3,025 results on '"Trezza, A"'
Search Results
2. Learning effective good variables from physical data
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Barletta, Giulio, Trezza, Giovanni, and Chiavazzo, Eliodoro
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Physics - Data Analysis, Statistics and Probability ,Computer Science - Machine Learning - Abstract
We assume that a sufficiently large database is available, where a physical property of interest and a number of associated ruling primitive variables or observables are stored. We introduce and test two machine learning approaches to discover possible groups or combinations of primitive variables: The first approach is based on regression models whereas the second on classification models. The variable group (here referred to as the new effective good variable) can be considered as successfully found, when the physical property of interest is characterized by the following effective invariant behaviour: In the first method, invariance of the group implies invariance of the property up to a given accuracy; in the other method, upon partition of the physical property values into two or more classes, invariance of the group implies invariance of the class. For the sake of illustration, the two methods are successfully applied to two popular empirical correlations describing the convective heat transfer phenomenon and to the Newton's law of universal gravitation., Comment: 24 pages (main), 8 pages (suppi), 12 figures (main), 3 figures (suppi)
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- 2024
3. Classification-based detection and quantification of cross-domain data bias in materials discovery
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Trezza, Giovanni and Chiavazzo, Eliodoro
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Condensed Matter - Other Condensed Matter ,Computer Science - Machine Learning - Abstract
It stands to reason that the amount and the quality of data is of key importance for setting up accurate AI-driven models. Among others, a fundamental aspect to consider is the bias introduced during sample selection in database generation. This is particularly relevant when a model is trained on a specialized dataset to predict a property of interest, and then applied to forecast the same property over samples having a completely different genesis. Indeed, the resulting biased model will likely produce unreliable predictions for many of those out-of-the-box samples. Neglecting such an aspect may hinder the AI-based discovery process, even when high quality, sufficiently large and highly reputable data sources are available. In this regard, with superconducting and thermoelectric materials as two prototypical case studies in the field of energy material discovery, we present and validate a new method (based on a classification strategy) capable of detecting, quantifying and circumventing the presence of cross-domain data bias., Comment: 27 pages, 7 figures (main), 4 figures (supp info)
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- 2023
4. Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats
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Girella, Antonio, Di Bartolomeo, Martina, Dainese, Enrico, Buzzelli, Valeria, Trezza, Viviana, and D’Addario, Claudio
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- 2024
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5. An Add-on Model Predictive Control Strategy for the Energy Management of Hybrid Electric Tractors
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Radrizzani, Stefano, Panzani, Giulio, Trezza, Luca, Pizzocaro, Solomon, and Savaresi, Sergio M.
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Electrical Engineering and Systems Science - Systems and Control - Abstract
The hybridization process has recently touched also the world of agricultural vehicles. Within this context, we develop an Energy Management Strategy (EMS) aiming at optimizing fuel consumption, while maintaining the battery state of charge. A typical feature of agricultural machines is that their internal combustion engine is speed controlled, tracking the reference requested by the driver. In view of avoiding any modification on this original control loop, an add-on EMS strategy is proposed. In particular, we employ a multi-objective Model Predictive Control (MPC), taking into account the fuel consumption minimization and the speed tracking requirement, including the engine speed controller in the predictive model. The proposed MPC is tested in an experimentally-validated simulation environment, representative of an orchard vineyard tractor., Comment: Accepted for publication on IEEE Transactions on Vehicular Technology
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- 2023
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6. The Subordination of Teaching to Learning: Teacher Adaptability and Awareness
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Vanessa Asencio-Trezza
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In today's context of schooling, most teaching is aimed at output, coverage, and high scores which is in direct contrast to what pre-service teachers are taught to cherish -- differentiation, academic choice, and student autonomy. However, there is an approach that shows promise in counteracting the tendency to over stress scores and undermine a humanizing approach to teaching and learning. Called the Subordination of Teaching to Learning (SubTLe), this approach potentially alleviates the tension between long established, highly valued learning outcomes and the unavoidable pressures of high stakes testing but has yet to be studied in this context. Founded by Caleb Gattegno (1911-1988) SubTLe, as a practice, is defined in this study as teaching that is guided by learning. As a theory, the Subordination of Teaching to Learning derives from Gattegno's assertion that "only awareness is educable" (defined later) in humans (Gattegno, 1987). Using that assertion as its foundation, this dissertation explores what happens when teachers pay attention to -- and carefully reflect on -- their own learning and its implications for responding to and being guided by their students' learning and, through reflective practices, thereby educate their own awareness of themselves as learners. The results of the study indicate that, while it is challenging to attend to one's own learning in the act of teaching, it is nevertheless possible, through structured reflection, to gain insight into one's own inner movements, habits, and inclinations. Evidence shows that disciplined, structured conversations about what they can learn about themselves in the act of teaching increases teachers' awareness of themselves as learners, which in turn increases their capacity to more skillfully adapt to and be guided by the learning of their students. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2024
7. Analysis of busbar arrangements in substations: A methodological approach
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Gomes, Larisa Alves, primary, Monteiro, Paulo Roberto Duailibe, additional, and Borges, Thiago Trezza, additional
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- 2024
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8. Deterministic Multi-sensor Measurement-adaptive Birth using Labeled Random Finite Sets
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Bondarchuk, Jennifer, Trezza, Anthony, and Bucci Jr, Donald J.
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Electrical Engineering and Systems Science - Signal Processing ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Measurement-adaptive track initiation remains a critical design requirement of many practical multi-target tracking systems. For labeled random finite sets multi-object filters, prior work has been established to construct a labeled multi-object birth density using measurements from multiple sensors. A truncation procedure has also been provided that leverages a stochastic Gibbs sampler to truncate the birth density for scalability. In this work, we introduce a deterministic herded Gibbs sampling truncation solution for efficient multi-sensor adaptive track initialization. Removing the stochastic behavior of the track initialization procedure without impacting average tracking performance enables a more robust tracking solution more suitable for safety-critical applications. Simulation results for linear sensing scenarios are provided to verify performance., Comment: Accepted to the 2023 Proc. IEEE 26th Int. Conf. Inf. Fusion
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- 2023
9. On Gibbs Sampling Architecture for Labeled Random Finite Sets Multi-Object Tracking
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Trezza, Anthony, Bucci Jr., Donald J., and Varshney, Pramod K.
