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2. The polyphenolic compound punicalagin protects skin fibroblasts from UVA radiation oxidative damage

Author

Bianchetti, Giada, Bottoni, Paola, Tringali, Giuseppe, Maulucci, Giuseppe, Tabolacci, Elisabetta, Clementi, Maria Elisabetta, Bianchetti G. (ORCID:0000-0003-1257-2295), Bottoni P., Tringali G. (ORCID:0000-0002-1030-9429), Maulucci G. (ORCID:0000-0002-2154-319X), Tabolacci E. (ORCID:0000-0002-4707-2242), Clementi M. E., Bianchetti, Giada, Bottoni, Paola, Tringali, Giuseppe, Maulucci, Giuseppe, Tabolacci, Elisabetta, Clementi, Maria Elisabetta, Bianchetti G. (ORCID:0000-0003-1257-2295), Bottoni P., Tringali G. (ORCID:0000-0002-1030-9429), Maulucci G. (ORCID:0000-0002-2154-319X), Tabolacci E. (ORCID:0000-0002-4707-2242), and Clementi M. E.

Abstract

Polyphenols are a class of natural compounds that act as antioxidants, neutralising harmful free radicals that would damage cells and increase the risk of diseases such as cancer, diabetes and heart disease. They also reduce inflammation, which is thought to be at the root of many chronic diseases. We are investigating the photoprotective effects of punicalagin, a type of polyphenolic compound mainly found in pomegranates, against UVA-induced damage in human skin fibroblasts. Punicalagin increases cell viability and reduces the high levels of ROS generated by photooxidative stress through its ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 pathway results in an increase in reduced glutathione, NADH, and subsequently protects mitochondrial respiratory capacity. Integrating molecular and imaging approaches, our results demonstrate a potential cytoprotective effect of punicalagin against UVA-induced skin damage through an anti-apoptotic mechanism.

Published
2024

10. Prediction of basal metabolic rate in patients with Prader-Willi syndrome

Author

Lazzer, S., Grugni, G., Tringali, G., and Sartorio, A.

Subjects
Physiological aspects, Health aspects, Basal metabolism -- Health aspects, Prader-Willi syndrome -- Physiological aspects
Abstract

INTRODUCTION Prader-Willi syndrome (PWS) is a rare disorder (incidence 1/150001/30000), generally sporadic, characterized by a recognisable pattern of dysmorphic features and neurologic, cognitive, endocrine and behavioural disturbances. (1) PWS was [...], BACKGROUND/OBJECTIVES: The objective of this study was to develop new equations for predicting basal metabolic rate (BMR) in Prader-Willi syndrome (PWS) subjects and to compare their accuracy with commonly used equations developed by Lazzer (2007), Livingston (2005), Huang (2004), Nelson (1992), Mifflin (1990), Owen (1987), WHO (1985), Bernstein (1983) and Harris-Benedict (1919), using the Bland-Altman method. SUBJECTS /METHODS: BMR was measured by indirect calorimetry and fat-free mass (FFM) and fat mass (FM) by a tetrapolar impedancemeter in 80 Caucasian PWS patients (mean body mass index: 39.1 kg/[m.sup.2]; 17-50 years). Equations were derived by stepwise multiple regression analysis using a calibration group (n:50) and tested against the validation group (n:30). RESULTS: Two new equations, based on anthropometric (BMR = body mass x0.052+sexx 0.778-age x 0.033+2.839 ([R.sup.2.sub.adj] = 0.61, s.e. = 0.89MJ per day)) or body composition (BMR = FFMx0.074+FMx0.042+sexx0.636-agex0.037+2.515 ([R.sup.2.sub.adj] = 0.69, s.e. = 0.82 MJ per day)), were generated. Predicted BMR (PBMR) was not significantly different from the measured BMR (< 3.3%), and was accurate in 59% and 62% of patients, respectively. Nevertheless, significant magnitude bias was found for both equations (P < 0.001, [R.sup.2] = 0.36). The Owen (1987), Mifflin (1990), Huang (2004) and Lazzer (2007) equations showed mean differences < 5% and PBMR was accurate in ~50% of patients. The Livingston (2005), WHO (1985) and Harris-Benedict (1919) equations showed a PBMR overestimation >7% and were accurate in < 50% of patients. The Nelson (1992) and Bernstein (1983) equations showed a greater PBMR underestimation in >60% of subjects. CONCLUSIONS: The new prediction equations showed significantly higher accuracy compared with equations tested, with exception of Lazzer (2007) and Livingston (2005) equations, and result in lower mean differences and lower limits of agreement compared with the equations tested. European Journal of Clinical Nutrition (2016) 70, 494-498; doi: 10.1038/ejcn.2015.161; published online 23 September 2015

Published
2016
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15. Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress Induced by Hydrogen Peroxide

Author

Clementi, Maria Elisabetta, Pizzoferrato, Michela, Bianchetti, Giada, Brancato, A., Sampaolese, B., Maulucci, Giuseppe, Tringali, Giuseppe, Clementi M. E., Pizzoferrato M., Bianchetti G. (ORCID:0000-0003-1257-2295), Maulucci G. (ORCID:0000-0002-2154-319X), Tringali G. (ORCID:0000-0002-1030-9429), Clementi, Maria Elisabetta, Pizzoferrato, Michela, Bianchetti, Giada, Brancato, A., Sampaolese, B., Maulucci, Giuseppe, Tringali, Giuseppe, Clementi M. E., Pizzoferrato M., Bianchetti G. (ORCID:0000-0003-1257-2295), Maulucci G. (ORCID:0000-0002-2154-319X), and Tringali G. (ORCID:0000-0002-1030-9429)

Published
2022

16. Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene

Author

Marei, H. E., Althani, A., Afifi, N., Hasan, A., Caceci, T., Felsani, A., Tringali, Giuseppe, Cifola, I., Pozzoli, Giacomo, Cenciarelli, C., Tringali G. (ORCID:0000-0002-1030-9429), Pozzoli G. (ORCID:0000-0003-0398-7026), Marei, H. E., Althani, A., Afifi, N., Hasan, A., Caceci, T., Felsani, A., Tringali, Giuseppe, Cifola, I., Pozzoli, Giacomo, Cenciarelli, C., Tringali G. (ORCID:0000-0002-1030-9429), and Pozzoli G. (ORCID:0000-0003-0398-7026)

Abstract

Background: Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem cells (CSC) which confer resistance against standard chemo- and radiotherapeutics modalities. Two types of GBM-associated CSC were isolated from the same patient: tumor core- (c-CSC) and peritumor tissue-derived cancer stem cells (p-CSC). Our experiments are focused on glioblastoma–IDH-wild type, and no disease-defining alterations were present in histone, BRAF or other genes. Methods: In the present study, potential differences in genetic variants between c-CSC versus p-CSC derived from four GBM patients were investigated with the aims of (1) comparing the exome sequences between all the c-CSC or p-CSC to identify the common variants; (2) identifying the variants affecting the function of genes known to be involved in cancer origin and development. Results: By comparative analyses, we identified common gene single nucleotide variants (SNV) in all GBM c-CSC and p-CSC, a potentially deleterious variant was a frameshift deletion at Gln461fs in the MLLT1 gene, that was encountered only in p-CSC samples with different allelic frequency. Conclusions: We discovered a potentially harmful frameshift deletion at Gln461fs in the MLLT1 gene. Further investigation is required to confirm the presence of the identified mutations in patient tissue samples, as well as the significance of the frameshift mutation in the MLLT1 gene on GBM biology and response to therapy based on genomic functional experiments.

Published
2022

25. Cytoprotective effects of punicalagin on hydrogen–peroxide–mediated oxidative stress and mitochondrial dysfunction in retinal pigment epithelium cells

Author

Clementi, Maria Elisabetta, Maulucci, Giuseppe, Bianchetti, Giada, Pizzoferrato, Michela, Sampaolese, B., Tringali, Giuseppe, Clementi M. E., Maulucci G. (ORCID:0000-0002-2154-319X), Bianchetti G. (ORCID:0000-0003-1257-2295), Pizzoferrato M., Tringali G. (ORCID:0000-0002-1030-9429), Clementi, Maria Elisabetta, Maulucci, Giuseppe, Bianchetti, Giada, Pizzoferrato, Michela, Sampaolese, B., Tringali, Giuseppe, Clementi M. E., Maulucci G. (ORCID:0000-0002-2154-319X), Bianchetti G. (ORCID:0000-0003-1257-2295), Pizzoferrato M., and Tringali G. (ORCID:0000-0002-1030-9429)

Published
2021

26. Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity ... and return

Author

Brancato, A., Castelli, Vilma, Lavanco, G., Tringali, Giuseppe, Micale, V., Kuchar, M., D'Amico, C., Pizzolanti, G., Feo, S., Cannizzaro, Maria Chiara, Castelli V., Tringali G. (ORCID:0000-0002-1030-9429), Cannizzaro C., Brancato, A., Castelli, Vilma, Lavanco, G., Tringali, Giuseppe, Micale, V., Kuchar, M., D'Amico, C., Pizzolanti, G., Feo, S., Cannizzaro, Maria Chiara, Castelli V., Tringali G. (ORCID:0000-0002-1030-9429), and Cannizzaro C.

