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3. Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure

Author

Fan, Zheng, Karakone, Mara, Nagarajan, Shunmugam, Nagy, Nadine, Mildenberger, Wiebke, Petrova, Ekaterina, Hinte, Laura Catharina, Bijnen, Mitchell, Häne, Philipp, Nelius, Eric, Chen, Jing, Ferapontova, Irina, von Meyenn, Ferdinand, Trepiccione, Francesco, Berber, Mesut, Ribas, David Penton, Eichmann, Anne, Zennaro, Maria-Christina, Takeda, Norihiko, Fischer, Jens W., Spyroglou, Ariadni, Reincke, Martin, Beuschlein, Felix, Loffing, Johannes, Greter, Melanie, and Stockmann, Christian

Published
2024
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4. RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome

Author

Sambri, Irene, Ferniani, Marco, Campostrini, Giulia, Testa, Marialuisa, Meraviglia, Viviana, de Araujo, Mariana E. G., Dokládal, Ladislav, Vilardo, Claudia, Monfregola, Jlenia, Zampelli, Nicolina, Vecchio Blanco, Francesca Del, Torella, Annalaura, Ruosi, Carolina, Fecarotta, Simona, Parenti, Giancarlo, Staiano, Leopoldo, Bellin, Milena, Huber, Lukas A., De Virgilio, Claudio, Trepiccione, Francesco, Nigro, Vincenzo, and Ballabio, Andrea

Published
2023
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5. Urinary epidermal growth factor/monocyte chemotactic peptide 1 ratio as non-invasive predictor of Mayo clinic imaging classes in autosomal dominant polycystic kidney disease

Author

Rocchetti, Maria Teresa, Pesce, Francesco, Matino, Silvia, Piscopo, Giovanni, di Bari, Ighli, Trepiccione, Francesco, Capolongo, Giovanna, Perniola, Maria Antonietta, Song, Xuewen, Khowaja, Saima, Haghighi, Amirreza, Peters, Dorien, Paolicelli, Simona, Pontrelli, Paola, Netti, Giuseppe Stefano, Ranieri, Elena, Capasso, Giovambattista, Moschetta, Marco, Pei, York, and Gesualdo, Loreto

Published
2022
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7. Drug toxicity in the proximal tubule: new models, methods and mechanisms

Author

Hall, Andrew M., Trepiccione, Francesco, and Unwin, Robert J.

Subjects
Drugs -- Health aspects, Kidney diseases -- Risk factors, Pediatric research, Health
Abstract

The proximal tubule (PT) reabsorbs most of the glomerular filtrate and plays an important role in the uptake, metabolism and excretion of xenobiotics. Some therapeutic drugs are harmful to the PT, and resulting nephrotoxicity is thought to be responsible for approximately 1 in 6 of cases of children hospitalized with acute kidney injury (AKI). Clinically, PT dysfunction leads to urinary wasting of important solutes normally reabsorbed by this nephron segment, leading to systemic complications such as bone demineralization and a clinical scenario known as the renal Fanconi syndrome (RFS). While PT defects can be diagnosed using a combination of blood and urine markers, including urinary excretion of low molecular weight proteins (LMWP), standardized definitions of what constitutes clinically significant toxicity are lacking, and identifying which patients will go on to develop progressive loss of kidney function remains a major challenge. In addition, much of our understanding of cellular mechanisms of drug toxicity is still limited, partly due to the constraints of available cell and animal models. However, advances in new and more sophisticated in vitro models of the PT, along with the application of high-content analytical methods that can provide readouts more relevant to the clinical manifestations of nephrotoxicity, are beginning to extend our knowledge. Such technical progress should help in discovering new biomarkers that can better detect nephrotoxicity earlier and predict its long-term consequences, and herald a new era of more personalized medicine., Author(s): Andrew M. Hall [sup.1] [sup.2] , Francesco Trepiccione [sup.3] [sup.4] , Robert J. Unwin [sup.5] Author Affiliations: (1) grid.7400.3, 0000 0004 1937 0650, Institute of Anatomy, University of Zurich, [...]

Published
2022
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8. Surgery or Comorbidities: What Is the Primum Movens of Kidney Dysfunction After Nephrectomy? A Multicenter Study in Living Donors and Cancer Patients.

Author

Trevisani, Francesco, Floris, Matteo, Trepiccione, Francesco, Rosiello, Giuseppe, Capasso, Giovambattista, Pani, Antonello, Maculan, Marco, Mascia, Giacomo, Silvestre, Cristina, Bettiga, Arianna, Cinque, Alessandra, Capitanio, Umberto, Larcher, Alessandro, Briganti, Alberto, Salonia, Andrea, Rigotti, Paolo, Montorsi, Francesco, Angioi, Andrea, and Furian, Lucrezia

Subjects
RENAL cancer, ACUTE kidney failure, CHRONIC kidney failure, GLOMERULAR filtration rate, AGE differences
Abstract

Background and Hypothesis: Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are significant risks for kidney cancer (KC) patients undergoing partial (PN) or radical nephrectomy (RN) and for living kidney donors (LKD). This study compares AKI and CKD incidence in these groups with a pre-operative glomerular filtration rate (GFR) over 60 mL/min/1.73 m2. Methods: This study included 465 KC patients with cT1-2N0M0 kidney mass and 256 LKD who underwent nephrectomy at four Italian institutions from 2014 to 2021. Data on demographics, comorbidities, and therapies were analyzed. Serum creatinine and estimated GFR (eGFR) were measured before and after surgery. Outcomes were AKI (per KDIGO guidelines) and CKD stage progression. Analyses included descriptive statistics, ANOVA, logistic regression, and Kaplan–Meier survival. Results: Among 721 patients, significant age and gender differences were noted. Hypertension (41%) and diabetes (7.1%) were prevalent in RN and PN groups. Post-surgery AKI was more common in donors (84%), while CKD stage progression varied by surgery type (CKD stage G3 after 60 months: RN 48.91%, PN 18.22%, LKD 26.56%). Age, pre-surgery CKD, and surgery type predicted CKD progression. Limitations include retrospective design and bias. Conclusions: Both LKD and KC patients face similar AKI and CKD risks. Surgery type significantly influences AKI and CKD incidence, highlighting the importance of approach. [ABSTRACT FROM AUTHOR]

