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1. List of contributors

Author

Aimo, Cristina, primary, Aronico, Nicola, additional, Auricchio, Renata, additional, Barone, Michele, additional, Biagi, Federico, additional, Bianchi, Paola Ilaria, additional, Bibbò, Stefano, additional, Broglio, Giacomo, additional, Caio, Giacomo, additional, Calabrese, Emma, additional, Cammarota, Giovanni, additional, Caproni, Marzia, additional, Carroccio, Antonio, additional, Castellaneta, Stefania, additional, Catassi, Carlo, additional, Catassi, Giulia, additional, Ciacci, Carolina, additional, Ciccocioppo, Rachele, additional, Copparoni, Roberto, additional, Corazza, Gino Roberto, additional, Corrà, Alberto, additional, Cristofori, Fernanda, additional, Dargenio, Vanessa Nadia, additional, De Giorgio, Roberto, additional, De Lisi, Giuseppe, additional, De Micco, Ida, additional, Di Sabatino, Antonio, additional, Di Stasio, Luigia, additional, Di Stefano, Michele, additional, Discepolo, Valentina, additional, Fasano, Alessio, additional, Francavilla, Ruggiero, additional, Gasbarrini, Antonio, additional, Gasbarrini, Giovanni, additional, Gatti, Simona, additional, Gianfrani, Carmen, additional, Giuliano, Alessandra, additional, Greco, Luigi, additional, Guandalini, Stefano, additional, Ianiro, Gianluca, additional, Lenti, Marco Vincenzo, additional, Lionetti, Elena, additional, Lucioni, Marco, additional, Maimaris, Stiliano, additional, Mamone, Gianfranco, additional, Mandile, Roberta, additional, Mansueto, Pasquale, additional, Marafini, Irene, additional, Mariotti, Elena Biancamaria, additional, Mengoli, Caterina, additional, Monteleone, Giovanni, additional, Monteleone, Ivan, additional, Neuhold, Susanna, additional, Novellino, Luisa, additional, Pilo, Caterina, additional, Plutino, Giuseppe, additional, Sansotta, Naire, additional, Santacroce, Giovanni, additional, Schiepatti, Annalisa, additional, Seidita, Aurelio, additional, Silano, Marco, additional, Troncone, Edoardo, additional, Troncone, Riccardo, additional, Vanoli, Alessandro, additional, Vitale, Serena, additional, Volta, Umberto, additional, Zanini, Annalisa, additional, and Zingone, Fabiana, additional

Published
2024
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4. International Delphi Consensus Study on disposable single-use endoscopy: A path to clinical adoption

Author

AABAKKEN, Lars, ABERE, Sarah, AKROUSH, Maisam W., AL-LEHIBI, Abed, ALBÉNIZ, Eduardo, ALKANDARI, Asma, ALMADI, Majid A., ANDERLONI, Andrea, BAPAYE, Amol, BERTRAND, Napoleon, BICK, Benjamin, BISSCHOPS, Raf, BOURKE, Michael J., BROWN, James F., BRUNO, Marco J., CHIU, Philip Wai Yan, CROAGH, Daniel, de MOURA, Eduardo Guimaraes Hourneaux, DENZER, Ulrike, EMURA, Fabian, FABBRI, Carlo, FEDOROV, Evgeny, FOCKENS, Paul, GABRIELLI, Armando, HAEFNER, Michael, HUCL, Tomas, IBRAHIM, Mostafa, IJOMA, Uchenna, KAFFES, Arthur, KASHIN, Sergey, KHASHAB, Mouen A., KHOR, Christopher, LALEMAN, Wim, LAW, Ryan, LOLLO, Gianluca, MAY, Gary R., DESALEGN MEKONNEN, Hailemichael, MOON, Jong H., MUSAH, Yusuf, MUTHUSAMY, V. Raman, MUTIGNANI, Massimiliano, MWACHIRO, Michael, NAVARRETE, Claudio, NEUHAUS, Horst, NIETO, Jose M., ONYIA, Chinwe, OYELEKE, Ganiyat Kikelomo, PEREZ-MIRANDA, Manuel, PONNUDURAI, Ryan, RAJU, Gottumukkala S., REDDY, D. Nageshwar, RÖSCH, Thomas, SAITO, Yutaka, SETHI, Amrita, SHARMA, Prateek, SIDDIQUI, Uzma D., TARANTINO, Ilaria, HOOFT, Jeanine VAN, WALLACE, Michael B., WEBSTER, George, YAHAGI, Naohisa, YUSOFF, Ian, Repici, Alessandro, Khalaf, Kareem, Troncone, Edoardo, Subramaniam, Sharmila, Hassan, Cesare, and Bhandari, Pradeep

