1,085 results on '"Tsao, Philip S."'
Search Results
2. Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program
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Klarin, Derek, Devineni, Poornima, Sendamarai, Anoop K, Angueira, Anthony R, Graham, Sarah E, Shen, Ying H, Levin, Michael G, Pirruccello, James P, Surakka, Ida, Karnam, Purushotham R, Roychowdhury, Tanmoy, Li, Yanming, Wang, Minxian, Aragam, Krishna G, Paruchuri, Kaavya, Zuber, Verena, Shakt, Gabrielle E, Tsao, Noah L, Judy, Renae L, Vy, Ha My T, Verma, Shefali S, Rader, Daniel J, Do, Ron, Bavaria, Joseph E, Nadkarni, Girish N, Ritchie, Marylyn D, Burgess, Stephen, Guo, Dong-chuan, Ellinor, Patrick T, LeMaire, Scott A, Milewicz, Dianna M, Willer, Cristen J, Natarajan, Pradeep, Tsao, Philip S, Pyarajan, Saiju, and Damrauer, Scott M
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Cardiovascular ,Genetics ,Human Genome ,Prevention ,Aetiology ,2.1 Biological and endogenous factors ,Humans ,Genome-Wide Association Study ,Veterans ,Pedigree ,Aortic Aneurysm ,Thoracic ,Aortic Dissection ,VA Million Veteran Program ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
The current understanding of the genetic determinants of thoracic aortic aneurysms and dissections (TAAD) has largely been informed through studies of rare, Mendelian forms of disease. Here, we conducted a genome-wide association study (GWAS) of TAAD, testing ~25 million DNA sequence variants in 8,626 participants with and 453,043 participants without TAAD in the Million Veteran Program, with replication in an independent sample of 4,459 individuals with and 512,463 without TAAD from six cohorts. We identified 21 TAAD risk loci, 17 of which have not been previously reported. We leverage multiple downstream analytic methods to identify causal TAAD risk genes and cell types and provide human genetic evidence that TAAD is a non-atherosclerotic aortic disorder distinct from other forms of vascular disease. Our results demonstrate that the genetic architecture of TAAD mirrors that of other complex traits and that it is not solely inherited through protein-altering variants of large effect size.
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- 2023
3. Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation
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Zheng, Shufen, Tsao, Philip S., and Pan, Cuiping
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- 2024
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4. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Suzuki, Ken, Hatzikotoulas, Konstantinos, Southam, Lorraine, Taylor, Henry J., Yin, Xianyong, Lorenz, Kim M., Mandla, Ravi, Huerta-Chagoya, Alicia, Melloni, Giorgio E. M., Kanoni, Stavroula, Rayner, Nigel W., Bocher, Ozvan, Arruda, Ana Luiza, Sonehara, Kyuto, Namba, Shinichi, Lee, Simon S. K., Preuss, Michael H., Petty, Lauren E., Schroeder, Philip, Vanderwerff, Brett, Kals, Mart, Bragg, Fiona, Lin, Kuang, Guo, Xiuqing, Zhang, Weihua, Yao, Jie, Kim, Young Jin, Graff, Mariaelisa, Takeuchi, Fumihiko, Nano, Jana, Lamri, Amel, Nakatochi, Masahiro, Moon, Sanghoon, Scott, Robert A., Cook, James P., Lee, Jung-Jin, Pan, Ian, Taliun, Daniel, Parra, Esteban J., Chai, Jin-Fang, Bielak, Lawrence F., Tabara, Yasuharu, Hai, Yang, Thorleifsson, Gudmar, Grarup, Niels, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloé, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Kwak, Soo-Heon, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-Min, Nongmaithem, Suraj S., Noordam, Raymond, Lim, Victor J. Y., Tam, Claudia H. T., Joo, Yoonjung Yoonie, Chen, Chien-Hsiun, Raffield, Laura M., Prins, Bram Peter, Nicolas, Aude, Yanek, Lisa R., Chen, Guanjie, Brody, Jennifer A., Kabagambe, Edmond, An, Ping, Xiang, Anny H., Choi, Hyeok Sun, Cade, Brian E., Tan, Jingyi, Broadaway, K. Alaine, Williamson, Alice, Kamali, Zoha, Cui, Jinrui, Thangam, Manonanthini, Adair, Linda S., Adeyemo, Adebowale, Aguilar-Salinas, Carlos A., Ahluwalia, Tarunveer S., Anand, Sonia S., Bertoni, Alain, Bork-Jensen, Jette, Brandslund, Ivan, Buchanan, Thomas A., Burant, Charles F., Butterworth, Adam S., Canouil, Mickaël, Chan, Juliana C. N., Chang, Li-Ching, Chee, Miao-Li, Chen, Ji, Chen, Shyh-Huei, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Cushman, Mary, Danesh, John, Das, Swapan K., de Silva, H. Janaka, Dedoussis, George, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Duan, Qing, Eckardt, Kai-Uwe, Emery, Leslie S., Evans, Daniel S., Evans, Michele K., Fischer, Krista, Floyd, James S., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Freedman, Barry I., Genter, Pauline, Gerstein, Hertzel C., Giedraitis, Vilmantas, González-Villalpando, Clicerio, González-Villalpando, Maria Elena, Gordon-Larsen, Penny, Gross, Myron, Guare, Lindsay A., Hackinger, Sophie, Hakaste, Liisa, Han, Sohee, Hattersley, Andrew T., Herder, Christian, Horikoshi, Momoko, Howard, Annie-Green, Hsueh, Willa, Huang, Mengna, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Ikram, Mohammad Arfan, Ingelsson, Martin, Islam, Md. Tariqul, Isono, Masato, Jang, Hye-Mi, Jasmine, Farzana, Jiang, Guozhi, Jonas, Jost B., Jørgensen, Torben, Kamanu, Frederick K., Kandeel, Fouad R., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kaur, Varinderpal, Kawaguchi, Takahisa, Keaton, Jacob M., Kho, Abel N., Khor, Chiea-Chuen, Kibriya, Muhammad G., Kim, Duk-Hwan, Kronenberg, Florian, Kuusisto, Johanna, Läll, Kristi, Lange, Leslie A., Lee, Kyung Min, Lee, Myung-Shik, Lee, Nanette R., Leong, Aaron, Li, Liming, Li, Yun, Li-Gao, Ruifang, Ligthart, Symen, Lindgren, Cecilia M., Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Locke, Adam E., Louie, Tin, Luan, Jian’an, Luk, Andrea O., Luo, Xi, Lv, Jun, Lynch, Julie A., Lyssenko, Valeriya, Maeda, Shiro, Mamakou, Vasiliki, Mansuri, Sohail Rafik, Matsuda, Koichi, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mo, Huan, Morris, Andrew D., Moura, Filipe A., Nadler, Jerry L., Nalls, Michael A., Nayak, Uma, Ntalla, Ioanna, Okada, Yukinori, Orozco, Lorena, Patel, Sanjay R., Patil, Snehal, Pei, Pei, Pereira, Mark A., Peters, Annette, Pirie, Fraser J., Polikowsky, Hannah G., Porneala, Bianca, Prasad, Gauri, Rasmussen-Torvik, Laura J., Reiner, Alexander P., Roden, Michael, Rohde, Rebecca, Roll, Katheryn, Sabanayagam, Charumathi, Sandow, Kevin, Sankareswaran, Alagu, Sattar, Naveed, Schönherr, Sebastian, Shahriar, Mohammad, Shen, Botong, Shi, Jinxiu, Shin, Dong Mun, Shojima, Nobuhiro, Smith, Jennifer A., So, Wing Yee, Stančáková, Alena, Steinthorsdottir, Valgerdur, Stilp, Adrienne M., Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorsteinsdottir, Unnur, Tomlinson, Brian, Tran, Tam C., Tsai, Fuu-Jen, Tuomilehto, Jaakko, Tusie-Luna, Teresa, Udler, Miriam S., Valladares-Salgado, Adan, van Dam, Rob M., van Klinken, Jan B., Varma, Rohit, Wacher-Rodarte, Niels, Wheeler, Eleanor, Wickremasinghe, Ananda R., van Dijk, Ko Willems, Witte, Daniel R., Yajnik, Chittaranjan S., Yamamoto, Ken, Yamamoto, Kenichi, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Yusuf, Salim, Zawistowski, Matthew, Zhang, Liang, Zheng, Wei, Raffel, Leslie J., Igase, Michiya, Ipp, Eli, Redline, Susan, Cho, Yoon Shin, Lind, Lars, Province, Michael A., Fornage, Myriam, Hanis, Craig L., Ingelsson, Erik, Zonderman, Alan B., Psaty, Bruce M., Wang, Ya-Xing, Rotimi, Charles N., Becker, Diane M., Matsuda, Fumihiko, Liu, Yongmei, Yokota, Mitsuhiro, Kardia, Sharon L. R., Peyser, Patricia A., Pankow, James S., Engert, James C., Bonnefond, Amélie, Froguel, Philippe, Wilson, James G., Sheu, Wayne H. H., Wu, Jer-Yuarn, Hayes, M. Geoffrey, Ma, Ronald C. W., Wong, Tien-Yin, Mook-Kanamori, Dennis O., Tuomi, Tiinamaija, Chandak, Giriraj R., Collins, Francis S., Bharadwaj, Dwaipayan, Paré, Guillaume, Sale, Michèle M., Ahsan, Habibul, Motala, Ayesha A., Shu, Xiao-Ou, Park, Kyong-Soo, Jukema, J. Wouter, Cruz, Miguel, Chen, Yii-Der Ida, Rich, Stephen S., McKean-Cowdin, Roberta, Grallert, Harald, Cheng, Ching-Yu, Ghanbari, Mohsen, Tai, E-Shyong, Dupuis, Josee, Kato, Norihiro, Laakso, Markku, Köttgen, Anna, Koh, Woon-Puay, Bowden, Donald W., Palmer, Colin N. A., Kooner, Jaspal S., Kooperberg, Charles, Liu, Simin, North, Kari E., Saleheen, Danish, Hansen, Torben, Pedersen, Oluf, Wareham, Nicholas J., Lee, Juyoung, Kim, Bong-Jo, Millwood, Iona Y., Walters, Robin G., Stefansson, Kari, Ahlqvist, Emma, Goodarzi, Mark O., Mohlke, Karen L., Langenberg, Claudia, Haiman, Christopher A., Loos, Ruth J. F., Florez, Jose C., Rader, Daniel J., Ritchie, Marylyn D., Zöllner, Sebastian, Mägi, Reedik, Marston, Nicholas A., Ruff, Christian T., van Heel, David A., Finer, Sarah, Denny, Joshua C., Yamauchi, Toshimasa, Kadowaki, Takashi, Chambers, John C., Ng, Maggie C. Y., Sim, Xueling, Below, Jennifer E., Tsao, Philip S., Chang, Kyong-Mi, McCarthy, Mark I., Meigs, James B., Mahajan, Anubha, Spracklen, Cassandra N., Mercader, Josep M., Boehnke, Michael, Rotter, Jerome I., Vujkovic, Marijana, Voight, Benjamin F., Morris, Andrew P., and Zeggini, Eleftheria
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- 2024
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5. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
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Roychowdhury, Tanmoy, Klarin, Derek, Levin, Michael G., Spin, Joshua M., Rhee, Yae Hyun, Deng, Alicia, Headley, Colwyn A., Tsao, Noah L., Gellatly, Corry, Zuber, Verena, Shen, Fred, Hornsby, Whitney E., Laursen, Ina Holst, Verma, Shefali S., Locke, Adam E., Einarsson, Gudmundur, Thorleifsson, Gudmar, Graham, Sarah E., Dikilitas, Ozan, Pattee, Jack W., Judy, Renae L., Pauls-Verges, Ferran, Nielsen, Jonas B., Wolford, Brooke N., Brumpton, Ben M., Dilmé, Jaume, Peypoch, Olga, Juscafresa, Laura Calsina, Edwards, Todd L., Li, Dadong, Banasik, Karina, Brunak, Søren, Jacobsen, Rikke L., Garcia-Barrio, Minerva T., Zhang, Jifeng, Rasmussen, Lars M., Lee, Regent, Handa, Ashok, Wanhainen, Anders, Mani, Kevin, Lindholt, Jes S., Obel, Lasse M., Strauss, Ewa, Oszkinis, Grzegorz, Nelson, Christopher P., Saxby, Katie L., van Herwaarden, Joost A., van der Laan, Sander W., van Setten, Jessica, Camacho, Mercedes, Davis, Frank M., Wasikowski, Rachael, Tsoi, Lam C., Gudjonsson, Johann E., Eliason, Jonathan L., Coleman, Dawn M., Henke, Peter K., Ganesh, Santhi K., Chen, Y. Eugene, Guan, Weihua, Pankow, James S., Pankratz, Nathan, Pedersen, Ole B., Erikstrup, Christian, Tang, Weihong, Hveem, Kristian, Gudbjartsson, Daniel, Gretarsdottir, Solveig, Thorsteinsdottir, Unnur, Holm, Hilma, Stefansson, Kari, Ferreira, Manuel A., Baras, Aris, Kullo, Iftikhar J., Ritchie, Marylyn D., Christensen, Alex H., Iversen, Kasper K., Eldrup, Nikolaj, Sillesen, Henrik, Ostrowski, Sisse R., Bundgaard, Henning, Ullum, Henrik, Burgess, Stephen, Gill, Dipender, Gallagher, Katherine, Sabater-Lleal, Maria, Surakka, Ida, Jones, Gregory T., Bown, Matthew J., Tsao, Philip S., Willer, Cristen J., and Damrauer, Scott M.
