7 results on '"Tsocheva I"'
Search Results
2. Investigating the impact of London’s Ultra Low Emission Zone (ULEZ) on children’s respiratory health: Lung function of participants in the CHILL Study
- Author
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Sartori, L, primary, Kalsi, H S, additional, Scales, J, additional, Tsocheva, I, additional, Dove, R, additional, Chavda, J, additional, Colligan, G, additional, Wood, H E, additional, Cross, L, additional, Moon, J, additional, Hall, A, additional, Newby, C, additional, Mudway, I S, additional, Randhawa, G, additional, and Griffiths, C J, additional
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- 2022
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3. Investigating the impact of London’s Ultra Low Emission Zone on children’s health: Children’s Health in London and Luton (CHILL): Protocol for a prospective parallel cohort study
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James Gauderman, Tsocheva I, Harpal Kalsi, Fletcher M, Ian Mudway, Chris Newby, Grainne Colligan, Frank J. Kelly, Crichlow C, Borislava Mihaylova, J Grigg, Louise Cross, Frances R. Balkwill, Sandra Eldridge, Scales J, Chris Griffiths, Petrovic K, Chavda J, Gurch Randhawa, Sean Beevers, Day B, Thomson A, Wood H, Keating M, John Wright, Keighley A, Tomini F, Aziz Sheikh, Dove R, Mon-Williams M, van Sluijs E, and Hall A
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education.field_of_study ,medicine.medical_specialty ,Public health ,Population ,Air pollution ,Psychological intervention ,medicine.disease_cause ,Political science ,Environmental health ,Cohort ,medicine ,Life course approach ,education ,Air quality index ,Cohort study - Abstract
IntroductionAir pollution harms health across the life course. Children are at particular risk of adverse effects during development, which may impact on health in later life. Interventions that improve air quality are therefore urgently needed not only to improve public health now, but to prevent longer-term increased vulnerability to chronic disease. Low Emission Zones are a public health policy intervention aimed at reducing traffic-derived contributions to urban air pollution, but evidence that they deliver clear health benefits is lacking. We established a natural experiment design study (CHILL: Children’s Health in London and Luton) to evaluate the impacts of the introduction of London’s Ultra Low Emission Zone (ULEZ) on children’s health.Methods and analysisCHILL is a prospective two-arm parallel longitudinal cohort study of children aged 6-9 years, attending primary schools in Central London (the focus of the first phase of the ULEZ) and Luton (a comparator site). The primary goal of the study is to examine the impact of changes in annual air pollutant exposures as oxides of nitrogen, nitrogen dioxide, particulate matter less than 2.5microns and 10microns (NOx, NO2, PM2.5, PM10 respectively) across the two sites on lung growth, measured as forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), over four consecutive years. Secondary outcomes being investigated include a range of respiratory health indicators as well as inequality and health economic measures.Ethics and disseminationEthics approval has been given by Queen Mary University of London Research Ethics Committee (ref 2018/08). Dissemination will target audiences through a variety of channels, including research papers, conference and media presentations, web summaries and social media. CHILL is funded by National Institute for Health Research (NIHR) Public Health Research (Ref 16/139/09) with additional funding by Natural Environment Research Council, NIHR CLAHRC North Thames, NIHR ARC North Thames, and the Mayor of London. ClinicalTrials.gov: NCT04695093Strengths and limitations of this studyStrengthsCHILL uses a prospective parallel cohort design, allowing robust conclusions to be drawn on the impact of the ULEZ - a major city-wide air quality mitigation strategy - on air quality and children’s respiratory health.CHILL study cohorts include children from large and ethnically diverse populations living in urban areas characterised by poor air quality.LimitationsAttrition of study cohort population over time, although this has been accounted for in the original design of the study.Potential diminution of the ULEZ air pollution signal due to pre-compliance with ULEZ restrictions in the run up to the introduction of the scheme in Central London on the 8th April 2019, and minor impacts of other pollution mitigation measures.Added complexity of accounting for effects of COVID-19 and related lockdowns on traffic flows, air quality and children’s health.
