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1. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

Author

Anderson, Craig S, primary, Huang, Yining, additional, Lindley, Richard I, additional, Chen, Xiaoying, additional, Arima, Hisatomi, additional, Chen, Guofang, additional, Li, Qiang, additional, Billot, Laurent, additional, Delcourt, Candice, additional, Bath, Philip M, additional, Broderick, Joseph P, additional, Demchuk, Andrew M, additional, Donnan, Geoffrey A, additional, Durham, Alice C, additional, Lavados, Pablo M, additional, Lee, Tsong-Hai, additional, Levi, Christopher, additional, Martins, Sheila O, additional, Olavarria, Veronica V, additional, Pandian, Jeyaraj D, additional, Parsons, Mark W, additional, Pontes-Neto, Octavio M, additional, Ricci, Stefano, additional, Sato, Shoichiro, additional, Sharma, Vijay K, additional, Silva, Federico, additional, Song, Lili, additional, Thang, Nguyen H, additional, Wardlaw, Joanna M, additional, Wang, Ji-Guang, additional, Wang, Xia, additional, Woodward, Mark, additional, Chalmers, John, additional, Robinson, Thompson G, additional, Anderson, Craig S., additional, Lindley, Richard I., additional, Bath, Philip M., additional, Broderick, Joseph P., additional, Demchuk, Andrew M., additional, Donnan, Geoffrey A., additional, Durham, Alice C., additional, Lavados, Pablo M., additional, Martins, Sheila O., additional, Olavarria, Veronica V., additional, Pandian, Jeyaraj D., additional, Parsons, Mark W., additional, Pontes-Neto, Octavio M., additional, Sharma, Vijay K., additional, Thang, Nguyen H., additional, Wardlaw, Joanna M., additional, Robinson, Thompson G., additional, Kim, Jong S., additional, Stapf, Christian, additional, Simes, R. John, additional, Hankey, Graeme J., additional, Sandercock, Peter, additional, Bousser, Marie-Germaine, additional, Wong, K.S. Lawrence, additional, Scaria, Anish, additional, Hirakawa, Yoichiro, additional, Moullaali, Tom J., additional, Carcel, Cheryl, additional, Gordon, Penny, additional, Fuentes-Patarroyo, Sully X., additional, Benito, Dino, additional, Chen, Ruiqi, additional, Cao, Yongjun, additional, Kunchok, Amy, additional, Winters, Stephen, additional, Coutts, Shelagh, additional, Yoshimura, Sohei, additional, You, Shoujiang, additional, Yang, Jie, additional, Wu, Guojun, additional, Zhang, Shihong, additional, Manning, Lisa, additional, Mistri, Amit, additional, Haunton, Victoria, additional, Minhas, Jatinder, additional, Malavera, Alejandra, additional, Lim, Joyce, additional, Liu, Leibo, additional, Kumar, Namrata N., additional, Tay, Nicole, additional, Jenson, Kerry, additional, Richtering, Sarah, additional, Tucker, Sharon, additional, Knight, Elizabeth, additional, Ivanova, Elizaveta, additional, Thembani, Emma, additional, Odgers, Elizabeth, additional, Sanders, Elizabeth, additional, Small, Sabrina, additional, Vaghasiya, Ruchita, additional, Armenis, Manuela, additional, Donnelly, Paul, additional, Baig, Merza A., additional, Blacklock, Nick, additional, Naidu, Bala, additional, Monaghan, Helen, additional, Smith, Phillipa, additional, Glass, Parisa, additional, Bai, Xuejie, additional, Li, Qiancheng, additional, Zhu, Pingping, additional, Kong, Liang, additional, He, Ruihong, additional, Zhao, He, additional, Lv, Jiajie, additional, Jia, Haijing, additional, Xi, Zhen, additional, Cong, Yuhan, additional, Cui, Buliang, additional, Deng, Hua, additional, Guo, Ying, additional, He, Lingyu, additional, Jia, Ruolan, additional, Li, Nan, additional, Li, Wei, additional, Liu, Mengxiao, additional, Zhang, Meng, additional, Xu, Ziwei, additional, Zhang, Ting, additional, Zhao, Yan, additional, Gregory, Philip, additional, In, Yunjeong, additional, Kim, Su J., additional, Ahn, Jung E., additional, Kim, Sul H., additional, Hong, Young L., additional, González-McCawley, Francisca, additional, Martins, Magda C.O., additional, Portales, Bernardita, additional, Wang, Ching-Yi, additional, Ryu, Shan-Jen, additional, Aujla, Hardeep, additional, Lewin, Sue, additional, Kumar, Tracy, additional, Barrows, Sara, additional, Ebraimo, Ahtasam, additional, Uyen, Hong H., additional, Giang, Nguyen A., additional, Linh, Le T.M., additional, An, Le T.T., additional, Phuong, Do M., additional, Ngoc, Pham V.B., additional, Hang, Nguyen M., additional, Tran, Nguyen T.B., additional, Hien, Ha T.T., additional, Yen, Mai B., additional, Tram, Ngo T.B., additional, Truc, Tran T.T., additional, Hoa, Nguyen A., additional, Thuan, Nguyen T.B., additional, Oanh, Ha T.K., additional, Arora, Deepti, additional, Verma, Shweta J., additional, Krause, M., additional, Priglinger, M., additional, Day, S., additional, Jala, S., additional, Davies, L., additional, Ray, E., additional, Celestino, S., additional, Law, L.Y., additional, Wijeratne, T., additional, Ng, G., additional, Nagao, K., additional, Weiss, G., additional, Titton, N., additional, Batista, C., additional, Zãn, D., additional, Carbonera, L., additional, Ferreira, K., additional, Castro, R., additional, Martins Filho, R.K., additional, Carvalho, M., additional, Libardi, M., additional, Martins, G., additional, Fagundes, D., additional, Baron, G., additional, Boehringer, A., additional, Barbosa, J., additional, Bazan, R., additional, Braga, G., additional, Luvizutto, G., additional, Ribeiro, P., additional, Winckler, F., additional, Moro, C., additional, Longo, A., additional, Liberato, R., additional, Barbosa, R., additional, Magalhães, P., additional, Portal, M., additional, Martin, K., additional, Souza, A., additional, Cuervo, D., additional, Perin, D., additional, Marques, L., additional, Oliveira, F., additional, Battaglini, M., additional, Lourenço, F., additional, Silva, G., additional, Duarte, L., additional, Alves, M., additional, Sousa, J., additional, Uhehara, M., additional, Brunser, A., additional, Mazzón, E., additional, Spencer, M., additional, Acosta, I., additional, Rojo, A., additional, Rivas, R., additional, Klapp, C., additional, Carvallo, L., additional, Carvallo, P., additional, Mansilla, E., additional, Flores, J., additional, Alvarado, M., additional, Herrera, A., additional, Reyes, C., additional, Jurado, F., additional, Bustamante, G., additional, Bravo, L., additional, Matamala, J.M., additional, Guerrero, R., additional, Zhou, S., additional, Ping, L., additional, Liu, W., additional, Liu, L., additional, Tian, Y., additional, Xu, H., additional, Wang, J., additional, Wang, L., additional, Zhen, Z., additional, Zhang, J., additional, Yan, M., additional, Zhang, Q., additional, Tao, X., additional, Liu, C., additional, Shi, J., additional, Zhang, X., additional, Tai, L., additional, Xu, L., additional, Lu, H., additional, Nie, H., additional, Li, X., additional, Zhou, J., additional, Liu, Y., additional, Gong, P., additional, Zhao, H., additional, Li, R., additional, Wang, X., additional, Chen, Q., additional, Li, Y., additional, Wu, L., additional, Jia, L., additional, Guo, X., additional, Chen, G., additional, Lin, B., additional, Zhu, W., additional, Yang, K., additional, Zhang, Z., additional, Xie, C., additional, Wu, D., additional, Wang, Y., additional, Liu, D., additional, Liu, Z., additional, Liang, L., additional, Cao, Q., additional, Xia, J., additional, Weng, Y., additional, Li, J., additional, Xu, T., additional, Geng, D., additional, Yan, X., additional, Wang, D., additional, Zhao, N., additional, Tang, Z., additional, Yin, W., additional, Wang, S., additional, Huang, W., additional, Yang, Y., additional, Song, A., additional