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151 results on '"Tresserra, Francesc"'

1. Converging and evolving immuno-genomic routes toward immune escape in breast cancer

Author

Blanco-Heredia, Juan, Souza, Carla Anjos, Trincado, Juan L., Gonzalez-Cao, Maria, Gonçalves-Ribeiro, Samuel, Gil, Sara Ruiz, Pravdyvets, Dmytro, Cedeño, Samandhy, Callari, Maurizio, Marra, Antonio, Gazzo, Andrea M., Weigelt, Britta, Pareja, Fresia, Vougiouklakis, Theodore, Jungbluth, Achim A., Rosell, Rafael, Brander, Christian, Tresserra, Francesc, Reis-Filho, Jorge S., Tiezzi, Daniel Guimarães, de la Iglesia, Nuria, Heyn, Holger, and De Mattos-Arruda, Leticia

Published
2024
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17. Reference standards for gene fusion molecular assays on cytological samples: an international validation study

Author

Malapelle, U, Pepe, F, Pisapia, P, Altimari, A, Bellevicine, C, Brunnström, H, Bruno, R, Büttner, R, Cirnes, L, De Andrea, C, de Biase, D, Dumur, C, Ericson Lindquist, K, Fontanini, G, Gautiero, E, Gentien, D, Hofman, P, Hofman, V, Iaccarino, A, Lozano, M, Mayo-de-Las-Casas, C, Merkelbach-Bruse, S, Pagni, F, Roman, R, Schmitt, F, Siemanowski, J, Roy-Chowdhuri, S, Tallini, G, Tresserra, F, Vander Borght, S, Vielh, P, Vigliar, E, Vita, G, Weynand, B, Rosell, R, Molina Vila, M, Troncone, G, Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, Troncone, Giancarlo, Malapelle, U, Pepe, F, Pisapia, P, Altimari, A, Bellevicine, C, Brunnström, H, Bruno, R, Büttner, R, Cirnes, L, De Andrea, C, de Biase, D, Dumur, C, Ericson Lindquist, K, Fontanini, G, Gautiero, E, Gentien, D, Hofman, P, Hofman, V, Iaccarino, A, Lozano, M, Mayo-de-Las-Casas, C, Merkelbach-Bruse, S, Pagni, F, Roman, R, Schmitt, F, Siemanowski, J, Roy-Chowdhuri, S, Tallini, G, Tresserra, F, Vander Borght, S, Vielh, P, Vigliar, E, Vita, G, Weynand, B, Rosell, R, Molina Vila, M, Troncone, G, Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, and Troncone, Giancarlo

Abstract

AIMS: Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. METHODS: Cell lines harbouring EML4(13)-ALK(20) and SLC34A2(4)-ROS1(32) gene fusions were adopted to prepare reference standards. Eight laboratories (five adopting amplicon-based and three hybridisation-based platforms) received, at different dilution points two sets of slides (slide A 50.0%, slide B 25.0%, slide C 12.5% and slide D wild type) stained by Papanicolaou (Pap) and May Grunwald Giemsa (MGG). Analysis was carried out on a total of 64 slides. RESULTS: Four (50.0%) out of eight laboratories reported results on all slides and dilution points. While 12 (37.5%) out of 32 MGG slides were inadequate, 27 (84.4%) out of 32 Pap slides produced libraries adequate for variant calling. The laboratories using hybridisation-based platforms showed the highest rate of inadequate results (13/24 slides, 54.2%). Conversely, only 10.0% (4/40 slides) of inadequate results were reported by laboratories adopting amplicon-based platforms. CONCLUSIONS: Reference standards in cytological format yield better results when Pap staining and processed by amplicon-based assays. Further investigation is required to optimise these standards for MGG stained cells and for hybridisation-based approaches.

