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3. Oestrogen‐induced angiogenesis promotes adenomyosis by activating the Slug‐VEGF axis in endometrial epithelial cells

Author

Huang, Tze‐Sing, Chen, Yi‐Jen, Chou, Teh‐Ying, Chen, Chih‐Yao, Li, Hsin‐Yang, Huang, Ben‐Shian, Tsai, Hsiao‐Wen, Lan, Hsin‐Yi, Chang, Cheng‐Hsuan, Twu, Nae‐Fang, Yen, Ming‐Shyen, Wang, Peng‐Hui, Chao, Kuan‐Chong, Lee, Chun‐Chung, and Yang, Muh‐Hwa

Subjects
2.1 Biological and endogenous factors, Aetiology, Cardiovascular, Adenomyosis, Animals, Blotting, Western, Cells, Cultured, Endometriosis, Endometrium, Epithelial Cells, Estrogens, Female, Humans, Immunoenzyme Techniques, Mice, Mice, Inbred NOD, Mice, SCID, Myometrium, Neovascularization, Pathologic, Snail Family Transcription Factors, Transcription Factors, Vascular Endothelial Growth Factor A, Slug, adenomyosis, angiogenesis, epithelial-mesenchymal transition, oestrogen, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Clinical Sciences, Biochemistry & Molecular Biology
Abstract

Adenomyosis is an oestrogen-dependent disease characterized by the invasion of endometrial epithelial cells into the myometrium of uterus, and angiogenesis is thought to be required for the implantation of endometrial glandular tissues during the adenomyotic pathogenesis. In this study, we demonstrate that compared with eutopic endometria, adenomyotic lesions exhibited increased vascularity as detected by sonography. Microscopically, the lesions also exhibited an oestrogen-associated elevation of microvascular density and VEGF expression in endometrial epithelial cells. We previously reported that oestrogen-induced Slug expression was critical for endometrial epithelial-mesenchymal transition and development of adenomyosis. Our present studies demonstrated that estradiol (E2) elicited a Slug-VEGF axis in endometrial epithelial cells, and also induced pro-angiogenic activity in vascular endothelial cells. The antagonizing agents against E2 or VEGF suppressed endothelial cells migration and tubal formation. Animal experiments furthermore confirmed that blockage of E2 or VEGF was efficient to attenuate the implantation of adenomyotic lesions. These results highlight the importance of oestrogen-induced angiogenesis in adenomyosis development and provide a potential strategy for treating adenomyosis through intercepting the E2-Slug-VEGF pathway.

Published
2014

4. Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan

Author

Chang, Yen-Hou, Chang, Yi, Chao, Kuan-Chong, Chen, Yi-Jen, Chuang, Chi-Mu, Huang, Chen-Yu, Jiang, Ling-Yu, Li, Hsin-Yang, Liu, Chia-Hao, Sun, Pi-Lin, Wen, Kuo-Chang, Wu, Hua-Hsi, Yu, Hann-Chin, Ju, Fong-Yuan, Tsai, Chih-Ping, Chang, Wen-Hsun, Hsu, Yen-Mei, Huang, Shu-Yun, Lee, Na-Rong, Chen, Chih-Yao, Chang, Ting-Chen, Chang, Wen-Chun, Chen, Chii-Hou, Chen, Ruey-Jian, Chow, Song-Nan, Lien, Yih-Ron, Sheu, Bor-Ching, Torng, Pao-Ling, Yen, Men-Luh, Lee, Wen-Ling, Wang, Kuan-Chin, Chang, Chih-Long, Chen, Chih-Ping, Chen, Jen-Ruei, Chen, Tze-Chien, Huang, Jian-Pei, Huang, Ming-Chao, Wang, Yeou-Lih, Chang, Cheng-Chang, Liu, Jah-Yao, Su, Her-Young, Wang, Yu-Chi, Yu, Mu-Hsien, Chu, Ching-Chuang, Huang, Lee-Wen, Seow, Kok-Min, Lai, Tsung-Hsuan, Lee, Fa-Kung, Chen, Ching-Hui, Liu, Wei-Min, Chiou, Jyh-Shin, Huang, Ben-Shian, Lu, Yen-Feng, Hsiao, Sheng-Mou, Sun, Hsu-Dong, Wu, Wen-Yih, Chen, Kuo-Hu, Hung, Jeng-Hsiu, Lai, Hung-Cheng, Yuan, Chiou-Chung, Hsieh, Ching-Hung, Wang, Chin-Jung, Chan, Chia-Hao, Chang, Shing-Jyh, Shih, Chuan-Chi, Hung, Man-Jung, Hsu, Shih-Tien, Ke, Yu-Min, Lu, Chien-Hsing, Sun, Lou, Chang, Wei-Chun, Hung, Yao-Ching, Lin, Wu-Chou, Wang, Po-Hui, Chen, Tze-Ho, Li, Yiu-Tai, Wu, Meng-Hsing, Huang, Kuo-Feng, Chuang, Fei-Chi, Fu, Hung-Chun, Kung, Fu-Tsai, Huang, Kuan-Hui, Chen, San-Nung, Chiang, An-Jen, Li, Ju-Yueh, Lin, Li-Te, Tsai, Hsiao-Wen, Tsui, Kuan-Hao, Teng, Sen-Wen, Horng, Huann-Cheng, Ho, Chi-Hong, Yen, Ming-Shyen, Chao, Hsiang-Tai, and Wang, Peng-Hui