, Hao, Y., additional, Zhang, A., additional, Qiao, B., additional, Yang, J., additional, Yan, H., additional, Wei, X., additional, Tao, Z., additional, Liu, H., additional, Lv, Y., additional, Yang, H., additional, Han, L., additional, Mao, X., additional, Ge, L., additional, Zhang, Y., additional, He, S., additional, Jiang, J., additional, Wu, W., additional, Wang, H., additional, Yang, L., additional, Tang, Y., additional, Sun, H., additional, Li, F., additional, Li, G., additional, Sun, Y., additional, Zhang, H., additional, Wu, Y., additional, Huang, L., additional, Geng, C., additional, Jin, Z., additional, Zhu, J., additional, Zhang, F., additional, Zheng, R., additional, Shen, H., additional, Liu, F., additional, Chen, C., additional, Chen, S., additional, Zhou, L., additional, Hu, B., additional, Zou, Z., additional, Liu, J., additional, Chang, X., additional, Zhang, S., additional, Huang, Q., additional, Liu, X., additional, Liu, S., additional, He, W., additional, Feng, J., additional, Li, L., additional, Chen, X., additional, Zhuang, X., additional, Zheng, W., additional, Lai, Y., additional, Zhou, Y., additional, Duan, H., additional, Yang, Q., additional, Du, J., additional, Lin, Q, additional, Xu, E., additional, Zhan, L., additional, Wu, J., additional, Feng, X., additional, Wei, C., additional, He, J., additional, Wang, B., additional, Li, W, additional, Chen, P, additional, Guo, F, additional, Dai, H, additional, Dai, M, additional, Zeng, X., additional, Chen, B., additional, Long, F., additional, Su, Q., additional, Bao, B., additional, Wu, T., additional, Wu, X., additional, Shao, Y., additional, Li, S., additional, Xu, Y., additional, Castellanos, J.A., additional, Muñoz-Collazos, M., additional, Solano, E., additional, Leung, W.H.T., additional, Sureshbabu, S., additional, Sharma, S.N., additional, George, S., additional, Shekhar, S., additional, Singla, S., additional, Saini, L., additional, Sunita, -, additional, Kate, M., additional, Sarvotham, R., additional, William, A.G., additional, Deepak, A., additional, BK, M., additional, Benny, R., additional, Bolegave, V., additional, Basle, M., additional, Gore, S., additional, George, P., additional, Kumaravelu, S., additional, Rahamath, S., additional, Raj, P.G., additional, Devi, A.R., additional, Sharma, A., additional, Prajapati, J., additional, Parmar, M., additional, Patel, D., additional, Panchal, T., additional, Gorthi, S.P., additional, Prabhu, V., additional, Prabhu, A., additional, Chandran, V., additional, Chatterjee, A., additional, Nair, R., additional, Nambiar, V.K., additional, TS, D., additional, TP, S., additional, Ajai, V., additional, Paul, S., additional, Natarajan, P.C., additional, Chittibabu, D., additional, Borah, N.C., additional, Ghose, M., additional, Choudhury, N., additional, Gohain, P., additional, Kalita, K., additional, Duberkar, D., additional, Pawar, N., additional, Bhaviskar, R., additional, Caterbi, E., additional, Cenciarelli, S., additional, Condurso, R., additional, Gallinella, E., additional, Greco, L., additional, Marando, C., additional, Mastrocola, S., additional, Mattioni, A., additional, Sacchini, E., additional, Sicilia, I., additional, Gallina, A., additional, Giannandrea, D., additional, Marsili, E., additional, Mazzoli, T., additional, Padiglioni, C., additional, Corea, F., additional, Guidubaldi, A., additional, Micheli, S., additional, Barbi, M., additional, Kim, J., additional, Song, H.J., additional, Jeong, H.S., additional, Lim, J.G., additional, Park, S.M., additional, Lee, K.B., additional, Hwang, H.W., additional, Kwon, S.U., additional, Kang, D.W., additional, Kim, Y.J., additional, Kim, B.J., additional, Park, J.M., additional, Kang, K., additional, Kim, B., additional, Kwon, O., additional, Kim, Y.W., additional, Lee, J.J., additional, Hwang, Y.H., additional, Kwon, H.S., additional, Koo, J., additional, Lee, K., additional, Kim, T., additional, Ahn, A., additional, Rha, J.H., additional, Park, H.K., additional, Yoon, C.W., additional, Chan, B., additional, Teoh, H.L., additional, Paliwal, P., additional, Wong, L.Y.J., additional, Chen, J.T., additional, De Silva, D.A., additional, Chang, H.M., additional, Fabiaña, N., additional, Marti, J., additional, Delgado, R., additional, Martínez, A., additional, Prats, L., additional, Camps, P., additional, Liou, C.W., additional, Tan, T.Y., additional, Liu, C.F., additional, Cheng, H.H., additional, Po, H.L., additional, Lin, Y.J., additional, Chou, C.L., additional, Lin, C.H., additional, Yen, C.C., additional, Chang, Y.T., additional, Hsu, Y.T., additional, Lee, J.D., additional, Lee, M., additional, Huang, Y.C., additional, Wu, C.Y., additional, Suwanwela, N.C., additional, Chutinet, A., additional, Likitjaroen, Y., additional, Roongpiboonsopit, D., additional, Charnwut, S., additional, Dyker, A., additional, Hossain, M., additional, Muddegowda, G.K., additional, Sanyal, R., additional, Roffe, C., additional, Natarajan, I., additional, Finney, K., additional, Sztriha, L., additional, Teo, J., additional, Chan, F.K., additional, Lim, J., additional, Chitando, B., additional, Clarke, B., additional, Patel, B., additional, Khan, U., additional, Ghatala, R., additional, Trippier, S., additional, Kalra, L., additional, Manawadu, D., additional, Sikondari, N., additional, Aeron-Thomas, J., additional, Sunman, W., additional, Wilkes, G., additional, Richardson, C., additional, Buch, A., additional, Jackson, B., additional, Halse, O., additional, Mashate, S., additional, Wilding, P., additional, Nguyen, V., additional, Qadiri, M.R., additional, Rashed, K., additional, Board, S., additional, Buckley, C., additional, Smith, C., additional, James, M., additional, Keenan, S., additional, Bouring, A., additional, England, T., additional, Donnelly, R., additional, Scott, J., additional, Maddula, M., additional, Beavan, J., additional, Perry, R., additional, Francia, N., additional, Watchhurst, C., additional, Banaras, A., additional, Ashton, A., additional, Mistri, A., additional, Musarrat, K., additional, Eveson, D., additional, Kallingal, J., additional, Perez, J., additional, Harrison, L., additional, Marsden, T., additional, Furnace, J., additional, Clarke, R., additional, Reid, J., additional, Warburton, E., additional, Macleod, M.J., additional, Mitchell, J., additional, Day, D., additional, Church, N., additional, Amis, E., additional, Price, C., additional, Rodgers, H., additional, Whiting, R., additional, Hussain, M., additional, Harvey, M., additional, Brown, S., additional, Foot, J., additional, Tryambake, D., additional, Broughton, D., additional, Bergin, A., additional, Annamalai, A., additional, Dixon, L., additional, Weir, N., additional, Blank, C., additional, Harkness, K., additional, Ali, A., additional, Richards, E., additional, Stocks, K., additional, Bruce, D.W., additional, Wani, M., additional, Anjum, T., additional, Krishnan, M., additional, Nguyen Huy, T., additional, Le Tuan, A. Truong, additional, Cam, L. Dam Thi, additional, Kim, T. Ngo Thi, additional, Nguyen, B. Pham, additional, Dat, A. Nguyen, additional, Van, C. Nguyen, additional, Duy, T. Mai, additional, Viet, P. Dao, additional, Tien, D. Nguyen, additional, Van, T. Vo, additional, Le Kim, K., additional, Ngoc, T. Bui, additional, Le Thanh, T. Tran, additional, Hoanh, S. Nguyen, additional, Phuoc, S. Pham, additional, Van, T. Tran, additional, Thi, B. Doan, additional, Thu, H. Nguyen Thi, additional, Duy, M. Nguyen, additional, and Van, D. Ngo, additional

