504 results on '"Tron, Gian Cesare"'
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2. Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcusaureus
3. Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction
4. Front Cover: Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions (Chem. Eur. J. 20/2024)
5. Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists
6. Exploiting the Different Nucleophilicity of the Isocyano Group: A Strategy for the Isocyanide Functionalization.
7. Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions.
8. Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group
9. Click 1,2,3-triazoles in drug discovery and development: From the flask to the clinic?
10. Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening
11. Sulfur‐Centered Radicals in Visible Light Isocyanide Photochemistry
12. Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction
13. Figure S4 from Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells
14. Data from Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells
15. Supplementary Materials and Methods from Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells
16. Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
17. Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs?
18. Design of Multi-Component Reactions
19. Novel Reagents for Multi-Component Reactions
20. Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity
21. Visible-Light Photoredox Catalysis in Water.
22. Visible-Light Photoredox Catalysis in Water
23. Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization
24. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus
25. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
26. Visible-light photocatalytic metal-free multicomponent Ugi-like chemistry
27. In-water synthesis of isocyanides under micellar conditions
28. Multicomponent reaction between (Z)-chloroximes, isocyanides and NH-heterocyclic rings
29. The Dark Side of Isocyanides: Visible-Light Photocatalytic Activity in the Oxidative Functionalization of C(sp3)–H Bonds
30. Photomicellar Catalyzed Synthesis of Amides from Isocyanides: Optimization, Scope, and NMR Studies of Photocatalyst/Surfactant Interactions
31. Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds
32. Visible-Light Photocatalytic Ugi/Aza-Wittig Cascade towards 2-Aminomethyl-1,3,4-oxadiazole Derivatives
33. Medicinal Chemistry of Isocyanides
34. Icilio Guareschi and his amazing “1897 reaction”
35. Tritylamine as an Ammonia Surrogate in the Ugi Reaction Provides Access to Unprecedented 5-Sulfamido Oxazoles Using Burgess-type Reagents
36. What’s in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications
37. Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition
38. The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications
39. Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds
40. Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry
41. Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals
42. Novel Reagents for Multi-Component Reactions
43. Design of Multi-Component Reactions
44. Identification of Novel Antitubulin Agents by Using a Virtual Screening Approach Based on a 7-Point Pharmacophore Model of the Tubulin Colchi-Site
45. Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy
46. Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists?
47. Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
48. Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans
49. Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles
50. Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors
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