25 results on '"Tsai, Pei-Chen"'
Search Results
2. Solid‐phase Synthesis of Peptidols via Reductive Cleavage through a Benzotriazole Linker
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Chen, Szu-Hsuan, primary, Chuang, Hui-Ying, additional, Rajavel, Chitra, additional, Lin, Yi Kai, additional, Chang, Shu-Han, additional, Tsai, Pei-Chen, additional, Chen, Hui-Ting, additional, SUN, Chung-Ming, additional, Selvaraj, Anand, additional, and kao, Chai-Lin, additional
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- 2024
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3. Ambient temperature and the occurrence of intradialytic hypotension in patients receiving hemodialysis
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Liu, Kuan-Hung, primary, Chang, Wei-Hsiang, additional, Lai, Edward Chia-Cheng, additional, Tsai, Pei-Chen, additional, Hsu, Bin, additional, Yang, Yu-Hsuan, additional, Lin, Wei-Ren, additional, Huang, Tzu-Shan, additional, Su, Fang-Yi, additional, Chiang, Jung-Hsien, additional, Li, Chung-Yi, additional, Tsai, Yau-Sheng, additional, and Sung, Junne-Ming, additional
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- 2023
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4. To the light side: molecular diversity and morphology of stomatopod larvae and juveniles (Crustacea: Malacostraca: Stomatopoda) from crustose coralline algal reefs in Taiwan
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Wong, Kingsley J. H., Tsao, Yao-Feng, Tsai, Pei-Chen, Hsieh, Wei-Peng, Li, Han-Ru, Machida, Ryuji J., and Chan, Benny K. K.
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- 2021
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5. Ambient temperature and the occurrence of intradialytic hypotension in patients receiving hemodialysis.
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Liu, Kuan-Hung, Chang, Wei-Hsiang, Lai, Edward Chia-Cheng, Tsai, Pei-Chen, Hsu, Bin, Yang, Yu-Hsuan, Lin, Wei-Ren, Huang, Tzu-Shan, Su, Fang-Yi, Chiang, Jung-Hsien, Li, Chung-Yi, Tsai, Yau-Sheng, and Sung, Junne-Ming
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HEMODIALYSIS ,GENERALIZED estimating equations ,HEMODIALYSIS patients ,HYPOTENSION ,DISEASE risk factors ,BLOOD pressure ,SEASONAL variations of diseases - Abstract
Background Intradialytic hypotension (IDH) is a common hemodialysis complication causing adverse outcomes. Despite the well-documented associations of ambient temperatures with fluid removal and pre-dialysis blood pressure (BP), the relationship between ambient temperature and IDH has not been adequately studied. Methods We conducted a cohort study at a tertiary hospital in southern Taiwan between 1 January 2016 and 31 October 2021. The 24-h pre-hemodialysis mean ambient temperature was determined using hourly readings from the weather station closest to each patient's residence. IDH was defined using Fall40 [systolic BP (SBP) drop of ≥40 mmHg] or Nadir90/100 (SBP <100 if pre-dialysis SBP was ≥160, or SBP <90 mmHg). Multivariate logistic regression with generalizing estimating equations and mediation analysis were utilized. Results The study examined 110 400 hemodialysis sessions from 182 patients, finding an IDH prevalence of 11.8% and 10.4% as per the Fall40 and Nadir90/100 criteria, respectively. It revealed a reverse J-shaped relationship between ambient temperature and IDH, with a turning point around 27°C. For temperatures under 27°C, a 4°C drop significantly increased the odds ratio of IDH to 1.292 [95% confidence interval (CI) 1.228 to 1.358] and 1.207 (95% CI 1.149 to 1.268) under the Fall40 and Nadir90/100 definitions, respectively. Lower ambient temperatures correlated with higher ultrafiltration, accounting for about 23% of the increased IDH risk. Stratified seasonal analysis indicated that this relationship was consistent in spring, autumn and winter. Conclusion Lower ambient temperature is significantly associated with an increased risk of IDH below the threshold of 27°C, irrespective of the IDH definition. This study provides further insight into environmental risk factors for IDH in patients undergoing hemodialysis. [ABSTRACT FROM AUTHOR]
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- 2024
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6. The mitochondrial genome of Isognomon nucleus and mitogenomics of pteriomorphia (Bivalvia: Autobranchia)
