219 results on '"Tripoli, Giada"'
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2. Lifestyles and Quality of Life of People with Mental Illness During the COVID-19 Pandemic
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Tripoli, Giada, Lo Duca, Sofia, Ferraro, Laura, Zahid, Uzma, Mineo, Raffaella, Seminerio, Fabio, Bruno, Alessandra, Di Giorgio, Vanessa, Maniaci, Giuseppe, Marrazzo, Giovanna, Sartorio, Crocettarachele, Scaglione, Alessandra, La Barbera, Daniele, and La Cascia, Caterina
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- 2024
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3. The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
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Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, Jose Luis, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, and Fisher, Helen L.
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- 2023
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4. Psychological distress and suicidal ideation in Sicilian Medical Students: The SMS-ME project
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Bonaccorso, Nicole, Tripoli, Giada, Vella, Ilaria, La Cascia, Caterina, Amodio, Emanuele, Bongiorno, Eleonora, Genovese, Dario, Maniaci, Giuseppe, Sciortino, Martina, Galatà, Elisa, Iacono, Giorgia, Romano, Alessandra, Guglielmino, Damiano, Seminerio, Fabio, Sartorio, Crocettarachele, Scaglione, Alessandra, Silvestri, Maria Catena, Baido, Rosa Lo, Quattropani, Maria Catena, Muscatello, Maria Rosaria Anna, Mento, Carmela, Signorelli, Maria Salvina, Quattrone, Diego, Vitale, Francesco, La Barbera, Daniele, Costantino, Claudio, and Ferraro, Laura
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- 2024
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5. The association of jumping to conclusions and facial emotion recognition with genetic liability and outcome of psychosis
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Tripoli, Giada, Murray, Robin MacGregor, and Morgan, Craig
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616.89 - Abstract
Introduction: Schizophrenia and other psychotic disorders are complex disorders with multifactorial aetiology encompassing genetic and environmental factors. The genetic architecture of these disorders involves many numerous loci implicated in conferring risk for developing the illness. Cognitive impairments are considered as important core features, serving as potential intermediate phenotypes for psychotic disorders. Cognitive biases including jumping to conclusions (JTC) and social cognition impairments such as difficulties in facial emotion recognition (FER) have been reported to be associated with psychosis, yet their link to shared genetic pathways with the disorder, and their contribution to psychotic outcome are still open questions. My thesis aimed to clarify the relation of these two biases with psychosis liability and with outcome. Methods: Data used in this Thesis come from two large-scale studies in which I participated: the multisite incidence and case-control EU-GEI study, and the Biological Phenotypes, Environment, Genes and Psychosis Outcome (GAP follow-up) study. To examine the presence of the JTC bias at first episode psychosis (FEP), taking into account the influence of general cognitive ability, I conducted a mediation analysis between case/control status, JTC, and IQ in a large sample of patients experiencing their FEP, and population controls. I then explored the associations of JTC with both psychosis and general cognition liability, estimating multiple linear regression models using calculated polygenic risk scores for schizophrenia (SZ PRS) and IQ (IQ PRS). Global and specific facial emotion recognition was analysed through fixed and random effects in repeated measures mixed models in the same large sample. Multiple linear regression models were used to investigate the association with FER and SZ PRS. In a London subsample in which I contributed to recruitment and assessment, I then tested both JTC and FER measured at FEP for multi-domain outcome prediction at, on average, 5-year-follow-up, based on estimated linear, ordinal, and multinomial logistic regression models. Finally, to test the stability of jumping to conclusions and facial emotion recognition over the years, intra-class correlations and repeated measures mixed models were performed. Results: The association between JTC and psychosis was shown to be fully mediated by IQ, and JTC was explained by the genetic underpinnings of IQ but not SZ PRS. Psychotic patients were more prone to display deficits in facial emotion recognition than controls, specifically in fear and anger recognition compared to happy or neutral faces. SZ PRS was associated with worse global facial emotion recognition and specifically with impairments in anger recognition. Neither JTC nor FER measured at FEP predicted any outcome domains at follow-up, although JTC showed a small effect on social outcome. Finally, an overall steady pattern of performance over time was detected for JTC and general facial emotion recognition in both patients and controls, with patients making hastier decisions and recognising fewer emotional faces than controls. Conclusions: My thesis contributed to clarifying the association of jumping to conclusions with psychotic disorders as mediated by general cognition; furthermore, JTC appeared not directly associated with common genetic risk variants for the disorder. However, this finding raised also the necessity of improved assessment for the JTC bias to reduce cognitive noise. On the other hand, findings on facial emotion recognition provided more evidence regarding impairment in global and emotion-specific recognition of emotional faces in the context of psychosis, corroborating previous findings from family studies; the results I obtained with polygenic risk score analysis suggested that facial emotion recognition - specifically negative emotions - could serve as intermediate phenotype for psychosis.
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- 2021
6. The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study
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Brink, Vera, primary, Andleeb, Humma, additional, Gayer-Anderson, Charlotte, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Berardi, Domenico, additional, Bernardo, Miquel, additional, Bobes, Julio, additional, Del-Ben, Cristina Marta, additional, Ferraro, Laura, additional, de Haan, Lieuwe, additional, La Barbera, Daniele, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Llorca, Pierre-Michel, additional, Menezes, Paolo Rossi, additional, Pignon, Baptiste, additional, Sanjuán, Julio, additional, Santos, José Luis, additional, Selten, Jean-Paul, additional, Tarricone, Ilaria, additional, Tortelli, Andrea, additional, Tripoli, Giada, additional, Velthorst, Eva, additional, Rutten, Bart P F, additional, van Os, Jim, additional, Quattrone, Diego, additional, Murray, Robin M, additional, Jones, Peter B, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Jongsma, Hannah E, additional, and Kirkbride, James B, additional
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- 2024
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7. Metabolic Syndrome in people treated with Antipsychotics (RISKMet): A multimethod study protocol investigating genetic, behavioural, and environmental risk factors
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de Girolamo, Giovanni, primary, La Cascia, Caterina, additional, Macchia, Paolo Emidio, additional, Nobile, Maria, additional, Calza, Stefano, additional, Camillo, Laura, additional, Mauri, Maddalena, additional, Pozzi, Marco, additional, Tripoli, Giada, additional, Vetrani, Claudia, additional, Caselani, Elisa, additional, and Magno, Marta, additional
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- 2024
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8. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study
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Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., and Quattrone, Diego
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- 2021
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9. The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study
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Hersenen-Medisch 1, Brain, Brink, Vera, Andleeb, Humma, Gayer-Anderson, Charlotte, Arango, Celso, Arrojo, Manuel, Berardi, Domenico, Bernardo, Miquel, Bobes, Julio, Del-Ben, Cristina Marta, Ferraro, Laura, de Haan, Lieuwe, La Barbera, Daniele, La Cascia, Caterina, Lasalvia, Antonio, Llorca, Pierre-Michel, Menezes, Paolo Rossi, Pignon, Baptiste, Sanjuán, Julio, Santos, José Luis, Selten, Jean-Paul, Tarricone, Ilaria, Tortelli, Andrea, Tripoli, Giada, Velthorst, Eva, Rutten, Bart P F, van Os, Jim, Quattrone, Diego, Murray, Robin M, Jones, Peter B, Morgan, Craig, Di Forti, Marta, Jongsma, Hannah E, Kirkbride, James B, Hersenen-Medisch 1, Brain, Brink, Vera, Andleeb, Humma, Gayer-Anderson, Charlotte, Arango, Celso, Arrojo, Manuel, Berardi, Domenico, Bernardo, Miquel, Bobes, Julio, Del-Ben, Cristina Marta, Ferraro, Laura, de Haan, Lieuwe, La Barbera, Daniele, La Cascia, Caterina, Lasalvia, Antonio, Llorca, Pierre-Michel, Menezes, Paolo Rossi, Pignon, Baptiste, Sanjuán, Julio, Santos, José Luis, Selten, Jean-Paul, Tarricone, Ilaria, Tortelli, Andrea, Tripoli, Giada, Velthorst, Eva, Rutten, Bart P F, van Os, Jim, Quattrone, Diego, Murray, Robin M, Jones, Peter B, Morgan, Craig, Di Forti, Marta, Jongsma, Hannah E, and Kirkbride, James B
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- 2024
10. The effect of polygenic risk score and childhood adversity experiences on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis
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Alameda, Luis, primary, Pérez, Victoria, additional, Forti, Marta di, additional, Spinazzola, Edoardo, additional, Trotta, Giulia, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bernardo, Miguel, additional, Bobes, Julio, additional, Gayer-Anderson, Charlotte, additional, Del-Ben, Cristina Marta, additional, Sideli, Lucia, additional, Jones, Peter, additional, Kirkbride, James, additional, Cascia, Caterina La, additional, Tripoli, Giada, additional, Ferraro, Laura, additional, Barbera, Daniele La, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Llorca, Pierre Michel, additional, Menezes, Paulo, additional, Os, Jim van, additional, Rutten, Bart, additional, Santos, Jose, additional, Sanjuan, Julio, additional, Selten, Jean-Paul, additional, Szöke, Andrei, additional, Tarricone, Ilaria, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, Johgsma, Hannah E., additional, Vassos, Evangelos, additional, Quattrone, Diego, additional, Murray, Robin, additional, and Aas, Monica, additional
