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1. Shorter duration of slow wave sleep is related to symptoms of depression in patients with epilepsy

Author

Eyjolfsdóttir, Stefanía, Trinka, Eugen, and Höller, Yvonne

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Slow wave sleep duration and spectral abnormalities are related to both epilepsy and depression, but it is unclear how depressive symptoms in patients with epilepsy are affected by slow wave sleep duration and clinical factors, and how the spectral characteristics of slow wave sleep reflect a potential interaction of epilepsy and depression. Long-term video-EEG monitoring was conducted in 51 patients with focal epilepsy, 13 patients with generalized epilepsy, and 9 patients without epilepsy. Slow wave sleep segments were manually marked in the EEG and duration as well as EEG power spectra were extracted. Depressive symptoms were documented with the Beck Depression Inventory (BDI). At least mild depressive symptoms (BDI>9) were found among 23 patients with focal epilepsy, 5 patients with generalised epilepsy, and 6 patients who had no epilepsy diagnosis. Slow wave sleep duration was shorter for patients with at least mild depressive symptoms (p=.004), independently from epilepsy diagnosis, antiseizure medication, age, and sex. Psychoactive medication was associated with longer slow wave sleep duration (p=.008). Frontal sigma band power (13-15 Hz) during slow wave sleep was higher for patients without epilepsy and without depressive symptoms as compared to patients without depressive symptoms but with focal epilepsy (p=.005). Depressive symptoms affect slow wave sleep duration of patients with epilepsy similarly as in patients without epilepsy. Since reduced slow wave sleep can increase the likelihood of seizure occurrence, these results stress the importance of adequate treatment for patients with epilepsy who experience depressive symptoms., Comment: accepted in Epilepsy & Behavior on 02.11.23

Published
2023
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6. Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy: An Analysis of a Complex Comorbidity.

Author

Kanner, Andres, Saporta, Anita, Kim, Dong, Barry, John, Altalib, Hamada, Omotola, Hope, Jette, Nathalie, OBrien, Terence, Nadkarni, Siddhartha, Winawer, Melodie, Sperling, Michael, French, Jacqueline, Abou-Khalil, Bassel, Alldredge, Brian, Bebin, Martina, Cascino, Gregory, Cole, Andrew, Cook, Mark, Detyniecki, Kamil, Devinsky, Orrin, Dlugos, Dennis, Faught, Edward, Ficker, David, Fields, Madeline, Gidal, Barry, Gelfand, Michael, Glynn, Simon, Halford, Jonathan, Haut, Sheryl, Hegde, Manu, Holmes, Manisha, Kalviainen, Reetta, Kang, Joon, Klein, Pavel, Knowlton, Robert, Krishnamurthy, Kaarkuzhali, Kuzniecky, Ruben, Kwan, Patrick, Lowenstein, Daniel, Marcuse, Lara, Meador, Kimford, Mintzer, Scott, Pardoe, Heath, Park, Kristen, Penovich, Patricia, Singh, Rani, Somerville, Ernest, Szabo, Charles, Szaflarski, Jerzy, Lin Thio, K, Trinka, Eugen, and Burneo, Jorge

Subjects
Adult, Humans, Suicidal Ideation, Anxiety Disorders, Depressive Disorder, Major, Suicide, Comorbidity, Epilepsies, Partial, Risk Factors
Abstract