Published
2019
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4. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Author

Bath, Philip M, primary, Woodhouse, Lisa J, additional, Appleton, Jason P, additional, Beridze, Maia, additional, Christensen, Hanne, additional, Dineen, Robert A, additional, Duley, Lelia, additional, England, Timothy J, additional, Flaherty, Katie, additional, Havard, Diane, additional, Heptinstall, Stan, additional, James, Marilyn, additional, Krishnan, Kailash, additional, Markus, Hugh S, additional, Montgomery, Alan A, additional, Pocock, Stuart J, additional, Randall, Marc, additional, Ranta, Annemarei, additional, Robinson, Thompson G, additional, Scutt, Polly, additional, Venables, Graham S, additional, Sprigg, Nikola, additional, Christensen, L M, additional, Bentsen, L, additional, Krarup Hansen, C, additional, Thomsen, T T, additional, Kruuse, C, additional, Jensen, H H, additional, Hansen, S S, additional, Petrovic, V, additional, Beridze, N, additional, Kakabadze, N, additional, Kherkheulidze, T, additional, Kakabadze, D, additional, Toidze, I, additional, Lobjanidze, N, additional, Akiashvili, N, additional, Tevdoradze, A, additional, Khizanishvili, N, additional, Tsanava, T, additional, Taylor, R, additional, Iniesta, I, additional, Kok, J, additional, Duignan, J, additional, Funnell, M, additional, Cariga, P, additional, Rodriguez, M, additional, Watson, I J, additional, Tennant, S, additional, Macleod, M, additional, Furnace, J, additional, Gow, H, additional, Irvine, J, additional, Joyson, A, additional, Nelson, S, additional, Taylor, V, additional, Smith, M, additional, Bellfield, R, additional, Hairsine, B, additional, Davies, R, additional, Dodd, A, additional, Corrigan, J, additional, Doherty, M, additional, Ahmed, A, additional, Denniss, C, additional, Johnson-Holland, S, additional, Kay, K A, additional, Palau, R Icart, additional, Auld, G, additional, Daboo, P, additional, Erande, R, additional, Grimwood, G, additional, Hove, D, additional, Howaniec, L, additional, Redjep, O, additional, Rangasamay, R, additional, Butt, G, additional, Sandler, D, additional, Reddan, J, additional, Stafford, S, additional, McIlmoyle, J, additional, Maguire, S, additional, Murphy, P, additional, Chambers, J, additional, Guthrie, L, additional, Osborn, M, additional, Steele, A, additional, Burn, M, additional, Benford, A, additional, Misra, A, additional, Hilton, D, additional, O'Brien, E, additional, Amis, E, additional, Finlay, S, additional, Mitchell, J, additional, Geraghty, O, additional, Harvey, K, additional, Hazel, B, additional, Mashate, S, additional, Wilding, P, additional, Sajid, M, additional, Ball, M, additional, Gascoyne, R, additional, Sivakumar, R, additional, Wright, A, additional, Chatterjee, K, additional, Booth, S, additional, Eccleson, H, additional, Kelly, C, additional, Leason, S, additional, Perkins, C, additional, Bruce, D, additional, Brown, E, additional, Clayton, S, additional, Garside, M, additional, Rogers, G, additional, Lawrence, E, additional, Mahmood, S, additional, Watchurst, C, additional, Chadha, D, additional, Glover, L, additional, Holford, L, additional, Smith, K, additional, Walstow, D, additional, Williams, R, additional, O'Shea, L, additional, Goodsell, J, additional, Athulathmudali, C, additional, Barbon, E, additional, Namushi, R, additional, Jacob, P, additional, Johnson, L, additional, Morse, D, additional, McGhee, C, additional, Speirs, O, additional, Atkinson, S, additional, Peacocke, A, additional, Langhorne, P, additional, Graham, R, additional, Wright, F, additional, McAlpine, C, additional, Ravindrane, A, additional, Bajoriene, M, additional, Matter, L, additional, Windebank, S, additional, Giallombardo, E, additional, Dellafera, D, additional, Eglinton, C, additional, Wilson, J, additional, Broughton, D, additional, Chapman, K, additional, Dixon, L, additional, Zaidi, M, additional, Ayes, K, additional, Kessell, J, additional, Manawadu, D, additional, Adegbaju, O, additional, Aeron-Thomas, J, additional, Anderson, K, additional, Brigden, A, additional, Cattermole, E, additional, Good, J, additional, Hassan, S, additional, Khoromana, E, additional, Lee-Carbon, L, additional, Marks, K, additional, Mckenzie, E, additional, Sikondari, N, additional, Cooper, M, additional, Whysall, K, additional, Wynter, I, additional, Bamford, J, additional, Hassan, A, additional, Wanklyn, P, additional, Kambafwile, M, additional, Makawa, L, additional, Waugh, D, additional, Veraque, E, additional, Soliman, MGG, additional, Arif, S, additional, Brown, R, additional, Butler, S, additional, Hewitt, C, additional, Hindle, J, additional, Pusalkar, A, additional, Beadle, H, additional, Chan, K, additional, Siddiqui, M, additional, Dangri, P, additional, Buddha, S, additional, Asokanathan, A, additional, Mistri, A, additional, Eveson, D, additional, Musarrat, K, additional, Manning, L, additional, Anand, S, additional, Christian, P, additional, Khan, S, additional, Patel, C, additional, Sein, M, additional, Banns, J, additional, Gibson, E, additional, Gordon, T, additional, Gruenbeck, Y, additional, Wong, S, additional, Datta, P, additional, Bateman, G, additional, Jackson, L, additional, Needle, A, additional, Duodu, Y, additional, Oliver, R, additional, Padilla-Harris, C, additional, Barber, M, additional, Esson, D, additional, Brodie, F, additional, McInnes, C, additional, Fotherby, K, additional, Butler, D, additional, Morgan, D, additional, Preece, K, additional, Willberry, A, additional, Dent, M, additional, Hammonds, F, additional, Hunt, J, additional, Vernon, C, additional, O'Kane, D, additional, Faola, F, additional, Lai, P, additional, O'Callaghan, J, additional, Smith, C, additional, Price, C, additional, Lakey, R, additional, Riddell, V, additional, Smith, A, additional, Storey, G, additional, Munshi, S, additional, Buck, A, additional, Clarke, J, additional, Gilzeane, N, additional, Godfrey, M, additional, Keshvara, R, additional, Richardson, C, additional, Roffe, J, additional, Ryan, L, additional, Shelton, F, additional, Sunman, W, additional, Tittle, A, additional, Tomlinson, J, additional, Whittamore, K, additional, Wilkes, G, additional, Owusu-Agyei, P, additional, Temple, N, additional, Mangion, D, additional, Hardwick, A, additional, Netherton, K, additional, Nor, A