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- 2024
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11. Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study
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D'Andrea, Giuseppe, primary, Quattrone, Diego, additional, Malone, Kathryn, additional, Tripoli, Giada, additional, Trotta, Giulia, additional, Spinazzola, Edoardo, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E, additional, Sideli, Lucia, additional, Stilo, Simona A, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Rossi Menezes, Paulo, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Sanjuán, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James B, additional, Jones, Peter B, additional, Rutten, Bart P, additional, Van Os, Jim, additional, Selten, Jean-Paul, additional, Vassos, Evangelos, additional, Schürhoff, Franck, additional, Szöke, Andrei, additional, Pignon, Baptiste, additional, O'Donovan, Michael, additional, Richards, Alexander, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Tarricone, Ilaria, additional, and Murray, Robin M, additional
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- 2024
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12. IQ differences between patients with first episode psychosis in London and Palermo reflect differences in patterns of cannabis use
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Ferraro, Laura, Murray, Robin M., Di Forti, Marta, Quattrone, Diego, Tripoli, Giada, Sideli, Lucia, La Barbera, Daniele, and La Cascia, Caterina
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- 2019
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13. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study
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Amoretti, Silvia, Arrojo, Manuel, Baudin, Grégoire, Beards, Stephanie, Bernardo, Miquel, Bobes, Julio, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Díaz-Caneja, Covadonga M, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, García Bernardo, Enrique, Garcia-Portilla, Paz, González, Emiliano, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Leboyer, Marion, López Montoya, Gonzalo, Lorente-Rovira, Esther, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Martínez, Covadonga, Matteis, Mario, Messchaart, Elles, Moltó, Ma Dolores, Nacher, Juan, Olmeda, Ma Soledad, Parellada, Mara, González Peñas, Javier, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rodríguez Solano, José Juan, Roldán Díaz, Laura, Ruggeri, Mirella, Sáiz, Pilar A., Sánchez, Emilio, Sanjuán, Julio, Sartorio, Crocettarachele, Schürhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Sideli, Lucia, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, van der Ven, Elsje, Di Forti, Marta, Quattrone, Diego, Freeman, Tom P, Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, Rutten, Bart PF, de Haan, Lieuwe, Sham, Pak C, van Os, Jim, Lewis, Cathryn M, Lynskey, Michael, Morgan, Craig, and Murray, Robin M
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- 2019
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14. The Relationship Between Dissociative Experiences and Cannabis Use: a Systematic Review
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Sideli, Lucia, Di Forti, Marta, Ferraro, Laura, Montana, Simonetta, Tripoli, Giada, Quattrone, Diego, Colizzi, Marco, La Barbera, Daniele, and La Cascia, Caterina
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- 2019
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15. Methylomic signature of current cannabis use in two first-episode psychosis cohorts
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Dempster, Emma, primary, Wong, Chloe, additional, Burrage, Joe, additional, Hannon, Eilis, additional, Quattrone, Diego, additional, Giulia, Trotta, additional, Rodriguez, Victoria, additional, Spinazzola, Edoardo, additional, Tripoli, Giada, additional, Austin-Zimmerman, Isabelle, additional, Li, Z, additional, Gayer-Anderson, Charlotte, additional, Freeman, Tom, additional, Johnson, Emma, additional, Jongsma, Hannah, additional, Simona, Stilo, additional, Cascia, Caterina La, additional, Ferraro, Laura, additional, Barbera, Daniele La, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tarricone, Ilaria, additional, D’Andrea, Giuseppe, additional, Galatolo, Michela, additional, Tortelli, Andrea, additional, Arango, Celso, additional, Jones, Peter, additional, Pompili, Maurizio, additional, Selten, Jean-Paul, additional, de Haan, Lieuwe, additional, Menezes, Paulo, additional, Del-Ben, Cristina Marta, additional, Santos, José, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Sanjuan, Julio, additional, Bernardo, Miquel, additional, Breen, Gerome, additional, Mondelli, Valeria, additional, Dazzan, Paola, additional, Iyegbe, Conrad, additional, Vassos, Evangelos, additional, Morgan, Craig, additional, Mukherjee, Diptendu, additional, Os, Jim van, additional, Rutten, Bart, additional, O'Donovan, Michael, additional, Sham, Pak, additional, Mill, Jonathan, additional, Murray, Robin, additional, Forti, Marta di, additional, and Alameda, Luis, additional
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- 2023
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16. IL RICONOSCIMENTO DELLE EMOZIONI FACCIALI NEI DISTURBI PSICOTICI: UNO STUDIO SUI MECCANISMI GENETICI ED EPIGENETICI
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TRIPOLI, Giada, LA BARBERA, Daniele, and TUTTOLOMONDO, Antonino
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facial emotion recognition ,polygenic risk ,DNA methylation ,psychosis - Abstract
La schizofrenia e altri disturbi psicotici sono disturbi complessi con eziologia multifattoriale che comprende fattori genetici e ambientali. L’architettura genetica di questi disturbi coinvolge numerosi loci implicati nel conferire il rischio di sviluppare la malattia. Inoltre, gli studi che indagano l’eziologia molecolare di questi disturbi hanno mostrato un interesse crescente per le variazioni epigenetiche, specialmente la metilazione del DNA. I disturbi della social cognition, come le difficoltà nel riconoscimento delle emozioni facciali (FER), sono associati con i disturbi psicotici; tuttavia, il loro legame con la genetica e l’epigenetica di questi disturbi sono questioni ancora aperte. I dati utilizzati in questa tesi provengono da due studi: lo studio multicentrico di incidenza e casocontrollo EU-GEI e lo studio di follow-up Sicilian Genetics and Psychosis (SGAP follow-up). Il riconoscimento globale e specifico delle emozioni facciali è stato analizzato attraverso modelli mixed effect tra casi e controlli. Sono stati utilizzati modelli di regressione lineare multipla per studiare l’associazione del FER con il punteggio di rischio poligenico per la schizofrenia (SZ PRS) e, per la prima volta, con i profili di metilazione differenziale del DNA dell’intero genoma (Differentially Methylated Positions – DMPs). In un sottocampione di controlli reclutati a Palermo è stato condotto un follow up a 8 anni ed è stata analizzata la correlazione tra FER a baseline e il cambiamento della sintomatologia subclinica (esperienze simil-psicotiche e schizotipia). I pazienti psicotici presentavano più frequentemente deficit nel riconoscimento delle emozioni facciali rispetto ai controlli, in particolare nel riconoscimento della paura e della rabbia rispetto ai volti felici o neutri. Lo SZ PRS è stato associato a un peggiore riconoscimento globale delle emozioni facciali e in particolare nel riconoscimento della rabbia. Sono state identificate diverse DMPs associate al FER che, sebbene non raggiungessero la soglia di significatività epigenome-wide, erano localizzate in geni espressi a livello del sistema nervoso centrale e già replicati in altri studi di associazione epigenome-wide (EWAS) nella schizofrenia. Infine, compromissioni del riconoscimento delle emozioni negative correlavano con cambiamenti nella schizotipia e nei sintomi subclinici dopo otto anni in un campione della popolazione generale di Palermo. 5 L’analisi EWAS rappresenta una prima indagine esplorativa sul riconoscimento delle emozioni facciali che suggerisce ulteriori sviluppi per la ricerca epigenetica su questo dominio. I risultati sul FER rappresentano ulteriori evidenze riguardo alla compromissione del riconoscimento globale e specifico delle emozioni facciali nel contesto della psicosi, corroborando i precedenti risultati degli studi su familiari e suggerendo come il riconoscimento delle emozioni facciali - in particolare le emozioni negative - possa essere un fenotipo intermedio per la psicosi.
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- 2023
17. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study
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European Commission, South-Eastern Norway Regional Health Authority, Brain and Behavior Research Foundation, Aas, Monica [0000-0002-2338-5826], Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodríguez, Victoria, Vassos, Evangelos, Sham, Pak C., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, Haan, Lieuwe de, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P. F., Os, Jim van, Gayer-Anderson, Charlotte, Murray, Robin M., Morgan, Craig, European Commission, South-Eastern Norway Regional Health Authority, Brain and Behavior Research Foundation, Aas, Monica [0000-0002-2338-5826], Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodríguez, Victoria, Vassos, Evangelos, Sham, Pak C., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, Haan, Lieuwe de, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P. F., Os, Jim van, Gayer-Anderson, Charlotte, Murray, Robin M., and Morgan, Craig
- Abstract
[Background] A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone., [Methods] We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case–control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)exposure and PRS − ORexposure − ORPRS + 1] with adjustment for potential confounders., [Results] There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) −1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI −6.25 to 20.88)., [Conclusions] Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates.