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- 2023
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6. A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality
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Verma, Anurag, Minnier, Jessica, Wan, Emily S, Huffman, Jennifer E, Gao, Lina, Joseph, Jacob, Ho, Yuk-Lam, Wu, Wen-Chih, Cho, Kelly, Gorman, Bryan R, Rajeevan, Nallakkandi, Pyarajan, Saiju, Garcon, Helene, Meigs, James B, Sun, Yan V, Reaven, Peter D, McGeary, John E, Suzuki, Ayako, Gelernter, Joel, Lynch, Julie A, Petersen, Jeffrey M, Zekavat, Seyedeh Maryam, Natarajan, Pradeep, Dalal, Sharvari, Jhala, Darshana N, Arjomandi, Mehrdad, Gatsby, Elise, Lynch, Kristine E, Bonomo, Robert A, Freiberg, Matthew, Pathak, Gita A, Zhou, Jin J, Donskey, Curtis J, Madduri, Ravi K, Wells, Quinn S, Huang, Rose DL, Polimanti, Renato, Chang, Kyong-Mi, Liao, Katherine P, Tsao, Philip S, Wilson, Peter WF, Hung, Adriana M, O’Donnell, Christopher J, Gaziano, John M, Hauger, Richard L, Iyengar, Sudha K, Luoh, Shiuh-Wen, and Initiative, the Million Veteran Program COVID-19 Science
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Lung ,Rare Diseases ,Genetics ,Autoimmune Disease ,Aetiology ,2.1 Biological and endogenous factors ,Respiratory ,Good Health and Well Being ,Humans ,COVID-19 ,Mucin-5B ,Polymorphism ,Genetic ,Idiopathic Pulmonary Fibrosis ,Genotype ,Hospitalization ,Genetic Predisposition to Disease ,coronavirus disease 2019 ,severe acute respiratory syndrome coronavirus 2 ,idiopathic pulmonary fibrosis ,electronic health records ,genetic association ,Million Veteran Program COVID-19 Science Initiative ,Medical and Health Sciences ,Respiratory System - Abstract
Rationale: A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in severe acute respiratory syndrome coronavirus 2 infection and disease severity is unclear. Objectives: To assess whether rs35705950-T confers differential risk for clinical outcomes associated with coronavirus disease (COVID-19) infection among participants in the Million Veteran Program (MVP). Methods: The MUC5B rs35705950-T allele was directly genotyped among MVP participants; clinical events and comorbidities were extracted from the electronic health records. Associations between the incidence or severity of COVID-19 and rs35705950-T were analyzed within each ancestry group in the MVP followed by transancestry meta-analysis. Replication and joint meta-analysis were conducted using summary statistics from the COVID-19 Host Genetics Initiative (HGI). Sensitivity analyses with adjustment for additional covariates (body mass index, Charlson comorbidity index, smoking, asbestosis, rheumatoid arthritis with interstitial lung disease, and IPF) and associations with post-COVID-19 pneumonia were performed in MVP subjects. Measurements and Main Results: The rs35705950-T allele was associated with fewer COVID-19 hospitalizations in transancestry meta-analyses within the MVP (Ncases = 4,325; Ncontrols = 507,640; OR = 0.89 [0.82-0.97]; P = 6.86 × 10-3) and joint meta-analyses with the HGI (Ncases = 13,320; Ncontrols = 1,508,841; OR, 0.90 [0.86-0.95]; P = 8.99 × 10-5). The rs35705950-T allele was not associated with reduced COVID-19 positivity in transancestry meta-analysis within the MVP (Ncases = 19,168/Ncontrols = 492,854; OR, 0.98 [0.95-1.01]; P = 0.06) but was nominally significant (P
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- 2022
7. Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study
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Portilla-Fernandez, Eliana, Klarin, Derek, Hwang, Shih-Jen, Biggs, Mary L, Bis, Joshua C, Weiss, Stefan, Rospleszcz, Susanne, Natarajan, Pradeep, Hoffmann, Udo, Rogers, Ian S, Truong, Quynh A, Völker, Uwe, Dörr, Marcus, Bülow, Robin, Criqui, Michael H, Allison, Matthew, Ganesh, Santhi K, Yao, Jie, Waldenberger, Melanie, Bamberg, Fabian, Rice, Kenneth M, Essers, Jeroen, Kapteijn, Daniek MC, van der Laan, Sander W, de Knegt, Rob J, Ghanbari, Mohsen, Felix, Janine F, Ikram, M Arfan, Kavousi, Maryam, Uitterlinden, Andre G, Roks, Anton JM, Danser, AH Jan, Tsao, Philip S, Damrauer, Scott M, Guo, Xiuqing, Rotter, Jerome I, Psaty, Bruce M, Kathiresan, Sekar, Völzke, Henry, Peters, Annette, Johnson, Craig, Strauch, Konstantin, Meitinger, Thomas, O’Donnell, Christopher J, Dehghan, Abbas, and Program, VA Million Veteran
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Prevention ,Human Genome ,Cardiovascular ,Genetics ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Exome ,Genome-Wide Association Study ,Humans ,Mendelian Randomization Analysis ,Polymorphism ,Single Nucleotide ,Triglycerides ,VA Million Veteran Program ,Biological Sciences ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Progressive dilation of the infrarenal aortic diameter is a consequence of the ageing process and is considered the main determinant of abdominal aortic aneurysm (AAA). We aimed to investigate the genetic and clinical determinants of abdominal aortic diameter (AAD). We conducted a meta-analysis of genome-wide association studies in 10 cohorts (n = 13 542) imputed to the 1000 Genome Project reference panel including 12 815 subjects in the discovery phase and 727 subjects [Partners Biobank cohort 1 (PBIO)] as replication. Maximum anterior-posterior diameter of the infrarenal aorta was used as AAD. We also included exome array data (n = 14 480) from seven epidemiologic studies. Single-variant and gene-based associations were done using SeqMeta package. A Mendelian randomization analysis was applied to investigate the causal effect of a number of clinical risk factors on AAD. In genome-wide association study (GWAS) on AAD, rs74448815 in the intronic region of LDLRAD4 reached genome-wide significance (beta = -0.02, SE = 0.004, P-value = 2.10 × 10-8). The association replicated in the PBIO1 cohort (P-value = 8.19 × 10-4). In exome-array single-variant analysis (P-value threshold = 9 × 10-7), the lowest P-value was found for rs239259 located in SLC22A20 (beta = 0.007, P-value = 1.2 × 10-5). In the gene-based analysis (P-value threshold = 1.85 × 10-6), PCSK5 showed an association with AAD (P-value = 8.03 × 10-7). Furthermore, in Mendelian randomization analyses, we found evidence for genetic association of pulse pressure (beta = -0.003, P-value = 0.02), triglycerides (beta = -0.16, P-value = 0.008) and height (beta = 0.03, P-value
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- 2022
8. Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits
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Patel, Roshni A, Musharoff, Shaila A, Spence, Jeffrey P, Pimentel, Harold, Tcheandjieu, Catherine, Mostafavi, Hakhamanesh, Sinnott-Armstrong, Nasa, Clarke, Shoa L, Smith, Courtney J, Program, VA Million Veteran, Durda, Peter P, Taylor, Kent D, Tracy, Russell, Liu, Yongmei, Johnson, W Craig, Aguet, Francois, Ardlie, Kristin G, Gabriel, Stacey, Smith, Josh, Nickerson, Deborah A, Rich, Stephen S, Rotter, Jerome I, Tsao, Philip S, Assimes, Themistocles L, and Pritchard, Jonathan K
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Epidemiology ,Biological Sciences ,Health Sciences ,Genetics ,Atherosclerosis ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Cholesterol ,LDL ,Gene Expression ,Genome-Wide Association Study ,Humans ,Multifactorial Inheritance ,Polymorphism ,Single Nucleotide ,White People ,V.A. Million Veteran Program ,complex traits ,genetic correlation ,genome-wide association ,population genetics ,statistical genetics ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has been difficult to quantify because GWASs are generally underpowered to detect individual interactions of small effect. Here, we develop a method to test for genetic interactions that aggregates information across all trait-associated loci. Specifically, we test whether SNPs in regions of European ancestry shared between European American and admixed African American individuals have the same causal effect sizes. We hypothesize that in African Americans, the presence of genetic interactions will drive the causal effect sizes of SNPs in regions of European ancestry to be more similar to those of SNPs in regions of African ancestry. We apply our method to two traits: gene expression in 296 African Americans and 482 European Americans in the Multi-Ethnic Study of Atherosclerosis (MESA) and low-density lipoprotein cholesterol (LDL-C) in 74K African Americans and 296K European Americans in the Million Veteran Program (MVP). We find significant evidence for genetic interactions in our analysis of gene expression; for LDL-C, we observe a similar point estimate, although this is not significant, most likely due to lower statistical power. These results suggest that gene-by-gene or gene-by-environment interactions modify the effect sizes of causal variants in human complex traits.