Published
2024
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5. Digital single-operator cholangioscopy in diagnostic and therapeutic bilio-pancreatic diseases: A prospective, multicenter study

Author

Fugazza, Alessandro, Gabbiadini, Roberto, Tringali, Andrea, De Angelis, Claudio Giovanni, Mosca, Piergiorgio, Maurano, Attilio, Di Mitri, Roberto, Manno, Mauro, Mariani, Alberto, Cereatti, Fabrizio, Bertani, Helga, Sferrazza, Sandro, Donato, Giulio, Tarantino, Ilaria, Cugia, Luigi, Aragona, Giovanni, Cantù, Paolo, Mazzocchi, Alessandro, Canfora, Maria Laura, Venezia, Ludovica, Bendia, Emanuele, Maroni, Luca, Zulli, Claudio, Conte, Elisabetta, Soriani, Paola, Ligresti, Dario, Vilardo, Emmanuelle, Penagini, Roberto, Benedetti, Antonio, Arcidiacono, Paolo Giorgio, Khalaf, Kareem, Troncone, Edoardo, Costamagna, Guido, Repici, Alessandro, and Anderloni, Andrea

Published
2022
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9. International multicenter comprehensive analysis of adverse events associated with lumen-apposing metal stent placement for pancreatic fluid collection drainage

Author

Fugazza, Alessandro, Sethi, Amrita, Trindade, Arvind J., Troncone, Edoardo, Devlin, John, Khashab, Mouen A., Vleggaar, Frank P., Bogte, Auke, Tarantino, Ilaria, Deprez, Pierre H., Fabbri, Carlo, Aparicio, José Ramón, Fockens, Paul, Voermans, Rogier P., Uwe, Will, Vanbiervliet, Geoffroy, Charachon, Antoine, Packey, Christopher D., Benias, Petros C., El-Sherif, Yasser, Paiji, Christopher, Ligresti, Dario, Binda, Cecilia, Martínez, Belén, Correale, Loredana, Adler, Douglas G., Repici, Alessandro, and Anderloni, Andrea

Published
2020
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15. International Delphi Consensus Study on disposable single-use endoscopy: A path to clinical adoption

