, Kei, and Ishibashi, Yukihiro

Subjects
Metal, Geophysics, Space and Planetary Science, Sputtering, visual_art, Dust particles, Composite number, visual_art.visual_art_medium, Surface modification, Mineralogy, Space weathering, Reflectivity, Geology
Abstract

著者人数: 24名, Accepted: 2013-03-05, 資料番号: SA1140052000

Published
2014

19. Formation of an ultracarbonaceous Antarctic micrometeorite through minimal aqueous alteration in a small porous icy body

Author

Yabuta, Hikaru, primary, Noguchi, Takaaki, additional, Itoh, Shoichi, additional, Nakamura, Tomoki, additional, Miyake, Akira, additional, Tsujimoto, Shinichi, additional, Ohashi, Noriaki, additional, Sakamoto, Naoya, additional, Hashiguchi, Minako, additional, Abe, Ken-ichi, additional, Okubo, Aya, additional, Kilcoyne, A.L. David, additional, Tachibana, Shogo, additional, Okazaki, Ryuji, additional, Terada, Kentaro, additional, Ebihara, Mitsuru, additional, and Nagahara, Hiroko, additional

Published
2017
Full Text
View/download PDF

20. High prevalence of SMARCB1constitutional abnormalities including mosaicism in malignant rhabdoid tumors

Author

Shirai, Ryota, Osumi, Tomoo, Terashima, Keita, Kiyotani, Chikako, Uchiyama, Meri, Tsujimoto, Shinichi, Yoshida, Masanori, Yoshida, Kaoru, Uchiyama, Toru, Tomizawa, Daisuke, Shioda, Yoko, Sekiguchi, Masahiro, Watanabe, Kenichiro, Keino, Dai, Ueno-Yokohata, Hitomi, Ohki, Kentaro, Takita, Junko, Ito, Shuichi, Deguchi, Takao, Kiyokawa, Nobutaka, Ogiwara, Hideki, Hishiki, Tomoro, Ogawa, Seishi, Okita, Hajime, Matsumoto, Kimikazu, Yoshioka, Takako, and Kato, Motohiro

Abstract

Intensive analysis of the SMARCB1gene in malignant rhabdoid tumors (MRT) revealed eight of 16 patients with constitutional genetic variants. Three patients had mosaicism of deletion/variant of the SMARCB1gene, which conventional methods might overlook. The prevalence of cancer predisposition in MRT may thus be higher than previously reported.

Published
2020
Full Text
View/download PDF

21. Risk factors for psychological and psychosomatic symptoms among children with malignancies.

Author

Maeda, Kenichi, Hasegawa, Daisuke, Urayama, Kevin Y., Tsujimoto, Shinichi, Azami, Yuriko, Ozawa, Miwa, and Manabe, Atsushi

Subjects
TUMORS in children, PEDIATRICS, HOSPITAL care, PSYCHOSOMATIC disorders, STEM cell transplantation
Abstract

Aim: With increasing survival rates in paediatric malignancies, the quality-of-life of children during hospitalisation should be given more attention. We aimed to identify factors associated with psychological and psychosomatic symptoms (PPS) that required medication among children hospitalised for treatment of malignancies.Methods: We retrospectively analysed data of 190 patients aged 2-18 years old. They were diagnosed with malignant diseases and admitted for treatment at St. Luke's International Hospital between 2003 and 2013. Patients were considered as having PPS if they were prescribed psychotropic agents during hospitalisation.Results: Of the 190 patients, 56 (30%) were prescribed psychotropic agents for PPS. Types of PPS included insomnia in 21 (38%), anxiety in 11 (20%), and others conditions (psychogenetic nausea, agitation, delirium, depression). The most prescribed psychotropic agents were etizolam for 34 cases (61%), followed by diazepam and risperidone. The multivariable analyses confirmed statistically significant independent associations for haematopoietic stem cell transplantation (HSCT) (odds ratio (OR), 5.21; 95% confidence interval (CI), 1.77-15.35), older age (12-18 years vs. 2-5 years, OR, 3.74; 95% CI, 1.04-10.00), and opioid use (OR, 7.15; 95% CI, 2.36-21.69).Conclusions: Older age at admission, undergoing HSCT, and those given opioids were found to be risk factors for PPS among children with malignancies. Appropriate preventive measures against PPS may be warranted for patients with these risk factors. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

