1. Elimination of STH morbidity in Zimbabwe: Results of 6 years of deworming intervention for school-age children
- Author
-
Portia Manangazira, Antonio Montresor, Nicholas Midzi, Peter J. Diggle, Claudio Fronterre, Isaac K. Phiri, Masceline Jenipher Mutsaka-Makuvaza, Gibson Mhlanga, Olatunji Johnson, and Santiago, Helton da Costa
- Subjects
Ancylostomatoidea ,Male ,0301 basic medicine ,Ascariasis/epidemiology ,RC955-962 ,Helminthiasis ,Social Sciences ,Anthelmintics/administration & dosage ,Helminthiasis/epidemiology ,Pediatrics ,Geographical Locations ,Deworming ,Families ,Feces ,Soil ,Medical Conditions ,0302 clinical medicine ,Sociology ,Arctic medicine. Tropical medicine ,Epidemiology ,Medicine and Health Sciences ,Prevalence ,Public and Occupational Health ,Child ,Children ,Anthelmintics ,Ascariasis ,Schools ,School age child ,Geography ,Child Health ,Feces/parasitology ,Trichuris ,Infectious Diseases ,Helminth Infections ,Mass Drug Administration ,Regression Analysis ,Female ,Public aspects of medicine ,RA1-1270 ,Ascaris lumbricoides/isolation & purification ,Research Article ,Neglected Tropical Diseases ,medicine.drug ,Zimbabwe ,Trichuris/isolation & purification ,medicine.medical_specialty ,Diagnostic methods ,Adolescent ,Trichuriasis ,030231 tropical medicine ,Albendazole ,Chemoprevention ,Child health ,Education ,Hookworm Infections ,03 medical and health sciences ,Soil/parasitology ,Environmental health ,Zimbabwe/epidemiology ,Parasitic Diseases ,medicine ,Animals ,Humans ,Ascaris lumbricoides ,Mass drug administration ,Ancylostomatoidea/isolation & purification ,Trichuriasis/epidemiology ,Spatial Analysis ,Public Health, Environmental and Occupational Health ,Tropical Diseases ,medicine.disease ,Hookworm Infections/epidemiology ,Health Care ,Albendazole/administration & dosage ,030104 developmental biology ,Soil-Transmitted Helminthiases ,Age Groups ,People and Places ,Africa ,Population Groupings ,Health Statistics ,Morbidity - Abstract
This paper reports the prevalence and intensity of soil-transmitted helminth (STH) infections measured in Zimbabwe before and after a control intervention based on annual deworming of school-age children (SAC) conducted from 2012 to 2018. In 2010, epidemiological data were collected from 13 195 SAC in 255 randomly selected schools in all districts nationwide using, as diagnostic methods, the Kato–Katz and the formal ether stool concentration technique. At follow up, conducted in 2017, only Kato–Katz was performed; specimens were collected from 13 352 children in 336 schools. The data were evaluated using a geospatial approach. The national prevalence of STH infection in SAC was estimated at 5.8% at baseline, with 0.8% of infections of moderate and heavy intensity. Preventive chemotherapy (PC) targeted all 2.5 million children of school age enrolled in Zimbabwe, with coverage ranging from 49% to 85%. At follow up, national prevalence of STH in SAC was estimated at 0.8%; infections of moderate and heavy intensity almost disappeared (0.1% prevalence). As a result, Zimbabwe can suspend deworming activities in 54 districts and reduce the frequency of PC in the remaining six districts. The total amount of albendazole tablets needed will be approximately 100 000 a year., Author summary We analysed the impact of 6 years of preventive chemotherapy intervention by the Ministry of Health and Child Care of Zimbabwe (MoHCC) to control STH infections in Zimbabwe. We applied a geostatistical method to analyse the epidemiological data before and after the intervention. The results are interesting because they demonstrate a complete elimination of infection of moderate heavy intensity (that are considered the ones causing most of STH morbidity and a drastic reduction in prevalence that entails an estimated reduction of 90% in the need for anthelminthic medicines to maintain the situation and a consequent reduction in programme costs.
- Published
- 2020