Search

Your search keyword '"Tsao, M.S."' showing total 106 results
Start Over Author "Tsao, M.S."
106 results on '"Tsao, M.S."'

1. MA04.05 Transcriptomic Features as Determinant of Therapy Response in Neuroendocrine-Transformed Adenocarcinomas Following TKI

Author

Nunes Martins Filho, S., primary, Mikubo, M., additional, Li, Q., additional, Stewart, E.L., additional, Pham, N.-A., additional, Li, M., additional, Weiss, J., additional, Rosen, J., additional, Pal, P., additional, Sherpherd, F., additional, Lok, B., additional, Moghal, N., additional, Liu, G., additional, and Tsao, M.S., additional

Published
2023
Full Text
View/download PDF

3. EP07.02-15 Longitudinal ctDNA Testing in Resected, Early Stage Non-small Cell Lung Cancers

Author

Feng, J., primary, Waddell, T., additional, Yasufuku, K., additional, Kelly, D., additional, Meti, N., additional, Pierre, A., additional, Keshavjee, S., additional, Yeung, J., additional, Cypel, M., additional, Donahoe, L., additional, Wakeam, E., additional, de Perrot, M., additional, Law, J., additional, Salvarrey, A., additional, Le, L.W., additional, Lister, J., additional, Cabanero, M., additional, Tsao, M.S., additional, Pipinikas, C., additional, Howarth, K., additional, and Leighl, N.B., additional

Published
2023
Full Text
View/download PDF

5. EP07.01-018 Phase III Randomized Trial on Surgery, Chemo and Pleural Radiation (IMPRINT) for Resectable Pleural Mesothelioma (NRG LU-006)

Author

Rimner, A., primary, Hu, C., additional, Simone, C.B., additional, Rusch, V.W., additional, Zauderer, M.G., additional, Gill, R.R., additional, Yorke, E.D., additional, Li, Z., additional, Voong, K.R., additional, Peikert, T., additional, Tsao, M.S., additional, Paulus, R., additional, and Bradley, J.D., additional

Published
2022
Full Text
View/download PDF

6. EP11.02-001 Natural Language Processing to Abstract Preneoplastic and Incidental Pulmonary Lesions from Pathology Reports

Author

Petricca, J., primary, French, C., additional, Ajaj, R., additional, Zelifan, A., additional, Grant, B., additional, Zhan, L., additional, Zhang, Y., additional, Thakral, A., additional, Nicholls, D., additional, Hsu, Y.-H.R., additional, Pal, P., additional, Cabanero, M., additional, Tsao, M.S., additional, and Liu, G., additional

Published
2022
Full Text
View/download PDF

9. 181P Poor response to PD-1 inhibitors in metastatic non-small cell lung cancer (mNSCLC) patients with liver metastases may be mediated by myeloid populations

Author

Makarem, M., primary, Lau, S.C., additional, Elliott, M.J., additional, Rabinovitch, A., additional, Kuang, S., additional, Schmid, S., additional, Tsao, M.S., additional, McGaha, T., additional, Ohashi, P., additional, Shepherd, F.A., additional, Bradbury, P., additional, Liu, G., additional, Leighl, N.B., additional, and Sacher, A., additional

Published
2021
Full Text
View/download PDF

10. 1809P Evaluation of KRAS mutation subtype on survival in patients with metastatic non-small cell lung cancer receiving immunotherapy

Author

Barron, C.C., primary, Kuang, S., additional, Makarem, M., additional, Elliott, M.J., additional, Sharma, K., additional, Lee, J., additional, Schmid, S., additional, Rabinovitch, A., additional, Bradbury, P., additional, Liu, G., additional, Shepherd, F.A., additional, Tsao, M.S., additional, Leighl, N., additional, Rose, A., additional, Pezo, R., additional, Doherty, M., additional, Cheng, S., additional, Lau, S.C., additional, and Sacher, A., additional

Published
2021
Full Text
View/download PDF

11. 1298P PD-1 inhibitors combined with chemotherapy may preferentially improve survival in metastatic NSCLC with myeloid-mediated primary resistance to immunotherapy

