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1. Physical and biological properties of a novel anti-adhesive punctate uneven gelatin film.

Author

Ozamoto, Yuki, Horii, Tsunehito, Morita, Shinichiro, Tsujimoto, Hiroyuki, Oe, Yasumitsu, Minato, Hiroshi, Ueda, Joe, Ichikawa, Hiroshi, Kawauchi, Akihiro, Hagiwara, Akeo, Kageyama, Susumu, and Tani, Masaji

Abstract

Since abdominal adhesion are quite problematic in abdominal and pelvic surgery, the conventional HA/CMC film are commonly used as an anti-adhesive material. However, such types are difficult to be rolled and delivered through the port of laparoscopic surgical devices due to adherence to the laparoscopic port or other parts of the films. To create an anti-adhesion film with more favorable handling properties and anti-adhesive effect, we developed a novel punctate uneven gelatin film (PU GF). In this study, we examined the physical strength, flexibilities and adhesiveness between film to tissues or film each other, compared to the conventional film and the flat gelatin film (Flat GF). In addition, we investigated the cell proliferation on each film and the anti-adhesive effect of the films and those reattachment possibility using a rat cecum abrasion model. The PU GF showed excellent tensile strength, ductility, and adherence to tissue compared to Flat GF and the conventional film. Moreover, the adherence of PU GF to the other film and to a silicon sheet were much lower than those of the Flat GF and conventional film. The proliferation of cells in PU GF and Flat GF were suppressed compared with control, though increased with time. The anti-adhesive scores of the PU GF after one time and re-attachment were significantly higher than that of non-covered control, although there was no significant difference between that of the conventional film and control. Our findings suggest that PU GF improve handling properties of laparoscopic surgery as it has excellent physical strength, ductility, and adherence to tissue, and low adherence to trocar. In addition, the punctate film may be more useful with the re-attachability without tearing and to retained sufficient anti-adhesion effect. [ABSTRACT FROM AUTHOR]

Published
2025
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2. NF-κB Decoy Oligodeoxynucleotide-Loaded Poly Lactic-co-glycolic Acid Nanospheres Facilitate Socket Healing in Orthodontic Tooth Movement

Author

Huang, Albert chun-shuo, primary, Ishida, Yuji, additional, Hatano-sato, Kasumi, additional, Oishi, Shuji, additional, Hosomichi, Jun, additional, Usumi-fujita, Risa, additional, Yamaguchi, Hiroyuki, additional, Tsujimoto, Hiroyuki, additional, Sasai, Aiko, additional, Ochi, Ayaka, additional, and Ono, Takashi, additional

Published
2024
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7. NF-κB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption

Author

Huang, Albert chun-shuo, primary, Ishida, Yuji, additional, Li, Kai, additional, Rintanalert, Duantawan, additional, Hatano-sato, Kasumi, additional, Oishi, Shuji, additional, Hosomichi, Jun, additional, Usumi-fujita, Risa, additional, Yamaguchi, Hiroyuki, additional, Tsujimoto, Hiroyuki, additional, Sasai, Aiko, additional, Ochi, Ayaka, additional, Watanabe, Hajime, additional, and Ono, Takashi, additional

Published
2023
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11. List of Contributors

