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1. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials

Author

Zi, Wenjie, Nogueira, Raul, Yang, Qingwu, Liu, Jianmin, Yang, Pengfei, Zhang, Yongwei, Yan, Bernard, Mitchell, Peter, Miao, Zhong Rong, Majoie, Charles B., Roos, Yvo B., Suzuki, Kentaro, Kimura, Kazumi, Matsumaru, Yuji, Fischer, Urs, Gralla, Jan, Cavalcante, Fabiano W., Kappelhof, Manon, Treurniet, Kilian M., Kaesmacher, Johannes, Zhang, Lei, Bush, Steven, Nieboer, Daan, Lingsma, Hester F., Rothwell, Peter, Saver, Jeffrey, Fiehler, Jens, Li, Fengli, Huang, Jiacheng, Song, Jiaxing, Hong, Bo, Chen, Wenhuo, Peng, Ya, Han, Hongxing, Zhang, Liyong, Li, Zifu, Xing, Pengfei, Shen, Hongjian, Zhang, Ping, Zhang, Xiaoxi, Davis, Stephen, Nguyen, Huy-Thang, Donnan, Geoffrey, Huo, Xiaochuan, Nan, Guangxian, Bivard, Andrew, Ma, Henry, Vu, Dang Lu, Campbell, Bruce, Rinkel, Leon A., Emmer, Bart J., Coutinho, Jonathan M., LeCouffe, Natalie E., Dippel, Diederik W., van der Lugt, Aad, van Zwam, Wim H., van Oostenbrugge, Robert J., Uyttenboogaart, Maarten, Costalat, Vincent, Lycklama, Geert, Hofmeijer, Jeannette, van Norden, Anouk, Otsuka, Toshiaki, Takeuchi, Masataka, Morimoto, Masafumi, Kanazawa, Ryuzaburo, Takayama, Yohei, Kamiya, Yuki, Shigeta, Keigo, Okubo, Seiji, Hayakawa, Mikito, Strbian, Daniel, Eker, Omer, Cognard, Christophe, Meinel, Thomas, Dobrocky, Tomas, Jung, Simon, Piechowiak, Eike, Marnat, Gaultier, Sibon, Igor, Bourcier, Romain, de Gaalon, Solene, Papagiannaki, Chrysanthi, Lefebvre, Margaux, Majoie, Charles B, Cavalcante, Fabiano, Treurniet, Kilian M, Miao, Zhongrong, Rinkel, Leon A, Wang, Shouchun, Coutinho, Jonathan M, Emmer, Bart J, LeCouffe, Natalie E, Lingsma, Hester F, Nogueira, Raul G, and Roos, Yvo B

Published
2023
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2. Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study

Author

Knapen, Robrecht R.M.M., Pirson, F. Anne V., Langezaal, Lucianne C.M., Brouwer, Josje, Majoie, Charles B.L.M., Emmer, Bart J., Vos, Jan-Albert, van Doormaal, Pieter-Jan, Yoo, Albert J., Bruggeman, Agnetha A.E., Lycklama à Nijeholt, Geert J., van der Leij, Chirstiaan, van Oostenbrugge, Robert J., van Zwam, Wim H., Schonewille, Wouter J., Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert-Jan B., Compagne, Kars C.J., Kappelhof, Manon, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van der Lugt, Aad, Roos, Yvo B.W.E.M., Wermer, Marieke J.H., van Walderveen, Marianne A.A., van Es, Adriaan C.G.M., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Boiten, Jelis, de Bruijn, Sebastiaan F., van Dijk, Lukas C., Bart van der Worp, H., Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Beenen, Ludo F.M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Bot, Joost, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Menno Krietemeijer, G., Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Cornelissen, Sandra, Brans, Rutger, Dippel, Diederik W.J., van der Lugt, Aad, Roos, Yvo B.W.E.M., Boiten, Jelis, Hofmeijer, Jeannette, Martens, Jasper M., Bart van der Worp, H., Lo, Rob H., Hofmeijer, Jeannette, Zwenneke Flach, H., Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E.D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., and Boodt, Nikki

Published
2024
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3. Association between computed tomography perfusion and the effect of intravenous alteplase prior to endovascular treatment in acute ischemic stroke

Author

Hoving, Jan W., van Voorst, Henk, Peerlings, Daan, Daems, Jasper D., Koopman, Miou S., Wouters, Anke, Kappelhof, Manon, LeCouffe, Natalie E., Treurniet, Kilian M., Bruggeman, Agnetha A. E., Rinkel, Leon A., van den Wijngaard, Ido R., Coutinho, Jonathan M., van der Lugt, Aad, Marquering, Henk A., Roos, Yvo B. W. E. M., Majoie, Charles B. L. M., and Emmer, Bart J.

Published
2023
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4. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice

Author

van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., van Zwam, Wim H., van der Lugt, Aad, van der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert- Jan B., Compagne, Kars C.J., Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Dippel, Diederik W.J., Roozenbeek, Bob, van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Vos, Jan Albert, Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Martens, Jasper M., Lycklama à Nijeholt, Geert J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L.M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Lycklama à Nijeholt, Geert J., van Walderveen, Marianne A.A., Sprengers, Marieke E.S., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Martens, Jasper M., Yo, Lonneke S.F., Vos, Jan Albert, Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, Bokkers, Reinoud P.H., van Proosdij, Marc P., Krietemeijer, G. Menno, Peluso, Jo P., Boogaarts, Hieronymus D., Lo, Rob, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Dippel, Diederik W.J., van Oostenbrugge, Robert J., Lycklama à Nijeholt, Geert J., Vos, Jan Albert, Schonewille, Wouter J., Hofmeijer, Jeannette, Martens, Jasper M., van der Worp, H. Bart, Lo, Rob H., van Oostenbrugge, Robert J., Hofmeijer, Jeannette, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., LeCouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.

Published
2023
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6. Cross‐Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy

Author

Kaesmacher, Johannes, primary, Treurniet, Kilian M., additional, Kappelhof, Manon, additional, Dobrocky, Tomas, additional, Ospel, Johanna, additional, Mujanovic, Adnan, additional, Fiehler, Jens, additional, Yan, Bernard, additional, Goyal, Mayank, additional, Yoo, Albert J., additional, Campbell, Bruce, additional, Zaidat, Osama O., additional, Saver, Jeffrey L., additional, Sanossian, Nerses, additional, Raychev, Radoslav, additional, Roos, Yvo B. W. E. M., additional, Fischer, Urs, additional, Majoie, Charles B. L. M., additional, Gralla, Jan, additional, and Liebeskind, David S., additional

Published
2024
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7. Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis

Author

Kaesmacher, Johannes, Cavalcante, Fabiano, Kappelhof, Manon, Treurniet, Kilian M, Rinkel, Leon, Liu, Jianmin, Yan, Bernard, Zi, Wenjie, Kimura, Kazumi, Eker, Omer F, Zhang, Yongwei, Piechowiak, Eike I, van Zwam, Wim, Liu, Sheng, Strbian, Daniel, Uyttenboogaart, Maarten, Dobrocky, Tomas, Miao, Zhongrong, Suzuki, Kentaro, Zhang, Lei, van Oostenbrugge, Robert, Meinel, Thomas R, Guo, Changwei, Seiffge, David, Yin, Congguo, Bütikofer, Lukas, Lingsma, Hester, Nieboer, Daan, Yang, Pengfei, Mitchell, Peter, Majoie, Charles, Fischer, Urs, Roos, Yvo, Gralla, Jan, IRIS Collaborators, Kaesmacher, Johannes, Cavalcante, Fabiano, Kappelhof, Manon, Treurniet, Kilian M, Rinkel, Leon, Liu, Jianmin, Yan, Bernard, Zi, Wenjie, Kimura, Kazumi, Eker, Omer F, Zhang, Yongwei, Piechowiak, Eike I, van Zwam, Wim, Liu, Sheng, Strbian, Daniel, Uyttenboogaart, Maarten, Dobrocky, Tomas, Miao, Zhongrong, Suzuki, Kentaro, Zhang, Lei, van Oostenbrugge, Robert, Meinel, Thomas R, Guo, Changwei, Seiffge, David, Yin, Congguo, Bütikofer, Lukas, Lingsma, Hester, Nieboer, Daan, Yang, Pengfei, Mitchell, Peter, Majoie, Charles, Fischer, Urs, Roos, Yvo, Gralla, Jan, and IRIS Collaborators