Author

Lau, S.C., primary, Elliott, M.J., additional, Rabinovitch, A., additional, Makarem, M., additional, Kuang, S., additional, Schmid, S., additional, Sharma, K., additional, Lee, J., additional, Mackay, K.M., additional, Wong, S.W., additional, Wang, B.X., additional, Ohashi, P.S., additional, Tsao, M.S., additional, Shepherd, F.A., additional, Bradbury, P., additional, Liu, G., additional, Leighl, N., additional, McGaha, T., additional, and Sacher, A., additional

Published
2021
Full Text
View/download PDF

12. Tumours of the lung : introduction

Author

Tsao, M.S., Asamura, H., Borczuk, A.C., Dacic, S., Devesa, S.S., Kerr, K.M., MacMahon, H., Rusch, V.W., Samet, J.M., Scagliotti, G.V, Travis, W.D, van Schil, Paul, Yatabe, Y., and Znaor, A.

Subjects
Human medicine
Published
2021

14. Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci

Author

Dai, J., Li, Z., Amos, C.I., Hung, R.J., Tardon, A., Andrew, A.S., Chen, C, Christiani, D.C., Albanes, D., Heijden, E. van der, Duell, E.J., Rennert, G., McKay, J.D., Yuan, J.M., Field, J.K., Manjer, J., Grankvist, K., Marchand, L. Le, Teare, M.D., Schabath, M.B., Aldrich, M.C., Tsao, M.S., Lazarus, P., Lam, S., Bojesen, S.E., Arnold, S, Wu, X., Haugen, A., Janout, V., Johansson, M., Brhane, Y., Fernandez-Somoano, A., Kiemeney, B., Davies, M.P., Zienolddiny, S., Hu, Z, Shen, H., Dai, J., Li, Z., Amos, C.I., Hung, R.J., Tardon, A., Andrew, A.S., Chen, C, Christiani, D.C., Albanes, D., Heijden, E. van der, Duell, E.J., Rennert, G., McKay, J.D., Yuan, J.M., Field, J.K., Manjer, J., Grankvist, K., Marchand, L. Le, Teare, M.D., Schabath, M.B., Aldrich, M.C., Tsao, M.S., Lazarus, P., Lam, S., Bojesen, S.E., Arnold, S, Wu, X., Haugen, A., Janout, V., Johansson, M., Brhane, Y., Fernandez-Somoano, A., Kiemeney, B., Davies, M.P., Zienolddiny, S., Hu, Z, and Shen, H.

Abstract

Item does not contain fulltext, DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 20 871 lung cancer cases and 15 971 controls to evaluate the associations between regulatory genetic variants in DHS and lung cancer susceptibility. The expression quantitative trait loci (eQTL) analysis and pathway-enrichment analysis were performed to identify the possible target genes and pathways. In addition, we performed motif-based analysis to explore the lung-cancer-related motifs using sequence kernel association test. Two novel variants, rs186332 in 20q13.3 (C>T, odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.10-1.24, P = 8.45 x 10-7) and rs4839323 in 1p13.2 (T>C, OR = 0.92, 95% CI: 0.89-0.95, P = 1.02 x 10-6) showed significant association with lung cancer risk. The eQTL analysis suggested that these two SNPs might regulate the expression of MRGBP and SLC16A1, respectively. What's more, the expression of both MRGBP and SLC16A1 was aberrantly elevated in lung tumor tissues. The motif-based analysis identified 10 motifs related to the risk of lung cancer (P < 1.71 x 10-4). Our findings suggested that variants in DHS might modify lung cancer susceptibility through regulating the expression of surrounding genes. This study provided us a deeper insight into the roles of DHS-related genetic variants for lung cancer.

