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1. The association between bone density of lumbar spines and different daily protein intake in different renal function.

Author

Lee, Chia-Lin, Chen, Kun-Hui, Liu, Wei-Ju, Chen, Ching-Hsien, and Tsai, Shang-Feng

Subjects
Bone density, chronic kidney disease, lumbar spine, osteoporosis, protein diet, Humans, Bone Density, Nutrition Surveys, Osteoporosis, Kidney, Renal Insufficiency, Chronic, Dietary Proteins
Abstract

BACKGROUND: Low protein intake (LPI) has been suggested as a treatment for chronic kidney disease (CKD). However, protein intake is essential for bone health. METHODS: We studied the database of the National Health and Nutrition Examination Survey, 2005-2010. Basic variables, metabolic diseases, and bone density of different femoral areas were stratified into four subgroups according to different protein intake (DPI) (that is, 1.2 g/kg/day). RESULTS: Significant differences were found among all lumbar area bone mineral density (BMD) and T-scores (p 1.2 g/day/kg over L2 (relative risk (RR)=1.326, 95% confidence interval (CI)=1.062-1.656), subgroup >1.2 g/day/kg over L3 (RR = 1.31, 95%CI = 1.057-1.622), subgroup 1.2 g/day/kg over all L spines (RR = 0.333, 95%CI = 1.098-1.618). However, a higher risk of osteoporosis was observed only in the non-CKD group. There was an apparent trend of higher DPI coexisting with lower BMD and T scores in patients with CKD. For osteoporosis (reference:0.8-1.0 g/day/kg), lower (1.2 g/day/kg) was associated with higher risks in the non-CKD group, but not in the CKD group. CONCLUSIONS: In the CKD group, LPI for renal protection was safe without threatening L spine bone density and without causing a higher risk of osteoporosis.

Published
2024

8. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

Author

Abbasciano, Isabella, Abrantes, Catarina, Accarino, Simone, Adler, Sharon, Adoberg, Annika, Afsari, Rouzbeh, Ahmad, Syeda, Ahmed, Jafar, Ahn, Wooin, Ajayi, Bamidele, Aksamit, Dariusz, Al Chalabi, Saif, Alamartine, Eric, Alchi, Bassam, Ali, Mohammad, Aliotta, Roberta, Almaani, Salem, Almeida, Catarina, Almeida, Edgar, Alvarez, Francisco de la Prada, Alves, Patricia, Annese, Francesca, Appel, Gerald, Arduan, Alberto Ortiz, Arena, Maria, Arevalo, Marta Calvo, Arfaania, Dariush, Arias, Carlos, Aristoy, Emma Calatayud, Asakiene, Egle, Ashley, Sarah, Assefi, Ali, Atenza, Alba, Auerbach, Asta, Augustyniak-Bartosik, Hanna, Avella, Monroy, Ayling-Smith, Jonathan, Ayoub, Isabelle, Ayvazyan, Christine, Baccaro, Rocco, Bailey, Asha, Baker, Bruce, Balamuthusamy, Saravanan, Ballarin, Jose, Barata, Rui, Barbic, Jerko, Barisic, Dunja, Barratt, Jonathan, Barreto, Jose Carlos de Jesus, Barrios, Clara, Belingheri, Mirco, Benesova, Anna, Bernabeu, Ana Avila, Bernhardt, Wanja, Bhadra, Shamik, Biancone, Luigi, Blanchard, Anne, Boaglio, Elena, Bolignano, Davide, Bomback, Andrew, Bonilla, Gustavo Andres Useche, Bordoli, Monica, Bose, Bhadran, Boudville, Neil, Brandon, Donald, Brown, Karen, Broyet, Christian, Bucknall, Thomas, Buffet, Alexandre, Bumblyte', Inga Arune, Burdese, Manuel, Burgos, Natalia Allende, Burguet, Laure, Burtey, Stephane, Busch, Martin, Cakiroglu, Figen, Campbell, Victoria, Canetta, Pietro, Capaccio, Flavia, Carbonell, Juan, Cardoso, Filipa, Carro, Clara Garcia, Carroll, Robert, Carron, Pierre-Louis, Carullo, Nazareno, Cassia, Matthias, Caster, Dawn, Castillo, Belen Vizcaino, Catucci, Davide, Cavalli, Andrea, Chae, Dong-Wan, Chakera, Aron, Chan, Doris, Chan, Gary Chi Wang, Chan, Anthony Ting Pong, Chan, Lai Wan, Chang, Jae Hyun, Chang, Ming-Shan, Chapman, Fiona, Charytan, Chaim, Chaudhry, Asghar, Cheetham, Melissa, Chen, Cheng-Hsu, Chen, Hsin-Yu, Chen, Chien-Liang, Chen, Hung-Yuan, Chen, Hung-Chun, Chenine, Leila, Cheung, Siu Fai, Cheung, Chee Kay, Chiche-Jourde, Noemie, Chiu, Hsien-Fu, Chiu, Yen-Ling, Chiu, Yi-Wen, Chiu, Ian, Choi, Hoon Young, Chou, Kang-Ju, Chowdhury, Paramit, Chowdhury, Pradip, Chrysochou, Constantina, Chukwu, Chukwuma, Chun, Ka Yeong, Chung, Wookyung, Cieniawski, Dominik, Claisse, Guillaume, Clayton, Philip, Cleary, Catalina Martín, Clement, Nisha, Coates, Toby, Cogno, Chiara, Colla, Loredana, Collins, Michael, Colucci, Marco, Combe, Christian, Comi, Nicolino, Comunale, Roderick, Contreras, Gabriel, Cooper, Bruce, Coppock, Gaia, Costa, Ana Cortesão, Costanzi, Stefano, Cozzolino, Mario, Crail, Susan, Cunha, Liliana, Curry, Elizabeth, Dai, Tiane, Daina, Erica, Daneshvari, Sam, Dasgupta, Indranil, DaSilva, Louise, Davidson, Robert, De Bhailis, Aine Maire, de Précigout, Valérie, Decupere, Marc, Delmas, Yahsou, Deodato, Francesca, Dhaun, Neeraj, Dhaygude, Ajay, Dhelaria, Ranjit, Di Maio, Federica, Diezhandino, Maria Angeles Goicoechea, Dika, Zivka, Dinic, Miriana, Dittmer, Ian, Dobre, Mirela, Doctor, Gabriel, Donati, Gabriele, Doubel, Peter, Douthit, Nicole, Draganova, Diliana, Drexler, Yelena, Drinkovic, Martin, Drinovska, Klara, Dudreuilh, Caroline, Dumond, Clement, Durlen, Ivan, Dussol, Bertrand, Encarnacion, Montserrat Diaz, Endre, Zoltan, Enrique, Jorge, Eqbal, Yusuf, Erlich, Jonathan, Esposito, Vittoria, Esposito, Ciro, Fakih, Faisal, Fang, Hua-Chang, Farinha, Ana, Fearday, Aaron, Felgueiras, Joana de Sousa Soares, Felicjanczuk, Elzbieta, Fernandes, João Carlos, Fernandes, Sara, Fernandes, Adriana, Fernandez, Jose Luño, Fernandez, Victor, Fernando, Mangalee, Figueiredo, Ana Carolina, Firre, Eric, Floege, Jürgen, Flossmann, Oliver, Floyd, Lauren, Fonseca, Nuno, Fonseca, Jose Nuno de Almeida Agapito, Foote, Celine, Forbes, Suzanne, Forcen, Angel, Fornoni, Alessia, Fouassier, David, Fraser, Ian, Fung, Ka Shun Samuel, Furlano, Monica, Furtado, Teresa, Gadh, Rajdeep, Gaisset, Roxane, Gallagher, Martin, Gameiro, Joana, Gangadharan, Muralikrishna, Garcia, Fabiola Alonso, Garcia, Olga Gracia, Garg, Gunjan, Garrouste, Cyril, Gautam, Archana, Geara, Abdallah, Geddes, Colin, Gellineo, Lana, Germain, Michael, Gesualdo, Loreto, Ghalli, Farid, Giaroni, Francesco, Giles, Harold, Gillies, Alastair, Gimeno, Ana Vilar, Girardet, Annette, Glaze, Jeffrey, Goh, Tze, Gois, Mario, Goldsmith, Christopher, Goma, Elena, Gomes, Ana Marta, Goncalves, Luis Pedro Falcao, Goncalves, Sara, Gontarek-Kacprzak, Julita, Gonzalez, Carlos, Gopu, Arun, Gowda, Nayan, Gray, Nicholas, Greco, Barbara, Green, Heather, Greze, Clarisse, Griffin, Sian, Guldris, Secundino Cigarran, Guzman, Ursula Verdalles, Ha, Jeffrey Tsun Kit, Hall, Amanda, Hamilton, Patrick, Han, Seung Hyeok, Haws, Robert, Hayat, Ashik, Heath, Lauren, Heinrichs, Sven, Henderson, Andrew, Henderson, Amy, Hendren, Elizabeth, Heng, Anne-Elisabeth, Heres, Salia Virxinia Pol, Herfurth, Johann Konstantin, Herrero, Evangelina Merida, Ho, Tzung-Yo, Hogan, Jonathan, Hohenstein, Bernd, Hollett, Peter, Horvatic, Ivica, Hsu, Bang-Gee, Hsu, Chia-Tien, Hsu, Chih-Yang, Hsu, Shih-Ping, Huang, Chien-Wei, Hudson, Amy, Hung, Chi-Chih, Hwang, Shang-Jyh, Hwang, Daw-Yang, Hyun, Young Youl, Ilmoja, Madis, Irish, Georgina, Jacob, Radu, Jahan, Sadia, Jain, Arunima, Jamar, Sofie, Jander, Anna, Jang, Hye Ryoun, Janko, Catherine, Jardine, Meg, Jaskowski, Piotr, Jeantet, Guillaume, Jelakovic, Bojan, Jeon, Junseok, Jeong, Jong Cheol, Jesudason, Shilpanjali, Jittirat, Arksarapuk, Jo, Sang-Kyung, Jones, Rachel, Joo, Narae, Jorge, Sofia, Julian, Bruce, Jung, JiYong, Jyothinagaram, Praveena, Kadakia, Jigar, Kamal, Fahameedah, Kanigicherla, Durga, Karanovic, Sandra, Karras, Alexandre, Kasimatis, Theodoros, Kassem, Mohamad, Kattamanchi, Siddhartha, Keller, Christopher, Kentric, Dubravka Trajbar, Kettner, Christiane, Khalil, Kassem, Kim, Dana, Kim, Se Joong, Kim, Yeong Hoon, Kim, Yunmi, Kim, Hyung Wook, Kim, Sunggyun, Kim, Jwa-Kyung, Kim, Aejin, Kim, Myung-Gyu, Kimber, Cassandra, Klamm, Kathryn, Koch, Annegret, Koester, Eric, Kolvald, Kulli, Kon, Sui, Kooienga, Laura Ann, Kotwal, Sradha, Krajewska, Magdalena, Kratka, Karolina, Krishnan, Anoushka, Krishnasamy, Rathika, Krueger, Thilo, Kruljac, Ivan, Kulka, Simone, Kunzendorf, Ulrich, Kuo, Mei-Chuan, Kuo, Hung-Tien, Kuo, Sheng, Kwan, Lorraine Pui Yuen, Kwella, Norbert, Kwella, Bogna, Kyaw, Kay, Labat, Aurore, Lafayette, Richard, Lagatta, Mark, Lam, Chi Kwan Darwin, Lambie, Mark, Lanaret, Camille, Latif, Farah, Laute, Margo, Law, Wai Ping, Lawman, Sarah, Lazo, Mercedes Salgueira, Lee, Hajeong, Lee, Moon Hyoung, Lee, Kyu-Beck, Lee, Hyung-seok, Lee, JungEun, Lee, Hyun Hee, Lee, Po-Tsang, Leis, Liisi, Lemahieu, Wim, Leung, Janson, Li, Yan, Lie, Davina Ngoi Wah, Lifland, Howard, Lilienthal, Kadri, Lim, Wai, Limardo, Monica, Livrozet, Marine, Longhi, Selena, Lopes, Daniela, Lopes, Jose Antonio, Lorde, Nathan, Luxton, Grant, Ma, Mingyao, Madhrira, Machaiah, Madonia, Phillip, Maes, Bart, Mahadevan, Kumaradevan, Mahdi, Amar, Mahdi, Eamon, Maillard, Nicolas, Maixnerova, Dita, Majstorovic Barac, Karolina, Malecki, Robert, Malfait, Thomas, Malvica, Silvia, Mandayam, Sreedhar, Manley, Paul, Mansfield, Nick, Marcantoni, Carmelita, Mariat, Christophe, Marin, Tamara Malek, Marin, Lida Maria Rodas, Mark, Patrick, Marques, Joana, Martinez, Eduardo Gutierrez, Martinez, Stacy, Masset, Catherine, Masson, Ingrid, Mather, Amanda, Maung Myint, Thida Maung, Mayet, Valentin, McCafferty, Kieran, McCarthy, Ellen, McDonald, Stephen, McGreal, Kerri, McMahon, Kellyn, McNally, Andrew, McQuarrie, Emily, Medina, Allyson, Meeus, Gert, Mehta, Kshama, Mendoza, Elder, Menezes, Maria, Meng, Jerry, Messa, Piergiorgio, Messias, Ana, Miarka, Przemyslaw, Miglinas, Marius, Mikacic, Ivana, Mikhail, Ashraf, Milicevic, Martina, Minasian, Raffi, Moeller, Marcus, Mohey, Hesham, Mojarrab, Javad, Mok, Maggie Ming Yee, Moncasi, Eduardo Parra, Moonen, Martial, Morales, Wenceslao Adrian Aguilera, Moreno, Eduardo Verde, Moreno, Antolina, Morris, Adam, Moutzouris, Dimitrios, Moya, Mercedes Gonzalez, Mucha, Simon, Musolino, Michela, Napodano, Pietro, Natario, Ana, Negrea, Lavinia, Nelson, Bradley, Neuen, Brendon, Newsome, Britt, Ng, Kit Chung Jack, Nguyen, Thu, Nguyen, Viet, Nicolo, Clementine, Nitschke, Martin, Noble, Euan, Nolasco, Fernando, O'Lone, Emma, Ochoa, Adriana Sierra, Oh, Kook-Hwan, Oh, SeWon, Okoh, Pedro, Ombelet, Sara, O'Shaughnessy, Michelle, Ou, Shih-Hsiang, Packham, David, Padiyar, Aparna, Pai, Mei-Fen, Pamplona, Irene Agraz, Pan, Szu-Yu, Pandya, Bhavna, Papadia, Federica, Pardinhas, Clara, Parikh, Nishita, Parikh, Samir, Park, Hyeong Cheon, Park, Jung Tak, Parreira, Lucia, Passerini, Patrizia, Patak, Ramachandra, Patecki, Margret, Patel, Rajan, Patel, Jusmin, Patel Suthar, Meera, Patella, Gemma, Patrikyan, Artashes, Pavlovic, Drasko, Paxton, William, Peh, Chen, Peleg, Yonatan, Pelicano, Josep Miquel Blasco, Peng, Yu-Sen, Pereira de Vicente, Manuel, Perez, Jonay Pantoja, Perez, Erika, Perez de Jose, Ana, Pérez Gómez, María Vanessa, Perez Lluna, Leticia, Peri, Usha, Perico, Norberto, Philipponnet, Carole, Phua, Elaine, Piel, Julia, Pillai, Unnikrishnan, Pilmore, Helen, Plavljanic, Djuro, Plaza, Mercedes Velo, Pollock, Carol, Ponnusamy, Arvind, Ponti, Serena, Powell, Thomas, Pradhan, Nishigandha, Prado, Raul Fernandez, Prkacin, Ingrid, Pruthi, Rishi, Pugh, Dan, Quinn, Sarah, Quintana, Luis F, Raakesh, Lathika, Rabindranath, Kannaiyan, Radermacher, Luc, Radhakrishnan, Jai, Ragy, Omar Sherin Ibrahim, Raichoudhury, Ritesh, Raimundo, Mario, Randone, Paolo, Razavian, Mona, Reichel, Helmut, Reis, Marina, Remuzzi, Giuseppe, Reynolds, Annie, Ricchiuto, Anna, Rico, Ivon Maritza Bobadilla, Rigothier, Claire, Ritchie, Angus, Rivero, Maria Antonieta Azancot, Rizk, Dana, Ro, Han, Rodriguez, Alfred, Rodriguez Garcia, Eva, Roger, Simon, Rony, Mohammad, Rosenberg, Mai, Roueff, Stephane, Rovin, Brad, Roxburgh, Sarah, Ruiz, Mario, Rusinol, Helena Marco, Rychlik, Ivan, Sá, Helena, Salehi, Tania, Sánchez de la Nieta, Maria Dolores, Sanden, Silja, Santockiene, Lina, Santos, Patricia Valerio, Santos, Iara Da Silva, Sargsyan, Mari, Sarnow, Franziska, Sat, Sebahat, Satora, Ewa, Savuk, Ana, Sayer, Matthew, Schlieper, Georg, Schlosser, Mandy, Schmidt-Guertler, Hans, Schockaert, Olivier, Schulte, Kevin, Schulz, Lisa, Selvaskandan, Haresh, Semple, David, Sen, Shaundeep, Seppet, Elviira, Serrano, Antonio Galan, Serre, Jean-Emmanuel, Sevillano, Angel, Shah, Sapna, Shen, Yvonne, Sheridan, Brittany, Shu, Kai-Hsiang, Sightler, Ford, Silva, Sónia, Silva, Arnold, Sinha, Smeeta, Siriwardana, Amanda, Sitas, Zvonimir, Sivo, Carmen, Sizeland, Peter, Sly, Cathylee, Smith, Priscilla, Snow, Brian, Soares, Elsa Sofia Quadrado, Solazzo, Andrea, Solis, Elena Gutierrez, Solomon, Laurence, Song, Young Rim, Sousa, Helena, Spinowitz, Bruce, Stallworthy, Elizabeth, Stamellou, Eleni, Stanczyk, Malgorzata, Stangenberg, Stefanie, Stankovic, Marija, Stankuviene, Asta, Stea, Emma Diletta, Stompor, Tomasz, Storrar, Joshua, Sullivan, James, Sulowicz, Wladyslaw, Suyumova, Irina, Szeto, Cheuk Chun, Tamarit, Esther, Tan, Eddie, Tan, May, Tang, Sydney Chi Wai, Tang, Hon, Teixeira, Catarina, Telling, Kadri, Terrades, Natalia Ramos, Tesar, Vladimir, Tez, Didem, Thervet, Eric, Thibaudin, Damien, Thomas, Mark, Thyagarajan, Nikhil, Tkaczyk, Marcin, Torreggiani, Massimo, Trillini, Matias, Tsai, Shang-Feng, Tsai, Wan-Chuan, Tsai, Jer-Chia, Tseng, Po-Yu, Tumlin, James, Tung, Kuei-Ting, Turnbull, Angus, Udani, Suneel, Uhlinova, Jana, Unt, Kristin, Urciuolo, Federica, Vanacker, An, Vandewiele, Bert, Vaz, Alvaro, Veermae, Kristi, Viaene, Liesbeth, Vickiene, Alvita, Vigano, Sara, Vila, Maria Antonia Munar, Vilayur, Eswari, Villanueva, Caridad Martinez, Villarroya, Cristina Medrano, Villen, Alejandro Soria, Viramontes, Veronica, Vita, Caterina, Vujcic, Dunja, Wahba, Mona, Wan, Susan, Wang, Chih-Hsien, Warling, Xavier, Waters, Gerald, Waugh, Jane, Weiland, Lea, Weiner, Stefan, Weinreich, Thomas, Werth, Stephan Christian, Wickens, Olivia, Wijeratne, Vidu, Wilder, Karen, Willcocks, Lisa, Williams, Allister, Winiarska, Agata, Wirtz, Nikolaus, Wolf, Lothar, Wolf, Gunter, Wong, Muh Geot, Wong, Yick Hei, Wong, Sze Ho Sunny, Workeneh, Biruh, Wu, Ming-Ju, Wu, Hon-Yen, Wyndham, Roger, Yang, Jihyun, Yang, Ju-Yeh, Yeap, Chii, Yim, Ka Fai, Yong, Kenneth, Yoo, Tae-Hyun, Yoon, Songuk, Yu, Tung-Min, Yue, Tak Tai Andrew, Zakari, Michel, Zakauskiene, Urte, Zaoui, Philippe, Zbrzezniak, Justyna, Zielinska, Dorota, Zizzi, Carlotta Federica, Rovin, Brad H, Heerspink, Hiddo J L, Alpers, Charles E, Bieler, Stewart, Diva, Ulysses A, Inrig, Jula K, Kohan, Donald E, Komers, Radko, Małecki, Robert, Mercer, Alex, Noronha, Irene L, Oh, Se Won, Peh, Chen Au, Praga, Manuel, Preciado, Priscila, Rheault, Michelle N, Rote, William E, Tang, Sydney C W, Trachtman, Howard, Trimarchi, Hernán, Tumlin, James A, and Perkovic, Vlado