Author

Repici, Alessandro, primary, Khalaf, Kareem, additional, Troncone, Edoardo, additional, Subramaniam, Sharmila, additional, Hassan, Cesare, additional, Bhandari, Pradeep, additional, AABAKKEN, Lars, additional, ABERE, Sarah, additional, AKROUSH, Maisam W., additional, AL-LEHIBI, Abed, additional, ALBÉNIZ, Eduardo, additional, ALKANDARI, Asma, additional, ALMADI, Majid A., additional, ANDERLONI, Andrea, additional, BAPAYE, Amol, additional, BERTRAND, Napoleon, additional, BICK, Benjamin, additional, BISSCHOPS, Raf, additional, BOURKE, Michael J., additional, BROWN, James F., additional, BRUNO, Marco J., additional, CHIU, Philip Wai Yan, additional, CROAGH, Daniel, additional, de MOURA, Eduardo Guimaraes Hourneaux, additional, DENZER, Ulrike, additional, EMURA, Fabian, additional, FABBRI, Carlo, additional, FEDOROV, Evgeny, additional, FOCKENS, Paul, additional, GABRIELLI, Armando, additional, HAEFNER, Michael, additional, HUCL, Tomas, additional, IBRAHIM, Mostafa, additional, IJOMA, Uchenna, additional, KAFFES, Arthur, additional, KASHIN, Sergey, additional, KHASHAB, Mouen A., additional, KHOR, Christopher, additional, LALEMAN, Wim, additional, LAW, Ryan, additional, LOLLO, Gianluca, additional, MAY, Gary R., additional, DESALEGN MEKONNEN, Hailemichael, additional, MOON, Jong H., additional, MUSAH, Yusuf, additional, MUTHUSAMY, V. Raman, additional, MUTIGNANI, Massimiliano, additional, MWACHIRO, Michael, additional, NAVARRETE, Claudio, additional, NEUHAUS, Horst, additional, NIETO, Jose M., additional, ONYIA, Chinwe, additional, OYELEKE, Ganiyat Kikelomo, additional, Perez-MIRANDA, Manuel, additional, PONNUDURAI, Ryan, additional, RAJU, Gottumukkala S., additional, REDDY, D. Nageshwar, additional, RÖSCH, Thomas, additional, SAITO, Yutaka, additional, SETHI, Amrita, additional, SHARMA, Prateek, additional, SIDDIQUI, Uzma D., additional, TARANTINO, Ilaria, additional, HOOFT, Jeanine VAN, additional, WALLACE, Michael B., additional, WEBSTER, George, additional, YAHAGI, Naohisa, additional, and YUSOFF, Ian, additional

Published
2023
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16. Frequency and Predictors of Dysplasia in Pseudopolyp-like Colorectal Lesions in Patients with Long-Standing Inflammatory Bowel Disease

Author

De Cristofaro, Elena, primary, Lolli, Elisabetta, additional, Migliozzi, Stefano, additional, Sincovih, Stella, additional, Marafini, Irene, additional, Zorzi, Francesca, additional, Troncone, Edoardo, additional, Neri, Benedetto, additional, Biancone, Livia, additional, Del Vecchio Blanco, Giovanna, additional, Calabrese, Emma, additional, and Monteleone, Giovanni, additional

Published
2023
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18. International Delphi Consensus Study on disposable single-use endoscopy: A path to clinical adoption.

Author

Repici, Alessandro, Khalaf, Kareem, Troncone, Edoardo, Subramaniam, Sharmila, Hassan, Cesare, and Bhandari, Pradeep

Abstract

Increasing infectious rate estimates and low microbiological surveillance affect safety of gastrointestinal endoscopy globally. Single use endoscopes and accessories have been claimed to improve safety, but there is lack of data on their indication and sustainability. We aimed to identify a series of best practice recommendations for the use of single use endoscopes and accessories using a modified Delphi. Consensus statements for the use of single use endoscopy and accessories were developed using a modified Delphi process, utilizing an international endoscopist expert panel of 62 experts from 33 nations. The main steps in the process were selecting the consensus group, conducting systematic literature reviews, developing statements, and anonymous voting on the statements until consensus was reached. High-risk patients were defined as those with multi-drug-resistant infections, immunosuppressive medication or chemotherapy, post-transplantation, or with severe neutropenia. Of the 26 statements that were voted upon through two rounds, 17 statements reached consensus. Category 1: single use accessories (8 statements), related to defining recommendations for the use of single use accessories in all patient populations or high-risk patients. Category 2: clinical indication for single use endoscopes (9 statements), including indications to high-risk patients, protecting the endoscope apparatus and contamination measures in endoscopy units. Category 3: technical factors (4 statements), related to superior performance and technical specifications with the new innovation. Category 4: environmental issues (2 statements), concerning mechanisms that reduce the detrimental burden to the environment. Category 5: financial implications (3 statements), related to healthcare policies, cost neutrality and other financial associations of single use endoscopy. This is the first international initiative in determining clinical indications for single use endoscopy and accessories. The study's findings should serve as a framework for future physicians to guide future research and aid the proper evidence-based indications for the implementation of single use endoscopes in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Liver-Specific Contrast-Enhanced Magnetic Resonance Cholangio-Pancreatography (Ce-MRCP) in Non-Invasive Diagnosis of Iatrogenic Biliary Leakage