Mohd, additional, Hyams, B, additional, Norman, S, additional, Persad, N, additional, Ragab, S, additional, Dickson, C, additional, Dube, J, additional, Jinks, E, additional, Knops, K, additional, Wadams, B, additional, Ali, K, additional, Gaylard, J, additional, Spurling, G, additional, Sztriha, L, additional, Ajao, T, additional, Alao, M, additional, Chan, F K, additional, Webster, P, additional, Howard, P, additional, Dobson, T J, additional, Hyatt, L, additional, Sims, D, additional, Cunningham, J, additional, Esisi, B, additional, Cassidy, T, additional, Bokhari, M, additional, McClelland, B, additional, Mokoena, B, additional, Gunathilagan, G, additional, Jones, S, additional, Reader, M, additional, Thomas, G, additional, Tilby, S, additional, Findlay, P, additional, Barrett, F, additional, Leslie, F, additional, Ross, S, additional, Shread, I, additional, Okwera, J, additional, Howe, J, additional, Harrington, F, additional, Courtauld, G, additional, Schofield, C, additional, Donnelly, R, additional, Maddula, M, additional, Scott, J, additional, Beavan, J, additional, Muhidden, K, additional, Memon, I, additional, Clarke, M, additional, Hedstrom, A, additional, Mills, L, additional, Hemsley, A, additional, Bowring, A, additional, Boxall, L, additional, Kingwell, H, additional, Keenan, S, additional, Roughan, C, additional, Manoj, A, additional, Cox, P, additional, Fletcher, G, additional, Lopez, P, additional, Emsley, H, additional, Gregary, B, additional, McLoughlin, A, additional, Raj, S, additional, Roffe, C, additional, Abano, N, additional, Barry, A, additional, Butler, A, additional, Carpio, R, additional, Castro, K, additional, Finney, K, additional, Gomm, S, additional, Hiden, J, additional, Grocott, J, additional, Lyjko, S, additional, Maguire, H, additional, Remegoso, A, additional, Sanyal, R, additional, Stevens, S, additional, Natarajan, I, additional, Chembala, J, additional, Muddegowda, G, additional, Warusevitane, A, additional, Blight, A, additional, Balazikova, O, additional, Lawlor, C, additional, Shaw, L, additional, Button, D, additional, Howcroft, D, additional, Lucas, S, additional, Madigan, B, additional, McCann, S, additional, Dixit, A, additional, Barkat, A, additional, Davis, J, additional, Fawcett, M, additional, Finlay, L, additional, Guy, H, additional, Hays, C, additional, Hogg, V, additional, Horsley, E, additional, Hubbuck, C, additional, Pringle, C, additional, Stevenson, C, additional, Storey, K, additional, Thompson, T, additional, Woodward, S, additional, Banerjee, A, additional, Allcock, C, additional, Merotra, S, additional, Douglass, C, additional, Campbell, E, additional, Jarapa, R, additional, Johnes, M, additional, Keaveney, C, additional, Marsden, T, additional, Naing, Z, additional, Perez, J, additional, Shaw, K, additional, Black, T, additional, Anthony, A, additional, Clarke, C, additional, Paterson, J, additional, Deighton, K, additional, Temlett, E, additional, Blank, C, additional, Doyle, C, additional, Duty, S, additional, Gill, K, additional, Harkness, K, additional, Kamara, C, additional, Richards, E, additional, Elfandi, K, additional, Guyler, P, additional, Harman, P, additional, Khuoge, C, additional, Kunhunny, S, additional, Tysoe, S, additional, Moynihan, B, additional, Adedoyin, T, additional, Chopra, N, additional, Dayal, N, additional, Ghatala, R, additional, Jeyaraj, N, additional, Jones, I, additional, Kennedy, F, additional, Kerin, L, additional, Khanom, N, additional, Lewis, S, additional, Maheswaran, S, additional, Montague, L, additional, Niemierko, M, additional, O'Reilly, J, additional, Trippier, S, additional, Watson, F, additional, Wilkinson, P, additional, Young, E, additional, Dizayee, K, additional, Cochrane, H, additional, O'Connell, J, additional, Mokoena, L, additional, Osborne, E, additional, Nair, A, additional, Greig, J, additional, Jenkins, C, additional, Powell, J, additional, Price, F, additional, Chowdhury, M, additional, Brixey, S, additional, Hunt, L, additional, Rands, N, additional, Rose, G, additional, Stoddart, S, additional, Srinivasan, M, additional, Motherwell, N, additional, Shekhar, R, additional, Fuller, T, additional, Lankester, A, additional, Lingwood, P, additional, Rankin, C, additional, Webb, H, additional, Jupp, B, additional, Bell, J, additional, Hann, G, additional, Longland, B, additional, Ovington, C, additional, Bhaskaran, B, additional, Ayres, G, additional, Bailey, C, additional, Bearne, H, additional, Buxton, J, additional, Fitzell, P, additional, Hilaire, C, additional, Kelly, D, additional, Szabo, S, additional, Tomlin, D, additional, Gamble, E, additional, Charles, B, additional, Kumar, R, additional, Fluskey, T, additional, Mellor, Z, additional, Peters, J, additional, Sutton, V, additional, Kenton, A, additional, Martin, I, additional, Nyabadza, S, additional, Ghosh, S, additional, Henry, M, additional, Kumar, B, additional, Ambulo, C, additional, Crawford, S, additional, Nozedar, T, additional, Platton, M, additional, Cvoro, V, additional, Couser, M, additional, McCormick, K, additional, Wilkinson, D, additional, Javaid, K, additional, Hurdowar, S, additional, Attygalle, T, additional, Sundayi, S, additional, Orugun, O, additional, Crowther, H, additional, Jolly, R, additional, Poultney, U, additional, Azim, A, additional, Krasinska-Chavez, M, additional, White, J, additional, Sengupta, N, additional, Margalef, J, additional, Metiu, M G, additional, Meenakshisundaram, S, additional, Dealing, S, additional, Hargroves, D, additional, Beranova, E, additional, Cowie, L, additional, Rudenko, H, additional, Thomson, A, additional, Verrion, A, additional, Rashed, K, additional, Board, S, additional, Buckley, C, additional, Hayward, D, additional, Jenkins, K, additional, Keeling, E, additional, Rowland-Axe, R, additional, Vickers, C, additional, Wood, D, additional, Lehman, A, additional, Patel, M, additional, Russell, H, additional, Rehman, H, additional, Forrest, D, additional, and Farren, P, additional