Published
2023
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10. Comparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism

Author

Xinling, Liang, Shuangxin, Liu, Sijia, Li, Lixia, Xu, Zhiming, Ye, Zhonglin, Feng, Renwei, Huang, Zhilian, Li, Wei, Chen, Xunhua, Zheng, Naya, Huang, Zhen, Ai, Xin, Wang, former PI, Ni, Zhaohui, present PI, Renhua, Lu, Jianxiao, Shen, Yijun, Zhou, Xinghui, Lin, Yuanyuan, Xie, Jiahui, Zhang, Miaolin, Che, Yan, Fang, Huihua, Pang, Xinyu, Su, Leyi, Gu, Wei, Jin, Peipei, Zhao, Yiwei, Shen, Liou, Zao, Wei, Lu, Haidong, Huang, Gang, Ji, Hao, Li, Deguang, Wang, Liang, Yuan, Lihong, Ding, Xuerong, Wang, Huai, Li, Hong, Liu, Fang, Yuan, Panai, Song, An, Zhou, Xiaojun, Chen, Xiejia, Li, Liyu, He, Xia, Tan, Jing, Chen, Minmin, Zhang, Qian, Zhang, Jing, Qian, Yaozhong, Kong, Youyuan, Chen, Wei, Shen, Guanqing, Xiao, Dezhen, Chen, Dao, Li, Aizhen, Hou, Xiaolei, Li, Hanchang, He, Huizhen, Ye, Zhuxing, Sun, Xiran, Zhang, Weiwei, Shan, Jing, Xue, Yong, Chen, Changying, Xing, Li, Li, Xiangbao, Yu, Kang, Liu, Yifei, Ge, Yili, Xu, Zhimin, Huang, Jingjing, Wu, Bicheng, Liu, Yan, Tu, Mingming, Pan, Hongli, Lin, Dapeng, Wang, Qingyang, Meng, Renna, Luo, Guohua, Ding, Ming, Shi, Changjian, Qiu, Xifeng, Lv, Guojuan, Zhang, Liping, Jiang, Ning, Ding, Huiying, Zhao, Shumin, Bao, Shen, Chen, Qiaojing, Liang, Mei, Zhang, Kanfu, Peng, Pan, Xie, Qian, Yuan, Yan, Zhuo, Shaohua, Li, Yonghui, Mao, Ban, Zhao, Songlan, Wang, Xianguang, Chen, Xiaonong, Chen, Chenni, Gao, Haijin, Yu, Qinjie, Weng, Yuanmeng, Jin, Xiaobo, Ma, Ping, Luo, Dan, Gao, Man, Wu, Yonghui, Qi, Ping, Zhang, Xiaoying, Du, Lihui, Qu, Chunping, Xu, Kaixiang, Sheng, Yi, Yang, Song, Wang, Xinkui, Tian, Hongxia, Guo, Wenhan, Bao, Weifeng, Lin, Sijia, Zhou, Zhuan, Cui, Wenling, Yang, Kaijie, Su, Lian, He, Zhihong, Zhou, Yu, Zheng, Shubei, Zheng, Lingwei, Jin, Yan, Chen, Min, Pan, Wu, Chia-Chao, SungShuei-Liong Lin, Chih-Chien, Wu, Ming-Shiou, Huang, Jenq-Wen, Chiang, Wen Chih, Chiang, Chih-Kang, Yang, Shao-Yu, Wu, Vin-Cent, Huang, Tao-Min, Chen, Yi-Ting, Lai, Tai-Shuan, Lai, Chun-Fu, Tarng, Der-Cherng, Ou, Shuo-Ming, Yang, Chih-Yu, Tseng, Wei-Cheng, Lin, Yao-Ping, Sung, Junne-Ming, Kuo, Te-Hui, Chang, Yu-Tzu, Wu, An-Bang, Lin, Wei-Hung, Fang, Hua-Chang, Chen, Hsin-Yu, Hsu, Chih-Yang, Lee, Po-Tsang, Chen, Chien-Liang, Chou, Kang-Ju, Ho, Tzung-Yu, Lee, Chien-Te, Ng, Hwee-Yeong, Lee, Yueh-Ting, Chiu, Yi-Wen, Kuo, Hung-Tien, Hung, Chi-Chih, Kuo, Mei-Chuan, Lee, Jia-Jung, Tsai, Jer-Chia, Chang, Jer-Ming, Lee-Moay, Lim, Hwang, Shang-Jyh, Hwang, Jyh-Chang, Wang, Hsien-Yi, Kan, Wei-Chih, Wu, Chia-Chun, Jiang, Ming-Yan, Chien, Chih-Chiang, Wu, Ming-Ju, Tsai, Shang-Feng, Chen, Cheng-Hsu, Chen, Hsi-Hsien, Kao, Chih-Chin, Lin, Yen-Chung, Wu, Yueh-Lin, Yeh, Shu-Ching, Mao Chan, Daniel Tak, Yee Mok, Maggie Ming, Yuen Kwan, Lorraine Pui, Wang Chan, Gary Chi, Kim, Yong-Lim, Cho, Jang-Hee, Lim, Jeong-Hoon, Jung, Hee-Yeon, Park, Sun-Hee, Kim, Chan-Duck, Kim, Kyu Yeun, Park, Jung Tak, Yoo, Tae-Hyun, Han, Seung Hyeok, Chung, Wookyung, Jung, Ji Yong, Lee, Hyun Hee, Chang, Jae Hyun, Ro, Han, Kim, Ae Jin, Lee, Jong Soo, Park, Jongha, Park, Kyung Sun, Yoo, Kyoung Don, Chang, Tae Ik, Kang, Ea Wha, Park, Kyoung Sook, Jin, Kyubok, Kim, Yaerim, Paek, Jinhyuk, Park, Wooyeong, Han, Seungyeup, Kwon, Ohyun, Park, Sung Bae, Kim, Myung-gyu, Oh, SeWon, Lee, Jung Pyo, Lee, Jeonghwan, Jung, Jihoon, Park, Cheol Whee, Kim, Hyung Duk, Kim, Sunggyun, Song, Youngrim, Joo, Narae, Lee, Hyungsuk, Choi, Bum-Soon, Park, Hoon Suk, Ban, Tae Hyun, Liang, Xinling, Lu, Kuo-Cheng, Chan, Tak Mao, Fukagawa, Masafumi, Kinoshita, Jun, Nagai, Chisato, Kojima, Masahiro, and Yu, Xueqing

Published
2023
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11. Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Author

