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This study seeks to expand previous research by examining (a) the prevalence rates of posttraumatic growth (PTG) and its potential predictors (posttraumatic stress symptoms [PTSS], perceived stress, adaptive coping strategies, social support) during the first and second lockdown in the general population of Greece, and (b) the mediating role of the stress indicators (PTSS/perceived stress) in the relationship between positive reframing and PTG. A sample of 1,361 participants (1.009 in the first lockdown and 352 in the second lockdown) completed the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), The Perceived Stress Scale (PSS-10), the Posttraumatic Growth Inventory, the Brief Coping Orientation to Problems Experienced Inventory and the ENRICHD Social Support Instrument (ESSI). Moderate levels of PTG were found during both lockdowns. PTG did not significantly increase during the second lockdown. PTG was associated with PTSS during the first lockdown and with perceived stress during the second one; these two stress indicators partially mediated the positive reframing—PTG relationship in the first and second lockdown, respectively. Both adaptive and maladaptive coping strategies predicted PTG during the first lockdown, whereas only adaptive coping strategies predicted PTG during the second lockdown. Perceived social support, emotional during the first lockdown and instrumental during the second one, predicted PTG during the two lockdowns, respectively. The results of this study may enhance our understanding of PTG and its predictor to inform the design of interventions moving beyond growth cognitions into growth actions. [ABSTRACT FROM AUTHOR]

The aim was to (i) compare the rates of perceived stress, post‐traumatic stress symptoms (PTSS) and other potential correlates (i.e., resilience, social support, coping strategies, and loneliness) in the general population between the two COVID‐19 lockdowns in Greece and (ii) explore risk and protective factors of PTSS. Online data were collected amid the first (timepoint 1‐T1) and second lockdown (timepoint 2‐T2) by 1009 and 352 participants, respectively. The PTSD Checklist for DSM‐5 and the Perceived Stress Scale measured levels of PTSS and perceived stress. The Brief Resilience Scale, the COPE, the revised UCLA Loneliness Scale, and the ENRICHD Social Support Instrument measured resilience, coping strategies, loneliness, and social support, respectively. Higher levels of PTSS and perceived stress were reported during T2, compared to T1. Clinically significant levels of PTSS were presented by 26.1% and 35.5% of the participants during T1 and T2, respectively. Higher levels of loneliness and use of maladaptive coping strategies and lower levels of social support, resilience and use of adaptive coping strategies were also found. During both lockdowns, PTSS were predicted by perceived stress, loneliness, reduced resilience and the coping strategies of denial and self‐blame. PTSS were associated with younger age, female gender, being single, not having children, and the evaluation of the pandemic as a crisis. The findings highlight the significant public mental health concerns during the COVID‐19 lockdowns. Understanding the risk and protective factors against PTSS and focusing on vulnerable populations should be prioritized by the governments worldwide in the development of evidence‐based interventions. [ABSTRACT FROM AUTHOR]

The study examined whether online and offline social capital and offline social support are associated with less perceived stress in 403 undergraduate Greek college students through the mediating role of resilience and life satisfaction. Gender differences were also explored. A path analysis explored the relationships among the study variables and multi‐group analysis explored gender differences. Perceived stress was predicted indirectly by offline social support and offline bonding social capital through resilience and life satisfaction and directly by online bonding. However, offline bonding was associated with reduced resilience and life satisfaction, whereas social support was associated with increased levels of both. Interestingly, whereas offline bonding was associated with reduced perceived stress through resilience for women, for men it occurred through life satisfaction, and it was primarily resilience for women and life satisfaction for men that predicted reduced perceived stress. It was concluded that different personal ties/relationships are associated with perceived stress through diversified pathways and the pathways are different for men and women. Offline social support between closely tied persons is positively associated and offline bonding is negatively associated with the inner resources for a person to cope with stress, whereas online bonding is beneficial in directly decreasing stress. [ABSTRACT FROM AUTHOR]

Studies have suggested that social workers being indirectly exposed to their patients’ COVID-19-related traumatic experiences may have both negative (i.e. secondary traumatic stress symptoms; STS) and positive psychological consequences (i.e. resilience and vicarious post-traumatic growth (VPTG)). However, less is known about the coping strategies that they use to effectively respond to COVID-19-related challenges. The purpose of this study is to examine the coping strategies that social workers use and their differential association with VPTG, resilience, and STS. A cross-sectional survey was conducted in a sample of 133 social workers (86.7% women, mean age 38.1 ± 9.4 years). They completed the Brief COPE, the Secondary Traumatic Stress Scale (STSS), the Brief Resilience Scale (BRS), and the Post-Traumatic Growth Inventory (PTGI) to measure coping strategies, STS, resilience, and VPTG, respectively. Social workers demonstrated moderate levels of STS, VPTG, and resilience. Denial was associated with STS, positive reframing, planning, and self-blame (inversely) were associated with resilience, and instrumental support and religious coping were associated with VPTG. The results of this study provide insights on how healthcare policies and interventions can best support professionals during current and future pandemics by alleviating levels of STS and enhancing resilience and VPTG. [ABSTRACT FROM AUTHOR]