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Dreyer, Niklas, primary, de Mattos, Felipe Monteiro Gomes, additional, Jain, Dharmesh, additional, Fong, Chia-Ling, additional, De Vivo, Mattia, additional, Wen, Yung-Hui Victoria, additional, Huang, Yu-Hsin, additional, Mwihaki, John Karichu, additional, Lee, Hsin-Han, additional, Tsai, Pei-Chen, additional, Tsao, Yao-Feng, additional, Chan, Benny Kwok Kan, additional, Tsai, Isheng Jason, additional, Machida, Ryuji J, additional, Wang, Tzi-Yuan, additional, and Wang, John, additional
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- 2023
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7. The effect of diabetes and prediabetes on the prevalence, complications and mortality in nonalcoholic fatty liver disease
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Ng, Cheng Han, primary, Chan, Kai En, additional, Chin, Yip Han, additional, Zeng, Rebecca Wenling, additional, Tsai, Pei Chen, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Khoo, Chin Meng, additional, Goh, Lay Hoon, additional, Ling, Zheng Jye, additional, Kulkarni, Anand, additional, Mak, Lung-Yi Loey, additional, Huang, Daniel Q, additional, Chan, Mark, additional, Chew, Nicholas WS, additional, Siddiqui, Mohammad Shadab, additional, Sanyal, Arun J., additional, and Muthiah, Mark, additional
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- 2022
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8. Comparison between the Catch Composition of the French and Ore type Beam Trawls on Deep-Sea Decapod Crustaceans: Implications for Quantitative Sampling of the Deep-Sea Decapod Biodiversity
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Tsai, Pei-Chen, Yeh, Hsin-Ming, Chan, Benny Kwok Kan, and Chan, Tin-Yam
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- 2009
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9. Effect of media reporting of the suicide of a singer in Taiwan: the case of Ivy Li
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Chen, Ying-Yeh, Tsai, Pei-Chen, Chen, Pao-Huan, Fan, Chun-Chieh, Hung, Galen Chin-Lun, and Cheng, Andrew T. A.
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- 2010
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10. Developing a Value Model of Wellness Service
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Tsai, Pei-Chen, Deng, Yi-Shin, and You, Hsiao-Chen
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Wellness ,Service Design ,Value Models - Abstract
The aim of this study was to develop a value model of wellness service. In this study, those persons who work in health care systems were recruited to participate in interviews for investigating the value of various roles and the effects of these values between the roles. Throughout this study, the flow model, sequence model and cultural model were established to explain the relationship between the different roles, the process being influenced by others, and the effects of other values in wellness-related activities. According to the models, the following features of value in wellness activities could be found: personal, interactive and temporal. Based on the result of this study, the investigating and presenting the relevance of effects between values more completely will be researched in the next study.
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- 2020
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11. Normal pressure hydrocephalus presenting as psychotic symptoms: A case report
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Cheng, Ying-Chih, primary, Lin, Chia-Heng, additional, Tsai, Pei-Chen, additional, and Huang, Ying-Hsi, additional
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- 2020
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12. High-dose disulfiram-induced delirium and manic features: A case report
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Cheng, Ying-Chih, primary, Lin, Yun, additional, and Tsai, Pei-Chen, additional
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- 2020
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13. A framework of a stakeholders' value exchange model and a paradigm of practice
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Chuang, Ming Chuen, primary, Tsai, Pei Chen, additional, and Deng, Yi Shin, additional
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- 2017
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14. A framework of a stakeholders' value exchange model and a paradigm of practice