Abstract

Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress; (2) stress-axis functionality; and (3) dopaminergic and glutamatergic neuroadaptation in the NAc. We also assess the potential effects of the non-intoxicating phytocannabinoid cannabidiol, to counteract (or reverse) the development of detrimental consequences of binge-like alcohol exposure. Our results show that adolescent binge-like alcohol exposure alters the sensitivity to positive stimuli, exerts social and novelty-triggered anxiety-like behaviour, and passive stress-coping during early and prolonged withdrawal. In addition, serum corticosterone and hypothalamic and NAc corticotropin-releasing hormone levels progressively increase during withdrawal. Besides, NAc tyrosine hydroxylase levels increase at late withdrawal, while the expression of dopamine transporter, D1 and D2 receptors is dynamically altered during binge and withdrawal. Furthermore, the expression of markers of excitatory postsynaptic signaling—PSD95; Homer-1 and-2 and the activity-regulated spine-morphing proteins Arc, LIM Kinase 1 and FOXP1—increase at late withdrawal. Notably, subchronic cannabidiol, during withdrawal, attenuates social-and novelty-induced aversion and passive stress-coping and rectifies the hyper-responsive stress axis and NAc dopamine and glutamate-related neuroplasticity. Overall, the exposure to binge-like alcohol levels in adolescent rats makes the NAc, during withdrawal, a locus minoris resistentiae as a result of perturbations in neuroplasticity and in stress-axis homeostasis. Cannabidiol holds a promising potential for increasing behavioural, neuroendocrine and molecular resilience against binge-like alcohol harmful

Published
2021

27. POS1406 DEVELOPMENT OF A DIAGNOSTIC ALGORITHM FOR THE DIFFERENTIAL DIAGNOSIS OF INTERSTITIAL LUNG DISEASE: PRELIMINARY DATA FROM A MULTICENTER RETROSPECTIVE CASE-CONTROL STUDY

Author

Maranini, B., primary, Chiodin, T., additional, Scirè, C. A., additional, Govoni, M., additional, Lucioni, E., additional, Chiarello, S., additional, Scabbia, F., additional, Marchi, I., additional, Zanframundo, G., additional, Cavagna, L., additional, Bellis, E., additional, Silva, M., additional, Tringali, G., additional, and Carnevale, A., additional

Published
2021
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33. Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage by activating nrf2/ho-1 signaling pathway and reducing apoptosis

Author

Clementi, Maria Elisabetta, Sampaolese, B., Sciandra, Francesca, Tringali, Giuseppe, Clementi M. E., Sciandra F., Tringali G. (ORCID:0000-0002-1030-9429), Clementi, Maria Elisabetta, Sampaolese, B., Sciandra, Francesca, Tringali, Giuseppe, Clementi M. E., Sciandra F., and Tringali G. (ORCID:0000-0002-1030-9429)

Abstract

The oxidative damage of the retinal pigment epithelium (RPE) is the early event that underlies the pathogenesis of maculopathies. Numerous studies have shown that punicalagin (PUN), a polyphenol present in pomegranate, can protect several cell types from oxidative stress. Our study aims to establish if PUN protects RPE from UV radiation-induced oxidative damage. We used an experimental model which involves the use of a human-RPE cell line (ARPE-19) exposed to UV-A radiation for 1, 3, and 5 hours. ARPE-19 cells were pre-treated with PUN (24 h) followed by UV-A irradiation; controls were treated identically, except for UV-A. Effects of pre-treatment with PUN on cell viability, intracellular reactive oxygen species ROS levels, modulation of Nrf2 and its antioxidant target genes, and finally apoptosis were examined. We found that pre-treatment with PUN: (1) antagonized the decrease in cell viability and reduced high levels of ROS associated with UV-A-induced oxidative stress; (2) activated Nrf2 signaling pathway by promoting Nrf2 nuclear translocation and upregulating its downstream antioxidant target genes (HO-1 and NQO1); (3) induced an anti-apoptotic effect by decreasing Bax/Bcl-2 ratio. These findings provide the first evidence that PUN can prevent UV-A-induced oxidative damage in RPE, offering itself as a possible antioxidant agent capable of contrasting degenerative eye diseases.

Published
2020

34. A proof-of-concept study on CGRP plasma levels of migraineurs during a 6-month treatment with ERENUMAB

Author

Tringali, Giuseppe, Vollono, Catello, Calabresi, Paolo, Navarra, Pierluigi, Tringali G. (ORCID:0000-0002-1030-9429), Vollono C., Calabresi P. (ORCID:0000-0003-0326-5509), Navarra P. (ORCID:0000-0002-4424-650X), Tringali, Giuseppe, Vollono, Catello, Calabresi, Paolo, Navarra, Pierluigi, Tringali G. (ORCID:0000-0002-1030-9429), Vollono C., Calabresi P. (ORCID:0000-0003-0326-5509), and Navarra P. (ORCID:0000-0002-4424-650X)

Abstract

The introduction of monoclonal antibodies (mAbs) against calcitonin-gene related peptide (CGRP) or CGRP receptors in the treatment of migraine raised concerns on the possible risks associated to the long-term inhibition of CGRP physiological functions. In this proof-of-concept study, we have measured the circulating levels of CGRP in 7 patients with high-frequency episodic migraine receiving the anti-CGRP receptor mAb erenumab for at least 6 months, to test the hypothesis that long-term blockade of CGRP receptors induces an increase in systemic CGRP levels via a classical up-regulation mechanism. Plasma CGRP levels were measured by a validated radioimmunoassay at baseline, and after 1 and 6 months of treatment with erenumab, 70 mg given sc every 4 weeks. We found (data expressed as the means ± SD): 38.34 ± 30.74 pg CGRP/ml of plasma at baseline, 38.19 ± 29.23 pg/ml after 1 month and 53.89 ± 28.03 pg/ml after 6 months of treatment. Thus, the average increase in plasma CGRP levels after 6 months of treatment was about + 40% compared to both baseline and 1-month treatments; such difference was not statistically significant because of high SD values in all groups. These preliminary findings need to be confirmed in larger, sufficiently powered experiments.

Published
2020

37. Low-latency Gravitational-wave Alerts for Multimessenger Astronomy during the Second Advanced LIGO and Virgo Observing Run

