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487 results on '"Tsujikawa K"'

1. Lipopolysaccharide from gut microbiota promotes prostate cancer growth through histamine H1 receptor signaling

Author

Fujita, K., primary, Matsushita, M., additional, Motooka, D., additional, Hase, H., additional, Banno, E., additional, De Velasco, M.A., additional, Kato, T., additional, Hatano, K., additional, Kawashima, A., additional, Uemura, M., additional, Nakamura, S., additional, Tsujikawa, K., additional, Morii, E., additional, Uemura, H., additional, and Nonomura, N., additional

Published
2022
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6. Si-based Mach-Zehnder wavelength/mode multi/demultiplexer for a WDM/MDM transmission system

Author

Ohta, S., Fujisawa, T., Makino, S., Sakamoto, T., Matsui, T., Tsujikawa, K., Nakajima, K., Saitoh, K., Ohta, S., Fujisawa, T., Makino, S., Sakamoto, T., Matsui, T., Tsujikawa, K., Nakajima, K., and Saitoh, K.

Abstract

We propose and experimentally demonstrate a low-loss and low-crosstalk MachZehnder mode/wavelength multi/demultiplexer for WDM/MDM transmission based on a Siphotonics platform. A broadband 3-dB mode divider, which is also newly devised here, makes it possible to compose a Mach-Zehnder filter for "mode" and "wavelength" simultaneously. Transmission characteristics of fabricated 3-dB mode dividers are in excellent agreement with theoretical results. Mach-Zehnder filters using the 3-dB mode divider with a free spectral range (FSR) of 20 and 1 nm are also fabricated and the modal crosstalk is less than -24 dB in the 40-nm wavelength range for the MZ filter with an FSR of 20 nm. The tuning of the peak wavelength position by the TiN heater is also demonstrated. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Published
2018

19. Roles of Integrins and CD44 on the Adhesion and Migration of Fetal Liver Cells to the Fetal Thymus

Author

Naoto Kawakami, Nishizawa, F., Sakane, N., Iwao, M., Tsujikawa, K., Ikawa, M., Okabe, M., and Yamamoto, H.

Subjects
Male, Integrins, Integrin alpha4, Green Fluorescent Proteins, Immunology, Cell Differentiation, Mice, Transgenic, Thymus Gland, Mice, Inbred C57BL, Luminescent Proteins, Mice, Fetus, Hyaluronan Receptors, Liver, Antigens, CD, Cell Movement, Cell Adhesion, Animals, Immunology and Allergy, Hyaluronic Acid, Cell Adhesion Molecules
Abstract

Adhesion and migration of mouse fetal liver (FL) cells to the thymus were investigated using cells from green fluorescent protein transgenic (GFP+) mice. FL cells from GFP+ embryos at 12 gestational days (E12) of mice were incubated with 2′-deoxyguanosine-treated fetal thymus lobe (from E14) by thymic repopulation (hanging drop) culture methods. GFP+ cells were observed in the thymus lobe at the end of the repopulation culture period. A large part of the infiltrated cells expressed CD44 until day 2 of culture on a permeable membrane, then lost the expression. CD25 expression was observed from day 1 to day 4. Around day 8, GFP+ cells became both CD4+ and CD8+. The results support the early observation of the sequential expression of CD44, CD25, and CD4/8 during the early stages of thymocyte development. When anti-CD44 mAb was added at the beginning of the repopulation culture period, GFP+ FL cells adhered to the surface of the thymus lobe but did not migrate into the thymus. Pretreatment of the thymus with hyaluronidase or hyaluronate produced results similar to the results of anti-CD44 treatment. On the other hand, the addition of anti-integrin α4 mAb inhibited adhesion to the thymus, and almost no GFP+ cells were seen on the surface of the thymus lobe. The data suggest that integrin α4 and CD44 play different roles, i.e., integrin α4 is required for the adhesion of FL cells to the thymus lobe and CD44 is required for the migration of the cells into the thymus.

Published
1999

24. 1.01-Pb/s (12 SDM/222 WDM/456 Gb/s) Crosstalk-managed Transmission with 91.4-b/s/Hz Aggregate Spectral Efficiency

Author

Takara, H., Sano, A., Kobayashi, T., Kubota, H., Kawakami, H., Matsuura, A., Miyamoto, Y., Abe, Y., Ono, H., Shikama, K., Goto, Y., Tsujikawa, K., Sasaki, Y., Ishida, I., Takenaga, K., Matsuo, K., Saitoh, K., Koshiba, M., Morioka, Toshio, Takara, H., Sano, A., Kobayashi, T., Kubota, H., Kawakami, H., Matsuura, A., Miyamoto, Y., Abe, Y., Ono, H., Shikama, K., Goto, Y., Tsujikawa, K., Sasaki, Y., Ishida, I., Takenaga, K., Matsuo, K., Saitoh, K., Koshiba, M., and Morioka, Toshio

Abstract

We demonstrate 1.01-Pb/s transmission over 52 km with the highest aggregate spectral efficiency of 91.4 b/s/Hz by using low-crosstalk one-ring-structured 12-core fiber. Our multi-core fiber and compact fan-in/fan-out devices are designed to support high-order modulation formats up to 32-QAM in SDM transmission.