22. Space Weathered Rims Found on the Surfaces of the Itokawa Dust Particles

Author

野口, 高明, 木村, 眞, 橋本, 隆仁, 今野, 充, 中村, 智樹, Zolensky, Michael E., 岡崎, 隆司, 田中, 雅彦, 土山, 明, 中藤, 亜衣子, 大神, 稔皓, 石田, 初美, Sagae, Ryosuke, Tsujimoto, Shinichi, 松本, 徹, 松野, 淳也, 藤村, 彰夫, 安部, 正真, 矢田, 達, 向井, 利典, 上野, 宗孝, 岡田, 達明, 白井, 慶, 石橋, 之宏, Noguchi, Takaaki, Kimura, Makoto, Hashimoto, Takahito, Konno, Mitsuru, Nakamura, Tomoki, Okazaki, Ryuji, Tanaka, Masahiko, Tsuchiyama, Akira, Nakato, Aiko, Ogami, Toshinori, Ishida, Hatsumi, Matsumoto, Toru, Matsuno, Junya, Fujimura, Akio, Abe, Masanao, Yada, Toru, Mukai, Toshifumi, Ueno, Munetaka, Okada, Tatsuaki, Shirai, Kei, Ishibashi, Yukihiro, 野口, 高明, 木村, 眞, 橋本, 隆仁, 今野, 充, 中村, 智樹, Zolensky, Michael E., 岡崎, 隆司, 田中, 雅彦, 土山, 明, 中藤, 亜衣子, 大神, 稔皓, 石田, 初美, Sagae, Ryosuke, Tsujimoto, Shinichi, 松本, 徹, 松野, 淳也, 藤村, 彰夫, 安部, 正真, 矢田, 達, 向井, 利典, 上野, 宗孝, 岡田, 達明, 白井, 慶, 石橋, 之宏, Noguchi, Takaaki, Kimura, Makoto, Hashimoto, Takahito, Konno, Mitsuru, Nakamura, Tomoki, Okazaki, Ryuji, Tanaka, Masahiko, Tsuchiyama, Akira, Nakato, Aiko, Ogami, Toshinori, Ishida, Hatsumi, Matsumoto, Toru, Matsuno, Junya, Fujimura, Akio, Abe, Masanao, Yada, Toru, Mukai, Toshifumi, Ueno, Munetaka, Okada, Tatsuaki, Shirai, Kei, and Ishibashi, Yukihiro

Abstract

著者人数: 24名, Accepted: 2013-03-05

Published
2015

23. RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Author

Kato, Motohiro, Osumi, Tomoo, Tsujimoto, Shinichi, Tamura, Moe, Uchiyama, Meri, Nakabayashi, Kazuhiko, Okamura, Kohji, Tomizawa, Daisuke, Watanabe, Akihiro, Takahashi, Hiroyuki, Hori, Tsukasa, Yamamoto, Shohei, Hamamoto, Kazuko, Migita, Masahiro, Ogata-Kawata, Hiroko, Uchiyama, Toru, Kizawa, Hiroe, Ueno-Yokohata, Hitomi, Shirai, Ryota, Yoshida, Masanori, Seki, Masafumi, Oki, Kentaro, Takita, Junko, Ogawa, Seishi, Kitamura, Toshio, Matsumoto, Kimikazu, Hata, Kenichiro, Goyama, Susumu, and Kiyokawa, Nobutaka

Published
2017
Full Text
View/download PDF

24. Diplotype analysis of NUDT15variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms

Author

Tsujimoto, Shinichi, Osumi, Tomoo, Uchiyama, Meri, Shirai, Ryota, Moriyama, Takaya, Nishii, Rina, Yamada, Yuji, Kudo, Ko, Sekiguchi, Masahiro, Arakawa, Yuki, Yoshida, Masanori, Uchiyama, Toru, Terui, Kiminori, Ito, Shuichi, Koh, Katsuyoshi, Takita, Junko, Ito, Etsuro, Tomizawa, Daisuke, Manabe, Atsushi, Kiyokawa, Nobutaka, Yang, Jun J., and Kato, Motohiro

Published
2018
Full Text
View/download PDF

25. Space weathered rims found on the surfaces of the Itokawa dust particles

Author

Noguchi, Takaaki, primary, Kimura, Makoto, additional, Hashimoto, Takahito, additional, Konno, Mitsuru, additional, Nakamura, Tomoki, additional, Zolensky, Michael E., additional, Okazaki, Ryuji, additional, Tanaka, Masahiko, additional, Tsuchiyama, Akira, additional, Nakato, Aiko, additional, Ogami, Toshinori, additional, Ishida, Hatsumi, additional, Sagae, Ryosuke, additional, Tsujimoto, Shinichi, additional, Matsumoto, Toru, additional, Matsuno, Junya, additional, Fujimura, Akio, additional, Abe, Masanao, additional, Yada, Toru, additional, Mukai, Toshifumi, additional, Ueno, Munetaka, additional, Okada, Tatsuaki, additional, Shirai, Kei, additional, and Ishibashi, Yukihiro, additional

Published
2013
Full Text
View/download PDF

26. Space weathered rims found on the surfaces of the Itokawa dust particles.

Author

Noguchi, Takaaki, Kimura, Makoto, Hashimoto, Takahito, Konno, Mitsuru, Nakamura, Tomoki, Zolensky, Michael E., Okazaki, Ryuji, Tanaka, Masahiko, Tsuchiyama, Akira, Nakato, Aiko, Ogami, Toshinori, Ishida, Hatsumi, Sagae, Ryosuke, Tsujimoto, Shinichi, Matsumoto, Toru, Matsuno, Junya, Fujimura, Akio, Abe, Masanao, Yada, Toru, and Mukai, Toshifumi