Published
2018
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5. The provenancing of flint artefacts using palynological techniques

Author

Harding, I.C., Trippier, S., Steele, J., Walker, E.A., Wenban-Smith, F., and Healy, F.

Abstract

The provenancing of flint artefacts has proved problematic in the past. Acid maceration to extract age-diagnostic organic-walled microplankton from sedimentary materials is a technique routinely employed in both industrial hydrocarbon exploration and Quaternary studies. Here we assess the application of this technique to provenance determination of flint nodules from three locations (two in southern England and one in the Inner Hebrides, Scotland), each of which has abundant local evidence of flint utilization for artefact manufacture in prehistory. We show that, whilst not all flint nodules yield abundant or well preserved organic-walled microfossils assemblages, there is a significant potential for the use of this technique, which deserves further investigation.

Published
2004

6. Testing the cognitive effects of tadalafil. Neuropsychological secondary outcomes from the PASTIS trial.

Author

Pauls MM, Fish J, Binnie LR, Benjamin P, Betteridge S, Clarke B, Dhillon MK, Ghatala R, Hainsworth FA, Howe FA, Khan U, Kruuse C, Madigan JB, Moynihan B, Patel B, Pereira AC, Rostrup E, Shtaya AB, Spilling CA, Trippier S, Williams R, Young R, Barrick TR, Isaacs JD, and Hainsworth AH

