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7. Clinical application of hydroxyapatite

Author

Oohashi, H, primary, Oonishi, H, additional, Hench, L, additional, Wilson, J, additional, Kim, S, additional, Tsuji, E, additional, Oomamiuda, K, additional, and Fujita, H, additional

Published
2008
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8. Clinical application of hydroxyapatite

Author

OONISHI, H, primary, OONISHI, H, additional, KIM, S C, additional, HENCH, L L, additional, WILSON, J, additional, TSUJI, E, additional, FUJITA, H, additional, OOHASHI, H, additional, and OOMAMIUDA, K, additional

Published
2008
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9. Contributor contact details

Author

Kokubo, Tadashi, primary, Currey, John, additional, Tanaka, Yumi, additional, Yamashita, Kimihiro, additional, Hayakawa, Satoshi, additional, Tsuru, Kanji, additional, Osaka, Akiyoshi, additional, Swain, Michael V., additional, He, Li-Hong, additional, Clarke, Ian C., additional, Gustafson, Allen, additional, Knabe, Christine, additional, Ducheyne, Paul, additional, Takadama, Hiroaki, additional, Kokubo, Tadashi, additional, Nakamura, Takashi, additional, Takemoto, Mitsuru, additional, de Bruijn, J.D., additional, Shankar, K., additional, Yuan, H., additional, Habibovic, P., additional, Ben-Nissan, Besim, additional, Choi, Andy H., additional, Cordingley, Rebecca, additional, Chevalier, Jérôme, additional, Gremillard, Laurent, additional, Jones, Julian R., additional, Ricci, John L., additional, Weiner, Michael J., additional, Mamidwar, Sachin, additional, Alexander, Harold, additional, Rey, Christian, additional, Combes, Christèle, additional, Drouet, Christophe, additional, Somrani, Sayda, additional, LeGeros, Racquel Zapanta, additional, LeGeros, John P., additional, Daculsi, Guy, additional, Thian, Eng San, additional, Best, Serena M., additional, Ishikawa, Kunio, additional, Leeuwenburgh, Sander C.G., additional, Wolke, Joop G.C., additional, Jansen, John A., additional, de Groot, Klaas, additional, Matsushita, Tomiharu, additional, Ohtsuki, Chikara, additional, Van Thompson, P., additional, Dianne Rekow, E., additional, Höland, W., additional, Rheinberger, V., additional, Ylänen, Heimo O., additional, Yamamuro, Takao, additional, Oonishi, H., additional, Kim, S.C., additional, Hench, L.L., additional, Wilson, J., additional, Tsuji, E., additional, Fujita, H., additional, Oohashi, H., additional, Oomamiuda, K., additional, Sedel, Laurent, additional, Masuda, S., additional, Kyomoto, M., additional, Ueno, M., additional, and Ohgushi, Hajime, additional

Published
2008
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18. Bone Growth into Spaces Between 45S5 Bioglass Granules

Author

Oonishi, H., primary, Kushitani, S., additional, Yasukawa, E., additional, Kawakami, H., additional, Nakata, A., additional, Koh, S., additional, Hench, L.L., additional, Wilson, J., additional, Tsuji, E., additional, and Sugihara, T., additional

Published
1994
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20. Highly increased capacitance and thermal stability of anodic oxide films on oxygen-incorporated Zr-Ti alloy

Author

1000050208568, Habazaki, H., Kobayashi, K., Tsuji, E., Zhu, C., Aoki, Y., Nagata, S., 1000050208568, Habazaki, H., Kobayashi, K., Tsuji, E., Zhu, C., Aoki, Y., and Nagata, S.

Abstract

Heat treatment of Zr-24 at% Ti alloy with barrier-type dielectric anodic oxide films was conducted at 473 K in air to examine the thermal stability of the dielectric oxide films for possible electrolytic capacitor application. The anodic oxide film was formed by anodizing of the alloy at 50 V for 30 min in 0.1 mol dm(-3) ammonium pentaborate electrolyte. The anodic oxide film of 125 nm thickness was crystalline, containing both monoclinic and tetragonal ZrO2 phase. It was found that marked thickening of the oxide film with generation of cracks occurred during heat treatment at 473 K. Thus, the dielectric loss was largely increased along with the capacitance increase. In contrast, the anodic oxide film formed on the oxygen-incorporated alloy remained uniform, and no significant increase in dielectric loss was observed even after the heat treatment. The capacitance of the anodic film became as high as 4.8 mF m(-2), which was nearly twice that on Ta. The high capacitance was associated with the preferential formation of tetragonal ZrO2 phase in the anodic oxide film on the oxygen-incorporated alloy. Findings indicated that the oxygen-incorporated Zr-Ti alloy is a promising novel material for capacitor application.

