1. Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model
- Author
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Xuan-Hai Do, Trong Nghia Nguyen, Thanh Chung Dang, Thi Thanh Mai Nguyen, Trung Nhan Nguyen, Van Nhat Truong Do, Huu Tho Le, Xuan Hai Nguyen, Hoang Phu Dang, Giang-Linh Nguyen, Dinh-Khanh Hoang, Van-Quan Le, and Van-Mao Can
- Subjects
solanum procumbens ,arthritis ,anti-inflammation ,complete freund's adjuvant ,rats ,Arctic medicine. Tropical medicine ,RC955-962 ,Biology (General) ,QH301-705.5 - Abstract
Objective: To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund's adjuvant-induced arthritis rat models. Methods: We isolated and identified five compounds in the ethanol-soluble Solanum procumbens extract (SP) with anti-inflammatory effects, including ursolic acid, β-sitosterol, hexadecanoic acid, cis-vaccenic acid, and vanillic acid. Additionally, we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms, including paw volumes, local temperatures, withdrawal latency, and mechanical withdrawal threshold at the hind paw and white blood cell (WBC) number from complete Freund's adjuvant-induced arthritis rat models. Results: We have successfully established a complete Freund's adjuvant-induced arthritis rat model at a low dose (1 mg/mL). SP extract significantly reduced paw volumes (P
- Published
- 2023
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