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1. Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Author

Finch, Sarah L., Rosenberg, Alan M., Kusalik, Anthony J., Maleki, Farhad, Rezaei, Elham, Baxter-Jones, Adam, Benseler, Susanne, Boire, Gilles, Cabral, David, Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Guzman, Jaime, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ron M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Stringer, Elizabeth, Tse, Shirley M.L., Tucker, Lori B., Turvey, Stuart E., Szafron, Michael, Whiting, Susan, Yeung, Rae SM, and Vatanparast, Hassan

Published
2021
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9. Contributors

Author

Akikusa, Jonathan, primary, Albani, Salvatore, additional, Allen, Roger, additional, Alsaeid, Khaled, additional, Avčin, Tadej, additional, Babyn, Paul S., additional, Bagga, Arvind, additional, Barron, Karyl S., additional, Becker, Mara L., additional, Benseler, Susanne M., additional, Beukelman, Timothy, additional, Brogan, Paul, additional, Brunner, Hermine I., additional, Burgos-Vargas, Rubèn, additional, Buyon, Jill, additional, Cabral, David A., additional, Choo, Sharon, additional, Cimaz, Rolando, additional, Colbert, Robert Allen, additional, Cole, William G., additional, Davidson, Iris, additional, Benedetti, Fabrizio De, additional, Doria, Andrea S., additional, Dressler, Frank, additional, Duffy, Ciarán M., additional, Eleftheriou, Despina, additional, Feldman, Brian M., additional, Ferguson, Polly J., additional, Fuhlbrigge, Robert, additional, Gattorno, Marco, additional, Grom, Alexei A., additional, Hashkes, Philip J., additional, Houghton, Kristin, additional, Huppertz, Hans-Iko, additional, Ilowite, Norman T., additional, Jaeggi, Edgar, additional, Kastner, Daniel L., additional, Kirton, Adam, additional, Klein-Gitelman, Marisa, additional, Kuchta, Gay, additional, Lane, Jerome Charles, additional, Laxer, Ronald M., additional, LeBlanc, Claire, additional, Leeder, Steven J., additional, Legger, G. Elizabeth, additional, Li, Suzanne C., additional, Lindsley, Carol B., additional, Lovell, Dan, additional, Makitie, Outi, additional, Martini, Alberto, additional, Miller, Frederick W., additional, Morishita, Kimberly, additional, Nigrovic, Peter A., additional, Oen, Kiem G., additional, O'Neil, Kathleen M., additional, Ozen, Seza, additional, Pepmueller, Peri H., additional, Petty, Ross E., additional, Pope, Elena, additional, Prahalad, Sampath, additional, Prakken, Berent, additional, Rapoff, Michael, additional, Rider, Lisa G., additional, Rosé, Carlos Daniel, additional, Rosenbaum, James T., additional, Rosenberg, Alan M., additional, Roth, Johannes, additional, Guillermo, Ricardo Alberto, additional, Schneider, Rayfel, additional, Scott, Christiaan, additional, Sherry, David D., additional, Silverman, Earl, additional, Son, Mary Beth, additional, Sundel, Robert P., additional, Thompson, Susan D., additional, Tiedemann, Karin, additional, Tse, Shirley M.L., additional, Tucker, Lori, additional, Uziel, Yosef, additional, van Montfrans, Joris, additional, Vazques-Mellado, Janitzia, additional, Ward, Leanne, additional, Wedderburn, Lucy R., additional, Wouters, Carine, additional, Wright, James, additional, Wulffraat, Nico M., additional, Zemel, Lawrence, additional, and Zulian, Francesco, additional

Published
2016
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12. Clinical and Psychosocial Stress Factors are Associated with Decline in Physical Activity Over Time in Children with Juvenile Idiopathic Arthritis

Author

Heale, Liane D, primary, Houghton, Kristin, additional, Rezaei, Elham, additional, Baxter-Jones, Adam D.G., additional, Tupper, Susan M, additional, Muhajarine, Nazeem, additional, Benseler, Susanne M, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chedeville, Gaelle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Duffy, Karen Watanabe, additional, Ellsworth, Janet, additional, Guzman, Jaime, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Laxer, Ronald M, additional, Morishita, Kimberly, additional, Oen, Keim G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tse, Shirley M.L., additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Yeung, Rae S.M., additional, and Rosenberg, Alan M, additional

