Search

Your search keyword '"Trono, Cosimo"' showing total 202 results
Start Over Author "Trono, Cosimo"
202 results on '"Trono, Cosimo"'

2. Long Period Fiber Grating as Immunosensor: Picomolar Detection of Immunoglobulin G

Author

Dey, Tanoy Kumar, Tombelli, Sara, Biswas, Palas, Giannetti, Ambra, Basumallick, Nandini, Baldini, Francesco, Bandyopadhyay, Somnath, Trono, Cosimo, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Di Francia, Girolamo, editor, and Di Natale, Corrado, editor

Published
2023
Full Text
View/download PDF

3. The LANER: optical networks as complex lasers

Author

Giacomelli, Giovanni, Lepri, Stefano, and Trono, Cosimo

Subjects
Physics - Optics, Condensed Matter - Disordered Systems and Neural Networks
Abstract

We discuss the main features of a new optical system capable of laser action: the active complex optical network, or lasing network (LANER). The system is experimentally realized with optical fibers linked each other with suitable optical couplers and with one or more coherent optical amplifying sections. The LANER displays a standard laser behavior: when the gain provided by the active sections is high enough to overcome the losses a coherent emission is produced, with a complicated intensity spectrum reflecting the structure of the network. A simple linear theoretical description is introduced and discussed, showing how the LANER can be considered as a generalization of the laser for a complicated cavity represented by the network itself. The system can be mapped to directed graphs and permits to disclosure the analogies with the problem of quantum chaos on graphs. In the case the links are all integer multiples of the same length, it is shown that the LANER framework corresponds to a lattice problem, with the equivalence of the Brillouin zone with the cavity Free Spectral Range. Experimental realizations of different configurations are presented and examples of spectra are reported, in a phenomenological agreement with the numerical findings of the theory., Comment: Submitted to Phys.Rev.E

Published
2018
Full Text
View/download PDF

4. An integrated device for fast and sensitive immunosuppressant detection

Author

Tombelli, Sara, Trono, Cosimo, Berneschi, Simone, Berrettoni, Chiara, Giannetti, Ambra, Bernini, Romeo, Persichetti, Gianluca, Testa, Genni, Orellana, Guillermo, Salis, Francesca, Weber, Susanne, Luppa, Peter B., Porro, Giampiero, Quarto, Giovanna, Schubert, Markus, Berner, Marcel, Freitas, Paulo P., Cardoso, Susana, Franco, Fernando, Silverio, Vânia, Lopez-Martinez, Maria, Hilbig, Urs, Freudenberger, Kathrin, Gauglitz, Günter, Becker, Holger, Gärtner, Claudia, O’Connell, Mark T., and Baldini, Francesco

Published
2022
Full Text
View/download PDF

6. Complex active optical networks as a new laser concept

Author

Lepri, Stefano, Trono, Cosimo, and Giacomelli, Giovanni

Subjects
Physics - Optics, Condensed Matter - Disordered Systems and Neural Networks, Nonlinear Sciences - Chaotic Dynamics
Abstract

Complex optical networks containing one or more gain sections are investigated and the evidence of lasing action is reported; the emission spectrum reflects the topological disorder induced by the connections. A theoretical description well compares with the measurements, mapping the networks to directed graphs and showing the analogies with the problem of quantum chaos on graphs. We show that the interplay of chaotic diffusion and amplification leads to an emission statistics with characteristic heavy-tails: for different topologies, an unprecedented experimental demonstration of Levy statistics expected for random lasers is here provided for a continuous-wave pumped system. This result is also supported by a Monte-Carlo simulation based on ray random walk on the graph., Comment: To be published in Phys. Rev. Lett

Published
2017
Full Text
View/download PDF

15. Biosensing with optical fiber gratings

Author

Chiavaioli Francesco, Baldini Francesco, Tombelli Sara, Trono Cosimo, and Giannetti Ambra

Subjects
long-period grating, tilted fiber bragg grating, etched fiber bragg grating, nanocoating, nanostructure, Physics, QC1-999
Abstract

Optical fiber gratings (OFGs), especially long-period gratings (LPGs) and etched or tilted fiber Bragg gratings (FBGs), are playing an increasing role in the chemical and biochemical sensing based on the measurement of a surface refractive index (RI) change through a label-free configuration. In these devices, the electric field evanescent wave at the fiber/surrounding medium interface changes its optical properties (i.e. intensity and wavelength) as a result of the RI variation due to the interaction between a biological recognition layer deposited over the fiber and the analyte under investigation. The use of OFG-based technology platforms takes the advantages of optical fiber peculiarities, which are hardly offered by the other sensing systems, such as compactness, lightness, high compatibility with optoelectronic devices (both sources and detectors), and multiplexing and remote measurement capability as the signal is spectrally modulated. During the last decade, the growing request in practical applications pushed the technology behind the OFG-based sensors over its limits by means of the deposition of thin film overlays, nanocoatings, and nanostructures, in general. Here, we review efforts toward utilizing these nanomaterials as coatings for high-performance and low-detection limit devices. Moreover, we review the recent development in OFG-based biosensing and identify some of the key challenges for practical applications. While high-performance metrics are starting to be achieved experimentally, there are still open questions pertaining to an effective and reliable detection of small molecules, possibly up to single molecule, sensing in vivo and multi-target detection using OFG-based technology platforms.