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Tsai, Pei Chen, primary, Deng, Yi Shin, additional, and Chuang, Ming Chuen, additional
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- 2017
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15. Association between dopamine D2 receptor (DRD2) genetic variants and alcohol dependence in Han Chinese in Taiwan
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Tsai, Pei-Chen, primary, Chen, Chaio-Chicy, additional, Pan, Chun-Hung, additional, Jan, Wen-Chi, additional, Kuo, Po-Hsiu, additional, and Huang, Ming-Chyi, additional
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- 2014
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16. Tetraclita reni Chan, Hsu & Tsai
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Chan, Benny Kwok Kan, Hsu, Chih-Hsiung, and Tsai, Pei-Chen
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Tetraclitidae ,Arthropoda ,Animalia ,Biodiversity ,Tetraclita ,Maxillopoda ,Sessilia ,Tetraclita reni ,Taxonomy - Abstract
Tetraclita reni Chan, Hsu & Tsai nom. nov. Figures 2 A, 2 D, 3 A���C, 4, 5 Tetraclita squamosa rufotincta Utinomi, 1968: 180 (Cape Diego, Madagascar) Tetraclita africana Ren, 1989: 452, 453, fig. 12 (Sainte Luce, Madagascar, type locality) Material examined. Cape Diego, Madagascar (Galathea stn. 223), ZMUC CRU- 9881, Tetraclita squamosa rufotincta (3 specimens), 03-March- 1951, det. Utinomi 1967; Connoniers Point, Mauritius, ZMUC CRU- 9882, Tetraclita squamosa rufotincta (2 specimens), 30 -April- 1929, coll. Th. Mortensen; Ambovombe, Madagascar, MNHN Entr��e no. 7, Tetraclita (1 specimen), 1931, coll. D. de M. R. Decary; Sarodrano, Madagascar, MNHN C.l. 664, Tetraclita porosa rufotincta (2 specimens), 1906, coll. F. Geay; Fort Dauphin, Madagascar, MNHN, Tetraclita porosa (1 specimen), 1901, coll. Ferlus. Description. Parietes pink, surfaces of some older specimens with white patches due to erosion. Posterior side of scutum and tergum varying from pink to white. Terga from majority of samples with wide base, rounded spur (Fig. 2 A); mean basi-scutal angle 140 �� 8.6 o (n = 6, pooled specimens from Cape Diego, Fort Dauphin and Amobvombe; Fig. 2 A); scutal margin long, lateral depressor muscle crests 6���8. Scutum triangular, large teeth on occludent margin (Fig. 2 A), tergal margin long; adductor muscle scar deep; depressor muscles crests well developed with 6���9 crests; adductor ridge short (Fig. 2 A). Rami of cirrus I unequal (Fig. 3 A, 4 A); exopodite (18 segments, Mauritius sample) longer than endopodite (12 segments, Mauritius sample; Fig. 3 A). Cirrus II shortest of cirri, rami approximately equal (exopodite 12 segments, endopodite 11 segments, Mauritius sample, Fig. 3 B). Setae on rami of cirrus I and II serrulate with 3���4 rows of setules (Fig. 4 A, B, D���F); coxa and base of protopod of cirrus I bearing long, thin, serrulate setae with 5 short setules (Fig. 3 A, 4 A, F), those of cirrus II bearing plumose setae with long feathery setules (Fig. 3 B, 4 B, G); cirrus II additionally bearing flattened, blade-shaped, serrulate setae, each with single row of setules (Fig. 4 H). cirrus III with rami long,slender, somewhat antenniform (Fig. 3 C, 4 C); exopodite (15 segments) shorter than endopodite (24 segments; Mauritius sample, Fig. 3 C). Setae on rami of cirrus III similar to those on cirrus II (Fig. 4 C) plus additional dense, serrulate setae (Fig. 4 E), bidentate, serrate setae (Fig. 2 C, 4 L), bladeshaped serrulate setae (Fig. 4 H) and large multicuspidate setae (Fig. 2 D, 4 I); setules and inter-setule space of multicuspidate setae larger than those of bidentate serrate setae (Fig. 2 C, D, 4 I, L). Cirri IV, V and VI similar, all bearing serrulate setae with 1 row of setules (Fig. 4 M, O); simple setae present on segment junctions of cirri IV���VI (Fig. 4 N, O). Labrum notch slightly concave, with 4���5 teeth on each side (Fig. 5 A, B); posterior surface densely clothed in serrulate setae (Fig. 5 C). Mandible with four teeth, lower angle with ~ 10 small setae (Fig. 5 D���F). Maxillule notched, two large setae on upper notch, 16 on lower notch (Fig. 5 I). Mandibulatory palp oval, long serrulate setae distally (Fig. 5 K, L). Maxilla bi-lobed, covered with dense, serrulate setae, notch between the lobes non-setose (Fig. 5 G, H). Diagnosis. Tetraclita reni nom. nov. is characterized by the multicuspidate setae on cirrus III, which are not