BACKGROUND AND OBJECTIVES: Mood, anxiety disorders, and suicidality are more frequent in people with epilepsy than in the general population. Yet, their prevalence and the types of mood and anxiety disorders associated with suicidality at the time of the epilepsy diagnosis are not established. We sought to answer these questions in patients with newly diagnosed focal epilepsy and to assess their association with suicidal ideation and attempts. METHODS: The data were derived from the Human Epilepsy Project study. A total of 347 consecutive adults aged 18-60 years with newly diagnosed focal epilepsy were enrolled within 4 months of starting treatment. The types of mood and anxiety disorders were identified with the Mini International Neuropsychiatric Interview, whereas suicidal ideation (lifetime, current, active, and passive) and suicidal attempts (lifetime and current) were established with the Columbia Suicidality Severity Rating Scale (CSSRS). Statistical analyses included the t test, χ2 statistics, and logistic regression analyses. RESULTS: A total of 151 (43.5%) patients had a psychiatric diagnosis; 134 (38.6%) met the criteria for a mood and/or anxiety disorder, and 75 (21.6%) reported suicidal ideation with or without attempts. Mood (23.6%) and anxiety (27.4%) disorders had comparable prevalence rates, whereas both disorders occurred together in 43 patients (12.4%). Major depressive disorders (MDDs) had a slightly higher prevalence than bipolar disorders (BPDs) (9.5% vs 6.9%, respectively). Explanatory variables of suicidality included MDD, BPD, panic disorders, and agoraphobia, with BPD and panic disorders being the strongest variables, particularly for active suicidal ideation and suicidal attempts. DISCUSSION: In patients with newly diagnosed focal epilepsy, the prevalence of mood, anxiety disorders, and suicidality is higher than in the general population and comparable to those of patients with established epilepsy. Their recognition at the time of the initial epilepsy evaluation is of the essence.

Published
2023

7. The platelet transcriptome and proteome in Alzheimers disease and aging: an exploratory cross-sectional study.

Author

de Sousa, Diana, Poupardin, Rodolphe, Villeda, Saul, Fröhlich, Thomas, Frey, Vanessa, Staffen, Wolfgang, Mrowetz, Heike, Altendorfer, Barbara, Unger, Michael, Iglseder, Bernhard, Paulweber, Bernhard, Trinka, Eugen, Cadamuro, Janne, Drerup, Martin, Schallmoser, Katharina, Aigner, Ludwig, Kniewallner, Kathrin, and Schroer, Adam

Subjects
Alzheimer’s disease, aging, platelets, proteomics, transcriptomics
Abstract

Introduction: Alzheimers disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood. Methods: To explore the molecular profile of AD and aged platelets, we investigated platelet activation (i.e., CD62P expression), proteome and transcriptome in AD patients, non-demented elderly, and young individuals as controls. Results: AD, aged and young individuals showed similar levels of platelet activation based on CD62P expression. However, AD and aged individuals had a proteomic signature suggestive of increased platelet activation compared with young controls. Transcriptomic profiling suggested the dysregulation of proteolytic machinery involved in regulating platelet function, particularly the ubiquitin-proteasome system in AD and autophagy in aging. The functional implication of these transcriptomic alterations remains unclear and requires further investigation. Discussion: Our data strengthen the evidence of enhanced platelet activation in aging and provide a first glimpse of the platelet transcriptomic changes occurring in AD.