Published
2021
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16. Chapter Authors

Author

Bechard, Melanie, Helmers, Andrew, McLean, Lianne J., Lirette, Marie-Pier, Harel-Sterling, Maya, Baran, Iwona, Beno, Suzanne, Ladha, Zamin, Thau, Elana, Ratnapalan, Savithiri, Daya, Tahira, Isaac, Lisa, Pancer, Zachary, Gilley, Meghan, Pirie, Jonathan, Singh, Valene, Martin, Samantha, Toulany, Alene, Erdle, Stephanie, Conway, Melanie, Atkinson, Adelle R., Fridman, Michael D., Wong, Jonathan, Papneja, Koyelle, Russell, Jennifer L., Agarwal, Tanvi, Wang, Rebecca, April, Elodie, Cho, Romy, Smith, Jennifer, Morgan, Rodd, Ho, Jane, Masse, Shonna, Morrissey, Laura, Tantuco, Kimberly, Levy, Rebecca, Tilly-Gratton, Audrey, Nguyen, Claire K., Doig, Jenna, Makino, Amber, Jamal, Alisha, Traubici, Jeffrey, Sowemimo, Joju, Sorbara, Julia, Wasserman, Jonathan D., Betcherman, Laura, Ulrich, Emma, Sullivan, Katie, Noone, Damien, Kellar, Ameilia, Crowley, Eileen, Walters, Thomas, Hagel, Jonathon, Wolinska, Justyna M., Azzie, Georges, Mahjoub, Areej, Costain, Gregory, Mendoza-Londono, Roberto, Lam, Justin, Kinlin, Laura, van den Heuvel, Meta, Alexanian-Farr, Mara, Bar-Dayan, Alisa, Beaulieu, Jordan, Gallagher, Kelsey, Kalnins, Daina, Steinberg, Alissa, Tuira, Lori, Vresk, Laura, Welch, Kellie, Currie, Caroline, Mclean, Laura, Sullivan, Samantha, Graham, Ashley, Friedman, Lauren, Millar, Heather, Aggarwal, Anjali, Yan, Adam, Cabric, Vanja, Tole, Soumitra, Cada, Michaela, Scott, Ori, Aujnarain, Amiirah, Kim, Vy, Blanchard, Ana C., Sud, Shama, Morris, Shaun K., Giroux, Ryan, Tam, Jennifer, Bitnun, Ari, Salmers, Gabrielle, Korczak, Daphne J., Krueger, Carsten, Ejaz, Resham, Sondheimer, Neal, Zipursky, Amy, DiLabio, Julia, Kulkarni, Tapas, Moore, Aideen, Riedl, Magdalena, Downie, Mallory L., Blais, Anne Sophie, Santos, Joana Dos, Radhakrishnan, Seetha, Djordjevic, Djurdja, Chatur, Nurin, Go, Cristina Y., Kulkarni, Abhaya, Pulcine, Liza, Lu, Amy, Nuaimi, Mohammed Al, Pabari, Reena, Gupta, Sumit, Thompson, Shelby, Ali, Asim, Shorkey, Allyson, Narayanan, Unni, Greenspoon, Talia, Cushing, Sharon L., Kaufman, Laura, Davidge, Kristen M., Groves, Tyler, Wee, Wallace B., Moraes, Theo J., She, Desmond, Dissanayake, Dilan, Tse, Shirley M.L., Sharma, Suparna, Marano, Maria, Amin, Reshma, Mahant, Sanjay, Duan, Lucy, Woolfson, Jessica P., Roestel, Krista Van, Ng, Vicky, Adeli, Khosrow, Richardson, Susan, Liu, En, Lau, Wendy, Jung, Benjamin, Higgins, Victoria, Bohn, Mary Kathryn, and Lau, Elaine

Published
2022
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17. Feasibility Testing of An Internet-Based Psycho-Educational Game for Children with Juvenile Idiopathic Arthritis and Their Parents