Abstract

IMPORTANCE: The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke declines with longer time from symptom onset, but it is not known whether a similar time dependency exists for IVT followed by thrombectomy. OBJECTIVE: To determine whether the benefit associated with IVT plus thrombectomy vs thrombectomy alone decreases with treatment time from symptom onset. DESIGN, SETTING, AND PARTICIPANTS: Individual participant data meta-analysis from 6 randomized clinical trials comparing IVT plus thrombectomy vs thrombectomy alone. Enrollment was between January 2017 and July 2021 at 190 sites in 15 countries. All participants were eligible for IVT and thrombectomy and presented directly at thrombectomy-capable stroke centers (n?=?2334). For this meta-analysis, only patients with an anterior circulation large-vessel occlusion were included (n?=?2313). EXPOSURE: Interval from stroke symptom onset to expected administration of IVT and treatment with IVT plus thrombectomy vs thrombectomy alone. MAIN OUTCOMES AND MEASURES: The primary outcome analysis tested whether the association between the allocated treatment (IVT plus thrombectomy vs thrombectomy alone) and disability at 90 days (7-level modified Rankin Scale [mRS] score range, 0 [no symptoms] to 6 [death]; minimal clinically important difference for the rates of mRS scores of 0-2: 1.3%) varied with times from symptom onset to expected administration of IVT. RESULTS: In 2313 participants (1160 in IVT plus thrombectomy group vs 1153 in thrombectomy alone group; median age, 71 [IQR, 62 to 78] years; 44.3% were female), the median time from symptom onset to expected administration of IVT was 2 hours 28 minutes (IQR, 1 hour 46 minutes to 3 hours 17 minutes). There was a statistically significant interaction between the time from symptom onset to expected administration of IVT and the association of allocated treatment with functional outcomes (ratio of adjusted common odds ratio [OR] per 1-hour delay, 0.84 [95%

Published
2024

8. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials

Author

Majoie, Charles B, primary, Cavalcante, Fabiano, additional, Gralla, Jan, additional, Yang, Pengfei, additional, Kaesmacher, Johannes, additional, Treurniet, Kilian M, additional, Kappelhof, Manon, additional, Yan, Bernard, additional, Suzuki, Kentaro, additional, Zhang, Yongwei, additional, Li, Fengli, additional, Morimoto, Masafumi, additional, Zhang, Lei, additional, Miao, Zhongrong, additional, Rinkel, Leon A, additional, Huang, Jiacheng, additional, Otsuka, Toshiaki, additional, Wang, Shouchun, additional, Davis, Stephen, additional, Cognard, Christophe, additional, Hong, Bo, additional, Coutinho, Jonathan M, additional, Song, Jiaxing, additional, Chen, Wenhuo, additional, Emmer, Bart J, additional, Eker, Omer, additional, Zhang, Liyong, additional, Dobrocky, Tomas, additional, Nguyen, Huy-Thang, additional, Bush, Steven, additional, Peng, Ya, additional, LeCouffe, Natalie E, additional, Takeuchi, Masataka, additional, Han, Hongxing, additional, Matsumaru, Yuji, additional, Strbian, Daniel, additional, Lingsma, Hester F, additional, Nieboer, Daan, additional, Yang, Qingwu, additional, Meinel, Thomas, additional, Mitchell, Peter, additional, Kimura, Kazumi, additional, Zi, Wenjie, additional, Nogueira, Raul G, additional, Liu, Jianmin, additional, Roos, Yvo B, additional, Fischer, Urs, additional, Nogueira, Raul, additional, Miao, Zhong Rong, additional, Majoie, Charles B., additional, Roos, Yvo B., additional, Cavalcante, Fabiano W., additional, Treurniet, Kilian M., additional, Lingsma, Hester F., additional, Rothwell, Peter, additional, Saver, Jeffrey, additional, Fiehler, Jens, additional, Li, Zifu, additional, Xing, Pengfei, additional, Shen, Hongjian, additional, Zhang, Ping, additional, Zhang, Xiaoxi, additional, Donnan, Geoffrey, additional, Huo, Xiaochuan, additional, Nan, Guangxian, additional, Bivard, Andrew, additional, Ma, Henry, additional, Vu, Dang Lu, additional, Campbell, Bruce, additional, Rinkel, Leon A., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, LeCouffe, Natalie E., additional, Dippel, Diederik W., additional, van der Lugt, Aad, additional, van Zwam, Wim H., additional, van Oostenbrugge, Robert J., additional, Uyttenboogaart, Maarten, additional, Costalat, Vincent, additional, Lycklama, Geert, additional, Hofmeijer, Jeannette, additional, van Norden, Anouk, additional, Kanazawa, Ryuzaburo, additional, Takayama, Yohei, additional, Kamiya, Yuki, additional, Shigeta, Keigo, additional, Okubo, Seiji, additional, Hayakawa, Mikito, additional, Jung, Simon, additional, Piechowiak, Eike, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Bourcier, Romain, additional, de Gaalon, Solene, additional, Papagiannaki, Chrysanthi, additional, and Lefebvre, Margaux, additional

Published
2023
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10. Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank

Author

Hund, Hajo M., Boodt, Nikki, Hansen, Daniel, Haffmans, Willem A., Lycklama à Nijeholt, Geert J., Hofmeijer, Jeannette, Dippel, Diederik W. J., van der Lugt, Aad, van Es, Adriaan C. G. M., van Beusekom, Heleen M. M., Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., van Oostenbrugge, Robert J., van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G. H., Mulder, Maxim J. H. L., Goldhoorn, Robert- Jan B., Compagne, Kars C. J., Kappelhof, Manon, Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Emmer, Bart J., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Martens, Jasper M., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Vries, J., de Kort, Paul L. M., van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P. H., Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Yo, Lonneke S. F., den Hertog, Heleen M., Bulut, Tomas, Brouwers, Paul J. A. M., Sprengers, Marieke E. S., Jenniskens, Sjoerd F. M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F. M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F. W., van den Wijngaard, Ido R., Bot, Joost, van Doormaal, Pieter-Jan, Meijer, Anton, Ghariq, Elyas, van Proosdij, Marc P., Krietemeijer, G. Menno, Dinkelaar, Wouter, Appelman, Auke P. A., Hammer, Bas, Pegge, Sjoert, van der Hoorn, Anouk, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R. M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M. M., Huguet, J., Groot, P. F. C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J. H. F., Schupp, Lieve M., Collette, Sabine L., Groot, Adrien E. D., LeCouffe, Natalie E., Konduri, Praneeta R., Prasetya, Haryadi, Arrarte-Terreros, Nerea, Ramos, Lucas A., Radiology and Nuclear Medicine, ACS - Microcirculation, ANS - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, ANS - Cellular & Molecular Mechanisms, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Biomedical Engineering and Physics, AMS - Amsterdam Movement Sciences, ANS - Brain Imaging, Adult Psychiatry, APH - Methodology, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Cardiology, Radiology & Nuclear Medicine, Radiology and nuclear medicine, Internal medicine, Pediatrics, Amsterdam Neuroscience - Neurovascular Disorders, and CCA - Imaging and biomarkers

Subjects
Microscopy, Ischemic stroke, Radiology, Nuclear Medicine and imaging, Endovascular treatment, Neurology (clinical), Cardiology and Cardiovascular Medicine, Mechanical thrombectomy, Stent-retriever, Thrombus
Abstract

Purpose The composition of thrombi retrieved during endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) may differ depending on their origin. In this study, we investigated the association between thrombus composition and stroke etiology in a large population of patients from the Dutch MR CLEAN Registry treated with EVT in daily clinical practice. Methods The thrombi of 332 patients with AIS were histologically analyzed for red blood cells (RBC), fibrin/platelets (F/P), and white blood cells (leukocytes) using a machine learning algorithm. Stroke etiology was assessed using the Trial of Org 10,172 in acute stroke treatment (TOAST) classification. Results The thrombi of cardioembolic origin contained less RBC and more F/P than those of non-cardioembolic origin (25.8% vs 41.2% RBC [p = 0.003] and 67.1% vs 54.5% F/P [p = 0.004]). The likelihood of a non-cardioembolic source of stroke increased with increasing thrombus RBC content (OR 1.02; [95% CI 1.00–1.06] for each percent increase) and decreased with a higher F/P content (OR 1.02; [95% CI 1.00–1.06]). Thrombus composition in patients with a cardioembolic origin and undetermined origin was similar. Conclusion Thrombus composition is significantly associated with stroke etiology, with an increase in RBC and a decrease in F/P raising the odds for a non-cardioembolic cause. No difference between composition of cardioembolic thrombi and of undetermined origin was seen. This emphasizes the need for more extensive monitoring for arrhythmias and/or extended cardiac analysis in case of an undetermined origin.