Author

Abbott, (Abbott, Bp, Abbott, B. P., (Abbott, R, Abbott, R., (Abbott, Td, Abraham, T. D., (Abraham, S, Acernese, S., (Acernese, F, Ackley, F., (Ackley, K, Adams, K., (Adams, C, Adhikari, C., (Adhikari, Rx, Adya, R. X., (Adya, Vb, Affeldt, V. B., (Affeldt, C, Agathos, C., (Agathos, M, Agatsuma, M., (Agatsuma, K, Aggarwal, K., (Aggarwal, N, Aguiar, N., (Aguiar, Od, Aiello, O. D., (Aiello, L, Ain, L., (Ain, A, Ajith, A., (Ajith, P, Allen, P., (Allen, G, Allocca, G., (Allocca, A, Aloy, A., (Aloy, Ma, Altin, M. A., (Altin, Pa, Amato, P. A., (Amato, A, Ananyeva, A., (Ananyeva, A, Anderson, A., (Anderson, Sb, Anderson, S. B., (Anderson, Wg, Angelova, W. G., (Angelova, Sv, V), S., Antier, (Antier, S, Appert, S., (Appert, S, Arai, S., (Arai, K, Araya, K., (Araya, Mc, Areeda, M. C., (Areeda, Js, Arene, J. S., (Arene, M, Arnaud, M., (Arnaud, N, Ascenzi, N., (Ascenzi, S, Ashton, S., (Ashton, G, Aston, G., (Aston, Sm, Astone, S. M., (Astone, P, Aubin, P., (Aubin, F, Aufmuth, F., (Aufmuth, P, AultONeal, P., (AultONeal, K, Austin, K., (Austin, C, Avendano, C., (Avendano, V, Avila-Alvarez, V), (Avila-Alvarez, A, Babak, A., (Babak, S, Bacon, S., (Bacon, P, Badaracco, P., (Badaracco, F, Bader, F., Mkm, (Bader, Bae, M. K. M., (Bae, S, Baker, S., (Baker, Pt, Baldaccini, P. T., (Baldaccini, F, Ballardin, F., (Ballardin, G, Ballmer, G., (Ballmer, Sw, Banagiri, S. W., (Banagiri, S, Barayoga, S., (Barayoga, Jc, Barclay, J. C., (Barclay, Se, Barish, S. E., (Barish, Bc, Barker, B. C., (Barker, D, Barkett, D., (Barkett, K, Barnum, K., (Barnum, S, Barone, S., (Barone, F, Barr, F., (Barr, B, Barsotti, B., (Barsotti, L, Barsuglia, L., (Barsuglia, M, Barta, M., (Barta, D, Bartlett, D., (Bartlett, J, Bartos, J., (Bartos, I, Bassiri, I), (Bassiri, R, Basti, R., (Basti, A, Bawaj, A., (Bawaj, M, Bayley, M., (Bayley, Jc, Bazzan, J. C., (Bazzan, M, Becsy, M., (Becsy, B, Bejger, B., (Bejger, M, Belahcene, M., (Belahcene, I, Bell, I), (Bell, As, Beniwal, A. S., (Beniwal, D, Berger, D., (Berger, Bk, Bergmann, B. K., (Bergmann, G, Bernuzzi, G., (Bernuzzi, S, Bero, S., (Bero, Jj, Berry, J. J., Cpl, (Berry, Bersanetti, C. P. L., (Bersanetti, D, Bertolini, D., (Bertolini, A, Betzwieser, A., (Betzwieser, J, Bhandare, J., (Bhandare, R, Bidler, R., (Bidler, J, Bilenko, J., (Bilenko, Ia, Bilgili, I. A., (Bilgili, Sa, Billingsley, S. A., (Billingsley, G, Birch, G., (Birch, J, Birney, J., (Birney, R, Birnholtz, R., (Birnholtz, O, Biscans, O., (Biscans, S, Biscoveanu, S., (Biscoveanu, S, Bisht, S., (Bisht, A, Bitossi, A., (Bitossi, M, Bizouard, M., (Bizouard, Ma, Blackburn, M. A., (Blackburn, Jk, Blair, J. K., (Blair, Cd, Blair, C. D., (Blair, Dg, Blair, D. G., (Blair, Rm, Bloemen, R. M., (Bloemen, S, Bode, S., (Bode, N, Boer, N., (Boer, M, Boetzel, M., (Boetzel, Y, Bogaert, Y., (Bogaert, G, Bondu, G., (Bondu, F, Bonilla, F., (Bonilla, E, Bonnand, E., (Bonnand, R, Booker, R., (Booker, P, Boom, P., (Boom, Ba, Booth, B. A., (Booth, Cd, Bork, C. D., (Bork, R, Boschi, R., (Boschi, V, Bose, V), (Bose, S, Bossie, S., (Bossie, K, Bossilkov, K., (Bossilkov, V, Bosveld, V), (Bosveld, J, Bouffanais, J., (Bouffanais, Y, Bozzi, Y., (Bozzi, A, Bradaschia, A., (Bradaschia, C, Brady, C., (Brady, Pr, Bramley, P. R., (Bramley, A, Branchesi, A., (Branchesi, M, Brau, M., (Brau, Je, Briant, J. E., (Briant, T, Briggs, T., (Briggs, Jh, Brighenti, J. H., (Brighenti, F, Brillet, F., (Brillet, A, Brinkmann, A., (Brinkmann, M, Brisson, M., (Brisson, V, Brockill, V), (Brockill, P, Brooks, P., (Brooks, Af, Brown, A. F., (Brown, Dd, Brunett, D. D., (Brunett, S, Buikema, S., (Buikema, A, Bulik, A., (Bulik, T, Bulten, T., (Bulten, Hj, Buonanno, H. 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L., Manske21, M., Mantovani28, M., Marchesoni40, F., Marion32, F., Márka97, S., Márka97, Z., Markakis10, C., Markosyan48, A. S., Markowitz1, A., Maros1, E., Marquina101, A., Marsat35, S., Martelli71, F., Martin43, I. W., Martin34, R. M., Martynov11, D. V., Mason12, K., Massera107, E., Masserot32, A., Massinger1, T. J., Masso-Reid43, M., Mastrogiovanni31, S., Matas35, A., Matichard1, F., Matone97, L., Mavalvala12, N., Mazumder68, N., Mccann62, J. J., Mccarthy44, R., Mcclelland21, D. E., Mccormick7, S., Mcculler12, L., Mcguire154, S. C., Mciver1, J., Mcmanus21, D. J., Mcrae21, T., Mcwilliams38, S. T., Meacher86, D., Meadors6, G. D., Mehmet8, M., Mehta16, A. K., Meidam36, J., Melatos96, A., Mendell44, G., Mercer23, R. A., Mereni22, L., Merilh44, E. L., Merzougui64, M., Meshkov1, S., Messenger43, C., Messick86, C., Metzdorff70, R., Meyers96, P. M., Miao11, H., Michel22, C., Middleton96, H., Mikhailov155, E. E., Milano, L., Miller47, A. L., Miller31, A., Millhouse52, M., Mills67, J. C., Milovich-Goff110, M. C., Minazzoli64, O., Minenkov30, Y., Mishkin47, A., Mishra157, C., Mistry107, T., Mitra3, S., Mitrofanov61, V. P., Mitselmakher47, G., Mittleman12, R., Mo93, G., Moffa114, D., Mogushi84, K., Mohapatra12, S. R. P., Montani71, M., Moore10, C. J., Moraru44, D., Moreno44, G., Morisaki81, S., Mours32, B., Mow-Lowry11, C. M., Mukherjee8, Arunava, Mukherjee23, D., Mukherjee103, S., Mukund3, N., Mullavey7, A., Munch54, J., Muñiz41, E. A., Muratore33, M., Murray43, P. G., Nagar85, A., 159, 158, Nardecchia29, I., Naticchioni31, L., Nayak160, R. K., Neilson110, J., Nelemans36, G., Nelson7, T. J. N., Nery8, M., Neunzert125, A., Ng12, K. Y., Ng54, S., Nguyen69, P., Nichols36, D., Nissanke36, S., Nitz8, A., Nocera28, F., North67, C., Nuttall153, L. K., Obergaulinger20, M., Oberling44, J., O'Brien47, B. D., O'Dea110, G. D., Ogin161, G. H., Oh137, J. J., Oh137, S. H., Ohme8, F., Ohta81, H., Okada13, M. A., Oliver98, M., Oppermann8, P., Oram7, Richard J., O'Reilly7, B., Ormiston42, R. G., Ortega47, L. F., O'Shaughnessy57, R., Ossokine35, S., Ottaway54, D. J., Overmier7, H., Owen83, B. J., Pace86, A. E., Pagano18, G., Page62, M. A., Pai121, A., Pai60, S. A., Palamos69, J. R., Palashov134, O., Palomba31, C., Pal-Singh139, A., Pan87, Huang-Wei, Pang45, B., Pang90, P. T. H., Pankow58, C., Pannarale31, F., Pant60, B. C., Paoletti19, F., Paoli28, A., Parida3, A., Parker7, W., Pascucci43, D., Pasqualetti28, A., Passaquieti18, R., Passuello19, D., Patil143, M., Patricelli18, B., Pearlstone43, B. L., Pedersen67, C., Pedraza1, M., Pedurand22, R., Pele7, A., Penn163, S., Perez44, C. J., Perreca95, A., Pfeiffer35, H. P., Phelps8, M., Phukon3, K. S., Piccinni31, O. J., Pichot64, M., Piergiovanni71, F., Pillant28, G., Pinard22, L., Pirello44, M., Pitkin43, M., Poggiani18, R., Pong90, D. Y. T., Ponrathnam3, S., Popolizio28, P., Porter27, E. K., Powell152, J., Prajapati106, A. K., Prasad3, J., Prasai48, K., Prasanna129, R., Pratten98, G., Prestegard23, T., Privitera35, S., Prodi95, G. A., Prokhorov61, L. G., Puncken8, O., Punturo40, M., Puppo31, P., Pürrer35, M., Qi23, H., Quetschke103, V., Quinonez33, P. J., Quintero1, E. A., Quitzow-James69, R., Raab44, F. J., Radkins44, H., Radulescu64, N., Raffai105, P., Raja60, S., Rajan60, C., Rajbhandari83, B., Rakhmanov103, M., Ramirez103, K. E., Ramos-Buades98, A., Rana3, Javed, Rao58, K., Rapagnani31, P., Raymond67, V., Razzano18, M., Read26, J., Regimbau32, T., Rei59, L., Reid24, S., Reitze1, D. H., Ren17, W., Ricci31, F., Richardson33, C. J., Richardson1, J. W., Ricker17, P. M., Riles125, K., Rizzo58, M., Robertson1, N. A., Robie43, R., Robinet25, F., Rocchi30, A., Rolland32, L., Rollins1, J. G., Roma69, V. J., Romanelli66, M., Romano4, R., Romel44, C. L., Romie7, J. H., Rose114, K., Rosińska53, D., Rosofsky17, S. G., Ross165, M. P., Rowan43, S., Rüdiger8, A., 