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- 2021
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4. Evaluating the impact of London's Ultra Low Emission Zone on children's respiratory health: Spirometry success rates at baseline - the CHILL Study.
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KALSI, H. S., JAMES, S., Dove, R., Helen, W., Louise, C., Tsocheva, I., Chavda, J., Grainne, C., Kristian, P., Newby, C., Randhawa, G., Ian, M., and Griffiths, C.
- Subjects
CHILDREN'S health ,SPIROMETRY - Published
- 2019
5. Children's Health in London and Luton (CHILL) cohort: a 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children's travel to school.
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Xiao C, Scales J, Chavda J, Dove RE, Tsocheva I, Wood HE, Kalsi H, Sartori L, Colligan G, Moon J, Lie E, Petrovic K, Day B, Howett C, Keighley A, Mihaylova B, Toffolutti V, Grigg J, Randhawa G, Sheikh A, Fletcher M, Mudway I, Beevers S, Gauderman WJ, Griffiths CJ, van Sluijs E, and Panter J
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- Humans, Child, London, Male, Female, Prospective Studies, Air Pollution, Walking statistics & numerical data, Exercise, Schools, Child Health
- Abstract
Background: The Ultra-Low Emission Zone (ULEZ), introduced in Central London in April 2019, aims to enhance air quality and improve public health. The Children's Health in London and Luton (CHILL) study evaluates the impact of the ULEZ on children's health. This analysis focuses on the one-year impacts on the shift towards active travel to school., Methods: CHILL is a prospective parallel cohort study of ethnically diverse children, aged 6-9 years attending 84 primary schools within or with catchment areas encompassing London's ULEZ (intervention) and Luton (non-intervention area). Baseline (2018/19) and one-year follow-up (2019/20) data were collected at school visits from 1992 (58%) children who reported their mode of travel to school 'today' (day of assessment). Multilevel logistic regressions were performed to analyse associations between the introduction of the ULEZ and the likelihood of switching from inactive to active travel modes, and vice-versa. Interactions between intervention group status and pre-specified effect modifiers were also explored., Results: Among children who took inactive modes at baseline, 42% of children in London and 20% of children in Luton switched to active modes. For children taking active modes at baseline, 5% of children in London and 21% of children in Luton switched to inactive modes. Relative to the children in Luton, children in London were more likely to have switched from inactive to active modes (OR 3.64, 95% CI 1.21-10.92). Children in the intervention group were also less likely to switch from active to inactive modes (OR 0.11, 0.05-0.24). Moderator analyses showed that children living further from school were more likely to switch from inactive to active modes (OR 6.06,1.87-19.68) compared to those living closer (OR 1.43, 0.27-7.54)., Conclusions: Implementation of clean air zones can increase uptake of active travel to school and was particularly associated with more sustainable and active travel in children living further from school., (© 2024. The Author(s).)
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- 2024
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6. Investigating the impact of London's ultra low emission zone on children's health: children's health in London and Luton (CHILL) protocol for a prospective parallel cohort study.