Published
2023
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11. Blood Pressure During Endovascular Treatment Under Conscious Sedation or Local Anesthesia

Author

Samuels, Noor, van de Graaf, Rob A., van den Berg, Carlijn A.L., Nieboer, Daan, Eralp, Ismail, Treurniet, Kilian M., Emmer, Bart J., Immink, Rogier V., Majoie, Charles B.L.M., van Zwam, Wim H., Bokkers, Reinoud P.H., Uyttenboogaart, Maarten, van Hasselt, Boudewijn A.A.M., Mühling, Jörg, Burke, James F., Roozenbeek, Bob, van der Lugt, Aad, Dippel, Diederik W.J., Lingsma, Hester F., and van Es, Adriaan C.G.M.

Published
2021
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15. Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion

Author

Guglielmi, Valeria, LeCouffe, Natalie E., Zinkstok, Sanne M., Compagne, Kars C.J., Eker, Reyhan, Treurniet, Kilian M., Tolhuisen, Manon. L., van der Worp, H. Bart, Jansen, Ivo G.H., van Oostenbrugge, Robert J., Marquering, Henk A., Dippel, Diederik W.J., Emmer, Bart J., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., and Coutinho, Jonathan M.

Published
2019
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17. Admission blood pressure and clinical outcomes in patients with acute ischaemic stroke treated with intravenous alteplase and endovascular treatment versus endovascular treatment alone: A MR CLEAN-NO IV substudy

Author

van den Berg, Sophie A, primary, Uniken Venema, Simone M, additional, LeCouffe, Natalie E, additional, Postma, Alida A, additional, Lycklama à Nijeholt, Geert J, additional, Rinkel, Leon A, additional, Treurniet, Kilian M, additional, Kappelhof, Manon, additional, Bruggeman, Agnetha E, additional, van Kranendonk, Katinka R, additional, Majoie, Charles BLM, additional, Dippel, Diederik WJ, additional, van der Worp, H Bart, additional, Coutinho, Jonathan M, additional, Nederkoorn, Paul J, additional, and Roos, Yvo BWEM, additional

Published
2023
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18. Validity of Early Outcomes as Indicators for Comparing Hospitals on Quality of Stroke Care

Author

Amini, Marzyeh, primary, Eijkenaar, Frank, additional, Lingsma, Hester F., additional, den Hartog, Sanne J., additional, Olthuis, Susanne G. H., additional, Martens, Jasper, additional, van der Worp, Bart, additional, van Zwam, Wim, additional, van der Hoorn, Anouk, additional, Roosendaal, Stefan D., additional, Roozenbeek, Bob, additional, Dippel, Diederik, additional, van Leeuwen, Nikki, additional, Dippel, Diederik W. J., additional, van der Lugt, Aad, additional, Majoie, Charles B. L. M., additional, Roos, Yvo B. W. E. M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Brouwer, Josje, additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Compagne, Kars C. J., additional, Goldhoorn, Robert‐Jan B., additional, Mulder, Maxim J. H. L., additional, Jansen, Ivo G. H., additional, van Es, Adriaan C. G. M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L. M., additional, van Tuijl, Julia, additional, Peluso, Jo Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P. H., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, Yo, Lonneke S. F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Brouwers, Paul, additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Postma, Alida A., additional, van der Kallen, Bas F. W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter‐Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Peluso, Jo P., additional, Lo, Rob, additional, Dinkelaar, Wouter, additional, Appelman, Auke P. A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Huguet, J., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L. F., additional, Voogd, Eva J. H. F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E. D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte‐Terreros, Nerea, additional, and Ramos, Lucas A., additional

Published
2023
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19. Hemorrhage rates in patients with acute ischemic stroke treated with intravenous alteplase and thrombectomy versus thrombectomy alone

Author

van Kranendonk, Katinka R, Kappelhof, Manon, Bruggeman, Agnetha A E, Rinkel, Leon A, Treurniet, Kilian M, LeCouffe, Natalie, Emmer, Bart J, Coutinho, Jonathan M, Wolff, Lennard, van Zwam, Wim H, van Oostenbrugge, Robert J, van der Lugt, Aad, Dippel, Diederik W J, Roos, Yvo B W E M, Marquering, Henk A, Majoie, Charles B L M, MR CLEAN-NO IV Investigators, van Kranendonk, Katinka R, Kappelhof, Manon, Bruggeman, Agnetha A E, Rinkel, Leon A, Treurniet, Kilian M, LeCouffe, Natalie, Emmer, Bart J, Coutinho, Jonathan M, Wolff, Lennard, van Zwam, Wim H, van Oostenbrugge, Robert J, van der Lugt, Aad, Dippel, Diederik W J, Roos, Yvo B W E M, Marquering, Henk A, Majoie, Charles B L M, and MR CLEAN-NO IV Investigators

Abstract

BACKGROUND: Intravenous alteplase treatment (IVT) for acute ischemic stroke carries a risk of intracranial hemorrhage (ICH). However, reperfusion of an occluded vessel itself may contribute to the risk of ICH. We determined whether IVT and reperfusion are associated with ICH or its volume in the Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands (MR CLEAN)-NO IV trial.METHODS: The MR CLEAN-NO IV trial randomized patients with acute ischemic stroke due to large vessel occlusion to receive either IVT followed by endovascular treatment (EVT) or EVT alone. ICH was classified according to the Heidelberg bleeding classification on follow-up MRI or CT approximately 8 hours-7 days after stroke. Hemorrhage volume was measured with ITK-snap. Successful reperfusion was defined as extended Thrombolysis In Cerebral Infarction (eTICI) score of 2b-3. Multinomial and binary adjusted logistic regression were used to determine the association of IVT and reperfusion with ICH subtypes.RESULTS: Of 539 included patients, 173 (32%) developed ICH and 30 suffered from symptomatic ICH (sICH) (6%). Of the patients with ICH, 102 had hemorrhagic infarction, 47 had parenchymal hematoma, 44 had SAH, and six had other ICH. Reperfusion was associated with a decreased risk of SAH, and IVT was not associated with SAH (eTICI 2b-3: adjusted OR 0.45, 95% CI 0.21 to 0.97; EVT without IVT: OR 1.6, 95% CI 0.91 to 2.8). Reperfusion status and IVT were not associated with overall ICH, hemorrhage volume, and sICH (sICH: EVT without IVT, OR 0.96, 95% CI 0.41 to 2.25; eTICI 2b-3, OR 0.49, 95% CI 0.23 to 1.05).CONCLUSION: Neither IVT administration before EVT nor successful reperfusion after EVT were associated with ICH, hemorrhage volume, and sICH. SAH occurred more often in patients for whom successful reperfusion was not achieved.

Published
2023

20. Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice

Author

Neurologen, Brain, Circulatory Health, Stroke, MS Radiologie, Van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., Van Zwam, Wim H., Van Der Lugt, Aad, Van Der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Brouwer, Josje, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Lycklama À Nijeholt, Geert J., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., Den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Sprengers, Marieke E.S., Van Den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., Van Der Kallen, Bas F.W., Van Den Wijngaard, Ido R., Bot, Joost, Van Doormaal, Pieter Jan, Meijer, Anton, Ghariq, Elyas, Van Proosdij, Marc P., Krietemeijer, G. Menno, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., El Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, De Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, Van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., Van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, De Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P. F.C., Mens, Marieke A., Van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., Lecouffe, Natalie E., Prasetya, Haryadi, Ramos, Lucas A., Neurologen, Brain, Circulatory Health, Stroke, MS Radiologie, Van Voorst, Henk, Bruggeman, Agnetha A.E., Andriessen, Jurr, Hoving, Jan W., Konduri, Praneeta R., Yang, Wenjin, Kappelhof, Manon, Arrarte Terreros, Nerea, Roos, Yvo B.W.E.M., Van Zwam, Wim H., Van Der Lugt, Aad, Van Der Hoorn, Anouk, Boiten, Jelis, Roosendaal, Stefan, Jenniskens, Sjoerd, Caan, Matthan W.A., Marquering, Henk A., Emmer, Bart J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Van Oostenbrugge, Robert J., Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert Jan B., Compagne, Kars C.J., Brouwer, Josje, Den Hartog, Sanne J., Hinsenveld, Wouter H., Roozenbeek, Bob, Van Es, Adriaan C.G.M., Coutinho, Jonathan M., Schonewille, Wouter J., Wermer, Marieke J.H., Van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Lycklama À Nijeholt, Geert J., De Bruijn, Sebastiaan F., Van Dijk, Lukas C., Van Der Worp, H. Bart, Lo, Rob H., Van Dijk, Ewoud J., Boogaarts, Hieronymus D., De Vries, J., De Kort, Paul L.M., Van Tuijl, Julia, Peluso, Jo P., Fransen, Puck, Van Den Berg, Jan S.P., Van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eschgi, Omid, Bokkers, Reinoud P.H., Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., Den Hertog, Heleen M., Sturm, Emiel J.C., Brouwers, Paul J.A.M., Sprengers, Marieke E.S., Van Den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., Van Der Kallen, Bas F.W., Van Den Wijngaard, Ido R., Bot, Joost, Van Doormaal, Pieter Jan, Meijer, Anton, Ghariq, Elyas, Van Proosdij, Marc P., Krietemeijer, G. Menno, Gerrits, Dick, Dinkelaar, Wouter, Appelman, Auke P.A., Hammer, Bas, Pegge, Sjoert, Vinke, Saman, Flach, H. Zwenneke, Lingsma, Hester F., El Ghannouti, Naziha, Sterrenberg, Martin, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, Simons, Michelle, Vossers, Marjolein, De Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, Van Vemde, Gina, Simons, Tiny, Messchendorp, Gert, Nicolaij, Nynke, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Verheesen, Sabrina, Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Sandiman, Michelle, Aaldering, Nicoline, Zweedijk, Berber, Vervoort, Jocova, Ponjee, Eva, Romviel, Sharon, Kanselaar, Karin, Barning, Denn, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., Van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, De Jong, Anouk, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P. F.C., Mens, Marieke A., Van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuisen, Manon L., Alves, Heitor, Weterings, Annick J., Kirkels, Eleonora L.F., Voogd, Eva J.H.F., Schupp, Lieve M., Collette, Sabine, Groot, Adrien E.D., Lecouffe, Natalie E., Prasetya, Haryadi, and Ramos, Lucas A.

