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5. Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption.

Author

Tsoi, Bun, Zhang, Huan, So, Chun-Pang, Lam, Angel Ka-Kei, Poon, Christina Chui-Wa, Law, Sek-Lun, Wong, Bing-Lou, and Seto, Sai-Wang

Subjects
LABORATORY rats, CATTLE, PROTEOLYSIS, ALCOHOL drinking, GASTROINTESTINAL system
Abstract

Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from Bos taurus on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Additional file 3 of Angong Niuhuang Wan reduces hemorrhagic transformation and mortality in ischemic stroke rats with delayed thrombolysis: involvement of peroxynitrite-mediated MMP-9 activation

Author

Chen, Hansen, Luo, Yunxia, Tsoi, Bun, Gu, Bing, Qi, Suhua, and Shen, Jiangang

Subjects
nervous system, animal diseases, cardiovascular system, cardiovascular diseases, nervous system diseases
Abstract

Additional file 3. Control of the anesthesia time and body temperature during the MCAO surgery. A, total anesthesia time of rats during MCAO surgery in different groups. B, Body temperatures of rats in different groups before and after the MCAO surgery.

Published
2022
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13. Additional file 7 of Angong Niuhuang Wan reduces hemorrhagic transformation and mortality in ischemic stroke rats with delayed thrombolysis: involvement of peroxynitrite-mediated MMP-9 activation

Author

Chen, Hansen, Luo, Yunxia, Tsoi, Bun, Gu, Bing, Qi, Suhua, and Shen, Jiangang

Abstract

Additional file 7. AGNHW extract had no effect on t-PA activity. The t-PA activity was measured with or without the presence of AGNHW water extract (Extract A) or AGNHW ethanol extract (Extract B), at the final concentration of 50 µg/ml. The corresponding vehicle was used as control respectively.

Published
2022
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20. Pharmacological studies on the anxiolytic lignans extract on restraint-stressed mice effect of standardized Schisandra

Author

Chen, Wai-Wei, He, Rong-Rong, Li, Yi-Fang, Li, Shan-Bing, Tsoi, Bun, and Kurihara, Hiroshi

Subjects
Materia medica, Vegetable -- Chemical properties -- Health aspects, Schisandra -- Chemical properties -- Health aspects, Pharmacology -- Research, Antianxiety agents -- Properties, Plant extracts -- Chemical properties -- Health aspects, Biological sciences, Health, Science and technology
Abstract

ARTICLE INFO Keywords: Fructus Schisandrae Schisandra ttgnans extract Anxiety Restraint stress Monoamines ABSTACT Fruits of Fructus Schisandrae were used as sedatives and hypnotics in traditional Chinese medicine for a long [...]

Published
2011
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24. Contributors

