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411 results on '"Tsai, S J"'

2. Semimetalic graphene in a modulated electric potential

Author

Ho, J. H., Chiu, Y. H., Tsai, S. J., and Lin, M. F.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Soft Condensed Matter
Abstract

The $\pi$-electronic structure of graphene in the presence of a modulated electric potential is investigated by the tight-binding model. The low-energy electronic properties are strongly affected by the period and field strength. Such a field could modify the energy dispersions, destroy state degeneracy, and induce band-edge states. It should be noted that a modulated electric potential could make semiconducting graphene semimetallic, and that the onset period of such a transition relies on the field strength. There exist infinite Fermi-momentum states in sharply contrast with two crossing points (Dirac points) for graphene without external fields. The finite density of states (DOS) at the Fermi level means that there are free carriers, and, at the same time, the low DOS spectrum exhibits many prominent peaks, mainly owing to the band-edge states., Comment: 12pages, 5 figures

Published
2008
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8. Identifying the Common Genetic Basis of Antidepressant Response.

Author

Pain, O, Hodgson, K, Trubetskoy, V, Ripke, S, Marshe, VS, Adams, MJ, Byrne, EM, Campos, AI, Carrillo-Roa, T, Cattaneo, A, Als, TD, Souery, D, Dernovsek, MZ, Fabbri, C, Hayward, C, Henigsberg, N, Hauser, J, Kennedy, JL, Lenze, EJ, Lewis, G, Müller, DJ, Martin, NG, Mulsant, BH, Mors, O, Perroud, N, Porteous, DJ, Rentería, ME, Reynolds, CF, Rietschel, M, Uher, R, Wigmore, EM, Maier, W, Wray, NR, Aitchison, KJ, Arolt, V, Baune, BT, Biernacka, JM, Bondolfi, G, Domschke, K, Kato, M, Li, QS, Liu, Y-L, Serretti, A, Tsai, S-J, Turecki, G, Weinshilboum, R, GSRD Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, McIntosh, AM, Lewis, CM, Pain, O, Hodgson, K, Trubetskoy, V, Ripke, S, Marshe, VS, Adams, MJ, Byrne, EM, Campos, AI, Carrillo-Roa, T, Cattaneo, A, Als, TD, Souery, D, Dernovsek, MZ, Fabbri, C, Hayward, C, Henigsberg, N, Hauser, J, Kennedy, JL, Lenze, EJ, Lewis, G, Müller, DJ, Martin, NG, Mulsant, BH, Mors, O, Perroud, N, Porteous, DJ, Rentería, ME, Reynolds, CF, Rietschel, M, Uher, R, Wigmore, EM, Maier, W, Wray, NR, Aitchison, KJ, Arolt, V, Baune, BT, Biernacka, JM, Bondolfi, G, Domschke, K, Kato, M, Li, QS, Liu, Y-L, Serretti, A, Tsai, S-J, Turecki, G, Weinshilboum, R, GSRD Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, McIntosh, AM, and Lewis, CM

Abstract

BACKGROUND: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of previous genome-wide association studies has been limited by sample size. This study performs the largest genetic analysis of prospectively assessed antidepressant response in major depressive disorder to gain insight into the underlying biology and enable out-of-sample prediction. METHODS: Genome-wide analysis of remission (n remit = 1852, n nonremit = 3299) and percentage improvement (n = 5218) was performed. Single nucleotide polymorphism-based heritability was estimated using genome-wide complex trait analysis. Genetic covariance with eight mental health phenotypes was estimated using polygenic scores/AVENGEME. Out-of-sample prediction of antidepressant response polygenic scores was assessed. Gene-level association analysis was performed using MAGMA and transcriptome-wide association study. Tissue, pathway, and drug binding enrichment were estimated using MAGMA. RESULTS: Neither genome-wide association study identified genome-wide significant associations. Single nucleotide polymorphism-based heritability was significantly different from zero for remission (h 2 = 0.132, SE = 0.056) but not for percentage improvement (h 2 = -0.018, SE = 0.032). Better antidepressant response was negatively associated with genetic risk for schizophrenia and positively associated with genetic propensity for educational attainment. Leave-one-out validation of antidepressant response polygenic scores demonstrated significant evidence of out-of-sample prediction, though results varied in external cohorts. Gene-based analyses identified ETV4 and DHX8 as significantly associated with antidepressant response. CONCLUSIONS: This study demonstrates that antidepressant response is influenced by common genetic variation, has a genetic overlap sc

Published
2022

17. COVID-19: Time for precision epidemiology

Author

Kõks, S., Williams, R.W., Quinn, J., Farzaneh, F., Conran, N., Tsai, S-J, Awandare, G., Goodman, S.R., Kõks, S., Williams, R.W., Quinn, J., Farzaneh, F., Conran, N., Tsai, S-J, Awandare, G., and Goodman, S.R.