Published
2024
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11. #2490 Analyzing the morphology of mesothelial cells when exposed to peritoneal dialysis solutions

Author

Masola, Valentina, primary, D'apolito, Luciano, additional, D'alessandro, Angelo, additional, Franchi, Marco, additional, Bonomini, Mario, additional, Capasso, Giovambattista, additional, Trepiccione, Francesco, additional, Onisto, Maurizio, additional, Prosdocimi, Tommaso, additional, Divino-Filho, Jose Carolino, additional, and Arduini, Arduino, additional

Published
2024
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15. Diagnosis and management of Bartter syndrome: executive summary of the consensus and recommendations from the European Rare Kidney Disease Reference Network Working Group for Tubular Disorders

Author

Konrad, Martin, Nijenhuis, Tom, Ariceta, Gema, Bertholet-Thomas, Aurelia, Calo, Lorenzo A., Capasso, Giovambattista, Emma, Francesco, Schlingmann, Karl P., Singh, Mandeep, Trepiccione, Francesco, Walsh, Stephen B., Whitton, Kirsty, Vargas-Poussou, Rosa, and Bockenhauer, Detlef

Published
2021
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19. Animal models to study cognitive impairment of chronic kidney disease.

Author

Silva, Pedro H. Imenez, Pepin, Marion, Figurek, Andreja, Gutiérrez-Jiménez, Eugenio, Bobot, Mickaël, Iervolino, Anna, Mattace-Raso, Francesco, Hoorn, Ewout J., Bailey, Matthew A., Hénaut, Lucie, Nielsen, Rikke, Frische, Sebastian, Trepiccione, Francesco, Hafez, Gaye, Altunkaynak, Hande O., Endlich, Nicole, Unwin, Robert, Capasso, Giovambattista, Pesic, Vesna, and Massy, Ziad

Subjects
CHRONIC kidney failure, COGNITION disorders, EXECUTIVE function, ACTIVITIES of daily living, COGNITION
Abstract

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives, and society. However, the underlying pathomechanisms are poorly understood, and current therapies mostly aim at supporting patients in their daily lives. This illustrates the urgent need to elucidate the pathogenesis and potential therapeutic targets and test novel therapies in appropriate preclinical models. Here, we will outline the necessary criteria for experimental modeling of cognitive disorders in CKD. We discuss the use of mice, rats, and zebrafish as model systems and present valuable techniques through which kidney function and cognitive impairment can be assessed in this setting. Our objective is to enable researchers to overcome hurdles and accelerate preclinical research aimed at improving the therapy of people with CKD and MCI. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Renal Function Outcomes at 5 Years from Radical and Partial Nephrectomies in Normal Renal Function Patients: An Insidious Tale of Failed Renal Hyperfiltrations: PUB321

Author

Trevisani, Francesco, Di marco, Federico, Floris, Matteo, Trepiccione, Francesco, Rosiello, Giuseppe, Pani, Antonello, Capasso, Giovambattista, Vitagliano, Caterina, Mascia, Giacomo, Fiorio, Francesco, Cinque, Alessandra, Bettiga, Arianna, Larcher, Alessandro, Capitanio, Umberto, Salonia, Andrea, and Montorsi, Francesco

Published
2021
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22. The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

Author

Trepiccione, Francesco, primary, Iervolino, Anna, additional, D’Acierno, Mariavittoria, additional, Siccardi, Sabrina, additional, Costanzo, Vincenzo, additional, Sardella, Donato, additional, De La Motte, Luigi R., additional, D’Apolito, Luciano, additional, Miele, Antonio, additional, Perna, Alessandra F., additional, Capolongo, Giovanna, additional, Zacchia, Miriam, additional, Frische, Sebastian, additional, Nielsen, Rikke, additional, Staiano, Leopoldo, additional, Sambri, Irene, additional, De Cegli, Rossella, additional, Unwin, Robert, additional, Eladari, Dominique, additional, and Capasso, Giovambattista, additional

Published
2023
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23. The human EV membranome

Author

Ramos Juarez, Ana Paulina, primary, Trepiccione, Francesco, additional, Capasso, Giovambattista, additional, and Pocsfalvi, Gabriella, additional

Published
2020
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25. Cyclosporin-induced hypertension is associated with the up-regulation of Na+-K+-2Cl− cotransporter (NKCC2)

Author

Capolongo, Giovanna, primary, Damiano, Sara, additional, Suzumoto, Yoko, additional, Zacchia, Miriam, additional, Rizzo, Maria, additional, Zona, Enrica, additional, Pollastro, Rosa Maria, additional, Simeoni, Mariadelina, additional, Ciarcia, Roberto, additional, Trepiccione, Francesco, additional, and Capasso, Giovambattista, additional

Published
2023
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26. Animal models to study cognitive impairment of chronic kidney disease

Author

Imenez Silva, Pedro H., Pepin, Marion, Figurek, Andreja, Gutiérrez-Jiménez, Eugenio, Bobot, Mickaël, Iervolino, Anna, Mattace-Raso, Francesco, Hoorn, Ewout J., Bailey, Matthew A., Hénaut, Lucie, Nielsen, Rikke, Frische, Sebastian, Trepiccione, Francesco, Hafez, Gaye, Altunkaynak, Hande O., Endlich, Nicole, Unwin, Robert, Capasso, Giovambattista, Pesic, Vesna, Massy, Ziad, and Wagner, Carsten A.