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- 2022
9. Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts
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Zanetti, Daniela, Stell, Laurel, Gustafsson, Stefan, Abbasi, Fahim, Tsao, Philip S., Knowles, Joshua W., Zethelius, Björn, Ärnlöv, Johan, Balkau, Beverley, Walker, Mark, Lazzeroni, Laura C., Lind, Lars, Petrie, John R., and Assimes, Themistocles L.
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- 2023
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10. Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
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Yarmolinsky, James, Bouras, Emmanouil, Constantinescu, Andrei, Burrows, Kimberley, Bull, Caroline J., Vincent, Emma E., Martin, Richard M., Dimopoulou, Olympia, Lewis, Sarah J., Moreno, Victor, Vujkovic, Marijana, Chang, Kyong-Mi, Voight, Benjamin F., Tsao, Philip S., Gunter, Marc J., Hampe, Jochen, Pellatt, Andrew J., Pharoah, Paul D. P., Schoen, Robert E., Gallinger, Steven, Jenkins, Mark A., Pai, Rish K., Gill, Dipender, and Tsilidis, Kostas K.
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- 2023
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11. A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
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Patel, Aniruddh P., Wang, Minxian, Ruan, Yunfeng, Koyama, Satoshi, Clarke, Shoa L., Yang, Xiong, Tcheandjieu, Catherine, Agrawal, Saaket, Fahed, Akl C., Ellinor, Patrick T., Tsao, Philip S., Sun, Yan V., Cho, Kelly, Wilson, Peter W. F., Assimes, Themistocles L., van Heel, David A., Butterworth, Adam S., Aragam, Krishna G., Natarajan, Pradeep, and Khera, Amit V.
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- 2023
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12. Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease
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Sharma, Pranav, Klarin, Derek, Voight, Benjamin F., Tsao, Philip S., Levin, Michael G., and Damrauer, Scott M.
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- 2024
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13. A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
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Vujkovic, Marijana, Ramdas, Shweta, Lorenz, Kim M, Guo, Xiuqing, Darlay, Rebecca, Cordell, Heather J, He, Jing, Gindin, Yevgeniy, Chung, Chuhan, Myers, Robert P, Schneider, Carolin V, Park, Joseph, Lee, Kyung Min, Serper, Marina, Carr, Rotonya M, Kaplan, David E, Haas, Mary E, MacLean, Matthew T, Witschey, Walter R, Zhu, Xiang, Tcheandjieu, Catherine, Kember, Rachel L, Kranzler, Henry R, Verma, Anurag, Giri, Ayush, Klarin, Derek M, Sun, Yan V, Huang, Jie, Huffman, Jennifer E, Creasy, Kate Townsend, Hand, Nicholas J, Liu, Ching-Ti, Long, Michelle T, Yao, Jie, Budoff, Matthew, Tan, Jingyi, Li, Xiaohui, Lin, Henry J, Chen, Yii-Der Ida, Taylor, Kent D, Chang, Ruey-Kang, Krauss, Ronald M, Vilarinho, Silvia, Brancale, Joseph, Nielsen, Jonas B, Locke, Adam E, Jones, Marcus B, Verweij, Niek, Baras, Aris, Reddy, K Rajender, Neuschwander-Tetri, Brent A, Schwimmer, Jeffrey B, Sanyal, Arun J, Chalasani, Naga, Ryan, Kathleen A, Mitchell, Braxton D, Gill, Dipender, Wells, Andrew D, Manduchi, Elisabetta, Saiman, Yedidya, Mahmud, Nadim, Miller, Donald R, Reaven, Peter D, Phillips, Lawrence S, Muralidhar, Sumitra, DuVall, Scott L, Lee, Jennifer S, Assimes, Themistocles L, Pyarajan, Saiju, Cho, Kelly, Edwards, Todd L, Damrauer, Scott M, Wilson, Peter W, Gaziano, J Michael, O’Donnell, Christopher J, Khera, Amit V, Grant, Struan FA, Brown, Christopher D, Tsao, Philip S, Saleheen, Danish, Lotta, Luca A, Bastarache, Lisa, Anstee, Quentin M, Daly, Ann K, Meigs, James B, Rotter, Jerome I, Lynch, Julie A, Rader, Daniel J, Voight, Benjamin F, and Chang, Kyong-Mi
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Genetics ,Liver Disease ,Human Genome ,Digestive Diseases ,Chronic Liver Disease and Cirrhosis ,Aetiology ,2.1 Biological and endogenous factors ,Alanine Transaminase ,Alpha-Ketoglutarate-Dependent Dioxygenase FTO ,Genome-Wide Association Study ,Humans ,Intracellular Signaling Peptides and Proteins ,Lipase ,Membrane Proteins ,Non-alcoholic Fatty Liver Disease ,Polymorphism ,Single Nucleotide ,Protein Serine-Threonine Kinases ,Regeneron Genetics Center ,Geisinger-Regeneron DiscovEHR Collaboration ,EPoS Consortium ,VA Million Veteran Program ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P
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- 2022
14. A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice
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Scorletti, Eleonora, Saiman, Yedidya, Jeon, Sookyoung, Schneider, Carolin V., Buyco, Delfin G., Lin, Chelsea, Himes, Blanca E., Mesaros, Clementina A., Vujkovic, Marijana, Creasy, Kate Townsend, Furth, Emma E., Billheimer, Jeffrey T., Hand, Nicholas J., Kaplan, David E., Chang, Kyong-Mi, Tsao, Philip S., Lynch, Julie A., Dempsey, Joseph L., Harkin, Julia, Bayen, Susovon, Conlon, Donna, Guerraty, Marie, Phillips, Michael C., Rader, Daniel J., and Carr, Rotonya M.
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- 2024
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15. Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
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Bone, William P, Siewert, Katherine M, Jha, Anupama, Klarin, Derek, Damrauer, Scott M, Chang, Kyong-Mi, Tsao, Philip S, Assimes, Themistocles L, Ritchie, Marylyn D, and Voight, Benjamin F
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Neurodegenerative ,Genetics ,Aging ,Neurosciences ,Cardiovascular ,Human Genome ,Acquired Cognitive Impairment ,Brain Disorders ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Alzheimer's Disease ,Detection ,screening and diagnosis ,2.1 Biological and endogenous factors ,4.1 Discovery and preclinical testing of markers and technologies ,Aetiology ,Neurological ,Alzheimer Disease ,Cardiovascular Diseases ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Phenotype ,Polymorphism ,Single Nucleotide ,VA Million Veteran Program ,Cardiometabolic traits ,Colocalization ,Multi-trait GWAS ,Pleiotropy ,Medical and Health Sciences - Abstract
BackgroundIdentification of genetic risk factors that are shared between Alzheimer's disease (AD) and other traits, i.e., pleiotropy, can help improve our understanding of the etiology of AD and potentially detect new therapeutic targets. Previous epidemiological correlations observed between cardiometabolic traits and AD led us to assess the pleiotropy between these traits.MethodsWe performed a set of bivariate genome-wide association studies coupled with colocalization analysis to identify loci that are shared between AD and eleven cardiometabolic traits. For each of these loci, we performed colocalization with Genotype-Tissue Expression (GTEx) project expression quantitative trait loci (eQTL) to identify candidate causal genes.ResultsWe identified three previously unreported pleiotropic trait associations at known AD loci as well as four novel pleiotropic loci. One associated locus was tagged by a low-frequency coding variant in the gene DOCK4 and is potentially implicated in its alternative splicing. Colocalization with GTEx eQTL data identified additional candidate genes for the loci we detected, including ACE, the target of the hypertensive drug class of ACE inhibitors. We found that the allele associated with decreased ACE expression in brain tissue was also associated with increased risk of AD, providing human genetic evidence of a potential increase in AD risk from use of an established anti-hypertensive therapeutic.ConclusionOur results support a complex genetic relationship between AD and these cardiometabolic traits, and the candidate causal genes identified suggest that blood pressure and immune response play a role in the pleiotropy between these traits.