Author

Abe, Hiroya, primary, Adschiri, Tadafumi, additional, Aida, Tsutomu, additional, Akatsu, Takashi, additional, Akedo, Jun, additional, Ando, Masanori, additional, Ando, Yoshinori, additional, Anzai, Hiroyuki, additional, Aoki, Nobuaki, additional, Awano, Masanobu, additional, Azushima, Akira, additional, Baba, Tetsuya, additional, Chen, Weiwu, additional, Ehara, Kensei, additional, Emi, Hitoshi, additional, Fudouzi, Hiroshi, additional, Fuji, Masayoshi, additional, Fujii, Hidetoshi, additional, Fukui, Hiroshi, additional, Fukui, Takehisa, additional, Fukumori, Yoshinobu, additional, Goda, Hideki, additional, Gotoh, Kuniaki, additional, Hakuta, Yukiya, additional, Hara, Kaori, additional, Hayashi, Akitoshi, additional, Hayashi, Kazuyuki, additional, Higashitani, Ko, additional, Hirao, Kazuyuki, additional, Hojo, Daisuke, additional, Hosokawa, Kouhei, additional, Hosokawa, Masuo, additional, Hotta, Yuji, additional, Ichikawa, Hideki, additional, Ida, Takashi, additional, Ihara, Manabu, additional, Iijima, Motoyuki, additional, Imai, Yusuke, additional, Inagaki, Shinji, additional, Inoue, Mitsuteru, additional, Iritani, Eiji, additional, Iriyama, Yasutoshi, additional, Ishida, Naoyuki, additional, Ishii, Toshihiro, additional, Isu, Norifumi, additional, Iwata, Mikimasa, additional, Jinnai, Hiroshi, additional, Jiu, Jinting, additional, Kaga, Norihiko, additional, Kajikawa, Kotaro, additional, Kakui, Toshio, additional, Kamiya, Hidehiro, additional, Kaneko, Kenji, additional, Kanie, Kiyoshi, additional, Kano, Junya, additional, Kasai, Hitoshi, additional, Kasuga, Tomoko, additional, Katamoto, Tsutomu, additional, Katsura, Shinji, additional, Kawahara, Masayoshi, additional, Kawashima, Yoshiaki, additional, Kinemuchi, Yoshiaki, additional, Kirihara, Soshu, additional, Koshimizu, Masanori, additional, Kondo, Akihiko, additional, Kondo, Akira, additional, Kondou, Katsuyoshi, additional, Kozawa, Takahiro, additional, Kurihara, Kazue, additional, Kuroda, Shun'ichi, additional, Kurumada, Ken-ichi, additional, Kuwahara, Hiroaki, additional, Li, Chunliang, additional, Makino, Hisao, additional, Maruo, Shoji, additional, Masuda, Hiroaki, additional, Masuda, Yoshitake, additional, Matsuda, Motohide, additional, Matsusaka, Shuji, additional, Matsuyama, Tatsushi, additional, Mezaki, Reiji, additional, Mikayama, Takeshi, additional, Miyahara, Minoru, additional, Miyajima, Kiyotomi, additional, Miyamoto, Yoshinari, additional, Miyayama, Masaru, additional, Miyazaki, Hideki T., additional, Mori, Hidetoshi, additional, Morimoto, Tsutomu, additional, Morita, Kenta, additional, Munakata, Hirokazu, additional, Muto, Hiroyuki, additional, Munir, Muhammad M., additional, Muramatsu, Atsushi, additional, Murase, Norio, additional, Myojo, Toshihiko, additional, Naito, Makio, additional, Nakajima, Noriyuki, additional, Nakamoto, Masami, additional, Nakamura, Masaharu, additional, Nakamura, Keitaro, additional, Nakanishi, Hachiro, additional, Namiki, Norikazu, additional, Nishimura, Yuya, additional, Noda, Naoki, additional, Nogi, Kiyoshi, additional, Noguchi, Yuji, additional, Noma, Junichi, additional, Nomura, Toshiyuki, additional, Ogi, Takashi, additional, Ogino, Chiaki, additional, Ohara, Satoshi, additional, Ohtomo, Akira, additional, Oikawa, Hidetoshi, additional, Okamoto, Tomoichiro, additional, Okubo, Tatsuya, additional, Okuyama, Kikuo, additional, Osada, Minoru, additional, Otani, Yoshio, additional, Otsubo, Yasufumi, additional, Otsuki, Masashi, additional, Saito, Fumio, additional, Sakaguchi, Shuji, additional, Sakka, Yoshio, additional, Sasabe, Shuji, additional, Sasai, Aiko, additional, Sasaki, Takayoshi, additional, Sasaki, Takafumi, additional, Satoh, Norifusa, additional, Senda, Tetsuya, additional, Seong, Gimyeong, additional, Setsuhara, Yuichi, additional, Shikano, Haruhide, additional, Shimada, Manabu, additional, Suda, Akihiko, additional, Suganuma, Katsuaki, additional, Suzuki, Hisao, additional, Suzuki, Michitaka, additional, Suzuki, Takahiro, additional, Takada, Takahiro, additional, Takahashi, Chisato, additional, Takai, Chika, additional, Takami, Seiichi, additional, Takase, Hirofumi, additional, Takebayashi, Kenji, additional, Takeuchi, Hirofumi, additional, Tatami, Junichi, additional, Tatsumisago, Masahiro, additional, Toda, Kenji, additional, Togashi, Takanari, additional, Tojo, Tetsuro, additional, Tomai, Takaaki, additional, Tsujimoto, Hiroyuki, additional, Tsukada, Takao, additional, Tsukada, Yusuke, additional, Uchikoshi, Tetsuo, additional, Uematsu, Keizo, additional, Ueshima, Minoru, additional, Umetsu, Mitsuo, additional, Usuki, Arimitsu, additional, Wakai, Fumihiro, additional, Wei, Xing, additional, Yamaguchi, Akimasa, additional, Yamaguchi, Yukio, additional, Yamamoto, Hiromitsu, additional, Yamamoto, Kenji, additional, Yamamoto, Kimihisa, additional, Yamamoto, Atsushi, additional, Yashima, Masatomo, additional, Yoko, Akira, additional, Yokoi, Atsushi, additional, Yokoyama, Toyokazu, additional, Yonezawa, Susumu, additional, Yonezawa, Tetsu, additional, and Zhang, Qiwu, additional