Published
2024
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30. Cyclosporin-induced hypertension is associated with the up-regulation of Na+-K+-2Cl− cotransporter (NKCC2).

Author

Capolongo, Giovanna, Damiano, Sara, Suzumoto, Yoko, Zacchia, Miriam, Rizzo, Maria, Zona, Enrica, Pollastro, Rosa Maria, Simeoni, Mariadelina, Ciarcia, Roberto, Trepiccione, Francesco, and Capasso, Giovambattista

Subjects
KIDNEY cortex, GLOMERULAR filtration rate, HYPERTENSION, SPRAGUE Dawley rats, KIDNEY tubules
Abstract

Background The use of cyclosporin A (CsA) is hampered by the development of nephrotoxicity including hypertension, which is partially dependent on renal sodium retention. To address this issue, we have investigated in vivo sodium reabsorption in different nephron segments of CsA-treated rats through micropuncture study coupled to expression analyses of sodium transporters. To translate the findings in rats to human, kidney-transplanted patients having CsA treatment were enrolled in the study. Methods Adult male Sprague–Dawley rats were treated with CsA (15 mg/kg/day) for 21 days, followed by micropuncture study and expression analyses of sodium transporters. CsA-treated kidney-transplanted patients with resistant hypertension were challenged with 50 mg furosemide. Results CsA-treated rats developed hypertension associated with reduced glomerular filtration rate. In vivo microperfusion study demonstrated a significant decrease in rate of absolute fluid reabsorption in the proximal tubule but enhanced sodium reabsorption in the thick ascending limb of Henle's loop (TAL). Expression analyses of sodium transporters at the same nephron segments further revealed a reduction in Na+-H+ exchanger isoform 3 (NHE3) in the renal cortex, while TAL-specific, furosemide-sensitive Na+-K+-2Cl− cotransporter (NKCC2) and NHE3 were significantly upregulated in the inner stripe of outer medulla. CsA-treated patients had a larger excretion of urinary NKCC2 protein at basal condition, and higher diuretic response to furosemide, showing increased FeNa+, FeCl− and FeCa2+ compared with both healthy controls and FK506-treated transplanted patients. Conclusion Altogether, these findings suggest that up-regulation of NKCC2 along the TAL facilitates sodium retention and contributes to the development of CsA-induced hypertension. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Contributors