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- 2021
16. peri -Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm
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Mulorz, Joscha, Shayan, Mahdis, Hu, Caroline, Alcazar, Cynthia, Chan, Alex HP, Briggs, Mason, Wen, Yan, Walvekar, Ankita P, Ramasubramanian, Anand K, Spin, Joshua M, Chen, Bertha, Tsao, Philip S, and Huang, Ngan F
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Engineering ,Biomedical and Clinical Sciences ,Biomedical Engineering ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,Cardiovascular ,Stem Cell Research ,Rare Diseases ,Stem Cell Research - Nonembryonic - Human ,Regenerative Medicine ,Orphan Drug ,Stem Cell Research - Induced Pluripotent Stem Cell ,5.2 Cellular and gene therapies ,2.1 Biological and endogenous factors ,Adventitia ,Animals ,Aortic Aneurysm ,Abdominal ,Cells ,Cultured ,Collagen ,Mice ,Myocytes ,Smooth Muscle ,Porosity ,Swine ,Medicinal and Biomolecular Chemistry ,Biochemistry and Cell Biology ,Medical Biotechnology ,Medical biotechnology ,Biomedical engineering - Abstract
Abdominal aortic aneurysm (AAA) is associated with the loss of vascular smooth muscle cells (SMCs) within the vessel wall. Direct delivery of therapeutic cells is challenging due to impaired mechanical integrity of the vessel wall. We hypothesized that porous collagen scaffolds can be an effective vehicle for the delivery of human-derived SMCs to the site of AAA. The purpose was to evaluate if the delivery of cell-seeded scaffolds can abrogate progressive expansion in a mouse model of AAA. Collagen scaffolds seeded with either primary human aortic SMCs or induced pluripotent stem cell derived-smooth muscle progenitor cells (iPSC-SMPs) had >80% in vitro cell viability and >75% cell penetrance through the scaffold's depth, while preserving smooth muscle phenotype. The cell-seeded scaffolds were successfully transplanted onto the murine aneurysm peri-adventitia on day 7 following AAA induction using pancreatic porcine elastase infusion. Ultrasound imaging revealed that SMC-seeded scaffolds significantly reduced the aortic diameter by 28 days, compared to scaffolds seeded with iPSC-SMPs or without cells (acellular scaffold), respectively. Bioluminescence imaging demonstrated that both cell-seeded scaffold groups had cellular localization to the aneurysm but a decline in survival with time. Histological analysis revealed that both cell-seeded scaffold groups had more SMC retention and less macrophage invasion into the medial layer of AAA lesions, when compared to the acellular scaffold treatment group. Our data suggest that scaffold-based SMC delivery is feasible and may constitute a platform for cell-based AAA therapy.
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- 2021
17. Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease
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Levin, Michael G., Huffman, Jennifer E., Verma, Anurag, Sullivan, Kyle A., Rodriguez, Alexis A., Kainer, David, Garvin, Michael R., Lane, Matthew, Cashman, Mikaela, Miller, J. Izaak, Won, Hyejung, Li, Binglan, Luo, Yuan, Jarvik, Gail P., Hakonarson, Hakon, Jasper, Elizabeth A., Bick, Alexander G., Tsao, Philip S., Ritchie, Marylyn D., Jacobson, Daniel A., Madduri, Ravi K., and Damrauer, Scott M.
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- 2023
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18. Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
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Pazoki, Raha, Vujkovic, Marijana, Elliott, Joshua, Evangelou, Evangelos, Gill, Dipender, Ghanbari, Mohsen, van der Most, Peter J, Pinto, Rui Climaco, Wielscher, Matthias, Farlik, Matthias, Zuber, Verena, de Knegt, Robert J, Snieder, Harold, Uitterlinden, André G, Lynch, Julie A, Jiang, Xiyun, Said, Saredo, Kaplan, David E, Lee, Kyung Min, Serper, Marina, Carr, Rotonya M, Tsao, Philip S, Atkinson, Stephen R, Dehghan, Abbas, Tzoulaki, Ioanna, Ikram, M Arfan, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Alizadeh, Behrooz Z, O’Donnell, Christopher J, Saleheen, Danish, Voight, Benjamin F, Chang, Kyong-Mi, Thursz, Mark R, and Elliott, Paul
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Cardiovascular ,Digestive Diseases ,Heart Disease ,Liver Disease ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Oral and gastrointestinal ,Metabolic and endocrine ,Good Health and Well Being ,Aged ,Alanine Transaminase ,Alkaline Phosphatase ,Cardiovascular Diseases ,Cohort Studies ,Databases ,Genetic ,Female ,Gene Expression Regulation ,Enzymologic ,Genetic Predisposition to Disease ,Genetic Testing ,Genome-Wide Association Study ,Humans ,Insulin Resistance ,Lipid Metabolism ,Liver ,Male ,Mendelian Randomization Analysis ,Metabolic Diseases ,Middle Aged ,Polymorphism ,Single Nucleotide ,Risk Factors ,White People ,gamma-Glutamyltransferase ,Lifelines Cohort Study ,VA Million Veteran Program - Abstract
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline study confirms 517 liver enzyme SNPs. Genetic risk score analysis using the identified SNPs is strongly associated with serum activity of liver enzymes in two independent European descent studies (The Airwave Health Monitoring study and the Northern Finland Birth Cohort 1966). Gene-set enrichment analysis using the identified SNPs highlights involvement in liver development and function, lipid metabolism, insulin resistance, and vascular formation. Mendelian randomization analysis shows association of liver enzyme variants with coronary heart disease and ischemic stroke. Genetic risk score for elevated serum activity of liver enzymes is associated with higher fat percentage of body, trunk, and liver and body mass index. Our study highlights the role of molecular pathways regulated by the liver in metabolic disorders and cardiovascular disease.
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- 2021
19. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines
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Isselbacher, Eric M., Preventza, Ourania, Hamilton Black, James, III, Augoustides, John G., Beck, Adam W., Bolen, Michael A., Braverman, Alan C., Bray, Bruce E., Brown-Zimmerman, Maya M., Chen, Edward P., Collins, Tyrone J., DeAnda, Abe, Jr., Fanola, Christina L., Girardi, Leonard N., Hicks, Caitlin W., Hui, Dawn S., Schuyler Jones, William, Kalahasti, Vidyasagar, Kim, Karen M., Milewicz, Dianna M., Oderich, Gustavo S., Ogbechie, Laura, Promes, Susan B., Ross, Elsie Gyang, Schermerhorn, Marc L., Singleton Times, Sabrina, Tseng, Elaine E., Wang, Grace J., Woo, Y. Joseph, Faxon, David P., Upchurch, Gilbert R., Jr, Aday, Aaron W., Azizzadeh, Ali, Boisen, Michael, Hawkins, Beau, Kramer, Christopher M., Luc, Jessica G.Y., MacGillivray, Thomas E., Malaisrie, S. Christopher, Osteen, Kathryn, Patel, Himanshu J., Patel, Parag J., Popescu, Wanda M., Rodriguez, Evelio, Sorber, Rebecca, Tsao, Philip S., Santos Volgman, Annabelle, Beckman, Joshua A., Otto, Catherine M., O'Gara, Patrick T., Armbruster, Anastasia, Birtcher, Kim K., de las Fuentes, Lisa, Deswal, Anita, Dixon, Dave L., Gorenek, Bulent, Haynes, Norrisa, Hernandez, Adrian F., Joglar, José A., Jones, W. Schuyler, Mark, Daniel, Mukherjee, Debabrata, Palaniappan, Latha, Piano, Mariann R., Rab, Tanveer, Spatz, Erica S., and Tamis-Holland, Jacqueline E.
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- 2023
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20. E-Cigarettes and Cardiopulmonary Health
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Tarran, Robert, Barr, R Graham, Benowitz, Neal L, Bhatnagar, Aruni, Chu, Hong W, Dalton, Pamela, Doerschuk, Claire M, Drummond, M Bradley, Gold, Diane R, Goniewicz, Maciej L, Gross, Eric R, Hansel, Nadia N, Hopke, Philip K, Kloner, Robert A, Mikheev, Vladimir B, Neczypor, Evan W, Pinkerton, Kent E, Postow, Lisa, Rahman, Irfan, Samet, Jonathan M, Salathe, Matthias, Stoney, Catherine M, Tsao, Philip S, Widome, Rachel, Xia, Tian, Xiao, DaLiao, and Wold, Loren E
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Medical Physiology ,Biomedical and Clinical Sciences ,Tobacco ,Pediatric ,Electronic Nicotine Delivery Systems ,Prevention ,Cardiovascular ,Generic health relevance ,Good Health and Well Being ,Adolescent ,Young Adult ,Humans ,Nicotine ,Tobacco Products ,Lung ,Cardiovascular Diseases ,e-cigarette ,cardiovascular disease ,pulmonary disease ,policy ,cessation ,Medical physiology - Abstract
E-cigarettes have surged in popularity over the last few years, particularly among youth and young adults. These battery-powered devices aerosolize e-liquids, comprised of propylene glycol and vegetable glycerin, typically with nicotine, flavors, and stabilizers/humectants. Although the use of combustible cigarettes is associated with several adverse health effects including multiple pulmonary and cardiovascular diseases, the effects of e-cigarettes on both short- and long-term health have only begun to be investigated. Given the recent increase in the popularity of e-cigarettes, there is an urgent need for studies to address their potential adverse health effects, particularly as many researchers have suggested that e-cigarettes may pose less of a health risk than traditional combustible cigarettes and should be used as nicotine replacements. This report is prepared for clinicians, researchers, and other health care providers to provide the current state of knowledge on how e-cigarette use might affect cardiopulmonary health, along with research gaps to be addressed in future studies.