Published
2023

21. Thrombus Migration Paradox in Patients With Acute Ischemic Stroke

Author

Alves, Heitor C., Treurniet, Kilian M., Jansen, Ivo G.H., Yoo, Albert J., Dutra, Bruna G., Zhang, Guang, Yo, Lonneke, van Es, Adriaan C.G.M., Emmer, Bart J., van den Berg, René, van den Wijngaard, Ido R., Lycklama à Nijeholt, Geert J., Vos, Jan-Albert, Roos, Yvo B.W.E.M., Schonewille, Wouter, Marquering, Henk A., and Majoie, Charles B.L.M.

Published
2019
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22. Workflow Intervals of Endovascular Acute Stroke Therapy During On- Versus Off-Hours: The MR CLEAN Registry

Author

Hinsenveld, Wouter H., de Ridder, Inger R., van Oostenbrugge, Robert J., Vos, Jan A., Groot, Adrien E., Coutinho, Jonathan M., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Schonewille, Wouter J., Dippel, Diederik W.J., van der Lugt, Aad, Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., van Zwam, Wim H., Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert-Jan B., Compagne, Kars C.J., Kappelhof, Manon, Majoie, Charles B.L.M., Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, van Zwam, Wim H., Hofmeijer, Jeannette, Martens, Jasper M., Roozenbeek, Bob, Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Kort, Paul L.M., Peluso, Jo J.P., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Majoie, Charles B.L.M., van Zwam, Wim H., van der Lugt, Aad, van Walderveen, Marianne A.A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Emmer, Bart J., Martens, Jasper M., Yo, Lonneke S.F., Bot, Joost, van Doormaal, Pieter-Jan, Dippel, Diederik W.J., van der Lugt, Aad, Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., van Zwam, Wim H., Hofmeijer, Jeannette, Martens, Jasper M., van der Worp, H. Bart, Lo, Rob H., Hofmeijer, Jeannette, Flach, H. Zwenneke, Lingsma, Hester F., el Ghannouti, Naziha, Sterrenberg, Martin, Puppels, Corina, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, van Rijswijk, Cathelijn, Messchendorp, Gert, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, M., Jeurrissen, D., Bos, Ernas, Drabbe, Yvonne, Aaldering, Nicoline, Zweedijk, Berber, Khalilzada, Mostafa, Venema, Esmee, Chalos, Vicky, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Boersc, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Tolhuijsen, Manon L., and Alves, Heitor

Published
2019
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23. Thrombus Imaging Characteristics and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment

Author

Dutra, Bruna G., Tolhuisen, Manon L., Alves, Heitor C.B.R., Treurniet, Kilian M., Kappelhof, Manon, Yoo, Albert J., Jansen, Ivo G.H., Dippel, Diederik W.J., van Zwam, Wim H., van Oostenbrugge, Robert J., da Rocha, Antônio J., Lingsma, Hester F., van der Lugt, Aad, Roos, Yvo B.W.E.M., Marquering, Henk A., and Majoie, Charles B.L.M.

Published
2019
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25. Hemorrhage rates in patients with acute ischemic stroke treated with intravenous alteplase and thrombectomy versus thrombectomy alone.

Author

van Kranendonk, Katinka R., Kappelhof, Manon, Bruggeman, Agnetha A. E., Rinkel, Leon A., Treurniet, Kilian M., LeCouffe, Natalie, Emmer, Bart J., Coutinho, Jonathan M., Wolff, Lennard, van Zwam, Wim H., van Oostenbrugge, Robert J., van der Lugt, Aad, Dippel, Diederik W. J., Roos, Yvo B. W. E. M., Marquering, Henk A., and Majoie, Charles B. L. M.

Subjects
INTRAVENOUS therapy, CONFIDENCE intervals, ISCHEMIC stroke, INTRACRANIAL hemorrhage, THROMBECTOMY, DESCRIPTIVE statistics, RESEARCH funding, LOGISTIC regression analysis, ODDS ratio, TISSUE plasminogen activator, REPERFUSION injury, SECONDARY analysis
Abstract

Background Intravenous alteplase treatment (IVT) for acute ischemic stroke carries a risk of intracranial hemorrhage (ICH). However, reperfusion of an occluded vessel itself may contribute to the risk of ICH. We determined whether IVT and reperfusion are associated with ICH or its volume in the Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands (MR CLEAN)- NO IV trial. Methods The MR CLEAN NO IV trial randomized patients with acute ischemic stroke due to large vessel occlusion to receive either IVT followed by endovascular treatment (EVT) or EVT alone. ICH was classified according to the Heidelberg bleeding classification on follow-up MRI or CT approximately 8 hours-7 days after stroke. Hemorrhage volume was measured with ITK-snap. Successful reperfusion was defined as extended Thrombolysis In Cerebral Infarction (eTICI) score of 2b-3. Multinomial and binary adjusted logistic regression were used to determine the association of IVT and reperfusion with ICH subtypes. Results Of 539 included patients, 173 (32%) developed ICH and 30 suffered from symptomatic ICH (sICH) (6%). Of the patients with ICH, 102 had hemorrhagic infarction, 47 had parenchymal hematoma, 44 had SAH, and six had other ICH. Reperfusion was associated with a decreased risk of SAH, and IVT was not associated with SAH (eTICI 2b-3: adjusted OR 0.45, 95% CI 0.21 to 0.97; EVT without IVT: OR 1.6, 95% CI 0.91 to 2.8). Reperfusion status and IVT were not associated with overall ICH, hemorrhage volume, and sICH (sICH: EVT without IVT, OR 0.96, 95% CI 0.41 to 2.25; eTICI 2b-3, OR 0.49, 95% CI 0.23 to 1.05). Conclusion Neither IVT administration before EVT nor successful reperfusion after EVT were associated with ICH, hemorrhage volume, and sICH. SAH occurred more often in patients for whom successful reperfusion was not achieved. [ABSTRACT FROM AUTHOR]

Published
2023
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26. sj-docx-2-eso-10.1177_23969873231173274 – Supplemental material for Admission blood pressure and clinical outcomes in patients with acute ischaemic stroke treated with intravenous alteplase and endovascular treatment versus endovascular treatment alone: A MR CLEAN-NO IV substudy

Author

van den Berg, Sophie A, Uniken Venema, Simone M, LeCouffe, Natalie E, Postma, Alida A, Lycklama à Nijeholt, Geert J, Rinkel, Leon A, Treurniet, Kilian M, Kappelhof, Manon, Bruggeman, Agnetha E, van Kranendonk, Katinka R, Majoie, Charles BLM, Dippel, Diederik WJ, van der Worp, H Bart, Coutinho, Jonathan M, Nederkoorn, Paul J, and Roos, Yvo BWEM