Abstract

Cerebral small vessel disease (SVD) is a major cause of cognitive impairment in older people. As secondary endpoints in a phase-2 randomised clinical trial, we tested the effects of single administration of a widely-used PDE5 inhibitor, tadalafil, on cognitive performance in older people with SVD. In a double-blinded, placebo-controlled, cross-over trial, participants received tadalafil (20 mg) and placebo on two visits ≥ 7 days apart (randomised to order of treatment). The Montreal Cognitive Assessment (MOCA) was administered at baseline, alongside a measure to estimate optimal intellectual ability (Test of Premorbid Function). Then, before and after treatment, a battery of neuropsychological tests was administered, assessing aspects of attention, information processing speed, working memory and executive function. Sixty-five participants were recruited and 55 completed the protocol ( N  = 55, age: 66.8 (8.6) years, range 52-87; 15/40 female/male). Median MOCA score was 26 (IQR: 23, 27], range 15-30). No significant treatment effects were seen in any of the neuropsychological tests. There was a trend towards improved performance on Digit Span Forward (treatment effect 0.37, C.I. 0.01, 0.72; P  = 0.0521). We did not identify significant treatment effects of single-administration tadalafil on neuropsychological performance in older people with SVD. The trend observed on Digit Span Forward may help to inform future studies., Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT00123456, https://eudract.ema.europa.eu. Unique identifier: 2015-001,235-20NCT00123456., Competing Interests: MMHP and LRB were employed as part of the PASTIS trial, JDI was Principal Investigator and AHH was Chief Investigator. CK is a PI on clinical trials funded by Bristol-Myers-Squibb and Bayer, and has received funding from NovoNordisk, all not relevant to the present trial. JDI has been a PI on clinical trials funded by Roche, Merck and Lupin Pharmaceuticals and has received funds from Nestle, Biogen and Roche, none relevant to the present trial. AHH leads MRC-Dementias Platform UK Vascular Experimental Medicine group. All other authors report no relevant disclosures. The trial was subject to an ICH-Good Clinical Practice (GCP) inspection by the UK medicines regulator, the MHRA, in September 2019, which identified a number of regulatory findings associated with the management of the trial. These are outlined in the supplementary information., (© 2023 The Authors.)

Published
2023
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7. Dissection-related tandem occlusion may be different from atherothrombotic tandem occlusion.

Author

Zhang L, Trippier S, Banerjee S, Xu T, Leyon J, Taylor E, Shtaya A, Sim CH, Gargalas S, Khan U, Cluckie G, Holt P, Lobotesis K, Clifton A, Markus HS, Goyal M, and Ogungbemi A

Subjects
Humans, Treatment Outcome, Carotid Artery, Internal diagnostic imaging, Thrombectomy adverse effects, Retrospective Studies, Stents, Stroke diagnostic imaging, Stroke etiology, Brain Ischemia complications, Endovascular Procedures adverse effects, Arterial Occlusive Diseases complications, Carotid Artery Diseases complications
Abstract

Objectives: The optimal endovascular treatment for tandem occlusion in anterior circulation ischaemic stroke remains unknown. The aim of this study was to examine how the aetiology of carotid pathology, dissection versus atherothrombosis, affects clinical outcomes., Materials and Methods: Data was obtained from prospectively collected registries from two stroke centres between April 2016 and December 2020. Tandem cases with complete cervical internal carotid artery (ICA) occlusion or near-total occlusion (≥90% stenosis) were included. Patients were divided into two groups based on carotid pathology: dissection versus atherothrombosis., Results: A total of 134 patients were included: 36 were dissection and 98 were atherothrombosis. The dissection group had better clinical outcomes compared to the atherothrombosis group, although after adjusting for age and stroke risk factors differences were non-significant. In the non-stented cohort, the dissection patients achieved a better outcome (modified Rankin scale 0-2) than atherothrombotic patients (57% vs. 34%, p=0.04) at 90-days., Conclusion: Dissection-related tandem occlusions appear to have different clinical features from atherothrombotic tandem occlusions which suggests different management strategies are needed., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Published
2023
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8. The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment.

Author

Pauls MMH, Binnie LR, Benjamin P, Betteridge S, Clarke B, Dhillon MK, Ghatala R, Hainsworth FAH, Howe FA, Khan U, Kruuse C, Madigan JB, Moynihan B, Patel B, Pereira AC, Rostrup E, Shtaya ABY, Spilling CA, Trippier S, Williams R, Young R, Barrick TR, Isaacs JD, and Hainsworth AH

Subjects
Humans, Aged, Tadalafil therapeutic use, Double-Blind Method, Cognitive Dysfunction drug therapy
Abstract

Introduction: There are few randomized clinical trials in vascular cognitive impairment (VCI). This trial tested the hypothesis that the PDE5 inhibitor tadalafil, a widely used vasodilator, increases cerebral blood flow (CBF) in older people with symptomatic small vessel disease, the main cause of VCI., Methods: In a double-blind, placebo-controlled, cross-over trial, participants received tadalafil (20 mg) and placebo on two visits ≥7 days apart (randomized to order of treatment). The primary endpoint, change in subcortical CBF, was measured by arterial spin labelling., Results: Tadalafil increased CBF non-significantly in all subcortical areas (N = 55, age: 66.8 (8.6) years) with greatest treatment effect within white matter hyperintensities (+9.8%, P = .0960). There were incidental treatment effects on systolic and diastolic blood pressure (-7.8, -4.9 mmHg; P < .001). No serious adverse events were observed., Discussion: This trial did not identify a significant treatment effect of single-administration tadalafil on subcortical CBF. To detect treatment effects may require different dosing regimens., (© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2022
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9. Test-retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease.

Author

Binnie LR, Pauls MMH, Benjamin P, Dhillon MK, Betteridge S, Clarke B, Ghatala R, Hainsworth FAH, Howe FA, Khan U, Kruuse C, Madigan JB, Moynihan B, Patel B, Pereira AC, Rostrup E, Shtaya ABY, Spilling CA, Trippier S, Williams R, Isaacs JD, Barrick TR, and Hainsworth AH

Subjects
Aged, Brain blood supply, Cerebrovascular Circulation physiology, Clinical Trials as Topic, Female, Humans, Magnetic Resonance Imaging methods, Male, Reproducibility of Results, Spin Labels, Leukoaraiosis, White Matter diagnostic imaging
Abstract

Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter.Here we quantified test-retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days).Test-retest reliability for CBF was high in all tissue types, with intra-class correlation coefficient [95%CI]: 0.758 [0.616, 0.852] for whole brain, 0.842 [0.743, 0.905] for total grey matter, 0.771 [0.636, 0.861] for deep grey matter (caudate-putamen and thalamus), 0.872 [0.790, 0.923] for normal-appearing white matter (NAWM) and 0.780 [0.650, 0.866] for WMH (all p<0.001). ANCOVA models indicated significant decline in CBF in total grey matter, deep grey matter and NAWM with increasing age and diastolic blood pressure (all p<0.001). CBF was lower in males relative to females (p=0.013 for total grey matter, p=0.004 for NAWM).We conclude that pCASL has high test-retest reliability as a quantitative measure of CBF in older adults with SVD. These findings support the use of pCASL in routine clinical imaging and as a clinical trial endpoint.All data come from the PASTIS trial, prospectively registered at: https://eudract.ema.europa.eu (2015-001235-20, registered 13/05/2015), http://www.clinicaltrials.gov (NCT02450253, registered 21/05/2015)., (© 2021. The Author(s).)