Alarmartine, Eric, Barratt, Jonathan, Chae, Dong Wan, Del Vecchio, Lucia, Floege, Jurgen, Hwang, Shang-Jyh, Jelakovic, Bojan, Maes, Bart, Malecki, Robert, Miglinas, Marius, Nolasco, Fernando Eduardo Barbosa, Praga, Manual, Rabindranath, Kannaiyan, Rosenberg, Mai, Rovin, Brad, Tang, Sydney Chi Wai, Tesar, Vladmir, Wong, Muh Geot, Bose, Bhadran, Gangadharan, Muralikrishna, McDonald, Stephen, Peh, Chen, Jahan, Sadia, Yeap, Chii, Clayton, Philip, Irish, Georgina, Thyagarajan, Nikhil, Hollett, Peter, Krishnasamy, Rathika, Carroll, Robert, Jesudason, Shilpanjali, Crail, Susan, Coates, Toby, Waugh, Jane, Noble, Euan, Mahadevan, Kumaradevan, Campbell, Victoria, Salehi, Tania, Lim, Wai, Boudville, Neil, Chakera, Aron, Chan, Doris, Krishnan, Anoushka, Eqbal, Yusuf, Gillies, Alastair, Vilayur, Eswari, Maung Myint, Thida Maung, Gray, Nicholas, Cheetham, Melissa, Pollock, Carol, Cooper, Bruce, Mather, Amanda, Roxburgh, Sarah, Shen, Yvonne, Stangenberg, Stefanie, Siriwardana, Amanda, O'Lone, Emma, Wan, Susan, Neuen, Brendon, Tsun Kit Ha, Jeffrey, Kim, Dana, Heath, Lauren, Jain, Arunima, Phua, Elaine, Li, Yan, Gallagher, Martin, Jardine, Meg, Ritchie, Angus, Razavian, Mona, Foote, Celine, Wyndham, Roger, Sen, Shaundeep, Endre, Zoltan, Erlich, Jonathan, Fernando, Mangalee, Yong, Kenneth, Luxton, Grant, Kotwal, Sradha, Roger, Simon, Wijeratne, Vidu, Packham, David, Fraser, Ian, Vandewiele, Bert, Laute, Margo, Lemahieu, Wim, Jamar, Sofie, Ombelet, Sara, Meeus, Gert, Decupere, Marc, Schockaert, Olivier, Doubel, Peter, Viaene, Liesbeth, Radermacher, Luc, Masset, Catherine, Moonen, Martial, Firre, Eric, Milicevic, Martina, Warling, Xavier, Vanacker, An, Malfait, Thomas, Durlen, Ivan, Horvatic, Ivica, Savuk, Ana, Gellineo, Lana, Karanovic, Sandra, Dika, Zivka, Plavljanic, Djuro, Mikacic, Ivana, Trajbar Kentric, Dubravka, Barisic, Dunja, Stankovic, Marija, Majstorovic Barac, Karolina, Kruljac, Ivan, Pavlovic, Drasko, Drinkovic, Martin, Prkacin, Ingrid, Barbic, Jerko, Sitas, Zvonimir, Vujcic, Dunja, Rychlik, Ivan, Benesova, Anna, Drinovska, Klara, Kratka, Karolina, Maixnerova, Dita, Ilmoja, Madis, Unt, Kristin, Lilienthal, Kadri, Auerbach, Asta, Leis, Liisi, Piel, Julia, Adoberg, Annika, Kolvald, Kulli, Veermae, Kristi, Telling, Kadri, Seppet, Elviira, Uhlinova, Jana, Zaoui, Philippe, Carron, Pierre-Louis, Masson, Ingrid, Dinic, Miriana, Thibaudin, Damien, Broyet, Christian, Maillard, Nicolas, Mohey, Hesham, Mariat, Christophe, Claisse, Guillaume, Alamartine, Eric, Dussol, Bertrand, Burtey, Stephane, Chiche-Jourde, Noemie, Serre, Jean-Emmanuel, Jeantet, Guillaume, Chenine, Leila, Blanchard, Anne, Roueff, Stephane, Thervet, Eric, Fouassier, David, Buffet, Alexandre, Livrozet, Marine, Gaisset, Roxane, Karras, Alexandre, Heng, Anne-Elisabeth, Garrouste, Cyril, Philipponnet, Carole, Nicolo, Clementine, Atenza, Alba, Lanaret, Camille, Greze, Clarisse, Mayet, Valentin, Dumond, Clement, Delmas, Yahsou, Combe, Christian, Rigothier, Claire, Burguet, Laure, Labat, Aurore, Mucha, Simon, de Précigout, Valérie, Weinreich, Thomas, Reichel, Helmut, Draganova, Diliana, Wolf, Lothar, Hohenstein, Bernd, Heinrichs, Sven, Kulka, Simone, Sat, Sebahat, Weiland, Lea, Krueger, Thilo, Wolf, Gunter, Kettner, Christiane, Schlosser, Mandy, Herfurth, Johann Konstantin, Koch, Annegret, Busch, Martin, Werth, Stephan Christian, Nitschke, Martin, Cakiroglu, Figen, Sarnow, Franziska, Schulz, Lisa, Weiner, Stefan, Wirtz, Nikolaus, Koester, Eric, Moeller, Marcus, Stamellou, Eleni, Sanden, Silja, Schmidt-Guertler, Hans, Bernhardt, Wanja, Patecki, Margret, Schlieper, Georg, Schulte, Kevin, Girardet, Annette, Kunzendorf, Ulrich, Kwan, Lorraine Pui Yuen, Mok, Maggie Ming Yee, Chan, Gary Chi Wang, Ma, Mingyao, Lie, Davina Ngoi Wah, Chan, Anthony Ting Pong, Szeto, Cheuk Chun, Ng, Kit Chung Jack, Cheung, Siu Fai, Yue, Tak Tai Andrew, Fung, Ka Shun Samuel, Tang, Hon, Yim, Ka Fai, Law, Wai Ping, Wong, Yick Hei, Lam, Chi Kwan Darwin, Wong, Sze Ho Sunny, Marcantoni, Carmelita, Aliotta, Roberta, Deodato, Francesca, Patella, Gemma, Comi, Nicolino, Vita, Caterina, Carullo, Nazareno, Bolignano, Davide, Musolino, Michela, Trillini, Matias, Perico, Norberto, Remuzzi, Giuseppe, Daina, Erica, Biancone, Luigi, Colla, Loredana, Burdese, Manuel, Cogno, Chiara, Boaglio, Elena, Abbasciano, Isabella, Zizzi, Carlotta Federica, Randone, Paolo, Napodano, Pietro, Ricchiuto, Anna, Cassia, Matthias, Accarino, Simone, Cozzolino, Mario, Baccaro, Rocco, Costanzi, Stefano, Di Maio, Federica, Arena, Maria, Urciuolo, Federica, Vigano, Sara, Cavalli, Andrea, Limardo, Monica, Bordoli, Monica, Ponti, Serena, Longhi, Selena, Solazzo, Andrea, Giaroni, Francesco, Donati, Gabriele, Torreggiani, Massimo, Catucci, Davide, Colucci, Marco, Esposito, Vittoria, Esposito, Ciro, Gesualdo, Loreto, Capaccio, Flavia, Diletta Stea, Emma, Sivo, Carmen, Annese, Francesca, Papadia, Federica, Messa, Piergiorgio, Belingheri, Mirco, Passerini, Patrizia, Malvica, Silvia, Vickiene, Alvita, Zakauskiene, Urte, Asakiene, Egle, Bumblyte', Inga Arune, Stankuviene, Asta, Santockiene, Lina, Hayat, Ashik, Williams, Allister, Sizeland, Peter, Tan, Eddie, Waters, Gerald, Chan, Lai Wan, Henderson, Andrew, Turnbull, Angus, McNally, Andrew, Reynolds, Annie, Pilmore, Helen, Dittmer, Ian, Manley, Paul, Stallworthy, Elizabeth, Goh, Tze, Semple, David, Collins, Michael, Curry, Elizabeth, Ahmed, Jafar, Nguyen, Thu, Winiarska, Agata, Zbrzezniak, Justyna, Stompor, Tomasz, Krajewska, Magdalena, Augustyniak-Bartosik, Hanna, Zielinska, Dorota, Jander, Anna, Stanczyk, Malgorzata, Tkaczyk, Marcin, Miarka, Przemyslaw, Aksamit, Dariusz, Jaskowski, Piotr, Sulowicz, Wladyslaw, Cieniawski, Dominik, Gontarek-Kacprzak, Julita, Felicjanczuk, Elzbieta, Kwella, Norbert, Kwella, Bogna, Satora, Ewa, Fernandes, João Carlos, Gomes, Ana Marta, Reis, Marina, Lopes, Daniela, Almeida, Catarina, Sá, Helena, Figueiredo, Ana Carolina, Pardinhas, Clara, Almeida, Edgar, Raimundo, Mario, Cortesão Costa, Ana, Falcao Goncalves, Luis Pedro, Fernandes, Sara, Silva, Sónia, Teixeira, Catarina, Fernandes, Adriana, Nolasco, Fernando, Alves, Patricia, Gois, Mario, Fonseca, Nuno, Messias, Ana, Menezes, Maria, Cardoso, Filipa, Sousa, Helena, Marques, Joana, Barata, Rui, Lopes, Jose Antonio, Jorge, Sofia, Gameiro, Joana, de Almeida Agapito Fonseca, Jose Nuno, Goncalves, Sara, Farinha, Ana, Valerio Santos, Patricia, Natario, Ana, de Jesus Barreto, Jose Carlos, Abrantes, Catarina, Quadrado Soares, Elsa Sofia, Soares Felgueiras, Joana de Sousa, Cunha, Liliana, Parreira, Lucia, Furtado, Teresa, Vaz, Alvaro, Oh, Kook-Hwan, Lee, Hajeong, Joong Kim, Se, Jeong, Jong Cheol, Hoon Kim, Yeong, Kim, Yunmi, Park, Hyeong Cheon, Choi, Hoon Young, Wook Kim, Hyung, Lee, Moon Hyoung, Yoon, Songuk, Lee, Kyu-Beck, Hyun, YoungYoul, Yoo, Tae-Hyun, Han, Seung Hyeok, Park, Jung Tak, Kim, Sunggyun, Song, Young Rim, Kim, Jwa-Kyung, Lee, Hyung-seok, Joo, Narae, Lee, JungEun, Ryoun Jang, Hye, Jeon, Junseok, Chung, Wookyung, Lee, HyunHee, Chang, Jae Hyun, Chun, Ka Yeong, Jung, Ji Yong, Ro, Han, Kim, Aejin, Jo, Sang-Kyung, Yang, Jihyun, Kim, Myung-Gyu, Oh, SeWon, Martinez Villanueva, Caridad, Gimeno, Ana Vilar, Andres Useche Bonilla, Gustavo, Tamarit, Esther, Galan Serrano, Antonio, Verde Moreno, Eduardo, Fernandez, Jose Luño, Goicoechea Diezhandino, Maria Angeles, Verdalles Guzman, Ursula, de Jose, Ana Perez, Ortiz Arduan, Alberto, Pérez Gómez, María Vanessa, Martín Cleary, Catalina, Prado, Raul Fernandez, Goma, Elena, Ballarin, Jose, Encarnacion, Montserrat Diaz, Da Silva Santos, Iara, Marco Rusinol, Helena, Furlano, Monica, Arias, Carlos, Barrios, Clara, Garcia, Eva Rodriguez, Sierra Ochoa, Adriana, Vizcaino Castillo, Belen, Pantoja Perez, Jonay, Gonzalez Moya, Mercedes, Sargsyan, Mari, Calatayud Aristoy, Emma, Bernabeu, Ana Avila, Perez Lluna, Leticia, Malek Marin, Tamara, Antonia Munar Vila, Maria, Bobadilla Rico, Ivon Maritza, Allende Burgos, Natalia, Gutierrez Martinez, Eduardo, Gutierrez Solis, Elena, Sevillano, Angel, Merida Herrero, Evangelina, Miquel Blasco Pelicano, Josep, Rodas Marin, Lida Maria, Quintana, Luis F, Antonieta Azancot Rivero, Maria, Ramos Terrades, Natalia, Garcia Carro, Clara, Agraz Pamplona, Irene, Salgueira Lazo, Mercedes, de la Prada Alvarez, Francisco, Alonso Garcia, Fabiola, Adrian Aguilera Morales, Wenceslao, Virxinia Pol Heres, Salia, Forcen, Angel, Parra Moncasi, Eduardo, Medrano Villarroya, Cristina, Soria Villen, Alejandro, Gracia Garcia, Olga, Velo Plaza, Mercedes, Sánchez de la Nieta, Maria Dolores, Calvo Arevalo, Marta, Moreno, Antolina, Cigarran Guldris, Secundino, de Vicente, Manuel Pereira, Munar Vila, Maria Antonia, Hsu, Bang-Gee, Wang, Chih-Hsien, Chen, Cheng-Hsu, Yu, Tung-Min, Wu, Ming-Ju, Tsai, Shang-Feng, Hsu, Chia-Tien, Chiu, Hsien-Fu, Chou, Kang-Ju, Fang, Hua-Chang, Lee, Po-Tsang, Chen, Hsin-Yu, Chen, Chien-Liang, Huang, Chien-Wei, Ou, Shih-Hsiang, Ho, Tzung-Yo, Hsu, Chih-Yang, Chang, Ming-Shan, Chiu, Yen-Ling, Peng, Yu-Sen, Shu, Kai-Hsiang, Pan, Szu-Yu, Hsu, Shih-Ping, Yang, Ju-Yeh, Pai, Mei-Fen, Tseng, Po-Yu, Wu, Hon-Yen, Tsai, Wan-Chuan, Tung, Kuei-Ting, Chen, Hung-Yuan, Chen, Hung-Chun, Kuo, Mei-Chuan, Hwang, Daw-Yang, Chiu, Yi-Wen, Hung, Chi-Chih, Kuo, Hung-Tien, Tsai, Jer-Chia, McCafferty, Kieran, Forbes, Suzanne, Dasgupta, Indranil, Thomas, Mark, Mahdi, Amar, Ajayi, Bamidele, Chowdhury, Paramit, Kasimatis, Theodoros, Moutzouris, Dimitrios, Dudreuilh, Caroline, Pruthi, Rishi, Mansfield, Nick, Doctor, Gabriel, Shah, Sapna, Kon, Sui, Smith, Priscilla, Hamilton, Patrick, Kanigicherla, Durga, Ibrahim Ragy, Omar Sherin, Alchi, Bassam, Flossmann, Oliver, Ghalli, Farid, Lawman, Sarah, Sinha, Smeeta, Chrysochou, Constantina, Chukwu, Chukwuma, Maire De Bhailis, Aine, Al Chalabi, Saif, Hudson, Amy, Gopu, Arun, Wickens, Olivia, Storrar, Joshua, Wahba, Mona, Lorde, Nathan, Rony, Mohammad, Griffin, Sian, Latif, Farah, Ali, Mohammad, DaSilva, Louise, Ayling-Smith, Jonathan, Mahdi, Eamon, Willcocks, Lisa, Jones, Rachel, Cheung, Chee Kay, Selvaskandan, Haresh, Pugh, Dan, Sayer, Matthew, Dhaun, Neeraj, Chapman, Fiona, Mark, Patrick, Geddes, Colin, McQuarrie, Emily, Patel, Rajan, Solomon, Laurence, Ponnusamy, Arvind, Morris, Adam, Okoh, Pedro, Floyd, Lauren, Dhaygude, Ajay, Leung, Janson, Goldsmith, Christopher, Pandya, Bhavna, Tez, Didem, Mikhail, Ashraf, Brown, Karen, Bucknall, Thomas, Lambie, Mark, Comunale, Roderick, Brandon, Donald, Martinez, Stacy, Hall, Amanda, Henderson, Amy, Fearday, Aaron, Douthit, Nicole, Snow, Brian, Silva, Arnold, Sly, Cathylee, Keller, Christopher, Davidson, Robert, Meng, Jerry, Haws, Robert, Kattamanchi, Siddhartha, Mojarrab, Javad, Pillai, Unnikrishnan, Lafayette, Richard, O'Shaughnessy, Michelle, Kamal, Fahameedah, Mehta, Kshama, Baker, Bruce, Ruiz, Mario, Jyothinagaram, Praveena, Peri, Usha, Paxton, William, Tumlin, James, McGreal, Kerri, McCarthy, Ellen, Kimber, Cassandra, Gautam, Archana, Khalil, Kassem, Nguyen, Viet, Minasian, Raffi, Arfaania, Dariush, Daneshvari, Sam, Zakari, Michel, Patrikyan, Artashes, Afsari, Rouzbeh, Ayvazyan, Christine, Fakih, Faisal, Lagatta, Mark, Rodriguez, Alfred, Avella, Jorge Enrique Monroy, Patak, Ramachandra, Kadakia, Jigar, Radhakrishnan, Jai, Appel, Gerald, Ahn, Wooin, Nelson, Bradley, Medina, Allyson, Ahmad, Syeda, Peleg, Yonatan, Clement, Nisha, Chiu, Ian, Hendren, Elizabeth, Bomback, Andrew, Canetta, Pietro, Spinowitz, Bruce, Charytan, Chaim, Parikh, Nishita, Kuo, Sheng, Raichoudhury, Ritesh, Dobre, Mirela, Negrea, Lavinia, Padiyar, Aparna, Jittirat, Arksarapuk, Pradhan, Nishigandha, Dhelaria, Ranjit, Balamuthusamy, Saravanan, Madhrira, Machaiah, Powell, Thomas, Lifland, Howard, Bailey, Asha, Ford Sightler, Sarah Ashley, Suthar, Meera Patel, Green, Heather, Parikh, Samir, Ayoub, Isabelle, Almaani, Salem, Contreras, Gabriel, Fornoni, Alessia, Drexler, Yelena, Geara, Abdallah, Sheridan, Brittany, Coppock, Gaia, Hogan, Jonathan, Gonzalez, Carlos, Bhadra, Shamik, Chowdhury, Pradip, Kyaw, Kay, Tan, May, Raakesh, Lathika, Mendoza, Elder, Viramontes, Veronica, Chaudhry, Asghar, Carbonell, Juan, Gadh, Rajdeep, Fernandez, Victor, Kassem, Mohamad, Jacob, Radu, Wilder, Karen, Newsome, Britt, Klamm, Kathryn, Suyumova, Irina, Kooienga, Laura Ann, Janko, Catherine, Rizk, Dana, Julian, Bruce, Caster, Dawn, Perez, Erika, Garg, Gunjan, Gowda, Nayan, Udani, Suneel, Mandayam, Sreedhar, Workeneh, Biruh, Assefi, Ali, Greco, Barbara, Germain, Michael, Patel, Jusmin, Quinn, Sarah, Sullivan, James, Glaze, Jeffrey, Madonia, Phillip, McMahon, Kellyn, Giles, Harold, Adler, Sharon, Dai, Tiane, Heerspink, Hiddo J L, Alpers, Charles E, Bieler, Stewart, Diva, Ulysses, Inrig, Jula, Komers, Radko, Mercer, Alex, Noronha, Irene L, Rheault, Michelle N, Rote, William, Trachtman, Howard, Trimarchi, Hernán, and Perkovic, Vlado

Published
2023
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17. Effectiveness of tolvaptan on renal replacement therapy in patients with autosomal dominant polycystic kidney disease: a retrospective cohort study from the TriNetX global collaborative network.

Author

Wu, Ming-Ju, Chen, Cheng-Hsu, and Tsai, Shang-Feng

Abstract

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a major genetic contributor to end-stage kidney disease (ESKD). Current evidence on tolvaptan primarily focuses on slowing estimated glomerular filtration rate (eGFR) decline and kidney volume growth. However, direct confirmation of its effectiveness in reducing the need for hemodialysis in ESKD remains limited. We included ADPKD patients aged ≥18 years using TriNetx data from Sep 2, 2018, to Sep 3, 2023. Propensity score matching (PSM) ensured baseline comparability (standardized mean difference (SMD) <0.1). Hazard ratios (HRs) with 95% confidence intervals (CIs) evaluated outcomes, and subgroup analyses were performed. After 1:1 PSM, both groups comprised 673 patients. The average age was 45, with generally good health (3–5% diabetes, 2-3% ischemic heart disease). Baseline eGFR averaged ∼55 ml/min/1.732m2. Post-matching, all SMDs were <0.1, indicating successful matching. Tolvaptan users exhibited lower eGFR (51.45 ± 30.09 vs. 57.37 ± 33.65, p < 0.001) and higher risk of stage 4-CKD (HR: 2.436, 95% CI:1.649, 3.599) compared to non-users. However, tolvaptan users showed significantly reduced chances of initiating hemodialysis (HR:0.362, 95%CI:0.176, 0.745), experiencing urinary tract infections (HR:0.581, 95%CI:0.354, 0.956), and all-cause mortality (HR:0.355, 95% CI:0.180, 0.700). Kaplan-Meier curves for hemodialysis initiation indicated higher survival rates among tolvaptan users across age and number of medication refill subgroups. This real-world study, employing precise matching, reveals tolvaptan’s role in reducing hemodialysis initiation risk in ADPKD, despite initial hemodynamic-induced lower eGFR. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Pseudohyperkalemia in pediatric patients with newly diagnosed hematological malignancies.