Abstract

The global COVID-19 (SARS-CoV2, COVID-19) tsunami caused by SARSCoV2 is inundating and often-overwhelming health care systems in most countries and regions...

Published
2020

19. Erratum: The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response

Author

Biernacka, J M, Sangkuhl, K, Jenkins, G, Whaley, R M, Barman, P, Batzler, A, Altman, R B, Arolt, V, Brockmöller, J, Chen, C H, Domschke, K, Hall-Flavin, D K, Hong, C J, Illi, A, Ji, Y, Kampman, O, Kinoshita, T, Leinonen, E, Liou, Y J, Mushiroda, T, Nonen, S, Skime, M K, Wang, L, Baune, B T, Kato, M, Liu, Y L, Praphanphoj, V, Stingl, J C, Tsai, S J, Kubo, M, Klein, T E, and Weinshilboum, R

Published
2016
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39. Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder

Author

Amare, AT, Schubert, KO, Tekola-Ayele, F, Hsu, Y-H, Sangkuhl, K, Jenkins, G, Whaley, RM, Barman, P, Batzler, A, Altman, RB, Arolt, V, Brockmoeller, J, Chen, C-H, Domschke, K, Hall-Flavin, DK, Hong, C-J, Illi, A, Ji, Y, Kampman, O, Kinoshita, T, Leinonen, E, Liou, Y-J, Mushiroda, T, Nonen, S, Skime, MK, Wang, L, Kato, M, Liu, Y-L, Praphanphoj, V, Stingl, JC, Bobo, WV, Tsai, S-J, Kubo, M, Klein, TE, Weinshilboum, RM, Biernacka, JM, Baune, BT, Amare, AT, Schubert, KO, Tekola-Ayele, F, Hsu, Y-H, Sangkuhl, K, Jenkins, G, Whaley, RM, Barman, P, Batzler, A, Altman, RB, Arolt, V, Brockmoeller, J, Chen, C-H, Domschke, K, Hall-Flavin, DK, Hong, C-J, Illi, A, Ji, Y, Kampman, O, Kinoshita, T, Leinonen, E, Liou, Y-J, Mushiroda, T, Nonen, S, Skime, MK, Wang, L, Kato, M, Liu, Y-L, Praphanphoj, V, Stingl, JC, Bobo, WV, Tsai, S-J, Kubo, M, Klein, TE, Weinshilboum, RM, Biernacka, JM, and Baune, BT

Abstract

Studies reported a strong genetic correlation between the Big Five personality traits and major depressive disorder (MDD). Moreover, personality traits are thought to be associated with response to antidepressants treatment that might partly be mediated by genetic factors. In this study, we examined whether polygenic scores (PGSs) derived from the Big Five personality traits predict treatment response and remission in patients with MDD who were prescribed selective serotonin reuptake inhibitors (SSRIs). In addition, we performed meta-analyses of genome-wide association studies (GWASs) on these traits to identify genetic variants underpinning the cross-trait polygenic association. The PGS analysis was performed using data from two cohorts: the Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS, n = 529) and the International SSRI Pharmacogenomics Consortium (ISPC, n = 865). The cross-trait GWAS meta-analyses were conducted by combining GWAS summary statistics on SSRIs treatment outcome and on the personality traits. The results showed that the PGS for openness and neuroticism were associated with SSRIs treatment outcomes at p < 0.05 across PT thresholds in both cohorts. A significant association was also found between the PGS for conscientiousness and SSRIs treatment response in the PGRN-AMPS sample. In the cross-trait GWAS meta-analyses, we identified eight loci associated with (a) SSRIs response and conscientiousness near YEATS4 gene and (b) SSRI remission and neuroticism eight loci near PRAG1, MSRA, XKR6, ELAVL2, PLXNC1, PLEKHM1, and BRUNOL4 genes. An assessment of a polygenic load for personality traits may assist in conjunction with clinical data to predict whether MDD patients might respond favorably to SSRIs.