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Electrical Engineering and Systems Science - Systems and Control ,Electrical Engineering and Systems Science - Signal Processing - Abstract
Gibbs sampling is one of the most popular Markov chain Monte Carlo algorithms because of its simplicity, scalability, and wide applicability within many fields of statistics, science, and engineering. In the labeled random finite sets literature, Gibbs sampling procedures have recently been applied to efficiently truncate the single-sensor and multi-sensor $\delta$-generalized labeled multi-Bernoulli posterior density as well as the multi-sensor adaptive labeled multi-Bernoulli birth distribution. However, only a limited discussion has been provided regarding key Gibbs sampler architecture details including the Markov chain Monte Carlo sample generation technique and early termination criteria. This paper begins with a brief background on Markov chain Monte Carlo methods and a review of the Gibbs sampler implementations proposed for labeled random finite sets filters. Next, we propose a short chain, multi-simulation sample generation technique that is well suited for these applications and enables a parallel processing implementation. Additionally, we present two heuristic early termination criteria that achieve similar sampling performance with substantially fewer Markov chain observations. Finally, the benefits of the proposed Gibbs samplers are demonstrated via two Monte Carlo simulations., Comment: Accepted to the 2023 Proc. IEEE 26th Int. Conf. Inf. Fusion
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- 2023
10. Exoscopic microneurosurgery in pediatric brain tumors: an ideal tool for complex and peculiar anatomo-topographic scenarios?
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Trezza, Andrea, de Laurentis, Camilla, Carrabba, Giorgio Giovanni, Massimino, Maura, Biassoni, Veronica, Doro, Arianna, Vimercati, Chiara, and Giussani, Carlo Giorgio
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- 2024
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11. Leveraging Composition-Based Material Descriptors for Machine Learning Optimization
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Trezza, Giovanni and Chiavazzo, Eliodoro
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Condensed Matter - Other Condensed Matter - Abstract
In this study, we evaluate several classifiers and focus on selecting a minimal set of appropriate material features. Our objective is to propose and discuss general strategies for reducing the number of descriptors required for material classification. The first strategy involves testing whether the critical temperature of the target material property is invariant with respect to binary groups of composition-based features. We also propose a multi-objective optimization procedure to reduce the set of composition-based material descriptors. The latter procedure is found to be particularly useful when applied to Bayesian classifiers. We test the proposed strategies focusing on low-temperature superconductors material data extracted from a public database., Comment: 34 pages, 11 figure panels in the main document, 5 figure panels in the supp. info, preprint
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- 2023
12. Learning Effective Good Variables from Physical Data
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Giulio Barletta, Giovanni Trezza, and Eliodoro Chiavazzo
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machine learning in physics ,primitive variable analysis ,physical property invariance ,feature grouping ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
We assume that a sufficiently large database is available, where a physical property of interest and a number of associated ruling primitive variables or observables are stored. We introduce and test two machine learning approaches to discover possible groups or combinations of primitive variables, regardless of data origin, being it numerical or experimental: the first approach is based on regression models, whereas the second on classification models. The variable group (here referred to as the new effective good variable) can be considered as successfully found when the physical property of interest is characterized by the following effective invariant behavior: in the first method, invariance of the group implies invariance of the property up to a given accuracy; in the other method, upon partition of the physical property values into two or more classes, invariance of the group implies invariance of the class. For the sake of illustration, the two methods are successfully applied to two popular empirical correlations describing the convective heat transfer phenomenon and to the Newton’s law of universal gravitation.
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- 2024
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13. Exploring the Dietary, Lifestyle, and Demographic Factors Associated with Risk for Colorectal Cancer and Colorectal Abnormalities in a Fecal Immunochemical Test-Positive Population: A Cross-Sectional Study in the Kingdom of Bahrain
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Omar Sharif, Afnan Freije, Salwa Al-Thawadi, Dalal Alromaihi, Fida Alsaffar, Essam Juma, Faisal Abubaker, Abdulrahman Barakat, Mariam Alhammadi, Zeyad Mahmood, Suha Hejres, Hanan Matar, Alice Trezza, Mariangela Rondanelli, and Simone Perna
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colon cancer ,Bahrain ,diet ,screening ,fit colorectal cancer ,fecal immunochemical test ,Medicine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Objectives: Colorectal cancer incidence in Bahrain occurs at a ratio of 13.4–18.8 per 100,000 persons after age standardization. This study aims to explore the relationship between colorectal cancer/abnormalities and different lifestyle factors. Secondly, it aims to explore the association between f-Hb levels, colonoscopy findings, and lifestyle factors in a FIT-positive population in Bahrain. Method: A retrospective cross-sectional study was performed for patients positive for FIT and who had a colonoscopy. Different dietary and demographic factors as well as f-Hb levels were assessed. Results: A total of 559 (M: 330; F: 229) subjects were enrolled in this study. Subjects with CRC had significantly higher f-Hb concentrations (median: 1269 μg/mg) when compared with subjects of other groups. Higher percentages of CRC as well as large and small polyps were recorded in males. However, there was no significant difference in f-Hb concentration between males and females (p = 0.90). Higher median levels were found for f-Hb in patients with Q3 (higher red meat consumption) compared to Q1 and Q2 in the category with CRC, despite there being no statistically significant differences among the groups (p = 0.742). Similar results for coffee consumption and f-Hb concentrations in the different groups have been recorded (p = 0.697). A higher quartile of red meat consumption was associated with an increase in CRC risk of 79.9%. Coffee consumption reflected a lower risk of CRC by −47% moving from Q1 to Q2, while BMI was found to be a risk factor (+44%) for CRC. Conclusion: This study highlighted that high f-Hb concentration can be used as a predictive biomarker of CRC.
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- 2024
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14. Effect of different carbonate fillers on the durability of mortars
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Di Salvo Barsi, Antonela, Cordoba, Gisela, Trezza, Mónica A., and Irassar, Edgardo F.
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- 2024
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15. An innovative approach: Agile methodologies for the design of power circuit breakers
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Monteiro, Paulo Roberto Duailibe, primary, Borges, Thiago Trezza, additional, and Schiochet, André Fernando, additional
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- 2024
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16. From Microscopic to Exoscopic Microsurgery: Are We Facing a Change of Paradigm?