Published
2019

15. Crizotinib Inhibition of ROS1-Positive Tumours in Advanced Non-Small-Cell Lung Cancer: A Canadian Perspective

Author

Bebb, D.G., primary, Agulnik, J., additional, Albadine, R., additional, Banerji, S., additional, Bigras, G., additional, Butts, C., additional, Couture, C., additional, Cutz, J.C., additional, Desmeules, P., additional, Ionescu, D.N., additional, Leighl, N.B., additional, Melosky, B., additional, Morzycki, W., additional, Rashid-Kolvear, F., additional, Sekhon, H.S., additional, Smith, A.C., additional, Stockley, T.L., additional, Torlakovic, E., additional, Xu, Z., additional, and Tsao, M.S., additional

Published
2019
Full Text
View/download PDF

16. Canadian Consensus: Oligoprogressive, Pseudoprogressive, and Oligometastatic Non-Small-Cell Lung Cancer

Author

Laurie, S.A., primary, Banerji, S., additional, Blais, N., additional, Brule, S., additional, Cheema, P.K., additional, Cheung, P., additional, Daaboul, N., additional, Hao, D., additional, Hirsh, V., additional, Juergens, R., additional, Laskin, J., additional, Leighl, N., additional, MacRae, R., additional, Nicholas, G., additional, Roberge, D., additional, Rothenstein, J., additional, Stewart, D.J., additional, and Tsao, M.S., additional

Published
2019
Full Text
View/download PDF

17. Canadian Perspectives: Update on Inhibition of ALK-Positive Tumours in Advanced Non-Small-Cell Lung Cancer

Author

Melosky, B., primary, Cheema, P., additional, Agulnik, J., additional, Albadine, R., additional, Bebb, D.G., additional, Blais, N., additional, Burkes, R., additional, Butts, C., additional, Card, P.B., additional, Chan, A.M.Y., additional, Hirsh, V., additional, Ionescu, D.N., additional, Juergens, R., additional, Morzycki, W., additional, Poonja, Z., additional, Sangha, R., additional, Tehfe, M., additional, Tsao, M.S., additional, Vincent, M., additional, Xu, Z., additional, and Liu, G., additional

Published
2018
Full Text
View/download PDF

18. New Insights on Diagnostic Reproducibility of Biphasic Mesotheliomas: A Multi-Institutional Evaluation by the International Mesothelioma Panel From the MESOPATH Reference Center

Author

Galateau Salle, F., primary, Le Stang, N., additional, Nicholson, A.G., additional, Pissaloux, D., additional, Churg, A., additional, Klebe, S., additional, Roggli, V.L., additional, Tazelaar, H.D., additional, Vignaud, J.M., additional, Attanoos, R., additional, Beasley, M.B., additional, Begueret, H., additional, Capron, F., additional, Chirieac, L., additional, Copin, M.C., additional, Dacic, S., additional, Danel, C., additional, Foulet-Roge, A., additional, Gibbs, A., additional, Giusiano-Courcambeck, S., additional, Hiroshima, K., additional, Hofman, V., additional, Husain, A.N., additional, Kerr, K., additional, Marchevsky, A., additional, Nabeshima, K., additional, Picquenot, J.M., additional, Rouquette, I., additional, Sagan, C., additional, Sauter, J.L., additional, Thivolet, F., additional, Travis, W.D., additional, Tsao, M.S., additional, Weynand, B., additional, Damiola, F., additional, Scherpereel, A., additional, Pairon, J.C., additional, Lantuejoul, S., additional, Rusch, V., additional, and Girard, N., additional