Published
2023

27. Consenso sobre la biopsia selectiva del ganglio centinela en el cáncer de mama. Revisión 2013 de la Sociedad Española de Senología y Patología Mamaria

Author

Bernet, Laia, Piñero, Antonio, Vidal-Sicart, Sergi, Peg, Vicente, Giménez, Julia, Algara, Manuel, Dueñas, Basilio, Tresserra, Francesc, Cano, Rafael, Cordero, José Manuel, Navarro, Beatriz, Torró, Josep, Pardo, Ricardo, Martínez Ramos, David, Moreno Elola, Arantxa, Vallejos, Virginia, Vázquez, Carlos, Alvarez Benito, Marina, Raya Povedano, Jose Luis, Carreira Gómez, Carmen, Galobardes Monge, Josefa, Iglesias, Edelmiro, Fuster, Carlos, Lluch, Ana, and Martinez Agulló, Angel

Published
2014
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28. Orbital histiocytosis with systemic involvement: A case with complex affiliations

Author

Civit, Joaquín J.R., Godoy, Davinia, Conde, Alicia, Arencibia, Jorge, Medel, Ramón, Limeres, Miguel A., Miguel, Iñigo S., Marín, José D., Aguilar, Y., Tresserra, Francesc, and Medina, Francisco

Subjects
genetic structures, Erdheim–Chester disease, Rosai–Dorfman disease, systemic histiocytosis, Case Report, orbital histiocytosis, eye diseases, Non-Langerhans cell histiocytosis
Abstract

A 70-year-old male presented with orbital masses affecting the muscular cone. His past medical history was notable for diabetes mellitus, ischemic cardiopathy, sleep-apnea syndrome, and multiple serous effusions. The first biopsy specimen of affected orbital tissue revealed fibrohistiocytic infiltration resembling xanthogranuloma or Erdheim–Chester disease (ECD). An ulterior biopsy of affected orbital tissue showed lymphocyte emperipolesis with immunopositivity for CD68 and S100 but negative staining for CD1a marker, strongly suggesting Rosai–Dorfman disease (RDD). Afterward, pericardium and peritoneal effusions resulted in constrictive pericarditis and retroperitoneal fibrosis, respectively. The absence of distinctive clinical features made the diagnosis especially challenging. Attempts to control the disease using corticosteroids, radiation, orbital surgery, and interferon were unsuccessful. Aggressive treatments such as chemotherapy were not considered appropriate due to the general deterioration of our patient. Although the possibility of two concurrent diseases (e.g., systemic ECD and orbital RDD) cannot be discarded, we interpreted the orbital findings as likely due to RDD, and the entire condition of our patient as an extranodal RDD with atypical clinicopathological findings and outcome.

Published
2021

30. Soemmerring’s Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas

Author

D’Antin, Justin Christopher, Tresserra, Francesc, Barraquer, Rafael I., Michael, Ralph, D’Antin, Justin Christopher, Tresserra, Francesc, Barraquer, Rafael I., and Michael, Ralph

Abstract

Soemmerring’s rings consist of a ring of lens epithelial derived cells that grow along the periphery of an aphakic lens capsule, or around an intraocular lens. These rings when visualized frontally, appear opaque, however, in some cases the cells that compose these rings are organized in the same fashion as those in normal transparent adult lenses. Thus, our purpose was to test whether any part of the adult Soemmerring’s ring could be transparent and how this related to morphological factors. To study this, 16 Soemmerring’s rings were extracted from donor eye globes. After imaging, they were thickly sectioned sagittally in order to analyze the degrees of transparency of different areas. All samples were also histologically analyzed using alpha smooth muscle actin, Vimentin, wheat germ agglutinin and DAPI. Our results showed that many samples had some transparent areas, mostly towards the center of their cross-section. Of the factors that we analyzed, only lens fiber organization at the bow region and an increased area of mature lens fiber cells had a significant relation to the degree of transparency at the center. Thus, we can conclude that as Soemmerring’s rings mature, they can develop organized and transparent areas of lens cells.

Published
2022

31. Soemmerring's Rings Developed around IOLs, in Human Donor Eyes, Can Present Internal Transparent Areas.

Author

D'Antin, Justin Christopher, Tresserra, Francesc, Barraquer, Rafael I., and Michael, Ralph

Subjects
*INTRAOCULAR lenses, *WHEAT germ, *SMOOTH muscle, *EPITHELIAL cells, *VIMENTIN
Abstract