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Di Cristofori, Andrea, de Laurentis, Camilla, Trezza, Andrea, Ramponi, Alberto, Carrabba, Giorgio, Giussani, Carlo, Di Rocco, Concezio, Series Editor, Arraez, Miguel A., Editorial Board Member, Boop, Frederick A., Editorial Board Member, Froelich, Sebastien, Editorial Board Member, Kato, Yoko, Editorial Board Member, Pang, Dachling, Editorial Board Member, and Tu, Yong-Kwang, Editorial Board Member
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- 2024
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17. Considerations on very early management of endoscopic third ventriculostomy in children with posterior fossa tumors
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Trezza, Andrea, Carrabba, Giorgio Giovanni, Meletti, Liliana, Di Cristofori, Andrea, and Giussani, Carlo Giorgio
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- 2024
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18. Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
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D’Antoni, Simona, Schiavi, Sara, Buzzelli, Valeria, Giuffrida, Samuele, Feo, Alessandro, Ascone, Fabrizio, Busceti, Carla Letizia, Nicoletti, Ferdinando, Trezza, Viviana, and Catania, Maria Vincenza
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- 2023
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19. An Add-On Model Predictive Control Strategy for the Energy Management of Hybrid Electric Tractors.
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Stefano Radrizzani, Giulio Panzani, Luca Trezza, Solomon Pizzocaro, and Sergio M. Savaresi
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- 2024
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20. Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex
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Francesca Mottarlini, Beatrice Rizzi, Giorgia Targa, Valeria Buzzelli, Melania Di Trapano, Laura Rullo, Sanzio Candeletti, Roberto Ciccocioppo, Liana Fattore, Patrizia Romualdi, Fabio Fumagalli, Viviana Trezza, and Lucia Caffino
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communal nesting ,early-life stress ,social isolation ,NMDA receptors ,prefrontal cortex ,sex difference ,Psychiatry ,RC435-571 - Abstract
IntroductionEarly social environment, either positive or negative, shapes the adult brain. Communal nesting (CN), a naturalistic setting in which 2-3 females keep their pups in a single nest sharing care-giving behavior, provides high level of peer interaction for pups. Early social isolation (ESI) from dam and siblings represents, instead, an adverse condition providing no peer interaction.MethodsWe investigated whether CN (enrichment setting) might influence the response to ESI (impoverishment setting) in terms of social behavior and glutamate system in the medial prefrontal cortex (mPFC) of adult and adolescent male and female rats.ResultsPinning (a rewarding component of social play behavior) was significantly more pronounced in males than in females exposed to the combination of CN and ESI. CN sensitized the glutamate synapse in the mPFC of ESI-exposed male, but not female, rats. Accordingly, we observed (i) a potentiation of the glutamatergic neurotransmission in the mPFC of both adolescent and adult males, as shown by the recruitment of NMDA receptor subunits together with increased expression/activation of PSD95, SynCAM 1, Synapsin I and αCaMKII; (ii) a de-recruiting of NMDA receptors from active synaptic zones of same-age females, together with reduced expression/activation of the above-mentioned proteins, which might reduce the glutamate transmission. Whether similar sex-dependent glutamate homeostasis modulation occurs in other brain areas remains to be elucidated.DiscussionCN and ESI interact to shape social behavior and mPFC glutamate synapse homeostasis in an age- and sex-dependent fashion, suggesting that early-life social environment may play a crucial role in regulating the risk to develop psychopathology.
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- 2024
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21. Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors
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Antonia Manduca, Valeria Buzzelli, Alessandro Rava, Alessandro Feo, Emilia Carbone, Sara Schiavi, Barbara Peruzzi, Valentina D’Oria, Marco Pezzullo, Andrea Pasquadibisceglie, Fabio Polticelli, Vincenzo Micale, Martin Kuchar, and Viviana Trezza
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Cannabidiol ,Fragile X syndrome ,GPR55 receptors ,Fatty acid amide hydrolase ,Cognitive performance ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Cannabidiol (CBD), a non-psychotomimetic constituent of Cannabis sativa, has been recently approved for epileptic syndromes often associated with Autism spectrum disorder (ASD). However, the putative efficacy and mechanism of action of CBD in patients suffering from ASD and related comorbidities remain debated, especially because of the complex pharmacology of CBD. We used pharmacological, immunohistochemical and biochemical approaches to investigate the effects and mechanisms of action of CBD in the recently validated Fmr1-Δexon 8 rat model of ASD, that is also a model of Fragile X Syndrome (FXS), the leading monogenic cause of autism. CBD rescued the cognitive deficits displayed by juvenile Fmr1-Δexon 8 animals, without inducing tolerance after repeated administration. Blockade of CA1 hippocampal GPR55 receptors prevented the beneficial effect of both CBD and the fatty acid amide hydrolase (FAAH) inhibitor URB597 in the short-term recognition memory deficits displayed by Fmr1-Δexon 8 rats. Thus, CBD may exert its beneficial effects through CA1 hippocampal GPR55 receptors. Docking analysis further confirmed that the mechanism of action of CBD might involve competition for brain fatty acid binding proteins (FABPs) that deliver anandamide and related bioactive lipids to their catabolic enzyme FAAH. These findings demonstrate that CBD reduced cognitive deficits in a rat model of FXS and provide initial mechanistic insights into its therapeutic potential in neurodevelopmental disorders.
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- 2024
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22. The MAP3K7 gene: Further delineation of clinical characteristics and genotype/phenotype correlations.
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van Bon, Bregje, Brooks, Alice, Guan, Qiaoning, Klee, Eric, Marcelis, Carlo, Rosado, Joel, Schimmenti, Lisa, Shikany, Amy, Terhal, Paulien, Nicole Weaver, Kathryn, Wessels, Marja, van Wieringen, Hester, Hurst, Anna, Gooch, Catherine, Steindl, Katharina, Joset, Pascal, Rauch, Anita, Tartaglia, Marco, Niceta, Marcello, Elgersma, Ype, Demirdas, Serwet, van Woerden, Geeske, Senden, Richelle, de Konink, Charlotte, Trezza, Rossella, Baban, Anwar, Bassetti, Jennifer, van Bever, Yolande, and Bird, Lynne
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MAP3K7 ,Noonan syndrome ,cardiospondylocarpofacial syndrome ,frontometaphyseal dysplasia type 2 ,Abnormalities ,Multiple ,Genotype ,Hearing Loss ,Bilateral ,Humans ,Mitral Valve Insufficiency ,Mutation ,Noonan Syndrome ,Osteosclerosis ,Phenotype - Abstract
Mitogen-activated protein 3 kinase 7 (MAP3K7) encodes the ubiquitously expressed transforming growth factor β-activated kinase 1, which plays a crucial role in many cellular processes. Mutationsin the MAP3K7 gene have been linked to two distinct disorders: frontometaphyseal dysplasia type 2 (FMD2) and cardiospondylocarpofacial syndrome (CSCF). The fact that different mutations can induce two distinct phenotypes suggests a phenotype/genotype correlation, but no side-by-side comparison has been done thus far to confirm this. Here, we significantly expand the cohort and the description of clinical phenotypes for patients with CSCF and FMD2 who carry mutations in MAP3K7. Our findings support that in contrast to FMD2-causing mutations, CSCF-causing mutations in MAP3K7 have a loss-of-function effect. Additionally, patients with pathogenic mutations in MAP3K7 are at risk for (severe) cardiac disease, have symptoms associated with connective tissue disease, and we show overlap in clinical phenotypes of CSCF with Noonan syndrome (NS). Together, we confirm a molecular fingerprint of FMD2- versus CSCF-causing MAP3K7 mutations and conclude that mutations in MAP3K7 should be considered in the differential diagnosis of patients with syndromic congenital cardiac defects and/or cardiomyopathy, syndromic connective tissue disorders, and in the differential diagnosis of NS.