Published
2022
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10. Strokectomy for malignant middle cerebral artery infarction: experience and meta-analysis of current evidence.

Author

Moughal S, Trippier S, Al-Mousa A, Hainsworth AH, Pereira AC, Minhas PS, and Shtaya A

Subjects
Adult, Craniotomy, Decompression, Surgical, Humans, Infarction, Middle Cerebral Artery surgery, Middle Aged, Treatment Outcome, Decompressive Craniectomy, Stroke surgery
Abstract

Strokectomy means surgical excision of infarcted brain tissue post-stroke with preservation of skull integrity, distinguishing it from decompressive hemicraniectomy. Both can mitigate malignant middle cerebral artery (MCA) syndrome but evidence regarding strokectomy is sparse. Here, we report our data and meta-analysis of strokectomy compared to hemicraniectomy for malignant MCA infarction. All malignant MCA stroke cases requiring surgical intervention in a large tertiary centre (January 2012-December 2017, N = 24) were analysed for craniotomy diameter, complications, length of follow-up and outcome measured using the modified Rankin score (mRS). Good outcome was defined as mRS 0-3 at 12 months. In a meta-analysis, outcome from strokectomy (pooled from our cohort and published strokectomy studies) was compared with hemicraniectomy (our cohort pooled with published DECIMAL, DESTINY and HAMLET clinical trial data). In our series (N = 24, 12/12 F/M; mean age: 45.83 ± 8.91, range 29-63 years), 4 patients underwent strokectomy (SC) and 20 hemicraniectomy (HC). Among SC patients, craniotomy diameter was smaller, relative to HC patients (86 ± 13.10 mm, 120 ± 4.10 mm, respectively; p = 0.003), complications were less common (25%, 55%) and poor outcomes were less common (25%, 70%). In the pooled data (N = 41 SC, 71 HC), strokectomy tended towards good outcome more than hemicraniectomy (OR 2.2, 95% CI 0.99-4.7; p = 0.051). In conclusion, strokectomy may be non-inferior, lower risk and cost saving relative to hemicraniectomy sufficiently to be worthy of further investigation and maybe a randomised trial., (© 2020. The Author(s).)

Published
2022
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11. Innate Immune Anti-Inflammatory Response in Human Spontaneous Intracerebral Hemorrhage.

Author

Shtaya A, Bridges LR, Williams R, Trippier S, Zhang L, Pereira AC, Nicoll JAR, Boche D, and Hainsworth AH

Subjects
Adult, Aged, Aged, 80 and over, Cerebral Hemorrhage pathology, Female, Hemorrhagic Stroke pathology, Humans, Macrophages immunology, Male, Microglia immunology, Middle Aged, Neuroinflammatory Diseases pathology, Cerebral Hemorrhage immunology, Hemorrhagic Stroke immunology, Immunity, Innate immunology, Neuroinflammatory Diseases immunology
Abstract

Background and Purpose: Spontaneous intracerebral hemorrhage (sICH) is a common form of hemorrhagic stroke, with high mortality and morbidity. Pathophysiological mechanisms in sICH are poorly understood and treatments limited. Neuroinflammation driven by microglial-macrophage activation contributes to brain damage post-sICH. We aim to test the hypothesis that an anti-inflammatory (repair) process occurs in parallel with neuroinflammation in clinical sICH., Methods: We performed quantitative analysis of immunohistochemical markers for microglia and macrophages (Iba1, CD68, TMEM119, CD163, and CD206) in brain tissue biospecimens 1 to 12 days post-sICH and matched control cases. In a parallel, prospective group of patients, we assayed circulating inflammatory markers (CRP [C-reactive protein], total white cell, and monocyte count) over 1 to 12 days following sICH., Results: In 27 supratentorial sICH cases (n=27, median [interquartile range] age: 59 [52–80.5], 14F/13M) all microglia-macrophage markers increased post-sICH, relative to control brains. Anti-inflammatory markers (CD163 and CD206) were elevated alongside proinflammatory markers (CD68 and TMEM119). CD163 increased progressively post-sICH (15.0-fold increase at 7–12 days, P<0.001). CD206 increased at 3 to 5 days (5.2-fold, P<0.001) then returned to control levels at 7 to 12 days. The parenchymal immune response combined brain-derived microglia (TMEM119 positive) and invading monocyte-derived macrophages (CD206 positive). In a prospective sICH patient cohort (n=26, age 74 [66–79], National Institutes of Health Stroke Scale on admission: 8 [4–17]; 14F/12M) blood CRP concentration and monocyte density (but not white blood cell) increased post-sICH. CRP increased from 0 to 2 to 3 to 5 days (8.3-fold, P=0.020) then declined at 7 to 12 days. Monocytes increased from 0 to 2 to 3 to 5 days (1.8-fold, P<0.001) then declined at 7 to 12 days., Conclusions: An anti-inflammatory pathway, enlisting native microglia and blood monocytes, occurs alongside neuroinflammation post-sICH. This novel pathway offers therapeutic targets and a window of opportunity (3–5 days post-sICH) for delivery of therapeutics via invading monocytes.

Published
2021
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13. Hub-and-spoke model for thrombectomy service in UK NHS practice.

Author

Zhang L, Ogungbemi A, Trippier S, Clarke B, Khan U, Hall C, Ji Q, Clifton A, and Cluckie G

Subjects
England, Humans, State Medicine, Thrombectomy, Treatment Outcome, United Kingdom, Brain Ischemia, Stroke therapy
Abstract

Mechanical thrombectomy is a highly effective but time dependent treatment for acute ischaemic stroke due to large vessel occlusion. In the UK, the national clinical guidelines for stroke and National Institute for Health and Care Excellence guidance endorses thrombectomy as an acute stroke treatment, and NHS England commissioned thrombectomy services. However, there are no UK 'real-world' data to verify the efficacy of the hub-and-spoke model in thrombectomy. There are currently 24 tertiary neuroscience centres in the UK that can provide thrombectomy treatment and many of these operate only within working hours. This study is the first to demonstrate that a hub-and-spoke thrombectomy service in routine UK 24/7 clinical practice is as effective and safe as in the setting of randomised controlled clinical trials. However, there are 9.3% of patients accepted for transfer to the thrombectomy centre who did not proceed to thrombectomy, mostly due to delays. Fifty-three per cent of thrombectomy cases were performed outside of standard working hours when transfer delays were increased. A 24/7 thrombectomy service is needed to maximise the benefit to all suitable patients. Measures, including improving workflow and optimising work forces, are needed to minimise the delays and continue to improve the service., (© Royal College of Physicians 2021. All rights reserved.)

