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194 results on '"Tripathi, Pragya"'

3. Recent expansion of metabolic versatility in Diplonema papillatum, the model species of a highly speciose group of marine eukaryotes

Author

Valach, Matus, Moreira, Sandrine, Petitjean, Celine, Benz, Corinna, Butenko, Anzhelika, Flegontova, Olga, Nenarokova, Anna, Prokopchuk, Galina, Batstone, Tom, Lapébie, Pascal, Lemogo, Lionnel, Sarrasin, Matt, Stretenowich, Paul, Tripathi, Pragya, Yazaki, Euki, Nara, Takeshi, Henrissat, Bernard, Lang, B. Franz, Gray, Michael W., Williams, Tom A., Lukeš, Julius, and Burger, Gertraud

Published
2023
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4. Large Area Surface Texturing Through Electrical Discharge Micromachining Process for Inducing Hydrophobicity

Author

Singh, Mahavir, Tripathi, Pragya, Ramkumar, J., Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Shunmugam, M. S., editor, Doloi, Biswanath, editor, Ramesh, R., editor, and Prasanth, A. S., editor

Published
2023
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7. Simultaneous Orientational and Conformational Molecular Dynamics in Solid (1,1,2)-Trichloroethane

Author

Romanini, Michela, Mitsari, Efstratia, Tripathi, Pragya, Serra, Pablo, Zuriaga, Mariano, Tamarit, Josep Lluis, and Macovez, Roberto

Subjects
Physics - Chemical Physics
Abstract

The molecular dynamics in the ambient-pressure solid phase of (1,1,2)-trichloroethane is studied by means of broadband dielectric spectroscopy and molecular dynamics simulations. The dielectric spectra of polycrystalline samples obtained by crystallization from the liquid phase exhibit, besides a space-charge relaxation associated with accumulation of charges at crystalline domain boundaries, two loss features arising from dipolar molecular relaxations. The most prominent and slower of the two loss features is identified as a configurational leap of the molecules which involves a simultaneous change in spatial orientation and structural conformation, namely between two isomeric forms (gauche$^+$ and gauche$^-$) of opposite chirality. In this peculiar dynamic process, the positions of the three chlorine atoms in the crystal lattice remain unchanged, while those of the carbon and hydrogen atoms are modified. This dynamic process is responsible for the disorder observed in an earlier x-ray diffraction study and confirmed by our simulation, which is present only at temperatures relatively close to the melting point, starting 40 K below. The onset of the disorder is visible as an anomaly in the temperature dependence of the dc conductivity of the sample at exactly the same temperature. While the slower relaxation dynamics (combined isomerization/reorientation) becomes increasingly more intense on approaching the melting point, the faster dynamics exhibits significantly lower but constant dielectric strength. Based on our molecular dynamics simulations, we assign the faster relaxation to large fluctuations of the molecular dipole moments, partly due to large-angle librations of the chloroethane species.

Published
2018
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25. Statins Are Associated With Increased Insulin Resistance and Secretion

Author

Abbasi, Fahim, primary, Lamendola, Cindy, additional, Harris, Chelsea S., additional, Harris, Vander, additional, Tsai, Ming-Shian, additional, Tripathi, Pragya, additional, Abbas, Fakhar, additional, Reaven, Gerald M., additional, Reaven, Peter D., additional, Snyder, Michael P., additional, Kim, Sun H., additional, and Knowles, Joshua W., additional

Published
2021
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28. Pixantrone confers radiosensitization in KRAS mutated cancer cells by suppression of radiation-induced prosurvival pathways.

Author

Tripathi, Pragya, Soni, Ravi, Antra, and Tandon, Vibha

Subjects
*RAS oncogenes, *RAS proteins, *RADIATION-sensitizing agents, *DRUG repositioning, *CANCER cells, *PI3K/AKT pathway
Abstract