Published
2018
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13. NF-κB Decoy ODN-Loaded Poly lactic-co-glycolic Acid Nanospheres Inhibit Alveolar Ridge Resorption

Author

Huang, Albert Chun Shuo, primary, Ishida, Yuji, additional, Li, Kai, additional, Rintanalert, Duantawan, additional, Hatano-sato, Kasumi, additional, Oishi, Shuji, additional, Hosomichi, Jun, additional, Usumi-Fujita, Risa, additional, Yamaguchi, Hiroyuki, additional, Tsujimoto, Hiroyuki, additional, Sasai, Aiko, additional, Ochi, Ayaka, additional, Watanabe, Hajime, additional, and Ono, Takashi, additional

Published
2022
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17. A basic study of the effect of the shielding method with polyglycolic acid fabric and fibrin glue after endoscopic submucosal dissection

Author

Tsujimoto Hiroyuki, Yamanaka Kohki, Miyamoto Hiroe, Horii Tsunehito, Abe Rie, Tanaka Shota, Torii Hiroko, Ozamoto Yuki, Toshitaka Takagi, Takimoto Kengo, Torii Takashi, Konishi Hideyuki, Takamori Hideki, and Hagiwara Akeo

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and study aims: Recently, the shielding method with polyglycolic acid (PGA) fabric and fibrin glue (P-F method) has been reported to prevent serious complications after endoscopic submucosal dissection (ESD). However, the effectiveness and mechanism to prevent complications by this method remain unclear and the corresponding basic research has not been fully conducted. Methods and results: We examined the effectiveness and mechanism of the P-F method, using a surgical ESD model of canine stomach and in vitro experiments. In the model experiment treated by P-F method or no treatment (control), ulcer perforation or penetration occurred only in the control group, but not in the P-F group. Microscopically, the P-F group showed less damages of the ulcer lesion than that of the control group, showing thicker granulation tissues including PGA fibers on the third day and excellent mucosal regeneration on the fourteenth day. In vitro culture experiments showed that fibroblasts proliferated at a significantly higher rate on PGA than on fibrin or a complex thereof. However, under hydrochloric acid treatment, fibroblasts were protected by fibrin, followed by the complex of both, and PGA. Conclusion: The P-F method exhibited a protective effect against gastric juice by fibrin glue to reduce tissue damages and a scaffold function of PGA fabric to induce better granulation formation at the earlier phase, resulting in excellent long-term tissue repair, on ulcer lesion following ESD, although the results were based on basic experiments.