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- 2021
21. Abstract 17976: Delivery of Allogeneic Mitochondria Accelerates Revascularization in a Murine Model of Peripheral Arterial Disease and Reverses Metabolic Signatures of Endothelial Senescence
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Headley, Colwyn, Hu, Caroline, Chiang, Gladys, Oropeza, Beu, Tsao, Philip S, and Huang, Ngan F
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- 2023
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22. Abstract 17672: Implications of Pcsk9 on Abdominal Aortic Aneurysm
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Rhee, Yae Hyun, Deng, Alicia, Spin, Joshua M, Headley, Colwyn, and Tsao, Philip S
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- 2023
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23. Abstract 17045: Investigating the Causal Relationship Between Glycemic Trait and Great Vessels Structures Using Mendelian Randomization
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Daria, Tselmen, Alkhairo, Hasan, Levin, Michael, Damrauer, Scott M, Tsao, Philip S, Priest, James, Pirruccello, James, Echouffo, Justin B, and Tcheandjieu, Catherine
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- 2023
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24. Abstract 16503: C-X-C Motif Chemokine Ligand 12 is a Primary Determinant of Coronary Artery Dominance
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Rios, Pam, Zanetti, Daniela, Hilliard, Austin, Naftaly, Jeffrey, Prabala, Pratima, Kho, Pik Fang, Chang, Kyong-Mi, Plomondon, Meg E, Waldo, Stephen, Tsao, Philip S, CLARKE, Shoa L, Horse, Kristy, and Assimes, Themistocles L
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- 2023
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25. Abstract 15566: Dissecting the Genetic Architecture of Intracranial Aneurysms
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Adkar, Shaunak, lynch, julie, Bamezai, Sharika, Sorondo, Sabina, Choi, Ryan, Cabot, John, Levin, Michael, Damrauer, Scott M, Pyarajan, Saiju, Tsao, Philip S, Skirboll, Stephen, Leeper, Nick J, and Klarin, Derek
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- 2023
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26. Abstract 14964: Unsupervised Machine Learning of Imaging-Based Sub-Phenotypes of Aortic Stenosis With Differential Risks of Conduction Disturbances After Transcatheter Aortic Valve Replacement
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El Zeini, Mustapha, Tran, Matthew, Badarabandi, Umarani, Liu, Chun, Chang, Andrew Y, Malik, Sachin, Kang, Guson, Sayed, Nazish, Sallam, Karim, Tsao, Philip S, Wu, Joseph C, and Chen, Ian Y
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- 2023
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27. Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease
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Hung, Adriana M., Assimon, Victoria A., Chen, Hua-Chang, Yu, Zhihong, Vlasschaert, Caitlyn, Triozzi, Jefferson L., Chan, Helen, Wheless, Lee, Wilson, Otis, Shah, Shailja C., Mack, Taralynn, Thompson, Trevor, Matheny, Michael E., Chandrasekar, Saranya, Mozaffari, Sahar V., Chung, Cecilia P., Tsao, Philip, Susztak, Katalin, Siew, Edward D., Estrada, Karol, Gaziano, J. Michael, Graham, Robert R., Tao, Ran, Hoek, Maarten, Robinson-Cohen, Cassianne, Green, Eric M., Bick, Alexander G., Muralidhar, Sumitra, Moser, Jennifer, Deen, Jennifer E., Tsao, Philip S., Gaziano, J. Michael, Hauser, Elizabeth, Kilbourne, Amy, Luoh, Shiuh-Wen, Matheny, Michael, Oslin, Dave, Churby, Lori, Whitbourne, Stacey B., Brewer, Jessica V., Shayan, Shahpoor (Alex), Selva, Luis E., Pyarajan, Saiju, Cho, Kelly, DuVall, Scott L., Brophy, Mary T., Stephens, Brady, Connor, Todd, Argyres, Dean P., Assimes, Tim, Hung, Adriana, Kranzler, Henry, Aguayo, Samuel, Ahuja, Sunil, Alexander, Kathrina, Androulakis, Xiao M., Balasubramanian, Prakash, Ballas, Zuhair, Beckham, Jean, Bhushan, Sujata, Boyko, Edward, Cohen, David, Dellitalia, Louis, Faulk, L. Christine, Fayad, Joseph, Fujii, Daryl, Gappy, Saib, Gesek, Frank, Greco, Jennifer, Godschalk, Michael, Gress, Todd W., Gupta, Samir, Gutierrez, Salvador, Harley, John, Hammer, Kimberly, Hamner, Mark, Hurley, Robin, Iruvanti, Pran, Jacono, Frank, Jhala, Darshana, Kinlay, Scott, Klein, Jon, Landry, Michael, Liang, Peter, Liangpunsakul, Suthat, Lichy, Jack, Mahan, C. Scott, Marrache, Ronnie, Mastorides, Stephen, Mates, Elisabeth, Mattocks, Kristin, Meyer, Paul, Moorman, Jonathan, Morgan, Timothy, Murdoch, Maureen, Norton, James, Okusaga, Olaoluwa, Oursler, Kris Ann, Palacio, Ana, Poon, Samuel, Potter, Emily, Rauchman, Michael, Servatius, Richard, Sharma, Satish, Smith, River, Sriram, Peruvemba, Strollo, Patrick, Jr., Tandon, Neeraj, Tsao, Philip, Villareal, Gerardo, Wallbom, Agnes, Walsh, Jessica, Wells, John, Whittle, Jeffrey, Whooley, Mary, Williams, Allison E., Wilson, Peter, Xu, Junzhe, and Yeh, Shing Shing
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- 2023
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28. Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility
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Talwar, James V., Laub, David, Pagadala, Meghana S., Castro, Andrea, Lewis, McKenna, Luebeck, Georg E., Gorman, Bryan R., Pan, Cuiping, Dong, Frederick N., Markianos, Kyriacos, Teerlink, Craig C., Lynch, Julie, Hauger, Richard, Pyarajan, Saiju, Tsao, Philip S., Morris, Gerald P., Salem, Rany M., Thompson, Wesley K., Curtius, Kit, Zanetti, Maurizio, and Carter, Hannah
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- 2023
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29. Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies
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Fang, Huaying, Hui, Qin, Lynch, Julie, Honerlaw, Jacqueline, Assimes, Themistocles L, Huang, Jie, Vujkovic, Marijana, Damrauer, Scott M, Pyarajan, Saiju, Gaziano, J Michael, DuVall, Scott L, O’Donnell, Christopher J, Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter WF, Tsao, Philip S, Sun, Yan, Tang, Hua, Ramoni, Rachel, Breeling, Jim, Huang, Grant, Muralidhar, Sumitra, Moser, Jennifer, Whitbourne, Stacey B, Brewer, Jessica V, Concato, John, Warren, Stuart, Argyres, Dean P, Stephens, Brady, Brophy, Mary T, Humphries, Donald E, Do, Nhan, Shayan, Shahpoor, Nguyen, Xuan-Mai T, Hauser, Elizabeth, Sun, Yan V, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Harley, John, Whittle, Jeffrey, Beckham, Jean, Wells, John, Gutierrez, Salvador, Gibson, Gretchen, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Haddock, Kathlyn Sue, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Buford, Malcolm, Mastorides, Stephen, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Swann, Alan, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Washburn, Ronald, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Callaghan, John, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Gutierrez, Amparo, Schifman, Ronald, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Oehlert, Mary, Wallbom, Agnes, Fernando, Ronald, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Anderson, Gwenevere, Sonel, Elif, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Fayad, Joseph, Hung, Adriana, and Lichy, Jack
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Epidemiology ,Biological Sciences ,Health Sciences ,Genetics ,Human Genome ,Generic health relevance ,Algorithms ,Ethnicity ,Genome-Wide Association Study ,Humans ,Machine Learning ,Racial Groups ,Support Vector Machine ,VA Million Veteran Program ,biobank ,ethnicity-specific trait loci ,genetic ancestry ,multi-ethnic cohort ,self-reported race/ethnicity ,stratified analysis ,trans-ethnic GWAS ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic factors influencing complex traits related to health and disease among minority populations. At the same time, the genetic diversity in these cohorts presents new challenges for analysis and interpretation. We consider the utility of race and/or ethnicity categories in genome-wide association studies (GWASs) of multi-ethnic cohorts. We demonstrate that race/ethnicity information enhances the ability to understand population-specific genetic architecture. To address the practical issue that self-identified racial/ethnic information may be incomplete, we propose a machine learning algorithm that produces a surrogate variable, termed HARE. We use height as a model trait to demonstrate the utility of HARE and ethnicity-specific GWASs.
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- 2019
30. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
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Tcheandjieu, Catherine, Zhu, Xiang, Hilliard, Austin T., Clarke, Shoa L., Napolioni, Valerio, Ma, Shining, Lee, Kyung Min, Fang, Huaying, Chen, Fei, Lu, Yingchang, Tsao, Noah L., Raghavan, Sridharan, Koyama, Satoshi, Gorman, Bryan R., Vujkovic, Marijana, Klarin, Derek, Levin, Michael G., Sinnott-Armstrong, Nasa, Wojcik, Genevieve L., Plomondon, Mary E., Maddox, Thomas M., Waldo, Stephen W., Bick, Alexander G., Pyarajan, Saiju, Huang, Jie, Song, Rebecca, Ho, Yuk-Lam, Buyske, Steven, Kooperberg, Charles, Haessler, Jeffrey, Loos, Ruth J. F., Do, Ron, Verbanck, Marie, Chaudhary, Kumardeep, North, Kari E., Avery, Christy L., Graff, Mariaelisa, Haiman, Christopher A., Le Marchand, Loïc, Wilkens, Lynne R., Bis, Joshua C., Leonard, Hampton, Shen, Botong, Lange, Leslie A., Giri, Ayush, Dikilitas, Ozan, Kullo, Iftikhar J., Stanaway, Ian B., Jarvik, Gail P., Gordon, Adam S., Hebbring, Scott, Namjou, Bahram, Kaufman, Kenneth M., Ito, Kaoru, Ishigaki, Kazuyoshi, Kamatani, Yoichiro, Verma, Shefali S., Ritchie, Marylyn D., Kember, Rachel L., Baras, Aris, Lotta, Luca A., Kathiresan, Sekar, Hauser, Elizabeth R., Miller, Donald R., Lee, Jennifer S., Saleheen, Danish, Reaven, Peter D., Cho, Kelly, Gaziano, J. Michael, Natarajan, Pradeep, Huffman, Jennifer E., Voight, Benjamin F., Rader, Daniel J., Chang, Kyong-Mi, Lynch, Julie A., Damrauer, Scott M., Wilson, Peter W. F., Tang, Hua, Sun, Yan V., Tsao, Philip S., O’Donnell, Christopher J., and Assimes, Themistocles L.
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- 2022
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31. Genome-Wide Association Study of CKD Progression
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Robinson-Cohen, Cassianne, Triozzi, Jefferson L., Rowan, Bryce, He, Jing, Chen, Hua C., Zheng, Neil S., Wei, Wei-Qi, Wilson, Otis D., Hellwege, Jacklyn N., Tsao, Philip S., Gaziano, J. Michael, Bick, Alexander, Matheny, Michael E., Chung, Cecilia P., Lipworth, Loren, Siew, Edward D., Ikizler, T. Alp, Tao, Ran, and Hung, Adriana M.