Radioresistance towards radiation therapy has generated the need for the development of radiosensitizers as a potential drug. KRAS mutation brings radioresistance in tumor cells. The present work proves sensitization of cancer cells towards radiotherapy through inhibition of KRAS activation. Acquiring a drug repurposing approach, the in-silico screening revealed that pixantrone, an antineoplastic drug, possesses a high affinity towards KRAS G12C and G12D subtypes. The SPR study suggests that maximum affinity of pixantrone was observed with KRAS G12C>WT>G12D and G12S. Pixantrone potentially inhibited the KRAS activation in stable transfectants G12C and G12D cell lines and radiosensitized distinct KRAS mutant subtype cells. The combination of pixantrone with radiation causes enhanced dsDNA breaks along with enhanced ATM expression, and increased late apoptosis. The preclinical studies on NCr-fox1nu xenograft mice showed potent inhibition of tumor progression and prolonged survival of mcie due to the radiosensitizing effect of pixantrone. Radiation-induced activation of key effector proteins of RAS downstream pathways, like MAPK and PI3K/Akt/mTOR pathways, were downregulated in tumor cells upon combination treatment. Interestingly, a robust upregulation of senescence marker p21 was observed in the tumor cells in combination treatment. These findings reveal a convergence between KRAS signaling, pixantrone treatment, and radiation conferring tumor cell death. [Display omitted] • Oncogenic KRAS causes radioresistance in tumor cells. • Pixantrone inhibits mutant KRAS and radiosensitizes cancer cells. • Radiation treatment upregulates MAPK and PI3K/Akt prosurvival pathway proteins in xenograft model. • Pixantrone in combination with radiation causes suppression of prosurvival pathway proteins, inhibiting tumor growth. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Polymorphism with Conformational Isomerism and Incomplete Crystallization in Solid Ethanolamine

Author

Négrier, Philippe, Romanini, Michela, Negrier, Philippe, Tripathi, Pragya, Lira, Kyriaki-Marina, Gournis, Dimitrios, Barrio, Maria, Pardo, Luis Carlos, Tamarit, Josep Lluis, Macovez, Roberto, Laboratoire Ondes et Matière d'Aquitaine (LOMA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de Catalunya [Barcelona] (UPC), Grup de Caracteritzacio de Materials, Departament de Fisica i Enginyeria Nuclear (GCM), Departament de Fisica i Enginyeria Nuclear (ETSEIB), Universitat Politècnica de Catalunya. Departament de Física, and Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials

Subjects
Materials science, Crystal structure, Molecular dynamics, Enginyeria dels materials [Àrees temàtiques de la UPC], law.invention, Crystal, Condensed Matter::Materials Science, law, Frustrated crystallization, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, General Materials Science, Dinàmica molecular, Physics::Chemical Physics, Crystallization, Supercooling, Ethane derivative, Conformational isomerism, ComputingMilieux_MISCELLANEOUS, Rietveld refinement, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemistry, Hidrogen, [CHIM.MATE]Chemical Sciences/Material chemistry, Condensed Matter Physics, Crystallography, Polymorphism (materials science), Metastable crystal phase, Hydrogen bond network, Powder diffraction, Hydrogen
Abstract

We employ calorimetry, Rietveld refinement of X-ray powder diffraction, broadband dielectric spectroscopy and molecular dynamics simulations, to investigate the phase behavior, crystal structure, dc conductivity and dielectric response of the condensed phases of ethanolamine (EAM), an ethane derivative with two distinct hydrogen-bonding groups. EAM is found to exhibit, besides its stable crystal phase, a metastable crystalline phase obtained from the supercooled liquid phase. The metastable phase can only be maintained at low temperature; upon heating an irreversible exothermic transformation to the stable crystal structure takes place at 210 K, with a low transition enthalpy of ca. 2.4 J/g. The observed polymorphism is accompanied by differences in the molecular conformation and degree of structural order. Each EAM molecule participates in six H-bonds in both crystalline phases. While the stable phase is fully ordered, the metastable phase appears to be characterized by a statistical disorder in the position of the hydrogen atoms and thus of the intramolecular conformation and intermolecular hydrogen bonding. Our molecular dynamics simulations suggest that such disorder is dynamic in character, and allow analyzing the dynamic H-bonding motif of the metastable phase in terms of composition, length and energy of the H-bonds, and molecular conformations involved. Charge conduction is mainly ionic in both crystalline phases and exhibits the typical temperature dependence of disordered solid electrolytes, rather than crystalline ones. Dielectric characterization indicates that, upon crystallization of liquid EAM, a small fraction of the sample (approximately 5%) remains amorphous, a situation similar to that reported for other H-bonded systems such as glycerol and nbutanol.

Published
2019

33. Other

Author

Nichite, Sachin, primary and Tripathi, Pragya, additional

Published
2013
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