Soemmerring's rings consist of a ring of lens epithelial derived cells that grow along the periphery of an aphakic lens capsule, or around an intraocular lens. These rings when visualized frontally, appear opaque, however, in some cases the cells that compose these rings are organized in the same fashion as those in normal transparent adult lenses. Thus, our purpose was to test whether any part of the adult Soemmerring's ring could be transparent and how this related to morphological factors. To study this, 16 Soemmerring's rings were extracted from donor eye globes. After imaging, they were thickly sectioned sagittally in order to analyze the degrees of transparency of different areas. All samples were also histologically analyzed using alpha smooth muscle actin, Vimentin, wheat germ agglutinin and DAPI. Our results showed that many samples had some transparent areas, mostly towards the center of their cross-section. Of the factors that we analyzed, only lens fiber organization at the bow region and an increased area of mature lens fiber cells had a significant relation to the degree of transparency at the center. Thus, we can conclude that as Soemmerring's rings mature, they can develop organized and transparent areas of lens cells. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Reference standards for gene fusion molecular assays on cytological samples: an international validation study

Author

Malapelle, Umberto, primary, Pepe, Francesco, additional, Pisapia, Pasquale, additional, Altimari, Annalisa, additional, Bellevicine, Claudio, additional, Brunnström, Hans, additional, Bruno, Rossella, additional, Büttner, Reinhard, additional, Cirnes, Luis, additional, De Andrea, Carlos E, additional, de Biase, Dario, additional, Dumur, Catherine I, additional, Ericson Lindquist, Kajsa, additional, Fontanini, Gabriella, additional, Gautiero, Eugenio, additional, Gentien, David, additional, Hofman, Paul, additional, Hofman, Veronique, additional, Iaccarino, Antonino, additional, Lozano, Maria Dolores, additional, Mayo-de-Las-Casas, Clara, additional, Merkelbach-Bruse, Sabine, additional, Pagni, Fabio, additional, Roman, Ruth, additional, Schmitt, Fernando C, additional, Siemanowski, Janna, additional, Roy-Chowdhuri, Sinchita, additional, Tallini, Giovanni, additional, Tresserra, Francesc, additional, Vander Borght, Sara, additional, Vielh, Philippe, additional, Vigliar, Elena, additional, Vita, Giulia Anna Carmen, additional, Weynand, Birgit, additional, Rosell, Rafael, additional, Molina Vila, Miguel Angel, additional, and Troncone, Giancarlo, additional

Published
2021
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35. Labral reconstruction with tendon allograft : histological findings show revascularization at 8 weeks from implantation

Author

Gómez, Esther Moya, Cardenas, Carlomagno, Astarita, Emmanuelle, Bellotti, Vittorio, Tresserra, Francesc, Natera, Luis Gerardo, Ribas, Manel, and Universitat Autònoma de Barcelona

Subjects
musculoskeletal diseases, 030222 orthopedics, medicine.medical_specialty, business.industry, medicine.medical_treatment, Postoperative complication, Revascularization, Peroneus brevis tendon, Tendon, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, surgical procedures, operative, medicine, 030212 general & internal medicine, Radiology, business, Research Articles
Abstract

This description shows the histological findings of a peroneus brevis tendon allograft used for labral reconstruction, implanted 8 weeks before being retrieved due to a postoperative complication unrelated to the graft. As far as we have knowledge this is the first description about revascularization of an allograft used for hip labral reconstruction. The histological report of the removed peroneus brevis tendon allograft shows evidence of vascular ingrowth represented by small vessels with a thin muscular wall in all layers of the graft and cellular migration mainly represented by mature fibroblasts.

Published
2021

36. Reference standards for gene fusion molecular assays on cytological samples: an international validation study

Author

Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnstro¨m, Hans, Bruno, Rossella, Bu¨ttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, and Troncone, Giancarlo

Abstract

AimsGene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated.MethodsCell lines harbouring EML4(13)–ALK(20) and SLC34A2(4)–ROS1(32) gene fusions were adopted to prepare reference standards. Eight laboratories (five adopting amplicon-based and three hybridisation-based platforms) received, at different dilution points two sets of slides (slide A 50.0%, slide B 25.0%, slide C 12.5% and slide D wild type) stained by Papanicolaou (Pap) and May Grunwald Giemsa (MGG). Analysis was carried out on a total of 64 slides.ResultsFour (50.0%) out of eight laboratories reported results on all slides and dilution points. While 12 (37.5%) out of 32 MGG slides were inadequate, 27 (84.4%) out of 32 Pap slides produced libraries adequate for variant calling. The laboratories using hybridisation-based platforms showed the highest rate of inadequate results (13/24 slides, 54.2%). Conversely, only 10.0% (4/40 slides) of inadequate results were reported by laboratories adopting amplicon-based platforms.ConclusionsReference standards in cytological format yield better results when Pap staining and processed by amplicon-based assays. Further investigation is required to optimise these standards for MGG stained cells and for hybridisation-based approaches.