Author

Stinson, Jennifer N., Connelly, Mark, Huber, Adam, Luca, Nadia, Spiegel, Lynn R., Tsimicalis, Argerie, Luca, Stephanie, Tajuddin, Naweed, Berard, Roberta, Barsalou, Julie, Campillo, Sarah, Feldman, Brian, Tse, Shirley M.L., Dancey, Paul, Duffy, Ciarán M., Johnson, Nicole, McGrath, Patrick, Shiff, Natalie J., Tucker, Lori, and Victor, J. Charles

Subjects
human activities, Pediatrics
Abstract

Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common chronic illness in childhood. The responsibility of JIA management during the younger years is shared among family members. However, many families do not receive comprehensive JIA education and coping skills training, which can negatively impact health-related quality of life (HRQL). Evidence supports psycho-educational treatments to improve health outcomes in children with JIA but no program has been developed to meet the needs of 7 to 12-year-old children. The aim of this research is to evaluate the feasibility of a bilingual (English and French) interactive, Internet-based psycho-educational game for children with JIA. Methods: A pilot randomized controlled trial (RCT) design with a usual care control group is underway (target n = 120). Recruitment is ongoing at four Canadian pediatric tertiary care centres and three additional centres will start upon completion of study setup. After informed consent is obtained and baseline questionnaires are completed, participants are randomized. Over the 8-week study period, participants in the experimental group are asked to download the game onto a personal device (i.e., computer or iPad) and interact with the game daily. Participants in the control group receive usual care and are offered the program after post-study. Parents of participants in both groups receive access to the ‘JIA Resource Centre’. Post-study questionnaires are completed following 8-weeks. Implementation outcomes are analyzed using descriptive statistics. Results: To date, 57 participant dyads have enrolled in the study. Of these, 30 have completed the study, 24 are currently in progress, and 3 have dropped out. Reasons for dropping out included, failure to download the game due to technical difficulties (1 dyad) or lack of time (2 dyads). On average, dyads have taken 7.8 (SD = 6.5) days to download the game. Additional directions or prompts for families to download the game was required from the team for 61.3% (n = 19) of intervention participants and of these, the team contacted dyads an average of 5.4 (SD = 3.6) times before the download was successful. For 22.6% (n = 7), a change of device type was required for a successful download. On average, participants have gotten through 31.2% of game content at the end of 8-weeks. Participants were contacted at the 2-week mark (40.9%) and 5-week mark (78.9%) during the study period to follow-up on the lower than expected progress in the game. The response to the intervention has been mostly positive, however, some participants indicated that the level of difficulty was either “too easy” or “too hard” and some considered it too repetitive. Participants appreciated that a game had been developed for their disease population. Conclusion: The feasibility of this intervention would benefit from an easier distribution procedure as well as compatibility of the game across more platforms (i.e., older iPad versions). The level of difficulty could be better suited if tailored to the child’s age. Next steps include development of a tutorial to assist younger participants. Upon completion of data collection, preliminary effectiveness outcomes will be analyzed.

Published
2017

18. Spondyloarthritis Research Consortium of Canada Scoring System for Sacroiliitis in Juvenile Spondyloarthritis/Enthesitis-related Arthritis: A Reliability, Validity, and Responsiveness Study

Author

Panwar, Jyoti, primary, Tse, Shirley M.L., additional, Lim, Lillian, additional, Tolend, Mirkamal A., additional, Radhakrishnan, Shilpa, additional, Salman, Muayad, additional, Moineddin, Rahim, additional, Doria, Andrea S., additional, and Stimec, Jennifer, additional

Published
2019
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19. Contributors

