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15 results on '"Trotta, M.P."'

2. Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens

Author

Trotta, M.P., Ammassari, A., Cozzi Lepri, A., Zaccarelli, M., Minardi, L., Narciso, P., Melzi, S., Murri, R., Baldelli, F., Noto, P., Vecchiet, J., De Luca, A., d’Arminio Monforte, A., Antinori for the AdICONA, A., and AdeSpall Study Group

Subjects
Adult, Male, Drug, Efavirenz, Settore MED/17 - Malattie Infettive, Substance-Related Disorders, Vomiting, medicine.medical_treatment, media_common.quotation_subject, Immunology, HIV Infections, Pharmacology, Nucleoside Reverse Transcriptase Inhibitor, Cohort Studies, chemistry.chemical_compound, Risk Factors, Antiretroviral Therapy, Highly Active, Surveys and Questionnaires, Humans, Immunology and Allergy, Medicine, Protease inhibitor (pharmacology), Fatigue, media_common, Chemotherapy, Reverse-transcriptase inhibitor, business.industry, virus diseases, HIV Protease Inhibitors, Middle Aged, HIV Reverse Transcriptase, Sexual Dysfunction, Physiological, Regimen, Logistic Models, Infectious Diseases, chemistry, Patient Compliance, Regression Analysis, Female, business, Viral load, medicine.drug
Abstract

The difference between adherence to non- nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI)-based regimens was investigated. Better adherence was found in NNRTI-treated patients, especially when efavirenz was included in the regimen, compared with single PI-treated patients and in those with CD4 cell counts less than 200 x 10(6)/l. By contrast, younger age, self-report of active drug use, fatigue or vomiting negatively affected adherence. Self-reported sexual dysfunction was significantly associated with non-adherence only in PI-treated individuals.

Published
2003
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3. Maraviroc intensification for HIV-1-positive immunological non-responders (INRs) despite virological suppression during HAART

Author

Rusconi, S., Vitiello, P., Adorni, F., Colella, E., Focà, E., Capetti, A.F., Meraviglia, P., Abeli, C., Bonora, S., D' Annunzio, M., Di Biagio, A., Di Pietro, A., Butini, L., Orofino, G., Farina, S., D' Ettorre, G., Francisci, D., Soria, A., Buonomini, A.R., Tommasi, C., Trotta, M.P., Capasso, M., Merlini, E., and Marchetti, G.C.

Subjects
Maraviroc -- Dosage and administration -- Testing, Highly active antiretroviral therapy -- Dosage and administration -- Patient outcomes, HIV infection -- Drug therapy -- Development and progression, Health
Abstract

7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK, Purpose 15‐30% of HAART‐treated HIV‐1‐positive patients (pts) lack CD4+ increase despite full HIV viremia suppression. The increased risk for INR to progress till AIDS led us to investigate maraviroc (MVC) [...]

Published
2010
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6. Patient-reported and physician estimated adherence to HAART : social and clinic center related factors are associated with discordance

Author

Murri, R., Ammassari, A., Trotta, M.P., De Luca, A., Melzi, S., Minardi, C., Zaccarelli, M., Rellecati, P., Santopadre, P., Soscia, F., Scasso, A., Tozzi, V., Ciardi, M., Orofino, G.C., Noto, P., d'Arminio Monforte, A., Antinori, A., A. W., W., and AdICoNA Study Group

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, AIDS/HIV, Compliance, Doctor-patient relationship, Health care service, Quality of care, Psychological intervention, Sensitivity and Specificity, Acquired immunodeficiency syndrome (AIDS), Antiretroviral Therapy, Highly Active, Internal Medicine, Humans, Medicine, Prospective Studies, Risk factor, Sida, Prospective cohort study, Aged, Academic Medical Centers, biology, business.industry, Original Articles, Middle Aged, biology.organism_classification, medicine.disease, Socioeconomic Factors, Cohort, Educational Status, Patient Compliance, Doctor–patient relationship, Female, Factor Analysis, Statistical, business, Cohort study
Abstract

OBJECTIVES: To evaluate the rate of discordance between patients and physicians on adherence to highly active antiretroviral therapy (HAART) and identify factors related to discordance in these two assessments. DESIGN: Prospective, multicenter, cohort study (AdICONA) nested within the Italian Cohort Naive Antiretrovirals (ICONA) study. SETTING: Tertiary clinical centers. PARTICIPANTS: The patients filled out a 16-item self-administered questionnaire on adherence to HAART. At the same time, physicians estimated the current HAART adherence of their patient. MAIN OUTCOME MEASURE: Discordance between patient and physician on adherence to antiretroviral therapy. RESULTS: From May 1999 to March 2000, 320 paired patient-physician assessments were obtained. Patients had a mean plasma HIV RNA of 315 copies/ml (64% had undetectable HIV RNA) and a mean CD4+ cell count of 577 cells × 106/L. Nonadherence was reported by 30.9% of patients and estimated by physicians in 45.0% cases. In 111 cases (34.7%), patients and physicians were discordant on adherence to HAART. Kappa statistics was 0.27. Using patient-assessed adherence as reference, sensitivity, specificity, positive predictive value, and negative predictive value of physician-estimated adherence were 64.7%, 66.6%, 81.2%, and 45.8%, respectively. On multivariable analysis, low education level, unemployment, absence of a social worker in the clinical center, and unavailability of afternoon visits were significantly correlated with patient-physician discordance on adherence to antiretrovirals. CONCLUSIONS: Physicians did not correctly estimate patient-reported adherence to HAART in more than one third of patients. Both social variables and factors related to the clinical center were important predictors of discordance between patients and physicians. Interventions to enhance adherence should include strategies addressed to improve patient-physician relationship.

Published
2004

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