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28 results on '"Trinei, Mirella"'

8. Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Author

Cosentino, Nicola, primary, Campodonico, Jeness, additional, Pontone, Gianluca, additional, Guglielmo, Marco, additional, Trinei, Mirella, additional, Sandri, Maria Teresa, additional, Riggio, Daniela, additional, Baggiano, Andrea, additional, Milazzo, Valentina, additional, Moltrasio, Marco, additional, Muscogiuri, Giuseppe, additional, Bonomi, Alice, additional, Barbieri, Simone, additional, Assanelli, Emilio, additional, Lauri, Gianfranco, additional, Bartorelli, Antonio, additional, and Marenzi, Giancarlo, additional

Published
2020
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12. Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction

Author

Marenzi, Giancarlo, primary, Cosentino, Nicola, additional, Boeddinghaus, Jasper, additional, Trinei, Mirella, additional, Giorgio, Marco, additional, Milazzo, Valentina, additional, Moltrasio, Marco, additional, Cardinale, Daniela, additional, Sandri, Maria Teresa, additional, Veglia, Fabrizio, additional, Bonomi, Alice, additional, Kaech, Max, additional, Twerenbold, Raphael, additional, Nestelberger, Thomas, additional, Reichlin, Tobias, additional, Wildi, Karin, additional, Shrestha, Samyut, additional, Kohzuharov, Nikola, additional, Sabti, Zaid, additional, Cipolla, Carlo M., additional, Mueller, Christian, additional, and Bartorelli, Antonio L., additional

Published
2016
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13. CIRCULATING CYTOCHROME C IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Author

Cosentino, Nicola, primary, Marenzi, Giancarlo, additional, Trinei, Mirella, additional, Milazzo, Valentina, additional, Moltrasio, Marco, additional, Cardinale, Daniela, additional, Sandri, Maria Teresa, additional, Twerenbold, Raphael, additional, Boeddinghaus, Paul Jasper Simon, additional, Cipolla, Carlo, additional, Mueller, Christian, additional, and Bartorelli, Antonio, additional

Published
2016
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14. The p66Shcknockout mice are short lived under natural condition

Author

Giorgio, Marco, primary, Berry, Alessandra, additional, Berniakovich, Ina, additional, Poletaeva, Inga, additional, Trinei, Mirella, additional, Stendardo, Massimo, additional, Hagopian, Kevork, additional, Ramsey, Jon J., additional, Cortopassi, Gino, additional, Migliaccio, Enrica, additional, Nötzli, Sarah, additional, Amrein, Irmgard, additional, Lipp, Hans P., additional, Cirulli, Francesca, additional, and Pelicci, Pier G., additional

Published
2011
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15. P66Shc signals to age

Author

Trinei, Mirella, primary, Berniakovich, Ina, additional, Beltrami, Elena, additional, Migliaccio, Enrica, additional, Fassina, Ambrogio, additional, Pelicci, PierGiuseppe, additional, and Giorgio, Marco, additional

Published
2009
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19. The Life Span Determinant p66Shc Localizes to Mitochondria Where It Associates with Mitochondrial Heat Shock Protein 70 and Regulates Trans-membrane Potential

Author

Orsini, Francesca, primary, Migliaccio, Enrica, additional, Moroni, Maurizio, additional, Contursi, Cristina, additional, Raker, Veronica A., additional, Piccini, Daniele, additional, Martin-Padura, Ines, additional, Pelliccia, Giovanni, additional, Trinei, Mirella, additional, Bono, Maria, additional, Puri, Claudia, additional, Tacchetti, Carlo, additional, Ferrini, Monica, additional, Mannucci, Roberta, additional, Nicoletti, Ildo, additional, Lanfrancone, Luisa, additional, Giorgio, Marco, additional, and Pelicci, Pier Giuseppe, additional

Published
2004
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24. The p66Shc knocked out mice are short lived under natural condition.