Published
2016
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24. Formulation of Nanoparticle-Eluting Stents by a Cationic Electrodeposition Coating Technology: Efficient Nano-Drug Delivery via Bioabsorbable Polymeric Nanoparticle-Eluting Stents in Porcine Coronary Arteries

Author

Nakano, Kaku, Egashira, Kensuke, Masuda, Seigo, Funakoshi, Kouta, Zhao, Gang, Kimura, Satoshi, Matoba, Tetsuya, Sueishi, Katsuo, Endo, Yasuhisa, Kawashima, Yoshiaki, Hara, Kaori, Tsujimoto, Hiroyuki, Tominaga, Ryuji, and Sunagawa, Kenji

Published
2009
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25. Risk factors for postoperative bleeding and early death in percutaneous endoscopic gastrostomy: A multicenter retrospective study

Author

Ota, Kazuhiro, primary, Takeuchi, Toshihisa, additional, Masuda, Daisuke, additional, Sanomura, Makoto, additional, Kojima, Keishi, additional, Nakanishi, Yoshihiko, additional, Hoshimoto, Masahiro, additional, Higashino, Takeshi, additional, Imoto, Akira, additional, Okada, Toshihiko, additional, Nouda, Sadaharu, additional, Miyazaki, Hirota, additional, Ozaki, Haruhiko, additional, Fukuda, Kirie Hashimoto, additional, Kuramoto, Takanori, additional, Sugawara, Noriaki, additional, Onishi, Toshikazu, additional, Takahashi, Yoshiaki, additional, Tsujimoto, Hiroyuki, additional, Yokoya, Yuta, additional, Kawabata, Kazumi, additional, Nishida, Shinya, additional, Hakoda, Akitoshi, additional, Iwatsubo, Taro, additional, Kawaguchi, Shimpei, additional, Kojima, Yuichi, additional, and Higuchi, Kazuhide, additional

Published
2021
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26. Effects of Fiber Diameter and Spacing Size of an Artificial Scaffold on the In Vivo Cellular Response and Tissue Remodeling

Author

Horii, Tsunehito, primary, Tsujimoto, Hiroyuki, additional, Hagiwara, Akeo, additional, Isogai, Noritaka, additional, Sueyoshi, Yu, additional, Oe, Yasumitsu, additional, Kageyama, Susumu, additional, Yoshida, Tetsuya, additional, Kobayashi, Kenichi, additional, Minato, Hiroshi, additional, Ueda, Joe, additional, Ichikawa, Hiroshi, additional, and Kawauchi, Akihiro, additional

Published
2021
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29. List of Contributors