Author

Albright, Robert C., primary, Amerling, Richard, additional, Angeli, Paolo, additional, Angelotti, Maria Lucia, additional, Antonelli, Massimo, additional, Antoniotti, Riccardo, additional, Arulkumaran, Nishkantha, additional, Asfar, Pierre, additional, Ash, Stephen R., additional, Aucella, Filippo, additional, Aucella, Francesco, additional, Ave, Samuele, additional, Bagshaw, Sean M., additional, Balaraman, Vasanthi, additional, Baldwin, Ian, additional, Bargman, Joanne M., additional, Barletta, Gina-Marie, additional, Barletta, Jeffrey F., additional, Barnela, Shriganesh R., additional, Bayır, Hülya, additional, Beaulieu, Monica, additional, Bellasi, Antonio, additional, Bellomo, Rinaldo, additional, Beloncle, François, additional, Bhansali, Arjun, additional, Bihorac, Azra, additional, Billings, Frederic T., additional, Birk, Horst-Walter, additional, Bonilla-Reséndiz, Luis Ignacio, additional, Bouchard, Josée, additional, Bourke, Edmund, additional, Braitberg, George, additional, Brendolan, Alessandra, additional, Brocca, Alessandra, additional, Brophy, Patrick D., additional, Bucala, Richard, additional, Bunchman, Timothy E., additional, Burdmann, Emmanuel A., additional, Busse, Laurence W., additional, Caires, Renato Antunes, additional, Caironi, Pietro, additional, Camilla, Roberta, additional, Campos, Israel, additional, Canaud, Bernard, additional, Cantaluppi, Vincenzo, additional, Martinez, Maria P., additional, Capasso, Giovambattista, additional, Carcillo, Joseph A., additional, Carlesso, Eleonora, additional, Casino, Francesco G., additional, Castellano, Giuseppe, additional, Catania, Matteo, additional, Cawcutt, Kelly A., additional, Cerda, Jorge, additional, Charen, Elliot, additional, Chawla, Lakhmir S., additional, Chiaramonte, Stefano, additional, Chua, Horng-Ruey, additional, Cianciaruso, Bruno, additional, Ciceri, Paola, additional, Cieslak, Jacek, additional, Clark, William R., additional, Claure-Del Granado, Rolando, additional, Clementi, Anna, additional, Co, Ivan N., additional, Coelho, Fernanda Oliveira, additional, Conte, Ferruccio, additional, Corey, Howard E., additional, Cosmai, Laura, additional, Costalonga, Elerson Carlos, additional, Costamagna, Andrea, additional, Costanzo, Maria Rosa, additional, Cozzolino, Mario, additional, Cramer, Carl H., additional, Cravedi, Paolo, additional, Crepaldi, Carlo, additional, Creteur, Jacques, additional, Crew, R. John, additional, da Costa e Silva, Verônica Torres, additional, Davenport, Andrew, additional, Davies, Andrew R., additional, D'Costa, Rohit, additional, Dean, Dawson F., additional, Debiais, Charlotte, additional, de Cal, Massimo, additional, Dedhia, Paras, additional, de Grooth, Harm-Jan, additional, Dell'Aquila, Roberto, additional, Dellepiane, Sergio, additional, Dellinger, Richard Phillip, additional, Del Vecchio, Lucia, additional, Depner, Thomas A., additional, De Rosa, Silvia, additional, Deutschman, Clifford S., additional, Devarajan, Prasad, additional, Dewitte, A., additional, Di Iorio, Biagio R., additional, Di Lullo, Luca, additional, Di Micco, Lucia, additional, Di Nardo, Matteo, additional, Ding, Xiaoqiang, additional, D'Ippoliti, Fiorella, additional, Di Somma, Salvatore, additional, Doi, Kent, additional, Dries, David J., additional, Druml, Wilfred, additional, Duke, Graeme, additional, Durand, Francois, additional, Eadon, Michael T., additional, Eckstein, Devin, additional, Egi, Moritoki, additional, Eiam-Ong, Somchai, additional, Elbers, Paul W.G., additional, Elli, Francesca, additional, Elliott, Steve, additional, Emlet, David R., additional, Endre, Zoltan, additional, Evans, Roger G., additional, Fanelli, Vito, additional, Fattahi, Fatemeh, additional, Federspiel, Christine Kinggaard, additional, Ferrada, Marcela A., additional, Ferrari, Fiorenza, additional, Fiaccadori, Enrico, additional, Fiorentino, Marco, additional, Fisher, Caleb, additional, Flessner, Michael F., additional, Formica, Marco, additional, Forni, Lui G., additional, Francoz, Claire, additional, French, Craig, additional, Fuhrman, Dana Y., additional, Fumagalli, Giordano, additional, Galbusera, Miriam, additional, Gallieni, Maurizio, additional, Gammill, Hilary S., additional, Gao, Dayong, additional, Garzotto, Francesco, additional, Gatta, Giuseppe, additional, Genga, Kelly R., additional, Genovesi, Simonetta, additional, Genyk, Yuri S., additional, Geradin, Christel, additional, Gesualdo, Loreto, additional, Giavarina, Davide, additional, Giuliani, Anna, additional, Glezerman, Ilya G., additional, Goldstein, Stuart L., additional, Golper, Thomas A., additional, Gómez, Hernando, additional, Granata, Antonio, additional, Grandaliano, Giuseppe, additional, Grasselli, Giacomo, additional, Groeneveld, A.B. Johan, additional, Guerci, Philippe, additional, Gunnerson, Kyle J., additional, Harbord, Nikolas, additional, Harshman, Lyndsay A., additional, Hennessy, Anthony J., additional, Hill, Graham L., additional, Hobson, Charles, additional, Hohenstein, Bernd, additional, Honoré, Patrick M., additional, Horwitz, Edward, additional, Hosseinian, Leila, additional, Hoste, Eric A.J., additional, House, Andrew A., additional, Humes, H. David, additional, Husain-Syed, Faeq, additional, Ince, Can, additional, Ing, Todd S., additional, Jacobs, Rita, additional, Jaswal, Dharmvir, additional, Jeyabalan, Arun, additional, Joannes-Boyau, Olivier, additional, Joannidis, Michael, additional, Joyce, Emily, additional, Kane-Gill, Sandra L., additional, Kaplan, Lewis J., additional, Kashani, Kianoush, additional, Katz, Nevin, additional, Kellum, John A., additional, Khanna, Ramesh, additional, Kim-Campbell, Nahmah, additional, King, Joshua D., additional, Kirwan, Christopher J., additional, Kiss, Joseph E., additional, Klein, David, additional, Kotanko, Peter, additional, Krediet, Raymond T., additional, Kuhlmann, Martin K., additional, Kuiper, Jan Willem, additional, Lachance, Philippe, additional, Lameire, Norbert, additional, Langer, Thomas, additional, Lankadeva, Yugeesh