Author

Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Allen, Roger, Alsaeid, Khaled, Avčin, Tadej, Balevic, Stephen, Banwell, Brenda, Barron, Karyl, Barsalou, Julie, Becker, Mara L., Behrens, Edward M., Beresford, Michael W., Beukelman, Timothy, Bockenstedt, Linda K., Brogan, Paul, Brunner, Hermine I., Burns, Jane C., Busch, Robert, Cabral, David A., Canna, Scott W., Choo, Sharon, Cimaz, Rolando, Ciurtin, Coziana, Clinch, Jacqui, Colbert, Robert A., Consolaro, Alessandro, Cooper, Jennifer C., Cron, Randy Q., Davidson, Iris, Dusser, Perrine, Eleftheriou, Despina, Feldman, Brian Michael, Ferguson, Polly J., Foster, Helen Elisabeth, Fuhlbrigge, Robert C., Funk, Ryan S., Gattorno, Marco, Giancane, Gabriella, Griffiths, Anne, Grom, Alexei A., Harel, Liora, Hashkes, Philip J., Hedrich, Christian Michael, Horneff, Gerd, Houghton, Kristin Michelle, Jaeggi, Edgar, Jariwala, Mehul, Jones, Jordan T., Kastner, Daniel L., Kimura, Yukiko, Klein-Gitelman, Marisa S., Koné-Paut, Isabelle, Laxer, Ronald M., Anne LeBlanc, Claire Marie, Li, Suzanne C., Lindsley, Carol B., Martini, Alberto, Mellins, Elizabeth, Morishita, Kimberly A., Muscal, Eyal, Newburger, Jane W., Nigrovic, Peter A., Nott, Kerstin A., O’Neil, Kathleen M., Ombrello, Michael J., Orme, Lisa, Ozen, Seza, Petty, Ross E., Pilkington, Clarissa A., Pope, Elena, Prahalad, Sampath, Prescott, Steven A., Pääkkönen, Markus, Rabinovich, C. Egla, Ramanan, Athimalaipet V., Ravelli, Angelo, Ricciuto, Amanda, Ringold, Sarah, Rosenbaum, James Todd, Rosenberg, Alan M., Rosendahl, Karen, Rosser, Elizabeth C., Rosé, Carlos Daniel, Roth, Johannes, Ruperto, Nicolino, Schulert, Grant, Scott, Christiaan, Sen, Ethan S., Sherry, David D., Silverman, Earl D., Son, Mary Beth F., Sontichai, Watchareewan, Stevens, Anne M., Stinson, Jennifer N., Stoll, Matthew L., Sullivan, Kathleen, Takken, Tim, Torok, Kathryn S., Tse, Shirley M.L., Tucker, Lori, Unger, Sheila, Uziel, Yosef, van der Net, Janjaap, Vastert, Sebastiaan J., Ward, Leanne M., Wedderburn, Lucy R., Weiss, Pamela F., Wouters, Carine Helena, and Zemel, Lawrence

Published
2021
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21. Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis

Author

Rezaei, Elham, Newkirk, Marianna M., Li, Zhenhong, Gordon, John R., Oen, Kiem G., Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gae¨lle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Morishita, Kimberly A., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M.L., Tucker, Lori B., Turvey, Stuart E., Yeung, Rae S.M., and Rosenberg, Alan M.

Abstract

ObjectivesThis study aimed to expand knowledge about soluble low-density lipoprotein receptor-related protein 1 (sLRP1) in juvenile idiopathic arthritis (JIA) by determining associations of sLRP1 levels in nonsystemic JIA patients with clinical and inflammatory biomarker indicators of disease activity.MethodsPlasma sLRP1 and 44 inflammation-related biomarkers were measured at enrollment and 6 months later in a cohort of 96 newly diagnosed Canadian patients with nonsystemic JIA. Relationships between sLRP1 levels and indicators of disease activity and biomarker levels were analyzed at both visits.ResultsAt enrollment, sLRP1 levels correlated negatively with age and active joint counts. Children showed significantly higher levels of sLRP1 than adolescents (mean ranks: 55.4 and 41.9, respectively; P= 0.02). Participants with 4 or fewer active joints, compared to those with 5 or more active joints, had significantly higher sLRP1 levels (mean ranks: 56.2 and 40.7, respectively; P= 0.006). At enrollment, considering the entire cohort, sLRP1 correlated negatively with the number of active joints (r = –0.235, P= 0.017). In the entire cohort, sLRP1 levels at enrollment and 6 months later correlated with 13 and 6 pro- and antiinflammatory biomarkers, respectively. In JIA categories, sLRP1 correlations with inflammatory markers were significant in rheumatoid factor–negative polyarticular JIA, oligoarticular JIA, enthesitis-related arthritis, and psoriatic arthritis at enrollment. Higher sLRP1 levels at enrollment increased the likelihood of absence of active joints 6 months later.ConclusionPlasma sLRP1 levels correlate with clinical and biomarker indicators of short-term improvement in JIA disease activity, supporting sLRP1 as an upstream biomarker of potential utility for assessing JIA disease activity and outcome prediction.