Published
2016
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6. Uterine sarcoma part III—Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review

Author

Chang, Yen-Hou, Chang, Yi, Chao, Hsiang-Tai, Chao, Kuan-Chong, Chuang, Chi-Mu, Ho, Chi-Hong, Horng, Huann-Cheng, Huang, Chen-Yu, Jiang, Ling-Yu, Liu, Chia-Hao, Li, Hsin-Yang, Sun, Pi-Lin, Wu, Hua-Hsi, Ju, Fong-Yuan, Tsai, Chih-Ping, Chang, Wen-Hsun, Hsu, Yen-Mei, Huang, Shu-Yun, Lee, Na-Rong, Chen, Chih-Yao, Chang, Wen-Chun, Chen, Chii-Hou, Chen, Ruey-Jian, Chow, Song-Nan, Lien, Yih-Ron, Sheu, Bor-Ching, Torng, Pao-Ling, Wei, Lin-Hung, Yen, Men-Luh, Lee, Wen-Ling, Wang, Kuan-Chin, Chang, Chih-Long, Chen, Chih-Ping, Chen, Tze-Chien, Huang, Jian-Pei, Huang, Ming-Chao, Wang, Yeou-Lih, Chang, Cheng-Chang, Liu, Jah-Yao, Su, Her-Young, Wang, Yu-Chi, Yu, Mu-Hsien, Chu, Ching-Chuang, Huang, Lee-Wen, Seow, Kok-Min, Lai, Tsung-Hsuan, Lee, Fa-Kung, Chen, Ching-Hui, Liu, Wei-Min, Chiou, Jyh-Shin, Huang, Ben-Shian, Lu, Yen-Feng, Hsiao, Sheng-Mou, Sun, Hsu-Dong, Wu, Wen-Yih, Teng, Sen-Wen, Chen, Kuo-Hu, Hung, Jeng-Hsiu, Lai, Hung-Cheng, Yuan, Chiou-Chung, Hsieh, Ching-Hung, Wang, Chin-Jung, Chan, Chia-Hao, Chang, Shing-Jyh, Shih, Chuan-Chi, Hung, Man-Jung, Hsu, Shih-Tien, Ke, Yu-Min, Lu, Chien-Hsing, Sun, Lou, Chang, Wei-Chun, Hung, Yao-Ching, Lin, Wu-Chou, Wang, Po-Hui, Chen, Tze-Ho, Wu, Meng-Hsing, Li, Yiu-Tai, Huang, Kuo-Feng, Chuang, Fei-Chi, Fu, Hung-Chun, Kung, Fu-Tsai, Huang, Kuan-Hui, Chen, San-Nung, Chiang, An-Jen, Li, Ju-Yueh, Liou, Wen-Shiung, Lin, Li-Te, Tsai, Hsiao-Wen, Tsui, Kuan-Hao, Yen, Ming-Shyen, Chen, Jen-Ruei, Wang, Peng-Hui, Wen, Kuo-Chang, Chen, Yi-Jen, and Ng, Heung-Tat