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-2-eso-10.1177_23969873231173274 for Admission blood pressure and clinical outcomes in patients with acute ischaemic stroke treated with intravenous alteplase and endovascular treatment versus endovascular treatment alone: A MR CLEAN-NO IV substudy by Sophie A van den Berg, Simone M Uniken Venema, Natalie E LeCouffe, Alida A Postma, Geert J Lycklama à Nijeholt, Leon A Rinkel, Kilian M Treurniet, Manon Kappelhof, Agnetha E Bruggeman, Katinka R van Kranendonk, Charles BLM Majoie, Diederik WJ Dippel, H Bart van der Worp, Jonathan M Coutinho, Paul J Nederkoorn and Yvo BWEM Roos in European Stroke Journal

Published
2023
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27. sj-docx-1-eso-10.1177_23969873231173274 – Supplemental material for Admission blood pressure and clinical outcomes in patients with acute ischaemic stroke treated with intravenous alteplase and endovascular treatment versus endovascular treatment alone: A MR CLEAN-NO IV substudy

Author

van den Berg, Sophie A, Uniken Venema, Simone M, LeCouffe, Natalie E, Postma, Alida A, Lycklama à Nijeholt, Geert J, Rinkel, Leon A, Treurniet, Kilian M, Kappelhof, Manon, Bruggeman, Agnetha E, van Kranendonk, Katinka R, Majoie, Charles BLM, Dippel, Diederik WJ, van der Worp, H Bart, Coutinho, Jonathan M, Nederkoorn, Paul J, and Roos, Yvo BWEM

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231173274 for Admission blood pressure and clinical outcomes in patients with acute ischaemic stroke treated with intravenous alteplase and endovascular treatment versus endovascular treatment alone: A MR CLEAN-NO IV substudy by Sophie A van den Berg, Simone M Uniken Venema, Natalie E LeCouffe, Alida A Postma, Geert J Lycklama à Nijeholt, Leon A Rinkel, Kilian M Treurniet, Manon Kappelhof, Agnetha E Bruggeman, Katinka R van Kranendonk, Charles BLM Majoie, Diederik WJ Dippel, H Bart van der Worp, Jonathan M Coutinho, Paul J Nederkoorn and Yvo BWEM Roos in European Stroke Journal

Published
2023
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28. Hemorrhage rates in patients with acute ischemic stroke treated with intravenous alteplase and thrombectomy versus thrombectomy alone

Author

van Kranendonk, Katinka R, primary, Kappelhof, Manon, additional, Bruggeman, Agnetha A E, additional, Rinkel, Leon A, additional, Treurniet, Kilian M, additional, LeCouffe, Natalie, additional, Emmer, Bart J, additional, Coutinho, Jonathan M, additional, Wolff, Lennard, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, van der Lugt, Aad, additional, Dippel, Diederik W J, additional, Roos, Yvo B W E M, additional, Marquering, Henk A, additional, and Majoie, Charles B L M, additional

Published
2022
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29. Effect of Intravenous Alteplase Treatment on First-Line Stent Retriever Versus Aspiration Alone During Endovascular Treatment

Author

Rinkel, Leon A., primary, Treurniet, Kilian M., additional, Nieboer, Daan, additional, Kappelhof, Manon, additional, LeCouffe, Natalie E., additional, Bruggeman, Agnetha A.E., additional, van Zwam, Wim H., additional, Lycklama à Nijeholt, Geert J., additional, Ghariq, Elyas, additional, Uyttenboogaart, Maarten, additional, Dippel, Diederik W.J., additional, Roos, Yvo B.W.E.M., additional, Coutinho, Jonathan M., additional, Majoie, Charles B.L.M., additional, Emmer, Bart J., additional, Roozenbeek, Bob, additional, van Es, Adriaan, additional, de Ridder, Inger, additional, van der Worp, Bart, additional, Lo, Rob, additional, Keizer, Koos, additional, Gons, Rob, additional, Yo, Lonneke, additional, Boiten, Jelis, additional, van den Wijngaard, Ido, additional, Hofmeijer, Jeanette, additional, Martens, Jasper, additional, Schonewille, Wouter, additional, Albert Vos, Jan, additional, Tuladhar, Anil, additional, Schreuder, Floris, additional, Boogaarts, Jeroen, additional, Jenniskens, Sjoerd, additional, de Laat, Karlijn, additional, van Dijk, Lukas, additional, den Hertog, Heleen, additional, van Hasselt, Boudewijn, additional, Brouwers, Paul, additional, Sturm, Emiel, additional, Bulut, Tomas, additional, Remmers, Michel, additional, van Norden, Anouk, additional, de Jong, Thijs, additional, Rozeman, Anouk, additional, Elgersma, Otto, additional, Bokkers, Reinoud, additional, van Tuijl, Julia, additional, Boukrab, Issam, additional, Kortman, Hans, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Lemmens, Robin, additional, Demeestere, Jelle, additional, Desfontaines, Philippe, additional, Brisbois, Denis, additional, Clarençon, Frédéric, additional, Samson, Yves, additional, Brown, Martin, additional, White, Phil, additional, Gregson, John, additional, van Nuland, Rick, additional, van der Lugt, Aad, additional, Jacobi, Linda, additional, van den Berg, René, additional, Beenen, Ludo, additional, van Doormaal, Pieter-Jan, additional, Yoo, Albert, additional, Hammer, Bas, additional, Roosendaal, Stefan, additional, Meijer, Anton, additional, Krietemeijer, Menno, additional, van der Hoorn, Anouk, additional, Gerrits, Dick, additional, van Oostenbrugge, Robert, additional, Jansen, Ben, additional, Manschot, Sanne, additional, Kerkhof, Henk, additional, Koudstaal, Peter, additional, Lingsma, Hester, additional, Chalos, Vicky, additional, Berkhemer, Olvert, additional, Versteeg, Adriaan, additional, Wolff, Lennard, additional, Su, Jiahang, additional, Tolhuisen, Manon, additional, van Voorst, Henk, additional, ten Cate, Hugo, additional, de Maat, Moniek, additional, Donse-Donkel, Samantha, additional, van Beusekom, Heleen, additional, Taha, Aladdin, additional, van den Berg, Sophie, additional, van de Graaf, Rob, additional, Goldhoorn, Robert-Jan, additional, Hinsenveld, Wouter, additional, Pirson, Anne, additional, Sondag, Lotte, additional, Reinink, Rik, additional, Brouwer, Josje, additional, Collette, Sabine, additional, van der Steen, Wouter, additional, Sprengers, Rita, additional, Sterrenberg, Martin, additional, El Ghannouti, Naziha, additional, Verheesen, Sabrina, additional, Pellikaan, Wilma, additional, Blauwendraat, Kitty, additional, Drabbe, Yvonne, additional, de Meris, Joke, additional, Simons, Michelle, additional, Bongenaar, Hester, additional, van Loon, Anja, additional, Ponjee, Eva, additional, Eilander, Rieke, additional, Kooij, Suze, additional, de Jong, Marieke, additional, Santegoets, Esther, additional, Roodenburg, Suze, additional, van Ahee, Ayla, additional, Moynier, Marinette, additional, Devroye, Annemie, additional, Marcis, Evelyn, additional, Iezzi, Ingrid, additional, David, Annie, additional, Talbi, Atika, additional, Heiligers, Leontien, additional, and Martens, Yvonne, additional

Published
2022
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31. Time to Endovascular Treatment and Outcome in Acute Ischemic Stroke: MR CLEAN Registry Results

Author

Mulder, Maxim J.H.L., Jansen, Ivo G.H., Goldhoorn, Robert-Jan B., Venema, Esmee, Chalos, Vicky, Compagne, Kars C.J., Roozenbeek, Bob, Lingsma, Hester F., Schonewille, Wouter J., van den Wijngaard, Ido R., Boiten, Jelis, Albert Vos, Jan, Roos, Yvo B.W.EM., van Oostenbrugge, Robert J., van Zwam, Wim H., Majoie, Charles B.L.M., van der Lugt, Aad, Dippel, Diederik W.J., Vos, Jan Albert, Coutinho, Jonathan, Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper, Lycklamà Nijeholt, Geert J., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., van der Worp, H. Bart, Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Jeroen, de Kort, Paul L.M., Peluso, Jo, van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke, den Hertog, Heleen M., Sturm, Emiel J.C., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Roosendaal, Stefan, van der Kallen, Bas, van den Wijngaard, Ido, van Es, Ad, Emmer, Bart, Bot, Joost, van Doormaal, Pieter-Jan, Martens, Jasper M., Flach, H. Zwenneke, Ghannouti, Naziha el, Sterrenberg, Martin, Puppels, Corina, Pellikaan, Wilma, Sprengers, Rita, Elfrink, Marjan, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, van Rijswijk, Cathelijn, Messchendorp, Gert, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, Maureen, Ramakers, Daisy, Bos, Ernas, Drabbe, Yvonne, Zweedijk, Berber, Khalilzada, Mostafa, Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Hinsenveld, Wouter, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., Treurniet, Kilian M., Kappelhof, Manon, Tolhuijsen, Manon L., and Alves, Heitor

Published
2018
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32. Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke

Author

Alves, Heitor C., Treurniet, Kilian M., Dutra, Bruna G., Jansen, Ivo G. H., Boers, Anna M.M., Santos, Emilie M.M., Berkhemer, Olvert A., Dippel, Diederik W.J., van der Lugt, Aad, van Zwam, Wim H., van Oostenbrugge, Robert J., Lingsma, Hester F., Roos, Yvo B.W.E.M., Yoo, Albert J., Marquering, Henk A., and Majoie, Charles B.L.M.

