31 results on '"Trzupek, John D."'
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2. Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives
3. Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist
4. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
5. Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan
6. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization
7. Total synthesis of chloropeptin II (complestatin) and chloropeptin I
8. Toward homogeneous erythropoietin: chemical synthesis of the [Ala.sup.sup.1]-[Gly.sup.28] glycopeptide domain by 'alanine' ligation
9. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation
10. Systematic exploration of the structural features of yatekemycin impacting DNA alkylation and biological activity
11. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
12. Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
13. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
14. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit
15. ChemInform Abstract: Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams.
16. Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams
17. Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
18. ChemInform Abstract: Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet-Spengler Reaction: Traceless Transfer of Chirality from L-Tryptophan.
19. Lessons from the total synthesis of (±)-phalarine: Insights into the mechanism of the Pictet–Spengler reaction
20. Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet−Spengler Reaction: Traceless Transfer of Chirality from l-Tryptophan
21. Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1−Gly28 Glycopeptide Domain by “Alanine” Ligation
22. A Unique Class of Duocarmycin and CC-1065 Analogues Subject to Reductive Activation
23. Asymmetric Total Synthesis of (+)- and ent-(-)-Yatakemycin (I) and Duocarmycin SA (II): Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer.
24. Asymmetric Total Synthesis of (+)- and ent-(−)-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer
25. Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin
26. Photochemical Generation of Ribose Abasic Sites in RNA Oligonucleotides
27. Identification of a ChemicalProbe for Bromo and ExtraC-Terminal Bromodomain Inhibition through Optimization of aFragment-Derived Hit.
28. Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1 —Gly28 Glycopeptide Domain by "Alanine" Ligation.
29. Asymmetric Total Synthesis of (+)- and ent-()-Yatakemycin and Duocarmycin SA: Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer.
30. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
31. A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
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