Published
2023

17. Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Safdarian, Mahdi, Trinka, Eugen, Rahimi-Movaghar, Vafa, Thomschewski, Aljoscha, Aali, Amirali, Abady, Gdiom Gebreheat, Abate, Semagn Mekonnen, Abd-Allah, Foad, Abedi, Aidin, Adane, Denberu Eshetie, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmed, Haroon, Amanat, Nasir, Angappan, Dhanalakshmi, Arabloo, Jalal, Aryannejad, Armin, Athari, Seyyed Shamsadin, Atreya, Alok, Azadnajafabad, Sina, Azzam, Ahmed Y, Babamohamadi, Hassan, Banik, Palash Chandra, Bardhan, Mainak, Bashiri, Azadeh, Berhie, Alemshet Yirga, Bhat, Ajay Nagesh, Brown, Julie, Champs, Ana Paula, Charalampous, Periklis, Chukwu, Isaac Sunday, Coberly, Kaleb, Dadras, Omid, Yada, Dereje Y, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Dessalegn, Fikadu Nugusu, Desta, Abebaw Alemayehu, Dhingra, Sameer, Diao, Nancy, Diaz, Daniel, Dibas, Mahmoud, Dongarwar, Deepa, Dsouza, Haneil Larson, Ekholuenetale, Michael, El Nahas, Nevine, Elhadi, Muhammed, Eskandarieh, Sharareh, Fagbamigbe, Adeniyi Francis, Fares, Jawad, Fatehizadeh, Ali, Fereshtehnejad, Seyed-Mohammad, Fischer, Florian, Franklin, Richard Charles, Garg, Tushar, Getachew, Melaku, Ghaffarpasand, Fariborz, Gholamrezanezhad, Ali, Gholizadeh Mesgarha, Milad, Ghozy, Sherief, Golechha, Mahaveer, Goleij, Pouya, Graham, Simon Matthew, Gupta, Vivek Kumar, Haagsma, Juanita A., Hamidi, Samer, Harlianto, Netanja I., Harorani, Mehdi, Hasanian, Mohammad, Hassan, Amr, Hassen, Mohammed Bheser, Hoveidaei, Amir Human, Iravanpour, Farideh, Irilouzadian, Rana, Iwu, Chidozie C D, Jacob, Louis, Jaja, Chinwe Juliana, Joseph, Nitin, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Kadashetti, Vidya, Kandel, Amit, Kantar, Rami S., Karaye, Ibraheem M, Karkhah, Samad, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Md Jobair, Khayat Kashani, Hamid Reza, Khonji, Mohammad Saeid, Khormali, Moein, Kim, Grace, Krishnamoorthy, Vijay, Kumaran, Senthil D, Malekpour, Mohammad-Reza, Meretoja, Tuomo J, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Miller, Ted R, Mirahmadi, Alireza, Mirghaderi, Seyed Peyman, Mirza, Moonis, Misganaw, Awoke, Misra, Sanjeev, Mohammad, Yousef, Mohammadi, Esmaeil, Mokdad, Ali H, Möller, Holger, Momtazmanesh, Sara, Moni, Mohammad Ali, Mostafavi, Ebrahim, Mulita, Francesk, Naghavi, Mohsen, Nassereldine, Hasan, Natto, Zuhair S, Nejati, Kazem, Nguyen, Huong Lan Thi, Nguyen, Van Thanh, Nogueira de Sá, Antonio Tolentino, Olagunju, Andrew T, Olufadewa, Isaac Iyinoluwa, Omotayo, Abiodun Olusola, Owolabi, Mayowa O, Patil, Shankargouda, Pawar, Shrikant, Pedersini, Paolo, Petcu, Ionela-Roxana, Polinder, Suzanne, Pourbagher-Shahri, Ali Mohammad, Qureshi, Maryam Faiz, Raghav, Pankaja Raghav, Rahman, Mosiur, Rahnavard, Niloufar, Rajabpour-Sanati, Ali, Rashidi, Mohammad-Mahdi, Rawaf, Salman, Roberts, Nicholas L S, Saddik, Basema, Saeed, Umar, Samadzadeh, Sara, Samy, Abdallah M, Sarveazad, Arash, Seylani, Allen, Shafie, Mahan, Shahbandi, Ataollah, Sharew, Mequannent Melaku Sharew, Sheikhi, Rahim Ali, Shetty, Pavanchand H, Yigit, Arzu, Shobeiri, Parnian, Shool, Sina, Shorofi, Seyed Afshin, Sibhat, Migbar Mekonnen, Sinaei, Ehsan, Singh, Paramdeep, Singh, Surjit, Solomon, Yonatan, Sotoudeh, Houman, Tadesse, Belsti Atnkut, Umair, Muhammad, Valadan Tahbaz, Sahel, Valdez, Pascual R, Venketasubramanian, Narayanaswamy, Vu, Linh Gia, Wickramasinghe, Nuwan Darshana, Zare, Iman, Yazdanpanah, Fereshteh, Wu, Ai-Min, and Zhang, Zhi-Jiang

Published
2023
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18. A global survey on the attitudes of neurologists and psychiatrists about functional/psychogenic/dissociative/nonepileptic-seizures/attacks, in the search of its name

Author

Asadi-Pooya, Ali A., Brigo, Francesco, Trinka, Eugen, Lattanzi, Simona, Adel Kishk, Nirmeen, Karakis, Ioannis, Ristic, Aleksandar J., Alsaadi, Taoufik, Alkhaldi, Modhi, Turuspekova, Saule T., Aljandeel, Ghaieb, Al-Asmi, Abdullah, Contreras, Guilca, Daza-Restrepo, Anilu, Kutlubaev, Mansur A., Guekht, Alla, Calle-López, Yamile, Jusupova, Asel, San-juan, Daniel, Khachatryan, Samson G., Gigineishvili, David, Mesraoua, Boulenouar, Dubenko, Andriy, and Mirzaei Damabi, Nafiseh