Author

Argirò, Renato, primary, Sensi, Bruno, additional, Siragusa, Leandro, additional, Bellini, Luigi, additional, Conte, Luigi Edoardo, additional, Riccetti, Camilla, additional, Del Vecchio Blanco, Giovanna, additional, Troncone, Edoardo, additional, Floris, Roberto, additional, Salavracos, Mike, additional, Tisone, Giuseppe, additional, and Anselmo, Alessandro, additional

Published
2023
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20. The PROSIT Cohort of Infliximab Biosimilar in IBD: A Prolonged Follow-up on the Effectiveness and Safety Across Italy

Author

Armuzzi, Alessandro, Fiorino, Gionata, Variola, Angela, Manetti, Natalia, Fries, Walter, Orlando, Ambrogio, Maconi, Giovanni, Bossa, Fabrizio, Cappello, Maria, Biancone, Livia, Cantoro, Laura, Costa, Francesco, D’Incà, Renata, Lionetti, Paolo, Principi, Mariabeatrice, Castiglione, Fabiana, Annunziata, Maria L, Di Sabatino, Antonio, Di Girolamo, Maria, Terpin, Maria M, Cortelezzi, Claudio C, Saibeni, Simone, Amato, Arnaldo, Ardizzone, Sandro, Guidi, Luisa, Danese, Silvio, Massella, Arianna, Ventra, Agostino, Rizzuto, Giulia, Massari, Alessandro, Perri, Francesco, Annese, Vito, Saettone, Silvia, Tari, Roberto, Petruzzellis, Carlo, Meucci, Gianmichele, Imperiali, Gianni, Guglielmi, Francesco W, Mazzuoli, Silvia, Caserta, Luigi, Caterina Parodi, Maria, Colli, Agostino, Ronchetti, Anna, Pugliese, Daniela, Geccherle, Andrea, Rogai, Francesca, Milani, Stefano, Renna, Sara, Cassinotti, Andrea, Andriulli, Angelo, Martino, Giuseppina, Scrivo, Barbara, Troncone, Edoardo, Kohn, Anna, Bertani, Lorenzo, Lorenzon, Greta, Ghione, Silvia, Nardone, Olga, Vecchi, Maurizio, Bertani, Angela, Bosani, Matteo A, Bezzio, Cristina, and Salerno, Raffaele

Published
2019
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24. Targeting IL-34/MCSF-1R Axis in Colon Cancer

Author

Monteleone, Giovanni, primary, Maresca, Claudia, additional, Colella, Marco, additional, Pacifico, Teresa, additional, Congiu, Daniele, additional, Troncone, Edoardo, additional, and Marafini, Irene, additional

Published
2022
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26. DIGITAL SINGLE-OPERATOR CHOLANGIOSCOPY IN DIAGNOSTIC AND THERAPEUTIC BILIO-PANCREATIC DISEASES: A PROSPECTIVE, MULTICENTER STUDY