seen in other species of Tetraclita except T. japonica Pilsbry 1916, a Pacific species (Ren 1989; Chan 2001). Distribution. Northeastern and southern Madagascar and Mauritius. Remarks. Ren (1989) described a new species of Tetraclita from Madagascar with the epithet africana, which was preoccupied by Tetraclita wireni africana (Nilsson-Cantell 1932). Tetraclita wireni was later assigned to Tesseropora (see Newman & Ross 1976). As Tetraclita africana Ren 1989 is a junior homonym of Tetraclita wireni africana Nilsson-Cantell 1932, Tetraclita reni nom. nov. is erected for the species described by Ren (1989). The present study provides new records of T. reni nom. nov. in southern and northeastern Madagascan waters and Mauritius. Etymology. Tetraclita reni nom. nov. is named in honour of Professor Xianqiu Ren, Institute of Oceanology, Chinese Academy of Science, in recognition of his discovery of this new species (= T. africana) and for his contributions in the field of Chinese barnacle taxonomy., Published as part of Chan, Benny Kwok Kan, Hsu, Chih-Hsiung & Tsai, Pei-Chen, 2009, Morphology and distribution of the acorn barnacle Tetraclita reni nom. nov. (Crustacea: Cirripedia) in Madagascar and adjacent waters, pp. 57-68 in Zootaxa 2019 on pages 59-60, DOI: 10.5281/zenodo.186037, {"references":["Utinomi, H. (1968) Pelagic, shelf and shallow-water cirripedia from the Indo-west Pacific. Videnskalelige Meddelelser fra Dansk Naturhistorisk Forening I Kobenhaven, 131, 161 - 186.","Ren, X. (1989) On a collection of Cirripedia Thoracica from Madagascar and adjacent waters. Bulletin of the Museum national d'Histoire naturelle, Paris, 4 e ser section A, 2, 431 - 468.","Pilsbry, H. A. (1916) The sessile barnacles (Cirripedia) contained in the collection of the U. S. National Museum: including a monograph of the American species. Bulletin of the United States National Museum, 93, 241 - 353.","Chan, B. K. K. (2001) Studies on Tetraclita squamosa and Tetraclita japonica (Cirripedia Thoracica) I: Adult morphology. Journal of Crustacean Biology, 21, 616 - 630.","Nilsson-Cantell, C. A. (1932) Neue Balaniden aus Sud- and Ost-Afrika in dem Berliner Museum. Arkiv fur Zoologi, 24 A, 1 - 18.","Newman, W. A. & Ross, A. (1976) Revision of the balanomorph barnacles; including a catalogue of the species. Memoir of the San Diego Society of Natural History, 9, 1 - 108."]}
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- 2009
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17. Tetraclita rufotincta Pilsbry 1916
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Chan, Benny Kwok Kan, Hsu, Chih-Hsiung, and Tsai, Pei-Chen
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Tetraclitidae ,Arthropoda ,Animalia ,Biodiversity ,Tetraclita ,Maxillopoda ,Sessilia ,Tetraclita rufotincta ,Taxonomy - Abstract
Tetraclita rufotincta Pilsbry, 1916 Figures 2 B, 2 C, 3 D���F, 6, 7 Tetraclita squamosa rufotincta Pilsbry, 1916: 253 ���254, pl. 58, figs. 5���6 a (Gulf of Aden-type locality). Tetraclita porosa rufotincta��� Nilsson-Cantell, 1928: 35, fig. 16 (Muscat, Gulf of Oman). Tetraclita squamosa rufotincta��� Utinomi, 1969: 92 (Nabiyu Tunb, Strait of Hormuz). Tetraclita rufotincta. - Ross, 1999 (Red Sea). Material examined. South Yemen, MNHN, Paris, Tetraclita rufotincta (3 specimens), det Diana Jones; Islet east of Shimoni, Kenya, NHM, London, Tl 978. 370 - 379, Tetraclita rufotincta (2 specimens), 20 -November- 1971, coll, J.D. Taylor, det A.J. Southward; Aldabra, Indian Ocean, NHM, London, 1978.47, Tetraclita sp. (3 specimens), Dune Jean Louis, 16 -August- 1973, coll. J.D. Taylor; Lontide Muscat (Gulf of Oman), NHM, London, 1902.12.8.3��� 8, Tetraclita porosa var rufotincta (4 specimens); Kosi Bay, Mozambique, NHM, London, 1967. 3. 14.31, Tetraclita rufotincta (1 specimen), coll. 13.7. 