180, 9, Ruggi28, P., Rutins166, G., Ryan44, K., Sachdev1, S., Sadecki44, T., Sakellariadou131, M., Salconi28, L., Saleem141, M., Samajdar36, A., Sammut6, L., Sanchez1, E. J., Sanchez1, L. E., Sanchis-Gual20, N., Sandberg44, V., Sanders41, J. R., Santiago34, K. A., Sarin6, N., Sassolas22, B., Saulson41, P. R., Sauter125, O., Savage44, R. L., Schale69, P., Scheel45, M., Scheuer58, J., Schmidt63, P., Schnabel139, R., Schofield69, R. M. S., Schönbeck139, A., Schreiber8, E., Schulte8, B. W., Schutz67, B. F., Schwalbe33, S. G., Scott43, J., Scott21, S. M., Seidel17, E., Sellers7, D., Sengupta167, A. S., Sennett35, N., Sentenac28, D., Sequino14, V., Sergeev134, A., Setyawati8, Y., Shaddock21, D. A., Shaffer44, T., Shahriar58, M. S., Shaner110, M. B., Shao35, L., Sharma60, P., Shawhan75, P., Shen17, H., Shink168, R., Shoemaker12, D. H., Shoemaker76, D. M., Shyamsundar60, S., Siellez76, K., Sieniawska53, M., Sigg44, D., Silva13, A. D., Singer79, L. 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A., Thrane6, E., Tiwari95, Shubhanshu, Tiwari123, Srishti, Tiwari67, V., Toland43, K., Tonelli18, M., Tornasi43, Z., Torres-Forné173, A., Torrie1, C. I., Töyrä11, D., Travasso28, F., Traylor7, G., Tringali73, M. C., Trovato27, A., Trozzo19, L., Trudeau1, R., Tsang36, K. W., Tse12, M., Tso45, R., Tsukada81, L., Tsuna81, D., Tuyenbayev103, D., Ueno81, K., Ugolini175, D., Unnikrishnan123, C. S., Urban2, A. L., Usman67, S. A., Vahlbruch9, H., Vajente1, G., Valdes2, G., van Bakel36, N., van Beuzekom36, M., van den Brand36, J. F. J., Van Den Broeck36, C., Vander-Hyde41, D. C., van Heijningen62, J. V., van der Schaaf36, L., van Veggel43, A. A., Vardaro50, M., Varma45, V., Vass1, S., Vasúth46, M., Vecchio11, A., Vedovato51, G., Veitch43, J., Veitch54, P. J., Venkateswara165, K., Venugopalan1, G., Verkindt32, D., Vetrano71, F., Viceré71, A., Viets23, A. D., Vine166, D. J., Vinet64, J. -Y., Vitale12, S., Vo41, T., Vocca39, H., Vorvick44, C., Vyatchanin61, S. P., Wade1, A. R., Wade114, L. E., Wade114, M., Walet36, R., Walker26, M., Wallace1, L., Walsh23, S., Wang14, G., Wang11, H., Wang125, J. Z., Wang103, W. H., Wang90, Y. F., Ward21, R. L., Warden33, Z. A., Warner44, J., Was32, M., Watchi99, J., Weaver44, B., Wei8, L. -W., Weinert8, M., Weinstein1, A. J., Weiss12, R., Wellmann8, F., Wen62, L., Wessel17, E. K., Weßels8, P., Westhouse33, J. W., Wette21, K., Whelan57, J. T., Whiting47, B. F., Whittle12, C., Wilken8, D. M., Williams43, D., Williamson36, A. R., Willis1, J. L., Willke8, B., Wimmer8, M. H., Winkler8, W., Wipf1, C. C., Wittel8, H., Woan43, G., Woehler8, J., Wofford57, J. K., Worden44, J., Wright43, J. L., Wu8, D. S., Wysocki57, D. M., Xiao1, L., Yamamoto1, H., Yancey75, C. C., Yang113, L., Yap21, M. J., Yazback47, M., Yeeles67, D. W., Yu12, Hang, Yu12, Haocun, Yuen90, S. H. R., Yvert32, M., Zadrożny103, A. 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Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Abbott, Bp, Abbott, R, Abbott, Td, Abraham, S, Acernese, F, Ackley, K, Adams, C, Adhikari, Rx, Adya, Vb, Affeldt, C, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, Od, Aiello, L, Ain, A, Ajith, P, Allen, G, Allocca, A, Aloy, Ma, Altin, Pa, Amato, A, Ananyeva, A, Anderson, Sb, Anderson, Wg, Angelova, Sv, Antier, S, Appert, S, Arai, K, Araya, Mc, Areeda, J, Arene, M, Arnaud, N, Ascenzi, S, Ashton, G, Aston, Sm, Astone, P, Aubin, F, Aufmuth, P, Aultoneal, K, Austin, C, Avendano, V, Avila-Alvarez, A, Babak, S, Bacon, P, Badaracco, F, Bader, Mkm, Bae, S, Baker, Pt, Baldaccini, F, Ballardin, G, Ballmer, Sw, Banagiri, S, Barayoga, Jc, Barclay, Se, Barish, Bc, Barker, D, Barkett, K, Barnum, S, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Bartos, I, Bassiri, R, Basti, A, Bawaj, M, Bayley, Jc, Bazzan, M, Becsy, B, Bejger, M, Belahcene, I, Bell, A, Beniwal, D, Berger, Bk, Bergmann, G, Bernuzzi, S, Bero, Jj, Berry, Cpl, Bersanetti, D, Bertolini, A, Betzwieser, J, Bhandare, R, Bidler, J, Bilenko, Ia, Bilgili, Sa, Billingsley, G, Birch, J, Birney, R, Birnholtz, O, Biscans, S, Biscoveanu, S, Bisht, A, Bitossi, M, Bizouard, Ma, Blackburn, Jk, Blair, Cd, Blair, Dg, Blair, Rm, Bloemen, S, Bode, N, Boer, M, Boetzel, Y, Bogaert, G, Bondu, F, Bonilla, E, Bonnand, R, Booker, P, Boom, Ba, Booth, Cd, Bork, R, Boschi, V, Bose, S, Bossie, K, Bossilkov, V, Bosveld, J, Bouffanais, Y, Bozzi, A, Bradaschia, C, Brady, Pr, Bramley, A, Branchesi, M, Brau, Je, Briant, T, Briggs, Jh, Brighenti, F, Brillet, A, Brinkmann, M, Brisson, V, Brockill, P, Brooks, Af, Brown, Dd, Brunett, S, Buikema, A, Bulik, T, Bulten, Hj, Buonanno, A, Buskulic, D, Buy, C, Byer, Rl, Cabero, M, Cadonati, L, Cagnoli, G, Cahillane, C, Bustillo, Jc, Callister, Ta, Calloni, E, Camp, Jb, Campbell, Wa, Canepa, M, Cannon, Kc, Cao, H, Cao, J, Capocasa, E, Carbognani, F, Caride, S, Carney, Mf, Carullo, G, Diaz, Jc, Casentini, C, Caudill, S, Cavaglia, M, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cerretani, G, Cesarini, E, Chaibi, O, Chakravarti, K, Chamberlin, Sj, Chan, M, Chao, S, Charlton, P, Chase, Ea, Chassande-Mottin, E, Chatterjee, D, Chaturvedi, M, Cheeseboro, Bd, Chen, Hy, Chen, X, Chen, Y, Cheng, Hp, Cheong, Ck, Chia, Hy, Chincarini, A, Chiummo, A, Cho, G, Cho, H, Cho, M, Christensen, N, Chu, Q, Chua, S, Chung, Kw, Chung, S, Ciani, G, Ciobanu, Aa, Ciolfi, R, Cipriano, F, Cirone, A, Clara, F, Clark, Ja, Clearwater, P, Cleva, F, Cocchieri, C, Coccia, E, Cohadon, Pf, Cohen, D, Colgan, R, Colleoni, M, Collette, Cg, Collins, C, Cominsky, Lr, Constancio, M, Conti, L, Cooper, Sj, Corban, P, Corbitt, Tr, Cordero-Carrion, I, Corley, Kr, Cornish, N, Corsi, A, Cortese, S, Costa, Ca, Cotesta, R, Coughlin, Mw, Coughlin, Sb, Coulon, Jp, Countryman, St, Couvares, P, Covas, Pb, Cowan, Ee, Coward, Dm, Cowart, Mj, Coyne, Dc, Coyne, R, Creighton, Jde, Creighton, Td, Cripe, J, Croquette, M, Crowder, Sg, Cullen, Tj, Cumming, A, Cunningham, L, Cuoco, E, Dal Canton, T, Dalya, G, Danilishin, Sl, D'Antonio, S, Danzmann, K, Dasgupta, A, Costa, Cfd, Datrier, Leh, Dattilo, V, Dave, I, Davier, M, Davis, D, Daw, Ej, Debra, D, Deenadayalan, M, Degallaix, J, De Laurentis, M, Deleglise, S, Del Pozzo, W, Demarchi, Lm, Demos, N, Dent, T, De Pietri, R, Derby, J, De Rosa, R, De Rossi, C, Desalvo, R, de Varona, O, Dhurandhar, S, Diaz, Mc, Dietrich, T, Di Fiore, L, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Ding, B, Di Pace, S, Di Palma, I, Di