Author

Fugazza, Alessandro, primary, Gabbiadini, Roberto, additional, Tringali, Andrea, additional, De Angelis, Claudio, additional, Mosca, Piergiorgio, additional, Maurano, Attilio, additional, Di Mitri, Roberto, additional, Manno, Mauro, additional, Mariani, Alberto, additional, Cereatti, Fabrizio, additional, Bertani, Helga, additional, Sferrazza, Sandro, additional, Donato, Giulio, additional, Tarantino, Ilaria, additional, Cugia, Luigi, additional, Aragona, Giovanni, additional, Cantù, Paolo, additional, Mazzocchi, Alessandro, additional, Canfora, Maria Laura, additional, Venezia, Ludovica, additional, Bendia, Emanuele, additional, Maroni, Luca, additional, Zulli, Claudio, additional, Conte, Elisabetta, additional, Soriani, Paola, additional, Ligresti, Dario, additional, Vilardo, Emanuelle, additional, Penagini, Roberto, additional, Benedetti, Antonio, additional, Arcidiacono, Paolo G., additional, Khalaf, Kareem, additional, Troncone, Edoardo, additional, Costamagna, Guido, additional, Repici, Alessandro, additional, and Anderloni, Andrea A., additional

Published
2022
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29. Transesophageal endoscopic ultrasound in the diagnosis of the lung masses: a multicenter experience with fine-needle aspiration and fine-needle biopsy needles

Author

Mangiavillano, Benedetto, primary, Spatola, Federica, additional, Facciorusso, Antonio, additional, De Nucci, Germana, additional, Ligresti, Dario, additional, Henry Eusebi, Leonardo, additional, Lisotti, Andrea, additional, Auriemma, Francesco, additional, Lamonaca, Laura, additional, Paduano, Danilo, additional, Crinò, Stefano, additional, Scarlata, Simone, additional, Troncone, Edoardo, additional, Del Vecchio Blanco, Giovanna, additional, Manes, Giampiero, additional, Traina, Mario, additional, Bertani, Alessandro, additional, Ofosu, Andrew, additional, Binda, Cecilia, additional, Fabbri, Carlo, additional, Muscatiello, Nicola, additional, Fusaroli, Pietro, additional, Repici, Alessandro, additional, and Carrara, Silvia, additional

Published
2022
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31. Endoscopic Ultrasound Plus Endoscopic Retrograde Cholangiopancreatography Based Tissue Sampling for Diagnosis of Proximal and Distal Biliary Stenosis Due to Cholangiocarcinoma: Results from a Retrospective Single-Center Study

Author

Troncone, Edoardo, primary, Gadaleta, Fabio, additional, Paoluzi, Omero Alessandro, additional, Gesuale, Cristina Maria, additional, Formica, Vincenzo, additional, Morelli, Cristina, additional, Roselli, Mario, additional, Savino, Luca, additional, Palmieri, Giampiero, additional, Monteleone, Giovanni, additional, and Del Vecchio Blanco, Giovanna, additional

Published
2022
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37. Metalloproteinases in Inflammatory Bowel Diseases

Author

Marônek,Martin, Marafini,Irene, Gardlík,Roman, Link,René, Troncone,Edoardo, and Monteleone,Giovanni

Subjects
Journal of Inflammation Research
Abstract

Martin Marônek,1,* Irene Marafini,2,* Roman Gardlík,1 René Link,3 Edoardo Troncone,2 Giovanni Monteleone2 1Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, 81108, Slovakia; 2Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, 00133, Italy; 3Institute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, Košice, 040 11, Slovakia*These authors contributed equally to this workCorrespondence: Giovanni MonteleoneDipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata”, Via Montpellier 1, Rome, 00133, ItalyTel +39 06 20903702Fax +39 06 72596391Email Gi.Monteleone@Med.uniroma2.itAbstract: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, encompassing two main disorders: Crohn’s disease (CD) and ulcerative colitis (UC). In both these pathologies, excessive and local immune response against luminal antigens promotes a pathological process leading to various degrees of gut damage. Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. In physiological conditions, MMPs are produced at very low level and generally in the latent form and are involved in the normal tissue turnover. Their function is inhibited by tissue inhibitors of metalloproteinases (TIMPs). However, in inflamed tissue of IBD patients, MMPs are produced in excess and/or the activity of TIMPs is not sufficient to block MMPs, thereby making a major contribution to the IBD-related mucosal degradation. In this review, we summarize the available evidence on the expression and role of MMPs in IBD.Keywords: tissue inhibitor of metalloproteinases, Crohn’s disease, ulcerative colitis, intestinal inflammation

Published
2021

38. The impact of COVID-19 on elective and urgent digestive endoscopic procedures: a report on a year of pandemic in a gastroenterology centre in Italy.