Author

Li, Ting-Chu, Chan, Wei-Cheng, Tsai, Ming-Chin, Tsai, Shang-Feng, Jan, Sheng-Ling, Fu, Lin-Shien, Huang, Fang-Liang, and Huang, Yung-Chieh

Subjects
LEUKOCYTE count, CHILD patients, HEMATOLOGIC malignancies, PEDIATRIC emergency services, ERYTHROCYTES, HYPERKALEMIA
Abstract

Patients with newly diagnosed hematological malignancies often present with a considerable cellular burden, leading to complications including hyperkalemia. However, pseudohyperkalemia, arising from in vitro cell lysis, can pose challenges in clinical practice. Although pseudohyperkalemia is frequently reported in adult hematological malignancies, its occurrence in pediatric patients is underreported, and its incidence in this demographic remains unclear. We retrospectively reviewed the medical records of pediatric patients who received a new diagnosis of hematological malignancies from 2011 to 2022 at Taichung Veterans General Hospital. Hyperkalemia was defined by a serum or plasma potassium level exceeding 5.5 mEq/L. Pseudohyperkalemia was defined by 1) a potassium decrease of over 1 mEq/L in within 4 h without intervention or 2) the absence of electrocardiography changes indicative of hyperkalemia. Cases with apparent red blood cell hemolysis were excluded. A total of 157 pediatric patients with a new diagnosis of hematological malignancies were included, 14 of whom exhibited hyperkalemia. Among these 14 cases, 7 cases (4.5%) were of pseudohyperkalemia. This rate increased to 21.2% in patients with initial hyperleukocytosis. Pseudohyperkalemia was associated with a higher initial white blood cell count and lower serum sodium level. All episodes of pseudohyperkalemia occurred in the pediatric emergency department, where samples were obtained as plasma, whereas all true hyperkalemia cases were observed in the ordinary ward or intensive care unit, where samples were obtained as serum. Timely recognition of pseudohyperkalemia is crucial to avoiding unnecessary potassium-lowering interventions in pediatric patients with newly diagnosed hematological malignancies. [ABSTRACT FROM AUTHOR]

Published
2024
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27. De Novo Biopsy-Proven Glomerular Disease Following COVID-19 Vaccination.

Author

Chen, Cheng-Hsu, Chiu, Yu-Wei, Chen, Bo-Ding, Wu, Ming-Ju, and Tsai, Shang-Feng

Subjects
COVID-19, KIDNEY glomerulus diseases, IGA glomerulonephritis, ANTINEUTROPHIL cytoplasmic antibodies, RENAL biopsy, FOCAL segmental glomerulosclerosis
Abstract

Background: There is still no consensus about the coronavirus disease 2019 (COVID-19) vaccine-associated glomerular disease (CVAGD). Given the large number of vaccinations administered and the variations in glomerulopathy observed across different countries and regional environments, CVAGD remains an important area of concern. Aim of study: We aimed to elucidate the findings of CVAGD within a Taiwanese cohort using biopsy data. Additionally, we endeavored to clarify the presentation of CVAGD. Methods: We collected data from patients who underwent renal biopsy from June 2021 to October 2022 at Taichung Veterans General Hospital. Two independent nephrologists meticulously reviewed the charts to exclude cases unrelated to vaccination. Results: Initially, a total of 286 patients underwent renal biopsy at our institute. Ultimately, we identified 14 patients with highly suspected CVAGD. All 14 patients exhibited proteinuria and hematuria. The urinary protein-to-creatinine ratio was elevated (median of 2012.1 mg/g; interquartile range (IQR) 25%–IQR 75%: 941.85–3884.1 mg/g) with a median serum creatinine level of 1.71 mg/dL (0.79–5.35). The majority of CVAGD cases were diagnosed as immunoglobulin A (IgA) nephropathy (n = 5, 35.7%), followed by antineutrophil cytoplasmic antibody (ANCA)-related rapidly progressive glomerulonephritis (RPGN) (n = 4, 28.6%). There were only three cases of minimal change disease each: one case of focal segmental glomerulosclerosis, one of membranous glomerulonephritis, and one of lupus nephritis. The culprit of COVID-19 vaccinations was 35.7% (n = 5) of Oxford-AstraZeneca (ChAdOx1-S), 42.9% (n = 6) of Moderna, and 21.4% (n = 3) of BNT162b2. Most patients experienced improvements in renal function. Only two cases of P-ANCA RPGN and one case of IgA nephropathy did not recover. Eighty percent of IgA nephropathy cases had favorable outcomes, but none of the patients with P-ANCA RPGN achieved full recovery. Conclusions: IgA nephropathy and ANCA-related RPGN were the most common CVAGD, and all types of COVID-19 vaccines posed a risk for CVAGD. However, further studies are required to confirm causality. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Reducing Waiting Times and Admission Periods through Pre-Admission Testing: A Quality Improvement Study on In-Hospital Renal Biopsy.

Author

Tsai, Shang-Feng, Hsu, Chia-Tien, Chung, Mu-Chi, Wu, Ming-Ju, Huang, Ya-Chin, and Chen, Cheng-Hsu

Subjects
*RENAL biopsy, *DELAYED diagnosis, *BLOOD transfusion, *STATISTICAL significance, *PATIENT care
Abstract

Background: Admission for renal biopsy is considered the gold standard for diagnosing kidney disease. However, prolonged waiting times for admission can lead to delayed diagnosis. Despite this issue, there are currently no studies demonstrating how to improve the efficiency of renal biopsy procedures. Methods: We initiated a quality improvement project to implement pre-admission testing (PAT) for renal biopsy from 2016 to 2024 (until 15 April). Our evaluation focused on waiting times for admission, length of admission periods, hospitalization expenses, percentage of cases with no renal biopsy performed, incidence of severe bleeding due to renal biopsy, and percentage of cases with adequate tissue samples obtained. Additionally, we highlighted the time periods during the outbreak of SARS-CoV-2. Results: The highest annual case number was observed in time period 1 (168.3/year). Following the outbreak of SARS-CoV-2, there was a notable decrease in case numbers during time period 2 (119.8), which then increased to 143.0 in time period 3 (post-SARS-CoV-2 era). The mean waiting time was 13.72 ± 40.30 days for time period 1 and 10.00 ± 47.80 days for time period 2, without statistical significance. Following the implementation of PAT, patients now only need to wait approximately 0.76 days for admission, representing a significant reduction in waiting time. Subsequently, following the implementation of PAT, the waiting time decreased significantly to 2.09 ± 2.65 days. Additionally, hospitalization expenses per patient significantly decreased from approximately USD 69.62 ± 97.09 to USD 41.66 ± 52.82. The percentage of missed biopsy is significantly low (p < 0.001). Severe bleeding events (indicated as embolization and blood transfusion) were consistent across the three time periods (p = 0.617). Conclusions: The implementation of PAT can improve the pre-admission process for renal biopsy, resulting in decreased waiting times, fewer missed appointments, shorter admission durations, and reduced hospitalization expenses. We propose implementing PAT for outpatient individuals awaiting in-hospital renal biopsy procedures to mitigate delayed diagnosis, reduce pre-admission waiting periods, and streamline admission processes, thereby enhancing overall patient care efficiency. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