Published
2018
Full Text
View/download PDF

20. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

Author

Carreras-Torres, R., Johansson, M., Haycock, P.C., Wade, K.H., Relton, C.L., Martin, R.M., Smith, G., Albanes, D., Aldrich, M.C., Andrew, A., Arnold, S.M., Bickeboller, H., Bojesen, S.E., Brunnstrom, H., Manjer, J., Bruske, I., Caporaso, N.E., Chen, C., Christiani, D.C., Christian, W.J., Doherty, J.A., Duell, E.J., Field, J.K., Davies, M.P., Marcus, M.W., Goodman, G.E., Grankvist, K., Haugen, A., Hong, Y.C., Kiemeney, L.A.L.M., Heijden, E. van der, Kraft, P., Johansson, M.B., Lam, S., Landi, M.T., Lazarus, P., Marchand, L. Le, Liu, G., Melander, O., Park, S.L., Rennert, G., Risch, A., Haura, E.B., Scelo, G., Zaridze, D., Mukeriya, A., Savic, M., Lissowska, J., Swiatkowska, B., Janout, V., Holcatova, I., Mates, D., Schabath, M.B., Shen, H., Tardon, A., Teare, M.D., Woll, P., Tsao, M.S., Wu, X., Yuan, J.M., Hung, R.J., Amos, C.I., McKay, J., Brennan, P., Carreras-Torres, R., Johansson, M., Haycock, P.C., Wade, K.H., Relton, C.L., Martin, R.M., Smith, G., Albanes, D., Aldrich, M.C., Andrew, A., Arnold, S.M., Bickeboller, H., Bojesen, S.E., Brunnstrom, H., Manjer, J., Bruske, I., Caporaso, N.E., Chen, C., Christiani, D.C., Christian, W.J., Doherty, J.A., Duell, E.J., Field, J.K., Davies, M.P., Marcus, M.W., Goodman, G.E., Grankvist, K., Haugen, A., Hong, Y.C., Kiemeney, L.A.L.M., Heijden, E. van der, Kraft, P., Johansson, M.B., Lam, S., Landi, M.T., Lazarus, P., Marchand, L. Le, Liu, G., Melander, O., Park, S.L., Rennert, G., Risch, A., Haura, E.B., Scelo, G., Zaridze, D., Mukeriya, A., Savic, M., Lissowska, J., Swiatkowska, B., Janout, V., Holcatova, I., Mates, D., Schabath, M.B., Shen, H., Tardon, A., Teare, M.D., Woll, P., Tsao, M.S., Wu, X., Yuan, J.M., Hung, R.J., Amos, C.I., McKay, J., and Brennan, P.

Abstract

Contains fulltext : 174154.pdf (publisher's version ) (Open Access), BACKGROUND: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. METHODS AND FINDINGS: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01-1.43] and for small cell lung cancer (OR [95%CI] = 1.52 [1.15-2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m2]), but not for adenocarcinoma (OR [95%CI] = 0.93 [0.79-1.08]) (Pheterogeneity = 4.3x10-3). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10-3), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95%CI] = 0.90 [0.84-0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95%CI] = 1.63 [1.25-2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results. CONCLUSIONS: Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized

Published
2017

21. Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium

Author

Wang, T., Moon, J., Wu, Y., Amos, C.I., Tardon, A., Chen, C., Christiani, D.C., Albanes, D., Heijden, E. van der, Duell, E.J., Rennert, G., Liu, G., Yuan, J.M., Field, J.K., Manjer, J., Grankvist, K., Kiemeney, L.A., Marchand, L.L., Teare, M.D., Schabath, M.B., Johansson, M., Aldrich, M.C., Davies, M., Johansson, Mikael, Tsao, M.S., Caporaso, N., Lazarus, P., Bojesen, S.E., Arnold, S, Wu, X., Zong, X., Hong, Y.C., Ho, G.Y.F., Wang, T., Moon, J., Wu, Y., Amos, C.I., Tardon, A., Chen, C., Christiani, D.C., Albanes, D., Heijden, E. van der, Duell, E.J., Rennert, G., Liu, G., Yuan, J.M., Field, J.K., Manjer, J., Grankvist, K., Kiemeney, L.A., Marchand, L.L., Teare, M.D., Schabath, M.B., Johansson, M., Aldrich, M.C., Davies, M., Johansson, Mikael, Tsao, M.S., Caporaso, N., Lazarus, P., Bojesen, S.E., Arnold, S, Wu, X., Zong, X., Hong, Y.C., and Ho, G.Y.F.

Abstract

Contains fulltext : 180810.pdf (publisher's version ) (Open Access)

