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In this study, a finite element method proposed by Hsu et al. in 2003 is extended to develop a numerical model for the simulation of wave transformation in the surf zone. The governing equation is the elliptic mild-slope equation including the energy dissipation of wave breaking. At the open boundaries with varying depth, the reflected waves caused by shoaling are adopted to the radiation boundary conditions. The rationality of the present numerical model is examined through the cases of offshore parallel breakwater problems. The results of calculation are in good agreement with experimental results. CE Database subject headings: Finite element method; Wave propagation; Energy dissipation; Boundaries: Surf zone Numerical models.

Background: Maternal nicotine exposure during gestation and lactation adversely affect lung development of their children. High‐mobility group box 1 (HMGB1) is the encoded non‐histone, nuclear DNA‐binding protein that regulates transcription, and is involved in organization of DNA. Receptors for advanced glycation end products (RAGE) is a receptor for HMGB1 and activates nuclear factor‐κB (NF‐κB) signaling. Animal and human studies have found cigarette smoke exposure upregulates RAGE expression, suggesting that the HMGB1‐RAGE pathway might be involved in maternal nicotine‐induced lung injury. Methods: This study evaluated prenatal and perinatal nicotine effects on lung development and HMGB1 and RAGE expression in mouse offspring. Nicotine was administered to pregnant mice by subcutaneous osmotic mini‐pump at a dose of 6 mg kg−1 day−1 from gestational Day 14 to birth (prenatal) or to postnatal Day 21 (perinatal). A control group received an equal volume of saline by the same route. Three study groups were obtained: prenatal normal saline (NS), prenatal nicotine, and perinatal nicotine groups. The mice were euthanized on postnatal Day 21, and the lung tissues were collected for histological and Western blot analyses. Results: Mice exposed to prenatal nicotine exhibited significantly higher lung mean chord length and oxidative stress marker 8‐hydroxy‐2′‐deoxyguanosine and NF‐κB expression compared to mice exposed to NS. Perinatal nicotine exposure further enhanced these harmful effects. These perinatal nicotine effects on lung development were associated with increased HMGB1 and RAGE expression. Conclusions: HMGB1‐RAGE pathway may be involved in the pathogenesis of altered lung development induced by perinatal nicotine exposure. [ABSTRACT FROM AUTHOR]

The aims of this study were to evaluate the probiotic efficiency of Bacillus subtilis E20 (109 colony‐forming units kg−1) on the growth and apparent digestibility coefficients (ADCs) of dry matter (DM), crude protein (CP), amino acids (AAs), and crude lipids (CLs) of the white shrimp, Litopenaeus vannamei. A control diet without probiotic supplementation was used. Shrimp exhibited significant increases in growth performance and feed utilization after being fed the test diet for 56 days. Shrimp were then used to evaluate the apparent nutrient digestibility using 0.1% Cr2O3 in the diet as an indicator. During the trial, faeces was collected from triplicate groups of shrimp twice daily. ADCs of CP and DM in the test diet significantly increased compared to those of the control diet. Although the ADCs of CLs did not significantly differ between the control and probiotic group, the ADC of CLs was higher in the probiotic group than in the control group. In addition, ADCs of most AAs in the test diet were significantly higher compared to those of the control diet. These results suggest that shrimp in the test group had significantly better growth performance, which was due to increases in nutrient digestibility and absorption. [ABSTRACT FROM AUTHOR]

Objective: To describe psychotropic medications prescription patterns among adolescents in Taiwan; focusing on age, gender, duration of treatments and various classes of psychotropic medications.Design: A retrospective description analysis.Setting: Taiwan National Health Insurance Database.Participants: Twelve to seventeen years' patients treated with psychotropic medications.Intervention: None.Main Outcome Measure(s): Percentage and duration of treatment with psychotropic medications during the study periods by medication classes and age groups were calculated. In addition, top three prescribed psychotropic medications were also determined.Results: A total of 3,120 patients were prescribed psychotropic drugs. The percentage of adolescent patients that received anxiolytics and antidepressants in 2002-2012 were 2.89% and 2.15%, respectively. Also, 851 patients (1.21%) were prescribed hypnotics and 638 (0.91%) were given sedatives. The prevalence rate of the prescription of psychotropic drugs increased steadily with age and females were more treated than males except antipsychotic. Among psychotropic drugs, antidepressants (mean: 8.6 times) were refilled more but antipsychotics (mean 188 days) were the long-term treatment drugs. Additionally, the trend of hospital visits fluctuated over the year while May and December showed a higher rate of visits.Conclusions: These findings show that the prevalence of psychotropic drug prescriptions in Taiwanese adolescents is even low but increasing trends in the prescription of these medications raises some concern. As the evidence of psychotropic drug safety and effectiveness in adolescents is still inadequate; we recommend that healthcare providers should consider psychotropic drugs therapy, continuously monitor for outcomes and empower their patients to improve their knowledge, therapeutic outcomes and quality of life. [ABSTRACT FROM AUTHOR]

Evoked neural activity (ensemble single-unit activity and evoked field potential) and functional magnetic resonance imaging (fMRI) changes of the primary somatosensory cortex in response to electrical stimulation of the hind paw were studied in rats under anesthesia. The effects of stimulation frequency (ranging from 0.3 to 10 Hz) and types of anesthetics (alpha-chloralose and sodium pentobarbital) on blood oxygen level dependent (BOLD) activation and neural activation were compared. Both ensemble single-unit activity and BOLD signal changes achieved maximal activation at 3 Hz of stimulation and responses were significantly stronger under alpha-chloralose anesthesia. The maximal activation of the integral evoked potential (sigmaEP), in contrast, was the highest at 10 Hz; and the values were similar for alpha-chloralose and pentobarbital. These analyses revealed that fMRI image changes were better correlated with ensemble single-unit activity than with sigmaEP during somatosensory stimulations.