49, University of Cape Town, Ecological Survey; Madagascar (Nossy-Kousba), MNHN, Paris, Tetraclita squamosa rufotincta (1 specimen), 1991, coll. Joly; Tanikely, Madagascar, MNHN, Paris, CI 674, CI 675, Tetraclita rufotincta (3 specimens), 1 - April- 1960. Description. Parietes pink, surfaces of some older specimens with white patches due to erosion. Posterior side of scutum and tergum varying from pink to white. Tergum spur sharp (Fig. 2 B); mean basi-scutal angle 110 �� 13 �� (n = 6, pooled specimens from Aldabra, Kenya and South Yemen); lateral depressor muscle crests 7���10. Scutum triangular, large teeth on occludent margin (Fig. 2 B); adductor muscle scar deep; depressor muscle crests 10���11. Cirrus I with rami unequal, exopodite (20 segments, Yemen sample) longer than endopodite (12 segments, Yemen sample; Fig. 3 D); rami (Fig. 6 A) bearing serrulate setae with 3 rows of setules (Fig. 6 D), feathery serrulate setae (Fig. 6 E) and blade-shaped serrulate setae with very short and sparse setules (Fig. 6 J); coxa and base of protopod with feathery serrulate setae (Fig. 6 F). Cirrus II shorter than cirrus I; exopodite (15 segments, Yemen sample) and endopodite (13 segments, Yemen sample) similar length (Fig. 3 E, 6 B). Setal types of cirrus II similar to cirrus I (Fig. 6 A, B), except blade-shaped setae with short, sparse setules absent (Fig. 6 J); coxa with plumose setae (Fig. 6 G). Cirrus III with exopodite (11 segments, Yemen sample) and endopodite (11 segments, Yemen sample) similar length (Fig. 3 F, 6 C); cirrus III exhibiting highest diversity of setal types (Fig. 6 C); setae on base and coxa of protopod plumose (Fig. 6 G) and serrulate (Fig. 6 F); rami with serrulate setae (Fig. 6 D, E, H), bidentata, serrate setae (Fig. 2 C, Fig. 6 I) and thick, bladeshaped, serrulate setae with short setules (Fig. 6 J). Rami of cirri IV, V, VI with serrulate setae, each with 1 row of setules (Fig. 6 K, L); segmental junctions with short, simple setae (Fig. 6 M). Labrum concave, 4���5 large teeth on each side of notch (Fig. 7 A, B); posterior side of labrum with serrulate setae (Fig. 7 C). Mandible with 4 teeth, 2 nd and 3 rd bidentate, 4 th tridentate (Fig. 7 D, E, F); lower angle with 5���6 small setae (Fig. 7 E). Maxillule notched, 2 large setae at upper notch, 8 setae on lower notch (Fig. 7 I, J). Mandibulatory palp oval (Fig. 7 G, H). Maxilla bilobed with long setae, notch between lobes non-setose (Fig. 7 K, L). Maxillule, mandibulatory palp and maxilla with serrulate setae(Fig. 7 J, K, L). Diagnosis. Tetraclita rufotincta can be distinguished from T. reni nom. nov. by the lack of multicuspidate setae on cirrus III, and the tergum with a sharper spur and a smaller basi-scutal angle when compared to T. reni nom. nov. Distribution. West coast of India (Mumbai), Gulf of Aden, Red Sea, East coast of Africa, NW Madagascar. Remarks. Tetraclita rufotincta is a widely distributed species in the West Indian Ocean. Pilsbry (1916) identified this species from Aden (type locality) and concluded specimens from Zanzibar, East Africa, were also T. rufotincta. Pilsbry (1916), however, noted there were intra-specific morphological variations between a Zanzibar specimen and the Aden specimens. The Zanzibar specimen had a tergum with a spur which was 'less deeply entered' (i.e. larger basi-scutal angle) and a straighter scutal margin, and a scutum with deeper articular furrows when compared to the Aden specimens. In the present study, Tetraclita rufotincta specimens from Aldabra appeared to have a larger basi-scutal angle (spur less deeply entered) than those from Kenya and Aden (Fig. 2 B). The setal types of cirri and mouth parts of these populations were similar. As there are no obvious diagnostic morphological variations between these populations, they are considered as T. rufotincta in the present study. However, since there are intra-specific morphological variations among geographical populations, it is likely that T. rufotincta contains a cryptic species complex in the West Indian Ocean. Further studies should be conducted on molecular analysis to compare the genetic differentiation of T. rufotincta in different geographical populations of the West Indian Ocean to further ascertain the taxonomic status of the barnacle from different geographical locations., Published as part of Chan, Benny Kwok Kan, Hsu, Chih-Hsiung & Tsai, Pei-Chen, 2009, Morphology and distribution of the acorn barnacle Tetraclita reni nom. nov. (Crustacea: Cirripedia) in Madagascar and adjacent waters, pp. 57-68 in Zootaxa 2019 on page 64, DOI: 10.5281/zenodo.186037, {"references":["Pilsbry, H. A. (1916) The sessile barnacles (Cirripedia) contained in the collection of the U. S. National Museum: including a monograph of the American species. Bulletin of the United States National Museum, 93, 241 - 353.","Nilsson-Cantell, C. A. (1928) Studies on cirripedes in the British Museum (Nat. Hist.). Annals and Magazine of the Natural History Museum, 2, 1 - 39.","Utinomi, H. (1969) Cirripedia of the Iranian Gulf. Videnskalelige Meddelelser fra Dansk Naturhistorisk Forening I Kobenhaven, 132, 79 - 94.","Ross, A. (1999) Studies on the Tetraclitidae (Cirripedia: Balanomorpha); new species of Tetraclita from the Red Sea. Pakistan Journal of Marine Science, 8, 41 - 53."]}