Published
2021
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22. Management of Juvenile Idiopathic Arthritis 2015: A Position Statement from the Pediatric Committee of the Canadian Rheumatology Association

Author

CELLUCCI, TANIA, primary, GUZMAN, JAIME, additional, PETTY, ROSS E., additional, BATTHISH, MICHELLE, additional, BENSELER, SUSANNE M., additional, ELLSWORTH, JANET E., additional, HOUGHTON, KRISTIN M., additional, LeBLANC, CLAIRE M.A., additional, HUBER, ADAM M., additional, LUCA, NADIA, additional, SCHMELING, HEINRIKE, additional, SHIFF, NATALIE J., additional, SOON, GORDON S., additional, and TSE, SHIRLEY M.L., additional

Published
2016
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23. 2014 Update of the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis. Part I: Principles of the Management of Spondyloarthritis in Canada

Author

Rohekar, Sherry, primary, Chan, Jon, additional, Tse, Shirley M.L., additional, Haroon, Nigil, additional, Chandran, Vinod, additional, Bessette, Louis, additional, Mosher, Dianne, additional, Flanagan, Cathy, additional, Keen, Kevin J., additional, Adams, Karen, additional, Mallinson, Michael, additional, Thorne, Carter, additional, Rahman, Proton, additional, Gladman, Dafna D., additional, and Inman, Robert D., additional

Published
2015
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24. 2014 Update of the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis. Part II: Specific Management Recommendations

Author

Rohekar, Sherry, primary, Chan, Jon, additional, Tse, Shirley M.L., additional, Haroon, Nigil, additional, Chandran, Vinod, additional, Bessette, Louis, additional, Mosher, Dianne, additional, Flanagan, Cathy, additional, Keen, Kevin J., additional, Adams, Karen, additional, Mallinson, Michael, additional, Thorne, Carter, additional, Rahman, Proton, additional, Gladman, Dafna D., additional, and Inman, Robert D., additional

Published
2015
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26. Access to Biologic Therapies in Canada for Children with Juvenile Idiopathic Arthritis

Author

LEBLANC, CLAIRE M.A., primary, LANG, BIANCA, additional, BENCIVENGA, ALMA, additional, CHETAILLE, ANNE-LAURE, additional, DANCEY, PAUL, additional, DENT, PETER, additional, MIETTUNEN, PAIVI, additional, OEN, KIEM, additional, ROSENBERG, ALAN, additional, ROTH, JOHANNES, additional, SCUCCIMARRI, ROSIE, additional, TSE, SHIRLEY M.L., additional, BENSELER, SUSANNE, additional, CABRAL, DAVID A., additional, CAMPILLO, SARAH, additional, CHÉDEVILLE, GAËLLE, additional, DUFFY, CIARAN M., additional, DUFFY, KAREN WATANABE, additional, HADDAD, ELIE, additional, HUBER, ADAM M., additional, LAXER, RONALD, additional, LEVY, DEBORAH, additional, JOHNSON, NICOLE, additional, RAMSEY, SUZANNE, additional, SHIFF, NATALIE, additional, SCHMELING, HEINRIKE, additional, SCHNEIDER, RAYFEL, additional, STRINGER, ELIZABETH, additional, YEUNG, RAE S.M., additional, and TUCKER, LORI B., additional

Published
2012
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27. An Internet-based Self-management Program with Telephone Support for Adolescents with Arthritis: A Pilot Randomized Controlled Trial

Author

STINSON, JENNIFER N., primary, McGRATH, PATRICK J., additional, HODNETT, ELLEN D., additional, FELDMAN, BRIAN M., additional, DUFFY, CIARAN M., additional, HUBER, ADAM M., additional, TUCKER, LORI B., additional, HETHERINGTON, C. ROSS, additional, TSE, SHIRLEY M.L., additional, SPIEGEL, LYNN R., additional, CAMPILLO, SARAH, additional, GILL, NAVREET K., additional, and WHITE, MEGHAN E., additional

Published
2010
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