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- 2023
18. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study
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Hersenen-Medisch 1, Brain, D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Stilo, Simona A, van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Murray, Robin M, di Forti, Marta, Tarricone, Ilaria, Morgan, Craig, Hersenen-Medisch 1, Brain, D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Stilo, Simona A, van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Murray, Robin M, di Forti, Marta, Tarricone, Ilaria, and Morgan, Craig
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- 2023
19. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study
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Hersenen-Medisch 1, Brain, Rodriguez, Victoria, Alameda, Luis, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Spinazzola, Edoardo, Trotta, Giulia, Jongsma, Hannah E, Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Bonora, Elena, Jamain, Stéphane, Selten, Jean-Paul, Velthorst, Eva, de Haan, Lieuwe, Llorca, Pierre-Michel, Arrojo, Manuel, Bobes, Julio, Bernardo, Miguel, Arango, Celso, Kirkbride, James, Jones, Peter B, Rutten, Bart P, Richards, Alexander, Sham, Pak C, O'Donovan, Michael, Van Os, Jim, Morgan, Craig, Di Forti, Marta, Murray, Robin M, Vassos, Evangelos, Hersenen-Medisch 1, Brain, Rodriguez, Victoria, Alameda, Luis, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Spinazzola, Edoardo, Trotta, Giulia, Jongsma, Hannah E, Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Bonora, Elena, Jamain, Stéphane, Selten, Jean-Paul, Velthorst, Eva, de Haan, Lieuwe, Llorca, Pierre-Michel, Arrojo, Manuel, Bobes, Julio, Bernardo, Miguel, Arango, Celso, Kirkbride, James, Jones, Peter B, Rutten, Bart P, Richards, Alexander, Sham, Pak C, O'Donovan, Michael, Van Os, Jim, Morgan, Craig, Di Forti, Marta, Murray, Robin M, and Vassos, Evangelos
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- 2023
20. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: The EU-GEI study
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Hersenen-Medisch 1, Brain, Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodriguez, Victoria, Vassos, Evangelos, Sham, Pak, Tripoli, Giada, Cascia, Caterina La, Barbera, Daniele La, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre Michel, Arango, Celso, Tortelli, Andrea, De Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P.F., Van Os, Jim, Gayer-Anderson, Charlotte, Murray, Robin M., Morgan, Craig, Hersenen-Medisch 1, Brain, Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodriguez, Victoria, Vassos, Evangelos, Sham, Pak, Tripoli, Giada, Cascia, Caterina La, Barbera, Daniele La, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre Michel, Arango, Celso, Tortelli, Andrea, De Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P.F., Van Os, Jim, Gayer-Anderson, Charlotte, Murray, Robin M., and Morgan, Craig
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- 2023
21. The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
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European Commission, Sao Paulo Research Foundation, Netherlands Organization for Scientific Research, Economic and Social Research Council (UK), Kings College London, Medical Research Council (UK), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Comunidad de Madrid, National Institute of Mental Health (US), Fundación Familia Alonso, Fundación Alicia Koplowitz, Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, EU-GEI WP2 Group, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, José Luis, Rossi Menezes, Paulo, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, Haan, Lieuwe de, Selten, Jean-Paul, Os, Jim van, Rutten, Bart P. F., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, Fisher, Helen L., European Commission, Sao Paulo Research Foundation, Netherlands Organization for Scientific Research, Economic and Social Research Council (UK), Kings College London, Medical Research Council (UK), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Comunidad de Madrid, National Institute of Mental Health (US), Fundación Familia Alonso, Fundación Alicia Koplowitz, Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, EU-GEI WP2 Group, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, José Luis, Rossi Menezes, Paulo, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, Haan, Lieuwe de, Selten, Jean-Paul, Os, Jim van, Rutten, Bart P. F., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, and Fisher, Helen L.
- Abstract
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
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- 2023
22. Methylomic signature of current cannabis use in two first-episode psychosis cohorts
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Dempster, Emma L., Wong, Chloe C. Y., Burrage, Joe, Hannon, Eilis, Quattrone, Diego, Trotta, Giulia, Rodriguez, Victoria, Alameda, Luis, Spinazzola, Edoardo, Tripoli, Giada, Austin-Zimmerman, Isabelle, Li, Zhikun, Gayer-Anderson, Charlotte, Freeman, Tom P., Johnson, Emma C., Jongsma, Hannah E., Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D’Andrea, Giuseppe, Galatolo, Michela, Tortelli, Andrea, Pompili, Maurizio, Selten, Jean-Paul, de Haan, Lieuwe, Menezes, Paulo Rossi, Del Ben, Cristina M., Santos, Jose Luis, Arrojo, Manuel, Bobes, Julio, Sanjuán, Julio, Bernardo, Miguel, Arango, Celso, Jones, Peter B., Breen, Gerome, Mondelli, Valeria, Dazzan, Paola, Iyegbe, Conrad, Vassos, Evangelos, Morgan, Craig, Mukherjee, Diptendu, van Os, Jim, Rutten, Bart, O’Donovan, Michael C., Sham, Pak, Mill, Jonathan, Murray, Robin, and Di Forti, Marta
- Abstract
The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gained increasing recognition as vital factors in the interplay between risk factors and mental health. This study aimed to explore the effects of current cannabis use and high-potency cannabis on DNA methylation in two independent cohorts of individuals experiencing first-episode psychosis (FEP) compared to control subjects. The combined sample consisted of 682 participants (188 current cannabis users and 494 never users). DNA methylation profiles were generated on blood-derived DNA samples using the Illumina DNA methylation array platform. A meta-analysis across cohorts identified one CpG site (cg11669285) in the CAVIN1gene that showed differential methylation with current cannabis use, surpassing the array-wide significance threshold, and independent of the tobacco-related epigenetic signature. Furthermore, a CpG site localised in the MCUgene (cg11669285) achieved array-wide significance in an analysis of the effect of high-potency (THC = > 10%) current cannabis use. Pathway and regional analyses identified cannabis-related epigenetic variation proximal to genes linked to immune and mitochondrial function, both of which are known to be influenced by cannabinoids. Interestingly, a model including an interaction term between cannabis use and FEP status identified two sites that were significantly associated with current cannabis use with a nominally significant interaction suggesting that FEP status might moderate how cannabis use affects DNA methylation. Overall, these findings contribute to our understanding of the epigenetic impact of current cannabis use and highlight potential molecular pathways affected by cannabis exposure.
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- 2024
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23. The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case–control study.
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Spinazzola, Edoardo, Quattrone, Diego, Rodriguez, Victoria, Trotta, Giulia, Alameda, Luis, Tripoli, Giada, Gayer-Anderson, Charlotte, Freeman, Tom P, Johnson, Emma C, Jongsma, Hannah E, Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Galatolo, Michela, and Tortelli, Andrea
- Subjects
CANNABIS (Genus) ,CONFIDENCE intervals ,PSYCHOSES ,CASE-control method ,RISK assessment ,AFFECTIVE disorders ,CHI-squared test ,DESCRIPTIVE statistics ,LOGISTIC regression analysis - Abstract
Background: While cannabis use is a well-established risk factor for psychosis, little is known about any association between reasons for first using cannabis (RFUC) and later patterns of use and risk of psychosis. Methods: We used data from 11 sites of the multicentre European Gene-Environment Interaction (EU-GEI) case–control study. 558 first-episode psychosis patients (FEPp) and 567 population controls who had used cannabis and reported their RFUC. We ran logistic regressions to examine whether RFUC were associated with first-episode psychosis (FEP) case–control status. Path analysis then examined the relationship between RFUC, subsequent patterns of cannabis use, and case–control status. Results: Controls (86.1%) and FEPp (75.63%) were most likely to report 'because of friends' as their most common RFUC. However, 20.1% of FEPp compared to 5.8% of controls reported: 'to feel better' as their RFUC (χ
2 = 50.97; p < 0.001). RFUC 'to feel better' was associated with being a FEPp (OR 1.74; 95% CI 1.03–2.95) while RFUC 'with friends' was associated with being a control (OR 0.56; 95% CI 0.37–0.83). The path model indicated an association between RFUC 'to feel better' with heavy cannabis use and with FEPp-control status. Conclusions: Both FEPp and controls usually started using cannabis with their friends, but more patients than controls had begun to use 'to feel better'. People who reported their reason for first using cannabis to 'feel better' were more likely to progress to heavy use and develop a psychotic disorder than those reporting 'because of friends'. [ABSTRACT FROM AUTHOR]- Published
- 2023
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24. Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study.