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- 2009
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18. Proposing a Values Exchange Model: A Service Design Tool for Interpretation of Values Patterns in a Wellness Context
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Tsai, Pei-Chen, primary, Deng, Yi-Shin, additional, and Chuang, Ming-Chuen, additional
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- 2013
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19. Taiwan’s Path to Innovative R&D and Applications: “Technology-Driven” and “Location-Driven” Pilot Programs
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Tsai, Pei-Chen, primary and Lin, Shang-Hui, additional
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- 2012
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20. A Case of Aripiprazole-Associated Paroxysmal Supraventricular Tachycardia
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Tsai, Pei-Chen, primary, Hsiao, Shih-Hung, additional, and Chiu, Chih-Chiang, additional
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- 2009
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21. Effect of media reporting of the suicide of a singer in Taiwan: the case of Ivy Li
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Chen, Ying-Yeh, primary, Tsai, Pei-Chen, additional, Chen, Pao-Huan, additional, Fan, Chun-Chieh, additional, Hung, Galen Chin-Lun, additional, and Cheng, Andrew T. A., additional
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- 2009
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22. Morphology and distribution of the acorn barnacle Tetraclita reni nom. nov. (Crustacea: Cirripedia) in Madagascar and adjacent waters
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CHAN, BENNY KWOK KAN, primary, HSU, CHIH-HSIUNG, additional, and TSAI, PEI-CHEN, additional
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- 2009
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23. Genetic Impacts on DNA methylation help elucidate regulatory genomic processes
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Villicana, Sergio, Castillo-Fernandez, Juan, Hannon, Ellis, Christiansen, Colette, Tsai, Pei-Chen, Maddock, Jane, Kuh, Diana, Suderman, Matthew, Power, Christine, Relton, Caroline, Ploubidis, George, Wong, Andrew, Hardy, Rebecca, Goodman, Alissa, Ong, Ken, Bell, Jordana, Villicana, Sergio, Castillo-Fernandez, Juan, Hannon, Ellis, Christiansen, Colette, Tsai, Pei-Chen, Maddock, Jane, Kuh, Diana, Suderman, Matthew, Power, Christine, Relton, Caroline, Ploubidis, George, Wong, Andrew, Hardy, Rebecca, Goodman, Alissa, Ong, Ken, and Bell, Jordana
- Abstract
Background: Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk. Results: We report heritability and methylation quantitative trait locus (meQTL) analysis at 724,499 CpGs profiled with the Illumina Infinium MethylationEPIC array in 2358 blood samples from three UK cohorts. Methylation levels at 34.2% of CpGs are affected by SNPs, and 98% of effects are cis-acting or within 1 Mbp of the tested CpG. Our results are consistent with meQTL analyses based on the former Illumina Infinium HumanMethylation450 array. Both SNPs and CpGs with meQTLs are overrepresented in enhancers, which have improved coverage on this platform compared to previous approaches. Co-localisation analyses across genetic effects on DNA methylation and 56 human traits identify 1520 co-localisations across 1325 unique CpGs and 34 phenotypes, including in disease-relevant genes, such as USP1 and DOCK7 (total cholesterol levels), and ICOSLG (inflammatory bowel disease). Enrichment analysis of meQTLs and integration with expression QTLs give insights into mechanisms underlying cis-meQTLs (e.g. through disruption of transcription factor binding sites for CTCF and SMC3) and trans-meQTLs (e.g. through regulating the expression of ACD and SENP7 which can modulate DNA methylation at distal sites). Conclusion: Our findings improve the characterisation of the mechanisms underlying DNA methylation variability and are informative for prioritisation of GWAS variants for functional follow-ups. The MeQTL EPIC Database and viewer are available online at https://epicmeqtl.kcl.ac.uk .