Published
2016
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7. Uterine sarcoma Part II—Uterine endometrial stromal sarcoma: The TAG systematic review

Author

Chang, Yen-Hou, Chang, Yi, Chao, Hsiang-Tai, Chao, Kuan-Chong, Chuang, Chi-Mu, Ho, Chi-Hong, Huang, Chen-Yu, Hung, Zhi-Chen, Jiang, Ling-Yu, Lau, Hei-Yu, Li, Hsin-Yang, Lin, Chi-Yao, Liu, Chia-Hao, Sun, Pi-Lin, Twu, Nae-Fang, Wu, Hua-Hsi, Yu, Hann-Chin, Ju, Fong-Yuan, Tsai, Chih-Ping, Chang, Wen-Hsun, Hsu, Yen-Mei, Lee, Na-Rong, Chen, Chih-Yao, Chang, Ting-Chen, Chang, Wen-Chun, Chen, Chii-Hou, Chen, Ruey-Jian, Chow, Song-Nan, Lien, Yih-Ron, Sheu, Bor-Ching, Torng, Pao-Ling, Yen, Men-Luh, Lee, Wen-Ling, Wang, Kuan-Chin, Chang, Chih-Long, Chen, Chih-Ping, Chen, Jen-Ruei, Chen, Tze-Chien, Huang, Jian-Pei, Huang, Ming-Chao, Wang, Yeou-Lih, Chang, Cheng-Chang, Liu, Jah-Yao, Su, Her-Young, Wang, Yu-Chi, Yu, Mu-Hsien, Huang, Lee-Wen, Seow, Kok-Min, Lai, Tsung-Hsuan, Lee, Fa-Kung, Chen, Ching-Hui, Huang, Ben-Shian, Hsiao, Sheng-Mou, Sun, Hsu-Dong, Wu, Wen-Yih, Teng, Sen-Wen, Chen, Kuo-Hu, Hung, Jeng-Hsiu, Lai, Hung-Cheng, Yuan, Chiou-Chung, Hsieh, Ching-Hung, Wang, Chin-Jung, Chang, Shing-Jyh, Hung, Man-Jung, Hsu, Shih-Tien, Ke, Yu-Min, Lu, Chien-Hsing, Sun, Lou, Chang, Wei-Chun, Hung, Yao-Ching, Lin, Wu-Chou, Wang, Po-Hui, Chen, Tze-Ho, Li, Yiu-Tai, Wu, Meng-Hsing, Huang, Kuo-Feng, Fu, Hung-Chun, Chen, San-Nung, Chiang, An-Jen, Li, Ju-Yueh, Lin, Li-Te, Tsai, Hsiao-Wen, Tsui, Kuan-Hao, Horng, Huann-Cheng, Wen, Kuo-Chang, Wang, Peng-Hui, Chen, Yi-Jen, Yen, Ming-Shyen, and Ng, Heung-Tat

Published
2016
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8. Uterine sarcoma Part I—Uterine leiomyosarcoma: The Topic Advisory Group systematic review