Author

Abe, Hiroya, primary, Adschiri, Tadafumi, additional, Akatsu, Takashi, additional, Akedo, Jun, additional, Ando, Masanori, additional, Ando, Yoshinori, additional, Anzai, Hiroyuki, additional, Awano, Masanobu, additional, Azushima, Akira, additional, Baba, Tetsuya, additional, Chen, Weiwu, additional, Ehara, Kensei, additional, Emi, Hitoshi, additional, Fudouzi, Hiroshi, additional, Fuji, Masayoshi, additional, Fujii, Hidetoshi, additional, Fukui, Hiroshi, additional, Fukui, Takehisa, additional, Fukumori, Yoshinobu, additional, Goda, Hideki, additional, Gotoh, Kuniaki, additional, Hakuta, Yukiya, additional, Hara, Kaori, additional, Hayashi, Kazuyuki, additional, Higashitani, Ko, additional, Hirao, Kazuyuki, additional, Hosokawa, Masuo, additional, Hotta, Yuji, additional, Ichikawa, Hideki, additional, Ida, Takashi, additional, Ihara, Manabu, additional, Inagaki, Shinji, additional, Inoue, Mitsuteru, additional, Iritani, Eiji, additional, Ishida, Naoyuki, additional, Isu, Norifumi, additional, Iwata, Mikimasa, additional, Jinnai, Hiroshi, additional, Kaga, Norihiko, additional, Kajikawa, Kotaro, additional, Kakui, Toshio, additional, Kamiya, Hidehiro, additional, Kaneko, Kenji, additional, Kanie, Kiyoshi, additional, Kano, Junya, additional, Kasai, Hitoshi, additional, Kasuga, Tomoko, additional, Katamoto, Tsutomu, additional, Katsura, Shinji, additional, Kawahara, Masayoshi, additional, Kawashima, Yoshiaki, additional, Kinemuchi, Yoshiaki, additional, Kirihara, Soshu, additional, Kondo, Akira, additional, Kondoh, Akihiko, additional, Kondou, Katsuyoshi, additional, Kousaka, Yasuo, additional, Kurihara, Kazue, additional, Kuroda, Shun’ichi, additional, Kurumada, Ken-ichi, additional, Kuwahara, Hiroaki, additional, Li, Chunliang, additional, Makino, Hisao, additional, Masuda, Hiroaki, additional, Masuda, Yoshitake, additional, Matsuda, Motohide, additional, Matsusaka, Shuji, additional, Matsuyama, Tatsushi, additional, Mezaki, Reiji, additional, Mikayama, Takeshi, additional, Miyahara, Minoru, additional, Miyajima, Kiyotomi, additional, Miyamoto, Yoshinari, additional, Miyayama, Masaru, additional, Miyazaki, Hideki T., additional, Mori, Hidetoshi, additional, Morimoto, Tsutomu, additional, Munakata, Hirokazu, additional, Miftahul Munir, Muhammad, additional, Muramatsu, Atsushi, additional, Murase, Norio, additional, Myojo, Toshihiko, additional, Naito, Makio, additional, Nakajima, Noriyuki, additional, Nakamoto, Masami, additional, Nakamura, Masaharu, additional, Nakamura, Keitaro, additional, Nakanishi, Hachiro, additional, Namiki, Norikazu, additional, Noda, Naoki, additional, Nogi, Kiyoshi, additional, Noguchi, Yuji, additional, Nomura, Toshiyuki, additional, Ogi, Takashi, additional, Ohara, Satoshi, additional, Ohtomo, Akira, additional, Oikawa, Hidetoshi, additional, Okamoto, Tomoichiro, additional, Okubo, Tatsuya, additional, Okuyama, Kikuo, additional, Osada, Minoru, additional, Otani, Yoshio, additional, Otsubo, Yasufumi, additional, Otsuki, Masashi, additional, Saito, Fumio, additional, Sakaguchi, Shuji, additional, Sakka, Yoshio, additional, Sasabe, Shuji, additional, Sasaki, Takayoshi, additional, Sasaki, Takafumi, additional, Satoh, Norifusa, additional, Senda, Tetsuya, additional, Setsuhara, Yuichi, additional, Shikano, Haruhide, additional, Shimada, Manabu, additional, Suda, Akihiko, additional, Suzuki, Hisao, additional, Suzuki, Michitaka, additional, Takada, Takahiro, additional, Takai, Chika, additional, Takami, Seiichi, additional, Takase, Hirofumi, additional, Takebayashi, Kenji, additional, Takeuchi, Hirofumi, additional, Tatami, Junichi, additional, Toda, Kenji, additional, Tojo, Tetsuro, additional, Tsujimoto, Hiroyuki, additional, Uchikoshi, Tetsuo, additional, Uematsu, Keizo, additional, Umetsu, Mitsuo, additional, Usuki, Arimitsu, additional, Wakai, Fumihiro, additional, Yamaguchi, Akimasa, additional, Yamaguchi, Yukio, additional, Yamamoto, Hiromitsu, additional, Yamamoto, Kenji, additional, Yamamoto, Kimihisa, additional, Yamamoto, Atsushi, additional, Yashima, Masatomo, additional, Yokoyama, Toyokazu, additional, Yonezawa, Susumu, additional, and Zhang, Qiwu, additional

Published
2012
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32. List of Contributors