Author

Rovin, Brad H, primary, Barratt, Jonathan, additional, Heerspink, Hiddo J L, additional, Alpers, Charles E, additional, Bieler, Stewart, additional, Chae, Dong-Wan, additional, Diva, Ulysses A, additional, Floege, Jürgen, additional, Gesualdo, Loreto, additional, Inrig, Jula K, additional, Kohan, Donald E, additional, Komers, Radko, additional, Kooienga, Laura Ann, additional, Lafayette, Richard, additional, Maes, Bart, additional, Małecki, Robert, additional, Mercer, Alex, additional, Noronha, Irene L, additional, Oh, Se Won, additional, Peh, Chen Au, additional, Praga, Manuel, additional, Preciado, Priscila, additional, Radhakrishnan, Jai, additional, Rheault, Michelle N, additional, Rote, William E, additional, Tang, Sydney C W, additional, Tesar, Vladimir, additional, Trachtman, Howard, additional, Trimarchi, Hernán, additional, Tumlin, James A, additional, Wong, Muh Geot, additional, Perkovic, Vlado, additional, Abbasciano, Isabella, additional, Abrantes, Catarina, additional, Accarino, Simone, additional, Adler, Sharon, additional, Adoberg, Annika, additional, Afsari, Rouzbeh, additional, Ahmad, Syeda, additional, Ahmed, Jafar, additional, Ahn, Wooin, additional, Ajayi, Bamidele, additional, Aksamit, Dariusz, additional, Al Chalabi, Saif, additional, Alamartine, Eric, additional, Alchi, Bassam, additional, Ali, Mohammad, additional, Aliotta, Roberta, additional, Almaani, Salem, additional, Almeida, Catarina, additional, Almeida, Edgar, additional, Alvarez, Francisco de la Prada, additional, Alves, Patricia, additional, Annese, Francesca, additional, Appel, Gerald, additional, Arduan, Alberto Ortiz, additional, Arena, Maria, additional, Arevalo, Marta Calvo, additional, Arfaania, Dariush, additional, Arias, Carlos, additional, Aristoy, Emma Calatayud, additional, Asakiene, Egle, additional, Ashley, Sarah, additional, Assefi, Ali, additional, Atenza, Alba, additional, Auerbach, Asta, additional, Augustyniak-Bartosik, Hanna, additional, Avella, Monroy, additional, Ayling-Smith, Jonathan, additional, Ayoub, Isabelle, additional, Ayvazyan, Christine, additional, Baccaro, Rocco, additional, Bailey, Asha, additional, Baker, Bruce, additional, Balamuthusamy, Saravanan, additional, Ballarin, Jose, additional, Barata, Rui, additional, Barbic, Jerko, additional, Barisic, Dunja, additional, Barreto, Jose Carlos de Jesus, additional, Barrios, Clara, additional, Belingheri, Mirco, additional, Benesova, Anna, additional, Bernabeu, Ana Avila, additional, Bernhardt, Wanja, additional, Bhadra, Shamik, additional, Biancone, Luigi, additional, Blanchard, Anne, additional, Boaglio, Elena, additional, Bolignano, Davide, additional, Bomback, Andrew, additional, Bonilla, Gustavo Andres Useche, additional, Bordoli, Monica, additional, Bose, Bhadran, additional, Boudville, Neil, additional, Brandon, Donald, additional, Brown, Karen, additional, Broyet, Christian, additional, Bucknall, Thomas, additional, Buffet, Alexandre, additional, Bumblyte', Inga Arune, additional, Burdese, Manuel, additional, Burgos, Natalia Allende, additional, Burguet, Laure, additional, Burtey, Stephane, additional, Busch, Martin, additional, Cakiroglu, Figen, additional, Campbell, Victoria, additional, Canetta, Pietro, additional, Capaccio, Flavia, additional, Carbonell, Juan, additional, Cardoso, Filipa, additional, Carro, Clara Garcia, additional, Carroll, Robert, additional, Carron, Pierre-Louis, additional, Carullo, Nazareno, additional, Cassia, Matthias, additional, Caster, Dawn, additional, Castillo, Belen Vizcaino, additional, Catucci, Davide, additional, Cavalli, Andrea, additional, Chakera, Aron, additional, Chan, Doris, additional, Chan, Gary Chi Wang, additional, Chan, Anthony Ting Pong, additional, Chan, Lai Wan, additional, Chang, Jae Hyun, additional, Chang, Ming-Shan, additional, Chapman, Fiona, additional, Charytan, Chaim, additional, Chaudhry, Asghar, additional, Cheetham, Melissa, additional, Chen, Cheng-Hsu, additional, Chen, Hsin-Yu, additional, Chen, Chien-Liang, additional, Chen, Hung-Yuan, additional, Chen, Hung-Chun, additional, Chenine, Leila, additional, Cheung, Siu Fai, additional, Cheung, Chee Kay, additional, Chiche-Jourde, Noemie, additional, Chiu, Hsien-Fu, additional, Chiu, Yen-Ling, additional, Chiu, Yi-Wen, additional, Chiu, Ian, additional, Choi, Hoon Young, additional, Chou, Kang-Ju, additional, Chowdhury, Paramit, additional, Chowdhury, Pradip, additional, Chrysochou, Constantina, additional, Chukwu, Chukwuma, additional, Chun, Ka Yeong, additional, Chung, Wookyung, additional, Cieniawski, Dominik, additional, Claisse, Guillaume, additional, Clayton, Philip, additional, Cleary, Catalina Martín, additional, Clement, Nisha, additional, Coates, Toby, additional, Cogno, Chiara, additional, Colla, Loredana, additional, Collins, Michael, additional, Colucci, Marco, additional, Combe, Christian, additional, Comi, Nicolino, additional, Comunale, Roderick, additional, Contreras, Gabriel, additional, Cooper, Bruce, additional, Coppock, Gaia, additional, Costa, Ana Cortesão, additional, Costanzi, Stefano, additional, Cozzolino, Mario, additional, Crail, Susan, additional, Cunha, Liliana, additional, Curry, Elizabeth, additional, Dai, Tiane, additional, Daina, Erica, additional, Daneshvari, Sam, additional, Dasgupta, Indranil, additional, DaSilva, Louise, additional, Davidson, Robert, additional, De Bhailis, Aine Maire, additional, de Précigout, Valérie, additional, Decupere, Marc, additional, Delmas, Yahsou, additional, Deodato, Francesca, additional, Dhaun, Neeraj, additional, Dhaygude, Ajay, additional, Dhelaria, Ranjit, additional, Di Maio, Federica, additional, Diezhandino, Maria Angeles Goicoechea, additional, Dika, Zivka, additional, Dinic, Miriana, additional, Dittmer, Ian, additional, Dobre, Mirela, additional, Doctor, Gabriel, additional, Donati, Gabriele, additional, Doubel, Peter, additional, Douthit, Nicole, additional, Draganova, Diliana, additional, Drexler, Yelena, additional, Drinkovic, Martin, additional, Drinovska, Klara, additional, Dudreuilh, Caroline, additional, Dumond, Clement, additional, Durlen, Ivan, additional, Dussol, Bertrand, additional, Encarnacion, Montserrat Diaz, additional, Endre, Zoltan, additional, Enrique, Jorge, additional, Eqbal, Yusuf, additional, Erlich, Jonathan, additional, Esposito, Vittoria, additional, Esposito, Ciro, additional, Fakih, Faisal, additional, Fang, Hua-Chang, additional, Farinha, Ana, additional, Fearday, Aaron, additional, Felgueiras, Joana de Sousa Soares, additional, Felicjanczuk, Elzbieta, additional, Fernandes, João Carlos, additional, Fernandes, Sara, additional, Fernandes, Adriana, additional, Fernandez, Jose Luño, additional, Fernandez, Victor, additional, Fernando, Mangalee, additional, Figueiredo, Ana Carolina, additional, Firre, Eric, additional, Flossmann, Oliver, additional, Floyd, Lauren, additional, Fonseca, Nuno, additional, Fonseca, Jose Nuno de Almeida Agapito, additional, Foote, Celine, additional, Forbes, Suzanne, additional, Forcen, Angel, additional, Fornoni, Alessia, additional, Fouassier, David, additional, Fraser, Ian, additional, Fung, Ka Shun Samuel, additional, Furlano, Monica, additional, Furtado, Teresa, additional, Gadh, Rajdeep, additional, Gaisset, Roxane, additional, Gallagher, Martin, additional, Gameiro, Joana, additional, Gangadharan, Muralikrishna, additional, Garcia, Fabiola Alonso, additional, Garcia, Olga Gracia, additional, Garg, Gunjan, additional, Garrouste, Cyril, additional, Gautam, Archana, additional, Geara, Abdallah, additional, Geddes, Colin, additional, Gellineo, Lana, additional, Germain, Michael, additional, Ghalli, Farid, additional, Giaroni, Francesco, additional, Giles, Harold, additional, Gillies, Alastair, additional, Gimeno, Ana Vilar, additional, Girardet, Annette, additional, Glaze, Jeffrey, additional, Goh, Tze, additional, Gois, Mario, additional, Goldsmith, Christopher, additional, Goma, Elena, additional, Gomes, Ana Marta, additional, Goncalves, Luis Pedro Falcao, additional, Goncalves, Sara, additional, Gontarek-Kacprzak, Julita, additional, Gonzalez, Carlos, additional, Gopu, Arun, additional, Gowda, Nayan, additional, Gray, Nicholas, additional, Greco, Barbara, additional, Green, Heather, additional, Greze, Clarisse, additional, Griffin, Sian, additional, Guldris, Secundino Cigarran, additional, Guzman, Ursula Verdalles, additional, Ha, Jeffrey Tsun Kit, additional, Hall, Amanda, additional, Hamilton, Patrick, additional, Han, Seung Hyeok, additional, Haws, Robert, additional, Hayat, Ashik, additional, Heath, Lauren, additional, Heinrichs, Sven, additional, Henderson, Andrew, additional, Henderson, Amy, additional, Hendren, Elizabeth, additional, Heng, Anne-Elisabeth, additional, Heres, Salia Virxinia Pol, additional, Herfurth, Johann Konstantin, additional, Herrero, Evangelina Merida, additional, Ho, Tzung-Yo, additional, Hogan, Jonathan, additional, Hohenstein, Bernd, additional, Hollett, Peter, additional, Horvatic, Ivica, additional, Hsu, Bang-Gee, additional, Hsu, Chia-Tien, additional, Hsu, Chih-Yang, additional, Hsu, Shih-Ping, additional, Huang, Chien-Wei, additional, Hudson, Amy, additional, Hung, Chi-Chih, additional, Hwang, Shang-Jyh, additional, Hwang, Daw-Yang, additional, Hyun, Young Youl, additional, Ilmoja, Madis, additional, Irish, Georgina, additional, Jacob, Radu, additional, Jahan, Sadia, additional, Jain, Arunima, additional, Jamar, Sofie, additional, Jander, Anna, additional, Jang, Hye Ryoun, additional, Janko, Catherine, additional, Jardine, Meg, additional, Jaskowski, Piotr, additional, Jeantet, Guillaume, additional, Jelakovic, Bojan, additional, Jeon, Junseok, additional, Jeong, Jong Cheol, additional, Jesudason, Shilpanjali, additional, Jittirat, Arksarapuk, additional, Jo, Sang-Kyung, additional, Jones, Rachel, additional, Joo, Narae, additional, Jorge, Sofia, additional, Julian, Bruce, additional, Jung, JiYong, additional, Jyothinagaram, Praveena, additional, Kadakia, Jigar, additional, Kamal, Fahameedah, additional, Kanigicherla, Durga, additional, Karanovic, Sandra, additional, Karras, Alexandre, additional, Kasimatis, Theodoros, additional, Kassem, Mohamad, additional, Kattamanchi, Siddhartha, additional, Keller, Christopher, additional, Kentric, Dubravka Trajbar, additional, Kettner, Christiane, additional, Khalil, Kassem, additional, Kim, Dana, additional, Kim, Se Joong, additional, Kim, Yeong Hoon, additional, Kim, Yunmi, additional, Kim, Hyung