Author

Chang, Yen-Hou, Chang, Yi, Chao, Hsiang-Tai, Chao, Kuan-Chong, Chuang, Chi-Mu, Ho, Chi-Hong, Huang, Chen-Yu, Hung, Zhi-Chen, Jiang, Ling-Yu, Lau, Hei-Yu, Li, Hsin-Yang, Lin, Chi-Yao, Liu, Chia-Hao, Sun, Pi-Lin, Twu, Nae-Fang, Wu, Hua-Hsi, Yu, Hann-Chin, Ju, Fong-Yuan, Tsai, Chih-Ping, Chang, Wen-Hsun, Hsu, Yen-Mei, Lee, Na-Rong, Chen, Chih-Yao, Chang, Ting-Chen, Chang, Wen-Chun, Chen, Chii-Hou, Chen, Ruey-Jian, Chow, Song-Nan, Lien, Yih-Ron, Sheu, Bor-Ching, Torng, Pao-Ling, Yen, Men-Luh, Lee, Wen-Ling, Wang, Kuan-Chin, Chang, Chih-Long, Chen, Chih-Ping, Chen, Jen-Ruei, Chen, Tze-Chien, Huang, Jian-Pei, Huang, Ming-Chao, Wang, Yeou-Lih, Chang, Cheng-Chang, Liu, Jah-Yao, Su, Her-Young, Wang, Yu-Chi, Yu, Mu-Hsien, Huang, Lee-Wen, Seow, Kok-Min, Lai, Tsung-Hsuan, Lee, Fa-Kung, Chen, Ching-Hui, Huang, Ben-Shian, Hsiao, Sheng-Mou, Sun, Hsu-Dong, Wu, Wen-Yih, Teng, Sen-Wen, Chen, Kuo-Hu, Hung, Jeng-Hsiu, Lai, Hung-Cheng, Yuan, Chiou-Chung, Hsieh, Ching-Hung, Wang, Chin-Jung, Chang, Shing-Jyh, Hung, Man-Jung, Hsu, Shih-Tien, Ke, Yu-Min, Lu, Chien-Hsing, Sun, Lou, Chang, Wei-Chun, Hung, Yao-Ching, Lin, Wu-Chou, Wang, Po-Hui, Chen, Tze-Ho, Li, Yiu-Tai, Wu, Meng-Hsing, Huang, Kuo-Feng, Fu, Hung-Chun, Chen, San-Nung, Chiang, An-Jen, Li, Ju-Yueh, Lin, Li-Te, Tsai, Hsiao-Wen, Tsui, Kuan-Hao, Wen, Kuo-Chang, Horng, Huann-Cheng, Wang, Peng-Hui, Chen, Yi-Jen, Yen, Ming-Shyen, and Ng, Heung-Tat

Published
2016
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10. Comparison of single-incision mini-slings (Ajust) and standard transobturator midurethral slings (Align) in the management of female stress urinary incontinence: A 1-year follow-up

Author

Chuang, Chi-Mu, Chang, Yen-Hou, Wu, Hua-Hsi, Lau, Hei-Yu, Tseng, Jen-Yu, Tsai, Hsiao-Wen, Twu, Nae-Fong, Chao, Hsiang-Tai, Chang, Chia-Pei, Chang, Wen-Hsun, Hsu, Yen-Mei, Chen, Yi-Jen, Wen, Kuo-Chang, Chao, Kuan-Chong, Yen, Ming-Shyen, Horng, Huann-Cheng, and Wang, Peng-Hui

Published
2015
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15. Influential factors of urinary arsenic levels in the population residing close to one heavy-industrial area in Taiwan - A case study

Author

Kaewlaoyoong, Acharee, primary, Huang, Shih-Ting, additional, Wang, Shu-Li, additional, Sun, Chien-Wen, additional, Chen, Jia-Jen, additional, Kuo, Chao-Hung, additional, Hung, Chih-Hsing, additional, Chen, Szu-Chia, additional, Liang, Ching-Chao, additional, Tsai, Hsiao-Wen, additional, Wu, Chia-Fang, additional, Lin, Wen-Yi, additional, and Wu, Ming-Tsang, additional

Published
2022
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36. High serum anti-Müllerian hormone concentrations have a negative impact on fertilization and embryo development rates.

Author

Tsai, Hsiao-Wen, Liao, Pei-Fen, Li, Chia-Jung, Lin, Li-Te, Wen, Zhi-Hong, and Tsui, Kuan-Hao

Subjects
*ANTI-Mullerian hormone, *EMBRYOS, *ANDROGEN receptors, *REPRODUCTIVE technology, *REGRESSION analysis, *LINEAR statistical models
Abstract