Published
2023
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41. Detection of somatic mutations in peritoneal lavages and plasma of endometrial cancer patients: A proof‐of‐concept study

Author

Mayo‐de‐las‐Casas, Clara, primary, Velasco, Ana, additional, Sanchez, Douglas, additional, Martínez‐Bueno, Alejandro, additional, Garzón‐Ibáñez, Mónica, additional, Gatius, Sònia, additional, Ruiz‐Miró, Maria, additional, Gonzalez‐Tallada, Xavier, additional, Llordella, Ivana, additional, Tresserra, Francesc, additional, Rodríguez, Sonia, additional, Aldeguer, Erika, additional, Roman‐Canal, Berta, additional, Bertran‐Alamillo, Jordi, additional, García‐Peláez, Beatriz, additional, Rosell, Rafael, additional, Molina‐Vila, Miguel A., additional, and Matias‐Guiu, Xavier, additional

Published
2020
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44. Impaired Expression of Ectonucleotidases in Ectopic and Eutopic Endometrial Tissue Is in Favor of ATP Accumulation in the Tissue Microenvironment in Endometriosis

Author

Trapero, Carla, primary, Vidal, August, additional, Fernández-Montolí, Maria Eulàlia, additional, Coroleu, Buenaventura, additional, Tresserra, Francesc, additional, Barri, Pere, additional, Gómez de Aranda, Inmaculada, additional, Sévigny, Jean, additional, Ponce, Jordi, additional, Matias-Guiu, Xavier, additional, and Martín-Satué, Mireia, additional

Published
2019
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47. Ecto-nucleotidases as potential biomarkers for diagnosis of endometriosis

Author

Trapero, Carla, Vidal-Bel, August, Jover, Lluís, Fernández Montolí, Ma. Eulalia, García-Tejedor, Amparo, Ponce i Sebastià, Jordi, Tresserra, Francesc, Barri, Pere, Coroleu, Buenaventura, and Martín Satué, Mireia

Subjects
Ginecologia, Gynecology, Endometriosis, Endometriosi, Enzims, Enzymes
Abstract

Introduction: Endometriosis is an inflammatory disorder characterized by the growth of endometrial tissue in extrauterine locations. Ovarian endometriomas are a common form of endometriosis. Late diagnosis is the main problem in the pathology; thus, it is important to identify clinical biomarkers. Ecto-nucleotidases are enzymes that hydrolyze extracellular ATP to adenosine and are involved in many inflammatory processes. Alterations of ecto-nucleotidase activity are related to inflammatory disease states.

Published
2017

48. Orbital histiocytosis with systemic involvement: A case with complex affiliations.

Author

Civit, Joaquín J. R., Godoy, Davinia, Conde, Alicia, Arencibia, Jorge, Medel, Ramón, Limeres, Miguel A., Miguel, Iñigo S., Marín, José D., Aguilar, Y., Tresserra, Francesc, and Medina, Francisco

Abstract

A 70-year-old male presented with orbital masses affecting the muscular cone. His past medical history was notable for diabetes mellitus, ischemic cardiopathy, sleep-apnea syndrome, and multiple serous effusions. The first biopsy specimen of affected orbital tissue revealed fibrohistiocytic infiltration resembling xanthogranuloma or Erdheim-Chester disease (ECD). An ulterior biopsy of affected orbital tissue showed lymphocyte emperipolesis with immunopositivity for CD68 and S100 but negative staining for CD1a marker, strongly suggesting Rosai-Dorfman disease (RDD). Afterward, pericardium and peritoneal effusions resulted in constrictive pericarditis and retroperitoneal fibrosis, respectively. The absence of distinctive clinical features made the diagnosis especially challenging. Attempts to control the disease using corticosteroids, radiation, orbital surgery, and interferon were unsuccessful. Aggressive treatments such as chemotherapy were not considered appropriate due to the general deterioration of our patient. Although the possibility of two concurrent diseases (e.g., systemic ECD and orbital RDD) cannot be discarded, we interpreted the orbital findings as likely due to RDD, and the entire condition of our patient as an extranodal RDD with atypical clinicopathological findings and outcome. [ABSTRACT FROM AUTHOR]

Published
2020
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