- Author
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Tsocheva I, Scales J, Dove R, Chavda J, Kalsi H, Wood HE, Colligan G, Cross L, Newby C, Hall A, Keating M, Sartori L, Moon J, Thomson A, Tomini F, Murray A, Hamad W, Tijm S, Hirst A, Vincent BP, Kotala P, Balkwill F, Mihaylova B, Grigg J, Quint JK, Fletcher M, Mon-Williams M, Wright J, van Sluijs E, Beevers S, Randhawa G, Eldridge S, Sheikh A, Gauderman W, Kelly F, Mudway IS, and Griffiths CJ
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- Child, Humans, Cohort Studies, Environmental Exposure adverse effects, Environmental Exposure prevention & control, London, Longitudinal Studies, Particulate Matter, Prospective Studies, Quality of Life, Air Pollution adverse effects, Air Pollution prevention & control, Child Health
- Abstract
Background: Air pollution harms health across the life course. Children are at particular risk of adverse effects during development, which may impact on health in later life. Interventions that improve air quality are urgently needed both to improve public health now, and prevent longer-term increased vulnerability to chronic disease. Low Emission Zones are a public health policy intervention aimed at reducing traffic-derived contributions to urban air pollution, but evidence that they deliver health benefits is lacking. We describe a natural experiment study (CHILL: Children's Health in London and Luton) to evaluate the impacts of the introduction of London's Ultra Low Emission Zone (ULEZ) on children's health., Methods: CHILL is a prospective two-arm parallel longitudinal cohort study recruiting children at age 6-9 years from primary schools in Central London (the focus of the first phase of the ULEZ) and Luton (a comparator site), with the primary outcome being the impact of changes in annual air pollutant exposures (nitrogen oxides [NOx], nitrogen dioxide [NO
2 ], particulate matter with a diameter of less than 2.5micrograms [PM2.5 ], and less than 10 micrograms [PM10 ]) across the two sites on lung function growth, measured as post-bronchodilator forced expiratory volume in one second (FEV1 ) over five years. Secondary outcomes include physical activity, cognitive development, mental health, quality of life, health inequalities, and a range of respiratory and health economic data., Discussion: CHILL's prospective parallel cohort design will enable robust conclusions to be drawn on the effectiveness of the ULEZ at improving air quality and delivering improvements in children's respiratory health. With increasing proportions of the world's population now living in large urban areas exceeding World Health Organisation air pollution limit guidelines, our study findings will have important implications for the design and implementation of Low Emission and Clean Air Zones in the UK, and worldwide., Clinicaltrials: GOV: NCT04695093 (05/01/2021)., (© 2023. The Author(s).)- Published
- 2023
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7. Device-Measured Change in Physical Activity in Primary School Children During the UK COVID-19 Pandemic Lockdown: A Longitudinal Study.
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Scales J, Chavda J, Ikeda E, Tsocheva I, Dove RE, Wood HE, Kalsi H, Colligan G, Griffiths L, Day B, Crichlow C, Keighley A, Fletcher M, Newby C, Tomini F, Balkwill F, Mihaylova B, Grigg J, Beevers S, Eldridge S, Sheikh A, Gauderman J, Kelly F, Randhawa G, Mudway IS, van Sluijs E, and Griffiths CJ
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- Humans, Child, Longitudinal Studies, Pandemics prevention & control, Sedentary Behavior, Communicable Disease Control, Schools, Accelerometry, United Kingdom epidemiology, Exercise, COVID-19 epidemiology, COVID-19 prevention & control
- Abstract
Background: Lockdown measures, including school closures, due to the COVID-19 pandemic have caused widespread disruption to children's lives. The aim of this study was to explore the impact of a national lockdown on children's physical activity using seasonally matched accelerometry data., Methods: Using a pre/post observational design, 179 children aged 8 to 11 years provided physical activity data measured using hip-worn triaxial accelerometers worn for 5 consecutive days prepandemic and during the January to March 2021 lockdown. Multilevel regression analyses adjusted for covariates were used to assess the impact of lockdown on time spent in sedentary and moderate to vigorous physical activity., Results: A 10.8-minute reduction in daily time spent in moderate to vigorous physical activity (standard error: 2.3 min/d, P < .001) and a 33.2-minute increase in daily sedentary activity (standard error: 5.5 min/d, P < .001) were observed during lockdown. This reflected a reduction in daily moderate to vigorous physical activity for those unable to attend school (-13.1 [2.3] min/d, P < .001) during lockdown, with no significant change for those who continued to attend school (0.4 [4.0] min/d, P < .925)., Conclusion: These findings suggest that the loss of in-person schooling was the single largest impact on physical activity in this cohort of primary school children in London, Luton, and Dunstable, United Kingdom.
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- 2023
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