What is the impact of high serum anti-Müllerian hormone (AMH) concentrations on fertilization and embryo development among infertile women undergoing treatment with assisted reproductive technology (ART)? Retrospective study of 1036 infertile women undergoing ART; women were divided into three groups according to serum AMH concentrations: AMH <1.1 ng/ml, 1.1–5.0 ng/ml and >5.0 ng/ml. The fertilization and embryo development rates of patients with different AMH concentrations and after stratification according to age were compared. Women with high AMH concentrations were younger and had higher testosterone concentrations (0.4 ± 0.13 versus 0.3 ± 0.12 versus 0.3 ± 0.08 µg/dl, P < 0.001) than women with low AMH concentrations. However, analysis of the embryo development rate showed negative outcomes for women with high AMH concentrations, including a poor fertilization rate (76.3 ± 17.36 versus 82.1 ± 19.15 versus 82.4 ± 25.38, P = 0.003), and poor day 3 embryo development rate (55.6 ± 23.88 versus 62.6 ± 26.52 versus 62.8 ± 32.65, P = 0.014). Multivariate linear regression analysis showed significantly negative correlations of the AMH concentrations with the fertilization rate (P < 0.001) and day 3 embryo development rate (P = 0.006). Subgroup analysis showed that age 30 years or younger had a significant negative correlation with AMH and the embryo development rate, including the fertilization rate (P < 0.001) and day 3 embryo development rate (P = 0.037). These results suggest that high serum AMH concentrations, contributing to a hyperandrogenic environment and leading to decreased oocyte developmental competence, may have a negative impact on fertilization and the early stage of embryo development in women undergoing treatment with ART. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Long-term compliance of vaginal pessaries

Author

Hsieh, Ming-Fang, Tsai, Hsiao-Wen, Liou, Wen-Shiung, Lo, Ching-Chuan, Lin, Zi-Han, An, Ya-Fen, and Lin, Hsin-Yin

Subjects
Time Factors, Urinary Incontinence, Stress, Observational Study, Middle Aged, Pessaries, pelvic organ prolapse, compliance, stress urinary incontinence, Severity of Illness Index, Age Distribution, Humans, Patient Compliance, Female, vaginal pessary, Research Article, Aged, Proportional Hazards Models, Retrospective Studies
Abstract

Vaginal pessary treatment for pelvic organ prolapse (POP) is relatively safe and cost-effective. Since long-term use is an important key to keep the benefit of pessary treatment, we would like to investigate the factors which might affect the compliance of vaginal pessaries. In this retrospective study, 65 women were included, and we found poor compliance in women with severe stress urinary incontinence (SUI) after reduction (1-hour pad test >10 gm vs ≦10 gm, 57.1% vs. 84.3%, P = .027). Besides, women younger than 60 years-old also had poor compliance (age ≦60-year-old vs >60-year-old, 58.3% vs 83.0%, P = .04). Other factors such as POP stage, history of hysterectomy, and types of pessaries, did not show significant influence on the long-term compliance in this study. Therefore, to evaluate the severity of SUI after reduction before providing pessary treatment is important to predict long-term compliance. Meanwhile, long-term pessary treatment seems to be more acceptable to elderly patients.

Published
2019

38. Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: A retrospective cohort study 11 Medical and Health Sciences 1114 Paediatrics and Reproductive Medicine

Author

Chern, Chyi-Uei, Tsui, Kuan-Hao, Vitale, Salvatore Giovanni, Chen, San-Nung, Wang, Peng-Hui, Cianci, Antonio, Tsai, Hsiao-Wen, Wen, Zhi-Hong, and Lin, Li-Te

Subjects
Adult, Pregnancy Rate, Oocyte Retrieval, Obstetrics and Gynecology, Dehydroepiandrosterone, Fertilization in Vitro, Diminished ovarian reserve, Logistic Models, Endocrinology, Reproductive Medicine, Pregnancy, In vitro fertilization, Poor ovarian responders, Multivariate Analysis, DHEA, Female, Humans, Retrospective Studies, Developmental Biology
Published
2018

46. Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan

Author

Teng, Sen-Wen, primary, Horng, Huann-Cheng, additional, Ho, Chi-Hong, additional, Yen, Ming-Shyen, additional, Chao, Hsiang-Tai, additional, Wang, Peng-Hui, additional, Chang, Yen-Hou, additional, Chang, Yi, additional, Chao, Kuan-Chong, additional, Chen, Yi-Jen, additional, Chuang, Chi-Mu, additional, Huang, Chen-Yu, additional, Jiang, Ling-Yu, additional, Li, Hsin-Yang, additional, Liu, Chia-Hao, additional, Sun, Pi-Lin, additional, Wen, Kuo-Chang, additional, Wu, Hua-Hsi, additional, Yu, Hann-Chin, additional, Ju, Fong-Yuan, additional, Tsai, Chih-Ping, additional, Chang, Wen-Hsun, additional, Hsu, Yen-Mei, additional, Huang, Shu-Yun, additional, Lee, Na-Rong, additional, Chen, Chih-Yao, additional, Chang, Ting-Chen, additional, Chang, Wen-Chun, additional, Chen, Chii-Hou, additional, Chen, Ruey-Jian, additional, Chow, Song-Nan, additional, Lien, Yih-Ron, additional, Sheu, Bor-Ching, additional, Torng, Pao-Ling, additional, Yen, Men-Luh, additional, Lee, Wen-Ling, additional, Wang, Kuan-Chin, additional, Chang, Chih-Long, additional, Chen, Chih-Ping, additional, Chen, Jen-Ruei, additional, Chen, Tze-Chien, additional, Huang, Jian-Pei, additional, Huang, Ming-Chao, additional, Wang, Yeou-Lih, additional, Chang, Cheng-Chang, additional, Liu, Jah-Yao, additional, Su, Her-Young, additional, Wang, Yu-Chi, additional, Yu, Mu-Hsien, additional, Chu, Ching-Chuang, additional, Huang, Lee-Wen, additional, Seow, Kok-Min, additional, Lai, Tsung-Hsuan, additional, Lee, Fa-Kung, additional, Chen, Ching-Hui, additional, Liu, Wei-Min, additional, Chiou, Jyh-Shin, additional, Huang, Ben-Shian, additional, Lu, Yen-Feng, additional, Hsiao, Sheng-Mou, additional, Sun, Hsu-Dong, additional, Wu, Wen-Yih, additional, Chen, Kuo-Hu, additional, Hung, Jeng-Hsiu, additional, Lai, Hung-Cheng, additional, Yuan, Chiou-Chung, additional, Hsieh, Ching-Hung, additional, Wang, Chin-Jung, additional, Chan, Chia-Hao, additional, Chang, Shing-Jyh, additional, Shih, Chuan-Chi, additional, Hung, Man-Jung, additional, Hsu, Shih-Tien, additional, Ke, Yu-Min, additional, Lu, Chien-Hsing, additional, Sun, Lou, additional, Chang, Wei-Chun, additional, Hung, Yao-Ching, additional, Lin, Wu-Chou, additional, Wang, Po-Hui, additional, Chen, Tze-Ho, additional, Li, Yiu-Tai, additional, Wu, Meng-Hsing, additional, Huang, Kuo-Feng, additional, Chuang, Fei-Chi, additional, Fu, Hung-Chun, additional, Kung, Fu-Tsai, additional, Huang, Kuan-Hui, additional, Chen, San-Nung, additional, Chiang, An-Jen, additional, Li, Ju-Yueh, additional, Lin, Li-Te, additional, Tsai, Hsiao-Wen, additional, and Tsui, Kuan-Hao, additional

Published
2016
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47. Oestrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells

Author

Huang, Tze-Sing, Chen, Yi-Jen, Chou, Teh-Ying, Chen, Chih-Yao, Li, Hsin-Yang, Huang, Ben-Shian, Tsai, Hsiao-Wen, Lan, Hsin-Yi, Chang, Cheng-Hsuan, Twu, Nae-Fang, Yen, Ming-Shyen, Wang, Peng-Hui, Chao, Kuan-Chong, Lee, Chun-Chung, and Yang, Muh-Hwa

Subjects
Vascular Endothelial Growth Factor A, Biochemistry & Molecular Biology, Cells, Clinical Sciences, Endometriosis, epithelial-mesenchymal transition, SCID, Immunoenzyme Techniques, Endometrium, Mice, angiogenesis, Medicinal and Biomolecular Chemistry, Animals, Humans, Neovascularization, Pathologic, Cultured, Blotting, Epithelial Cells, Estrogens, Slug, adenomyosis, Myometrium, Inbred NOD, Female, Snail Family Transcription Factors, Biochemistry and Cell Biology, oestrogen, Western, Adenomyosis, Transcription Factors
Abstract