Author

Abe, Hiroya, primary, Adschiri, Tadafumi, additional, Akatsu, Takashi, additional, Akedo, Jun, additional, Ando, Masanori, additional, Ando, Yoshinori, additional, Awano, Masanobu, additional, Azushima, Akira, additional, Baba, Tetsuya, additional, Ehara, Kensei, additional, Emi, Hitoshi, additional, Fudouzi, Hiroshi, additional, Fukui, Hiroshi, additional, Fukui, Takehisa, additional, Fukumori, Yoshinobu, additional, Fuji, Masayoshi, additional, Fujii, Hidetoshi, additional, Goda, Hideki, additional, Gotoh, Kuniaki, additional, Hakuta, Yukiya, additional, Hara, Kaori, additional, Hayashi, Kazuyuki, additional, Higashitani, Ko, additional, Hirao, Kazuyuki, additional, Hosokawa, Masuo, additional, Hotta, Yuji, additional, Ichikawa, Hideki, additional, Ida, Takashi, additional, Ihara, Manabu, additional, Inagaki, Shinji, additional, Inoue, Mitsuteru, additional, Iritani, Eiji, additional, Ishida, Naoyuki, additional, Iwata, Mikimasa, additional, Kajikawa, Kotaro, additional, Kakui, Toshio, additional, Kamiya, Hidehiro, additional, Kaneko, Kenji, additional, Kanie, Kiyoshi, additional, Kasai, Hitoshi, additional, Kasuga, Tomoko, additional, Katamoto, Tsutomu, additional, Katsura, Shinji, additional, Kawahara, Masayoshi, additional, Kinemuchi, Yoshiaki, additional, Kirihara, Soshu, additional, Kondoh, Akihiko, additional, Kondou, Katsuyoshi, additional, Kousaka, Yasuo, additional, Kurihara, Kazue, additional, Kuroda, Shun'ichi, additional, Kurumada, Ken-ichi, additional, Li, Chunliang, additional, Makino, Hisao, additional, Masuda, Hiroaki, additional, Masuda, Yoshitake, additional, Matsuda, Motohide, additional, Matsuyama, Tatsushi, additional, Matsusaka, Shuji, additional, Mezaki, Reiji, additional, Mikayama, Takeshi, additional, Miyajima, Kiyotomi, additional, Miyahara, Minoru, additional, Miyamoto, Yoshinari, additional, Miyayama, Masaru, additional, Miyazaki, Hideki T., additional, Mori, Hidetoshi, additional, Morimoto, Tsutomu, additional, Muramatsu, Atsushi, additional, Murase, Norio, additional, Myojo, Toshihiko, additional, Naito, Makio, additional, Nakajima, Noriyuki, additional, Nakanishi, Hachiro, additional, Nakamoto, Masami, additional, Namiki, Norikazu, additional, Nogi, Kiyoshi, additional, Noguchi, Yuji, additional, Nomura, Toshiyuki, additional, Ohara, Satoshi, additional, Ohtomo, Akira, additional, Oikawa, Hidetoshi, additional, Okamoto, Tomoichiro, additional, Okubo, Tatsuya, additional, Okuyama, Kikuo, additional, Otani, Yoshio, additional, Otsubo, Yasufumi, additional, Saito, Fumio, additional, Sakaguchi, Shuji, additional, Sakka, Yoshio, additional, Sasaki, Takafumi, additional, Satoh, Norifusa, additional, Shikano, Haruhide, additional, Shimada, Manabu, additional, Senda, Tetsuya, additional, Setsuhara, Yuichi, additional, Suda, Akihiko, additional, Suzuki, Hisao, additional, Suzuki, Michitaka, additional, Takada, Takahiro, additional, Takami, Seiichi, additional, Takase, Hirofumi, additional, Takeuchi, Hirofumi, additional, Tatami, Junichi, additional, Toda, Kenji, additional, Tsujimoto, Hiroyuki, additional, Uchikoshi, Tetsuo, additional, Uematsu, Keizo, additional, Umetsu, Mitsuo, additional, Usuki, Arimitsu, additional, Wakai, Fumihiro, additional, Yamaguchi, Akimasa, additional, Yamaguchi, Yukio, additional, Yamamoto, Atsushi, additional, Yamamoto, Hiromitsu, additional, Yamamoto, Kenji, additional, Yamamoto, Kimihisa, additional, Yashima, Masatomo, additional, Yokoyama, Toyokazu, additional, and Yonezawa, Susumu, additional

Published
2008
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33. The usefulness of re-attachability of anti-adhesive cross-linked gelatin film and the required physical and biological properties

Author

Horii, Tsunehito, primary, Tsujimoto, Hiroyuki, additional, Kageyama, Susumu, additional, Yoshida, Tetsuya, additional, Kobayashi, Kenichi, additional, Takamori, Hideki, additional, Minato, Hiroshi, additional, Ueda, Jo, additional, Hagiwara, Akeo, additional, Ichikawa, Hiroshi, additional, and Kawauchi, Akihiro, additional

Published
2020
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40. Risk factors for postoperative bleeding and early death in percutaneous endoscopic gastrostomy: A multicenter retrospective study.