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- 2022
23. Minimal set of crystallographic descriptors for sorption properties in hypothetical Metal Organic Frameworks: Role in sequential learning optimization
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Trezza, Giovanni, Bergamasco, Luca, Fasano, Matteo, and Chiavazzo, Eliodoro
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Condensed Matter - Other Condensed Matter - Abstract
Several studies have been recently reported in the literature on sorption properties of MOFs with a number of organic sorbates, such as ethanol and methanol. Surprisingly, still few studies have been reported on water sorbate despite its large availability, low cost and environmental sustainability, and the screening of a large number of hypothetical MOFs-water working pairs for engineering applications is still challenging. Based on a recently reported database of over 5000 hypothetical MOFs, a first contribution of this study is the identification of the minimal set of crystallographic descriptors underpinning the most important sorption properties of MOFs for \ch{CO2} and, importantly, for \ch{H2O}. Furthermore, a comprehensive comparison of several Sequential Learning (SL) algorithms for MOFs properties optimization is carried out and the role played by the above minimal set of crystallographic descriptors clarified. In sorption-based energy transformations, thermodynamic limits of important figures of merit (e.g. maximum specific energy) depend both on operating conditions and equilibrium sorption properties in a wide range of sorbate coverage values. The access to the latter properties is often incomplete, with essential quantities such as equilibrium adsorption isotherms spanning over the full sorbate coverage range and values of the isosteric heat being only partially available. As a result, this may prevent the computation of objective functions during the optimization procedure. We propose a fast procedure for optimizing specific energy in a closed sorption energy storage system with the only access to the water Henry coefficient at a fixed temperature value and to the specific surface area., Comment: 27 pages (main) and 16 pages (Supp. Info). 13 figures in the main text. To be submitted to Nature computational materials
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- 2021
24. Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy
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Luisa Frusciante, Michela Geminiani, Behnaz Shabab, Tommaso Olmastroni, Giorgia Scavello, Martina Rossi, Pierfrancesco Mastroeni, Collins Nyaberi Nyong’a, Laura Salvini, Stefania Lamponi, Maria Laura Parisi, Adalgisa Sinicropi, Lorenzo Costa, Ottavia Spiga, Alfonso Trezza, and Annalisa Santucci
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circular bioeconomy ,Crocus sativus ,Saccharomyces cerevisiae ,RAW 264.7 ,antioxidant ,anti-inflammatory ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Repurposing saffron (Crocus sativus) waste presents a sustainable strategy for generating high-value products within the bioeconomy framework. Typically, flower components are discarded after stigma harvest, resulting in significant waste—350 kg of tepals per kilogram of stigmas. This research employed a comprehensive approach, integrating bioactivity studies (in vitro and in silico) with Life Cycle Assessment (LCA) evaluations, to extract and assess bioactive compounds from C. sativus tepals sourced in Tuscany, Italy. Phytochemical characterization using UPLC-MS/MS revealed a high abundance and variety of flavonoids in the hydro-ethanolic extract (CST). The antioxidant capacity was validated through various assays, and the ability to mitigate H2O2-induced oxidative stress and enhance fermentation was demonstrated in Saccharomyces cerevisiae. This study reports that C. sativus tepals extract reduces oxidative stress and boosts ethanol fermentation in yeast, paving the way for applications in the food and biofuels sectors. Further validation in RAW 264.7 macrophages confirmed CST’s significant anti-inflammatory effects, indicating its potential for pharmaceutical, cosmeceutical, and nutraceutical applications. In silico studies identified potential targets involved in antioxidant and anti-inflammatory processes, shedding light on possible interaction mechanisms with Kaempferol 3-O-sophoroside (KOS-3), the predominant compound in the extract. The integration of LCA studies highlighted the environmental benefits of this approach. Overall, this research underscores the value of using waste-derived extracts through “green” methodologies, offering a model that may provide significant advantages for further evaluations compared to traditional methodologies and supporting the circular bioeconomy.
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- 2024
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25. HGA Triggers SAA Aggregation and Accelerates Fibril Formation in the C20/A4 Alkaptonuria Cell Model
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Pierfrancesco Mastroeni, Alfonso Trezza, Michela Geminiani, Luisa Frusciante, Anna Visibelli, and Annalisa Santucci
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alkaptonuria ,secondary amyloidosis ,amyloid ,metabolic disease ,serum amyloid A ,serum amyloid P ,Cytology ,QH573-671 - Abstract
Alkaptonuria (AKU) is a rare autosomal recessive metabolic disorder caused by mutations in the homogentisate 1,2-dioxygenase (HGD) gene, leading to the accumulation of homogentisic acid (HGA), causing severe inflammatory conditions. Recently, the presence of serum amyloid A (SAA) has been reported in AKU tissues, classifying AKU as novel secondary amyloidosis; AA amyloidosis is characterized by the extracellular tissue deposition of fibrils composed of fragments of SAA. AA amyloidosis may complicate several chronic inflammatory conditions, like rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, chronic infections, neoplasms, etc. Treatments of AA amyloidosis relieve inflammatory disorders by reducing SAA concentrations; however, no definitive therapy is currently available. SAA regulation is a crucial step to improve AA secondary amyloidosis treatments. Here, applying a comprehensive in vitro and in silico approach, we provided evidence that HGA is a disruptor modulator of SAA, able to enhance its polymerization, fibril formation, and aggregation upon SAA/SAP colocalization. In silico studies deeply dissected the SAA misfolding molecular pathway and SAA/HGA binding, suggesting novel molecular insights about it. Our results could represent an important starting point for identifying novel therapeutic strategies in AKU and AA secondary amyloidosis-related diseases.