Published
2017

22. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Author

McKay, J.D., Hung, R.J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D.C., Caporaso, N., Johansson, M., Li, Y., Byun, J.Y., Dunning, A., Pooley, K.A., Qian, D.C., Liu, G., Bojesen, S.E., Wu, X., Marchand, L. le, Albanes, D., Bickeböller, H., Aldrich, M.C., Bush, W.S., Tardon, A., Rennert, G., Teare, M.D., Field, J.K., Kiemeney, L.A., Lazarus, P., Haugen, A., Schabath, M.B., Andrew, A.S., Shen, H., Hong, Y.C., Yuan, J.M., Bertazzi, P.A., Pesatori, A.C., Ye, Y., Diao, N., Su, L., Zhang, R., Brhane, Y., Leighl, N., Johansen, J.S., Mellemgaard, A., Saliba, W., Haiman, C.A., Wilkens, L.R., Fernandez-Somoano, A., Fernandez-Tardon, G., Heijden, H.F.M. van der, Kim, J.H., Hu, Z, Davies, M., Brunnström, H., Manjer, J., Melander, O., Muller, D., Overvad, K., Trichopoulou, A., Tumino, R., Doherty, J.A., Barnett, M.P., Chen, C., Goodman, G.E., Cox, A, Taylor, F., Woll, P.J., Brüske, I., Wichmann, H.E., Manz, J., Muley, T.R., Risch, A., Rosenberger, A., Grankvist, K., Shepherd, F.A., Tsao, M.S., Haura, E.B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T.M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Zienolddiny, S., Duell, E.J., Butler, L.M., Koh, W.P., Gao, Y.T., Houlston, R.S., McLaughlin, J., Stevens, V.L., Joubert, P., Lamontagne, M., Nickle, D.C., Obeidat, M., Timens, W., Zhu, B, Kachuri, L., Artigas, M.S., Tobin, M.D., Wain, L.V., Rafnar, T., Thorgeirsson, T.E., Reginsson, G.W., Stefansson, K., Hancock, D.B., Bierut, L.J., Spitz, M.R., Gaddis, N.C., Lutz, S.M., Kamal, A., Pikielny, C., Zhu, D., Lindströem, S., Jiang, X., Tyndale, R.F., Chenevix-Trench, G., Beesley, J., Bossé, Y., Chanock, S., Brennan, P., Landi, M.T., Amos, C.I., McKay, J.D., Hung, R.J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D.C., Caporaso, N., Johansson, M., Li, Y., Byun, J.Y., Dunning, A., Pooley, K.A., Qian, D.C., Liu, G., Bojesen, S.E., Wu, X., Marchand, L. le, Albanes, D., Bickeböller, H., Aldrich, M.C., Bush, W.S., Tardon, A., Rennert, G., Teare, M.D., Field, J.K., Kiemeney, L.A., Lazarus, P., Haugen, A., Schabath, M.B., Andrew, A.S., Shen, H., Hong, Y.C., Yuan, J.M., Bertazzi, P.A., Pesatori, A.C., Ye, Y., Diao, N., Su, L., Zhang, R., Brhane, Y., Leighl, N., Johansen, J.S., Mellemgaard, A., Saliba, W., Haiman, C.A., Wilkens, L.R., Fernandez-Somoano, A., Fernandez-Tardon, G., Heijden, H.F.M. van der, Kim, J.H., Hu, Z, Davies, M., Brunnström, H., Manjer, J., Melander, O., Muller, D., Overvad, K., Trichopoulou, A., Tumino, R., Doherty, J.A., Barnett, M.P., Chen, C., Goodman, G.E., Cox, A, Taylor, F., Woll, P.J., Brüske, I., Wichmann, H.E., Manz, J., Muley, T.R., Risch, A., Rosenberger, A., Grankvist, K., Shepherd, F.A., Tsao, M.S., Haura, E.B., Bolca, C., Holcatova, I., Janout, V., Kontic, M., Lissowska, J., Mukeria, A., Ognjanovic, S., Orlowski, T.M., Scelo, G., Swiatkowska, B., Zaridze, D., Bakke, P., Skaug, V., Zienolddiny, S., Duell, E.J., Butler, L.M., Koh, W.P., Gao, Y.T., Houlston, R.S., McLaughlin, J., Stevens, V.L., Joubert, P., Lamontagne, M., Nickle, D.C., Obeidat, M., Timens, W., Zhu, B, Kachuri, L., Artigas, M.S., Tobin, M.D., Wain, L.V., Rafnar, T., Thorgeirsson, T.E., Reginsson, G.W., Stefansson, K., Hancock, D.B., Bierut, L.J., Spitz, M.R., Gaddis, N.C., Lutz, S.M., Kamal, A., Pikielny, C., Zhu, D., Lindströem, S., Jiang, X., Tyndale, R.F., Chenevix-Trench, G., Beesley, J., Bossé, Y., Chanock, S., Brennan, P., Landi, M.T., and Amos, C.I.