Adenomyosis is an oestrogen-dependent disease characterized by the invasion of endometrial epithelial cells into the myometrium of uterus, and angiogenesis is thought to be required for the implantation of endometrial glandular tissues during the adenomyotic pathogenesis. In this study, we demonstrate that compared with eutopic endometria, adenomyotic lesions exhibited increased vascularity as detected by sonography. Microscopically, the lesions also exhibited an oestrogen-associated elevation of microvascular density and VEGF expression in endometrial epithelial cells. We previously reported that oestrogen-induced Slug expression was critical for endometrial epithelial-mesenchymal transition and development of adenomyosis. Our present studies demonstrated that estradiol (E2) elicited a Slug-VEGF axis in endometrial epithelial cells, and also induced pro-angiogenic activity in vascular endothelial cells. The antagonizing agents against E2 or VEGF suppressed endothelial cells migration and tubal formation. Animal experiments furthermore confirmed that blockage of E2 or VEGF was efficient to attenuate the implantation of adenomyotic lesions. These results highlight the importance of oestrogen-induced angiogenesis in adenomyosis development and provide a potential strategy for treating adenomyosis through intercepting the E2-Slug-VEGF pathway.

Published
2014

49. Uterine sarcoma part III—Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review

Author

Yen, Ming-Shyen, primary, Chen, Jen-Ruei, additional, Wang, Peng-Hui, additional, Wen, Kuo-Chang, additional, Chen, Yi-Jen, additional, Ng, Heung-Tat, additional, Chang, Yen-Hou, additional, Chang, Yi, additional, Chao, Hsiang-Tai, additional, Chao, Kuan-Chong, additional, Chuang, Chi-Mu, additional, Ho, Chi-Hong, additional, Horng, Huann-Cheng, additional, Huang, Chen-Yu, additional, Jiang, Ling-Yu, additional, Liu, Chia-Hao, additional, Li, Hsin-Yang, additional, Sun, Pi-Lin, additional, Wu, Hua-Hsi, additional, Ju, Fong-Yuan, additional, Tsai, Chih-Ping, additional, Chang, Wen-Hsun, additional, Hsu, Yen-Mei, additional, Huang, Shu-Yun, additional, Lee, Na-Rong, additional, Chen, Chih-Yao, additional, Chang, Wen-Chun, additional, Chen, Chii-Hou, additional, Chen, Ruey-Jian, additional, Chow, Song-Nan, additional, Lien, Yih-Ron, additional, Sheu, Bor-Ching, additional, Torng, Pao-Ling, additional, Wei, Lin-Hung, additional, Yen, Men-Luh, additional, Lee, Wen-Ling, additional, Wang, Kuan-Chin, additional, Chang, Chih-Long, additional, Chen, Chih-Ping, additional, Chen, Tze-Chien, additional, Huang, Jian-Pei, additional, Huang, Ming-Chao, additional, Wang, Yeou-Lih, additional, Chang, Cheng-Chang, additional, Liu, Jah-Yao, additional, Su, Her-Young, additional, Wang, Yu-Chi, additional, Yu, Mu-Hsien, additional, Chu, Ching-Chuang, additional, Huang, Lee-Wen, additional, Seow, Kok-Min, additional, Lai, Tsung-Hsuan, additional, Lee, Fa-Kung, additional, Chen, Ching-Hui, additional, Liu, Wei-Min, additional, Chiou, Jyh-Shin, additional, Huang, Ben-Shian, additional, Lu, Yen-Feng, additional, Hsiao, Sheng-Mou, additional, Sun, Hsu-Dong, additional, Wu, Wen-Yih, additional, Teng, Sen-Wen, additional, Chen, Kuo-Hu, additional, Hung, Jeng-Hsiu, additional, Lai, Hung-Cheng, additional, Yuan, Chiou-Chung, additional, Hsieh, Ching-Hung, additional, Wang, Chin-Jung, additional, Chan, Chia-Hao, additional, Chang, Shing-Jyh, additional, Shih, Chuan-Chi, additional, Hung, Man-Jung, additional, Hsu, Shih-Tien, additional, Ke, Yu-Min, additional, Lu, Chien-Hsing, additional, Sun, Lou, additional, Chang, Wei-Chun, additional, Hung, Yao-Ching, additional, Lin, Wu-Chou, additional, Wang, Po-Hui, additional, Chen, Tze-Ho, additional, Wu, Meng-Hsing, additional, Li, Yiu-Tai, additional, Huang, Kuo-Feng, additional, Chuang, Fei-Chi, additional, Fu, Hung-Chun, additional, Kung, Fu-Tsai, additional, Huang, Kuan-Hui, additional, Chen, San-Nung, additional, Chiang, An-Jen, additional, Li, Ju-Yueh, additional, Liou, Wen-Shiung, additional, Lin, Li-Te, additional, Tsai, Hsiao-Wen, additional, and Tsui, Kuan-Hao, additional