Published
2018

43. Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression

Author

Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C. -C, Wang, X., Zhang, J., Lin, W., Zheng, Lirong, Pu, J., Tsai, S. -J, Yang, A. C., Lin, C. -P, Wang, F., Xie, P., Feng, J., Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C. -C, Wang, X., Zhang, J., Lin, W., Zheng, Lirong, Pu, J., Tsai, S. -J, Yang, A. C., Lin, C. -P, Wang, F., Xie, P., and Feng, J.

Abstract

The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients with major depressive disorder and 488 control subjects. Resting state functional connectivity between different voxels reflects correlations of activity between those voxels and is a fundamental tool in helping to understand the brain regions with altered connectivity and function in depression. One major circuit with altered functional connectivity involved the medial orbitofrontal cortex Brodmann area 13, which is implicated in reward, and which had reduced functional connectivity in depression with memory systems in the parahippocampal gyrus and medial temporal lobe, especially involving the perirhinal cortex Brodmann area 36 and entorhinal cortex Brodmann area 28. The Hamilton Depression Rating Scale scores were correlated with weakened functional connectivity of the medial orbitofrontal cortex Brodmann area 13. Thus in depression there is decreased reward-related and memory system functional connectivity, and this is related to the depressed symptoms. The lateral orbitofrontal cortex Brodmann area 47/12, involved in non-reward and punishing events, did not have this reduced functional connectivity with memory systems. Second, the lateral orbitofrontal cortex Brodmann area 47/12 had increased functional connectivity with the precuneus, the angular gyrus, and the temporal visual cortex Brodmann area 21. This enhanced functional connectivity of the non-reward/punishment system (Brodmann area 47/12) with the precuneus (involved in the sense of self and agency), and the angular gyrus (involved in language) is thus related to the explicit affectively negative sense of the self, and of self-esteem, in depression. A comparison of the functional connectivity in 185 depressed patients not receiving medication and 182 patients receiving medication showed that the functional connectivity of the lateral orbitofrontal cortex Brodmann area, Export Date: 22 May 2017; Article; CODEN: BRAIA; Correspondence Address: Lin, C.-P.; Institute of Neuroscience, National Yang-Ming UniversityTaiwan; email: cplin@ym.edu.tw; Funding details: 11101429, NSFC, National Natural Science Foundation of China; Funding details: 11322111, NSFC, National Natural Science Foundation of China; Funding details: 11471081, NSFC, National Natural Science Foundation of China; Funding details: 2015M572423, China Postdoctoral Science Foundation; Funding details: 31271087, NSFC, National Natural Science Foundation of China; Funding details: 31271189, NSFC, National Natural Science Foundation of China; Funding details: 31470981, NSFC, National Natural Science Foundation of China; Funding details: 31500885, NSFC, National Natural Science Foundation of China; Funding details: 31571137, NSFC, National Natural Science Foundation of China; Funding details: 61104143, NSFC, National Natural Science Foundation of China; Funding details: 61273014, NSFC, National Natural Science Foundation of China; Funding details: 61573107, NSFC, National Natural Science Foundation of China; Funding details: 71661167002, NSFC, National Natural Science Foundation of China; Funding details: 81571331, NSFC, National Natural Science Foundation of China; Funding details: 91230201, CAS, Chinese Academy of Sciences; Funding details: 91230201, NSFC, National Natural Science Foundation of China; Funding details: AS-104-TP-B10, Academia Sinica; Funding details: cstc2015jcyjA10106, Natural Science Foundation of Chongqing; Funding details: DOH102-TD-PB-111-NSC006, MOHW, Ministry of Health and Welfare; Funding details: MOST 104-2218-E-010-007-MY3, MOST, Ministry of Science and Technology of the People's Republic of China; Funding details: MOST 104-2221-E-010-013, MOST, Ministry of Science and Technology of the People's Republic of China; Funding details: MOST 104-2633-B-400-001, MOST, Ministry of Science and Technology of the People's Republic of China; Funding details: NHR

Published
2016
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45. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response