Abstract

Contains fulltext : 177377.pdf (Publisher’s version ) (Closed access)

Published
2017

24. Improving Molecular Testing and Personalized Medicine in Non-Small-Cell Lung Cancer in Ontario

Author

Lim, C., primary, Sekhon, H.S., additional, Cutz, J.C., additional, Hwang, D.M., additional, Kamel-Reid, S., additional, Carter, R.F., additional, Santos, G. da Cunha, additional, Waddell, T., additional, Binnie, M., additional, Patel, M., additional, Paul, N., additional, Chung, T., additional, Brade, A., additional, El-Maraghi, R., additional, Sit, C., additional, Tsao, M.S., additional, and Leighl, N.B., additional

Published
2017
Full Text
View/download PDF

26. Computer Vision Tool and Technician as First Reader of Lung Cancer Screening CT Scans

Author

Ritchie, A.J., Sanghera, C., Jacobs, C., Zhang, W., Mayo, J., Schmidt, H., Gingras, M., Pasian, S., Stewart, L., Tsai, S., Manos, D., Seely, J.M., Burrowes, P., Bhatia, R., Atkar-Khattra, S., Ginneken, B. van, Tammemagi, M., Tsao, M.S., Lam, S., et al., Ritchie, A.J., Sanghera, C., Jacobs, C., Zhang, W., Mayo, J., Schmidt, H., Gingras, M., Pasian, S., Stewart, L., Tsai, S., Manos, D., Seely, J.M., Burrowes, P., Bhatia, R., Atkar-Khattra, S., Ginneken, B. van, Tammemagi, M., Tsao, M.S., Lam, S., and et al.

Abstract

Contains fulltext : 172195.pdf (Publisher’s version ) (Open Access), To implement a cost-effective low-dose computed tomography (LDCT) lung cancer screening program at the population level, accurate and efficient interpretation of a large volume of LDCT scans is needed. The objective of this study was to evaluate a workflow strategy to identify abnormal LDCT scans in which a technician assisted by computer vision (CV) software acts as a first reader with the aim to improve speed, consistency, and quality of scan interpretation.Without knowledge of the diagnosis, a technician reviewed 828 randomly batched scans (136 with lung cancers, 556 with benign nodules, and 136 without nodules) from the baseline Pan-Canadian Early Detection of Lung Cancer Study that had been annotated by the CV software CIRRUS Lung Screening (Diagnostic Image Analysis Group, Nijmegen, The Netherlands). The scans were classified as either normal (no nodules \geq1 mm or benign nodules) or abnormal (nodules or other abnormality). The results were compared with the diagnostic interpretation by Pan-Canadian Early Detection of Lung Cancer Study radiologists.The overall sensitivity and specificity of the technician in identifying an abnormal scan were 97.8\% (95\% confidence interval: 96.4-98.8) and 98.0\% (95\% confidence interval: 89.5-99.7), respectively. Of the 112 prevalent nodules that were found to be malignant in follow-up, 92.9\% were correctly identified by the technician plus CV compared with 84.8\% by the study radiologists. The average time taken by the technician to review a scan after CV processing was 208 ± 120 seconds.Prescreening CV software and a technician as first reader is a promising strategy for improving the consistency and quality of screening interpretation of LDCT scans.

Published
2016

27. Canadian Consensus: Inhibition of Alk-Positive Tumours in Advanced Non-Small-Cell Lung Cancer

Author

Melosky, B., primary, Agulnik, J., additional, Albadine, R., additional, Banerji, S., additional, Bebb, D.G., additional, Bethune, D., additional, Blais, N., additional, Butts, C., additional, Cheema, P., additional, Cheung, P., additional, Cohen, V., additional, Deschenes, J., additional, Ionescu, D.N., additional, Juergens, R., additional, Kamel-Reid, S., additional, Laurie, S.A., additional, Liu, G., additional, Morzycki, W., additional, Tsao, M.S., additional, Xu, Z., additional, and Hirsh, V., additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results