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- 2024
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26. Multi-sensor Joint Adaptive Birth Sampler for Labeled Random Finite Set Tracking
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Trezza, Anthony, Bucci Jr., Donald J., and Varshney, Pramod K.
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Electrical Engineering and Systems Science - Signal Processing ,Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper provides a scalable, multi-sensor measurement adaptive track initiation technique for labeled random finite set filters. A naive construction of the multi-sensor measurement adaptive birth set distribution leads to an exponential number of newborn components in the number of sensors. A truncation criterion is established for a labeled multi-Bernoulli random finite set birth density. The proposed truncation criterion is shown to have a bounded L1 error in the generalized labeled multi-Bernoulli posterior density. This criterion is used to construct a Gibbs sampler that produces a truncated measurement-generated labeled multi-Bernoulli birth distribution with quadratic complexity in the number of sensors. A closed-form solution of the conditional sampling distribution assuming linear Gaussian likelihoods is provided, alongside an approximate solution using Monte Carlo importance sampling. Multiple simulation results are provided to verify the efficacy of the truncation criterion, as well as the reduction in complexity.
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- 2021
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27. Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors
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Manduca, Antonia, Buzzelli, Valeria, Rava, Alessandro, Feo, Alessandro, Carbone, Emilia, Schiavi, Sara, Peruzzi, Barbara, D’Oria, Valentina, Pezzullo, Marco, Pasquadibisceglie, Andrea, Polticelli, Fabio, Micale, Vincenzo, Kuchar, Martin, and Trezza, Viviana
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- 2024
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28. Boosting teamwork between scrub nurses and neurosurgeons: exploring the value of a role-played hands-on, cadaver-free simulation and systematic review of the literature
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Camilla de Laurentis, David Pirillo, Andrea Di Cristofori, Alessandro Versace, Tommaso Calloni, Andrea Trezza, Valentina Villa, Lucia Alberti, Angelo Baldo, Federico Nicolosi, Giorgio Carrabba, and Carlo Giussani
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education ,interprofessional ,non-technical skills ,operating room ,roleplay ,simulation ,Surgery ,RD1-811 - Abstract
BackgroundRecently, non-technical skills (NTS) and teamwork in particular have been demonstrated to be essential in many jobs, in business as well as in medical specialties, including plastic, orthopedic, and general surgery. However, NTS and teamwork in neurosurgery have not yet been fully studied. We reviewed the relevant literature and designed a mock surgery to be used as a team-building activity specifically designed for scrub nurses and neurosurgeons.MethodsWe conducted a systematic review by searching PubMed (Medline) and CINAHL, including relevant articles in English published until 15 July 2023. Then, we proposed a pilot study consisting of a single-session, hands-on, and cadaver-free activity, based on role play. Scrub nurses were administered the SPLINTS (Scrub Practitioners’ List of Intraoperative Non-Technical Skills) rating form as a self-evaluation at baseline and 20–30 days after the simulation. During the experiment, surgeons and scrub nurses role-played as each other, doing exercises including a simulated glioma resection surgery performed on an advanced model of a cerebral tumor (Tumor Box, UpSurgeOn®) under an exoscope. At the end, every participant completed an evaluation questionnaire.ResultsA limited number of articles are available on the topic. This study reports one of the first neurosurgical team-building activities in the literature. All the participating scrub nurses and neurosurgeons positively evaluated the simulation developed on a roleplay. The use of a physical simulator seems an added value, as the tactile feedback given by the model further helps to understand the actual surgical job, more than only observing and assisting. The SPLINTS showed a statistically significant improvement not only in “Communication and Teamwork” (p = 0.048) but also in “Situation Awareness” (p = 0.031).ConclusionOur study suggests that team-building activities may play a role in improving interprofessional teamwork and other NTS in neurosurgery.
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- 2024
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29. Editorial: Innovative approaches and therapeutic perspectives for early-onset neurodevelopmental disorders: from bench to bedside
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Barbara Bardoni, Maria Vincenza Catania, and Viviana Trezza
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neurodevelopmental disorders ,Fragile X Syndrome ,Down Syndrome ,Rett Syndrome ,Shank3a ,Prader Willi Syndrome ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2024
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30. Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
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Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat, Clara Sanchez, Alessandra Tempio, Andrei Turtoi, Mauro Giorgi, Sandra Lacas-Gervais, Gabriele Baj, Carole Rovere, Viviana Trezza, Manuela Pellegrini, Thomas Maurin, Enzo Lalli, and Barbara Bardoni
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cAMP and cGMP pathways ,PDE2A ,Autism Spectrum disorder ,Intellectual disability ,Mouse model ,mGluR-dependent LTD ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Phosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS. While the pharmacological inhibition of PDE2A has been associated to its pro-cognitive role in normal animals and in models of ID and ASD, homozygous PDE2A mutations have been identified in patients affected by ID, ASD and epilepsy. To clarify this apparent paradox about the role of PDE2A in brain development, we characterized here Pde2a+/− mice (homozygote animals being not viable) at the behavioral, cellular, molecular and electrophysiological levels. Pde2a+/− females display a milder form of the disorder with reduced cognitive performance in adulthood, conversely males show severe socio-cognitive deficits throughout their life. In males, these phenotypes are associated with microglia activation, elevated glutathione levels and increased externalization of Glutamate receptor (GluR1) in CA1, producing reduced mGluR-dependent Long-term Depression. Overall, our results reveal molecular targets of the PDE2A-dependent pathway underlying socio-cognitive performance. These results clarify the mechanism of action of pro-cognitive drugs based on PDE2A inactivation, which have been shown to be promising therapeutic approaches for Alzheimer's disease, schizophrenia, FXS as well as other forms of ASD.