Renzo, F, Dmitriev, A, Doctor, Z, Donovan, F, Dooley, Kl, Doravari, S, Dorrington, I, Downes, Tp, Drago, M, Driggers, Jc, Du, Z, Ducoin, Jg, Dupej, P, Dwyer, Se, Easter, Pj, Edo, Tb, Edwards, Mc, Effler, A, Ehrens, P, Eichholz, J, Eikenberry, S, Eisenmann, M, Eisenstein, Ra, Essick, Rc, Estelles, H, Estevez, D, Etienne, Zb, Etzel, T, Evans, M, Evans, Tm, Fafone, V, Fair, H, Fairhurst, S, Fan, X, Farinon, S, Farr, B, Farr, Wm, Fauchon-Jones, Ej, Favata, M, Fays, M, Fazio, M, Fee, C, Feicht, J, Fejer, Mm, Feng, F, Fernandez-Galiana, A, Ferrante, I, Ferreira, Ec, Ferreira, Ta, Ferrini, F, Fidecaro, F, Fiori, I, Fiorucci, D, Fishbach, M, Fisher, Rp, Fishner, Jm, Fitz-Axen, M, Flaminio, R, Fletcher, M, Flynn, E, Fong, H, Font, Ja, Forsyth, Pwf, Fournier, Jd, Frasca, S, Frasconi, F, Frei, Z, Freise, A, Frey, R, Frey, V, Fritschel, P, Frolov, Vv, Fulda, P, Fyffe, M, Gabbard, Ha, Gadre, Bu, Gaebel, Sm, Gair, Jr, Gammaitoni, L, Ganija, Mr, Gaonkar, Sg, Garcia, A, Garcia-Quiros, C, Garufi, F, Gateley, B, Gaudio, S, Gaur, G, Gayathri, V, Gemme, G, Genin, E, Gennai, A, George, D, George, J, Gergely, L, Germain, V, Ghonge, S, Ghosh, A, Ghosh, S, Giacomazzo, B, Giaime, Ja, Giardina, Kd, Giazotto, A, Gill, K, Giordano, G, Glover, L, Godwin, P, Goetz, E, Goetz, R, Goncharov, B, Gonzalez, G, Castro, Jmg, Gopakumar, A, Gorodetsky, Ml, Gossan, Se, Gosselin, M, Gouaty, R, Grado, A, Graef, C, Granata, M, Grant, A, Gras, S, Grassia, P, Gray, C, Gray, R, Greco, G, Green, Ac, Green, R, Gretarsson, Em, Groot, P, Grote, H, Grunewald, S, Gruning, P, Guidi, Gm, Gulati, Hk, Guo, Y, Gupta, A, Gupta, Mk, Gustafson, Ek, Gustafson, R, Haegel, L, Halim, O, Hall, Br, Hall, Ed, Hamilton, Ez, Hammond, G, Haney, M, Hanke, Mm, Hanks, J, Hanna, C, Hannuksela, Oa, Hanson, J, Hardwick, T, Haris, K, Harms, J, Harry, Gm, Harry, Iw, Haster, Cj, Haughian, K, Hayes, Fj, Healy, J, Heidmann, A, Heintze, Mc, Heitmann, H, Hello, P, Hemming, G, Hendry, M, Heng, I, Hennig, J, Heptonstall, Aw, Vivanco, Fh, Heurs, M, Hild, S, Hinderer, T, Hoak, D, Hochheim, S, Hofman, D, Holgado, Am, Holland, Na, Holt, K, Holz, De, Hopkins, P, Horst, C, Hough, J, Howell, Ej, Hoy, Cg, Hreibi, A, Huerta, Ea, Huet, D, Hughey, B, Hulko, M, Husa, S, Huttner, Sh, Huynh-Dinh, T, Idzkowski, B, Iess, A, Ingram, C, Inta, R, Intini, G, Irwin, B, Isa, Hn, Isac, Jm, Isi, M, Iyer, Br, Izumi, K, Jacqmin, T, Jadhav, Sj, Jani, K, Janthalur, Nn, Jaranowski, P, Jenkins, Ac, Jiang, J, Johnson, D, Jones, Aw, Jones, Di, Jones, R, Jonker, Rjg, Ju, L, Junker, J, Kalaghatgi, Cv, Kalogera, V, Kamai, B, Kandhasamy, S, Kang, G, Kanner, Jb, Kapadia, Sj, Karki, S, Karvinen, K, Kashyap, R, Kasprzack, M, Katsanevas, S, Katsavounidis, E, Katzman, W, Kaufer, S, Kawabe, K, Keerthana, Nv, Kefelian, F, Keitel, D, Kennedy, R, Key, J, Khalili, Fy, Khan, H, Khan, I, Khan, S, Khan, Z, Khazanov, Ea, Khursheed, M, Kijbunchoo, N, Kim, C, Kim, Jc, Kim, K, Kim, W, Kim, Ym, Kimball, C, King, Ej, King, Pj, Kinley-Hanlon, M, Kirchhoff, R, Kissel, J, Kleybolte, L, Klika, Jh, Klimenko, S, Knowles, Td, Koch, P, Koehlenbeck, Sm, Koekoek, G, Koley, S, Kondrashov, V, Kontos, A, Koper, N, Korobko, M, Korth, Wz, Kowalska, I, Kozak, Db, Kringel, V, Krishnendu, N, Krolak, A, Kuehn, G, Kumar, A, Kumar, P, Kumar, R, Kumar, S, Kuo, L, Kutynia, A, Kwang, S, Lackey, Bd, Lai, Kh, Lam, Tl, Landry, M, Lane, Bb, Lang, Rn, Lange, J, Lantz, B, Lanza, Rk, Lartaux-Vollard, A, Lasky, Pd, Laxen, M, Lazzarini, A, Lazzaro, C, Leaci, P, Leavey, S, Lecoeuche, Yk, Lee, Ch, Lee, Hk, Lee, Hm, Lee, Hw, Lee, J, Lee, K, Lehmann, J, Lenon, A, Leroy, N, Letendre, N, Levin, Y, Li, J, Li, Kjl, Li, Tgf, Li, X, Lin, F, Linde, F, Linker, Sd, Littenberg, Tb, Liu, J, Liu, X, Lo, Rkl, Lockerbie, Na, London, Lt, Longo, A, Lorenzini, M, Loriette, V, Lormand, M, Losurdo, G, Lough, Jd, Lousto, Co, Lovelace, G, Lower, Me, Luck, H, Lumaca, D, Lundgren, Ap, Lynch, R, Ma, Y, Macas, R, Macfoy, S, Macinnis, M, Macleod, Dm, Macquet, A, Magana-Sandoval, F, Zertuche, Lm, Magee, Rm, Majorana, E, Maksimovic, I, Malik, A, Man, N, Mandic, V, Mangano, V, Mansell, Gl, Manske, M, Mantovani, M, Marchesoni, F, Marion, F, Marka, S, Marka, Z, Markakis, C, Markosyan, A, Markowitz, A, Maros, E, Marquina, A, Marsat, S, Martelli, F, Martin, Iw, Martin, Rm, Martynov, Dv, Mason, K, Massera, E, Masserot, A, Massinger, Tj, Masso-Reid, M, Mastrogiovanni, S, Matas, A, Matichard, F, Matone, L, Mavalvala, N, Mazumder, N, Mccann, Jj, Mccarthy, R, Mcclelland, De, Mccormick, S, Mcculler, L, Mcguire, Sc, Mciver, J, Mcmanus, Dj, Mcrae, T, Mcwilliams, St, Meacher, D, Meadors, Gd, Mehmet, M, Mehta, Ak, Meidam, J, Melatos, A, Mendell, G, Mercer, Ra, Mereni, L, Merilh, El, Merzougui, M, Meshkov, S, Messenger, C, Messick, C, Metzdorff, R, Meyers, Pm, Miao, H, Michel, C, Middleton, H, Mikhailov, Ee, Milano, L, Miller, Al, Miller, A, Millhouse, M, Mills, Jc, Milovich-Goff, Mc, Minazzoli, O, Minenkov, Y, Mishkin, A, Mishra, C, Mistry, T, Mitra, S, Mitrofanov, Vp, Mitselmakher, G, Mittleman, R, Mo, G, Moffa, D, Mogushi, K, Mohapatra, Srp, Montani, M, Moore, Cj, Moraru, D, Moreno, G, Morisaki, S, Mours, B, Mow-Lowry, Cm, Mukherjee, A, Mukherjee, D, Mukherjee, S, Mukund, N, Mullavey, A, Munch, J, Muniz, Ea, Muratore, M, Murray, Pg, Nagar, A, Nardecchia, I, Naticchioni, L, Nayak, Rk, Neilson, J, Nelemans, G, Nelson, Tjn, Nery, M, Neunzert, A, Ng, Ky, Ng, S, Nguyen, P, Nichols, D, Nissanke, S, Nitz, A, Nocera, F, North, C, Nuttall, Lk, Obergaulinger, M, Oberling, J, O'Brien, Bd, O'Dea, Gd, Ogin, Gh, Oh, Jj, Oh, Sh, Ohme, F, Ohta, H, Okada, Ma, Oliver, M, Oppermann, P, Oram, Rj, O'Reilly, B, Ormiston, Rg, Ortega, Lf, O'Shaughnessy, R, Ossokine, S, Ottaway, Dj, Overmier, H, Owen, Bj, Pace, Ae, Pagano, G, Page, Ma, Pai, A, Pai, Sa, Palamos, Jr, Palashov, O, Palomba, C, Pal-Singh, A, Pan, Hw, Pang, B, Pang, Pth, Pankow, C, Pannarale, F, Pant, Bc, Paoletti, F, Paoli, A, Parida, A, Parker, W, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patil, M, Patricelli, B, Pearlstone, Bl, Pedersen, C, Pedraza, M, Pedurand, R, Pele, A, Penn, S, Perez, Cj, Perreca, A, Pfeiffer, Hp, Phelps, M, Phukon, K, Piccinni, Oj, Pichot, M, Piergiovanni, F, Pillant, G, Pinard, L, Pirello, M, Pitkin, M, Poggiani, R, Pong, Dyt, Ponrathnam, S, Popolizio, P, Porter, Ek, Powell, J, Prajapati, Ak, Prasad, J, Prasai, K, Prasanna, R, Pratten, G, Prestegard, T, Privitera, S, Prodi, Ga, Prokhorov, Lg, Puncken, O, Punturo, M, Puppo, P, Purrer, M, Qi, H, Quetschke, V, Quinonez, Pj, Quintero, Ea, Quitzow-James, R, Raab, Fj, Radkins, H, Radulescu, N, Raffai, P, Raja, S, Rajan, C, Rajbhandari, B, Rakhmanov, M, Ramirez, Ke, Ramos-Buades, A, Rana, J, Rao, K, Rapagnani, P, Raymond, V, Razzano, M, Read, J, Regimbau, T, Rei, L, Reid, S, Reitze, Dh, Ren, W, Ricci, F, Richardson, Cj, Richardson, Jw, Ricker, Pm, Riles, K, Rizzo, M, Robertson, Na, Robie, R, Robinet, F, Rocchi, A, Rolland, L, Rollins, Jg, Roma, Vj, Romanelli, M, Romano, R, Romel, Cl, Romie, Jh, Rose, K, Rosinska, D, Rosofsky, Sg, Ross, Mp, Rowan, S, Rudiger, A, Ruggi, P, Rutins, G, Ryan, K, Sachdev, S, Sadecki, T, Sakellariadou, M, Salconi, L, Saleem, M, Samajdar, A, Sammut, L, Sanchez, Ej, Sanchez, Le, Sanchis-Gual, N, Sandberg, V, Sanders, Jr, Santiago, Ka, Sarin, N, Sassolas, B, Saulson, Pr, Sauter, O, Savage, Rl, Schale, P, Scheel, M, Scheuer, J, Schmidt, P, Schnabel, R, Schofield, Rm, Schonbeck, A, Schreiber, E, Schulte, Bw, Schutz, Bf, Schwalbe, Sg, Scott, J, Scott, Sm, Seidel, E, Sellers, D, Sengupta, A, Sennett, N, Sentenac, D, Sequino, V, Sergeev, A, Setyawati, Y, Shaddock, Da, Shaffer, T, Shahriar, M, Shaner, Mb, Shao, L, Sharma, P, Shawhan, P, Shen, H, Shink, R, Shoemaker, Dh, Shoemaker, Dm, Shyamsundar, S, Siellez, K, Sieniawska, M, Sigg, D, Silva, Ad, Singer, Lp, Singh, N, Singhal, A, Sintes, Am, Sitmukhambetov, S, Skliris, V, Slagmolen, Bjj, Slaven-Blair, Tj, Smith, Jr, Smith, Rje, Somala, S, Son, Ej, Sorazu, B, Sorrentino, F, Souradeep, T, Sowell, E, Spencer, Ap, Srivastava, Ak, Srivastava, V, Staats, K, Stachie, C, Standke, M, Steer, Da, Steinke, M, Steinlechner, J, Steinlechner, S, Steinmeyer, D, Stevenson, Sp, Stocks, D, Stone, R, Stops, Dj, Strain, Ka, Stratta, G, Strigin, Se, Strunk, A, Sturani, R, Stuver, Al, Sudhir, V, Summerscales, Tz, Sun, L, Sunil, S, Suresh, J, Sutton, Pj, Swinkels, Bl, Szczepanczyk, Mj, Tacca, M, Tait, Sc, Talbot, C, Talukder, D, Tanner, Db, Tapai, M, Taracchini, A, Tasson, Jd, Taylor, R, Thies, F, Thomas, M, Thomas, P, Thondapu, Sr, Thorne, Ka, Thrane, E, Tiwari, S, Tiwari, V, Toland, K, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, Ci, Toyra, D, Travasso, F, Traylor, G, Tringali, Mc, Trovato, A, Trozzo, L, Trudeau, R, Tsang, Kw, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tuyenbayev, D, Ueno, K, Ugolini, D, Unnikrishnan, C, Urban, Al, Usman, Sa, Vahlbruch, H, Vajente, G, Valdes, G, van Bakel, N, van Beuzekom, M, van den Brand, Jfj, Van den Broeck, C, Vander-Hyde, Dc, van Heijningen, Jv, van der Schaaf, L, van Veggel, Aa, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, Pj, Venkateswara, K, Venugopalan, G, Verkindt, D, Vetrano, F, Vicere, A, Viets, Ad, Vine, Dj, Vinet, Jy, Vitale, S, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, Sp, Wade, Ar, Wade, Le, Wade, M, Walet, R, Walker, M, Wallace, L, Walsh, S, Wang, G, Wang, H, Wang, Jz, Wang, Wh, Wang, Yf, Ward, Rl, Warden, Za, Warner, J, Was, M, Watchi, J, Weaver, B, Wei, Lw, Weinert, M, Weinstein, Aj, Weiss, R, Wellmann, F, Wen, L, Wessel, Ek, Wessels, P, Westhouse, Jw, Wette, K, Whelan, Jt, Whiting, Bf, Whittle, C, Wilken, Dm, Williams, D, Williamson, Ar, Willis, Jl, Willke, B, Wimmer, Mh, Winkler, W, Wipf, Cc, Wittel, H, Woan, G, Woehler, J, Wofford, Jk, Worden, J, Wright, Jl, Wu, D, Wysocki, Dm, Xiao, L, Yamamoto, H, Yancey, Cc, Yang, L, Yap, Mj, Yazback, M, Yeeles, Dw, Yu, H, Yu, Hc, Yuen, Shr, Yvert, M, Zadrozny, Ak, Zanolin, M, Zelenova, T, Zendri, Jp, Zevin, M, Zhang, J, Zhang, L, Zhang, T, Zhao, C, Zhou, M, Zhou, Z, Zimmerman, Ab, Zhu, Xj, Zucker, Me, Zweizig, J, Abbott, B, Abbott, T, Adhikari, R, Adya, V, Aguiar, O, Aloy, M, Altin, P, Anderson, S, Anderson, W, Angelova, S, Araya, M, Aston, S, Bader, M, Baker, P, Ballmer, S, Barayoga, J, Barclay, S, Barish, B, Bayley, J, Berger, B, Bero, J, Berry, C, Bilenko, I, Bilgili, S, Bizouard, M, Blackburn, J, Blair, C, Blair, D, Blair, R, Boom, B, Booth, C, Brady, P, Brau, J, Briggs, J, Brooks, A, Brown, D, Bulten, H, Byer, R, Bustillo, J, Callister, T, Camp, J, Campbell, W, Cannon, K, Carney, M, Diaz, J, Chamberlin, S, Chase, E, Cheeseboro, B, Chen, H, Cheng, H, Cheong, C, Chia, H, Chung, K, Ciobanu, A, Clark, J, Cohadon, P, Collette, C, Cominsky, L, Cooper, S, Corbitt, T, Corley, K, Costa, C, Coughlin, M, Coughlin, S, Coulon, J, Countryman, S, Covas, P, Cowan, E, Coward, D, Cowart, M, Coyne, D, Creighton, J, Creighton, T, Crowder, S, Cullen, T, Canton, T, Danilishin, S, Datrier, L, Daw, E, Pozzo, W, Demarchi, L, De Varona, O, Diaz, M, Fiore, L, Giovanni, M, Girolamo, T, Lieto, A, Pace, S, Palma, I, Renzo, F, Dooley, K, Downes, T, Driggers, J, Ducoin, J, Dwyer, S, Easter, P, Edo, T, Edwards, M, Eisenstein, R, Essick, R, Etienne, Z, Evans, T, Farr, W, Fauchon-Jones, E, Fejer, M, Ferreira, E, Ferreira, T, Fisher, R, Fishner, J, Font, J, Forsyth, P, Fournier, J, Frolov, V, Gabbard, H, Gadre, B, Gaebel, S, Gair, J, Ganija, M, Gaonkar, S, Giaime, J, Giardina, K, Castro, J, Gorodetsky, M, Gossan, S, Green, A, Gretarsson, E, Guidi, G, Gulati, H, Gupta, M, Gustafson, E, Hall, B, Hall, E, Hamilton, E, Hanke, M, Hannuksela, O, Harry, G, Harry, I, Haster, C, Hayes, F, Heintze, M, Heptonstall, A, Vivanco, F, Holgado, A, Holland, N, Holz, D, Howell, E, Hoy, C, Huerta, E, Huttner, S, Isa, H, Isac, J, Iyer, B, Jadhav, S, Janthalur, N, Jenkins, A, Jones, A, Jones, D, Jonker, R, Kalaghatgi, C, Kanner, J, Kapadia, S, Keerthana, N, Khalili, F, Khazanov, E, Kim, J, Kim, Y, King, E, King, P, Klika, J, Knowles, T, Koehlenbeck, S, Korth, W, Kozak, D, Lackey, B, Lai, K, Lam, T, Lane, B, Lang, R, Lanza, R, Lasky, P, Lecoeuche, Y, Lee, C, Lee, H, Li, K, Li, T, Linker, S, Littenberg, T, Lo, R, Lockerbie, N, London, L, Lough, J, Lousto, C, Lower, M, Lundgren, A, Macleod, D, Zertuche, L, Magee, R, Mansell, G, Martin, I, Martin, R, Martynov, D, Massinger, T, Mccann, J, Mcclelland, D, Mcguire, S, Mcmanus, D, Mcwilliams, S, Meadors, G, Mehta, A, Mercer, R, Merilh, E, Meyers, P, Mikhailov, E, Mills, J, Milovich-Goff, M, Mitrofanov, V, Mohapatra, S, Moore, C, Mow-Lowry, C, Muniz, E, Murray, P, Nayak, R, Nelson, T, Ng, K, Nuttall, L, O'Brien, B, O'Dea, G, Ogin, G, Oh, J, Oh, S, Okada, M, Oram, R, Ormiston, R, Ortega, L, Ottaway, D, Owen, B, Pace, A, Page, M, Pai, S, Palamos, J, Pan, H, Pang, P, Pant, B, Pearlstone, B, Perez, C, Pfeiffer, H, Piccinni, O, Pong, D, Porter, E, Prajapati, A, Prodi, G, Prokhorov, L, Quinonez, P, Quintero, E, Raab, F, Ramirez, K, Reitze, D, Richardson, C, Richardson, J, Ricker, P, Robertson, N, Rollins, J, Roma, V, Romel, C, Romie, J, Rosofsky, S, Ross, M, Sanchez, E, Sanchez, L, Sanders, J, Santiago, K, Saulson, P, Savage, R, Schofield, R, Schulte, B, Schutz, B, Schwalbe, S, Scott, S, Shaddock, D, Shaner, M, Shoemaker, D, Silva, A, Singer, L, Sintes, A, Slagmolen, B, Slaven-Blair, T, Smith, J, Smith, R, Son, E, Spencer, A, Srivastava, A, Steer, D, Stevenson, S, Stops, D, Strain, K, Strigin, S, Stuver, A, Summerscales, T, Sutton, P, Swinkels, B, Szczepanczyk, M, Tait, S, Tanner, D, Tasson, J, Thondapu, S, Thorne, K, Torrie, C, Tringali, M, Tsang, K, Urban, A, Usman, S, Van Bakel, N, Van Beuzekom, M, Van Den Brand, J, Broeck, C, Vander-Hyde, D, Van Heijningen, J, Van Der Schaaf, L, Van Veggel, A, Veitch, P, Viets, A, Vine, D, Vinet, J, Vyatchanin, S, Wade, A, Wade, L, Wang, J, Wang, W, Wang, Y, Ward, R, Warden, Z, Wei, L, Weinstein, A, Wessel, E, Westhouse, J, Whelan, J, Whiting, B, Wilken, D, Williamson, A, Willis, J, Wimmer, M, Wipf, C, Wofford, J, Wright, J, Wysocki, D, Yancey, C, Yap, M, Yeeles, D, Yuen, S, Zadrozny, A, Zendri, J, Zimmerman, A, Zhu, X, Zucker, M, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), (Astro)-Particles Physics, The LIGO Scientific Collaboration, The Virgo Collaboration, IoP (FNWI), and Astroparticle Physics (IHEF, IoP, FNWI)