Published
2023
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22. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

Author

Chamberlain, James M, Kapur, Jaideep, Shinnar, Shlomo, Elm, Jordan, Holsti, Maija, Babcock, Lynn, Rogers, Alex, Barsan, William, Cloyd, James, Lowenstein, Daniel, Bleck, Thomas P, Conwit, Robin, Meinzer, Caitlyn, Cock, Hannah, Fountain, Nathan B, Underwood, Ellen, Connor, Jason T, Silbergleit, Robert, Gray, Emily, Gunter, Sonya, Fansler, Amy, Stevenson, Valerie, Bengelink, Erin, Harney, Deneil, Speers, Mickie, Black, Joy, Fisher, Natalie, Harsh, Donna, Ramakrishnan, Arthi, Harris, Lindsey, Bozeman, Nia, Spiteri, Aimee, Palesch, Yuko, Tillman, Holly, Zhao, Wenle, Pauls, Qi, Arnaud, Chris, Dillon, Catherine R, Riley, Jodie, Alford, Teldon, Conner, Cassidy, Coles, Lisa, Sathe, Abhi, Janis, Scott, Hartman, Adam, Fureman, Brandy, Trinka, Eugen, Treiman, David, Wright, David, Ratcliff, Jonathan, Hall, Alex, Williams, Alaina, Simon, Harold, Stanley, Nicholas, Humphries, Roger, Mims, Theresa, Short, Joann, Jones, Elizabeth, Ottman, Misty, Gentile, Nina, Isenberg, Derek, Reimer, Hannah, Kalugdan, Vernon Sayoc, Hemphill, Claude, Madhok, Debbie Yi, Duncan, Jeany, Randazzo, Dominica, Quinn, James, Visweswaran, Anita, Mann, Rosen, Adeoye, Opeolu, McMullan, Jason, Foreman, Brandon, Keegan, Sara, Biros, Michelle, Driver, Brian, Hendrickson, Audrey, Stang, Jamie, Lewandowski, Christopher, Miller, Joseph, Chaudhry, Kaleem, Berry, Shannen, Warden, Craig, Blake, Rachel, Cook, Jennifer NB, Sabolick, Erin, Selman, Antoine, Kissman, Katrina, Moore, Monica, Huff, J Stephen, Becker, Lea, Claassen, Jan, Velazquez, Angela, Falo, Cristina, Coralic, Zlatan, Grupp-Phelan, Jackie, Baren, Jill, Ellison, Angela, Woodford, Ashley, and Samba, Ima

Subjects
Neurodegenerative, Epilepsy, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Neurosciences, Pediatric, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Anticonvulsants, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Infant, Levetiracetam, Male, Middle Aged, Phenytoin, Status Epilepticus, Valproic Acid, Young Adult, Neurological Emergencies Treatment Trials, Pediatric Emergency Care Applied Research Network investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundBenzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in children to compare outcomes in three age groups.MethodsIn this multicentre, double-blind, response-adaptive, randomised controlled trial, we recruited patients from 58 hospital emergency departments across the USA. Patients were eligible for inclusion if they were aged 2 years or older, had been treated for a generalised convulsive seizure of longer than 5 min duration with adequate doses of benzodiazepines, and continued to have persistent or recurrent convulsions in the emergency department for at least 5 min and no more than 30 min after the last dose of benzodiazepine. Patients were randomly assigned in a response-adaptive manner, using Bayesian methods and stratified by age group (65 years), to levetiracetam, fosphenytoin, or valproate. All patients, investigators, study staff, and pharmacists were masked to treatment allocation. The primary outcome was absence of clinically apparent seizures with improved consciousness and without additional antiseizure medication at 1 h from start of drug infusion. The primary safety outcome was life-threatening hypotension or cardiac arrhythmia. The efficacy and safety outcomes were analysed by intention to treat. This study is registered in ClinicalTrials.gov, NCT01960075.FindingsBetween Nov 3, 2015, and Dec 29, 2018, we enrolled 478 patients and 462 unique patients were included: 225 children (aged 65 years). 175 (38%) patients were randomly assigned to levetiracetam, 142 (31%) to fosphenyltoin, and 145 (31%) were to valproate. Baseline characteristics were balanced across treatments within age groups. The primary efficacy outcome was met in those treated with levetiracetam for 52% (95% credible interval 41-62) of children, 44% (33-55) of adults, and 37% (19-59) of older adults; with fosphenytoin in 49% (38-61) of children, 46% (34-59) of adults, and 35% (17-59) of older adults; and with valproate in 52% (41-63) of children, 46% (34-58) of adults, and 47% (25-70) of older adults. No differences were detected in efficacy or primary safety outcome by drug within each age group. With the exception of endotracheal intubation in children, secondary safety outcomes did not significantly differ by drug within each age group.InterpretationChildren, adults, and older adults with established status epilepticus respond similarly to levetiracetam, fosphenytoin, and valproate, with treatment success in approximately half of patients. Any of the three drugs can be considered as a potential first-choice, second-line drug for benzodiazepine-refractory status epilepticus.FundingNational Institute of Neurological Disorders and Stroke, National Institutes of Health.