Author

Blanco, Giovanna Del Vecchio, Troncone, Edoardo, Grasso, Enrico, De Cristofaro, Elena, Sena, Giorgia, De Vico, Pasquale, Dauri, Mario, Monteleone, Giovanni, and Paoluzi, Omero Alessandro

Subjects
*COVID-19 pandemic, *COVID-19, *ENDOSCOPIC ultrasonography, *DELAYED diagnosis, *GASTROENTEROLOGY
Abstract

Introduction: The COVID-19 pandemic (COVID-19) affected digestive endoscopic activity worldwide. Resumption and maintenance of elective endoscopic activity are crucial to containing the impact of COVID-19 on mortality and prognosis of gastrointestinal disorders, primarily cancers. Aim: To assess the impact of COVID-19 during and after the lockdown period on endoscopic activity. Material and methods: The endoscopic activity undertaken during the COVID-19-related lockdown (March 2020-May 2020) and in the post-lockdown period (June 2020-March 2021) was compared with that in the corresponding periods of the year before COVID-19 in a gastroenterology centre in Italy. Results: During the lockdown period, there was a reduction in esophagogastroduodenoscopy (EGD), colonoscopy (CSPY), endoscopic ultrasound (EUS), and endoscopic-retrograde cholangiopancreatography (ERCP) of 75.8%, 74.8%, 60%, and 42%, respectively, compared with the corresponding period of the year before COVID-19. During the post-lockdown period to date, EGD, CSPY, EUS, and ERCP increased as compared to the lockdown period (30.6%, 50.6%, 33.6%, and 65.4%, respectively), but only ERCP showed a full recovery when compared with the corresponding period of the year before COVID-19. Conclusions: Endoscopic activity decreased significantly during the COVID-19 lockdown, and only ERCP had a full recovery in the post-lockdown period. The pandemic-related limitations and the backlog of endoscopic procedures represent important reasons for the increased risk or delayed diagnosis of GI cancers. [ABSTRACT FROM AUTHOR]

Published
2022
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39. GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation

Author

Laudisi, Federica, primary, Stolfi, Carmine, additional, Bevivino, Gerolamo, additional, Maresca, Claudia, additional, Franzè, Eleonora, additional, Troncone, Edoardo, additional, Lolli, Elisabetta, additional, Marafini, Irene, additional, Pietrucci, Daniele, additional, Teofani, Adelaide, additional, Di Grazia, Antonio, additional, Di Fusco, Davide, additional, Colantoni, Alfredo, additional, Ortenzi, Angela, additional, Desideri, Alessandro, additional, Monteleone, Ivan, additional, and Monteleone, Giovanni, additional

Published
2021
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40. Efficacy and tolerability of very low-volume bowel preparation in patients with inflammatory bowel diseases

Author

Neri, Benedetto, primary, Scarozza, Patrizio, additional, Giannarelli, Diana, additional, Sena, Giorgia, additional, Mossa, Michelangela, additional, Lolli, Elisabetta, additional, Calabrese, Emma, additional, Biancone, Livia, additional, Grasso, Enrico, additional, Di Iorio, Laura, additional, Troncone, Edoardo, additional, Monteleone, Giovanni, additional, Paoluzi, Omero Alessandro, additional, and Del Vecchio Blanco, Giovanna, additional

Published
2021
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43. Novel Therapeutic Options for People with Ulcerative Colitis: An Update on Recent Developments with Janus Kinase (JAK) Inhibitors

Author

Troncone,Edoardo, Marafini,Irene, Del Vecchio Blanco,Giovanna, Di Grazia,Antonio, and Monteleone,Giovanni