Published
2018
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33. A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia

Author

Treurniet, Kilian M, Berkhemer, Olvert A, Immink, Rogier V, Lingsma, Hester F, Ward-van der Stam, Vivian M C, Hollmann, Markus W, Vuyk, Jaap, van Zwam, Wim H, van der Lugt, Aad, van Oostenbrugge, Robert J, Dippel, Diederik W J, Coutinho, Jonathan M, Roos, Yvo B W E M, Marquering, Henk A, Majoie, Charles B L M, Dippel, Diederik W J, Lugt, Aad van der, Majoie, Charles B L M, Roos, Yvo B W E M, van Oostenbrugge, Robert J, van Zwam, Wim H, Berkhemer, Olvert A, Fransen, Puck S S, Beumer, Debbie, van den Berg, Lucie A, Schonewille, Wouter J, Vos, Jan Albert, Majoie, Charles B L M, Roos, Yvo B W E M, Nederkoorn, Paul J, Wermer, Marieke J H, Walderveen, Marianne A A van, van Oostenbrugge, Robert J, van Zwam, Wim H, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A, Nijeholt, Geert J Lycklama à, Boiten, Jelis, Dippel, Diederik W J, Brouwer, Patrick A, Emmer, Bart J, de Bruijn, Sebastiaan F, van Dijk, Lukas C, Kappelle, L Jaap, Lo, Rob H, van Dijk, Ewoud J, de Vries, Joost, de Kort, Paul L M, van den Berg, Jan S P, van Rooij, Willem Jan J, van Hasselt, Boudewijn A A M, Aerden, Leo A M, Dallinga, René J, Visser, Marieke C, Bot, Joseph C J, Vroomen, Patrick C, Eshghi, Omid, Schreuder, Tobien H C M L, Heijboer, Roel J J, Keizer, Koos, Tielbeek, Alexander V, Hertog, Heleen M den, Gerrits, Dick G, van den Berg-Vos, Renske M, Karas, Giorgos B, Majoie, Charles B L M, van Zwam, Wim H, van der Lugt, Aad, Nijeholt, Geert J Lycklama à, van Walderveen, Marianne A A, Bot, Joseph C J, Marquering, Henk A, Beenen, Ludo F, Sprengers, Marieke E S, Jenniskens, Sjoerd F M, van den Berg, René, Berkhemer, Olvert A, Yoo, Albert J, Roos, Yvo B W E M, Koudstaal, Peter J, Boiten, Jelis, van Dijk, Ewoud J., van Oostenbrugge, Robert J, Wermer, Marieke J H, Flach, H Zwenneke, Steyerberg, Ewout W, and Lingsma, Hester F

Published
2018
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34. Determinants of Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: A Retrospective Cohort Study

Author

van der Steen, Wouter, primary, van der Ende, Nadinda A.M., additional, van Kranendonk, Katinka R., additional, Chalos, Vicky, additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Doormaal, Pieter J., additional, van Es, Adriaan C.G.M., additional, Lingsma, Hester F., additional, Majoie, Charles B.L.M., additional, van der Lugt, Aad, additional, Dippel, Diederik W.J., additional, Roozenbeek, Bob, additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Bulut, Tomas, additional, Brouwers, Paul J.A.M., additional, Lycklama, Geert J., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Vos, Jan Albert, additional, Bot, Joost, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Dinkelaar, Wouter, additional, Auke, P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte- Terreros, Nerea, additional, Ramos, Lucas A., additional, Brown, Martin M., additional, Liebig, Thomas, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont- Stikkelbroeck, Jose, additional, Haaglanden, MC, additional, Janssen, Kirsten, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Lucas, Marit, additional, Geuskens, Ralph Renan, additional, and Sales Barros, Roeland, additional

Published
2022
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35. Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry

Author

Pirson, F.A.V. (Anne), primary, Boodt, Nikki, additional, Brouwer, Josje, additional, Bruggeman, Agnetha A.E., additional, Hinsenveld, Wouter H., additional, Staals, Julie, additional, van Zwam, Wim H., additional, van der Leij, Christiaan, additional, Brans, Rutger J.B., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Schonewille, Wouter J., additional, van Oostenbrugge, Robert J., additional, Roos, Yvo B.W.E.M., additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, den Hartog, Sanne J., additional, Roozenbeek, Bob, additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Vos, Jan Albert, additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, van Es, Adriaan C.G.M., additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Bart van der Worp, H., additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Menno Krietemeijer, G., additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Cornelissen, Sandra, additional, Brans, Rutger, additional, Zwenneke Flach, H., additional, Lingsma, Hester F., additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, Ramos, Lucas A., additional, and Pirson, Anne F.A.V., additional

Published
2022
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37. Estimation of treatment effects in observational stroke care data: comparison of statistical approaches

Author

Amini, Marzyeh, van Leeuwen, Nikki, Eijkenaar, Frank, van de Graaf, Rob, Samuels, Noor, van Doormaal, Pieter Jan, Roozenbeek, Bob, Dippel, Diederik W.J., Lingsma, Hester F., van der Lugt, Aad, Vos, Jan Albert, Brouwer, Josje, den Hartog, Sanne J., Hinsenveld, Wouter H., Kappelhof, Manon, Compagne, Kars C.J., Goldhoorn, Robert Jan B., Mulder, Maxim J.H.L., Jansen, Ivo G.H., Emmer, Bart J., de Bruijn, Sebastiaan F., de Vries, J., Fransen, Puck, den Hertog, Heleen M., Brouwers, Paul, Jenniskens, Sjoerd F.M., Roosendaal, Stefan D., Ghariq, Elyas, Dinkelaar, Wouter, el Ghannouti, Naziha, Sterrenberg, Martin, Sprengers, Rita, Verheesen, Sabrina, Khalilzada, Mostafa, Venema, Esmee, Chalos, Vicky, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Berkhemer, Olvert A., Treurniet, Kilian M., LeCouffe, Natalie E., Radiology and nuclear medicine, ACS - Atherosclerosis & ischemic syndromes, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, MUMC+: Hersen en Zenuw Centrum (3), RS: Carim - B05 Cerebral small vessel disease, Clinical Neurophysiology, TechMed Centre, Public Health, Health Systems and Insurance (HSI), Radiology & Nuclear Medicine, Neurology, Neurosciences, Erasmus School of Law, General Practice, Emergency Medicine, Intensive Care, Erasmus MC other, Medical Oncology, Amsterdam Neuroscience - Neurovascular Disorders, Radiology and Nuclear Medicine, and ACS - Microcirculation

Subjects
Epidemiology, Acute ischemic stroke, General anesthesia, Health Informatics, ADJUSTMENT, Intravenous thrombolysis, GENERAL-ANESTHESIA, Fibrinolytic Agents, CONSCIOUS SEDATION, Humans, Thrombolytic Therapy, ACUTE ISCHEMIC-STROKE, Unmeasured confounding, OUTCOMES, Confounding by indication, BINARY DATA, Fibrinolytic Agents/therapeutic use, Endovascular Procedures, Other Research Radboud Institute for Health Sciences [Radboudumc 0], THROMBECTOMY, INSTRUMENTAL VARIABLE METHODS, Stroke, Endovascular Procedures/methods, PROPENSITY SCORE, Instrumental variable, Treatment Outcome, ENDOVASCULAR TREATMENT, Statistical approaches, Ecological-analysis, Stroke/drug therapy
Abstract