Published
2020

23. Telemedicine for Individuals with epilepsy: Recommendations from the International League Against Epilepsy Telemedicine Task Force

Author

Samia, Pauline, Sahu, Jitendra Kumar, Ali, Amza, Caraballo, Roberto Horacio, Chan, Josephine, Coan, Ana Carolina, Fortini, Pablo Sebastián, Gwer, Samson, Jocic-Jakubi, Bosanka, Kissani, Najib, Rivera, Yanin, Sarfo, Fred Stephen, Singh, Mamta Bhushan, Trinka, Eugen, Yoo, Ji Yeoun, Yu, Hsiang-Yu, Zelano, Johan, and Cross, J.Helen

Published
2023
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27. FRI-303 Depression as a determinant of metabolic dysfunction-associated steatotic liver disease (MASLD) risk in the Paracelsus 10, 000 study

Author

Koutny, Florian, primary, Aigner, Elmar, additional, Datz, Christian, additional, Gensluckner, Sophie, additional, Maieron, Andreas, additional, Mega, Andrea, additional, Iglseder, Bernhard, additional, Langthaler, Patrick, additional, Flamm, Maria, additional, Frey, Vanessa, additional, Paulweber, Bernhard, additional, Trinka, Eugen, additional, and Wernly, Bernhard, additional

Published
2024
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28. Aberrant Auditory Prediction Patterns Robustly Characterize Tinnitus

Author

Reisinger, Lisa, primary, Demarchi, Gianpaolo, additional, Obleser, Jonas, additional, Sedley, William, additional, Partyka, Marta, additional, Schubert, Juliane, additional, Gehmacher, Quirin, additional, Roesch, Sebastian, additional, Suess, Nina, additional, Trinka, Eugen, additional, Schlee, Winfried, additional, and Weisz, Nathan, additional

Published
2024
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33. Expert Consensus Recommendations on Seizure Emergencies Suitable for Rapid and Early Seizure Termination (REST) and Timing of Intervention (P9-1.003)

Author

Pina-Garza, Jesus Eric, primary, Chez, Michael, additional, Cloyd, James, additional, Hirsch, Lawrence J., additional, Kalviainen, Reetta, additional, Klein, Pavel, additional, Lagae, Lieven, additional, Sankar, Raman, additional, Specchio, Nicola, additional, Strzelczyk, Adam, additional, Toledo, Manuel, additional, and Trinka, Eugen, additional

Published
2024
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34. It’s About Time! Timing in Epilepsy Evaluation and Treatment

Author

McKee, Heather Ravvin, primary, Vidaurre, Jorge, additional, Clarke, Dave, additional, Wagner, Janelle, additional, W. Britton, Jeffrey, additional, Laux, Linda, additional, Trinka, Eugen, additional, Rubinos, Clio, additional, McDonald, Tanya J. W., additional, Lado, Fred A., additional, Bebin, Martina, additional, Papadelis, Christos, additional, Struck, Aaron F., additional, Maciel, Carolina B., additional, Velasco, Ana L., additional, Chandran, Arjun, additional, Pati, Sandipan, additional, Tandon, Nitin, additional, Vaca, Guadalupe Fernandez-Baca, additional, Berl, Madison M., additional, and Moosa, Ahsan N., additional

