1. Pediatric Expression of Mast Cell Activation Disorders
- Author
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Lone Agertoft, Michael Boe Møller, Sigurd Broesby-Olsen, Melody C. Carter, Charlotte G. Mortz, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, and Thomas Kielsgaard Kristensen
- Subjects
0301 basic medicine ,Adult ,Urticaria ,Cell Degranulation ,Tryptases/metabolism ,Immunology ,Tryptase ,Proto-Oncogene Proteins c-kit/genetics ,Pathogenesis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Food allergy ,Immunology and Allergy ,Medicine ,Humans ,Mast Cells ,Child ,Anaphylaxis ,biology ,Urticaria pigmentosa ,business.industry ,Mast cell activation ,Mastocytosis/genetics ,KIT mutations ,Anaphylaxis/genetics ,medicine.disease ,Mast cell ,Proto-Oncogene Proteins c-kit ,030104 developmental biology ,medicine.anatomical_structure ,Mast Cells/physiology ,biology.protein ,Tryptases ,business ,Mastocytosis ,Mast cell activation disorders ,Urticaria/genetics - Abstract
Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.
- Published
- 2018
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