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Trotta, Giulia, Rodriguez, Victoria, Quattrone, Diego, Spinazzola, Edoardo, Tripoli, Giada, Gayer-Anderson, Charlotte, Freeman, Tom P, Jongsma, Hannah E, Sideli, Lucia, Aas, Monica, Stilo, Simona A, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Tortelli, Andrea, and Schürhoff, Franck
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SUBSTANCE abuse prevention ,ADVERSE childhood experiences ,CANNABIS (Genus) ,SUBSTANCE abuse ,PSYCHOSES ,CASE-control method ,QUESTIONNAIRES ,RESEARCH funding ,PSYCHOTHERAPY - Abstract
Background: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0–11 years), and late (12–17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. Results: The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. Conclusions: Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse. [ABSTRACT FROM AUTHOR]
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- 2023
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25. Lifestyles and Quality of Life of People with Mental Illness During the COVID-19 Pandemic
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Tripoli, Giada, primary, Lo Duca, Sofia, additional, Ferraro, Laura, additional, Zahid, Uzma, additional, Mineo, Raffaella, additional, Seminerio, Fabio, additional, Bruno, Alessandra, additional, Di Giorgio, Vanessa, additional, Maniaci, Giuseppe, additional, Marrazzo, Giovanna, additional, Sartorio, Crocettarachele, additional, Scaglione, Alessandra, additional, La Barbera, Daniele, additional, and La Cascia, Caterina, additional
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- 2023
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26. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study
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D'Andrea, Giuseppe, primary, Lal, Jatin, additional, Tosato, Sarah, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E., additional, Stilo, Simona A., additional, van der Ven, Els, additional, Quattrone, Diego, additional, Velthorst, Eva, additional, Berardi, Domenico, additional, Rossi Menezes, Paulo, additional, Arango, Celso, additional, Parellada, Mara, additional, Lasalvia, Antonio, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, La Barbera, Daniele, additional, Sideli, Lucia, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Tripoli, Giada, additional, Llorca, Pierre-Michel, additional, de Haan, Lieuwe, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Szöke, Andrei, additional, Muratori, Roberto, additional, Rutten, Bart P., additional, van Os, Jim, additional, Jones, Peter B., additional, Kirkbride, James B., additional, Murray, Robin M., additional, di Forti, Marta, additional, Tarricone, Ilaria, additional, and Morgan, Craig, additional
- Published
- 2022
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27. W73. GENETIC AND SOCIOENVIROMENTAL CORRELATES OF SYMPTOM DIMENSIONS ACROSS THE PSYCHOSIS SPECTRUM AT BASELINE AND 10-YEAR FOLLOW-UP
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Quattrone, Diego, Forti, Marta Di, Quattrone, Andrea, Lang, Yifei, Tripoli, Giada, Reininghaus, Ulrich, and Murray, Robin
- Published
- 2024
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- View/download PDF
28. Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI)
- Author
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Sideli, Lucia, Schimmenti, Adriano, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Aas, Monica, Alameda, Luis, Velthorst, Eva, Fisher, Helen L, Caretti, Vincenzo, Trotta, Giulia, Tripoli, Giada, Quattrone, Diego, Gayer-Anderson, Charlotte, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D'Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, Jose Luis, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E, Jones, Peter B, Kirkbride, James B, Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P, Di Forti, Marta, Morgan, Craig, Murray, Robin M, EU-GEI WP2 Group, Sideli, Lucia, Schimmenti, Adriano, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Aas, Monica, Alameda, Lui, Velthorst, Eva, Fisher, Helen L, Caretti, Vincenzo, Trotta, Giulia, Tripoli, Giada, Quattrone, Diego, Gayer-Anderson, Charlotte, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D'Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, Jose Lui, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E, Jones, Peter B, Kirkbride, James B, Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P, Di Forti, Marta, Morgan, Craig, Murray, Robin M, Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Dutch Research Council, Economic and Social Research Council (UK), Kings College London, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alicia Koplowitz, Fundación Alonso Lozano, NIHR Biomedical Research Centre (UK), Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), and RS: MHeNs - R3 - Neuroscience
- Subjects
Affective Disorders, Psychotic ,Intelligence Tests ,STRESS ,childhood abuse ,BIPOLAR DISORDER ,ASSOCIATION ,schizophrenia ,Psychiatry and Mental health ,Psychotic Disorders ,IQ ,ADVERSITIES ,Case-Control Studies ,ONSET ,RELIABILITY ,PHYSICAL ABUSE ,Humans ,childhood neglect ,psychosis ,Child Abuse ,VALIDITY ,Child ,Regular Articles ,TRAUMA - Abstract
[Background and hypothesis] Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment, and IQ would be stronger among patients with affective psychoses compared to those with nonaffective psychoses., [Study Design] 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ., [Study Results] In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and nonaffective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses., [Conclusions] Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls., The EU-GEI Study is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme, and Grant 2012/0417-0 from the São Paulo Research Foundation. B.P.F. Rutten is funded by a VIDI award (no. 91.718.336) from the Netherlands Scientific Organization. H. L. Fisher, C. Gayer-Anderson, and C. Morgan are supported by the Economic and Social Research Council (ESRC) Centre for Society and Mental Health at King’s College London [ES/S012567/1]. C. Arango has received support by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, “A way of making Europe”, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements, FP7- HEALTH-2013-2.2.1-2-603196 (Project PSYSCAN) and FP7- HEALTH-2013-2.2.1-2-602478 (Project METSY); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916, Project PRISM, and grant agreement No 777394, Project AIMS-2-TRIALS), Fundación Familia Alonso and Fundación Alicia Koplowitz. J.B. Kirkbride is supported by the NIHR University College London Hospital Biomedical Research Centre.
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- 2022
29. Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study
- Author
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Misra, Supriya, Gelaye, Bizu, Williams, David R, Koenen, Karestan C, Borba, Christina P C, Quattrone, Diego, Di Forti, Marta, Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Ferraro, Laura, Tarricone, Ilaria, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, van Os, Jim, Murray, Robin M, Gayer-Anderson, Charlotte, Morgan, Craig, Misra, Supriya, Gelaye, Bizu, Williams, David R, Koenen, Karestan C, Borba, Christina P C, Quattrone, Diego, Di Forti, Marta, Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Ferraro, Laura, Tarricone, Ilaria, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, van Os, Jim, Murray, Robin M, Gayer-Anderson, Charlotte, and Morgan, Craig
- Abstract
BACKGROUND: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority.METHODS: We used data from the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2, a population-based case-control study of incident psychotic disorders in 17 catchment sites across six countries. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between perceived discrimination and psychosis using mixed-effects logistic regression models. We used stratified and mediation analyses to explore differences for minority ethnic groups.RESULTS: Reporting any perceived experience of major discrimination (e.g. unfair treatment by police, not getting hired) was higher in cases than controls (41.8% v. 34.2%). Pervasive experiences of discrimination (≥3 types) were also higher in cases than controls (11.3% v. 5.5%). In fully adjusted models, the odds of psychosis were 1.20 (95% CI 0.91-1.59) for any discrimination and 1.79 (95% CI 1.19-1.59) for pervasive discrimination compared with no discrimination. In stratified analyses, the magnitude of association for pervasive experiences of discrimination appeared stronger for minority ethnic groups (OR = 1.73, 95% CI 1.12-2.68) than the ethnic majority (OR = 1.42, 95% CI 0.65-3.10). In exploratory mediation analysis, pervasive discrimination minimally explained excess risk among minority ethnic groups (5.1%).CONCLUSIONS: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups.
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- 2022
30. Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI)
- Author
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European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Dutch Research Council, Economic and Social Research Council (UK), Kings College London, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alicia Koplowitz, Fundación Alonso Lozano, NIHR Biomedical Research Centre (UK), Sideli, Lucia, Schimmenti, Adriano, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Aas, Monica, Alameda, Luis, Velthorst, Eva, Fisher, Helen L., Caretti, Vincenzo, Trotta, Giulia, Tripoli, Giada, Quattrone, Diego, Gayer-Anderson, Charlotte, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D'Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, José Luis, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P. F., Di Forti, Marta, Morgan, Craig, Murray, Robin M., European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Dutch Research Council, Economic and Social Research Council (UK), Kings College London, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alicia Koplowitz, Fundación Alonso Lozano, NIHR Biomedical Research Centre (UK), Sideli, Lucia, Schimmenti, Adriano, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Aas, Monica, Alameda, Luis, Velthorst, Eva, Fisher, Helen L., Caretti, Vincenzo, Trotta, Giulia, Tripoli, Giada, Quattrone, Diego, Gayer-Anderson, Charlotte, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D'Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, José Luis, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P. F., Di Forti, Marta, Morgan, Craig, and Murray, Robin M.