Wook, additional, Kim, Sunggyun, additional, Kim, Jwa-Kyung, additional, Kim, Aejin, additional, Kim, Myung-Gyu, additional, Kimber, Cassandra, additional, Klamm, Kathryn, additional, Koch, Annegret, additional, Koester, Eric, additional, Kolvald, Kulli, additional, Kon, Sui, additional, Kotwal, Sradha, additional, Krajewska, Magdalena, additional, Kratka, Karolina, additional, Krishnan, Anoushka, additional, Krishnasamy, Rathika, additional, Krueger, Thilo, additional, Kruljac, Ivan, additional, Kulka, Simone, additional, Kunzendorf, Ulrich, additional, Kuo, Mei-Chuan, additional, Kuo, Hung-Tien, additional, Kuo, Sheng, additional, Kwan, Lorraine Pui Yuen, additional, Kwella, Norbert, additional, Kwella, Bogna, additional, Kyaw, Kay, additional, Labat, Aurore, additional, Lagatta, Mark, additional, Lam, Chi Kwan Darwin, additional, Lambie, Mark, additional, Lanaret, Camille, additional, Latif, Farah, additional, Laute, Margo, additional, Law, Wai Ping, additional, Lawman, Sarah, additional, Lazo, Mercedes Salgueira, additional, Lee, Hajeong, additional, Lee, Moon Hyoung, additional, Lee, Kyu-Beck, additional, Lee, Hyung-seok, additional, Lee, JungEun, additional, Lee, Hyun Hee, additional, Lee, Po-Tsang, additional, Leis, Liisi, additional, Lemahieu, Wim, additional, Leung, Janson, additional, Li, Yan, additional, Lie, Davina Ngoi Wah, additional, Lifland, Howard, additional, Lilienthal, Kadri, additional, Lim, Wai, additional, Limardo, Monica, additional, Livrozet, Marine, additional, Longhi, Selena, additional, Lopes, Daniela, additional, Lopes, Jose Antonio, additional, Lorde, Nathan, additional, Luxton, Grant, additional, Ma, Mingyao, additional, Madhrira, Machaiah, additional, Madonia, Phillip, additional, Mahadevan, Kumaradevan, additional, Mahdi, Amar, additional, Mahdi, Eamon, additional, Maillard, Nicolas, additional, Maixnerova, Dita, additional, Majstorovic Barac, Karolina, additional, Malecki, Robert, additional, Malfait, Thomas, additional, Malvica, Silvia, additional, Mandayam, Sreedhar, additional, Manley, Paul, additional, Mansfield, Nick, additional, Marcantoni, Carmelita, additional, Mariat, Christophe, additional, Marin, Tamara Malek, additional, Marin, Lida Maria Rodas, additional, Mark, Patrick, additional, Marques, Joana, additional, Martinez, Eduardo Gutierrez, additional, Martinez, Stacy, additional, Masset, Catherine, additional, Masson, Ingrid, additional, Mather, Amanda, additional, Maung Myint, Thida Maung, additional, Mayet, Valentin, additional, McCafferty, Kieran, additional, McCarthy, Ellen, additional, McDonald, Stephen, additional, McGreal, Kerri, additional, McMahon, Kellyn, additional, McNally, Andrew, additional, McQuarrie, Emily, additional, Medina, Allyson, additional, Meeus, Gert, additional, Mehta, Kshama, additional, Mendoza, Elder, additional, Menezes, Maria, additional, Meng, Jerry, additional, Messa, Piergiorgio, additional, Messias, Ana, additional, Miarka, Przemyslaw, additional, Miglinas, Marius, additional, Mikacic, Ivana, additional, Mikhail, Ashraf, additional, Milicevic, Martina, additional, Minasian, Raffi, additional, Moeller, Marcus, additional, Mohey, Hesham, additional, Mojarrab, Javad, additional, Mok, Maggie Ming Yee, additional, Moncasi, Eduardo Parra, additional, Moonen, Martial, additional, Morales, Wenceslao Adrian Aguilera, additional, Moreno, Eduardo Verde, additional, Moreno, Antolina, additional, Morris, Adam, additional, Moutzouris, Dimitrios, additional, Moya, Mercedes Gonzalez, additional, Mucha, Simon, additional, Musolino, Michela, additional, Napodano, Pietro, additional, Natario, Ana, additional, Negrea, Lavinia, additional, Nelson, Bradley, additional, Neuen, Brendon, additional, Newsome, Britt, additional, Ng, Kit Chung Jack, additional, Nguyen, Thu, additional, Nguyen, Viet, additional, Nicolo, Clementine, additional, Nitschke, Martin, additional, Noble, Euan, additional, Nolasco, Fernando, additional, O'Lone, Emma, additional, Ochoa, Adriana Sierra, additional, Oh, Kook-Hwan, additional, Oh, SeWon, additional, Okoh, Pedro, additional, Ombelet, Sara, additional, O'Shaughnessy, Michelle, additional, Ou, Shih-Hsiang, additional, Packham, David, additional, Padiyar, Aparna, additional, Pai, Mei-Fen, additional, Pamplona, Irene Agraz, additional, Pan, Szu-Yu, additional, Pandya, Bhavna, additional, Papadia, Federica, additional, Pardinhas, Clara, additional, Parikh, Nishita, additional, Parikh, Samir, additional, Park, Hyeong Cheon, additional, Park, Jung Tak, additional, Parreira, Lucia, additional, Passerini, Patrizia, additional, Patak, Ramachandra, additional, Patecki, Margret, additional, Patel, Rajan, additional, Patel, Jusmin, additional, Patel Suthar, Meera, additional, Patella, Gemma, additional, Patrikyan, Artashes, additional, Pavlovic, Drasko, additional, Paxton, William, additional, Peh, Chen, additional, Peleg, Yonatan, additional, Pelicano, Josep Miquel Blasco, additional, Peng, Yu-Sen, additional, Pereira de Vicente, Manuel, additional, Perez, Jonay Pantoja, additional, Perez, Erika, additional, Perez de Jose, Ana, additional, Pérez Gómez, María Vanessa, additional, Perez Lluna, Leticia, additional, Peri, Usha, additional, Perico, Norberto, additional, Philipponnet, Carole, additional, Phua, Elaine, additional, Piel, Julia, additional, Pillai, Unnikrishnan, additional, Pilmore, Helen, additional, Plavljanic, Djuro, additional, Plaza, Mercedes Velo, additional, Pollock, Carol, additional, Ponnusamy, Arvind, additional, Ponti, Serena, additional, Powell, Thomas, additional, Pradhan, Nishigandha, additional, Prado, Raul Fernandez, additional, Prkacin, Ingrid, additional, Pruthi, Rishi, additional, Pugh, Dan, additional, Quinn, Sarah, additional, Quintana, Luis F, additional, Raakesh, Lathika, additional, Rabindranath, Kannaiyan, additional, Radermacher, Luc, additional, Ragy, Omar Sherin Ibrahim, additional, Raichoudhury, Ritesh, additional, Raimundo, Mario, additional, Randone, Paolo, additional, Razavian, Mona, additional, Reichel, Helmut, additional, Reis, Marina, additional, Remuzzi, Giuseppe, additional, Reynolds, Annie, additional, Ricchiuto, Anna, additional, Rico, Ivon Maritza Bobadilla, additional, Rigothier, Claire, additional, Ritchie, Angus, additional, Rivero, Maria Antonieta Azancot, additional, Rizk, Dana, additional, Ro, Han, additional, Rodriguez, Alfred, additional, Rodriguez Garcia, Eva, additional, Roger, Simon, additional, Rony, Mohammad, additional, Rosenberg, Mai, additional, Roueff, Stephane, additional, Rovin, Brad, additional, Roxburgh, Sarah, additional, Ruiz, Mario, additional, Rusinol, Helena Marco, additional, Rychlik, Ivan, additional, Sá, Helena, additional, Salehi, Tania, additional, Sánchez de la Nieta, Maria Dolores, additional, Sanden, Silja, additional, Santockiene, Lina, additional, Santos, Patricia Valerio, additional, Santos, Iara Da Silva, additional, Sargsyan, Mari, additional, Sarnow, Franziska, additional, Sat, Sebahat, additional, Satora, Ewa, additional, Savuk, Ana, additional, Sayer, Matthew, additional, Schlieper, Georg, additional, Schlosser, Mandy, additional, Schmidt-Guertler, Hans, additional, Schockaert, Olivier, additional, Schulte, Kevin, additional, Schulz, Lisa, additional, Selvaskandan, Haresh, additional, Semple, David, additional, Sen, Shaundeep, additional, Seppet, Elviira, additional, Serrano, Antonio Galan, additional, Serre, Jean-Emmanuel, additional, Sevillano, Angel, additional, Shah, Sapna, additional, Shen, Yvonne, additional, Sheridan, Brittany, additional, Shu, Kai-Hsiang, additional, Sightler, Ford, additional, Silva, Sónia, additional, Silva, Arnold, additional, Sinha, Smeeta, additional, Siriwardana, Amanda, additional, Sitas, Zvonimir, additional, Sivo, Carmen, additional, Sizeland, Peter, additional, Sly, Cathylee, additional, Smith, Priscilla, additional, Snow, Brian, additional, Soares, Elsa Sofia Quadrado, additional, Solazzo, Andrea, additional, Solis, Elena Gutierrez, additional, Solomon, Laurence, additional, Song, Young Rim, additional, Sousa, Helena, additional, Spinowitz, Bruce, additional, Stallworthy, Elizabeth, additional, Stamellou, Eleni, additional, Stanczyk, Malgorzata, additional, Stangenberg, Stefanie, additional, Stankovic, Marija, additional, Stankuviene, Asta, additional, Stea, Emma Diletta, additional, Stompor, Tomasz, additional, Storrar, Joshua, additional, Sullivan, James, additional, Sulowicz, Wladyslaw, additional, Suyumova, Irina, additional, Szeto, Cheuk Chun, additional, Tamarit, Esther, additional, Tan, Eddie, additional, Tan, May, additional, Tang, Sydney Chi Wai, additional, Tang, Hon, additional, Teixeira, Catarina, additional, Telling, Kadri, additional, Terrades, Natalia Ramos, additional, Tez, Didem, additional, Thervet, Eric, additional, Thibaudin, Damien, additional, Thomas, Mark, additional, Thyagarajan, Nikhil, additional, Tkaczyk, Marcin, additional, Torreggiani, Massimo, additional, Trillini, Matias, additional, Tsai, Shang-Feng, additional, Tsai, Wan-Chuan, additional, Tsai, Jer-Chia, additional, Tseng, Po-Yu, additional, Tumlin, James, additional, Tung, Kuei-Ting, additional, Turnbull, Angus, additional, Udani, Suneel, additional, Uhlinova, Jana, additional, Unt, Kristin, additional, Urciuolo, Federica, additional, Vanacker, An, additional, Vandewiele, Bert, additional, Vaz, Alvaro, additional, Veermae, Kristi, additional, Viaene, Liesbeth, additional, Vickiene, Alvita, additional, Vigano, Sara, additional, Vila, Maria Antonia Munar, additional, Vilayur, Eswari, additional, Villanueva, Caridad Martinez, additional, Villarroya, Cristina Medrano, additional, Villen, Alejandro Soria, additional, Viramontes, Veronica, additional, Vita, Caterina, additional, Vujcic, Dunja, additional, Wahba, Mona, additional, Wan, Susan, additional, Wang, Chih-Hsien, additional, Warling, Xavier, additional, Waters, Gerald, additional, Waugh, Jane, additional, Weiland, Lea, additional, Weiner, Stefan, additional, Weinreich, Thomas, additional, Werth, Stephan Christian, additional, Wickens, Olivia, additional, Wijeratne, Vidu, additional, Wilder, Karen, additional, Willcocks, Lisa, additional, Williams, Allister, additional, Winiarska, Agata, additional, Wirtz, Nikolaus, additional, Wolf, Lothar, additional, Wolf, Gunter, additional, Wong, Yick Hei, additional, Wong, Sze Ho Sunny, additional, Workeneh, Biruh, additional, Wu, Ming-Ju, additional, Wu, Hon-Yen, additional, Wyndham, Roger, additional, Yang, Jihyun, additional, Yang, Ju-Yeh, additional, Yeap, Chii, additional, Yim, Ka Fai, additional, Yong, Kenneth, additional, Yoo, Tae-Hyun, additional, Yoon, Songuk, additional, Yu, Tung-Min, additional, Yue, Tak Tai Andrew, additional, Zakari, Michel, additional, Zakauskiene, Urte, additional, Zaoui, Philippe, additional, Zbrzezniak, Justyna, additional, Zielinska, Dorota, additional, and Zizzi, Carlotta Federica, additional