Author

Ota, Kazuhiro, Takeuchi, Toshihisa, Masuda, Daisuke, Sanomura, Makoto, Kojima, Keishi, Nakanishi, Yoshihiko, Hoshimoto, Masahiro, Higashino, Takeshi, Imoto, Akira, Okada, Toshihiko, Nouda, Sadaharu, Miyazaki, Hirota, Ozaki, Haruhiko, Fukuda, Kirie Hashimoto, Kuramoto, Takanori, Sugawara, Noriaki, Onishi, Toshikazu, Takahashi, Yoshiaki, Tsujimoto, Hiroyuki, and Yokoya, Yuta

Subjects
PERCUTANEOUS endoscopic gastrostomy, EARLY death, PREOPERATIVE risk factors, BODY mass index, HEMORRHAGE, PLATELET count
Abstract

Background and Aim: Comprehensive reports on the risk factors for bleeding and early death after percutaneous endoscopic gastrostomy (PEG) are limited. In this multicenter study, we retrospectively investigated the risk factors for bleeding and early death after PEG. Methods: Patients (n = 1234) who underwent PEG between 2015 and 2020 at Osaka Medical and Pharmaceutical University and its affiliated hospitals (11 institutions in total) were evaluated for postoperative bleeding and early death (within 60 days) after PEG according to patient characteristics, construction method, medical history, medications, preoperative hematological findings, and perioperative adverse events. Multivariate logistic regression was performed to identify independent predictors of bleeding and early death after PEG. Results: The risk factors for bleeding after PEG were PEG tube insertion using the modified introducer method (odds ratio [OR], 4.37; P = 0.0003), low platelet count (OR, 0.99; P = 0.014), antiplatelet therapy (OR, 2.11; P = 0.036), and heparinization (OR, 4.50; P = 0.007). Risk factors for early death were low body mass index (BMI) (OR, 0.89; P = 0.015), low serum albumin levels (OR, 0.50; P = 0.035), and comorbidity of active cancer (OR, 4.03; P < 0.0001). There was no significant association between bleeding and early death after PEG. Conclusions: We identified several risk factors for bleeding and early death after PEG. Risk factors for bleeding were PEG tube insertion using the modified introducer method, low platelet count, antiplatelet therapy, and heparinization. Risk factors for early death were low BMI, low serum albumin levels, and comorbidity of active cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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47. A Novel Bioabsorbable Sheet That Delivers NF-κB Decoy Oligonucleotide Restrains Abdominal Aortic Aneurysm Development in Rats

Author

Akimoto, Shouta, primary, Suzuki, Jun-ichi, additional, Aoyama, Norio, additional, Ikeuchi, Ryota, additional, Watanabe, Hajime, additional, Tsujimoto, Hiroyuki, additional, Wakayama, Kouji, additional, Kumagai, Hidetoshi, additional, Ikeda, Yuichi, additional, Akazawa, Hiroshi, additional, and Komuro, Issei, additional

Published
2018
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48. Periocular injection of candesartan-PLGA microparticles inhibits laser-induced experimental choroidal neovascularization

Author

Okuda,Yoshitaka, Fukumoto,Masanori, Horie,Taeko, Oku,Hidehiro, Takai,Shinji, Nakanishi,Toyofumi, Matsuzaki,Kaori, Tsujimoto,Hiroyuki, Ikeda,Tsunehiko, Okuda,Yoshitaka, Fukumoto,Masanori, Horie,Taeko, Oku,Hidehiro, Takai,Shinji, Nakanishi,Toyofumi, Matsuzaki,Kaori, Tsujimoto,Hiroyuki, and Ikeda,Tsunehiko