- Abstract
[Background and hypothesis] Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment, and IQ would be stronger among patients with affective psychoses compared to those with nonaffective psychoses., [Study Design] 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ., [Study Results] In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and nonaffective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses., [Conclusions] Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.
- Published
- 2022
31. Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case-Control Study
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Hersenen-Medisch 1, Brain, Tripoli, Giada, Quattrone, Diego, Ferraro, Laura, Gayer-Anderson, Charlotte, La Cascia, Caterina, La Barbera, Daniele, Sartorio, Crocettarachele, Seminerio, Fabio, Rodriguez, Victoria, Tarricone, Ilaria, Berardi, Domenico, Jamain, Stéphane, Arango, Celso, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miquel, Sanjuán, Julio, Luis Santos, Jose, Arrojo, Manuel, Marta Del-Ben, Cristina, Rossi Menezes, Paulo, van der Ven, Els, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Tosato, Sarah, Lasalvia, Antonio, Richards, Alex, O'Donovan, Michael, Rutten, Bart P F, van Os, Jim, Morgan, Craig, Sham, Pak C, Di Forti, Marta, Murray, Robin M, Murray, Graham K, Hersenen-Medisch 1, Brain, Tripoli, Giada, Quattrone, Diego, Ferraro, Laura, Gayer-Anderson, Charlotte, La Cascia, Caterina, La Barbera, Daniele, Sartorio, Crocettarachele, Seminerio, Fabio, Rodriguez, Victoria, Tarricone, Ilaria, Berardi, Domenico, Jamain, Stéphane, Arango, Celso, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miquel, Sanjuán, Julio, Luis Santos, Jose, Arrojo, Manuel, Marta Del-Ben, Cristina, Rossi Menezes, Paulo, van der Ven, Els, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Tosato, Sarah, Lasalvia, Antonio, Richards, Alex, O'Donovan, Michael, Rutten, Bart P F, van Os, Jim, Morgan, Craig, Sham, Pak C, Di Forti, Marta, Murray, Robin M, and Murray, Graham K
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- 2022
32. Migration history and risk of psychosis: results from the multinational EU-GEI study
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Hersenen-Medisch 1, Brain, Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E, Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A, Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, Bernardo, Miguel, Sanjuán, Iulio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Berardi, Domenico, Murray, Robin M, Morgan, Craig, Hersenen-Medisch 1, Brain, Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E, Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A, Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, Bernardo, Miguel, Sanjuán, Iulio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Berardi, Domenico, Murray, Robin M, and Morgan, Craig
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- 2022
33. 30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed Into the Developmental Risk Factor Model of Psychosis
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Murray, Robin M, Bhavsar, Vishal, Tripoli, Giada, and Howes, Oliver
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- 2017
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34. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.
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Rodriguez, Victoria, Alameda, Luis, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Spinazzola, Edoardo, Trotta, Giulia, Jongsma, Hannah E., Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Bonora, Elena, Jamain, Stéphane, Selten, Jean-Paul, Velthorst, Eva, and de Haan, Lieuwe
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GENETICS ,CONFIDENCE intervals ,SCHIZOPHRENIA ,PSYCHOSES ,MULTIPLE regression analysis ,RISK assessment ,AFFECTIVE disorders ,DISEASE susceptibility ,GENOTYPES ,ODDS ratio ,PREDICTION models - Abstract
Background: Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of the associated variants can be summarised as a polygenic risk score (PRS). Using data from the EUropean Network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) first episode case–control study, we aimed to test whether PRSs for three major psychiatric disorders (SZ, BD, D) and for intelligent quotient (IQ) as a neurodevelopmental proxy, can discriminate affective psychosis (AP) from schizophrenia-spectrum disorder (SSD). Methods: Participants (842 cases, 1284 controls) from 16 European EU-GEI sites were successfully genotyped following standard quality control procedures. The sample was stratified based on genomic ancestry and analyses were done only on the subsample representing the European population (573 cases, 1005 controls). Using PRS for SZ, BD, D, and IQ built from the latest available summary statistics, we performed simple or multinomial logistic regression models adjusted for 10 principal components for the different clinical comparisons. Results: In case–control comparisons PRS-SZ, PRS-BD and PRS-D distributed differentially across psychotic subcategories. In case–case comparisons, both PRS-SZ [odds ratio (OR) = 0.7, 95% confidence interval (CI) 0.54–0.92] and PRS-D (OR = 1.31, 95% CI 1.06–1.61) differentiated AP from SSD; and within AP categories, only PRS-SZ differentiated BD from psychotic depression (OR = 2.14, 95% CI 1.23–3.74). Conclusions: Combining PRS for severe psychiatric disorders in prediction models for psychosis phenotypes can increase discriminative ability and improve our understanding of these phenotypes. Our results point towards the potential usefulness of PRSs in specific populations such as high-risk or early psychosis phases. [ABSTRACT FROM AUTHOR]
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- 2023
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35. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study.
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Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodriguez, Victoria, Vassos, Evangelos, Sham, Pak, Tripoli, Giada, Cascia, Caterina La, Barbera, Daniele La, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, and Llorca, Pierre-Michel
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SCHIZOPHRENIA risk factors ,CONFIDENCE intervals ,PSYCHOSES ,CASE-control method ,RISK assessment ,RESEARCH funding ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,ODDS ratio ,CHILDREN - Abstract
Background: A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone. Methods: We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case–control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)
exposure and PRS − ORexposure − ORPRS + 1] with adjustment for potential confounders. Results: There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) −1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI −6.25 to 20.88). Conclusions: Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates. [ABSTRACT FROM AUTHOR]- Published
- 2023
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36. Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use
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Ferraro, Laura, La Cascia Caterina, Quattrone, Diego, Sideli, Lucia, Matranga, Domenica, Capuccio, Veronica, Tripoli, Giada, Gayer-Anderson, Charlotte, Morgan, Craig, Sami Musa, B., Sham, Pak, de Haan Lieuwe, Velthorst, Eva, Jongsma Hannah, E., Kirkbride James, B, Rutten Bart, P. F., Richards Alexander, L, Roldan, Laura, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Sanjuan, Julio, Santos Jose Luis, Arrojo, Manuel, Tarricone, Ilaria, Tortelli, Andrea, Szöke, Andrei, Del-Ben Cristina Marta, Selten, Jean-Paul, Lynskey, Michael, Jones Peter, B., Van Os Jim, La Barbera Daniele, Eu-Gei WP2 Group (Amoretti, S., Baudin, G., Beards, S., Berardi, D., Bonetto, C., Cabrera, B., Carracedo, A., Charpeaud, T., Costas, J., Cristofalo, D., Cuadrado, P., Ferchiou, A., Franke, N., Frijda, F., García Bernardo, E., Garcia-Portilla, P., González Peñas, J., González, E., Hubbard, K., Jamain, S., Jiménez-López, E., Lasalvia, A., Leboyer, M., López Montoya, G., Lorente-Rovira, E., Díaz-Caneja, C. M., Marcelino Loureiro, C., Marrazzo, G., Martínez, C., Matteis, M., Messchaart, E., Moltó, M. D., Moreno, C., Juan, N., Olmeda, M. S., Parellada, M., Pignon, B., Rapado, M., Richard, J. -R., Rodríguez Solano, J. J., Rossi Menezes, P., Ruggeri, M., Sáiz, P. A., Sánchez-Gutierrez, T., Sánchez, E., Sartorio, C., Schürhoff, F., Seminerio, F., Shuhama, R., Stilo, S. A., Termorshuizen, F., Tosato, S., Tronche, A. -M., Van Dam, D., Van Der Ven, E. )., Murray Robin, M., Di Forti Marta, Ferraro, Laura, La Cascia, Caterina, Quattrone, Diego, Sideli, Lucia, Matranga, Domenica, Capuccio, Veronica, Tripoli, Giada, Gayer-Anderson, Charlotte, Morgan, Craig, Sami, Musa B, Sham, Pak, de Haan, Lieuwe, Velthorst, Eva, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, Richards, Alexander L, Roldan, Laura, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Sanjuan, Julio, Santos, Jose Lui, Arrojo, Manuel, Tarricone, Ilaria, Tortelli, Andrea, Szöke, Andrei, Del-Ben, Cristina Marta, Selten, Jean-Paul, Lynskey, Michael, Jones, Peter B, Van Os, Jim, La Barbera, Daniele, Murray, Robin M, Di Forti, Marta, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, APH - Mental Health, MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, and RS: MHeNs - R2 - Mental Health
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Male ,cognition ,Intelligence ,Comorbidity ,SUBSTANCE USE DISORDERS ,0302 clinical medicine ,Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat ,Medicine ,PREDICTORS ,RISK ,education ,education.field_of_study ,biology ,Cognition ,Middle Aged ,Psychosocial Functioning ,sociability ,Psychiatry and Mental health ,Schizophrenia ,Female ,Marijuana Use ,Social Adjustment ,MENTAL-HEALTH ,Adult ,medicine.medical_specialty ,Psychosis ,Adolescent ,Population ,1ST EPISODE ,DRUG-USE ,preillness ,Settore MED/01 - Statistica Medica ,Young Adult ,03 medical and health sciences ,AGE ,Settore M-PSI/08 - Psicologia Clinica ,Humans ,Cognitive skill ,Psychiatry ,Settore MED/25 - Psichiatria ,business.industry ,Case-control study ,preillne ,biology.organism_classification ,medicine.disease ,EDUCAÇÃO ,030227 psychiatry ,schizophrenia ,Psychotic Disorders ,Case-Control Studies ,ONSET ,Cannabis ,NEUROCOGNITION ,business ,marijuana ,Neurocognitive ,030217 neurology & neurosurgery ,Regular Articles - Abstract
Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired and less socially withdrawn in their premorbid life. Using a dataset comprising 948 patients with first-episode psychosis (FEP) and 1313 population controls across 6 countries, we examined the extent to which IQ and both early academic (Academic Factor [AF]) and social adjustment (Social Factor [SF]) are related to the lifetime frequency of cannabis use in both patients and controls. We expected a higher IQ and a better premorbid social adjustment in psychotic patients who had ever used cannabis compared to patients without any history of use. We did not expect such differences in controls. In both patients and controls, IQ was 3 points higher among occasional-users than in never-users (mean difference [Mdiff] = 2.9, 95% CI = [1.2, 4.7]). Both cases and control daily-users had lower AF compared to occasional (Mdiff = −0.3, 95% CI = [−0.5; −0.2]) and never-users (Mdiff = −0.4, 95% CI = [−0.6; −0.2]). Finally, patient occasional (Mdiff = 0.3, 95% CI = [0.1; 0.5]) and daily-users (Mdiff = 0.4, 95% CI = [0.2; 0.6]) had better SF than their never-using counterparts. This difference was not present in controls (Fgroup*frequency(2, 2205) = 4.995, P = .007). Our findings suggest that the better premorbid social functioning of FEP with a history of cannabis use may have contributed to their likelihood to begin using cannabis, exposing them to its reported risk-increasing effects for Psychotic Disorders.