R., additional, Laurin, Louis-Philippe, additional, Lazzeri, Elena, additional, Leblanc, Martine, additional, Lefebvre, Joannie, additional, Lentini, Paolo, additional, Leray-Moragués, Hélène, additional, Levin, Adeera, additional, Lew, Susie Q., additional, Liapis, Helen, additional, Liu, Kathleen D., additional, Livigni, Sergio, additional, Locatelli, Francesco, additional, Lorenzin, Anna, additional, Lu, Jian-Da, additional, Lu, Renhua, additional, Lysak, Nicholas, additional, Macedo, Etienne, additional, Madan, Niti, additional, Madore, François, additional, Maerz, Linda L., additional, Maiden, Matthew J., additional, Malhotra, Rakesh, additional, Marengo, Marita, additional, Mariano, Filippo, additional, Marik, Paul E., additional, Marini, John J., additional, Marino, Rossella, additional, Marshall, Mark R., additional, Mårtensson, Johan, additional, Matsuura, Ryo, additional, May, Clive N., additional, Mazzone, Patrizio, additional, McCauley, Jerry, additional, McCullough, Peter A., additional, McMahon, Blaithin A., additional, Mehta, Ravindra L., additional, Mele, Caterina, additional, Menon, Madhav, additional, Meola, Mario, additional, Mérouani, Aicha, additional, Meuwly, Jean-Yves, additional, Milla, Paola, additional, Misra, Madhukar, additional, Misra, Paraish S., additional, Mizock, Barry A., additional, Modi, Jwalant R., additional, Moeckel, Gilbert, additional, Molitoris, Bruce A., additional, Morabito, Santo, additional, Mucelli, Roberto Pozzi, additional, Murray, Patrick T., additional, Murugan, Raghavan, additional, Nadim, Mitra K., additional, Nair, Devika, additional, Nalesso, Federico, additional, Neri, Mauro, additional, Nguyen, Trung C., additional, Ni, Zhaohui, additional, Noris, Marina, additional, Novick, Tessa, additional, O'Horo, John C., additional, Okusa, Mark Douglas, additional, Opal, Steven M., additional, Opdam, Helen Ingrid, additional, Ostermann, Marlies, additional, Ottaviano, Emerenziana, additional, Oudemans-van Straaten, Heleen M., additional, Overgaard-Steensen, Christian, additional, Padalino, Massimo A., additional, Panichi, Vincenzo, additional, Parameswaran, Priyanka, additional, Patel, Samir S., additional, Payen, Didier, additional, Pea, Federico, additional, Peacock, W. Frank, additional, Peart, Sandrica Young, additional, Peerapornratana, Sadudee, additional, Pelosi, Paolo, additional, Peng, Zhi-Yong, additional, Perico, Norberto, additional, Peruzzi, Licia, additional, Pesce, Francesco, additional, Pesenti, Antonio, additional, Petrucci, Ilaria, additional, Pham, Phuong-Chi, additional, Pham, Phuong-Thu, additional, Phoon, Richard K.S., additional, Piano, Salvatore, additional, Pinsky, Michael R., additional, Piquilloud, Lise, additional, Pistolesi, Valentina, additional, Plank, Lindsay D., additional, Plötz, Frans B., additional, Podestá, Manuel Alfredo, additional, Porta, Camillo, additional, Pozzato, Marco, additional, Prencipe, Michele, additional, Prowle, John R., additional, Puthucheary, Zudin A., additional, Qu, Lirong, additional, Rachoin, Jean-Sebastien, additional, Radhakrishnan, Jai, additional, Ranieri, V. Marco, additional, Ratanarat, Ranistha, additional, Remuzzi, Giuseppe, additional, Resnick, Shelby, additional, Rewa, Oleksa G., additional, Ricci, Zaccaria, additional, Ridel, Christophe, additional, Rifai, Kinan, additional, Ring, Troels, additional, Rizo-Topete, Lilia M., additional, Roessler, Eric, additional, Romagnani, Paola, additional, Romagnoli, Stefano, additional, Ronco, Claudio, additional, Ronco, Federico, additional, Rosner, Mitchell H., additional, Rossetti, Emanuele, additional, Russell, James A., additional, Saab, Georges, additional, Sabatino, Alice, additional, Saboo, Sonali S., additional, Samoni, Sara, additional, Sappington, Penny Lynn, additional, Sartori, Marco, additional, Savige, Judy, additional, Schena, Francesco Paolo, additional, Schneider, Antoine Guillaume, additional, Schraverus, Pieter, additional, Schulte, Wibke, additional, Segoloni, Giuseppe, additional, Semler, Matthew W., additional, Sharma, Aashish, additional, Shaw, Andrew, additional, Sheth, Naitik, additional, Shukla, Ashutosh, additional, Siddall, Eric C., additional, Sievers, Theodore M., additional, Siew, Edward D., additional, Singbartl, Kai, additional, Singer, Mervyn, additional, Singh, Pooja, additional, Smith, Loren E., additional, Soni, Sachin S., additional, Soto, Mara Serrano, additional, Spapen, Herbert D., additional, Srisawat, Nattachai, additional, Srivastava, Ajay, additional, Stellin, Giovanni, additional, Symons, Jordan M., additional, Szamosfalvi, Balazs, additional, Tai, Kian Bun, additional, Takalkar, Unmesh V., additional, Teitelbaum, Isaac, additional, Tetta, Ciro, additional, Thakar, Charuhas V., additional, Tonon, Marta, additional, Trepiccione, Francesco, additional, Triulzi, Darrell, additional, Tushar, Chopra, additional, Uchino, Shigehiko, additional, Valika, Ali, additional, Van Biesen, Wim, additional, Vandenberghe, Wim, additional, Vanholder, Raymond, additional, Vanmassenhove, Jill, additional, Verbine, Anton, additional, Vergano, Marco, additional, Villa, Gianluca, additional, Villeneuve, Pierre-Marc, additional, Vincent, Jean-Louis, additional, Vinsonneau, Christophe, additional, Virzì, Grazia Maria, additional, Visconti, Federico, additional, Visvanathan, Ravindran, additional, Van Vong, Li, additional, Walmrath, Hans-Dieter, additional, Ward, Peter A., additional, Weir, Matthew A., additional, Wen, Xiaoyan, additional, Wendon, Julia, additional, Winchester, James Frank, additional, Wong, Adrian, additional, Woodhouse, Elke L., additional, Xue, Jun, additional, Yadav, Anju, additional, Yerram, Preethi, additional, Yessayan, Lenar, additional, Yeun, Jane Y., additional, Yu, Alex W., additional, Zaccaria, Marta, additional, Zacchia, Miriam, additional, Zachariah, Teena P., additional, Zamperetti, Nereo, additional, Zampieri, Fernando G., additional, Zanco, Pierluigi, additional, Zanella, Alberto, additional, Zanoli, Luca, additional, Zappitelli, Michael, additional, Zaragoza, Jose J., additional, Zarbock, Alexander, additional, Zaroccolo, Marta, additional, Zhang, Han, additional, and Zimmer, Andrea, additional