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- 2023
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32. Deep learning modeling of rare noncoding genetic variants in human motor neurons definesCCDC146as a therapeutic target for ALS
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Zhang, Sai, primary, Moll, Tobias, additional, Rubin-Sigler, Jasper, additional, Tu, Sharon, additional, Li, Shuya, additional, Yuan, Enming, additional, Liu, Menghui, additional, Butt, Afreen, additional, Harvey, Calum, additional, Gornall, Sarah, additional, Alhalthli, Elham, additional, Shaw, Allan, additional, Souza, Cleide Dos Santos, additional, Ferraiuolo, Laura, additional, Hornstein, Eran, additional, Shelkovnikova, Tatyana, additional, van Dijk, Charlotte H., additional, Timpanaro, Ilia S., additional, Kenna, Kevin P., additional, Zeng, Jianyang, additional, Tsao, Philip S., additional, Shaw, Pamela J., additional, Ichida, Justin K., additional, Cooper-Knock, Johnathan, additional, and Snyder, Michael P., additional
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- 2024
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33. Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease
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Agha, Golareh, Mendelson, Michael M, Ward-Caviness, Cavin K, Joehanes, Roby, Huan, TianXiao, Gondalia, Rahul, Salfati, Elias, Brody, Jennifer A, Fiorito, Giovanni, Bressler, Jan, Chen, Brian H, Ligthart, Symen, Guarrera, Simonetta, Colicino, Elena, Just, Allan C, Wahl, Simone, Gieger, Christian, Vandiver, Amy R, Tanaka, Toshiko, Hernandez, Dena G, Pilling, Luke C, Singleton, Andrew B, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Li, Yun, Zhang, Guosheng, Stewart, James D, Floyd, James S, Wiggins, Kerri L, Rotter, Jerome I, Multhaup, Michael, Bakulski, Kelly, Horvath, Steven, Tsao, Philip S, Absher, Devin M, Vokonas, Pantel, Hirschhorn, Joel, Fallin, M Daniele, Liu, Chunyu, Bandinelli, Stefania, Boerwinkle, Eric, Dehghan, Abbas, Schwartz, Joel D, Psaty, Bruce M, Feinberg, Andrew P, Hou, Lifang, Ferrucci, Luigi, Sotoodehnia, Nona, Matullo, Giuseppe, Peters, Annette, Fornage, Myriam, Assimes, Themistocles L, Whitsel, Eric A, Levy, Daniel, and Baccarelli, Andrea A
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Human Genome ,Heart Disease ,Clinical Research ,Prevention ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Cardiovascular ,Genetics ,Adult ,Aged ,Cohort Studies ,Coronary Disease ,CpG Islands ,DNA Methylation ,Europe ,Female ,Genome-Wide Association Study ,Humans ,Incidence ,Leukocytes ,Male ,Middle Aged ,Myocardial Infarction ,Population Groups ,Prognosis ,Prospective Studies ,Risk ,United States ,coronary artery disease ,coronary heart disease ,epigenetics ,genomics ,gene expression regulation ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
BackgroundDNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts.MethodsNine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effect meta-analyses across cohorts.ResultsAmong 11 461 individuals (mean age 64 years, 67% women, 35% African American) free of CHD at baseline, 1895 developed CHD during a mean follow-up of 11.2 years. Methylation levels at 52 CpG (cytosine-phosphate-guanine) sites were associated with incident CHD or myocardial infarction (false discovery rate
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- 2019
34. Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort
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Harrington, Kelly M, Nguyen, Xuan-Mai T, Song, Rebecca J, Hannagan, Keri, Quaden, Rachel, Gagnon, David R, Cho, Kelly, Deen, Jennifer E, Muralidhar, Sumitra, O’Leary, Timothy J, Gaziano, John Michael, Whitbourne, Stacey B, Gaziano, J Michael, Ramoni, Rachel, Breeling, Jim, Chang, Kyong-Mi, Huang, Grant, O’Donnell, Christopher J, Tsao, Philip S, Moser, Jennifer, Brewer, Jessica V, Concato, John, Warren, Stuart, Pharm, D, Argyres, Dean P, Tsao, Philip, Stephens, Brady, Brophy, Mary T, Humphries, Donald E, Do, Nhan, Shayan, Shahpoor, Pyarajan, Saiju, Hauser, Elizabeth, Sun, Yan, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Harley, John, Whittle, Jeffrey, Beckham, Jean, Wells, John, Gutierrez, Salvador, Gibson, Gretchen, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Haddock, Kathlyn Sue, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Buford, Malcolm, Mastorides, Stephen, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Swann, Alan, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Washburn, Ronald, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Callaghan, John, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Gutierrez, Amparo, Schifman, Ronald, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Oehlert, Mary, Wallbom, Agnes, Fernando, Ronald, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Anderson, Gwenevere, Sonel, Elif, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Fayad, Joseph, and Hung, Adriana
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Health Services and Systems ,Health Sciences ,Cardiovascular ,Clinical Research ,Prevention ,2.4 Surveillance and distribution ,Aetiology ,Good Health and Well Being ,Adult ,Aged ,Cardiovascular Diseases ,Cohort Studies ,Female ,Health Status ,Humans ,Male ,Mental Disorders ,Middle Aged ,Migraine Disorders ,Musculoskeletal Diseases ,Physical Fitness ,Prevalence ,Sex Distribution ,Sex Factors ,Smoking ,Surveys and Questionnaires ,United States ,United States Department of Veterans Affairs ,Veterans ,Veterans Health ,Young Adult ,VA Million Veteran Program ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Public Health ,Midwifery ,Public health ,Policy and administration - Abstract
BackgroundThe Department of Veterans Affairs Million Veteran Program (MVP) is the largest ongoing cohort program of its kind, with 654,903 enrollees as of June 2018. The objectives of this study were to examine gender differences in the MVP cohort with respect to response and enrollment rates; demographic, health, and health care characteristics; and prevalence of self-reported health conditions.MethodsThe MVP Baseline Survey was completed by 415,694 veterans (8% women), providing self-report measures of demographic characteristics, health status, and medical history.ResultsRelative to men, women demonstrated a higher positive responder rate (23.0% vs. 16.0%), slightly higher enrollment rate (13.5% vs. 12.9%), and, among enrollees, a lower survey completion rate (59.7% vs. 63.8%). Women were younger, more racially diverse, had higher educational attainment, and were less likely to be married or cohabitating with a partner than men. Women were more likely to report good to excellent health status but poorer physical fitness, and less likely to report lifetime smoking and drinking than men. Compared with men, women veterans showed an increased prevalence of musculoskeletal conditions, thyroid problems, gastrointestinal conditions, migraine headaches, and mental health disorders, as well as a decreased prevalence of gout, cardiovascular diseases, high cholesterol, diabetes, and hearing problems.ConclusionsThese results revealed some substantial gender differences in the research participation rates, demographic profile, health characteristics, and prevalence of health conditions for veterans in the MVP cohort. Findings highlight the need for tailoring recruitment efforts to ensure representation of the increasing women veteran population receiving care through the Veterans Health Administration.
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- 2019
35. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
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Ramdas, Shweta, Judd, Jonathan, Graham, Sarah E., Kanoni, Stavroula, Wang, Yuxuan, Surakka, Ida, Wenz, Brandon, Clarke, Shoa L., Chesi, Alessandra, Wells, Andrew, Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J.M., Wu, Kuan-Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Lee, Wen-Jane, Hsiung, Chao Agnes, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Schönherr, Sebastian, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, E. Warwick, Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Le, Phuong, Feitosa, Mary F., Wojczynski, Mary K., Hemerich, Daiane, Preuss, Michael, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Noah, Tsao L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Emmel, Carina, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Sankareswaran, Alagu, Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul R.H.J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Morgan, Anna, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R.B., Nielsen, Aneta A., Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, He, Karen Y., Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H.H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W., Kraaijeveld, Adriaan O., Beulens, Joline W.J., Shu, Xiao-Ou, Rallidis, Loukianos S., Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W., Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Ida Chen, Yii-Der, Pennell, Craig E., Mori, Trevor A., Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M., Stark, Klaus J., Zimmermann, Martina E., Völzke, Henry, Homuth, Georg, Evans, Michele K., Zonderman, Alan B., Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E., Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J., Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Peyser, Patricia A., Kato, Norihiro, Schulze, Matthias B., Girotto, Giorgia, Böger, Carsten A., Jung, Bettina, Joshi, Peter K., Bennett, David A., De Jager, Philip L., Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J., Munroe, Patricia B., Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J., Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A., Adair, Linda S., Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R., Krauss, Ronald M., Wu, Jer-Yuarn, Zheng, Wei, den Hollander, Anneke I., Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G., Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E., Golightly, Yvonne M., Wilson, James F., Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J., Rao, D.C., Arnett, Donna K., Walker, Mark, Scott, Laura J., Koistinen, Heikki A., Chandak, Giriraj R., Mercader, Josep M., Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, E. Shyong, van Dam, Rob M., Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F., McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I., Palmer, Colin N.A., Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M., Jin, Zi-Bing, Lu, Fan, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, t Hart, Leen M., Elders, Petra J.M., Rader, Daniel J., Damrauer, Scott M., Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D., Loos, Ruth J.F., Province, Michael A., Parra, Esteban J., Cruz, Miguel, Psaty, Bruce M., Brandslund, Ivan, Pramstaller, Peter P., Rotimi, Charles N., Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F.A., Kiemeney, Lambertus, de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W., Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V., Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O., Willems van Dijk, Ko, Watkins, Hugh, Strachan, David P., Grarup, Niels, Sever, Peter, Poulter, Neil, Huey-Herng Sheu, Wayne, Rotter, Jerome I., Dantoft, Thomas M., Karpe, Fredrik, Neville, Matt J., Timpson, Nicholas J., Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T., Pedersen, Nancy L., Magnusson, Patrik K.E., Boomsma, Dorret I., de Geus, Eco J.C., Cupples, L. Adrienne, van Meurs, Joyce B.J., Ikram, Arfan, Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J., Langenberg, Claudia, Zeggini, Eleftheria, Tuomilehto, Jaakko, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C., Kooner, Jaspal S., de Vries, Paul S., Morrison, Alanna C., Hazelhurst, Scott, Ramsay, Michèle, North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G., Whitfield, John B., Abbas, Shahid, Saleheen, Danish, Walters, Robin G., Holmes, Michael V., Black, Corri, Smith, Blair H., Baras, Aris, Justice, Anne E., Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A., Trembath, Richard C., Wei, Wei-Qi, Jarvik, Gail P., Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong-Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, Y. Eugene, Ho, Yuk-Lam, Lynch, Julie A., Tsao, Philip S., Chang, Kyong-Mi, Cho, Kelly, O'Donnell, Christopher J., Gaziano, John M., Wilson, Peter, Mohlke, Karen L., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Boehnke, Michael, Struan Grant, Natarajan, Pradeep, Sun, Yan V., Morris, Andrew P., Deloukas, Panos, Peloso, Gina, Assimes, Themistocles L., Willer, Cristen J., Zhu, Xiang, and Brown, Christopher D.