Subjects
010504 meteorology & atmospheric sciences, data acquisition, Astronomy, 01 natural sciences, black hole, optical, LIGO, gravitational waves, methods: data analysis, gravitational wave, 010303 astronomy & astrophysics, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), Settore FIS/01, astro-ph.HE, Physics, NUCLEOSYNTHESIS, radio wave, COMPACT BINARIES, EJECTION, gravitational waves, neutron stars, Physical Sciences, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, on-line, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, NEUTRON-STAR MERGERS, gamma ray: burst, Astronomy & Astrophysics, X-ray, General Relativity and Quantum Cosmology, SDG 17 - Partnerships for the Goals, RAY BURSTS, 0103 physical sciences, data analysis [methods], STFC, 0105 earth and related environmental sciences, Science & Technology, Gravitational wave, gravitational radiation, Online identification, RCUK, Astronomy and Astrophysics, messenger, Neutron star, VIRGO, electromagnetic, Physics and Astronomy, Space and Planetary Science, RADIATION, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Gamma-ray burst, neutron star: coalescence
Abstract

Advanced LIGO's second observing run (O2), conducted from November 30, 2016 to August 25, 2017, combined with Advanced Virgo's first observations in August 2017 witnessed the birth of gravitational-wave multi-messenger astronomy. The first ever gravitational-wave detection from the coalescence of two neutron stars, GW170817, and its gamma-ray counterpart, GRB 170817A, led to an electromagnetic follow-up of the event at an unprecedented scale. Several teams from across the world searched for EM/neutrino counterparts to GW170817, paving the way for the discovery of optical, X-ray, and radio counterparts. In this article, we describe the online identification of gravitational-wave transients and the distribution of gravitational-wave alerts by the LIGO and Virgo collaborations during O2. We also describe the gravitational-wave observables which were sent in the alerts to enable searches for their counterparts. Finally, we give an overview of the online candidate alerts shared with observing partners during O2. Alerts were issued for 14 candidates, six of which have been confirmed as gravitational-wave events associated with the merger of black holes or neutron stars. Eight of the 14 alerts were issued less than an hour after data acquisition., Comment: 27 pages, 5 figures, 3 tables, accepted for publication in the Astrophysical Journal

Published
2019
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38. The endocannabinoid-alcohol crosstalk: Recent advances on a bi-faceted target

Author

Lavanco, G, Castelli, V, Brancato, A, Tringali, Giuseppe, Plescia, F, Cannizzaro, C., Tringali G (ORCID:0000-0002-1030-9429), Lavanco, G, Castelli, V, Brancato, A, Tringali, Giuseppe, Plescia, F, Cannizzaro, C., and Tringali G (ORCID:0000-0002-1030-9429)

Abstract

Increasing evidence has focusesed on the endocannabinoid system as a relevant player in the induction of aberrant synaptic plasticity and related addictive phenotype following chronic excessive alcohol drinking. In addition, the endocannabinoid system is implicated in the pathogenesis of alcoholic liver disease. Interestingly, whereas the involvement of CB1 receptors in alcohol rewarding properties is established, the central and peripheral action of CB2 signalling is still to be elucidated. This review aims at giving the input to deepen knowledge on the role of the endocannabinoid system, highlighting the advancing evidence that suggests that CB1 and CB2 receptors may play opposite roles in the regulation of both the reinforcing properties of alcohol in the brain and the mechanisms responsible for cell injury and inflammation in the hepatic tissue. The manipulation of the endocannabinoid system could represent a bi-faceted strategy to counteract alcohol-related dysfunction in central transmission and liver structural and functional disarrangement.