Author

Biernacka, J M, primary, Sangkuhl, K, additional, Jenkins, G, additional, Whaley, R M, additional, Barman, P, additional, Batzler, A, additional, Altman, R B, additional, Arolt, V, additional, Brockmöller, J, additional, Chen, C H, additional, Domschke, K, additional, Hall-Flavin, D K, additional, Hong, C J, additional, Illi, A, additional, Ji, Y, additional, Kampman, O, additional, Kinoshita, T, additional, Leinonen, E, additional, Liou, Y J, additional, Mushiroda, T, additional, Nonen, S, additional, Skime, M K, additional, Wang, L, additional, Baune, B T, additional, Kato, M, additional, Liu, Y L, additional, Praphanphoj, V, additional, Stingl, J C, additional, Tsai, S J, additional, Kubo, M, additional, Klein, T E, additional, and Weinshilboum, R, additional

Published
2015
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48. Endometriosis, endometrium, implantation and fallopian tube

Author

Tan, C. W., primary, Lee, Y. H., additional, Choolani, M., additional, Tan, H. H., additional, Griffith, L., additional, Chan, J., additional, Chuang, P. C., additional, Wu, M. H., additional, Lin, Y. J., additional, Tsai, S. J., additional, Rahmati, M., additional, Petitbarat, M., additional, Dubanchet, S., additional, Bensussan, A., additional, Chaouat, G., additional, Ledee, N., additional, Bissonnette, L., additional, Haouzi, D., additional, Monzo, C., additional, Traver, S., additional, Bringer, S., additional, Faidherbe, J., additional, Perrochia, H., additional, Ait-Ahmed, O., additional, Dechaud, H., additional, Hamamah, S., additional, Ibrahim, M. G., additional, de Arellano, M. L. B., additional, Sachtleben, M., additional, Chiantera, V., additional, Frangini, S., additional, Younes, S., additional, Schneider, A., additional, Plendl, J., additional, Mechsner, S., additional, Ono, M., additional, Hamai, H., additional, Chikawa, A., additional, Teramura, S., additional, Takata, R., additional, Sugimoto, T., additional, Iwahashi, K., additional, Ohhama, N., additional, Nakahira, R., additional, Shigeta, M., additional, Park, I. H., additional, Lee, K. H., additional, Sun, H. G., additional, Kim, S. G., additional, Lee, J. H., additional, Kim, Y. Y., additional, Kim, H. J., additional, Jeon, G. H., additional, Kim, C. M., additional, Bocca, S., additional, Wang, H., additional, Anderson, S., additional, Yu, L., additional, Horcajadas, J., additional, Oehninger, S., additional, Bastu, E., additional, Mutlu, M. F., additional, Celik, C., additional, Yasa, C., additional, Dural, O., additional, Buyru, F., additional, Quintana, F., additional, Cobo, A., additional, Remohi, J., additional, Ferrando, M., additional, Matorras, R., additional, Bermejo, A., additional, Iglesias, C., additional, Cerrillo, M., additional, Ruiz, M., additional, Blesa, D., additional, Simon, C., additional, Garcia-Velasco, J. A., additional, Chamie, L., additional, Ribeiro, D. M. F., additional, Riboldi, M., additional, Pereira, R., additional, Rosa, M. B., additional, Gomes, C., additional, de Mello, P. H., additional, Fettback, P., additional, Domingues, T., additional, Cambiaghi, A., additional, Soares, A. C. P., additional, Kimati, C., additional, Motta, E. L. A., additional, Serafini, P., additional, Hapangama, D. K., additional, Valentijn, A. J., additional, Al-Lamee, H., additional, Palial, K., additional, Drury, J. A., additional, von Zglinicki, T., additional, Saretzki, G., additional, Gargett, C. E., additional, Liao, C. Y., additional, Sung, Y. J., additional, Li, H. Y., additional, Morotti, M., additional, Remorgida, V., additional, Venturini, P. L., additional, Ferrero, S., additional, Nabeta, M., additional, Iki, A., additional, Hashimoto, H., additional, Koizumi, M., additional, Matsubara, Y., additional, Hamada, K., additional, Fujioka, T., additional, Matsubara, K., additional, Kusanagi, Y., additional, Nawa, A., additional, Zanatta, A., additional, da