24. [The Effectiveness of a Mindfulness-Based Intervention in Reducing Relocation Anxiety and Promoting Adaptation in Older People With Diabetes].
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Tsai PC, Chen SM, Lin HS, and Chen YJ
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- Aged, Diabetes Mellitus epidemiology, Humans, Program Evaluation, Residential Facilities, Taiwan epidemiology, Adaptation, Psychological, Anxiety psychology, Diabetes Mellitus psychology, Mindfulness, Residence Characteristics
- Abstract
Background: Relocating from home to a long-term facility is frequently a stressful event for older persons with diabetes. Therefore, it is important that nurses have available an intervention program that effectively reduces relocation anxiety and promotes adaptation in this population., Purpose: To evaluate the effectiveness of a mindfulness-based intervention in reducing relocation anxiety and promoting adaptation in older persons with diabetes., Methods: Four long-term care facilities in Kaohsiung City were selected as the study sites. Residents of these facilities who had diabetes and who had moved in within the previous year were recruited as participants using a simple random-sampling method. The experimental group (n = 34) received a 9-week mindfulness-based intervention and the control group (n = 32) received routine diabetes care and maintained their normal daily routine. Outcome measurements included a demographic datasheet, the Taiwanese version of the State Anxiety Inventory, and the individual mental factors subscale of the elderly adaptation problem scale. These measures were administered at baseline and upon completion of the intervention., Results: Thirty participants in each group completed the study. The mean differences between the baseline and post-test scores in the experimental group for relocation anxiety (t = 5.15, p < .01) and adaptation (t = -5.57, p < .01) were both significant. Among the participants who tested positive for relocation anxiety at pretest (a mean score > 30.13; 83.3% of the participants), those in the experimental group reported a more significant decrease (p < .05) in relocation anxiety at posttest than their control group peers. Among the participants who tested as having poor adaptation pretest (a mean scores < 45.62; 71.7% of the participants), those in the experimental group reported a more significant improvement (p < .05) in adaptation at posttest than their control group peers., Conclusions / Implications for Practice: The results indicate that the 9-week intervention has the potential to help older people with diabetes improve their relocation anxiety and adaptation. This study may be used as a reference to improve emotional distress among residents of long-term care facilities.
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- 2020
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25. [Exploring Sleep Quality, Spiritual Health, and Related Factors in Nurses in the Intensive Care Unit].
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Tsai PC, Lin JH, and Hsu HC
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- Cross-Sectional Studies, Female, Humans, Risk Factors, Surveys and Questionnaires, Taiwan, Intensive Care Units, Nursing Staff, Hospital psychology, Sleep, Spirituality
- Abstract
Background: Nurses in intensive care units (ICUs) care for critically ill and dying patients. The stressful nature of the work performed by these nurses may affect their spiritual health and sleep quality., Purpose: The purpose of this correlational study was to explore the sleep quality, spiritual health, and related factors in a sample of ICU nurses., Methods: A cross-sectional correlational design with stratified random sampling was applied. A total of 170 clinical nurses were recruited from the ICUs of a medical center in northern Taiwan. A demographic characteristics questionnaire, the spiritual health scale-short form, and the Pittsburgh Sleep Quality Index (PSQI) were used for data collection., Results: The average PSQI score was 7.07, with 62.9% of the participants reporting poor sleep quality. A significantly negative correlation was identified between the spiritual-health-scale item "connections to others" and the PSQI. "Connections to others", "chronic diseases", and "menstrual cycle discomfort" were the important predictive factors of sleep quality in the ICU nurses in this study., Conclusions / Implications for Practice: The findings of this study support nurses engaging in regular exercise that is both low-intensity and not subject to time or space restrictions in order to help prevent chronic diseases and relieve dysmenorrhea. Furthermore, education and training related to spiritual health should be incorporated into the whole-person education curriculum in order to enhance spiritual status and improve sleep quality.
- Published
- 2019
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