Subjects
Clinical and Experimental Gastroenterology
Abstract

Edoardo Troncone, Irene Marafini, Giovanna Del Vecchio Blanco, Antonio Di Grazia, Giovanni Monteleone Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, ItalyCorrespondence: Giovanni MonteleoneDipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata”, Via Montpellier, 1, Rome 00133, ItalyTel +390620903702Fax +390672596391Email Gi.Monteleone@Med.uniroma2.itAbstract: Crohn’s disease (CD) and ulcerative colitis (UC), the main forms of inflammatory bowel disease(IBD) in human beings, are chronic relapsing-remitting disorders of the gastrointestinal tract, which usually require lifelong therapies. For many years, IBD have been managed with corticosteroids, aminosalicylates and immunosuppressants (ie, thiopurines). The advent of biologic therapies (anti-TNF-α agents) has significantly improved the outcome of IBD patients in terms of prolonged clinical remission, corticosteroid sparing, achievement of mucosal healing and prevention of disease-related complications. Nevertheless, primary failure or loss of response to biologics occur in about 50% of patients treated with these drugs. Therefore, the need for new effective treatments for such patients has critically emerged as an urgent priority. With this regard, several small-molecule drugs (SMDs) targeting lymphocyte trafficking (ie, sphingosine-1-phosphate receptor modulators) and the JAK/STAT pathway (eg, tofacitinib) have been recently developed and tested in IBD. In particular, JAK inhibitors are oral compounds characterized by short half-life, low antigenicity and the ability to dampen several pro-inflammatory pathways simultaneously. Tofacitinib, a pan-JAK inhibitor, has shown good efficacy and safety in UC clinical trials and has been recently approved for the treatment of UC patients. In this review, we analyze the main evidence supporting the use of JAK inhibitors in UC and explore the unanswered questions about the use of this class of drug in UC.Keywords: inflammatory bowel disease, tofacitinib, JAK/STAT pathway, small molecule drugs

Published
2020

45. International multicenter comprehensive analysis of adverse events associated with lumen-apposing metal stent placement for pancreatic fluid collection drainage.

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Fugazza, Alessandro, Sethi, Amrita, Trindade, Arvind J, Troncone, Edoardo, Devlin, John, Khashab, Mouen A, Vleggaar, Frank P, Bogte, Auke, Tarantino, Ilaria, Deprez, Pierre Henri, Fabbri, Carlo, Aparicio, José Ramón, Fockens, Paul, Voermans, Rogier P, Uwe, Will, Vanbiervliet, Geoffroy, Charachon, Antoine, Packey, Christopher D, Benias, Petros C, El-Sherif, Yasser, Paiji, Christopher, Ligresti, Dario, Binda, Cecilia, Martínez, Belén, Correale, Loredana, Adler, Douglas G, Repici, Alessandro, Anderloni, Andrea, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Fugazza, Alessandro, Sethi, Amrita, Trindade, Arvind J, Troncone, Edoardo, Devlin, John, Khashab, Mouen A, Vleggaar, Frank P, Bogte, Auke, Tarantino, Ilaria, Deprez, Pierre Henri, Fabbri, Carlo, Aparicio, José Ramón, Fockens, Paul, Voermans, Rogier P, Uwe, Will, Vanbiervliet, Geoffroy, Charachon, Antoine, Packey, Christopher D, Benias, Petros C, El-Sherif, Yasser, Paiji, Christopher, Ligresti, Dario, Binda, Cecilia, Martínez, Belén, Correale, Loredana, Adler, Douglas G, Repici, Alessandro, and Anderloni, Andrea

