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Key Clinical Message: The treatment method of placing a small number of implants in the mandible as a removable implant‐supported overdenture (IOD) enables implant placement and denture stability, even in cases with severe residual ridge resorption. In this case report, a new implant placement technique was performed using a three‐dimensionally (3D)‐printed duplicate denture fabricated by a 3D printer, resulting in the restoration of masticatory function through IOD. [ABSTRACT FROM AUTHOR]

Staphylococcus aureus is a commensal bacterium in humans, but it sometimes causes opportunistic infectious diseases such as suppurative skin disease, pneumonia, and enteritis. Therefore, it is important to determine the prevalence of S. aureus and methicillin‐resistant S. aureus (MRSA) in individuals, especially older adults. In this study, we investigated the prevalence of S. aureus and MRSA in the oral cavity and feces of residents in long‐term care facilities (LTCFs). S. aureus was isolated from the oral cavity of 61/178 (34.3%) participants, including 28 MRSA‐positive participants (15.7%), and from the feces of 35/127 (27.6%) participants, including 16 MRSA‐positive participants (12.6%). S. aureus and MRSA were isolated from both sites in 19/127 individuals (15.0%) and 10/127 individuals (7.9%), respectively. Among 19 participants with S. aureus isolation from both sites, 17 participants showed the same sequence type (ST) type. Then, we analyzed the correlation of S. aureus and MRSA in the oral cavity and rectum with the participant's condition. S. aureus and MRSA positivity in the oral cavity was significantly related to tube feeding, while there was no correlation of rectal S. aureus/MRSA with any factors. Our findings regarding the oral inhabitation of MRSA and its risk factors indicate the importance of considering countermeasures against MRSA infection in LTCFs. [ABSTRACT FROM AUTHOR]

Background: Evaluation of low tongue pressure is used to diagnose oral hypofunction. The pathophysiology of oral hypofunction is hypothesized to be associated with oral dysfunction related to ageing. Depression in older adults is a major problem and is related to handgrip strength, which is related to tongue pressure. We hypothesized that low tongue pressure could indicate depression mood in community‐dwelling older adults. Objectives: This study aimed to measure maximum tongue pressure and compare it to the responses to the Kihon Checklist (KCL), which is used to check mental and physical deterioration of community‐dwelling older adults. Methods: A total of 49 community‐dwelling independent older adults with stable dental condition (23 men, 26 women; median age, 79 years) answered the KCL, which contained questions on frailty status, cognitive function, nutritional and sarcopenia status. Oral function was measured to assess oral hypofunction. The relationship between tongue pressure differences and frailty status, cognitive function, nutritional and sarcopenia status was analysed using logistic regression analyses after adjusting for age and sex. Results: Nine participants (6 men and 3 women; median age, 81 years) had a tongue pressure <23.0 kPa, which was the lowest limit of the standard value of maximum tongue pressure in patients aged ≥70 years. Logistic regression analyses showed that only Question 21, which is related to a lack of fulfilment in daily life, was significantly associated with low tongue pressure (p =.027). Conclusion: Low tongue pressure may be associated with sociopsychological factors in older adults. [ABSTRACT FROM AUTHOR]

Objective: This study aims to investigate how experimental tooth loss affected learning, memory function, and brain pathophysiology in mice. Materials and Methods: The mice (C57BL/6 J, 2‐month‐old, male) were divided into tooth loss and control groups. The behavioral test battery was performed at 6 and 12 months after tooth extraction. The protein levels of the tight junctions in the brains of the mice were analyzed. Hippocampal astrocyte was measured using immunohistochemical staining. Results: The results of behavioral tests and biochemical analysis performed during the 6 months observation period did not show significant differences between the groups. However, the escape latency in the tooth loss group was significantly longer than that in the control group at the 12 months after tooth extraction. The level of claudin‐5 decreased in the tooth loss group. Additionally, hippocampal astrogliosis was found in the tooth loss group. Conclusions: Experimental tooth loss reduced the level of claudin‐5 and caused astrogliosis in the brains of mice, which was accompanied by deterioration of learning functions. This study may provide a new insight about the association between tooth loss and cognitive dysfunction. [ABSTRACT FROM AUTHOR]

The primary concern in carrying out dental implant treatment in patients with chronic myelogenous leukemia is the development of peri-implantitis. However, currently, the advent of molecular-targeted drugs such as nilotinib markedly improves the survival rates in such patients, and it is reported that remission status can be maintained for a long time without abnormalities such as a decrease in white blood cell count. This case history report discusses an 8-year follow-up of implant treatment administered during the remission phase of chronic myelogenous leukemia maintained using nilotinib. A 56-year-old male patient who was undergoing treatment for chronic myelogenous leukemia at the Department of Hematology requested a dental consultation for the treatment of a mastication disorder due to loss of mandibular left molars. After confirming via oral and radiographic examination that there were no abnormalities such as periodontal disease, temporomandibular joint symptoms, or metal allergy, two Brånemark System Mk III implants with diameters of 3.75 and 5 mm and lengths of 10 and 8.5 mm, respectively, were embedded in the defect. Following this, no problems were observed in the general condition, esthetics, or oral function around the implant. Further, symptoms such as mobility of the implant body or inflammation of the surrounding tissue have not appeared to this day, as the molecular-targeted drug decreases the occurrence of immunosuppression, which could not be achieved conventionally. Although this is only one instance, the possibility of implant treatment for chronic myelogenous leukemia patients in the remission phase has been presented in this case. [ABSTRACT FROM AUTHOR]