Published
2016
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50. Uterine sarcoma Part I—Uterine leiomyosarcoma: The Topic Advisory Group systematic review

Author

Wen, Kuo-Chang, primary, Horng, Huann-Cheng, additional, Wang, Peng-Hui, additional, Chen, Yi-Jen, additional, Yen, Ming-Shyen, additional, Ng, Heung-Tat, additional, Chang, Yen-Hou, additional, Chang, Yi, additional, Chao, Hsiang-Tai, additional, Chao, Kuan-Chong, additional, Chuang, Chi-Mu, additional, Ho, Chi-Hong, additional, Huang, Chen-Yu, additional, Hung, Zhi-Chen, additional, Jiang, Ling-Yu, additional, Lau, Hei-Yu, additional, Li, Hsin-Yang, additional, Lin, Chi-Yao, additional, Liu, Chia-Hao, additional, Sun, Pi-Lin, additional, Twu, Nae-Fang, additional, Wu, Hua-Hsi, additional, Yu, Hann-Chin, additional, Ju, Fong-Yuan, additional, Tsai, Chih-Ping, additional, Chang, Wen-Hsun, additional, Hsu, Yen-Mei, additional, Lee, Na-Rong, additional, Chen, Chih-Yao, additional, Chang, Ting-Chen, additional, Chang, Wen-Chun, additional, Chen, Chii-Hou, additional, Chen, Ruey-Jian, additional, Chow, Song-Nan, additional, Lien, Yih-Ron, additional, Sheu, Bor-Ching, additional, Torng, Pao-Ling, additional, Yen, Men-Luh, additional, Lee, Wen-Ling, additional, Wang, Kuan-Chin, additional, Chang, Chih-Long, additional, Chen, Chih-Ping, additional, Chen, Jen-Ruei, additional, Chen, Tze-Chien, additional, Huang, Jian-Pei, additional, Huang, Ming-Chao, additional, Wang, Yeou-Lih, additional, Chang, Cheng-Chang, additional, Liu, Jah-Yao, additional, Su, Her-Young, additional, Wang, Yu-Chi, additional, Yu, Mu-Hsien, additional, Huang, Lee-Wen, additional, Seow, Kok-Min, additional, Lai, Tsung-Hsuan, additional, Lee, Fa-Kung, additional, Chen, Ching-Hui, additional, Huang, Ben-Shian, additional, Hsiao, Sheng-Mou, additional, Sun, Hsu-Dong, additional, Wu, Wen-Yih, additional, Teng, Sen-Wen, additional, Chen, Kuo-Hu, additional, Hung, Jeng-Hsiu, additional, Lai, Hung-Cheng, additional, Yuan, Chiou-Chung, additional, Hsieh, Ching-Hung, additional, Wang, Chin-Jung, additional, Chang, Shing-Jyh, additional, Hung, Man-Jung, additional, Hsu, Shih-Tien, additional, Ke, Yu-Min, additional, Lu, Chien-Hsing, additional, Sun, Lou, additional, Chang, Wei-Chun, additional, Hung, Yao-Ching, additional, Lin, Wu-Chou, additional, Wang, Po-Hui, additional, Chen, Tze-Ho, additional, Li, Yiu-Tai, additional, Wu, Meng-Hsing, additional, Huang, Kuo-Feng, additional, Fu, Hung-Chun, additional, Chen, San-Nung, additional, Chiang, An-Jen, additional, Li, Ju-Yueh, additional, Lin, Li-Te, additional, Tsai, Hsiao-Wen, additional, and Tsui, Kuan-Hao, additional

Published
2016
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