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- 2024
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31. Connecting offshore wind farms to the electric power system: A brief overview
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Carvalho, Paulo Fernando Santos Dias de, primary, Schiochet, André Fernando, additional, Rocha, Leonardo de Carvalho, additional, Borges, Thiago Trezza, additional, and Monteiro, Paulo Roberto Duailibe, additional
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- 2023
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32. Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats
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Schiavi, Sara, Manduca, Antonia, Carbone, Emilia, Buzzelli, Valeria, Rava, Alessandro, Feo, Alessandro, Ascone, Fabrizio, Morena, Maria, Campolongo, Patrizia, Hill, Matthew N., and Trezza, Viviana
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- 2023
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33. Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a
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Delhaye, Sébastien, Jarjat, Marielle, Boulksibat, Asma, Sanchez, Clara, Tempio, Alessandra, Turtoi, Andrei, Giorgi, Mauro, Lacas-Gervais, Sandra, Baj, Gabriele, Rovere, Carole, Trezza, Viviana, Pellegrini, Manuela, Maurin, Thomas, Lalli, Enzo, and Bardoni, Barbara
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- 2024
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34. Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste
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Alfonso Trezza, Roberta Barletta, Michela Geminiani, Luisa Frusciante, Tommaso Olmastroni, Filomena Sannio, Jean-Denis Docquier, and Annalisa Santucci
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chestnut burrs ,circular bioeconomy ,antimicrobial activity ,Enterococcus faecalis ,molecular modeling ,docking simulations ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Currently, one-third of global food production, accounting for 1.3 billions tons, goes wasted due to major humanitarian and environmental challenges. In such a scenario, the circular bioeconomy model stands as an innovative solution by promoting sustainable production, utilizing agri-food waste, and converting non-renewable products into valuable resources. Here, the circular bioeconomy concept was applied on a previously obtained chestnut burr extract (agri-food waste) composed of gallic acid, quinic acid, protocatechuic acid, brevifolin carboxylic acid, and ellagic acid to evaluate its antimicrobial activity against four bacterial opportunistic pathogens (Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli). Our results evidenced a modest but measurable antibacterial activity against Enterococcus faecalis, with a minimum inhibitory concentration (MIC) of 64 μg/mL. In silico studies allowed for identifying the potential molecular target, supporting the underlying antibacterial activity of the active principle and providing useful molecular findings regarding their interaction. In this study, we show a robust and comprehensive in vitro and in silico pipeline aimed at the identification of novel antibacterial scaffolds taking advantage of agri-food waste.
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- 2024
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35. Alkaptonuria: From Molecular Insights to a Dedicated Digital Platform
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Maria Serena Milella, Michela Geminiani, Alfonso Trezza, Anna Visibelli, Daniela Braconi, and Annalisa Santucci
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amyloid ,artificial intelligence ,biomarkers ,cartilage ,inflammation ,machine learning ,Cytology ,QH573-671 - Abstract
Alkaptonuria (AKU) is a genetic disorder that affects connective tissues of several body compartments causing cartilage degeneration, tendon calcification, heart problems, and an invalidating, early-onset form of osteoarthritis. The molecular mechanisms underlying AKU involve homogentisic acid (HGA) accumulation in cells and tissues. HGA is highly reactive, able to modify several macromolecules, and activates different pathways, mostly involved in the onset and propagation of oxidative stress and inflammation, with consequences spreading from the microscopic to the macroscopic level leading to irreversible damage. Gaining a deeper understanding of AKU molecular mechanisms may provide novel possible therapeutical approaches to counteract disease progression. In this review, we first describe inflammation and oxidative stress in AKU and discuss similarities with other more common disorders. Then, we focus on HGA reactivity and AKU molecular mechanisms. We finally describe a multi-purpose digital platform, named ApreciseKUre, created to facilitate data collection, integration, and analysis of AKU-related data.
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- 2024
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36. Repurposing Castanea sativa Spiny Burr By-Products Extract as a Potentially Effective Anti-Inflammatory Agent for Novel Future Biotechnological Applications
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Luisa Frusciante, Michela Geminiani, Tommaso Olmastroni, Pierfrancesco Mastroeni, Alfonso Trezza, Laura Salvini, Stefania Lamponi, Ottavia Spiga, and Annalisa Santucci
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Castanea sativa ,waste repurposing ,polyphenols ,UPLC-MS/MS ,inflammation ,RAW 264.7 ,Science - Abstract
The concept of a “circular bioeconomy” holds great promise for the health, cosmetic, and nutrition sectors by re-using Castanea sativa (Mill.) by-products. This sustainable resource is rich in bioactive secondary metabolites with antioxidant and anti-inflammatory properties. By transforming these by-products into high-value products for human health, we can promote sustainable economic growth and reduce the environmental impact of traditional waste disposal, adding value to previously underutilized resources. In the present study, we investigated the antioxidant capacity, phytochemical composition, and in vitro antioxidant and anti-inflammatory activity of C. sativa burr (CSB) aqueous extract. The spectrophotometric study revealed high total phenolic content (TPC) values with significant antioxidant and anti-radical properties. Using UPLC-MS/MS techniques, the phytochemical investigation identified 56 metabolites, confirming the presence of phenolic compounds in CSBs. In addition, CSBs significantly downregulated pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophage cells without significant cell toxicity. Lastly, in silico studies pinpointed three kinases from RAW 264.7 cells as binding partners with ellagic acid, the predominant compound found in our extract. These findings strongly advocate for the recycling and valorization of C. sativa by-products, challenging their conventional classification as mere “waste”.
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- 2024
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37. Molecular and Evolution In Silico Studies Unlock the h4-HPPD C-Terminal Tail Gating Mechanism
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Alfonso Trezza, Ancuta Birgauan, Michela Geminiani, Anna Visibelli, and Annalisa Santucci
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4-HPPD ,gating ,mutagenesis ,C-terminal tail ,molecular modeling ,molecular dynamics simulations ,Biology (General) ,QH301-705.5 - Abstract
The enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) is involved in the catabolism of the amino acid tyrosine in organisms such as bacteria, plants, and animals. It catalyzes the conversion of 4-hydroxyphenylpyruvate to a homogenisate in the presence of molecular oxygen and Fe(II) as a cofactor. This enzyme represents a key step in the biosynthesis of important compounds, and its activity deficiency leads to severe, rare autosomal recessive disorders, like tyrosinemia type III and hawkinsinuria, for which no cure is currently available. The 4-HPPD C-terminal tail plays a crucial role in the enzyme catalysis/gating mechanism, ensuring the integrity of the active site for catalysis through fine regulation of the C-terminal tail conformation. However, despite growing interest in the 4-HPPD catalytic mechanism and structure, the gating mechanism remains unclear. Furthermore, the absence of the whole 3D structure makes the bioinformatic approach the only possible study to define the enzyme structure/molecular mechanism. Here, wild-type 4-HPPD and its mutants were deeply dissected by applying a comprehensive bioinformatics/evolution study, and we showed for the first time the entire molecular mechanism and regulation of the enzyme gating process, proposing the full-length 3D structure of human 4-HPPD and two novel key residues involved in the 4-HPPD C-terminal tail conformational change.