Published
2023
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38. Effects of down‐regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines.

Author

Wu, Cheng‐Yen, Yu, Jia‐Yo, Chen, Yi‐Shan, Chang, Hui‐Ping, Hsieh, Benjamin Y., Lin, Yu‐Hsin, Ma, Chung‐Yung, Tsai, Shang‐Feng, and Hsieh, Mingli

Subjects
CARBONIC anhydrase, GLUCOSE transporters, BENZENESULFONAMIDES, COLORECTAL cancer, CANCER cells, GLUCOSE metabolism, CELL survival
Abstract

Carbonic anhydrase 8 (CA8) is a member of the α‐carbonic anhydrase family but does not catalyze the reversible hydration of carbon dioxide. In the present study, we examined the effects of CA8 on two human colon cancer cell lines, SW480 and SW620, by suppressing CA8 expression through shRNA knockdown. Our results showed that knockdown of CA8 decreased cell growth and cell mobility in SW620 cells, but not in SW480 cells. In addition, downregulated CA8 resulted in a significant decrease of glucose uptake in both SW480 and SW620 cells. Interestingly, stable downregulation of CA8 decreased phosphofructokinase‐1 expression but increased glucose transporter 3 (GLUT3) levels in SW620 cells. However, transient downregulation of CA8 fails to up‐regulate GLUT3 expression, indicating that the increased GLUT3 observed in SW620‐shCA8 cells is a compensatory effect. In addition, the interaction between CA8 and GLUT3 was evidenced by pull‐down and IP assays. On the other hand, we showed that metformin, a first‐line drug for type II diabetes patients, significantly inhibited cell migration of SW620 cells, depending on the expressions of CA8 and focal adhesion kinase. Taken together, our data demonstrate that when compared to primary colon cancer SW480 cells, metastatic colon cancer SW620 cells respond differently to downregulated CA8, indicating that CA8 in more aggressive cancer cells may play a more important role in controlling cell survival and metformin response. CA8 may affect glucose metabolism‐ and cell invasion‐related molecules in colon cancer, suggesting that CA8 may be a potential target in future cancer therapy. Significance statement: This study demonstrates that when compared to primary colon cancer SW480 cells, metastatic colon cancer SW620 cells respond differently to downregulated CA8, indicating that CA8 in more aggressive cancer cells may play a more important role in controlling cell survival and metformin response. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Author

