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2 results on '"Trinidad Israel"'

1. Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients

Author

Laia Fernández-Barat, Ana Motos, Mauro Panigada, Francisco Álvarez-Lerma, Lucía Viña, Ruben Lopez-Aladid, Adrian Ceccato, Gianluigi Li Bassi, David P. Nicolau, Yuli Lopez, Laura Muñoz, Laura Guerrero, Dolors Soy, Trinidad Israel, Pedro Castro, and Antoni Torres

Subjects
Endotracheal tube, Biofilm, Methicillin-resistant Staphylococcus aureus, Linezolid, Vancomycin, Respiratory infection, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Purpose To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT cuff from orotracheally intubated patients with MRSA respiratory infection. Methods Prospective observational clinical study was carried out at four European tertiary hospitals. Plasma and endotracheal aspirate (ETA) levels of LNZ and VAN were determined 72 h after treatment initiation through high-performance liquid chromatography or bioassay. LNZ or VAN concentration in the ETT biofilm and MRSA burden and eradication was determined upon extubation. The minimum inhibitory concentration (MIC) for LNZ and VAN was assessed by E-test strips (Biomerieux®). Scanning electron microscopy images were obtained, and ETT biofilm thickness was compared between groups. Results Twenty-five patients, 15 treated with LNZ and 10 with VAN, were included in the study. LNZ presented a significantly higher concentration (μg/mL) than VAN in ETT biofilm (72.8 [1.3–127.1] vs 0.4 [0.4–1.3], p

Published
2019
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2. Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients

Author

Yuli Lopez, Laura Guerrero, Pedro Castro, Trinidad Israel, Ana Motos, Laia Fernández-Barat, Antoni Torres, L. Viña, Gianluigi Li Bassi, Francisco Álvarez-Lerma, Mauro Panigada, David P. Nicolau, Laura Muñoz, Dolors Soy, Rubén López-Aladid, and Adrian Ceccato

Subjects
Male, Respiratory diseases, Organ Dysfunction Scores, Critical Care and Intensive Care Medicine, medicine.disease_cause, Infeccions respiratòries, Malalties de l'aparell respiratori, chemistry.chemical_compound, Minimum inhibitory concentration, Vancomycin, Respiratory infection, Intubation, Intratracheal, Medicine, Humans, Prospective Studies, APACHE, Aged, Analysis of Variance, business.industry, Research, Biofilm, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Linezolid, Microbiologia mèdica, Respiratory infections, lcsh:RC86-88.9, Middle Aged, biochemical phenomena, metabolism, and nutrition, Medical microbiology, Endotracheal tube, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Virus, Intensive Care Units, chemistry, Staphylococcus aureus, Anesthesia, Biofilms, Cuff, Viruses, Microscopy, Electron, Scanning, Female, business, medicine.drug
Abstract

Purpose To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT cuff from orotracheally intubated patients with MRSA respiratory infection. Methods Prospective observational clinical study was carried out at four European tertiary hospitals. Plasma and endotracheal aspirate (ETA) levels of LNZ and VAN were determined 72 h after treatment initiation through high-performance liquid chromatography or bioassay. LNZ or VAN concentration in the ETT biofilm and MRSA burden and eradication was determined upon extubation. The minimum inhibitory concentration (MIC) for LNZ and VAN was assessed by E-test strips (Biomerieux®). Scanning electron microscopy images were obtained, and ETT biofilm thickness was compared between groups. Results Twenty-five patients, 15 treated with LNZ and 10 with VAN, were included in the study. LNZ presented a significantly higher concentration (μg/mL) than VAN in ETT biofilm (72.8 [1.3–127.1] vs 0.4 [0.4–1.3], p

Published
2019

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