Introduction Various statistical approaches can be used to deal with unmeasured confounding when estimating treatment effects in observational studies, each with its own pros and cons. This study aimed to compare treatment effects as estimated by different statistical approaches for two interventions in observational stroke care data. Patients and methods We used prospectively collected data from the MR CLEAN registry including all patients (n = 3279) with ischemic stroke who underwent endovascular treatment (EVT) from 2014 to 2017 in 17 Dutch hospitals. Treatment effects of two interventions – i.e., receiving an intravenous thrombolytic (IVT) and undergoing general anesthesia (GA) before EVT – on good functional outcome (modified Rankin Scale ≤2) were estimated. We used three statistical regression-based approaches that vary in assumptions regarding the source of unmeasured confounding: individual-level (two subtypes), ecological, and instrumental variable analyses. In the latter, the preference for using the interventions in each hospital was used as an instrument. Results Use of IVT (range 66–87%) and GA (range 0–93%) varied substantially between hospitals. For IVT, the individual-level (OR ~ 1.33) resulted in significant positive effect estimates whereas in instrumental variable analysis no significant treatment effect was found (OR 1.11; 95% CI 0.58–1.56). The ecological analysis indicated no statistically significant different likelihood (β = − 0.002%; P = 0.99) of good functional outcome at hospitals using IVT 1% more frequently. For GA, we found non-significant opposite directions of points estimates the treatment effect in the individual-level (ORs ~ 0.60) versus the instrumental variable approach (OR = 1.04). The ecological analysis also resulted in a non-significant negative association (0.03% lower probability). Discussion and conclusion Both magnitude and direction of the estimated treatment effects for both interventions depend strongly on the statistical approach and thus on the source of (unmeasured) confounding. These issues should be understood concerning the specific characteristics of data, before applying an approach and interpreting the results. Instrumental variable analysis might be considered when unobserved confounding and practice variation is expected in observational multicenter studies.

Published
2022
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38. Effect of Intravenous Alteplase Treatment on First-Line Stent Retriever Versus Aspiration Alone During Endovascular Treatment

Author

Rinkel, Leon A, Treurniet, Kilian M, Nieboer, Daan, Kappelhof, Manon, LeCouffe, Natalie E, Bruggeman, Agnetha A E, van Zwam, Wim H, Lycklama À Nijeholt, Geert J, Ghariq, Elyas, Uyttenboogaart, Maarten, Dippel, Diederik W J, Roos, Yvo B W E M, Coutinho, Jonathan M, Majoie, Charles B L M, Emmer, Bart J, MR CLEAN-NO IV Investigators, Rinkel, Leon A, Treurniet, Kilian M, Nieboer, Daan, Kappelhof, Manon, LeCouffe, Natalie E, Bruggeman, Agnetha A E, van Zwam, Wim H, Lycklama À Nijeholt, Geert J, Ghariq, Elyas, Uyttenboogaart, Maarten, Dippel, Diederik W J, Roos, Yvo B W E M, Coutinho, Jonathan M, Majoie, Charles B L M, Emmer, Bart J, and MR CLEAN-NO IV Investigators

Abstract

BACKGROUND: We aimed to assess whether the effect of intravenous alteplase treatment (IVT) before endovascular treatment (EVT) on outcome is modified by first-line technique during EVT in IVT eligible patients.METHODS: This was a post hoc analysis from MR CLEAN-NO IV (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands - Intravenous Treatment Followed by Intra-Arterial Treatment Versus Direct Intra-Arterial Treatment for Acute Ischemic Stroke Caused by a Proximal Intracranial Occlusion), a randomized trial of IVT followed by EVT versus EVT alone in patients presenting directly to EVT-capable centers. We included data from all patients who underwent EVT with a thrombectomy attempt. We compared patients treated with stent retriever (with or without aspiration) to aspiration alone as first-line EVT technique and assessed the interaction of first-line EVT technique with IVT treatment. Primary outcome was the 90-day modified Rankin Scale score, analyzed with mixed model ordinal regression for a shift towards better outcome. Secondary outcomes included successful reperfusion (extended Thrombolysis in Cerebral Infarction score 2b-3).RESULTS: Of 473 included patients, 102 (21.6%) were treated with aspiration alone as first-line technique. In the full population, functional outcome was similar for patients treated with stent retriever versus aspiration only (adjusted common odds ratio [acOR]' 1.07 [95% CI, 0.69-1.66]). We observed a significant interaction between IVT and first-line EVT technique (P=0.03). In the aspiration-only group, patients treated with EVT alone had worse functional outcome compared to those treated with IVT and EVT (acOR, 0.44 [95% CI, 0.21-0.90]). In the stent retriever group, functional outcome did not differ between patients treated with or without IVT (acOR, 1.08 [95% CI, 0.74-1.57]). There was no statistically significant interaction for successful reperfusion.CONCLUS

Published
2022

40. Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry

Author

Compagne, Kars C.J., primary, Kappelhof, Manon, additional, Hinsenveld, Wouter H., additional, Brouwer, Josje, additional, Goldhoorn, Robert-Jan B., additional, Uyttenboogaart, Maarten, additional, Bokkers, Reinoud P.H., additional, Schonewille, Wouter J., additional, Martens, Jasper M., additional, Hofmeijer, Jeannette, additional, van der Worp, H. Bart, additional, Lo, Rob T.H., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, Lycklama à Nijeholt, Geert J., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, van Walderveen, Marianne A.A., additional, Wermer, Marieke J.H., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Boogaarts, Hieronymus D., additional, van Dijk, Ewout J., additional, van Tuijl, Julia H., additional, Peluso, Jo P.P., additional, de Kort, Paul L.M., additional, van Hasselt, Boudewijn A.A.M., additional, Fransen, Puck S., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Jenniskens, Sjoerd F.M., additional, Sprengers, Marieke E.S., additional, Ghariq, Elias, additional, van den Wijngaard, Ido R., additional, Roosendaal, Stefan D., additional, Meijer, Anton F.J.A., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, van den Berg, René, additional, Yoo, Albert J., additional, van Doormaal, Pieter Jan, additional, van Proosdij, Marc P., additional, Krietemeijer, Menno G.M., additional, Gerrits, Dick G., additional, Hammer, Sebastiaan, additional, Vos, Jan Albert, additional, Boiten, Jelis, additional, Coutinho, Jonathan M., additional, Emmer, Bart J., additional, van Es, Ad C.G.M., additional, Roozenbeek, Bob, additional, Roos, Yvo B.W.E.M., additional, van Zwam, Wim H., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, den Hartog, Sanne J., additional, Albert Vos, Jan, additional, Staals, Julie, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, de Vries, J., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Eschgi, Omid, additional, Bulut, Tomas, additional, van der Kallen, Bas F.W., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, Lo, Rob, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Lingsma, Hester F., additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional

Published
2022
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41. Fully Automated Thrombus Segmentation on CT Images of Patients with Acute Ischemic Stroke

Author

Mojtahedi, Mahsa, primary, Kappelhof, Manon, additional, Ponomareva, Elena, additional, Tolhuisen, Manon, additional, Jansen, Ivo, additional, Bruggeman, Agnetha A. E., additional, Dutra, Bruna G., additional, Yo, Lonneke, additional, LeCouffe, Natalie, additional, Hoving, Jan W., additional, van Voorst, Henk, additional, Brouwer, Josje, additional, Terreros, Nerea Arrarte, additional, Konduri, Praneeta, additional, Meijer, Frederick J. A., additional, Appelman, Auke, additional, Treurniet, Kilian M., additional, Coutinho, Jonathan M., additional, Roos, Yvo, additional, van Zwam, Wim, additional, Dippel, Diederik, additional, Gavves, Efstratios, additional, Emmer, Bart J., additional, Majoie, Charles, additional, and Marquering, Henk, additional

Published
2022
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42. Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry

Author

Pirson, F. Anne V., primary, Boodt, Nikki, additional, Brouwer, Josje, additional, Bruggeman, Agnetha A.E., additional, den Hartog, Sanne J., additional, Goldhoorn, Robert-Jan B., additional, Langezaal, Lucianne C.M., additional, Staals, Julie, additional, van Zwam, Wim H., additional, van der Leij, Christiaan, additional, Brans, Rutger J.B., additional, Majoie, Charles B.L.M., additional, Coutinho, Jonathan M., additional, Emmer, Bart J., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Vos, Jan-Albert, additional, van Oostenbrugge, Robert J., additional, Schonewille, Wouter J., additional, Roos, Yvo B.W.E.M., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, Hinsenveld, Wouter H., additional, Roozenbeek, Bob, additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, van Es, Adriaan C.G.M., additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Menno Krietemeijer, G., additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Cornelissen, Sandra, additional, à Nijeholt, Geert J. Lycklama, additional, Flach, H. Zwenneke, additional, Lingsma, Hester F., additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional

Published
2022
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43. Endovascular treatment effect diminishes with increasing thrombus perviousness

Author

Kappelhof, Manon, Tolhuisen, Manon L., Treurniet, Kilian M., Dutra, Bruna G., Alves, Heitor, Zhang, Guang, Brown, Scott, Muir, Keith W., Dávalos, Antoni, Roos, Yvo B.W.E.M., Saver, Jeffrey L., Demchuk, Andrew M., Jovin, Tudor G., Bracard, Serge, Campbell, Bruce C.V., van der Lugt, Aad, Guillemin, Francis, White, Philip, Hill, Michael D., Dippel, Diederik W.J., Mitchell, Peter J., Goyal, Mayank, Marquering, Henk A., and Majoie, Charles B.L.M.