Published
2024
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37. Physicians’ beliefs about brain surgery for drug-resistant epilepsy: A global survey

Author

Asadi-Pooya, Ali A., Brigo, Francesco, Trinka, Eugen, Lattanzi, Simona, Karakis, Ioannis, Kishk, Nirmeen Adel, Valente, Kette D., Jusupova, Asel, Turuspekova, Saule T., Daza-Restrepo, Anilu, Contreras, Guilca, Kutlubaev, Mansur A., Guekht, Alla, Rahimi-Jaberi, Abbas, Aljandeel, Ghaieb, Calle-Lopez, Yamile, Alsaadi, Taoufik, Ashkanani, Abdulaziz, Ranganathan, Lakshmi Narasimhan, Al-Asmi, Abdullah, Khachatryan, Samson G., Gigineishvili, David, Mesraoua, Boulenouar, and Mwendaweli, Naluca

Published
2022
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38. Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis

Author

Stevelink, Remi, Al-Toma, Dania, Jansen, Floor E., Lamberink, Herm J., Asadi-Pooya, Ali A., Farazdaghi, Mohsen, Cação, Gonçalo, Jayalakshmi, Sita, Patil, Anuja, Özkara, Çiğdem, Aydın, Şenay, Gesche, Joanna, Beier, Christoph P., Stephen, Linda J., Brodie, Martin J., Unnithan, Gopeekrishnan, Radhakrishnan, Ashalatha, Höfler, Julia, Trinka, Eugen, Krause, Roland, Irelli, Emanuele Cerulli, Di Bonaventura, Carlo, Szaflarski, Jerzy P., Hernández-Vanegas, Laura E., Moya-Alfaro, Monica L., Zhang, Yingying, Zhou, Dong, Pietrafusa, Nicola, Specchio, Nicola, Japaridze, Giorgi, Beniczky, Sándor, Janmohamed, Mubeen, Kwan, Patrick, Syvertsen, Marte, Selmer, Kaja K., Vorderwülbecke, Bernd J., Holtkamp, Martin, Viswanathan, Lakshminarayanapuram G., Sinha, Sanjib, Baykan, Betül, Altindag, Ebru, von Podewils, Felix, Schulz, Juliane, Seneviratne, Udaya, Viloria-Alebesque, Alejandro, Karakis, Ioannis, D'Souza, Wendyl J., Sander, Josemir W., Koeleman, Bobby P.C., Otte, Willem M., and Braun, Kees P.J.

Published
2022
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42. Protocol for the development of an international Core Outcome Set for treatment trials in adults with epilepsy: the EPilepsy outcome Set for Effectiveness Trials Project (EPSET)

Author

Mitchell, James W., Noble, Adam, Baker, Gus, Batchelor, Rachel, Brigo, Francesco, Christensen, Jakob, French, Jacqueline, Gil-Nagel, Antonio, Guekht, Alla, Jette, Nathalie, Kälviäinen, Reetta, Leach, John Paul, Maguire, Melissa, O’Brien, Terence, Rosenow, Felix, Ryvlin, Philippe, Tittensor, Phil, Tripathi, Manjari, Trinka, Eugen, Wiebe, Samuel, Williamson, Paula R., and Marson, Tony

Published
2022
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44. Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy: An Analysis of a Complex Comorbidity

Author

Kanner, Andres M., Saporta, Anita S, Kim, Dong H, Barry, John J, Altalib, Hamada, Omotola, Hope, Jette, Nathalie, OʼBrien, Terence J., Nadkarni, Siddhartha, Winawer, Melodie R., Sperling, Michael, French, Jacqueline A, Abou-Khalil, Bassel, Alldredge, Brian, Bebin, Martina, Cascino, Gregory D, Cole, Andrew J., Cook, Mark J., Detyniecki, Kamil, Devinsky, Orrin, Dlugos, Dennis, Faught, Edward, Ficker, David, Fields, Madeline, Gidal, Barry, Gelfand, Michael, Glynn, Simon, Halford, Jonathan J., Haut, Sheryl, Hegde, Manu, Holmes, Manisha G., Kalviainen, Reetta, Kang, Joon, Klein, Pavel, Knowlton, Robert C, Krishnamurthy, Kaarkuzhali, Kuzniecky, Ruben, Kwan, Patrick, Lowenstein, Daniel H., Marcuse, Lara, Meador, Kimford J., Mintzer, Scott, Pardoe, Heath R, Park, Kristen, Penovich, Patricia, Singh, Rani K, Somerville, Ernest, Szabo, Charles A, Szaflarski, Jerzy P., Lin Thio, K. Liu, Trinka, Eugen, and Burneo, Jorge G