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- 2019
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37. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)
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Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, De Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., Van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Hubbard, Kathryn, Beards, Stephanie, Reininghaus, Ulrich, Tripoli, Giada, Stilo, Simona A., Roldán, Laura, López, Gonzalo, Matteis, Mario, Rapado, Marta, González, Emiliano, Martínez, Covadonga, Cuadrado, Pedro, Solano, José Juan Rodríguez, Carracedo, Angel, Costas, Javier, Bernardo, Enrique García, Sánchez, Emilio, Olmeda, Ma Soledad, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Jamain, Stéphane, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Loureiro, Camila Marcelino, Shuhama, Rosana, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Gayer-Anderson, Charlotte [0000-0003-1636-889X], Apollo - University of Cambridge Repository, Gayer-Anderson C., Jongsma H.E., Di Forti M., Quattrone D., Velthorst E., de Haan L., Selten J.-P., Szoke A., Llorca P.-M., Tortelli A., Arango C., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Parellada M., Tarricone I., Berardi D., Ruggeri M., Lasalvia A., Ferraro L., La Cascia C., La Barbera D., Menezes P.R., Del-Ben C.M., Hubbard K., Beards S., Reininghaus U., Tripoli G., Stilo S.A., Roldan L., Lopez G., Matteis M., Rapado M., Gonzalez E., Martinez C., Cuadrado P., Solano J.J.R., Carracedo A., Costas J., Bernardo E.G., Sanchez E., Olmeda M.S., Cabrera B., Lorente-Rovira E., Garcia-Portilla P., Jimenez-Lopez E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schurhoff F., Baudin G., Ferchiou A., Pignon B., Jamain S., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Sideli L., Seminerio F., Sartorio C., Marrazzo G., Loureiro C.M., Shuhama R., Tosato S., Bonetto C., Cristofalo D., Rutten B.P., van Os J., Jones P.B., Murray R.M., Kirkbride J.B., Morgan C., Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Lui, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, MUMC+: Hersen en Zenuw Centrum (3), ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and APH - Mental Health
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Male ,Health (social science) ,Epidemiology ,Ethnic group ,Ethnic Group ,Gene-environment interactions ,Environment–environment interactions ,0302 clinical medicine ,Ethnicity ,10. No inequality ,First episode ,RISK ,biology ,Incidence (epidemiology) ,Incidence ,CANNABIS ,Middle Aged ,Case-control ,First-episode psychosis ,3. Good health ,Europe ,Psychiatry and Mental health ,Case–control Environment–environment interactions EU-GEI First-episode psychosis Gene–environment interactions Incidence ,Case–control ,EU-GEI ,Gene–environment interactions ,Schizophrenia ,Cohort ,Female ,Psychology ,Case-Control Studie ,Brazil ,Human ,Adult ,medicine.medical_specialty ,Social Psychology ,Adolescent ,Study Protocols and Samples ,DISORDERS ,Environment–environment interaction ,Representativeness heuristic ,03 medical and health sciences ,Young Adult ,PSYCHOSIS ,AGE ,First-episode psychosi ,Environment-environment interactions ,medicine ,Humans ,Gene–environment interaction ,Settore MED/25 - Psichiatria ,METAANALYSIS ,biology.organism_classification ,medicine.disease ,030227 psychiatry ,Case-Control Studies ,Gene-Environment Interaction ,Cannabis ,CHILDHOOD ADVERSITIES ,030217 neurology & neurosurgery ,Demography - Abstract
Funder: FP7 Ideas: European Research Council; doi: http://dx.doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2010-241909, Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.
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- 2020
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38. Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case–Control Study
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Tripoli, Giada, primary, Quattrone, Diego, additional, Ferraro, Laura, additional, Gayer-Anderson, Charlotte, additional, La Cascia, Caterina, additional, La Barbera, Daniele, additional, Sartorio, Crocettarachele, additional, Seminerio, Fabio, additional, Rodriguez, Victoria, additional, Tarricone, Ilaria, additional, Berardi, Domenico, additional, Jamain, Stéphane, additional, Arango, Celso, additional, Tortelli, Andrea, additional, Llorca, Pierre-Michel, additional, de Haan, Lieuwe, additional, Velthorst, Eva, additional, Bobes, Julio, additional, Bernardo, Miquel, additional, Sanjuán, Julio, additional, Luis Santos, Jose, additional, Arrojo, Manuel, additional, Marta Del-Ben, Cristina, additional, Rossi Menezes, Paulo, additional, van der Ven, Els, additional, Jones, Peter B, additional, Jongsma, Hannah E, additional, Kirkbride, James B, additional, Tosato, Sarah, additional, Lasalvia, Antonio, additional, Richards, Alex, additional, O’Donovan, Michael, additional, Rutten, Bart P F, additional, van Os, Jim, additional, Morgan, Craig, additional, Sham, Pak C, additional, Di Forti, Marta, additional, Murray, Robin M, additional, and Murray, Graham K, additional
- Published
- 2022
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39. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study
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Rodriguez, Victoria, primary, Alameda, Luis, additional, Quattrone, Diego, additional, Tripoli, Giada, additional, Gayer-Anderson, Charlotte, additional, Spinazzola, Edoardo, additional, Trotta, Giulia, additional, Jongsma, Hannah E., additional, Stilo, Simona, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, La Barbera, Daniele, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tarricone, Ilaria, additional, Bonora, Elena, additional, Jamain, Stéphane, additional, Selten, Jean-Paul, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James, additional, Jones, Peter B., additional, Rutten, Bart P., additional, Richards, Alexander, additional, Sham, Pak C., additional, O'Donovan, Michael, additional, Van Os, Jim, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Murray, Robin M., additional, and Vassos, Evangelos, additional
- Published
- 2022
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40. First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.