Published
2012

25. Interaction of merosin (laminin 2) with very late activation antigen-6 is necessary for the survival of CD4+ CD8+ immature thymocytes

Author

Iwao, M, Fukada, S, Harada, T, Tsujikawa, K, Yagita, H, Hiramine, C, Miyagoe, Y, Takeda, S, and Yamamoto, H

Subjects
CD4-Positive T-Lymphocytes, Integrins, Mice, Inbred BALB C, Integrin alpha6beta1, Cell Survival, T-Lymphocytes, Antibodies, Monoclonal, Apoptosis, Original Articles, Thymus Gland, CD8-Positive T-Lymphocytes, Muscular Dystrophy, Animal, Epithelium, Mice, Mutant Strains, Mice, Animals, Laminin, Cells, Cultured, Gene Deletion
Abstract

The laminin alpha2-chain is a component of merosin, a member of the laminin family molecules, which is mainly expressed in the basement membranes of striated muscle. It is known that laminin alpha2 gene (lama2) null mutant mice (dy3k/dy3k) exhibit congenital muscular dystrophy (CMD). Because the laminin alpha2-chain is also expressed in the thymus, the role of merosin in the thymus was examined. In association with the onset of muscular dystrophy, CD4+ CD8+ double-positive (DP) thymocytes disappear by apoptotic cell death, while CD4+ CD8- or CD4- CD8+ thymocytes remain. In order to study the mechanisms leading to the selective death of DP cells in the absence of merosin, the role of the interaction between very late activation antigen-6 (VLA-6), a candidate merosin ligand in the thymus, and merosin was examined. The in vitro survival of thymocytes from normal mice was maintained by the addition of either anti-VLA-6 monoclonal antibodies (mAbs) or merosin. Furthermore, when the normal thymocytes were cultured on thymic epithelial cell lines, viable DP cell recoveries on wild-type epithelial cells were better than on cells from null mutant mice. The results suggest that DP cells are more sensitive to an uncharacterized apoptotic death signal, and that survival is supported by the interaction between VLA-6 and merosin.

Published
2000

31. Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells

Author

Koike, K., primary, Ueda, Y., additional, Hase, H., additional, Kitae, K., additional, Fusamae, Y., additional, Masai, S., additional, Inagaki, T., additional, Saigo, Y., additional, Hirasawa, S., additional, Nakajima, K., additional, Ohshio, I., additional, Makino, Y., additional, Konishi, N., additional, Yamamoto, H., additional, and Tsujikawa, K., additional

Published
2012
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33. 1.01-Pb/s (12 SDM/222 WDM/456 Gb/s) Crosstalk-managed Transmission with 91.4-b/s/Hz Aggregate Spectral Efficiency

Author

Takara, H., primary, Sano, A., additional, Kobayashi, T., additional, Kubota, H., additional, Kawakami, H., additional, Matsuura, A., additional, Miyamoto, Y., additional, Abe, Y., additional, Ono, H., additional, Shikama, K., additional, Goto, Y., additional, Tsujikawa, K., additional, Sasaki, Y., additional, Ishida, I., additional, Takenaga, K., additional, Matsuo, S., additional, Saitoh, K., additional, Koshiba, M., additional, and Morioka, T., additional

Published
2012
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41. The novel CGRP receptor antagonist BIBN4096 BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus.

Author

Glowka, T. R., Steinebach, A., Stein, K., Schwandt, T., Lysson, M., Holzmann, B., Tsujikawa, K., Jonge, W. J., Kalff, J. C., and Wehner, S.

Subjects
CALCITONIN gene-related peptide, BOWEL obstructions, INFLAMMATORY bowel diseases, ABDOMINAL surgery, MACROPHAGES
Abstract

Background Abdominal surgery results in neuronal mediator release and subsequent acute intestinal hypomotility. This phase is followed by a longer lasting inflammatory phase resulting in postoperative ileus ( POI). Calcitonin gene-related peptide ( CGRP) has been shown to induce motility disturbances and in addition may be a candidate mediator to elicit neurogenic inflammation. We hypothesized that CGRP contributes to intestinal inflammation and POI. Methods The effect of CGRP in POI was tested in mice treated with the highly specific CGRP receptor antagonist BIBN4096 BS and in CGRP receptor-deficient ( RAMP-1−/−) mice. POI severity was analyzed by cytokine expression, muscular inflammation and gastrointestinal ( GI) transit. Peritoneal and muscularis macrophages and mast cells were analyzed for CGRP receptor expression and functional response to CGRP stimulation. Key Results Intestinal manipulation ( IM) resulted in CGRP release from myenteric nerves, and a concurrent increased interleukin ( IL)-6 and IL-1 β transcription and leukocyte infiltration in the muscularis externa and increased GI transit time. CGRP potentiates IM-induced cytokine transcription within the muscularis externa and peritoneal macrophages. BIBN4096 BS reduced cytokine levels and leukocyte infiltration and normalized GI transit. RAMP1−/− mice showed a significantly reduced leukocyte influx. CGRP receptor was expressed in muscularis and peritoneal macrophages but not mast cells. CGRP mediated macrophage activation but failed to induce mast cell degranulation and cytokine expression. Conclusions & Inferences CGRP is immediately released during abdominal surgery and induces a neurogenic inflammation via activation of abdominal macrophages. BIBN4096 BS prevented IM-induced inflammation and restored GI motility. These findings suggest that CGRP receptor antagonism could be instrumental in the prevention of POI. [ABSTRACT FROM AUTHOR]

Published
2015
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44. Visible to Infrared WDM Transmission over PCF

Author

leda, K., primary, Kurokawa, K., additional, Shimizu, T., additional, Tajima, K., additional, Nakajima, K., additional, Matsui, T., additional, Tsujikawa, K., additional, Shiraki, K., additional, and Sankawa, I., additional

Published
2006
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