Rocha, A. M., additional, Guerra, J. L., additional, Cogliati, B., additional, Bianchi, P. d. M., additional, Prieto, B., additional, Exposito, A., additional, Mendoza, R., additional, Rabanal, A., additional, Bedaiwy, M., additional, Yi, L., additional, Dahoud, W., additional, Liu, J., additional, Hurd, W., additional, Falcone, T., additional, Biscotti, C., additional, Mesiano, S., additional, Sugiyama, R., additional, Nakagawa, K., additional, Nishi, Y., additional, Kuribayashi, Y., additional, Akira, S., additional, Germeyer, A., additional, Rosner, S., additional, Jauckus, J., additional, Strowitzki, T., additional, von Wolff, M., additional, Khan, K. N., additional, Kitajima, M., additional, Fujishita, A., additional, Nakashima, M., additional, Masuzaki, H., additional, Kajihara, T., additional, Ishihara, O., additional, Brosens, J., additional, Vezmar, K., additional, Savournin, V., additional, Balet, R., additional, Loh, S. F., additional, Tannenbaum, S. R., additional, Chan, J. K. Y., additional, Scarella, A., additional, Chamy, V., additional, Devoto, L., additional, Abrao, M., additional, Sovino, H., additional, Krasnopolskaya, K., additional, Popov, A., additional, Kabanova, D., additional, Beketova, A., additional, Ivakhnenko, V., additional, Shohayeb, A., additional, Wahba, A., additional, Abousetta, A., additional, al-inany, H., additional, El Daly, A., additional, Zayed, M., additional, Kvaskoff, M., additional, Han, J., additional, Missmer, S. A., additional, Navarro, P., additional, Meola, J., additional, Ribas, C. P., additional, Paz, C. P., additional, Ferriani, R. A., additional, Donabela, F. C., additional, Tafi, E., additional, Maggiore, U. L. R., additional, Scala, C., additional, Hackl, J., additional, Strehl, J., additional, Wachter, D., additional, Dittrich, R., additional, Cupisti, S., additional, Hildebrandt, T., additional, Lotz, L., additional, Attig, M., additional, Hoffmann, I., additional, Renner, S., additional, Hartmann, A., additional, Beckmann, M. W., additional, Urquiza, F., additional, Ferrer, C., additional, Incera, E., additional, Azpiroz, A., additional, Junovich, G., additional, Pappalardo, C., additional, Guerrero, G., additional, Pasqualini, S., additional, Gutierrez, G., additional, Corti, L., additional, Sanchez, A. M., additional, Bordignon, P. P., additional, Santambrogio, P., additional, Levi, S., additional, Persico, P., additional, Vigano, P., additional, Papaleo, E., additional, Ferrari, S., additional, Candiani, M., additional, van der Houwen, L. E. E., additional, Schreurs, A. M. F., additional, Lambalk, C. B., additional, Schats, R., additional, Hompes, P. G. A., additional, Mijatovic, V., additional, Xu, S. Y., additional, Li, J., additional, Chen, X. Y., additional, Chen, S. Q., additional, Guo, L. Y., additional, Mathew, D., additional, Nunes, Q., additional, Lane, B., additional, Fernig, D., additional, Hapangama, D., additional, Lind, T., additional, Hammarstrom, M., additional, Golmann, D., additional, Rodriguez-Wallberg, K., additional, Hestiantoro, A., additional, Cakra, A., additional, Aulia, A., additional, Al-Inany, H., additional, Houston, B., additional, Farquhar, C., additional, Tagliaferri, V., additional, Gagliano, D., additional, Immediata, V., additional, Tartaglia, C., additional, Zumpano, A., additional, Campagna, G., additional, Lanzone, A., additional, Guido, M., additional, Matsuzaki, S., additional, Darcha, C., additional, Botchorishvili, R., additional, Pouly, J. L., additional, Mage, G., additional, Canis, M., additional, Shivhare, S. B., additional, Bulmer, J. N., additional, Innes, B. A., additional, Lash, G. E., additional, de Graaff, A. A., additional, Zandstra, H., additional, Smits, L. J., additional, Van Beek, J. J., additional, Dunselman, G. A. J., additional, Bozdag, G., additional, Calis, P. T., additional, Demiralp, D. O., additional, Ayhan, B., additional, Igci, N., additional, Yarali, H., additional, Acar, N., additional, Er, H., additional, Ozmen, A., additional, Ustunel, I., additional, Korgun, E. T., additional, Kuroda, K., additional, Kuroda, M., additional, Arakawa, A., additional, Kitade, M., additional, Brosens, A. I., additional, Brosens, J. J., additional, Takeda, S., additional, and Yao, T., additional

Published
2013
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