Published
2021
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14. Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease.

Author

Benjamin P, Trippier S, Lawrence AJ, Lambert C, Zeestraten E, Williams OA, Patel B, Morris RG, Barrick TR, MacKinnon AD, and Markus HS

Subjects
Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction etiology, Cognitive Dysfunction physiopathology, Magnetic Resonance Imaging, Multimodal Imaging, Stroke, Lacunar complications, Stroke, Lacunar diagnostic imaging, Stroke, Lacunar physiopathology
Abstract

Background and Purpose: Cerebral small-vessel disease is a major cause of cognitive impairment. Perivascular spaces (PvS) occur in small-vessel disease, but their relationship to cognitive impairment remains uncertain. One reason may be difficulty in distinguishing between lacunes and PvS. We determined the relationship between baseline PvS score and PvS volume with change in cognition over a 5-year follow-up. We compared this to the relationship between baseline lacune count and total lacune volume with cognition. In addition, we examined change in PvS volume over time., Methods: Data from the prospective SCANS study (St Georges Cognition and Neuroimaging in Stroke) of patients with symptomatic lacunar stroke and confluent leukoaraiosis were used (n=121). Multimodal magnetic resonance imaging was performed annually for 3 years and neuropsychological testing annually for 5 years. Lacunes were manually identified and distinguished from PvS. PvS were rated using a validated visual rating scale, and PvS volumes calculated using T1-weighted images. Linear mixed-effect models were used to determine the impact of PvS and lacunes on cognition., Results: Baseline PvS scores or volumes showed no association with cognitive indices. No change was detectable in PvS volumes over the 3 years. In contrast, baseline lacunes associated with all cognitive indices and predicted cognitive decline over the 5-year follow-up., Conclusions: Although a feature of small-vessel disease, PvS are not a predictor of cognitive decline, in contrast to lacunes. This study highlights the importance of carefully differentiating between lacunes and PvS in studies investigating vascular cognitive impairment., (© 2018 The Authors.)

Published
2018
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15. Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial.

Author

Pauls MMH, Clarke N, Trippier S, Betteridge S, Howe FA, Khan U, Kruuse C, Madigan JB, Moynihan B, Pereira AC, Rolfe D, Rostrup E, Haig CE, Barrick TR, Isaacs JD, and Hainsworth AH

Subjects
Administration, Oral, Cerebral Small Vessel Diseases diagnosis, Cerebral Small Vessel Diseases physiopathology, Cerebral Small Vessel Diseases psychology, Clinical Protocols, Cognition drug effects, Cross-Over Studies, Double-Blind Method, Humans, London, Neuropsychological Tests, Predictive Value of Tests, Sample Size, Time Factors, Treatment Outcome, Cerebral Small Vessel Diseases drug therapy, Cerebrovascular Circulation drug effects, Magnetic Resonance Imaging, Perfusion Imaging methods, Phosphodiesterase 5 Inhibitors administration & dosage, Spin Labels, Tadalafil administration & dosage, Vasodilator Agents administration & dosage
Abstract

Background: Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor that increases blood flow in other vascular territories. The aim of this trial is to test the hypothesis that tadalafil increases cerebral blood flow in older people with small vessel disease., Methods/design: Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS) is a phase II randomised double-blind crossover trial. In two visits, 7-30 days apart, participants undergo arterial spin labelling to measure cerebral blood flow and a battery of cognitive tests, pre- and post-dosing with oral tadalafil (20 mg) or placebo., Sample Size: 54 participants are required to detect a 15% increase in cerebral blood flow in subcortical white matter (p < 0.05, 90% power). Primary outcomes are cerebral blood flow in subcortical white matter and deep grey nuclei. Secondary outcomes are cortical grey matter cerebral blood flow and performance on cognitive tests (reaction time, information processing speed, digit span forwards and backwards, semantic fluency)., Discussion: Recruitment started on 4th September 2015 and 36 participants have completed to date (19th April 2017). No serious adverse events have occurred. All participants have been recruited from one centre, St George's University Hospitals NHS Foundation Trust., Trial Registration: European Union Clinical Trials Register: EudraCT number 2015-001235-20 . Registered on 13 May 2015.

Published
2017
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16. Right hemisphere control of visuospatial attention in near space.

Author

Longo MR, Trippier S, Vagnoni E, and Lourenco SF

Subjects
Adult, Brain Mapping, Color Perception Tests, Electroencephalography, Evoked Potentials physiology, Female, Humans, Judgment, Male, Photic Stimulation, Regression Analysis, Time Factors, Young Adult, Attention physiology, Functional Laterality physiology, Personal Space, Space Perception physiology
Abstract

Traditionally, the right cerebral hemisphere has been considered to be specialized for spatial attention and orienting. A large body of research has demonstrated dissociable representations of the near space immediately surrounding the body and the more distance far space. In this study, we investigated whether right hemisphere activations commonly reported for tasks involving spatial attention (such as the line bisection and landmark tasks) are specific to stimuli presented in near space. In separate blocks of trials, participants judged either whether a vertical transector was to the left or right of the centre of a line (landmark task) or whether the line was red or blue (colour task). Stimuli were seen from four distances (30, 60, 90, 120 cm). We used EEG to measure an ERP component (the 'line-bisection effect') specific to the direction of spatial attention (i.e., landmark minus colour). Consistent with previous results, spatial attention produced a right-lateralized negativity over occipito-parietal channels. The magnitude of this negativity was inversely related to viewing distance, being largest in near space and reduced in far space. These results suggest that the right occipito-temporal cortex may be specialized not just for the orientation of spatial attention generally, but specifically for orienting attention in the near space immediately surrounding the body., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Published
2015
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