Published
2017
Full Text
View/download PDF

20. An integrated device for fast and sensitive immunosuppressant detection

Author

Tombelli, Sara, primary, Trono, Cosimo, additional, Berneschi, Simone, additional, Berrettoni, Chiara, additional, Giannetti, Ambra, additional, Bernini, Romeo, additional, Persichetti, Gianluca, additional, Testa, Genni, additional, Orellana, Guillermo, additional, Salis, Francesca, additional, Weber, Susanne, additional, Luppa, Peter B., additional, Porro, Giampiero, additional, Quarto, Giovanna, additional, Schubert, Markus, additional, Berner, Marcel, additional, Freitas, Paulo P., additional, Cardoso, Susana, additional, Franco, Fernando, additional, Silverio, Vânia, additional, Lopez-Martinez, Maria, additional, Hilbig, Urs, additional, Freudenberger, Kathrin, additional, Gauglitz, Günter, additional, Becker, Holger, additional, Gärtner, Claudia, additional, O’Connell, Mark T., additional, and Baldini, Francesco, additional

Published
2021
Full Text
View/download PDF

25. An integrated device for fast and sensitive immunosuppressant detection

Author

Tombelli, Sara, Trono, Cosimo, Berneschi, Simone, Berrettoni, Chiara, Giannetti, Ambra, Bernini, Romeo, Persichetti, Gianluca, Testa, Genni, Orellana, Guillermo, Salis, Francesca, Weber, Susanne, Luppa, Peter B., Porro, Giampiero, Quarto, Giovanna, Schubert, Markus, Berner, Marcel, Freitas, Paulo P., Cardoso, Susana, Franco, Fernando, Silverio, Vania, Lopez-Martinez, Maria, Hilbig, Urs, Freudenberger, Kathrin, Gauglitz, Gunter, Becker, Holger, Gartner, Claudia, O'Connell, Mark T., and Baldini, Francesco

Subjects
Cyclosporine A, Mycophenolic acid, POCT, Fluorescence, Immunosuppressant
Abstract

The present paper describes a compact point of care (POC) optical device for therapeutic drug monitoring (TDM). The core of the device is a disposable plastic chip where an immunoassay for the determination of immunosuppressants takes place. The chip is designed in order to have ten parallel microchannels allowing the simultaneous detection of more than one analyte with replicate measurements. The device is equipped with a microfluidic system, which provides sample mixing with the necessary chemicals and pumping samples, reagents and buffers into the measurement chip, and with integrated thin film amorphous silicon photodiodes for the fluorescence detection. Submicrometric fluorescent magnetic particles are used as support in the immunoassay in order to improve the efficiency of the assay. In particular, the magnetic feature is used to concentrate the antibody onto the sensing layer leading to a much faster implementation of the assay, while the fluorescent feature is used to increase the optical signal leading to a larger optical dynamic change and consequently a better sensitivity and a lower limit of detection. The design and development of the whole integrated optical device are here illustrated. In addition, detection of mycophenolic acid and cyclosporine A in spiked solutions and in microdialysate samples from patient blood with the implemented device are reported.

Published
2021
Full Text
View/download PDF

28. Immunosuppressant quantification in intravenous microdialysate – towards novel quasi-continuous therapeutic drug monitoring in transplanted patients

Author

Weber, Susanne, primary, Tombelli, Sara, additional, Giannetti, Ambra, additional, Trono, Cosimo, additional, O’Connell, Mark, additional, Wen, Ming, additional, Descalzo, Ana B., additional, Bittersohl, Heike, additional, Bietenbeck, Andreas, additional, Marquet, Pierre, additional, Renders, Lutz, additional, Orellana, Guillermo, additional, Baldini, Francesco, additional, and Luppa, Peter B., additional