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- 2024
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38. Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract
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Luisa Frusciante, Michela Geminiani, Alfonso Trezza, Tommaso Olmastroni, Pierfrancesco Mastroeni, Laura Salvini, Stefania Lamponi, Andrea Bernini, Daniela Grasso, Elena Dreassi, Ottavia Spiga, and Annalisa Santucci
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Chaetomorpha linum ,macroalgae ,UPLC-MS/MS ,inflammation ,RAW 264.7 ,HaCaT ,Biology (General) ,QH301-705.5 - Abstract
Utilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest, and this study aimed to demonstrate promising outcomes from an extract obtained from an underutilized plant waste. Chaetomorpha linum, an invasive macroalga found in the Orbetello Lagoon, thrives in eutrophic conditions, forming persistent mats covering approximately 400 hectares since 2005. The biomass of C. linum undergoes mechanical harvesting and is treated as waste, requiring significant human efforts and economic resources—A critical concern for municipalities. Despite posing challenges to local ecosystems, the study identified C. linum as a natural source of bioactive metabolites. Phytochemical characterization revealed lipids, amino acids, and other compounds with potential anti-inflammatory activity in C. linum extract. In vitro assays with LPS-stimulated RAW 264.7 and TNF-α/IFN-γ-stimulated HaCaT cells showed the extract inhibited reactive oxygen species (ROS), nitric oxide (NO), and prostaglandin E2 (PGE2) productions, and reduced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions via NF-κB nuclear translocation, in RAW 264.7 cells. It also reduced chemokines (TARC/CCL17, RANTES/CCL5, MCP-1/CCL2, and IL-8) and the cytokine IL-1β production in HaCaT cells, suggesting potential as a therapeutic candidate for chronic diseases like atopic dermatitis. Finally, in silico studies indicated palmitic acid as a significant contributor to the observed effect. This research not only uncovered the untapped potential of C. linum but also laid the foundation for its integration into the circular bioeconomy, promoting sustainable practices, and innovative applications across various industries.
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- 2024
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39. Deterministic Multi-sensor Measurement-adaptive Birth using Labeled Random Finite Sets.
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Jennifer Bondarchuk, Anthony Trezza, and Donald J. Bucci
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- 2023
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40. On Gibbs Sampling Architecture for Labeled Random Finite Sets Multi-Object Tracking.
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Anthony Trezza, Donald J. Bucci Jr., and Pramod K. Varshney
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- 2023
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41. Early social isolation differentially affects the glucocorticoid receptor system and alcohol-seeking behavior in male and female Marchigian Sardinian alcohol-preferring rats
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Benvenuti, F., De Carlo, S., Rullo, L., Caffino, L., Losapio, L.M., Morosini, C., Ubaldi, M., Soverchia, L., Cannella, N., Domi, E., Candeletti, S., Mottarlini, F., Fattore, L., Romualdi, P., Fumagalli, F., Trezza, V., Roberto, M., and Ciccocioppo, R.
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- 2024
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42. Analysis of land cover dynamics in Mozambique (2001–2016)
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Cianciullo, Silvio, Attorre, Fabio, Trezza, Francesca Romana, Rezende, Marcelo, Ntumi, Cornelio, Campira, Joaquim, Munjovo, Edna Tânia, Timane, Renato David, Riccardi, Tullia, and Malatesta, Luca
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- 2023
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43. Early-stage cervical cancer treatment – what’s new?
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Camilla Di Dio, Ilham Azenkoud, Angelo Trezza, Emanuele Lentini, Tullio Golia D’Augè, Ilaria Cuccu, Giorgia Di Bartolomeo, Ilaria Firulli, Andrea Canicchio, Ludovica Sgamba, and Ludovico Muzii
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minimally invasive surgery ,gynaecological cancer ,laparoscopic approach ,cervical cancer ,hysterectomy. ,Medicine - Abstract
The gold standard of treatment for patients with early-stage cervical cancer is radical hysterectomy, in agreement with the entire scientific community. During the last decade, growing evidence has supported the minimally invasive approach. Several studies have suggested that the minimally invasive approach could improve surgical and perioperative outcomes. Because of these findings, ESCO/ESTRO/ESP guidelines state that a “minimally invasive approach is favoured” in comparison with open surgery, as a grade B recommendation. Because of the lack of a grade A recommendation, this randomized Laparoscopic Approach to Cervical Cancer trial evaluated open vs. minimally invasive approach in the early stage. It demonstrated an increase in mortality among patients treated with minimally invasive surgery, revolutionizing current thinking on the primary surgical approach to early cervical cancer. The aim of this study is to analyse which is the best treatment for early cervical cancer and which approach is the most effective at the moment. Further studies are needed to state with certainty the appropriateness of the treatments offered to patients with early cervical cancer.
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- 2023
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44. Early social isolation differentially affects the glucocorticoid receptor system and alcohol-seeking behavior in male and female Marchigian Sardinian alcohol-preferring rats
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F. Benvenuti, S. De Carlo, L. Rullo, L. Caffino, L.M. Losapio, C. Morosini, M. Ubaldi, L. Soverchia, N. Cannella, E. Domi, S. Candeletti, F. Mottarlini, L. Fattore, P. Romualdi, F. Fumagalli, V. Trezza, M. Roberto, and R. Ciccocioppo
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Alcoholism ,Reward ,Glucocorticoid receptor ,Alcohol drinking ,Stress ,Relapse ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Adverse early life experiences during postnatal development can evoke long-lasting neurobiological changes in stress systems, thereby affecting subsequent behaviors including propensity to develop alcohol use disorder. Here, we exposed genetically selected male and female Marchigian Sardinian alcohol-preferring (msP) and Wistar rats to mild, repeated social deprivation from postnatal day 14 (PND14) to PND21 and investigated the effect of the early social isolation (ESI) on the glucocorticoid receptor (GR) system and on the propensity to drink and seek alcohol in adulthood. We found that ESI resulted in higher levels of GR gene and protein expression in the prefrontal cortex (PFC) in male but not female msP rats. In female Wistars, ESI resulted in significant downregulation of Nr3c1 mRNA levels and lower GR protein levels. In male and female msP rats, plasma corticosterone levels on PND35 were similar and unaffected by ESI. Wistar females exhibited higher levels of corticosterone compared with males, independently from ESI. In alcohol self-administration experiments we found that the pharmacological stressor yohimbine (0.0, 0.312, 0.625, and 1.25 mg/kg) increased alcohol self-administration in both rat lines, regardless of ESI. After extinction, 0.625 mg/kg yohimbine significantly reinstated alcohol seeking in female rats only. ESI enhanced reinstatement in female msP rats. Overall, the present results indicate that repeated social deprivation during the third week of postnatal life affects GR expression in a strain- and sex-dependent manner: such effect may contribute, at least partially, to the heightened sensitivity of female msP rats to the effects of yohimbine-induced alcohol seeking.