Abstract

Yoshitaka Okuda,1 Masanori Fukumoto,1 Taeko Horie,1 Hidehiro Oku,1 Shinji Takai,2 Toyofumi Nakanishi,3 Kaori Matsuzaki,4 Hiroyuki Tsujimoto,4 Tsunehiko Ikeda1 1Department of Ophthalmology, Osaka Medical College, Osaka, Japan; 2Department of Innovative Medicine, Graduate School of Medicine, Osaka Medical College, Osaka, Japan; 3Department of Clinical and Laboratory Medicine, Osaka Medical College, Osaka, Japan; 4Research and Development Division, Hosokawa Micron Corporation, Osaka, Japan Purpose: Microparticle technology enables local administration of medication. The purpose of this study was to examine the inhibitory effect of locally administered candesartan (CAN)-encapsulated microparticles on experimental choroidal neovascularization (CNV). Methods: Laser photocoagulation was used to induce CNV in Brown Norway rats. The rats were pretreated with subconjunctival injections of CAN (5.0 mg/eye) or phosphate buffer saline for 3 days before photocoagulation. The volume of CNV was evaluated 7 days after laser injury using the lectin staining technique. The infiltration of macrophages within the CNV lesion was determined using immunofluorescent staining with an anti-CD68 antibody. mRNA levels of MCP-1, IL1-β and VEGF in the retinal pigment epithelium/choroid complex were determined using quantitative PCR (q-PCR). Results: CNV volume was significantly suppressed by the treatment with CAN compared with that in vehicle-treated eyes (P<0.05, two-tailed Student’s t-test). Subconjunctival injections of CAN decreased the numbers of CD68+ cells in the CNV lesion. The increased mRNA levels of MCP-1, IL1-β, and VEGF induced by photocoagulation was significantly suppressed following the local administration of CAN (P<0.05, two-tailed Student’s t-test). Conclusion: Local administration of CAN inhibited experimentally induced CNV possibly through anti-inflammatory effects. Keywords: age-related macular degeneration, choro

Published
2018

49. A basic study of the effect of the shielding method with polyglycolic acid fabric and fibrin glue after endoscopic submucosal dissection

Author

Abe Rie, Ozamoto Yuki, Toshitaka Takagi, Takimoto Kengo, Yamanaka Kohki, Torii Hiroko, Takamori Hideki, Tanaka Shota, Konishi Hideyuki, Hagiwara Akeo, Miyamoto Hiroe, Horii Tsunehito, Torii Takashi, and Tsujimoto Hiroyuki

Subjects
medicine.medical_specialty, Original article, biology, business.industry, Stomach, Ulcer lesion, Endoscopic submucosal dissection, Tissue repair, Fibrin, Surgery, 03 medical and health sciences, Granulation, 0302 clinical medicine, medicine.anatomical_structure, Basic research, 030220 oncology & carcinogenesis, biology.protein, Medicine, lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology, Pharmacology (medical), lcsh:RC799-869, business, Fibrin glue
Abstract

Background and study aims: Recently, the shielding method with polyglycolic acid (PGA) fabric and fibrin glue (P-F method) has been reported to prevent serious complications after endoscopic submucosal dissection (ESD). However, the effectiveness and mechanism to prevent complications by this method remain unclear and the corresponding basic research has not been fully conducted. Methods and results: We examined the effectiveness and mechanism of the P-F method, using a surgical ESD model of canine stomach and in vitro experiments. In the model experiment treated by P-F method or no treatment (control), ulcer perforation or penetration occurred only in the control group, but not in the P-F group. Microscopically, the P-F group showed less damages of the ulcer lesion than that of the control group, showing thicker granulation tissues including PGA fibers on the third day and excellent mucosal regeneration on the fourteenth day. In vitro culture experiments showed that fibroblasts proliferated at a significantly higher rate on PGA than on fibrin or a complex thereof. However, under hydrochloric acid treatment, fibroblasts were protected by fibrin, followed by the complex of both, and PGA. Conclusion: The P-F method exhibited a protective effect against gastric juice by fibrin glue to reduce tissue damages and a scaffold function of PGA fabric to induce better granulation formation at the earlier phase, resulting in excellent long-term tissue repair, on ulcer lesion following ESD, although the results were based on basic experiments.

Published
2016

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