Heerspink, Hiddo J L, primary, Radhakrishnan, Jai, additional, Alpers, Charles E, additional, Barratt, Jonathan, additional, Bieler, Stewart, additional, Diva, Ulysses, additional, Inrig, Jula, additional, Komers, Radko, additional, Mercer, Alex, additional, Noronha, Irene L, additional, Rheault, Michelle N, additional, Rote, William, additional, Rovin, Brad, additional, Trachtman, Howard, additional, Trimarchi, Hernán, additional, Wong, Muh Geot, additional, Perkovic, Vlado, additional, Alarmartine, Eric, additional, Chae, Dong Wan, additional, Del Vecchio, Lucia, additional, Floege, Jurgen, additional, Hwang, Shang-Jyh, additional, Jelakovic, Bojan, additional, Maes, Bart, additional, Malecki, Robert, additional, Miglinas, Marius, additional, Nolasco, Fernando Eduardo Barbosa, additional, Praga, Manual, additional, Rabindranath, Kannaiyan, additional, Rosenberg, Mai, additional, Tang, Sydney Chi Wai, additional, Tesar, Vladmir, additional, Bose, Bhadran, additional, Gangadharan, Muralikrishna, additional, McDonald, Stephen, additional, Peh, Chen, additional, Jahan, Sadia, additional, Yeap, Chii, additional, Clayton, Philip, additional, Irish, Georgina, additional, Thyagarajan, Nikhil, additional, Hollett, Peter, additional, Krishnasamy, Rathika, additional, Carroll, Robert, additional, Jesudason, Shilpanjali, additional, Crail, Susan, additional, Coates, Toby, additional, Waugh, Jane, additional, Noble, Euan, additional, Mahadevan, Kumaradevan, additional, Campbell, Victoria, additional, Salehi, Tania, additional, Lim, Wai, additional, Boudville, Neil, additional, Chakera, Aron, additional, Chan, Doris, additional, Krishnan, Anoushka, additional, Eqbal, Yusuf, additional, Gillies, Alastair, additional, Vilayur, Eswari, additional, Maung Myint, Thida Maung, additional, Gray, Nicholas, additional, Cheetham, Melissa, additional, Pollock, Carol, additional, Cooper, Bruce, additional, Mather, Amanda, additional, Roxburgh, Sarah, additional, Shen, Yvonne, additional, Stangenberg, Stefanie, additional, Siriwardana, Amanda, additional, O'Lone, Emma, additional, Wan, Susan, additional, Neuen, Brendon, additional, Tsun Kit Ha, Jeffrey, additional, Kim, Dana, additional, Heath, Lauren, additional, Jain, Arunima, additional, Phua, Elaine, additional, Li, Yan, additional, Gallagher, Martin, additional, Jardine, Meg, additional, Ritchie, Angus, additional, Razavian, Mona, additional, Foote, Celine, additional, Wyndham, Roger, additional, Sen, Shaundeep, additional, Endre, Zoltan, additional, Erlich, Jonathan, additional, Fernando, Mangalee, additional, Yong, Kenneth, additional, Luxton, Grant, additional, Kotwal, Sradha, additional, Roger, Simon, additional, Wijeratne, Vidu, additional, Packham, David, additional, Fraser, Ian, additional, Vandewiele, Bert, additional, Laute, Margo, additional, Lemahieu, Wim, additional, Jamar, Sofie, additional, Ombelet, Sara, additional, Meeus, Gert, additional, Decupere, Marc, additional, Schockaert, Olivier, additional, Doubel, Peter, additional, Viaene, Liesbeth, additional, Radermacher, Luc, additional, Masset, Catherine, additional, Moonen, Martial, additional, Firre, Eric, additional, Milicevic, Martina, additional, Warling, Xavier, additional, Vanacker, An, additional, Malfait, Thomas, additional, Durlen, Ivan, additional, Horvatic, Ivica, additional, Savuk, Ana, additional, Gellineo, Lana, additional, Karanovic, Sandra, additional, Dika, Zivka, additional, Plavljanic, Djuro, additional, Mikacic, Ivana, additional, Trajbar Kentric, Dubravka, additional, Barisic, Dunja, additional, Stankovic, Marija, additional, Majstorovic Barac, Karolina, additional, Kruljac, Ivan, additional, Pavlovic, Drasko, additional, Drinkovic, Martin, additional, Prkacin, Ingrid, additional, Barbic, Jerko, additional, Sitas, Zvonimir, additional, Vujcic, Dunja, additional, Rychlik, Ivan, additional, Benesova, Anna, additional, Drinovska, Klara, additional, Kratka, Karolina, additional, Maixnerova, Dita, additional, Ilmoja, Madis, additional, Unt, Kristin, additional, Lilienthal, Kadri, additional, Auerbach, Asta, additional, Leis, Liisi, additional, Piel, Julia, additional, Adoberg, Annika, additional, Kolvald, Kulli, additional, Veermae, Kristi, additional, Telling, Kadri, additional, Seppet, Elviira, additional, Uhlinova, Jana, additional, Zaoui, Philippe, additional, Carron, Pierre-Louis, additional, Masson, Ingrid, additional, Dinic, Miriana, additional, Thibaudin, Damien, additional, Broyet, Christian, additional, Maillard, Nicolas, additional, Mohey, Hesham, additional, Mariat, Christophe, additional, Claisse, Guillaume, additional, Alamartine, Eric, additional, Dussol, Bertrand, additional, Burtey, Stephane, additional, Chiche-Jourde, Noemie, additional, Serre, Jean-Emmanuel, additional, Jeantet, Guillaume, additional, Chenine, Leila, additional, Blanchard, Anne, additional, Roueff, Stephane, additional, Thervet, Eric, additional, Fouassier, David, additional, Buffet, 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Almeida Agapito Fonseca, Jose Nuno, additional, Goncalves, Sara, additional, Farinha, Ana, additional, Valerio Santos, Patricia, additional, Natario, Ana, additional, de Jesus Barreto, Jose Carlos, additional, Abrantes, Catarina, additional, Quadrado Soares, Elsa Sofia, additional, Soares Felgueiras, Joana de Sousa, additional, Cunha, Liliana, additional, Parreira, Lucia, additional, Furtado, Teresa, additional, Vaz, Alvaro, additional, Oh, Kook-Hwan, additional, Lee, Hajeong, additional, Joong Kim, Se, additional, Jeong, Jong Cheol, additional, Hoon Kim, Yeong, additional, Kim, Yunmi, additional, Park, Hyeong Cheon, additional, Choi, Hoon Young, additional, Wook Kim, Hyung, additional, Lee, Moon Hyoung, additional, Yoon, Songuk, additional, Lee, Kyu-Beck, additional, Hyun, YoungYoul, additional, Yoo, Tae-Hyun, additional, Han, Seung Hyeok, additional, Park, Jung Tak, additional, Kim, Sunggyun, additional, Song, Young Rim, additional, Kim, Jwa-Kyung, additional, Lee, Hyung-seok, 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additional, Chen, Hsin-Yu, additional, Chen, Chien-Liang, additional, Huang, Chien-Wei, additional, Ou, Shih-Hsiang, additional, Ho, Tzung-Yo, additional, Hsu, Chih-Yang, additional, Chang, Ming-Shan, additional, Chiu, Yen-Ling, additional, Peng, Yu-Sen, additional, Shu, Kai-Hsiang, additional, Pan, Szu-Yu, additional, Hsu, Shih-Ping, additional, Yang, Ju-Yeh, additional, Pai, Mei-Fen, additional, Tseng, Po-Yu, additional, Wu, Hon-Yen, additional, Tsai, Wan-Chuan, additional, Tung, Kuei-Ting, additional, Chen, Hung-Yuan, additional, Chen, Hung-Chun, additional, Kuo, Mei-Chuan, additional, Hwang, Daw-Yang, additional, Chiu, Yi-Wen, additional, Hung, Chi-Chih, additional, Kuo, Hung-Tien, additional, Tsai, Jer-Chia, additional, McCafferty, Kieran, additional, Forbes, Suzanne, additional, Dasgupta, Indranil, additional, Thomas, Mark, additional, Mahdi, Amar, additional, Ajayi, Bamidele, additional, Chowdhury, Paramit, additional, Kasimatis, Theodoros, additional, Moutzouris, Dimitrios, additional, Dudreuilh, Caroline, additional, Pruthi, Rishi, additional, Mansfield, Nick, additional, Doctor, Gabriel, additional, Shah, Sapna, additional, Kon, Sui, additional, Smith, Priscilla, additional, Hamilton, Patrick, additional, Kanigicherla, Durga, additional, Ibrahim Ragy, Omar Sherin, additional, Alchi, Bassam, additional, Flossmann, Oliver, additional, Ghalli, Farid, additional, Lawman, Sarah, additional, Sinha, Smeeta, additional, Chrysochou, Constantina, additional, Chukwu, Chukwuma, additional, Maire De Bhailis, Aine, additional, Al Chalabi, Saif, additional, Hudson, Amy, additional, Gopu, Arun, additional, Wickens, Olivia, additional, Storrar, Joshua, additional, Wahba, Mona, additional, Lorde, Nathan, additional, Rony, Mohammad, additional, Griffin, Sian, additional, Latif, Farah, additional, Ali, Mohammad, additional, DaSilva, Louise, additional, Ayling-Smith, Jonathan, additional, Mahdi, Eamon, additional, Willcocks, Lisa, additional, Jones, Rachel, additional, Cheung, Chee Kay, additional, Selvaskandan, Haresh, additional, Pugh, Dan, additional, Sayer, Matthew, additional, Dhaun, Neeraj, additional, Chapman, Fiona, additional, Mark, Patrick, additional, Geddes, Colin, additional, McQuarrie, Emily, additional, Patel, Rajan, additional, Solomon, Laurence, additional, Ponnusamy, Arvind, additional, Morris, Adam, additional, Okoh, Pedro, additional, Floyd, Lauren, additional, Dhaygude, Ajay, additional, Leung, Janson, additional, Goldsmith, Christopher, additional, Pandya, Bhavna, additional, Tez, Didem, additional, Mikhail, Ashraf, additional, Brown, Karen, additional, Bucknall, Thomas, additional, Lambie, Mark, additional, Comunale, Roderick, additional, Brandon, Donald, additional, Martinez, Stacy, additional, Hall, Amanda, additional, Henderson, Amy, additional, Fearday, Aaron, additional, Douthit, Nicole, additional, Snow, Brian, additional, Silva, Arnold, additional, Sly, Cathylee, additional, Keller, Christopher, additional, Davidson, Robert, additional, Meng, Jerry, additional, Haws, Robert, additional, Kattamanchi, Siddhartha, additional, Mojarrab, Javad, additional, Pillai, Unnikrishnan, additional, Lafayette, Richard, additional, O'Shaughnessy, Michelle, additional, Kamal, Fahameedah, additional, Mehta, Kshama, additional, Baker, Bruce, additional, Ruiz, Mario, additional, Jyothinagaram, Praveena, additional, Peri, Usha, additional, Paxton, William, additional, Tumlin, James, additional, McGreal, Kerri, additional, McCarthy, Ellen, additional, Kimber, Cassandra, additional, Gautam, Archana, additional, Khalil, Kassem, additional, Nguyen, Viet, additional, Minasian, Raffi, additional, Arfaania, Dariush, additional, Daneshvari, Sam, additional, Zakari, Michel, additional, Patrikyan, Artashes, additional, Afsari, Rouzbeh, additional, Ayvazyan, Christine, additional, Fakih, Faisal, additional, Lagatta, Mark, additional, Rodriguez, Alfred, additional, Avella, Jorge Enrique Monroy, additional, Patak, Ramachandra, additional, Kadakia, Jigar, additional, Appel, Gerald, additional, Ahn, Wooin, additional, Nelson, Bradley, additional, Medina, Allyson, additional, Ahmad, Syeda, additional, Peleg, Yonatan, additional, Clement, Nisha, additional, Chiu, Ian, additional, Hendren, Elizabeth, additional, Bomback, Andrew, additional, Canetta, Pietro, additional, Spinowitz, Bruce, additional, Charytan, Chaim, additional, Parikh, Nishita, additional, Kuo, Sheng, additional, Raichoudhury, Ritesh, additional, Dobre, Mirela, additional, Negrea, Lavinia, additional, Padiyar, Aparna, additional, Jittirat, Arksarapuk, additional, Pradhan, Nishigandha, additional, Dhelaria, Ranjit, additional, Balamuthusamy, Saravanan, additional, Madhrira, Machaiah, additional, Powell, Thomas, additional, Lifland, Howard, additional, Bailey, Asha, additional, Ford Sightler, Sarah Ashley, additional, Suthar, Meera Patel, additional, Green, Heather, additional, Parikh, Samir, additional, Ayoub, Isabelle, additional, Almaani, Salem, additional, Contreras, Gabriel, additional, Fornoni, Alessia, additional, Drexler, Yelena, additional, Geara, Abdallah, additional, Sheridan, Brittany, additional, Coppock, Gaia, additional, Hogan, Jonathan, additional, Gonzalez, Carlos, additional, Bhadra, Shamik, additional, Chowdhury, Pradip, additional, Kyaw, Kay, additional, Tan, May, additional, Raakesh, Lathika, additional, Mendoza, Elder, additional, Viramontes, Veronica, additional, Chaudhry, Asghar, additional, Carbonell, Juan, additional, Gadh, Rajdeep, additional, Fernandez, Victor, additional, Kassem, Mohamad, additional, Jacob, Radu, additional, Wilder, Karen, additional, Newsome, Britt, additional, Klamm, Kathryn, additional, Suyumova, Irina, additional, Kooienga, Laura Ann, additional, Janko, Catherine, additional, Rizk, Dana, additional, Julian, Bruce, additional, Caster, Dawn, additional, Perez, Erika, additional, Garg, Gunjan, additional, Gowda, Nayan, additional, Udani, Suneel, additional, Mandayam, Sreedhar, additional, Workeneh, Biruh, additional, Assefi, Ali, additional, Greco, Barbara, additional, Germain, Michael, additional, Patel, Jusmin, additional, Quinn, Sarah, additional, Sullivan, James, additional, Glaze, Jeffrey, additional, Madonia, Phillip, additional, McMahon, Kellyn, additional, Giles, Harold, additional, Adler, Sharon, additional, and Dai, Tiane, additional

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2023
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