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Ferraro, Laura, Quattrone, Diego, Barbera, Daniele La, Cascia, Caterina La, Morgan, Craig, Kirkbride, James B, Cardno, Alastair G, Sham, Pak, Tripoli, Giada, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Szoke, Andrei, Tarricone, Ilaria, Bernardo, Miquel, Rodriguez, Victoria, Stilo, Simona A, Gayer-Anderson, Charlotte, Haan, Lieuwe de, and Velthorst, Eva
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SCHIZOPHRENIA risk factors ,ACADEMIC achievement evaluation ,MENTAL depression risk factors ,SUBSTANCE abuse ,CANNABIS (Genus) ,CONFIDENCE intervals ,PSYCHOSES ,GENETIC variation ,RISK assessment ,COMPARATIVE studies ,DESCRIPTIVE statistics ,SOCIAL skills ,CLUSTER analysis (Statistics) ,BIPOLAR disorder ,DISEASE risk factors ,DISEASE complications ,CHILDREN ,ADOLESCENCE - Abstract
Cluster studies identified a subgroup of patients with psychosis whose premorbid adjustment deteriorates before the onset, which may reflect variation in genetic influence. However, other studies reported a complex relationship between distinctive patterns of cannabis use and cognitive and premorbid impairment that is worthy of consideration. We examined whether: (1) premorbid social functioning (PSF) and premorbid academic functioning (PAF) in childhood and adolescence and current intellectual quotient (IQ) define different clusters in 802 first-episode of psychosis (FEP) patients; resulting clusters vary in (2) polygenic risk scores (PRSs) for schizophrenia (SCZ_PRS), bipolar disorder (BD_PRS), major depression (MD_PRS), and IQ (IQ_PRS), and (3) patterns of cannabis use, compared to 1,263 population-based controls. Four transdiagnostic clusters emerged (BIC = 2268.5): (1) high-cognitive-functioning (n = 205), with the highest IQ (Mean = 106.1, 95% CI: 104.3, 107.9) and PAF, but low PSF. (2) Low-cognitive-functioning (n = 223), with the lowest IQ (Mean = 73.9, 95% CI: 72.2, 75.7) and PAF, but normal PSF. (3) Intermediate (n = 224) (Mean_IQ = 80.8, 95% CI: 79.1, 82.5) with low-improving PAF and PSF. 4) Deteriorating (n = 150) (Mean_IQ = 80.6, 95% CI: 78.5, 82.7), with normal-deteriorating PAF and PSF. The PRSs explained 7.9% of between-group membership. FEP had higher SCZ_PRS than controls [ F (4,1319) = 20.4, P < .001]. Among the clusters, the deteriorating group had lower SCZ_PRS and was likelier to have used high-potency cannabis daily. Patients with FEP clustered according to their premorbid and cognitive abilities. Pronounced premorbid deterioration was not typical of most FEP, including those more strongly predisposed to schizophrenia, but appeared in a cluster with a history of high-potency cannabis use. [ABSTRACT FROM AUTHOR]
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- 2023
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41. Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study
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Tripoli, Giada, Quattrone, Diego, Ferraro, Laura, Gayer-Anderson, Charlotte, Rodriguez, Victoria, La Cascia, Caterina, La Barbera, Daniele, Sartorio, Crocettarachele, Seminerio, Fabio, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Llorca, Pierre-Michel, De Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, EU-GEI WP2 Group, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Lasalvia, Antonio, Tosato, Sarah, Richards, Alex, O'Donovan, Michael, Rutten, Bart Pf, Os, Jim Van, Morgan, Craig, Sham, Pak C, Murray, Robin M, Murray, Graham K, Di Forti, Marta, Tripoli, Giada [0000-0002-9257-6677], and Apollo - University of Cambridge Repository
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Adult ,Male ,First episode psychosis ,psychotic-like experiences ,Adolescent ,Intelligence ,Middle Aged ,Delusions ,symptom dimensions ,Young Adult ,Cognition ,Bias ,Psychotic Disorders ,IQ ,Case-Control Studies ,polygenic risk score ,Humans ,Cognitive Dysfunction ,Female ,jumping to conclusions ,Problem Solving - Abstract
BACKGROUND: The 'jumping to conclusions' (JTC) bias is associated with both psychosis and general cognition but their relationship is unclear. In this study, we set out to clarify the relationship between the JTC bias, IQ, psychosis and polygenic liability to schizophrenia and IQ.; METHODS: A total of 817 first episode psychosis patients and 1294 population-based controls completed assessments of general intelligence (IQ), and JTC, and provided blood or saliva samples from which we extracted DNA and computed polygenic risk scores for IQ and schizophrenia.; RESULTS: The estimated proportion of the total effect of case/control differences on JTC mediated by IQ was 79%. Schizophrenia polygenic risk score was non-significantly associated with a higher number of beads drawn (B = 0.47, 95% CI -0.21 to 1.16, p = 0.17); whereas IQ PRS (B = 0.51, 95% CI 0.25-0.76, p < 0.001) significantly predicted the number of beads drawn, and was thus associated with reduced JTC bias. The JTC was more strongly associated with the higher level of psychotic-like experiences (PLEs) in controls, including after controlling for IQ (B = -1.7, 95% CI -2.8 to -0.5, p = 0.006), but did not relate to delusions in patients.; CONCLUSIONS: Our findings suggest that the JTC reasoning bias in psychosis might not be a specific cognitive deficit but rather a manifestation or consequence, of general cognitive impairment. Whereas, in the general population, the JTC bias is related to PLEs, independent of IQ. The work has the potential to inform interventions targeting cognitive biases in early psychosis.
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- 2020
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42. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study
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Quattrone, Diego, Reininghaus, Ulrich, Richards, Alex L., Tripoli, Giada, Ferraro, Laura, Quattrone, Andrea, Marino, Paolo, Rodriguez, Victoria, Spinazzola, Edoardo, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Jones, Peter B., La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Bonora, Elena, Tosato, Sarah, Lasalvia, Antonio, Szöke, Andrei, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Del Ben, Cristina Marta, Menezes, Paulo Rossi, Llorca, Pierre-Michel, Santos, Jose Luis, Sanjuán, Julio, Arrojo, Manuel, Tortelli, Andrea, Velthorst, Eva, Berendsen, Steven, De Haan, Lieuwe, Rutten, Bart P. F., Lynskey, Michael T., Freeman, Tom P., Kirkbride, James B., Sham, Pak C., O’Donovan, Michael C., Cardno, Alastair G., Vassos, Evangelos, Van Os, Jim, Morgan, Craig, Murray, Robin M., Lewis, Cathryn M., Di Forti, Marta, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Fraguas, David, Castro, Marta Rapado, Andreu-Bernabeu, Álvaro, López, Gonzalo, Matteis, Mario, González, Emiliano, Durán-Cutilla, Manuel, Díaz-Caneja, Covadonga M., Cuadrado, Pedro, Rodríguez Solano, José Juan, Carracedo, Angel, Costas, Javier, Sánchez, Emilio, Amoretti, Silvia, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Jamain, Stéphane, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Bonetto, Chiara, Cristofalo, Doriana, Berardi, Domenico, Seri, Marco, D’Andrea, Giuseppe, Quattrone, Diego [0000-0002-6051-8309], Richards, Alex L. [0000-0003-3218-7247], Marino, Paolo [0000-0003-3571-1753], Rodriguez, Victoria [0000-0003-0383-0846], Jones, Peter B. [0000-0002-0387-880X], Tosato, Sarah [0000-0002-9665-7538], Bernardo, Miquel [0000-0001-8748-6717], Bobes, Julio [0000-0003-2187-4033], Del Ben, Cristina Marta [0000-0003-0145-9975], Menezes, Paulo Rossi [0000-0001-6330-3314], Llorca, Pierre-Michel [0000-0001-7438-8990], Rutten, Bart P. F. [0000-0002-9834-6346], Kirkbride, James B. [0000-0003-3401-0824], O’Donovan, Michael C. [0000-0001-7073-2379], Vassos, Evangelos [0000-0001-6363-0438], Murray, Robin M. [0000-0003-0829-0519], Lewis, Cathryn M. [0000-0002-8249-8476], and Apollo - University of Cambridge Repository
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45 ,692/699/476/1799 ,692/53/2423 ,45/43 ,article ,631/208/2489 - Abstract
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
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- 2021
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43. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Cristóbal-Narváez, Paula, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
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- 2021
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44. Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case−control study.