Subjects
ITOKAWA (Asteroid), DUST, LAYER structure (Solids), SPECTRUM analysis, OPTICAL reflection, SOLAR wind, WEATHERING
Abstract

On the basis of observations using Cs-corrected STEM, we identified three types of surface modification probably formed by space weathering on the surfaces of Itokawa particles. They are (1) redeposition rims (2-3 nm), (2) composite rims (30-60 nm), and (3) composite vesicular rims (60-80 nm). These rims are characterized by a combination of three zones. Zone I occupies the outermost part of the surface modification, which contains elements that are not included in the unchanged substrate minerals, suggesting that this zone is composed of sputter deposits and/or impact vapor deposits originating from the surrounding minerals. Redeposition rims are composed only of Zone I and directly attaches to the unchanged minerals (Zone III). Zone I of composite and composite vesicular rims often contains nanophase (Fe,Mg)S. The composite rims and the composite vesicular rims have a two-layered structure: a combination of Zone I and Zone II, below which Zone III exists. Zone II is the partially amorphized zone. Zone II of ferromagnesian silicates contains abundant nanophase Fe. Radiation-induced segregation and in situ reduction are the most plausible mechanisms to form nanophase Fe in Zone II. Their lattice fringes indicate that they contain metallic iron, which probably causes the reddening of the reflectance spectra of Itokawa. Zone II of the composite vesicular rims contains vesicles. The vesicles in Zone II were probably formed by segregation of solar wind He implanted in this zone. The textures strongly suggest that solar wind irradiation damage and implantation are the major causes of surface modification and space weathering on Itokawa. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

27. NUDT15Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Author

Yoshida, Masanori, Nakabayashi, Kazuhiko, Sato-Otsubo, Aiko, Tsujimoto, Shinichi, Yoshida, Kaoru, Shirai, Ryota, Osumi, Tomoo, Yuza, Yuki, Takagi, Masatoshi, Takahashi, Hiroyuki, Koh, Katsuyoshi, Kinoshita, Akitoshi, Hino, Moeko, Imamura, Toshihiko, Nakazawa, Yozo, Mayuko, Okuya, Kakuda, Harumi, Sanada, Masashi, Matsumoto, Kimikazu, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Ohara, Akira, Manabe, Atsushi, Hata, Kenichiro, Yang, Jun J., and Kato, Motohiro

Abstract

Background: Secondary or subsequent malignant neoplasms (SMNs) are one of the most serious late complications in children and adolescents after treatment for acute lymphoblastic leukemia (ALL). Several studies have reported that excess dosing of 6-mercaptopurine (6-MP) therapy and polymorphisms of 6-MP metabolizing enzyme coding gene might influence the risk of SMNs. Recently, nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants have been identified as a cause of high sensitivity to 6-MP, which reflects a high sensitivity to 6MP in East Asians. Therefore, we investigated an association between NUDT15genotype and incidence of SMNs in pediatric ALL.

Published
2019
Full Text
View/download PDF

28. RARBTranslocations in Acute Promyelocytic Leukemia without Raratranslocation

Author

Kato, Motohiro, Osumi, Tomoo, Tsujimoto, Shinichi, Tamura, Moe, Uchiyama, Meri, Nakabayashi, Kazuhiko, Okamura, Kohji, Tomizawa, Daisuke, Watanabe, Akihiro, Takahashi, Hiroyuki, Hori, Tsukasa, Yamamoto, Shohei, Hamamoto, Kazuko, Migita, Masahiro, Ogata-Kawata, Hiroko, Uchiyama, Toru, Kizawa, Hiroe, Ueno-Yokohata, Hitomi, Shirai, Ryota, Yoshida, Masanori, Seki, Masafumi, Oki, Kentaro, Takita, Junko, Ogawa, Seishi, Kitamura, Toshio, Matsumoto, Kimikazu, Hata, Kenichiro, Goyama, Susumu, and Kiyokawa, Nobutaka

Abstract

Introduction: Acute promyelocytic leukemia (APL) is defined by unique morphological features, typically abnormal promyelocytes containing azurophilic granules. Genomic basis of APL is characterized by the translocation t(15;17)(q22;q21), inducing fusions between promyelocytic leukemia (PML) and retinoic acid receptor-a (RARA). APL cells with PML-RARA respond to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), and recent clinical trials have achieved excellent outcome for typical APL with PML-RARA. Although a certain fraction of APL cases lacks PMR-RARA, most of them had translocation including RARAand other genes, namely, PLZF, NPM, and TBL1XR1. Eventually, all known APL-associated translocations involve RARA, accounting for 99% of APL. However, RARArearrangement is unable to be detected in the rest of APL cases, and molecular mechanisms underlying this small subset is still unclear. We here analyzed APL cases without RARAtranslocation, and identified a novel RARBfusion in the majority of patients with RARA-negative APL.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results