Published
2019
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33. Lanthionine and Other Relevant Sulfur Amino Acid Metabolites: Detection of Prospective Uremic Toxins in Serum by Multiple Reaction Monitoring Tandem Mass Spectrometry

Author

Perna, Alessandra F., primary, Pane, Francesca, additional, Sepe, Nunzio, additional, Fontanarosa, Carolina, additional, Pinto, Gabriella, additional, Zacchia, Miriam, additional, Trepiccione, Francesco, additional, Anishchenko, Evgeniya, additional, Ingrosso, Diego, additional, Pucci, Piero, additional, and Amoresano, Angela, additional

Published
2019
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34. Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?

Author

Bikbov B., Soler M. J., Pesic V., Capasso G., Unwin R., Endres M., Remuzzi G., Perico N., Gansevoort R., Mattace-Raso F., Bruchfeld A., Figurek A., Hafez G., Trepiccione Francesco, CONNECT Action, Bikbov, B., Soler, M. J., Pesic, V., Capasso, G., Unwin, R., Endres, M., Remuzzi, G., Perico, N., Gansevoort, R., Mattace-Raso, F., Bruchfeld, A., Figurek, A., Hafez, G., Trepiccione, Francesco, Connect, Action, Internal Medicine, and University of Zurich

Subjects
medicine.medical_specialty, 10017 Institute of Anatomy, Renal function, 610 Medicine & health, Review, 030204 cardiovascular system & hematology, albuminuria, 03 medical and health sciences, 0302 clinical medicine, mild cognitive impairment, Risk Factors, mental disorders, medicine, Dementia, Albuminuria, Humans, Cognitive Dysfunction, Endothelial dysfunction, Risk factor, Cognitive decline, AcademicSubjects/MED00340, Intensive care medicine, Cross-Sectional Studie, Transplantation, glomerular filtration rate, business.industry, Risk Factor, medicine.disease, 3. Good health, Cross-Sectional Studies, Nephrology, Relative risk, Disease Progression, 570 Life sciences, biology, medicine.symptom, business, 030217 neurology & neurosurgery, chronic kidney disease, dementia, Kidney disease, Human
Abstract

Kidney dysfunction can profoundly influence many organ systems, and recent evidence suggests a potential role for increased albuminuria in the development of mild cognitive impairment (MCI) or dementia. Epidemiological studies conducted in different populations have demonstrated that the presence of increased albuminuria is associated with a higher relative risk of MCI or dementia both in cross-sectional analyses and in studies with long-term follow-up. The underlying pathophysiological mechanisms of albuminuria’s effect are as yet insufficiently studied, with several important knowledge gaps still present in a complex relationship with other MCI and dementia risk factors. Both the kidney and the brain have microvascular similarities that make them sensitive to endothelial dysfunction involving different mechanisms, including oxidative stress and inflammation. The exact substrate of MCI and dementia is still under investigation, however available experimental data indicate that elevated albuminuria and low glomerular filtration rate are associated with significant neuroanatomical declines in hippocampal function and grey matter volume. Thus, albuminuria may be critical in the development of cognitive impairment and its progression to dementia. In this review, we summarize the available evidence on albuminuria’s link to MCI and dementia, point to existing gaps in our knowledge and suggest actions to overcome them. The major question of whether interventions that target increased albuminuria could prevent cognitive decline remains unanswered. Our recommendations for future research are aimed at helping to plan clinical trials and to solve the complex conundrum outlined in this review, with the ultimate goal of improving the lives of patients with chronic kidney disease., Graphical Abstract Graphical Abstract

Published
2022
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35. Protein Biocargo and Anti-Inflammatory Effect of Tomato Fruit-Derived Nanovesicles Separated by Density Gradient Ultracentrifugation and Loaded with Curcumin

Author

Mammadova Ramila, Maggio Serena, Fiume Immacolata, Bokka Ramesh, Moubarak Maneea, Gabriella Gellén, Gitta Schlosser, Adamo Giorgia, Bongiovanni Antonella, Trepiccione Francesco, Guescini Michele, Pocsfalvi Gabriella, Mammadova, Ramila, Maggio, Serena, Fiume, Immacolata, Bokka, Ramesh, Moubarak, Maneea, Gellén, Gabriella, Schlosser, Gitta, Adamo, Giorgia, Bongiovanni, Antonella, Trepiccione, Francesco, Guescini, Michele, and Pocsfalvi, Gabriella

Subjects
plant-derived nanovesicles (PDNVs), Pharmaceutical Science, in vitro analysis, loading method, tomato, in vitro analysi, protein functional analysis, proteomics, loading methods, curcumin, protein functional analysi, anti-inflammatory activity, proteomic
Abstract

Plant-derived nanovesicles (PDNVs) have become attractive alternatives to mammalian cell-derived extracellular vesicles (EVs) both as therapeutic approaches and drug-delivery vehicles. In this study, we isolated tomato fruit-derived NVs and separated them by the iodixanol density gradient ultracentrifugation (DGUC) into twelve fractions. Three visible bands were observed at densities 1.064 ± 0.007 g/mL, 1.103 ± 0.006 g/mL and 1.122 ± 0.012 g/mL. Crude tomato PDNVs and DGUC fractions were characterized by particle size-distribution, concentration, lipid and protein contents as well as protein composition using mass spectrometry-based proteomics. Cytotoxicity and anti-inflammatory activity of the DGUC fractions associated to these bands were assessed in the lipopolysaccharide (LPS)-stimulated human monocytic THP-1 cell culture. The middle and the low-density visible DGUC fractions of tomato PDNVs showed a significant reduction in LPS-induced inflammatory IL-1β cytokine mRNA production. Functional analysis of proteins identified in these fractions reveals the presence of 14-3-3 proteins, endoplasmic reticulum luminal binding proteins and GTP binding proteins associated to gene ontology (GO) term GO:0050794 and the regulation of several cellular processes including inflammation. The most abundant middle-density DGUC fraction was loaded with curcumin using direct loading, sonication and extrusion methods and anti-inflammatory activity was compared. The highest entrapment efficiency and drug loading capacity was obtained by direct loading. Curcumin loaded by sonication increased the basal anti-inflammatory activity of tomato PDNVs.

