183 results on '"Treston, Anthony"'
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2. Iminosugars: A host-targeted approach to combat Flaviviridae infections
3. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
4. Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo
5. Recent Molecular Advances in the Approach to Early Lung Cancer Detection and Intervention
6. Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects
7. Identification of Endoplasmic Reticulum α-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design
8. Investigational New Drug Enabling Nonclinical Safety Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent
9. Investigational New Drug Enabling Nonclinical Safety Pharmacology Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent
10. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
11. Growth Factors and Other Targets for Rational Application as Intervention Agents
12. N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity
13. Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure–activity relationships compared to 2-methoxyestradiol
14. Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples
15. A Mitogenic Peptide Amide Encoded within the E Peptide Domain of the Insulin-Like Growth Factor IB Prohormone
16. A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate
17. A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
18. Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity
19. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
20. Synthesis and structure–activity relationships of 16-modified analogs of 2-methoxyestradiol
21. Differential Expression of the Early Lung Cancer Detection Marker, Heterogeneous Nuclear Ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in Normal Breast and Neoplastic Breast Cancer
22. 2-Methoxyestradiol: an Endogenous Antiangiogenic and Antiproliferative Drug Candidate
23. Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections
24. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
25. Peptidylglycine α-amidating monooxygenase (PAM) immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary tumours
26. GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens
27. Expression of Heterogeneous Nuclear Ribonucleoprotein A2/B1 Changes with Critical Stages of Mammalian Lung Development
28. Growth Control of Lung Cancer by Interruption of 5-Lipoxygenase-mediated Growth Factor Signaling
29. Scientific basis for cancer prevention: intermediate cancer markers
30. Initiators and promoters of lung cancer
31. Autocrine growth loops dependent on peptidyl α-amidating enzyme as targets for novel tumor cell growth inhibitors
32. Autocrine Growth Factors and Lung Cancer
33. Expression of Peptidyl-Glycine α-amidating Mono-Oxygenase (PAM) Enzymes in Morphological Abnormalities Adjecent to Pulmonary Tumors
34. Distribution of Peptidyl-Glycine a-Amidatyng
35. Autocrine Growth Factors and Lung Cancer
36. Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs
37. Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol
38. A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate
39. A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
40. Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198
41. Synthesis and in Vivo Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate, 17-Phosphate, and 3,17-Diphosphate
42. 2-Methoxyestradiol in Combination with Velcade® Results in an Augmentation of NFκB Inhibition, In Vitro Antiproliferative Activity and In Vivo Antitumor Efficacy in the RPMI-8226 Myeloma Model.
43. A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer
44. Peptidylglycine ?-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
45. Synthesis and Enantiomeric Separation of 2-Phthalimidino-glutaric Acid Analogues: Potent Inhibitors of Tumor Metastasis
46. Immunocytochemical Mapping of the Amidating Enzyme PAM in the Developing and Adult Mouse Lung
47. Peptide-amidating Enzymes Are Expressed in the Stellate Epithelial Cells of the Thymic Medulla
48. NEW APPROACHES TO THE INTEGRATED MANAGEMENT OF EARLY LUNG CANCER
49. Rapid mass spectrometric identification of proteins from two-dimensional polyacrylamide gels after in gel proteolytic digestion
50. Where does amidation take place?
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