Research has found gambling to be related to a variety of other addictive behaviours. The study objective was to evaluate the association of Internet gambling with Internet addiction, online sexual engagement, suicidality and substance use, in a sample of Greek adults. The study sample consisted of 789 military personnel. During their annual medical examination the study participants anonymously completed a series of self-reported questionnaires in relation to socio-demographic data, Internet gambling practices, online sexual engagement, Internet addiction, suicidality and psychoactive substance use. We found that Internet addiction significantly predicted engagement with online gambling, followed by substance use in general, and, in particular, the use of cocaine or heroin. Finally, two other predictive indicators were self-reported suicide attempts and engagement with online sex. Online gambling is associated with various behaviours related to impulsivity such as Internet addiction, online sexual engagement, suicidality and substance use. Future research will increase our knowledge on the contribution of new technologies and the Internet in Internet gambling dimensions, as well as on the associations with other high-risk behaviours such as substance use, pornography and suicidality. [ABSTRACT FROM PUBLISHER]

Background/aim: Concerning primary central nervous system neoplasms, meningiomas demonstrate the most common type in adults worldwide. Deregulation of apoptotic pathways in malignancies, including meningiomas, is correlated with chemoresistance and poor prognosis. Caspases represent crucial proteins that induce cell apoptosis. This study aimed to correlate caspase 3 protein expression levels to meningioma clinic-pathological features., Materials and Methods: A set of fifty (n=50) meningioma lesions was included in the current analysis including a broad spectrum of histopathological subtypes (meningotheliomatous, psammomatus, transitional, fibrous, angiomatous, microcystic, atypical and anaplastic). Immunohistochemistry was implemented on tissue microarray cores of selected paraffin blocks by applying an anti-caspase 3 antibody. Additionally, an image analysis protocol was also performed in the corresponding immunostained slides., Results: Caspase 3 protein over-expression was detected in 17/50 (34%) cases, whereas the remaining 33 cases (66%) were characterized by medium to low levels of the molecule. Caspase 3 expression was statistically significantly associated with the grade of the analyzed tumors and the mitotic index (p=0.002, p=0.001, respectively). Caspase 3 expression status was also correlated with the histotype of the selected meningiomas (p=0.016)., Conclusion: Caspase 3 demonstrated low expression levels in a significant subset of the examined meningiomas correlated with differentiation grade, mitotic activity, and partially with specific histotypes. Agents that could enhance caspase 3 expression - inducing its apoptotic activity - represent a very promising area in oncology for developing novel treatment regimens., Competing Interests: The Authors have no financial or non-financial interests to disclose., (©2024 The Author(s). Published by the International Institute of Anticancer Research.)

Objective: Health care workers (HCWs) are at risk for suffering negative psychological consequences of the COVID-19 pandemic, such as secondary traumatic stress symptoms (STS), as they are exposed to this traumatic experience both directly, as community residents, and indirectly, in the care of infected patients. Following vicarious exposure, positive psychological outcomes, such as vicarious posttraumatic growth (VPTG), are also likely, though they are less studied. The present study aims to examine (a) the associations among STS, VPTG, and coping strategies among HCWs during the COVID-19 lockdown and (b) the mediating role of coping strategies in the STS-VPTG relationship., Method: Cross-sectional online data were collected amid the COVID-19 lockdown in Greece (March 23, 2020 through May 3, 2020) from a sample of 647 HCWs (25% men, 75% women). The Secondary Traumatic Stress Scale, the Post Traumatic Growth Inventory, and the Brief Coping Orientation to Problems Experienced Inventory were used to measure STS, VPTG, and coping strategies, respectively., Results: HCWs reported moderate to low levels of STS and VPTG, with the VPTG dimensions of personal strength and appreciation of life being the highest categories. Intrusions mental and both adaptive and maladaptive coping strategies predicted VPTG. Adaptive coping strategies partially mediated the relationship between STS and VPTG, whereas maladaptive coping strategies fully mediated this relationship., Conclusions: Understanding the coping responses during lockdown among HCWs is important for developing tailored prevention and intervention actions to protect the populations at risk from the deleterious impacts of uncontrollable and life-threatening diseases and promote posttraumatic growth. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Purpose: Peroxiredoxins (Prdxs) represent a family of proteins that act as antioxidant enzymes and are involved in a variety of metabolic functions including mainly the intracellular hydrogen peroxide (H2O2) levels reduction. Especially, Prdx-6 protein encoded by the PRDX6 gene (1q25.1) regulates also phospholipid modifications and induces response to oxidative stress and injuries. Our aim was to investigate the expression of Prdx-6 in colon adenocarcinoma (CA)., Methods: A series of 30 formalin-fixed, paraffin-embedded primary CAs tissue sections were used and analyzed. Immunohistochemistry was performed using an anti-Prdx-6 antibody. Digital image analysis was also implemented for evaluating objectively the protein expression levels on the corresponding stained cells., Results: Prdx-6 protein overexpression (increased immunostaining levels) was observed in 12/30 (40%) cases, whereas 18/30 (60%) CA tissues demonstrated low to moderate protein levels, respectively. Prdx-6 overall expression was strongly associated with the stage of the examined tumors (p=0.011), whereas other statistical significances were not assessed (inflammatory infiltration: p=0.364; carcinoma location: p=0.93; differentiation grade: p=0.517; tumor diameter: p=0.983; ulceration: p=0.622)., Conclusions: Prdx-6 overexpression is observed in a significant subset of CAs correlating with aggressive biological behavior (advanced stage). Prdx-6 is a crucial enzyme for oxidative stress/injury endogenous cell response and should be an interesting agent as a biomarker and potential therapeutic target.