Published
2023
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39. Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study

Author

Verploegen, Maartje F A, Vargas-Poussou, Rosa, Walsh, Stephen B, Alpay, Harika, Amouzegar, Atefeh, Ariceta Iraola, Gema, Atmis, Bahriye, Bacchetta, Justine, Bárány, Peter, Baron, Stéphanie, Bayrakci, Umut Selda, Belge, Hendrica, Besouw, Martine, Blanchard, Anne, Bökenkamp, Arend, Boyer, Olivia, Burgmaier, Kathrin, Calò, Lorenzo A, Decramer, Stéphane, Devuyst, Olivier, van Dyck, Maria, Ferraro, Pietro Manuel, Fila, Marc, Francisco, Telma, Ghiggeri, Gian Marco, Gondra, Leire, Guarino, Stefano, Hooman, Nakysa, Hoorn, Ewout J, Houillier, Pascal, Kamperis, Konstantinos, Kari, Jameela A, Konrad, Martin, Levtchenko, Elena, Lucchetti, Laura, Lugani, Francesca, Marzuillo, Pierluigi, Mohidin, Barian, Neuhaus, Thomas J, Osman, Abdaldafae, Papizh, Svetlana, Perelló, Manel, Rookmaaker, Maarten B, Conti, Valerie Said, Santos, Fernando, Sawaf, Ghalia, Serdaroglu, Erkin, Szczepanska, Maria, Taroni, Francesca, Topaloglu, Rezan, Trepiccione, Francesco, Vidal, Enrico, Wan, Elizabeth R, Weber, Lutz, Yildirim, Zeynep Yuruk, Yüksel, Selçuk, Zlatanova, Galia, Bockenhauer, Detlef, Emma, Francesco, Nijenhuis, Tom, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Verploegen MFA] Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands. [Vargas-Poussou R] Department of Genetics, Centre de Références MARHEA, Hôpital Européen Georges Pompidou Assistance Publique Hôpitaux de Paris, Paris, France. [Walsh SB] Department of Renal Medicine, University College London, London, UK. [Alpay H] Division of Paediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey. [Amouzegar A] Division of Nephrology, Department of Medicine, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran. [Ariceta G] Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Perelló M] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Verploegen M. F. A., Vargas-Poussou R., Walsh S. B., ALPAY H., Amouzegar A., Ariceta G., ATMIŞ B., Bacchetta J., Barany P., Baron S., et al., Verploegen, Maartje F A, Vargas-Poussou, Rosa, Walsh, Stephen B, Alpay, Harika, Amouzegar, Atefeh, Ariceta, Gema, Atmis, Bahriye, Bacchetta, Justine, Bárány, Peter, Baron, Stéphanie, Bayrakci, Umut Selda, Belge, Hendrica, Besouw, Martine, Blanchard, Anne, Bökenkamp, Arend, Boyer, Olivia, Burgmaier, Kathrin, Calò, Lorenzo A, Decramer, Stéphane, Devuyst, Olivier, van Dyck, Maria, Ferraro, Pietro Manuel, Fila, Marc, Francisco, Telma, Ghiggeri, Gian Marco, Gondra, Leire, Guarino, Stefano, Hooman, Nakysa, Hoorn, Ewout J, Houillier, Pascal, Kamperis, Konstantino, Kari, Jameela A, Konrad, Martin, Levtchenko, Elena, Lucchetti, Laura, Lugani, Francesca, Marzuillo, Pierluigi, Mohidin, Barian, Neuhaus, Thomas J, Osman, Abdaldafae, Papizh, Svetlana, Perelló, Manel, Rookmaaker, Maarten B, Conti, Valerie Said, Santos, Fernando, Sawaf, Ghalia, Serdaroglu, Erkin, Szczepanska, Maria, Taroni, Francesca, Topaloglu, Rezan, Trepiccione, Francesco, Vidal, Enrico, Wan, Elizabeth R, Weber, Lutz, Yildirim, Zeynep Yuruk, Yüksel, Selçuk, Zlatanova, Galia, Bockenhauer, Detlef, Emma, Francesco, Nijenhuis, Tom, and UCL - SSS/IREC/NEFR - Pôle de Néphrologie