Author

Abdi, Sadaf, Ahmad, Irshad, Ali, Hussain, Amani, Reza, Ara, Gulshan, Arantes, Leticia Priscilla, Arrifano, Gabriela de Paula Fonseca, August, Pauline Maciel, Azam, Amalina Ahmad, Barroso-Hernández, Alejandra, Barua, Chandana Choudhury, Benders, Manon J.N.L., Bhattacharya, Pallab, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Rajbir, Bolumbu, Ganaraja, Bora, Birinchi, Brandt, Myrna J.V., Chandrasekhar, G, Chauhan, Kanupriya, Chen, Hansen, Chen, Shuang, Chib, Shivani, Costa, Mario, Crespo-Lopez, Maria Elena, Datta, Aishika, de Theije, Caroline G.M., Devi, Ph. Vivekanandini, Dey, Abhijit, Dhiman, Smreeti, Dhote, Vipin V., do Nascimento, José Luiz Martins, dos Santos, Bernardo Gindri, Duarah, Radali, Dutta, Bhaskar Jyoti, Eissa, Rana Gamal, Emenike, Bright U., Gangwar, Aishwarya, Ghasemi-Kasman, Maryam, Gorji, Narjes, Gupta, Manish Kumar, Gupta, Vishal, Hamoy, Moisés, Heidarimoghadam, Rezvan, Hemachandra Reddy, P., Hoda, Muddasarul, Hsieh, Ching-Liang, Hung, Angela SM, Ikeda, Takashi, Islam, Jasmin, Ismail, Intan Safinar, Kalia, Kiran, Kambalapally, Chandana, Karthikeyan, Akhilasree, Kaushik, Ayansh, Kaviarasi, Sathyasivam, Khan, Adnan, Khan, Ashrafullah, Khan, Salman, Kilor, Vaishali A., Ko, Erik CH, Koga, Yasutoshi, Koon, Johnny CM, Krishnamoorthy, Alagudurai, Krishnan, Uma Maheswari, Lacerda, Diego Cabral, Leung, Ping-Chung, Li, Jimmy, Liu, Zhike, López-Franco, Óscar, Macchi, Barbarella de Matos, Machado, Marina Lopes, Madhavan, Priya, Mainardi, Marco, Malekahmadi, Mahsa, Mallan, Sudhanshu, Mandloi, Avinash Singh, Martami, Fahimeh, Matté, Cristiane, McDonough, Jennifer, Mehrabani, Sanaz, Memariani, Zahra, Mishra, Jayapriya, Mitha, K.V., Moeini, Reihaneh, Mohan Maruga Raja, Muthu Kumaradoss, Morotomi, Nobuo, Murmu, Ankita, Nath, Rajendra, Navik, Umashanker, Naz, Falaq, Neuwirth, Lorenz S., Nijboer, Cora H., Norouzy, Abdolreza, Oliart-Ros, Rosa María, Oliveira, Fábio Rodrigues, Oppong-Gyebi, Anthony, Patale, Priti, Patel, Vinood B., Pawar, Shubhangi H., Peña-Montes, Carolina, Phachonpai, Wathita, Prakash, Chandra, Prashar, Yash, Preedy, Victor R., Qi, Suhua, Quintanilla, Rodrigo A., Raj, Khadga, Rajagopalan, Rukkumani, Rajasekaran, R, Rajendram, Rajkumar, Ram Pravin Kumar, M, Ramanathan, M, Ramírez-Higuera, Abril, Rani, Nidhi, Ranjbar, Akram, Sarmah, Deepaneeta, Savi, Lidia, Schreihofer, Derek A., Sehrawat, Abhishek, Sena, Chubert Bernardo Castro, Sevanan, Murugan, Shab-Bidar, Sakineh, Shal, Bushra, Sharma, Daisy, Sharma, Deepak, Sharma, Eva, Sharma, Prerna, Shen, Jiangang, Siddique, Yasir Hasan, Silva, Edilene Oliveira, Singh, Damanpreet, Singh, Harsh Vikram, Singh, Lovedeep, Singh, Mandeep, Singh, Pramod Kumar, Singh, Randhir, Singh, Shamsher, Singhai, Ashish, Sivanantham, Banudevi, Soares, Félix Alexandre Antunes, Srinivasan, E, Sternbach, Sarah, Suthar, Pramod Kumar, Testa, Giovanna, Thongire, Vrushali, Toffa, Dènahin Hinnoutondji, Tongun, Terdthai, Toscano, Ana Elisa, Tsoi, Bun, Upaganlawar, Aman B., Upasani, Chandrashekhar D., Upganlawar, Aman B., van Elburg, Ruurd M., Vijayabalan, Shantini, Vijayalakshmi, C, Villavicencio-Tejo, Francisca, Visco, Diego Bulcão, Wattanathorn, Jintanaporn, Wei, Tzu-Hsuan, Yavarpour Bali, Hanie, Younis, Nahla Nabil, and Zamberlan, Daniele Coradini

Published
2023
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29. Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice

Author

Yao Xin-Sheng, Yao Nan, Lan Fang, Tsoi Bun, He Rong-Rong, and Kurihara Hiroshi

Subjects
Other systems of medicine, RZ201-999
Abstract

Abstract Background Lutein is an important eye-protective nutrient. This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS)-induced uveitis in mice. Methods Lutein, suspended in drinking water at a final concentration of 12.5 and 25 mg/mL, was administered to mice at 0.1 mL/10 g body weight for five consecutive days. Control and model group received drinking water only. Uveitis was induced by injecting LPS (100 mg per mouse) into the footpad in the model and lutein groups on day 5 after the last drug administration. Eyes of the mice were collected 24 hours after the LPS injection for the detection of indicators using commercial kits and reverse transcription-polymerase chain reaction. Results LPS-induced uveitis was confirmed by significant pathological damage and increased the nitric oxide level in eye tissue of BALB/C mice 24 hours after the footpad injection. The elevated nitric oxide level was significantly reduced by oral administration of lutein (125 and 500 mg/kg/d for five days) before LPS injection. Moreover, lutein decreased the malondialdehyde content, increased the oxygen radical absorbance capacity level, glutathione, the vitamin C contents and total superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Lutein further increased expressions of copper-zinc SOD, manganese SOD and GPx mRNA. Conclusion The antioxidant properties of lutein contribute to the protection against LPS-induced uveitis, partially through the intervention of inflammation process.

Published
2011
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32. A New Gestational Diabetes Mellitus Model, Hyperglycemia-Induced Eye Malformation via Inhibiting Pax6 in Chick Embryo

Author

Zhang, Shi-Jie, primary, Li, Yi-Fang, additional, Tan, Rui-Rong, additional, Tsoi, Bun, additional, Huang, Wen-Shan, additional, Huang, Yi-Hua, additional, Tang, Xiao-Long, additional, Hu, Dan, additional, Yao, Nan, additional, Yang, Xuesong, additional, Kurihara, Hiroshi, additional, Wang, Qi, additional, and He, Rong-Rong, additional

Published
2016
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34. A natural product, resveratrol, protects against high-glucose-induced developmental damage in chicken embryo

Author

Tan, Rui-Rong, primary, Zhang, Shi-Jie, additional, Tsoi, Bun, additional, Huang, Wen-Shan, additional, Zhuang, Xiao-Ji, additional, Chen, Xiao-Yun, additional, Yao, Nan, additional, Mao, Zhong-Fu, additional, Tang, Lu-Ping, additional, Wang, Qi, additional, Kurihara, Hiroshi, additional, Li, Yi-Fang, additional, and He, Rong-Rong, additional

Published
2015
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50. Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats.

Author

Li, Shan ‐ Bing, Li, Yi ‐ Fang, Mao, Zhong ‐ Fu, Hu, Hui ‐ Hua, Ouyang, Shu ‐ Hua, Wu, Yan ‐ Ping, Tsoi, Bun, Gong, Pin, Kurihara, Hiroshi, and He, Rong ‐ Rong

Subjects
TEA analysis, BIOACTIVE compounds, BLOOD pressure, HEART beat, ALKALOIDS
Abstract

BACKGROUND Heavy tea consumption is suggested to be unsuitable for hypertensive people. However, the bioactive substances in different varieties of tea leaves are very different. This study compares the effects of three Chinese teas - C. sinensis, C. ptilophylla and C. assamica var. kucha - on blood pressure (BP) and heart rate in spontaneously hypertensive rats (SHRs). RESULTS Intragastric administration of C. sinensis extract led to an acute increase in systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate in SHRs. However, C. ptilophylla and C. assamica var. kucha exerted no obvious influences on SBP, DBP or heart rate. Similar to the extract of C. sinensis, intragastric administration of caffeine also led to an acute increase in BP and heart rate in SHRs. In contrast, theobromine and theacrine - purine alkaloids predominantly contained in C. ptilophylla and C. assamica var. kucha, respectively - had no pressor effects. The effect of caffeine on BP was related to the regulation of plasma epinephrine and norepinephrine levels in SHRs. CONCLUSION The different effects of C. sinensis, C. ptilophylla and C. assamica var. kucha on BP might be explained, at least partially, by the differences in the varieties and contents of purine alkaloids. © 2014 Society of Chemical Industry [ABSTRACT FROM AUTHOR]

Published
2015
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