Published
2017

21. Tuning of solid state properties of Al-Ta mixed oxides

Author

DI FRANCO, Francesco, SANTAMARIA, Monica, DI QUARTO, Francesco, Zaffora, A, Tsuji, E, Habazaki, H., Di Franco, F, Zaffora, A, Santamaria, M, Di Quarto, F, Tsuji, E, and Habazaki, H

Subjects
Settore ING-IND/23 - Chimica Fisica Applicata, solid state properties, Al-Ta mixed oxides, Photoelectrochemistry, Electrochemical Impedance Spectroscopy
Published
2014

22. Electrochemical fabrication of high k Al-Ta mixed oxides

Author

DI FRANCO, Francesco, SANTAMARIA, Monica, DI QUARTO, Francesco, Zaffora, A, Tsuji, E, Habazaki, H., Di Franco, F, Zaffora, A, Santamaria, M, Di Quarto, F, Tsuji, E, and Habazaki, H

Subjects
Electrochemical fabrication, high k Al-Ta mixed oxides, Photoelectrochemistry, Electrochemical Impedance Spectroscopy, Tuning of solid state properties, Settore ING-IND/23 - Chimica Fisica Applicata
Published
2014

24. Growth and field crystallization of anodic films on Ta–Nb alloys

Author

Komiyama S, Tsuji E, Aoki Y, Habazaki H, Skeldon P, Thompson GE, SANTAMARIA, Monica, DI QUARTO, Francesco, Komiyama S, Tsuji E, Aoki Y, Habazaki H, Santamaria M, Di Quarto F, Skeldon P, and Thompson GE

Subjects
GDOES, Settore ING-IND/23 - Chimica Fisica Applicata, Nb–Ta alloy, Ionic transport, TEM, TAnodic oxide, RBS
Abstract

The growth behavior of amorphous anodic films on Ta–Nb solid solution alloys has been investigated over a wide composition range at a constant current density of 50 Am−2 in 0.1 mol dm−3 ammonium pentaborate electrolyte. The anodic films consist of two layers, comprising a thin outer Nb2O5 layer and an inner layer consisting of units of Ta2O5 and Nb2O5. The outer Nb2O5 layer is formed as a consequence of the faster outward migration of Nb5+ ions, compared with Ta5+ ions, during film growth under the high electric field. Their relative migration rates are independent of the alloy composition. The formation ratio, density, and capacitance of the films show a linear relation to the alloy composition. The susceptibility of the anodic films to field crystallization during anodizing at constant voltage increases with increasing niobium content of the alloy.

Published
2012

25. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

Author

Tominaga, K, primary, Shimamura, T, additional, Kimura, N, additional, Murayama, T, additional, Matsubara, D, additional, Kanauchi, H, additional, Niida, A, additional, Shimizu, S, additional, Nishioka, K, additional, Tsuji, E-i, additional, Yano, M, additional, Sugano, S, additional, Shimono, Y, additional, Ishii, H, additional, Saya, H, additional, Mori, M, additional, Akashi, K, additional, Tada, K-i, additional, Ogawa, T, additional, Tojo, A, additional, Miyano, S, additional, and Gotoh, N, additional

Published
2016
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26. [Untitled]

Author

Oonishi H, Y. Y. Kim, and Tsuji E

Subjects
Materials science, genetic structures, Scanning electron microscope, Metallurgy, Biomedical Engineering, Biophysics, Total hip replacement, Bioengineering, Polyethylene, Steel ball, Total knee, Biomaterials, chemistry.chemical_compound, chemistry, Ball (bearing), High doses, sense organs, Irradiation, Composite material, human activities
Abstract

Polyethylene cups and femoral heads of retrieved total hip prostheses (Charnley 22 mm stainless steel ball, Bioceram 28 mm alumina ball and Muller 32 mm Co-Cr-Mo alloy ball) were observed by the naked-eye and scanning electron microscopy. Cross-linked cups irradiated with gamma radiation in heavy high doses of 100 Mrad were included. On the weight-bearing surface of the cups non-gamma irradiated, carpet-like conspicuous fine fibres, scratches and fine crevices for the 22 mm ball, scale-like with rough and fine crevices for the 28 mm ball, and scale-like structures and many scratches for the 32 mm ball, were observed, mainly. On the whole, the number of crevices for the 32 mm ball was fewer than that for the 22 and 28 mm balls. The weight-bearing areas of the gamma-irradiated cups presented a clearly outlined pattern, irregularly lined with smooth ripples of about 0.1 microm. The scratching, flaking and delamination, characteristic of non-gamma irradiated polyethylene, were not observed at all. These findings indicate that wear is very small for gamma-irradiated polyethylene. For references, the weight-bearing surfaces of retrieved total knee prostheses were compared.

Published
1998

36. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

Author

Tominaga, K, Shimamura, T, Kimura, N, Murayama, T, Matsubara, D, Kanauchi, H, Niida, A, Shimizu, S, Nishioka, K, Tsuji, E-i, Yano, M, Sugano, S, Shimono, Y, Ishii, H, Saya, H, Mori, M, Akashi, K, Tada, K-i, Ogawa, T, Tojo, A, Miyano, S, and Gotoh, N

Abstract

The transcription factor nuclear factor-κB (NF-κB) has important roles for tumorigenesis, but how it regulates cancer stem cells (CSCs) remains largely unclear. We identified insulin-like growth factor 2 (IGF2) is a key target of NF-κB activated by HER2/HER3 signaling to form tumor spheres in breast cancer cells. The IGF2 receptor, IGF1 R, was expressed at high levels in CSC-enriched populations in primary breast cancer cells. Moreover, IGF2-PI3K (IGF2-phosphatidyl inositol 3 kinase) signaling induced expression of a stemness transcription factor, inhibitor of DNA-binding 1 (ID1), and IGF2 itself. ID1 knockdown greatly reduced IGF2 expression, and tumor sphere formation. Finally, treatment with anti-IGF1/2 antibodies blocked tumorigenesis derived from the IGF1RhighCSC-enriched population in a patient-derived xenograft model. Thus, NF-κB may trigger IGF2-ID1-IGF2-positive feedback circuits that allow cancer stem-like cells to appear. Then, they may become addicted to the circuits. As the circuits are the Achilles’ heels of CSCs, it will be critical to break them for eradication of CSCs.

Published
2017
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