Abstract

BACKGROUND AND AIMS: High rates of technical and clinical success were reported for lumen-apposing metal stent (LAMS) placement for peripancreatic fluid collection (PFC) drainage. However, data on the adverse event (AE) rates are heterogeneous. The aim of this study was to evaluate the incidence, severity, management, and risk factors of AEs related to the use of LAMSs for drainage of PFCs in a large cohort of patients. METHODS: This is a multicenter, international, retrospective review from 15 centers of all patients who underwent placement of LAMSs for the management of PFCs. A nested case-control study was conducted in patients with (case) or without (control) AEs. RESULTS: Three hundred thirty-three procedures in 328 patients were performed (5 patients treated with 2 LAMSs). Technical success was achieved in 321 patients (97.9%). Three hundred four patients were finally included in the study (7 excluded for lost to follow-up information; 10 excluded for deaths unrelated to LAMSs). The rate of clinical success was 89.5%. Seventy-nine LAMS-related AEs occurred in 74 of 304 patients (24.3%), after a mean time of 25.3 days (median, 18 days; interquartile range, 6-30) classified as 20 (25.3%) mild, 54 (68.4%) moderate, or 5 (6.3%) severe. On multivariable analysis compared with control subjects, cases were more likely to have walled-off necrosis (WON) versus pancreatic pseudocysts (odds ratio, 2.18; 95% confidence interval, 1.09-4.46; P = .028), whereas cases were less likely to have undergone tract (balloon) dilation (yes vs no; odds ratio, .47; 95% confidence interval, .22-.93; P = .034). CONCLUSIONS: Data from this large international retrospective study confirm that the use of LAMSs for management of PFCs has excellent technical and good clinical success rates. The rate of AEs, however, is not negligible and should be carefully considered before using these stents for drainage of PFCs and in particular for WON. Further prospective studies are needed to confirm th

Published
2020

46. International multicenter comprehensive analysis of adverse events associated with lumen-apposing metal stent placement for pancreatic fluid collection drainage

Author

MS MDL 1, MS MDL Oncologie, Cancer, Fugazza, Alessandro, Sethi, Amrita, Trindade, Arvind J, Troncone, Edoardo, Devlin, John, Khashab, Mouen A, Vleggaar, Frank P, Bogte, Auke, Tarantino, Ilaria, Deprez, Pierre H, Fabbri, Carlo, Aparicio, José Ramón, Fockens, Paul, Voermans, Rogier P, Uwe, Will, Vanbiervliet, Geoffroy, Charachon, Antoine, Packey, Christopher D, Benias, Petros C, El-Sherif, Yasser, Paiji, Christopher, Ligresti, Dario, Binda, Cecilia, Martínez, Belén, Correale, Loredana, Adler, Douglas G, Repici, Alessandro, Anderloni, Andrea, MS MDL 1, MS MDL Oncologie, Cancer, Fugazza, Alessandro, Sethi, Amrita, Trindade, Arvind J, Troncone, Edoardo, Devlin, John, Khashab, Mouen A, Vleggaar, Frank P, Bogte, Auke, Tarantino, Ilaria, Deprez, Pierre H, Fabbri, Carlo, Aparicio, José Ramón, Fockens, Paul, Voermans, Rogier P, Uwe, Will, Vanbiervliet, Geoffroy, Charachon, Antoine, Packey, Christopher D, Benias, Petros C, El-Sherif, Yasser, Paiji, Christopher, Ligresti, Dario, Binda, Cecilia, Martínez, Belén, Correale, Loredana, Adler, Douglas G, Repici, Alessandro, and Anderloni, Andrea

Published
2020

47. Factors influencing diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in pancreatic and biliary tumors

Author

Del Vecchio Blanco, Giovanna, primary, Palmieri, Giampiero, additional, Giannarelli, Diana, additional, Formica, Vincenzo, additional, Portarena, Ilaria, additional, Nardecchia, Antonella, additional, Troncone, Edoardo, additional, Benassi, Michela, additional, Giudice, Emilia, additional, Anselmo, Alessandro, additional, Tisone, Giuseppe, additional, Roselli, Mario, additional, Monteleone, Giovanni, additional, and Paoluzi, Omero Alessandro, additional

Published
2021
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