Search

Your search keyword '"Trezzi, Vittoria"' showing total 13 results
Start Over Author "Trezzi, Vittoria"
13 results on '"Trezzi, Vittoria"'

8. Complex effects of dyslexia risk factors account for ADHD-traits : evidence from two independent samples

Author

Mascheretti, Sara, Trezzi, Vittoria, Giorda, Roberto, Dionne, Ginette, Plourde, Vickie, Vitaro, Frank, Brendgen, Mara Rosemarie, Boivin, Michel, Marino, Cecilia, Mascheretti, Sara, Trezzi, Vittoria, Giorda, Roberto, Dionne, Ginette, Plourde, Vickie, Vitaro, Frank, Brendgen, Mara Rosemarie, Boivin, Michel, and Marino, Cecilia

Abstract

Background : Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (GxG and GxE, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1 and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status and parental education) for main, either 1) genetic or 2) environmental, 3) G×G, and 4) G×E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. Methods : Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. GxG were investigated by a general linear model equation and a family-based association test. GxE were analyzed through a general test for GxE in sib-pair-based association analysis of quantitative traits. Results: DCDC2-rs793862 was associated with hyperactivity/impulsivity via G×G (KIAA0319) and G×E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2×KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. Conclusions : DD genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD-traits supporting a potential pleiotropic effect.

Published
2016

12. The role of READ1 and KIAA0319genetic variations in developmental dyslexia: testing main and interactive effects

Author

Trezzi, Vittoria, Forni, Diego, Giorda, Roberto, Villa, Marco, Molteni, Massimo, Marino, Cecilia, and Mascheretti, Sara

Abstract

Developmental dyslexia (DD) is a complex heritable condition characterized by impaired reading abilities. Two well-replicated candidate risk factors are as follows: (1) regulatory element associated with dyslexia 1 (READ1), which is located in intron 2 of DCDC2and acts as a binding site for protein regulation of DCDC2expression; and (2) a three-single-nucleotide polymorphism risk haplotype spanning KIAA0319. Phylogenetically similar READ1 variants showed synergistic effects with the KIAA0319risk haplotype on reading-related phenotypes in a general population sample. Here we examine the association between different allele classes in READ1, the KIAA0319risk haplotype and reading-related traits in a cohort of 368 Italian children with DD and their siblings (n=266) by testing both main and non-additive effects. We replicated the deleterious main effects upon both reading accuracy and speed exerted by the longer READ1 alleles. We further supported the interdependence through non-additive, possibly antagonistic, effects between READ1 and the KIAA0319risk haplotype on reading accuracy. By suggesting the presence of common biological processes underlying reading (dis)ability, these findings represent initial support for a generalist effect of the non-additive interdependence between READ1 and the KIAA0319risk haplotype. Moreover, our results confirm that using as much information as possible about genetic interdependence among dyslexia-candidate genes can help in clinically assessing the individual risk for DD.

Published
2017
Full Text
View/download PDF

13. GRIN2Bmediates susceptibility to intelligence quotient and cognitive impairments in developmental dyslexia

Author

Mascheretti, Sara, Facoetti, Andrea, Giorda, Roberto, Beri, Silvana, Riva, Valentina, Trezzi, Vittoria, Cellino, Maria R., and Marino, Cecilia

Abstract

Developmental dyslexia (DD) is a complex heritable condition associated with impairments in multiple neurocognitive domains. Substantial heritability has been reported for DD and related phenotypes, and candidate genes have been identified. Recently, a candidate gene for human cognitive processes, that is, GRIN2B, has been found to be associated significantly with working memory in a German DD sample. In this study, we explored the contribution of six GRIN2Bmarkers to DD and key DD-related phenotypes by association analyses in a sample of Italian nuclear families. Moreover, we assessed potential gene-by-environment interactions on DD-related phenotypes.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results