1. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis
- Author
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Rooij, F.J.A. (Frank) van, Qayyum, Q. (Rehan), Smith, A.V. (Albert Vernon), Zhou, Y. (Yi), Trompet, S. (Stella), Tanaka, T. (Toshiko), Keller, M.F. (Margaux), Chang, L.-C. (Li-Ching), Schmidt, H. (Helena), Yang, M.-L. (Min-Lee), Chen, M.-H. (Ming-Huei), Hayes, J. (James), Johnson, A.D. (Andrew), Yanek, L.R. (Lisa), Mueller, C. (Christian), Lange, L.A. (Leslie), Floyd, J. (James), Ghanbari, M. (Mohsen), Zonderman, A.B., Jukema, J.W., Hofman, A. (Albert), Duijn, C.M. (Cornelia) van, Desch, K.C. (Karl C.), Saba, Y. (Yasaman), Ozel, A.B. (Ayse), Snively, B.M. (Beverly M.), Wu, J.-Y. (Jer-Yuarn), Schmidt, R. (Reinhold), Fornage, M. (Myriam), Klein, R.J. (Robert J.), Fox, C.S. (Caroline), Matsuda, K. (Koichi), Kamatani, N. (Naoyuki), Wild, P.S. (Philipp S.), Stott, D.J. (David J.), Ford, I., Slagboom, P.E. (Eline), Yang, J. (Jaden), Chu, A.Y. (Audrey Y), Lambert, A.J. (Amy J.), Uitterlinden, A.G. (André), Franco, O.H. (Oscar), Hofer, E. (Edith), Ginsburg, D. (David), Hu, B. (Bella), Keating, J. (John), Schick, U.M. (Ursula), Brody, J.A. (Jennifer A.), Li, J.Z. (Jun Z.), Chen, Z. (Zhao), Zeller, T. (Tanja), Guralnik, J.M. (Jack M.), Chasman, D.I. (Daniel), Peters, L.L. (Luanne L.), Kubo, M. (Michiaki), Becker, D.M. (Diane M.), Li, J. (Jin), Eiriksdottir, G. (Gudny), Rotter, J.I. (Jerome I.), Levy, D. (Daniel), Grossmann, V. (Vera), Patel, K.V. (Kushang V.), Chen, C.-H., Ridker, P.M. (Paul M.), Tang, H. (Hua), Launer, L.J. (Lenore), Rice, K.M. (Kenneth M.), Li-Gao, R. (Ruifang), Ferrucci, L. (Luigi), Evans, M.K. (Michelle K.), Choudhuri, A. (Avik), Trompouki, E. (Eirini), Abraham, B.J. (Brian J.), Yang, S. (Song), Takahashi, A. (Atsushi), Kamatani, Y. (Yoichiro), Kooperberg, C. (Charles), Harris, T.B. (Tamara), Jee, S.H. (Sun Ha), Coresh, J. (Josef), Tsai, F.-J. (Fuu-Jen), Longo, D.L. (Dan L.), Chen, Y.-T. (Yuan-Tsong), Felix, J.F. (Janine), Yang, Q. (Qiong), Psaty, B.M. (Bruce), Boerwinkle, E.A. (Eric), Becker, L.C. (Lewis C.), Mook-Kanamori, D.O. (Dennis), Wilson, J.F. (James), Gudnason, V. (Vilmundur), O'Donnell, C.J. (Christopher J.), Dehghan, A. (Abbas), Cupples, L.A. (Adrienne), Nalls, M.A. (Michael), Morris, A.P. (Andrew), Okada, Y. (Yukinori), Reiner, A.P. (Alexander P.), Zon, L.I. (Leonard), Ganesh, S.K. (Santhi), Rooij, F.J.A. (Frank) van, Qayyum, Q. (Rehan), Smith, A.V. (Albert Vernon), Zhou, Y. (Yi), Trompet, S. (Stella), Tanaka, T. (Toshiko), Keller, M.F. (Margaux), Chang, L.-C. (Li-Ching), Schmidt, H. (Helena), Yang, M.-L. (Min-Lee), Chen, M.-H. (Ming-Huei), Hayes, J. (James), Johnson, A.D. (Andrew), Yanek, L.R. (Lisa), Mueller, C. (Christian), Lange, L.A. (Leslie), Floyd, J. (James), Ghanbari, M. (Mohsen), Zonderman, A.B., Jukema, J.W., Hofman, A. (Albert), Duijn, C.M. (Cornelia) van, Desch, K.C. (Karl C.), Saba, Y. (Yasaman), Ozel, A.B. (Ayse), Snively, B.M. (Beverly M.), Wu, J.-Y. (Jer-Yuarn), Schmidt, R. (Reinhold), Fornage, M. (Myriam), Klein, R.J. (Robert J.), Fox, C.S. (Caroline), Matsuda, K. (Koichi), Kamatani, N. (Naoyuki), Wild, P.S. (Philipp S.), Stott, D.J. (David J.), Ford, I., Slagboom, P.E. (Eline), Yang, J. (Jaden), Chu, A.Y. (Audrey Y), Lambert, A.J. (Amy J.), Uitterlinden, A.G. (André), Franco, O.H. (Oscar), Hofer, E. (Edith), Ginsburg, D. (David), Hu, B. (Bella), Keating, J. (John), Schick, U.M. (Ursula), Brody, J.A. (Jennifer A.), Li, J.Z. (Jun Z.), Chen, Z. (Zhao), Zeller, T. (Tanja), Guralnik, J.M. (Jack M.), Chasman, D.I. (Daniel), Peters, L.L. (Luanne L.), Kubo, M. (Michiaki), Becker, D.M. (Diane M.), Li, J. (Jin), Eiriksdottir, G. (Gudny), Rotter, J.I. (Jerome I.), Levy, D. (Daniel), Grossmann, V. (Vera), Patel, K.V. (Kushang V.), Chen, C.-H., Ridker, P.M. (Paul M.), Tang, H. (Hua), Launer, L.J. (Lenore), Rice, K.M. (Kenneth M.), Li-Gao, R. (Ruifang), Ferrucci, L. (Luigi), Evans, M.K. (Michelle K.), Choudhuri, A. (Avik), Trompouki, E. (Eirini), Abraham, B.J. (Brian J.), Yang, S. (Song), Takahashi, A. (Atsushi), Kamatani, Y. (Yoichiro), Kooperberg, C. (Charles), Harris, T.B. (Tamara), Jee, S.H. (Sun Ha), Coresh, J. (Josef), Tsai, F.-J. (Fuu-Jen), Longo, D.L. (Dan L.), Chen, Y.-T. (Yuan-Tsong), Felix, J.F. (Janine), Yang, Q. (Qiong), Psaty, B.M. (Bruce), Boerwinkle, E.A. (Eric), Becker, L.C. (Lewis C.), Mook-Kanamori, D.O. (Dennis), Wilson, J.F. (James), Gudnason, V. (Vilmundur), O'Donnell, C.J. (Christopher J.), Dehghan, A. (Abbas), Cupples, L.A. (Adrienne), Nalls, M.A. (Michael), Morris, A.P. (Andrew), Okada, Y. (Yukinori), Reiner, A.P. (Alexander P.), Zon, L.I. (Leonard), and Ganesh, S.K. (Santhi)
- Abstract
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPM
- Published
- 2017
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