Published
2020
Full Text
View/download PDF

42. SiO2-SnO2 transparent glass-ceramics activated by rare earth ions

Author

Zur, Lidia, primary, Tran, Lam Thi Ngoc, additional, Massella, Damiano, additional, Vaccari, Alessandro, additional, Chiappini, Andrea, additional, Chiasera, Alessandro, additional, Varas, Stefano, additional, Armellini, Cristina, additional, Carpentiero, Alessandro, additional, Boulard, Brigitte, additional, Dorosz, Dominik, additional, Pelli, Stefano, additional, Trono, Cosimo, additional, Berneschi, Simone, additional, Nunzi Conti, Gualtiero, additional, Gates, James, additional, Sazio, Pier-John, additional, Rossi, Barbara, additional, Iacob, Erica, additional, Micheli, Victor, additional, Speranza, Giorgio, additional, Ischia, Gloria, additional, Prudenzano, Francesco, additional, Lukowiak, Anna, additional, Zonta, Daniele, additional, Ramponi, Roberta, additional, Righini, Giancarlo C., additional, and Ferrari, Maurizio, additional

Published
2019
Full Text
View/download PDF

45. Immunosuppressant quantification in intravenous microdialysate – towards novel quasi-continuous therapeutic drug monitoring in transplanted patients.

Author

Weber, Susanne, Tombelli, Sara, Giannetti, Ambra, Trono, Cosimo, O'Connell, Mark, Wen, Ming, Descalzo, Ana B., Bittersohl, Heike, Bietenbeck, Andreas, Marquet, Pierre, Renders, Lutz, Orellana, Guillermo, Baldini, Francesco, and Luppa, Peter B.

Subjects
DRUG monitoring, TANDEM mass spectrometry, PATIENT monitoring, LIQUID chromatography-mass spectrometry, MEDICAL personnel, IMMUNOSUPPRESSIVE agents, DRUG dosage, MYCOPHENOLIC acid
Abstract

Therapeutic drug monitoring (TDM) plays a crucial role in personalized medicine. It helps clinicians to tailor drug dosage for optimized therapy through understanding the underlying complex pharmacokinetics and pharmacodynamics. Conventional, non-continuous TDM fails to provide real-time information, which is particularly important for the initial phase of immunosuppressant therapy, e.g., with cyclosporine (CsA) and mycophenolic acid (MPA). We analyzed the time course over 8 h of total and free of immunosuppressive drug (CsA and MPA) concentrations measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 16 kidney transplant patients. Besides repeated blood sampling, intravenous microdialysis was used for continuous sampling. Free drug concentrations were determined from ultracentrifuged EDTA-plasma (UC) and compared with the drug concentrations in the respective microdialysate (µD). µDs were additionally analyzed for free CsA using a novel immunosensor chip integrated into a fluorescence detection platform. The potential of microdialysis coupled with an optical immunosensor for the TDM of immunosuppressants was assessed. Using LC-MS/MS, the free concentrations of CsA (fCsA) and MPA (fMPA) were detectable and the time courses of total and free CsA comparable. fCsA and fMPA and area-under-the-curves (AUCs) in µDs correlated well with those determined in UCs (r≥0.79 and r≥0.88, respectively). Moreover, fCsA in µDs measured with the immunosensor correlated clearly with those determined by LC-MS/MS (r=0.82). The new microdialysis-supported immunosensor allows real-time analysis of immunosuppressants and tailor-made dosing according to the AUC concept. It readily lends itself to future applications as minimally invasive and continuous near-patient TDM. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

46. Femtomolar Detection by Nanocoated Fiber Label-Free Biosensors

Author

Chiavaioli, Francesco, primary, Zubiate, Pablo, additional, Del Villar, Ignacio, additional, Zamarreño, Carlos R., additional, Giannetti, Ambra, additional, Tombelli, Sara, additional, Trono, Cosimo, additional, Arregui, Francisco J., additional, Matias, Ignacio R., additional, and Baldini, Francesco, additional

Published
2018
Full Text
View/download PDF

49. SiO2-SnO2 transparent glass-ceramics activated by rare earth ions.

Author

Zur, Lidia, Lam Thi Ngoc Tran, Massella, Damiano, Vaccari, Alessandro, Chiappini, Andrea, Chiasera, Alessandro, Varas, Stefano, Armellini, Cristina, Carpentiero, Alessandro, Boulard, Brigitte, Dorosz, Dominik, Pelli, Stefano, Trono, Cosimo, Berneschi, Simone, Conti, Gualtiero Nunzi, Gates, James, Sazio, Pier-John, Rossi, Barbara, Iacob, Erica, and Micheli, Victor

Published
2018
Full Text
View/download PDF

50. Long-period fiber grating: a specific design for biosensing applications

Author

Bandyopadhyay, Sankhyabrata, primary, Biswas, Palas, additional, Chiavaioli, Francesco, additional, Dey, Tanoy Kumar, additional, Basumallick, Nandini, additional, Trono, Cosimo, additional, Giannetti, Ambra, additional, Tombelli, Sara, additional, Baldini, Francesco, additional, and Bandyopadhyay, Somnath, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results