Subjects
Male, Computed Tomography Angiography, Original Contributions, decision making, Clinical and Population Sciences, Fibrinolytic Agents, Humans, tissue-type plasminogen activator, Aged, Ischemic Stroke, Thrombectomy, Clinical Trials as Topic, Endovascular Procedures, Thrombosis, Recovery of Function, Middle Aged, cerebral infarction, stroke, reperfusion, Tissue Plasminogen Activator, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Tomography, X-Ray Computed
Abstract

Supplemental Digital Content is available in the text., Background and Purpose: Thrombus perviousness estimates residual flow along a thrombus in acute ischemic stroke, based on radiological images, and may influence the benefit of endovascular treatment for acute ischemic stroke. We aimed to investigate potential endovascular treatment (EVT) effect modification by thrombus perviousness. Methods: We included 443 patients with thin-slice imaging available, out of 1766 patients from the pooled HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke trials) data set of 7 randomized trials on EVT in the early window (most within 8 hours). Control arm patients (n=233) received intravenous alteplase if eligible (212/233; 91%). Intervention arm patients (n=210) received additional EVT (prior alteplase in 178/210; 85%). Perviousness was quantified by thrombus attenuation increase on admission computed tomography angiography compared with noncontrast computed tomography. Multivariable regression analyses were performed including multiplicative interaction terms between thrombus attenuation increase and treatment allocation. In case of significant interaction, subgroup analyses by treatment arm were performed. Our primary outcome was 90-day functional outcome (modified Rankin Scale score), resulting in an adjusted common odds ratio for a one-step shift towards improved outcome. Secondary outcomes were mortality, successful reperfusion (extended Thrombolysis in Cerebral Infarction score, 2B–3), and follow-up infarct volume (in mL). Results: Increased perviousness was associated with improved functional outcome. After adding a multiplicative term of thrombus attenuation increase and treatment allocation, model fit improved significantly (P=0.03), indicating interaction between perviousness and EVT benefit. Control arm patients showed significantly better outcomes with increased perviousness (adjusted common odds ratio, 1.2 [95% CI, 1.1–1.3]). In the EVT arm, no significant association was found (adjusted common odds ratio, 1.0 [95% CI, 0.9–1.1]), and perviousness was not significantly associated with successful reperfusion. Follow-up infarct volume (12% [95% CI, 7.0–17] per 5 Hounsfield units) and chance of mortality (adjusted odds ratio, 0.83 [95% CI, 0.70–0.97]) decreased with higher thrombus attenuation increase in the overall population, without significant treatment interaction. Conclusions: Our study suggests that the benefit of best medical care including alteplase, compared with additional EVT, increases in patients with more pervious thrombi.

Published
2021

44. Clot Burden Score on Baseline Computerized Tomographic Angiography and Intra-Arterial Treatment Effect in Acute Ischemic Stroke

Author

Treurniet, Kilian M., Yoo, Albert J., Berkhemer, Olvert A., Lingsma, Hester F., Boers, Anna M.M., Fransen, Puck S.S., Beumer, Debbie, van den Berg, Lucie A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Lycklama À Nijeholt, Geert J., van Walderveen, Marianne A.A., Bot, Joseph C.J., Beenen, Ludo F.M., van den Berg, René, van Zwam, Wim H., van der Lugt, Aad, van Oostenbrugge, Robert J., Dippel, Diederik W.J., Roos, Yvo B.W.E.M., Marquering, Henk A., Majoie, Charles B.L.M., Schonewille, Wouter J., Albert Vos, Jan, Nederkoorn, Paul J., Wermer, Marieke J.H., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van den Berg, Jan S.P., van Rooij, Willem Jan J., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Koudstaal, Peter J., Boiten, Jelis, van Dijk, Ewoud J., Wermer, Marieke J.H., Flach, H. Zwenneke, and Steyerberg, Ewout W

Published
2016
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45. Influence of Device Choice on the Effect of Intra-Arterial Treatment for Acute Ischemic Stroke in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands)

Author

Dippel, Diederik W., Majoie, Charles B., Roos, Yvo B., van der Lugt, Aad, van Oostenbrugge, Robert J., van Zwam, Wim H., Lingsma, Hester F., Koudstaal, Peter J., Treurniet, Kilian M., van den Berg, Lucie A., Beumer, Debbie, Fransen, Puck S., and Berkhemer, Olvert A.

Published
2016
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47. Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke

Author

Santos, Emilie M.M., Marquering, Henk A., den Blanken, Mark D., Berkhemer, Olvert A., Boers, Anna M.M., Yoo, Albert J., Beenen, Ludo F., Treurniet, Kilian M., Wismans, Carrie, van Noort, Kim, Lingsma, Hester F., Dippel, Diederik W.J., van der Lugt, Aad, van Zwam, Wim H., Roos, Yvo B.W.E.M., van Oostenbrugge, Robert J., Niessen, Wiro J., and Majoie, Charles B.

Published
2016
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48. Hospital Variation in Time to Endovascular Treatment for Ischemic Stroke: What Is the Optimal Target for Improvement?

Author

den Hartog, Sanne J., primary, Lingsma, Hester F., additional, van Doormaal, Pieter‐Jan, additional, Hofmeijer, Jeannette, additional, Yo, Lonneke S. F., additional, Majoie, Charles B. L. M., additional, Dippel, Diederik W. J., additional, van der Lugt, Aad, additional, Roozenbeek, Bob, additional, Roos, Yvo B. W. E. M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Jansen, Ivo G. H., additional, Mulder, Maxim J. H. L., additional, Goldhoorn, Robert‐ Jan B., additional, Compagne, Kars C. J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, van Es, Adriaan C. G. M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L. M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P. H., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Brouwers, Paul J. A. M., additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F. W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Menno Krietemeijer, G., additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P. A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Zwenneke Flach, H, additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Huguet, J., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L. F., additional, Voogd, Eva J. H. F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E. D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte‐Terreros, Nerea, additional, and Ramos, Lucas A., additional

Published
2021
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49. A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke

Author

LeCouffe, Natalie E., primary, Kappelhof, Manon, additional, Treurniet, Kilian M., additional, Rinkel, Leon A., additional, Bruggeman, Agnetha E., additional, Berkhemer, Olvert A., additional, Wolff, Lennard, additional, van Voorst, Henk, additional, Tolhuisen, Manon L., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, van Es, Adriaan C.G.M., additional, Boiten, Jelis, additional, Lycklama à Nijeholt, Geert J., additional, Keizer, Koos, additional, Gons, Rob A.R., additional, Yo, Lonneke S.F., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Roozenbeek, Bob, additional, van der Worp, H. Bart, additional, Lo, Rob T.H., additional, van den Wijngaard, Ido R., additional, de Ridder, Inger R., additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Lemmens, Robin, additional, Demeestere, Jelle, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Schonewille, Wouter J., additional, Vos, Jan-Albert, additional, Uyttenboogaart, Maarten, additional, Bokkers, Reinoud P.H., additional, van Tuijl, Julia H., additional, Kortman, Hans, additional, Schreuder, Floris H.B.M., additional, Boogaarts, Hieronymus D., additional, de Laat, Karlijn F., additional, van Dijk, Lukas C., additional, den Hertog, Heleen M., additional, van Hasselt, Boudewijn A.A.M., additional, Brouwers, Paul J.A.M., additional, Bulut, Tomas, additional, Remmers, Michel J.M., additional, van Norden, Anouk, additional, Imani, Farshad, additional, Rozeman, Anouk D., additional, Elgersma, Otto E.H., additional, Desfontaines, Philippe, additional, Brisbois, Denis, additional, Samson, Yves, additional, Clarençon, Frédéric, additional, Krietemeijer, G. Menno, additional, Postma, Alida A., additional, van Doormaal, Pieter-Jan, additional, van den Berg, René, additional, van der Hoorn, Anouk, additional, Beenen, Ludo F.M., additional, Nieboer, Daan, additional, Lingsma, Hester F., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Majoie, Charles B.L.M., additional, and Roos, Yvo B.W.E.M., additional

Published
2021
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