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- 2024
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45. Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats
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Laura Rullo, Loredana Maria Losapio, Camilla Morosini, Francesca Mottarlini, Sara Schiavi, Valeria Buzzelli, Fabrizio Ascone, Roberto Ciccocioppo, Liana Fattore, Lucia Caffino, Fabio Fumagalli, Patrizia Romualdi, Viviana Trezza, and Sanzio Candeletti
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early social isolation ,endocannabinoids ,HPA axis ,adolescence ,communal nesting ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Social and emotional experiences differently shape individual’s neurodevelopment inducing substantial changes in neurobiological substrates and behavior, particularly when they occur early in life. In this scenario, the present study was aimed at (i) investigating the impact of early social environments on emotional reactivity of adolescent male and female rats and (ii) uncovering the underlying molecular features, focusing on the cortical endocannabinoid (eCB) and glucocorticoid systems. To this aim, we applied a protocol of environmental manipulation based on early postnatal socially enriched or impoverished conditions. Social enrichment was realized through communal nesting (CN). Conversely, an early social isolation (ESI) protocol was applied (post-natal days 14–21) to mimic an adverse early social environment. The two forms of social manipulation resulted in specific behavioral and molecular outcomes in both male and female rat offspring. Despite the combination of CN and ESI did not affect emotional reactivity in both sexes, the molecular results reveal that the preventive exposure to CN differently altered mRNA and protein expression of the main components of the glucocorticoid and eCB systems in male and female rats. In particular, adolescent females exposed to the combination of CN and ESI showed increased corticosterone levels, unaltered genomic glucocorticoid receptor, reduced cannabinoid receptor type-1 and fatty acid amide hydrolase protein levels, suggesting that the CN condition evokes different reorganization of these systems in males and females.
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- 2023
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46. Leveraging composition-based energy material descriptors for machine learning models
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Trezza, Giovanni and Chiavazzo, Eliodoro
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- 2023
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47. Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
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D’Antoni, Simona, Schiavi, Sara, Buzzelli, Valeria, Giuffrida, Samuele, Feo, Alessandro, Ascone, Fabrizio, Busceti, Carla Letizia, Nicoletti, Ferdinando, Trezza, Viviana, and Catania, Maria Vincenza
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- 2024
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48. Psilocybin mitigates the cognitive deficits observed in a rat model of Fragile X syndrome
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Buzzelli, Valeria, Carbone, Emilia, Manduca, Antonia, Schiavi, Sara, Feo, Alessandro, Perederiy, Julia V., Ambert, Kyle H., Hausman, Marvin, and Trezza, Viviana
- Published
- 2023
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49. A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass
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Alfonso Trezza, Michela Geminiani, Giuseppe Cutrera, Elena Dreassi, Luisa Frusciante, Stefania Lamponi, Ottavia Spiga, and Annalisa Santucci
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drug and target discovery ,molecular modeling ,docking and molecular dynamics simulation ,chestnut burr ,natural bioproduct ,bioeconomy ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Currently, many environmental and energy-related problems are threatening the future of our planet. In October 2022, the Worldmeter recorded the world population as 7.9 billion people, estimating that there will be an increase of 2 billion by 2057. The rapid growth of the population and the continuous increase in needs are causing worrying conditions, such as pollution, climate change, global warming, waste disposal, and natural resource reduction. Looking for novel and innovative methods to overcome these global troubles is a must for our common welfare. The circular bioeconomy represents a promising strategy to alleviate the current conditions using biomass-like natural wastes to replace commercial products that have a negative effect on our ecological footprint. Applying the circular bioeconomy concept, we propose an integrated in silico and in vitro approach to identify antioxidant bioactive compounds extracted from chestnut burrs (an agroforest waste) and their potential biological targets. Our study provides a novel and robust strategy developed within the circular bioeconomy concept aimed at target and drug discovery for a wide range of diseases. Our study could open new frontiers in the circular bioeconomy related to target and drug discovery, offering new ideas for sustainable scientific research aimed at identifying novel therapeutical strategies.
- Published
- 2024
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- View/download PDF
50. Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood
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Jessica Bratzu, Maria Ciscato, Augusta Pisanu, Giuseppe Talani, Roberto Frau, Patrizia Porcu, Marco Diana, Fabio Fumagalli, Patrizia Romualdi, Laura Rullo, Viviana Trezza, Roberto Ciccocioppo, Fabrizio Sanna, and Liana Fattore
- Subjects
early-life stress ,social enrichment ,isolation ,communal nesting ,anxiety-like behaviors ,marble-burying ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
IntroductionEarly social isolation (ESI) disrupts neurodevelopmental processes, potentially leading to long-lasting emotional and cognitive changes in adulthood. Communal nesting (CN), i.e., the sharing of parental responsibilities between multiple individuals in a nest, creates a socially enriching environment known to impact social and anxiety-related behaviors.MethodsThis study examines the effects of (i) the CN condition and of (ii) ESI during the 3rd week of life (i.e., pre-weaning ESI) on motor, cognitive, and emotional domains during adolescence and adulthood in male and female rats reared in the two different housing conditions, as well as (iii) the potential of CN to mitigate the impact of ESI on offspring.ResultsWe found that in a spontaneous locomotor activity test, females exhibited higher activity levels compared to males. In female groups, adolescents reared in standard housing (SH) condition spent less time in the center of the arena, suggestive of increased anxiety levels, while the CN condition increased the time spent in the center during adolescence, but not adulthood, independently from ESI. The prepulse inhibition (PPI) test showed a reduced PPI in ESI adolescent animals of both sexes and in adult males (but not in adult females), with CN restoring PPI in males, but not in adolescent females. Further, in the marble burying test SH-ESI adolescent males exhibited higher marble burying behavior than all other groups, suggestive of obsessive-compulsive traits. CN completely reversed this stress-induced effect. Interestingly, ESI and CN did not have a significant impact on burying behavior in adult animals of both sexes.DiscussionOverall, our findings (i) assess the effects of ESI on locomotion, sensorimotor gating, and compulsive-like behaviors, (ii) reveal distinct vulnerabilities of males and females within these domains, and (iii) show how early-life social enrichment may successfully counteract some of the behavioral alterations induced by early-life social stress in a sex-dependent manner. This study strengthens the notion that social experiences during early-life can shape emotional and cognitive outcomes in adulthood, and points to the importance of social enrichment interventions for mitigating the negative effects of early social stress on neurodevelopment.
- Published
- 2023
- Full Text
- View/download PDF
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