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Misra, Supriya, Gelaye, Bizu, Williams, David R., Koenen, Karestan C., Borba, Christina P.C., Quattrone, Diego, Di Forti, Marta, Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Ferraro, Laura, Tarricone, Ilaria, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, and de Haan, Lieuwe
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MINORITIES ,CONFIDENCE intervals ,PSYCHOSES ,CASE-control method ,RISK assessment ,T-test (Statistics) ,DESCRIPTIVE statistics ,FACTOR analysis ,CHI-squared test ,ETHNIC groups ,ODDS ratio ,LOGISTIC regression analysis ,STATISTICAL models ,DATA analysis software ,PERCEIVED discrimination ,DOSE-response relationship in biochemistry - Abstract
Background: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority. Methods: We used data from the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2, a population-based case−control study of incident psychotic disorders in 17 catchment sites across six countries. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between perceived discrimination and psychosis using mixed-effects logistic regression models. We used stratified and mediation analyses to explore differences for minority ethnic groups. Results: Reporting any perceived experience of major discrimination (e.g. unfair treatment by police, not getting hired) was higher in cases than controls (41.8% v. 34.2%). Pervasive experiences of discrimination (≥3 types) were also higher in cases than controls (11.3% v. 5.5%). In fully adjusted models, the odds of psychosis were 1.20 (95% CI 0.91–1.59) for any discrimination and 1.79 (95% CI 1.19–1.59) for pervasive discrimination compared with no discrimination. In stratified analyses, the magnitude of association for pervasive experiences of discrimination appeared stronger for minority ethnic groups (OR = 1.73, 95% CI 1.12–2.68) than the ethnic majority (OR = 1.42, 95% CI 0.65–3.10). In exploratory mediation analysis, pervasive discrimination minimally explained excess risk among minority ethnic groups (5.1%). Conclusions: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups. [ABSTRACT FROM AUTHOR]
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- 2022
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45. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study
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Aas, Monica, primary, Alameda, Luis, additional, Di Forti, Marta, additional, Quattrone, Diego, additional, Dazzan, Paola, additional, Trotta, Antonella, additional, Ferraro, Laura, additional, Rodriguez, Victoria, additional, Vassos, Evangelos, additional, Sham, Pak, additional, Tripoli, Giada, additional, Cascia, Caterina La, additional, Barbera, Daniele La, additional, Tarricone, Ilaria, additional, Muratori, Roberto, additional, Berardi, Domenico, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Szöke, Andrei, additional, Llorca, Pierre-Michel, additional, Arango, Celso, additional, Tortelli, Andrea, additional, de Haan, Lieuwe, additional, Velthorst, Eva, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Menezes, Paulo Rossi, additional, Selten, Jean-Paul, additional, Jones, Peter B., additional, Jongsma, Hannah E., additional, Kirkbride, James B., additional, Rutten, Bart P. F., additional, van Os, Jim, additional, Gayer-Anderson, Charlotte, additional, Murray, Robin M., additional, and Morgan, Craig, additional
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- 2021
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46. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
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- 2021
47. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study
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Hersenen-Medisch 1, Brain, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., Quattrone, Diego, Hersenen-Medisch 1, Brain, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., and Quattrone, Diego
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- 2021
48. Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and controls
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Hersenen-Medisch 1, Brain, Sami, Musa, Quattrone, Diego, Ferraro, Laura, Tripoli, Giada, Cascia, Erika La, Gayer-Anderson, Charlotte, Selten, Jean-Paul, Arango, Celso, Bernardo, Miguel, Tarricone, Ilaria, Tortelli, Andrea, Gatto, Giusy, Del Peschio, Simona, Del-Ben, Cristina Marta, Rutten, Bart P, Jones, Peter B, van Os, Jim, de Haan, Lieuwe, Morgan, Craig, Lewis, Cathryn, Bhattacharyya, Sagnik, Freeman, Tom P, Lynskey, Michael, Murray, Robin M, Forti, Marta Di, Hersenen-Medisch 1, Brain, Sami, Musa, Quattrone, Diego, Ferraro, Laura, Tripoli, Giada, Cascia, Erika La, Gayer-Anderson, Charlotte, Selten, Jean-Paul, Arango, Celso, Bernardo, Miguel, Tarricone, Ilaria, Tortelli, Andrea, Gatto, Giusy, Del Peschio, Simona, Del-Ben, Cristina Marta, Rutten, Bart P, Jones, Peter B, van Os, Jim, de Haan, Lieuwe, Morgan, Craig, Lewis, Cathryn, Bhattacharyya, Sagnik, Freeman, Tom P, Lynskey, Michael, Murray, Robin M, and Forti, Marta Di
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- 2021
49. IS THE ERA OF CANDIDATE GENES X CANNABIS USE REALLY DEAD?
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Quattrone, Diego, Lewis, Cathryn, Richards, Alexander, Vassos, Evangelos, Gayer-Anderson, Charlotte, Ferraro, Laura, Tripoli, Giada, Rutten, Bart, O'Donovan, Michael, Morgan, Craig, Van Os, Jim, Sham, Pak, Reininghaus, Ulrich, Murray, Robin, Forti, Marta Di, Quattrone, Diego, Lewis, Cathryn, Richards, Alexander, Vassos, Evangelo, Gayer-Anderson, Charlotte, Ferraro, Laura, Tripoli, Giada, Rutten, Bart, O'Donovan, Michael, Morgan, Craig, Van Os, Jim, Sham, Pak, Reininghaus, Ulrich, Murray, Robin, and Forti, Marta Di
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DRD2, psychosis, genes ,Settore MED/25 - Psichiatria - Abstract
Background: Historically, gene X environment examinations in psychotic disorders have employed candidate gene methods and environmental determinants impacting on similar biological mechanisms. However, genome wide association studies (GWAS) show that many variants associated with schizophrenia have a modest effect size on risk. In this respect, it is unclear whether the effect of cannabis on psychosis phenotypes is modified by a few genes, e.g. those involved in dopamine signalling, or by the overall genetic susceptibility to schizophrenia. Indeed, candidate gene approaches might be complementary to GWAS to test gene X cannabis interaction. We aimed to investigate the interactive effects of cannabis use on variants in DRD2 gene on: 1) the risk of developing first episode psychosis (FEP); and 2) the frequency of positive symptoms at FEP. We undertook a replication study of previous Gene X Cannabis interactions for DRD2 (rs1076560); further, we tested interactions between cannabis use and any SNP associated with schizophrenia within DRD2 gene in the last Psychiatric Genomics Consortium (PGC) GWAS. Methods: We genotyped ∼830 FEP patients and ∼1200 controls recruited across six countries as part of the large EUGEI study. OPerational CRITeria system and Cannabis Experience Questionnaire were used for evaluating psychopathology and patterns of cannabis use. Dimensions of psychopathology, which included a specific dimension of positive symptoms, were estimated using multidimensional item response modelling in Mplus. We tested for an interaction between risk allele count and daily cannabis use on: 1) the risk of psychotic disorder in the case-control study; 2) the positive symptom dimension in the case-only sample. Only one SNP in DRD2 was significantly associated with schizophrenia in the PGC study, so we tested for interaction with rs2514218, in addition to rs1076560. These regression models, conducted in STATA 14, were adjusted for age, gender, ethnicity, 10 principal components (PC) for population stratification and SNP-environment and SNP-PC interaction terms. Results were corrected for multiple testing of four SNPs (p
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- 2019
50. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA IMPACT ON JUMPING TO CONCLUSIONS? PRELIMINARY FINDINGS FROM THE EU-GEI CASE-CONTROL STUDY
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Tripoli, Giada, Quattrone, Diego, Gayer-Anderson, Charlotte, Rodríguez, Victoria, Benzian-Olsson, Natasha, Ferraro, Laura, La Cascia, Caterina, Sartorio, Crocettarachele, Sideli, Lucia, Seminerio, Fabio, La Barbera, Daniele, Morgan, Craig, Sham, Pak, Forti, Marta Di, Murray, Robin, Tripoli, Giada, Quattrone, Diego, Gayer-Anderson, Charlotte, Rodríguez, Victoria, Benzian-Olsson, Natasha, Ferraro, Laura, La Cascia, Caterina, Sartorio, Crocettarachele, Sideli, Lucia, Seminerio, Fabio, La Barbera, Daniele, Morgan, Craig, Sham, Pak, Forti, Marta Di, and Murray, Robin
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cognition, genes, schizoprenia ,Settore MED/25 - Psichiatria - Abstract
Background: Jumping to conclusions (JTC) is a reasoning and data gathering bias that results in the tendency to require less evidence and make hasty decisions. Preliminary work on reasoning bias focused primarily on the association with delusions, although jumping to conclusions has also been found in non-deluded schizophrenia (SZ) patients. Literature to date has shown JTC as a well-established bias in psychosis even at First Episode Psychosis (FEP), after remission, and in individuals with at risk mental state. Furthermore, JTC has been found to be associated with proneness to psychotic-like experiences in the general population. In teresting findings showed also an association with lower cognitive functioning in psychotic patients, and some degree of stability of JTC over the course of illness. Overall, findings to date could suggest a shared genetic liability between the occurrence of JTC and psychosis. The present study aims to investigate in a sample of FEP and healthy controls: 1) environment, cognitive, and clinical factors associated with JTC bias 2) whether the addition of SZ Polygenic Risk Score (PRS) explains any further variance in the model. Methods: We analyzed data on JTC (Beads task 60:40) in a sample of 503 FEP and 959 population controls for which genetic information was available, recruited as part as the EU-GEI study across UK, Netherlands, France, Spain, Italy and Brazil. In the first step, logistic regressions have been performed to predict JTC respectively in cases and controls considering as covariates: age, gender, level of education, IQ, country, frequency of cannabis use, population density, positive symptoms, and 20 principal components (PCs) for population stratification. In the second step, we estimated a model adding SZ PRS to the aforementioned terms. Results: Individuals coming from Brazil were about 6 times more likely to jump to conclusions in case group (OR=6.69; CI 95%=2.23-20.06; p=0.001) and around 5 times among controls (OR=4.76; CI 95%=2.28-9.93; p
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- 2019
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