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- 2022
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36. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
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Kanoni, Stavroula, Graham, Sarah E., Wang, Yuxuan, Surakka, Ida, Ramdas, Shweta, Zhu, Xiang, Clarke, Shoa L., Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J. M., Wu, Kuan-Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Yousri, Noha A., Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Hwu, Chii-Min, Hung, Yi-Jen, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, EWarwick, Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Vazquez-Moreno, Miguel, Feitosa, Mary F., Wojczynski, Mary K., Wang, Zhe, Preuss, Michael H., Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Tsao, Noah L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Le, Phuong, Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Frank, Mirjam, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Bayyana, Swati, Stringham, Heather M., Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul R. H. J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Nardone, Giuseppe Giovanni, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R. B., Nielsen, Aneta A., Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, Li, Xiaoyin, Liang, Jingjing, Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H. H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W., Kraaijeveld, Adriaan O., Beulens, Joline W. J., Shu, Xiao-Ou, Rallidis, Loukianos S., Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W., Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii-Der Ida, Pennell, Craig E., Mori, Trevor A., Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M., Stark, Klaus J., Zimmermann, Martina E., Völzke, Henry, Homuth, Georg, Evans, Michele K., Zonderman, Alan B., Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E., Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J., Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon L. R., Peyser, Patricia A., Kato, Norihiro, Schulze, Matthias B., Girotto, Giorgia, Böger, Carsten A., Jung, Bettina, Joshi, Peter K., Bennett, David A., De Jager, Philip L., Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J., Munroe, Patricia B., Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J., Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A., Adair, Linda S., Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R., Krauss, Ronald M., Wu, Jer-Yuarn, Zheng, Wei, Hollander, Anneke Iden, Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G., Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E., Golightly, Yvonne M., Wilson, James F., Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J., Rao, D. C., Arnett, Donna K., Hunt, Steven C., Walker, Mark, Koistinen, Heikki A., Chandak, Giriraj R., Mercader, Josep M., Costanzo, Maria C., Jang, Dongkeun, Burtt, Noël P., Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, EShyong, van Dam, Rob M., Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F., McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I., Palmer, Colin N. A., Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M., Jin, Zi-Bing, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, Hart, Leen M.‘t, Elders, Petra J. M., Damrauer, Scott M., Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D., Loos, Ruth J. F., Province, Michael A., Parra, Esteban J., Cruz, Miguel, Psaty, Bruce M., Brandslund, Ivan, Pramstaller, Peter P., Rotimi, Charles N., Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F. A., Kiemeney, Lambertus A. L. M., de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W., Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V., Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O., van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P., Grarup, Niels, Sever, Peter, Poulter, Neil, Chuang, Lee-Ming, Rotter, Jerome I., Dantoft, Thomas M., Karpe, Fredrik, Neville, Matt J., Timpson, Nicholas J., Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T., Pedersen, Nancy L., Magnusson, Patrik K. E., Boomsma, Dorret I., Willemsen, Allegonda H. M., Cupples, LAdrienne, van Meurs, Joyce B. J., Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J., Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C., Kooner, Jaspal S., de Vries, Paul S., Morrison, Alanna C., Hazelhurst, Scott, Ramsay, Michèle, North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G., Whitfield, John B., Abbas, Shahid, Saleheen, Danish, Walters, Robin G., Holmes, Michael V., Black, Corri, Smith, Blair H., Baras, Aris, Justice, Anne E., Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A., Trembath, Richard C., Wei, Wei-Qi, Jarvik, Gail P., Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong-Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, YEugene, Ho, Yuk-Lam, Lynch, Julie A., Rader, Daniel J., Tsao, Philip S., Chang, Kyong-Mi, Cho, Kelly, O’Donnell, Christopher J., Gaziano, John M., Wilson, Peter W. F., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Mohlke, Karen L., Sun, Yan V., Morris, Andrew P., Boehnke, Michael, Brown, Christopher D., Natarajan, Pradeep, Deloukas, Panos, Willer, Cristen J., Assimes, Themistocles L., and Peloso, Gina M.
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- 2022
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37. Genomics and phenomics of body mass index reveals a complex disease network
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Huang, Jie, Huffman, Jennifer E., Huang, Yunfeng, Do Valle, Ítalo, Assimes, Themistocles L., Raghavan, Sridharan, Voight, Benjamin F., Liu, Chang, Barabási, Albert-László, Huang, Rose D. L., Hui, Qin, Nguyen, Xuan-Mai T., Ho, Yuk-Lam, Djousse, Luc, Lynch, Julie A., Vujkovic, Marijana, Tcheandjieu, Catherine, Tang, Hua, Damrauer, Scott M., Reaven, Peter D., Miller, Donald, Phillips, Lawrence S., Ng, Maggie C. Y., Graff, Mariaelisa, Haiman, Christopher A., Loos, Ruth J. F., North, Kari E., Yengo, Loic, Smith, George Davey, Saleheen, Danish, Gaziano, J. Michael, Rader, Daniel J., Tsao, Philip S., Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter W. F., Sun, Yan V., and O’Donnell, Christopher J.
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- 2022
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38. Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms
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Lim, Chrysania, Pratama, Muhammad Yogi, Rivera, Cristobal, Silvestro, Michele, Tsao, Philip S., Maegdefessel, Lars, Gallagher, Katherine A., Maldonado, Thomas, and Ramkhelawon, Bhama
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- 2022
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39. The power of genetic diversity in genome-wide association studies of lipids
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Graham, Sarah E., Clarke, Shoa L., Wu, Kuan-Han H., Kanoni, Stavroula, Zajac, Greg J. M., Ramdas, Shweta, Surakka, Ida, Ntalla, Ioanna, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Hwang, Mi Yeong, Han, Sohee, Narita, Akira, Choudhury, Ananyo, Bentley, Amy R., Ekoru, Kenneth, Verma, Anurag, Trivedi, Bhavi, Martin, Hilary C., Hunt, Karen A., Hui, Qin, Klarin, Derek, Zhu, Xiang, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Ruotsalainen, Sanni E., Havulinna, Aki S., Veturi, Yogasudha, Feng, QiPing, Rosenthal, Elisabeth A., Lingren, Todd, Pacheco, Jennifer Allen, Pendergrass, Sarah A., Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Hindy, George, Rasheed, Asif, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Willemsen, Gonneke, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Yao, Jie, Manichaikul, Ani, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Sidore, Carlo, Fiorillo, Edoardo, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Thuesen, Betina H., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Daw, E. Warwick, Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Feitosa, Mary F., Wojczynski, Mary K., Preuss, Michael, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Kember, Rachel L., Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Le, Phuong, Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Leonard, Hampton L., Marten, Jonathan, Schmidt, Börge, Arendt, Marina, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Ahmed, Meraj, Jackson, Anne U., Yousri, Noha A., Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul R. H. J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Chai, Xiaoran, Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Hung, Yi-Jen, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Gorski, Mathias, Brumat, Marco, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Xue, Chao, Zhang, Jifeng, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., Lee, Jiwon, van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Zimmermann, Martina E., Lee, Jong Young, Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hildalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, Li, Xiaoyin, Schwander, Karen, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Highland, Heather M., Young, Kristin L., Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Nadkarni, Girish N., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, Bhatti, Konain Fatima, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H. H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W., Kraaijeveld, Adriaan O., Beulens, Joline W. J., Shu, Xiao-Ou, Rallidis, Loukianos S., Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W., Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii-Der Ida, Pennell, Craig E., Mori, Trevor A., Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M., Stark, Klaus J., Völzke, Henry, Homuth, Georg, Evans, Michele K., Zonderman, Alan B., Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E., Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J., Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Chen, Y. Eugene, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon L. R., Kato, Norihiro, Schulze, Matthias B., Girotto, Giorgia, Jung, Bettina, Böger, Carsten A., Joshi, Peter K., Bennett, David A., De Jager, Philip L., Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J., Munroe, Patricia B., Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J., Kaprio, Jaakko, Pajukanta, Päivi, Adair, Linda S., Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R., Krauss, Ronald M., Wu, Jer-Yuarn, Zheng, Wei, den Hollander, Anneke I., Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G., Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E., Golightly, Yvonne M., Wilson, James F., Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J., Rao, D. C., Arnett, Donna K., Hunt, Steven C., Walker, Mark, Koistinen, Heikki A., Chandak, Giriraj R., Yajnik, Chittaranjan S., Mercader, Josep M., Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A., Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, E. Shyong, van Dam, Rob M., Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F., McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I., Palmer, Colin N. A., Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M., Lu, Fan, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Parra, Esteban J., Cruz, Miguel, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, ’t Hart, Leen M., Elders, Petra J. M., Damrauer, Scott M., Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D., Loos, Ruth J. F., Province, Michael A., Psaty, Bruce M., Brandslund, Ivan, Pramstaller, Peter P., Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F. A., Kiemeney, Lambertus A. L. M., de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W., Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V., Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Cucca, Francesco, Mook-Kanamori, Dennis O., van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P., Grarup, Niels, Sever, Peter, Poulter, Neil, Rotter, Jerome I., Dantoft, Thomas M., Karpe, Fredrik, Neville, Matt J., Timpson, Nicholas J., Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T., Pedersen, Nancy L., Magnusson, Patrik K. E., Boomsma, Dorret I., de Geus, Eco J. C., Cupples, L. Adrienne, van Meurs, Joyce B. J., Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J., Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C., Kooner, Jaspal S., de Vries, Paul S., Morrison, Alanna C., North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G., Whitfield, John B., Abbas, Shahid, Saleheen, Danish, Walters, Robin G., Holmes, Michael V., Black, Corri, Smith, Blair H., Justice, Anne E., Baras, Aris, Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Kooperberg, Charles, Wei, Wei-Qi, Jarvik, Gail P., Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Thorsteinsdottir, Unnur, Stefansson, Kari, Ho, Yuk-Lam, Lynch, Julie A., Rader, Daniel J., Tsao, Philip S., Chang, Kyong-Mi, Cho, Kelly, O’Donnell, Christopher J., Gaziano, John M., Wilson, Peter, Rotimi, Charles N., Hazelhurst, Scott, Ramsay, Michèle, Trembath, Richard C., van Heel, David A., Tamiya, Gen, Yamamoto, Masayuki, Kim, Bong-Jo, Mohlke, Karen L., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Boehnke, Michael, Natarajan, Pradeep, Peloso, Gina M., Brown, Christopher D., Morris, Andrew P., Assimes, Themistocles L., Deloukas, Panos, Sun, Yan V., and Willer, Cristen J.
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- 2021
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40. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
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Song, Rebecca J, Nguyen, Xuan-Mai T, Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C, Gagnon, David R, Cho, Kelly, O'Donnell, Christopher J, Concato, John, Gaziano, J Michael, Djoussé, Luc, Program, VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Robey, Brooks, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, Gibson, Gretchen, and Heinz
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Substance Misuse ,Brain Disorders ,Heart Disease - Coronary Heart Disease ,Alcoholism ,Alcohol Use and Health ,Heart Disease ,Cardiovascular ,Clinical Research ,Atherosclerosis ,Stroke ,Oral and gastrointestinal ,Good Health and Well Being ,Aged ,Alcohol Drinking ,Alcoholic Beverages ,Alcoholism ,Coronary Artery Disease ,Female ,Humans ,Male ,Middle Aged ,Proportional Hazards Models ,Protective Factors ,Risk Factors ,Self Report ,United States ,Veterans ,VA Million Veteran Program ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.