Author

Giorgio, Marco, Berry, Alessandra, Berniakovich, Ina, Poletaeva, Inga, Trinei, Mirella, Stendardo, Massimo, Hagopian, Kevork, Ramsey, Jon J., Cortopassi, Gino, Migliaccio, Enrica, Nötzli, Sarah, Amrein, Irmgard, Lipp, Hans P., Cirulli, Francesca, and Pelicci, Pier G.

Subjects
AGE factors in disease, BODY temperature regulation, ENERGY metabolism, ECOLOGICAL niche, COMPETITION (Biology), REPRODUCTION, LABORATORY mice
Abstract

Summary Deletion of the p66Shc gene results in lean and healthy mice, retards aging, and protects from aging-associated diseases, raising the question of why p66Shc has been selected, and what is its physiological role. We have investigated survival and reproduction of p66Shc−/− mice in a population living in a large outdoor enclosure for a year, subjected to food competition and exposed to winter temperatures. Under these conditions, deletion of p66Shc was strongly counterselected. Laboratory studies revealed that p66Shc−/− mice have defects in fat accumulation, thermoregulation, and reproduction, suggesting that p66Shc has been evolutionarily selected because of its role in energy metabolism. These findings imply that the health impact of targeting aging genes might depend on the specific energetic niche and caution should be exercised against premature conclusions regarding gene functions that have only been observed in protected laboratory conditions. [ABSTRACT FROM AUTHOR]

Published
2012
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26. p66Shc-generated Oxidative Signal Promotes Fat Accumulation.

Author

Berniakovich, Ina, Trinei, Mirella, Stendardo, Massimo, Migliaccio, Enrica, Minucci, Saverio, Bernardi, Paolo, Pelicci, Pier Giuseppe, and Giorgio, Marco

Subjects
*REACTIVE oxygen species, *INSULIN, *ADIPOSE tissues, *ENZYMES, *MITOCHONDRIAL DNA
Abstract

Reactive oxygen species (ROS) and insulin signaling in the adipose tissue are critical determinants of aging and age-associated diseases. It is not clear, however, if they represent independent factors or they are mechanistically linked. We investigated the effects of ROS on insulin signaling using as model system the p66Shc-null mice. p66Shc is a redox enzyme that generates mitochondrial ROS and promotes aging in mammals. We report that insulin activates the redox enzyme activity of p66Shc specifically in adipocytes and that p66Shc-generated ROS regulate insulin signaling through multiple mechanisms, including AKT phosphorylation, Foxo localization, and regulation of selected insulin target genes. Deletion of p66Shc resulted in increased mitochondrial uncoupling and reduced triglyceride accumulation in adipocytes and in vivo increased metabolic rate and decreased fat mass and resistance to diet-induced obesity. In addition, p66Shc-/- mice showed impaired thermo-insulation. These findings demonstrate that p66Shc-generated ROS regulate the effect of insulin on the energetic metabolism in mice and suggest that intracellular oxidative stress might accelerate aging by favoring fat deposition and fat-related disorders. [ABSTRACT FROM AUTHOR]

Published
2008
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27. Mutagenesis of the cyanobacterium Spirulina platensis by UV and nitrosoguanidine treatment

Author

Lanfaloni, Luisa, Trinei, Mirella, Russo, Michele, and Gualerzi, Claudio O.

Abstract

The production of Spirulina platensis cells resistant to 8-azaguanine or β-(2-thienyl)-dl-alanine following mutagenesis with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and UV-irradiation is described. The conditions for the mutagenesis were determined by monitoring cell viability and the appearance of the two types of mutants as a function of the stage of growth of the tricomes and the length and the conditions of the treatment. The optimal conditions for UV and MNNG mutagenesis were found to be 1–3 min irradiation and 30 min incubation with 50 μg MNNG/ml of tricomes derived from cultures entering stationary phase sonicated for 10 s and 5 s respectively. Under these conditions β-(2-thienyl)-dl-alanine-resistant mutants appeared at a frequency ≥10−4 and ≥10−5 following UV- and MNNG-mutagenesis, respectively. Mutants resistant to 8-azaguanine were found at a frequency approx. 10−5 only after MNNG mutagenesis. A few chlorate-resistant mutants were also obtained following UV treatment.

Published
1991
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