Published
2022
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46. Counseling about sudden unexpected death in epilepsy (SUDEP): A global survey of neurologists’ opinions

Author

Asadi-Pooya, Ali A., Trinka, Eugen, Brigo, Francesco, Hingray, Coraline, Karakis, Ioannis, Lattanzi, Simona, Valente, Kette D., Contreras, Guilca, Turuspekova, Saule T., Kishk, Nirmeen Adel, Aljandeel, Ghaieb, Farazdaghi, Mohsen, Lopez, Yamile Calle, Kissani, Najib, Triki, Chahnez, Krämer, Günter, Surges, Rainer, Mesraoua, Boulenouar, Yu, Hsiang-Yu, Daza-Restrepo, Anilu, Alsaadi, Taoufik, Al-Asmi, Abdullah, Kutlubaev, Mansur A., Pretorius, Chrisma, Jusupova, Asel, Khachatryan, Samson G., Ranganathan, Lakshmi Narasimhan, Ashkanani, Abdulaziz, Tomson, Torbjörn, and Gigineishvili, David

Published
2022
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48. Vaccination and childhood epilepsies

Author

Craiu, Dana, Rener Primec, Zvonka, Lagae, Lieven, Vigevano, Federico, Trinka, Eugen, Specchio, Nicola, Bakhtadze, Sophia, Cazacu, Cristina, Golli, Tanja, and Zuberi, Sameer M.

Published
2022
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49. Investigating the Added Value of Beck's Depression Inventory in Atherosclerosis Prediction: Lessons from Paracelsus 10,000.

Author

Dienhart, Christiane, Aigner, Elmar, Iglseder, Bernhard, Frey, Vanessa, Gostner, Isabella, Langthaler, Patrick, Paulweber, Bernhard, Trinka, Eugen, and Wernly, Bernhard

Subjects
MENTAL illness, CAROTID artery ultrasonography, CARDIOVASCULAR diseases, BECK Depression Inventory, CEREBROVASCULAR disease, ATHEROSCLEROTIC plaque
Abstract

Background: Depression is the most common mental illness worldwide and generates an enormous health and economic burden. Furthermore, it is known to be associated with an elevated risk of arteriosclerotic cardiovascular diseases (ASCVD), particularly stroke. However, it is not a factor reflected in many ASCVD risk models, including SCORE2. Thus, we analysed the relationship between depression, ASCVD and SCORE2 in our cohort. Methods: We analysed 9350 subjects from the Paracelsus 10,000 cohort, who underwent both a carotid artery ultrasound and completed a Beck Depression Inventory (BDI) screening. Patients were categorised binomially based on the BDI score. Atherosclerotic carotid plaque or absence was dichotomised for logistic regression modelling. Odds ratios and adjusted relative risks were calculated using Stata. Results: Subjects with an elevated BDI (≥14) had higher odds for carotid plaques compared to subjects with normal BDI, especially after adjusting for classical risk factors included in SCORE2 (1.21; 95%CI 1.03–1.43, p = 0.023). The adjusted relative risk for plaques was also increased (1.09; 95%CI 1.01–1.18, p = 0.021). Subgroup analysis showed an increased odds of plaques with increases in depressive symptoms, particularly in women and patients ≤55 yrs. Conclusions: In our cohort, the BDI score is associated with subclinical atherosclerosis beyond classical risk factors. Thus, depression might be an independent risk factor which may improve risk stratification if considered in ASCVD risk prediction models, such as SCORE2. Furthermore, reminding clinicians to take mental health into consideration to identify individuals at increased atherosclerosis risk may provide added opportunities to address measures which can reduce the risk of ASCVD. [ABSTRACT FROM AUTHOR]

Published
2024
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