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- 2018
41. DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program
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Djoussé, Luc, Ho, Yuk‐Lam, Nguyen, Xuan‐Mai T, Gagnon, David R, Wilson, Peter WF, Cho, Kelly, Gaziano, J Michael, Program, the VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado‐Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, and Gibson, Gretchen
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,Hypertension ,Atherosclerosis ,Clinical Research ,Cardiovascular ,Prevention ,Good Health and Well Being ,Aged ,Coronary Artery Disease ,Diet ,Healthy ,Dietary Approaches To Stop Hypertension ,Female ,Humans ,Incidence ,Male ,Middle Aged ,Patient Compliance ,Prognosis ,Prospective Studies ,Protective Factors ,Risk Assessment ,Risk Factors ,Risk Reduction Behavior ,Time Factors ,United States ,Veterans Health ,VA Million Veteran Program ,coronary artery disease ,epidemiology ,nutrition ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend,
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- 2018
42. GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
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Lu, Ake T, Xue, Luting, Salfati, Elias L, Chen, Brian H, Ferrucci, Luigi, Levy, Daniel, Joehanes, Roby, Murabito, Joanne M, Kiel, Douglas P, Tsai, Pei-Chien, Yet, Idil, Bell, Jordana T, Mangino, Massimo, Tanaka, Toshiko, McRae, Allan F, Marioni, Riccardo E, Visscher, Peter M, Wray, Naomi R, Deary, Ian J, Levine, Morgan E, Quach, Austin, Assimes, Themistocles, Tsao, Philip S, Absher, Devin, Stewart, James D, Li, Yun, Reiner, Alex P, Hou, Lifang, Baccarelli, Andrea A, Whitsel, Eric A, Aviv, Abraham, Cardona, Alexia, Day, Felix R, Wareham, Nicholas J, Perry, John RB, Ong, Ken K, Raj, Kenneth, Lunetta, Kathryn L, and Horvath, Steve
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Leukocytes ,Cells ,Cultured ,Telomere ,Fibroblasts ,Humans ,Telomerase ,DNA Methylation ,Epigenesis ,Genetic ,CpG Islands ,Aging ,Menopause ,Menarche ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Child ,Female ,Male ,Genome-Wide Association Study ,Young Adult ,Mendelian Randomization Analysis ,Cells ,Cultured ,Epigenesis ,Genetic ,and over - Abstract
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration (EEAA). Mendelian randomization analysis suggests causal influences of menarche and menopause on IEAA and lipoproteins on IEAA and EEAA. Variants associated with longer leukocyte telomere length (LTL) in the telomerase reverse transcriptase gene (TERT) paradoxically confer higher IEAA (P
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- 2018
43. Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis
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Gill, Dipender, Zuber, Verena, Dawson, Jesse, Pearson-Stuttard, Jonathan, Carter, Alice R., Sanderson, Eleanor, Karhunen, Ville, Levin, Michael G., Wootton, Robyn E., Klarin, Derek, Tsao, Philip S., Tsilidis, Konstantinos K., Damrauer, Scott M., Burgess, Stephen, and Elliott, Paul
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- 2021
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44. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines
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Isselbacher, Eric M., Preventza, Ourania, Hamilton Black, James, III, Augoustides, John G., Beck, Adam W., Bolen, Michael A., Braverman, Alan C., Bray, Bruce E., Brown-Zimmerman, Maya M., Chen, Edward P., Collins, Tyrone J., DeAnda, Abe, Jr, Fanola, Christina L., Girardi, Leonard N., Hicks, Caitlin W., Hui, Dawn S., Schuyler Jones, William, Kalahasti, Vidyasagar, Kim, Karen M., Milewicz, Dianna M., Oderich, Gustavo S., Ogbechie, Laura, Promes, Susan B., Gyang Ross, Elsie, Schermerhorn, Marc L., Singleton Times, Sabrina, Tseng, Elaine E., Wang, Grace J., Woo, Y. Joseph, Faxon, David P., Upchurch, Gilbert R., Jr, Aday, Aaron W., Azizzadeh, Ali, Boisen, Michael, Hawkins, Beau, Kramer, Christopher M., Luc, Jessica G.Y., MacGillivray, Thomas E., Malaisrie, S. Christopher, Osteen, Kathryn, Patel, Himanshu J., Patel, Parag J., Popescu, Wanda M., Rodriguez, Evelio, Sorber, Rebecca, Tsao, Philip S., and Santos Volgman, Annabelle
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- 2022
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45. Abstract 14588: A Large-Scale Genome-Wide Association Study of Angiographically Determined Burden of Coronary Atherosclerosis in a Genetically Diverse Population
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Hilliard, Austin, Zanetti, Daniela, lynch, julie, Damrauer, Scott M, Ho, Yuk-lam, Plomondon, Meg E, Waldo, Stephen, Chang, Kyong-Mi, Tsao, Philip S, CLARKE, Shoa L, and Assimes, Themistocles L
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- 2022
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46. Abstract 13662: The Role of Pcsk9 in Abdominal Aortic Aneurysm
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Rhee, Yae Hyun, Spin, Joshua, Deng, Alicia, Headley, Colwyn, and Tsao, Philip S
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- 2022
- Full Text
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47. MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening
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Schellinger, Isabel N., Wagenhäuser, Markus, Chodisetti, Giriprakash, Mattern, Karin, Dannert, Angelika, Petzold, Anne, Jakubizka-Smorag, Joanna, Emrich, Fabian, Haunschild, Josephina, Schuster, Andreas, Schwob, Elisabeth, Schulz, Kei, Maegdefessel, Lars, Spin, Joshua M., Stumvoll, Michael, Hasenfuß, Gerd, Tsao, Philip S., and Raaz, Uwe
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- 2021
- Full Text
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48. A Pilot Study: The Beneficial Effects of Combined Statin-exercise Therapy on Cognitive Function in Patients with Coronary Artery Disease and Mild Cognitive Decline
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Toyama, Kensuke, Sugiyama, Seigo, Oka, Hideki, Hamada, Mari, Iwasaki, Yuri, Horio, Eiji, Rokutanda, Taku, Nakamura, Shinichi, Spin, Joshua M, Tsao, Philip S, and Ogawa, Hisao
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Neurodegenerative ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Cardiovascular ,Brain Disorders ,Alzheimer's Disease ,Clinical Research ,Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Clinical Trials and Supportive Activities ,Aging ,Acquired Cognitive Impairment ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Age Factors ,Aged ,Aged ,80 and over ,Body Mass Index ,Cognitive Dysfunction ,Coronary Artery Disease ,Exercise Therapy ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Hypercholesterolemia ,Lipids ,Male ,Middle Aged ,Neuropsychological Tests ,Odds Ratio ,Physical Fitness ,Pilot Projects ,Risk Factors ,Sex Factors ,statins ,exercise ,cognition ,coronary artery disease ,Public Health and Health Services ,General & Internal Medicine ,Clinical sciences - Abstract
Objective Hypercholesterolemia, a risk factor in cognitive impairment, can be treated with statins. However, cognitive decline associated with "statins" (HMG-CoA reductase inhibitors) is a clinical concern. This pilot study investigated the effects of combining statins and regular exercise on cognitive function in coronary artery disease (CAD) patients with prior mild cognitive decline. Methods We recruited 43 consecutive CAD patients with mild cognitive decline. These patients were treated with a statin and weekly in-hospital aerobic exercise for 5 months. We measured serum lipids, exercise capacity, and cognitive function using the mini mental state examination (MMSE). Results Low-density lipoprotein cholesterol levels were significantly decreased, and maximum exercise capacity (workload) was significantly increased in patients with CAD and mild cognitive decline after treatment compared with before. Combined statin-exercise therapy significantly increased the median (range) MMSE score from 24 (22-25) to 25 (23-27) across the cohort (p65 years, sex, and presence of diabetes mellitus, a decrease in BMI during statin-exercise therapy was significantly correlated with an increase in the MMSE score (odds ratio: 4.57, 95% confidence interval: 1.05-20.0; p
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- 2017
49. Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
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Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., and Casas, Juan P.
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- 2021
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50. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
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Horvath, Steve, Gurven, Michael, Levine, Morgan E, Trumble, Benjamin C, Kaplan, Hillard, Allayee, Hooman, Ritz, Beate R, Chen, Brian, Lu, Ake T, Rickabaugh, Tammy M, Jamieson, Beth D, Sun, Dianjianyi, Li, Shengxu, Chen, Wei, Quintana-Murci, Lluis, Fagny, Maud, Kobor, Michael S, Tsao, Philip S, Reiner, Alexander P, Edlefsen, Kerstin L, Absher, Devin, and Assimes, Themistocles L
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Cardiovascular ,Genetics ,Prevention ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Aging ,Heart Disease ,Good Health and Well Being ,Black or African American ,Aged ,Coronary Disease ,DNA Methylation ,Epigenesis ,Genetic ,Female ,Hispanic or Latino ,Humans ,Male ,Racial Groups ,Risk Factors ,Sex Characteristics ,United States ,White People ,DNA methylation ,Epigenetic clock ,Race ,Gender ,Coronary heart disease ,Hispanic paradox ,Black/white mortality cross-over ,Environmental Sciences ,Biological Sciences ,Information and Computing Sciences ,Bioinformatics - Abstract
BackgroundEpigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence of cardio-metabolic disease such as: (1) women consistently exhibiting lower mortality than men despite having higher levels of morbidity; (2) racial/ethnic groups having different mortality rates even after adjusting for socioeconomic differences; (3) the black/white mortality cross-over effect in late adulthood; and (4) Hispanics in the United States having a longer life expectancy than Caucasians despite having a higher burden of traditional cardio-metabolic risk factors.ResultsWe analyzed blood, saliva, and brain samples from seven different racial/ethnic groups. We assessed the intrinsic epigenetic age acceleration of blood (independent of blood cell counts) and the extrinsic epigenetic aging rates of blood (dependent on blood cell counts and tracks the age of the immune system). In blood, Hispanics and Tsimane Amerindians have lower intrinsic but higher extrinsic epigenetic aging rates than Caucasians. African-Americans have lower extrinsic epigenetic aging rates than Caucasians and Hispanics but no differences were found for the intrinsic measure. Men have higher epigenetic aging rates than women in blood, saliva, and brain tissue.ConclusionsEpigenetic aging rates are significantly associated with sex, race/ethnicity, and to a lesser extent with CHD risk factors, but not with incident CHD outcomes. These results may help elucidate lower than expected mortality rates observed in Hispanics, older African-Americans, and women.
- Published
- 2016
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