Published
2018

44. A survey on knowledge and perceptions regarding head lice on a sample of teachers and students in primary schools of north and south of Italy

Author

SIDOTI, Enza, Bonura, F, Paolini, G, Tringali, G., Sidoti, E, Bonura, F, Paolini, G, and Tringali, G

Subjects
Adult, Male, Health Knowledge, Attitudes, Practice, Schools, Geography, education, Culture, Pediculus, Pediculosis head lice infestation Health Education Primary School, Lice Infestations, Middle Aged, Settore MED/42 - Igiene Generale E Applicata, Faculty, Italy, Scalp Dermatoses, Social Perception, Socioeconomic Factors, Surveys and Questionnaires, Animals, Humans, Female, Public Health, Child, Students, Health Education
Abstract

High rates of pediculosis are found in every part of the world. The age-range most affected is between 3 and 12 years. No-nit policies are ineffective in preventing infestations. On the other hand, misdiagnosis and overuse of pediculicides, increase resistance to treatment. Lack of information leads people to consider this kind of infestation to be associated to low social classes and immigrants. This research has been implemented to find out about the information level on pediculosis on a sample of students (722) and teachers (408) of some primary schools in northern and southern Italy, and to highlight the role of personal aspects such as age, gender, cultural level, geographical position which may influence this topic and, eventually, allow the use of the correct knowledge in developing appropriate procedures within the school district. Data was obtained through a questionnaire containing 21 multiple choice questions for the teachers and 14 for the students. Standard descriptive statistics were computed. ?2 tests were applied to highlight statistical association among observed variables; test for the difference of two proportions were applied to confirm significant differences among the observed proportions. The level of information for students seems to be, approximately, the same both for northern and southern Italy. There was a slight prevalence of correct answers from southern teachers, probably because the phenomenon of pediculosis has a positive trend of growth in the south. The number of correct answers was, for all, on average about 60.0%; a negative result in itself, considering the simplicity of the questions. Knowledge about the biology of the louse was virtually absent. The area of prevention showed lack of information and need for improvement. Most of the teachers believe that there are specific products that can prevent infestation by louse. Most of the teachers have information which does not come from scientific sources. Students receive some short and incomplete information from their parents. Deficiencies in teachers? knowledge indicate that they are inadequately equipped to manage lice infestation. Educational interventions with teachers and families and, as a consequence, with students should be taught at school to allow a correct understanding of the pediculosis, increasing the teachers? competence and, consequently, as soon as the infestation should manifest, a rapid alert of the Health Service so that proper treatment could be provided., Journal of Preventive Medicine and Hygiene, Vol 50, No 3 (2009)

Published
2010

45. Ethanol stimulates corticotropic releasing hormone (CRH) release from rat hypothalamic explants; role of acetaldehyde

Author

CANNIZZARO, Carla, LA BARBERA, Marco, PLESCIA, Fulvio, CACACE, Silvana, TRINGALI, G., CANNIZZARO, C, LA BARBERA, M, PLESCIA, F, CACACE, S, and TRINGALI, G

Subjects
Ethanol, CRH, Settore BIO/14 - Farmacologia, Hypotalamu, acetaldehyde
Abstract

Ethanol is able to activate the hypothalamic-pituitary-adrenal (HPA) axis, and to modify its response to other stressors, releasing adrenocorticotropic hormone (ACTH), and glucocorticoid release, (Lee et al 1999, 2000). In the brain ethanol is diverted by catalase activity into acetaldehyde, which is reported to mediate some of its behavioural and neurochemical effects. (Peana et al 2008, Melis et al 2007) Thus, to clarifìy the mechanisms underlying ethanol activity on the HPA axis we investigated :1) ethanol effect on CRH release from incubated hypothalamic explants; 2) the role of acetaldehyde (ACD), in mediating ethanol activity. To this aim, rat hypothalamic explants were incubated with: 1) medium containing ethanol at 150 mg %; 2) different concentrations of ACD (4.4I, 13.2II, 44III, 132IV x 10-3 mg%); 3) ethanol plus 3-amino-1,2,4-triazole (3-AT, 269 mg%), an inhibitor of cerebral catalase; 4) ACD plus D-penicillamine (D-P, 74.6 mg%), an ACD-trapping agent. CRH levels were evaluated by a radioimmunoassay. Our results show that: incubation with ethanol (150 mg %) induced a significant increase in CRH secretion (p< 0.01); ACD was able to increase CRH release in a dose dependent manner (I=p

Published
2009

46. Ethanol releases corticotropic releasing hormone (CRH) from rat hypothalamic explants; role of acetaldehyde

Author

CANNIZZARO, Carla, LA BARBERA, Marco, PLESCIA, Fulvio, CACACE, Silvana, Tringali, G, Diana, M., Cannizzaro, C, La Barbera, M, Plescia, F, Cacace, S, Tringali, G, and Diana, M

Subjects
Ethanol, CRH, Hypotalamus, Acetaldehyde, Settore BIO/14 - Farmacologia
Abstract

Ethanol activates hypothalamic-pituitary-adrenal (HPA) axis, resulting in adrenocorticotropic hormone (ACTH) glucocorticoid release, and a modification of the response of this axis to other stressors (Lee et al 1999, 2000). To determine the mechanisms responsible for these effects we investigated : 1) whether ethanol was able to release CRH from incubated hypothalamic explants; 2) whether acetaldehyde (ACD), its first metabolite formed in the brain by catalase activity, might play a role in ethanol effects. To this aim, rat hypothalamic explants were incubated with: 1) medium containing ethanol at 150 mg %; 2) different concentrations of ACD (4.4, 13.2, 44, 132 x 10-3 mg%); 3) ethanol plus 3-amino-1,2,4-triazole (3-AT, 269 mg%), an inhibitor of cerebral catalase; 4) ACD plus D-penicillamine (D-P, 74.6 mg%), an ACD-trapping agent. CRH levels were evaluated by a radioimmunoassay. Our results show that: incubation with ethanol (150 mg %) induced a seven-fold increase in CRH secretion (p< 0.01); ACD was able to increase CRH release in a dose dependent manner (p

Published
2009

47. Skin surveillance attitudes and behaviors in relation to skin checks for early signs of skin cancer in a sample of secondary school students and teachers in Palermo, Western Sicily

Author

SIDOTI, Enza, Paolini, G, Tringali, G., Sidoti, E, Paolini, G, and Tringali, G

Subjects
sun exposure, lcsh:Public aspects of medicine, education, lcsh:R, DOAJ:Public Health, lcsh:Medicine, skin self examination, skin cancer prevention, skin cancer prevention, lcsh:RA1-1270, DOAJ:Health Sciences, Skin self examination (SSE)
Abstract

Background: Malignant melanoma (MM) can be readily treated in its earliest stages: survival rate, when detected early, is up to 95,0%. This justifies investigations on contributive factors and measures for precocious detection of skin tumors to improve early detection and to increase survival rates. The purpose of this survey was to collect information about knowledge, attitudes and behaviors on prevention in relation to skin checks for early signs of skin cancer on a sample of secondary school students and teachers.Methods: A sample of secondary school students and teachers from Palermo, was recruited using the clustersampling method. A self-administered questionnaire, consisting of twenty four multiple choice questions was used as the survey instrument. Statistical analysis of data obtained was performed using Openstat software.Results: The research showed a good level of awareness about skin cancer risk factors, which seemed to be strictly correlated with age. On the contrary, practice of skin self-examination (SSE) is not as widespread, and only 4,8% regularly checked the parts of their bodies most exposed to the risk of developing skin cancer. Both students and teachers indicated that school-based health education programs are the best way to promote the importance of prevention.Conclusions: In many countries mortality is not increasing at the same rate as incidence for MM. The practice of SSE may play a vital role in improving early detection and survival rates. Therefore, school interventions to promote knowledge of the benefits of regular SSE should be implemented.

Published
2008

48. Effect of Acetaldehyde on CRF release form incubated hypothalamic explants

Author

CANNIZZARO, Carla, BARRILE, Vita, DILIBERTO, Irene, LA BARBERA, Marco, PLESCIA, Fulvio, PROVENZANO, Giuseppa, TRINGALI, G., CANNIZZARO, C, BARRILE, V, DI LIBERTO, I, LA BARBERA, M, PLESCIA, F, PROVENZANO, G, and TRINGALI, G

Subjects
Ethanol, Settore BIO/14 - Farmacologia, Acetaldehyde, Hypotalamic CRF release
Abstract

In the past, Acetaldehyde (ACD), the main metabolite of ethanol (ETOH), was mainly studied for its toxic and adverse effects (1). However, recently, ACD was reported to determine behavioural and neurochemical effects, following ETOH assumption in rodents (2, 3). Indeed, ACD enhances dopamine levels in nucleus accumbens, stimulates beta-endorphin release from hypothalamic cells, mediating alcohol reinforcing effects (4). Since little is known about the effects of ACD on other central neuropeptides, in this research we aimed to investigate ACD influence on hypothalamic corticotropin-releasing factor (CRF) release. In order to ascertain this hypothesis, different doses of ACD (1, 10, 3x10 microM) have been administered in incubated hypothalamic explants and CRF concentration have been detected by a radioimmunoassay. Our results show that, following 20 min of incubation at 37°C, ACD is able to significantly increase hypothalamic CRF release in a dose-dependent manner (p

Published
2008

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