Subjects
Internal Diseases, Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Parathyroid Hormone [CHEMICALS AND DRUGS], Homeòstasi, urologic and male genital diseases, Sağlık Bilimleri, İç Hastalıkları, Clinical Medicine (MED), Bartter syndomr, Transplantasyon, Gitelman Syndrome/complications, salt losing tubulopathies, Homeostasis, HYPERCALCIURIA, Klinik Tıp (MED), Child, enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::defectos congénitos del transporte tubular renal::síndrome de Gitelman [ENFERMEDADES], Klinik Tıp, Hyperparathyroidism, Tıp, Nefroloji, fenómenos fisiológicos::homeostasis [FENÓMENOS Y PROCESOS], Nephrology, Üroloji, Medicine, Gitelman syndrome, Ronyons - Malalties - Malformacions, Urology, CALCIUM, Phosphates, UROLOGY & NEPHROLOGY, Health Sciences, Humans, parathyroid hormone, HYPERPARATHYROIDISM, ÜROLOJİ VE NEFROLOJİ, hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas peptídicas::hormona paratiroidea [COMPUESTOS QUÍMICOS Y DROGAS], phosphate, Transplantation, Internal Medicine Sciences, Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Tubular Transport, Inborn Errors::Bartter Syndrome [DISEASES], Dahili Tıp Bilimleri, Hormones peptídiques, CLINICAL MEDICINE, GENE, Bartter syndrome, Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Tubular Transport, Inborn Errors::Gitelman Syndrome [DISEASES], Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Cross-Sectional Studies, Calcium, Bartter Syndrome/complications, Physiological Phenomena::Homeostasis [PHENOMENA AND PROCESSES], enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::defectos congénitos del transporte tubular renal::síndrome de Bartter [ENFERMEDADES]
Abstract

European Reference Network for Rare Kidney Diseases (ERKNet) - European Union; Dutch Kidney Foundation [19OI06], Verploegen MFA, Vargas-Poussou R, Walsh SB, Alpay H, Amouzegar A, Ariceta G, Atmis B, Bacchetta J, Bárány P, Baron S, Bayrakci US, Belge H, Besouw M, Blanchard A, Bökenkamp A, Boyer O, Burgmaier K, Calò LA, Decramer S, Devuyst O, van Dyck M, Ferraro PM, Fila M, Francisco T, Ghiggeri GM, Gondra L, Guarino S, Hooman N, Hoorn EJ, Houillier P, Kamperis K, Kari JA, Konrad M, Levtchenko E, Lucchetti L, Lugani F, Marzuillo P, Mohidin B, Neuhaus TJ, Osman A, Papizh S, Perelló M, Rookmaaker MB, Conti VS, Santos F, Sawaf G, Serdaroglu E, Szczepanska M, Taroni F, Topaloglu R, Trepiccione F, Vidal E, Wan ER, Weber L, Yildirim ZY, Yüksel S, Zlatanova G, Bockenhauer D, Emma F, Nijenhuis T

Published
2022
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40. The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo.

Author

Engbjerg, Jacob Schade, Costanzo, Vincenzo, Sardella, Donato, Bordoni, Luca, Jakobsen, Steen, D'Apolito, Luciano, Frøkiær, Jørgen, Trepiccione, Francesco, Capasso, Giovambattista, Frische, Sebastian, and Akers, Walter

Subjects
POSITRON emission tomography, PROXIMAL kidney tubules, FLUORESCENCE, ALBUMINS, BIOLOGICAL transport, SECRETION, SERUM albumin
Abstract

Accumulation of uremic toxins may lead to the life-threatening condition "uremic syndrome" in patients with advanced chronic kidney disease (CKD) requiring renal replacement therapy. Clinical evaluation of proximal tubular secretion of organic cations (OC), of which some are uremic toxins, is desired, but difficult. The biomedical knowledge on OC secretion and cellular transport partly relies on studies using the fluorescent tracer 4-dimethylaminostyryl)- N -methylpyridinium (ASP+), which has been used in many studies of renal excretion mechanisms of organic ions and which could be a candidate as a PET tracer. This study is aimed at expanding the knowledge of the tracer characteristics of ASP+ by recording the distribution and intensity of ASP+ signals in vivo both by fluorescence and by positron emission tomography (PET) imaging and at investigating if the fluorescence signal of ASP+ is influenced by the presence of albumin. Two-photon in vivo microscopy of male Münich Wistar Frömter rats showed that a bolus injection of ASP+ conferred a fluorescence signal to the blood plasma lasting for about 30 minutes. In the renal proximal tubule, the bolus resulted in a complex pattern of fluorescence including a rapid and strong transient signal at the brush border, a very low signal in the luminal fluid, and a slow transient intracellular signal. PET imaging using 11C-labelled ASP+ showed accumulation in the liver, heart, and kidney. Fluorescence emission spectra recorded in vitro of ASP+ alone and in the presence of albumin using both 1-photon excitation and two-photon excitation showed that albumin strongly enhance the emission from ASP+ and induce a shift of the emission maximum from 600 to 570 nm. Conclusion. The renal pattern of fluorescence observed from ASP+ in vivo is likely affected by the local concentration of albumin, and quantification of ASP+ fluorescent signals in vivo cannot be directly translated to ASP+ concentrations. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Treatment and long-term outcome in primary nephrogenic diabetes insipidus.

Author

Lopez-Garcia, Sergio C, Downie, Mallory L, Kim, Ji Soo, Boyer, Olivia, Walsh, Stephen B, Nijenhuis, Tom, Papizh, Svetlana, Yadav, Pallavi, Reynolds, Ben C, Decramer, Stéphane, Besouw, Martine, Carrascosa, Manel Perelló, Scola, Claudio La, Trepiccione, Francesco, Ariceta, Gema, Hummel, Aurélie, Dossier, Claire, Sayer, John A, Konrad, Martin, and Keijzer-Veen, Mandy G

Subjects
MENTAL illness, DIABETES insipidus, ATTENTION-deficit hyperactivity disorder, CHRONIC kidney failure, FULL-time employment, BODY mass index
Abstract

Background Primary nephrogenic diabetes insipidus (NDI) is a rare disorder and little is known about treatment practices and long-term outcome. Methods Paediatric and adult nephrologists contacted through European professional organizations entered data in an online form. Results Data were collected on 315 patients (22 countries, male 84%, adults 35%). Mutation testing had been performed in 270 (86%); pathogenic variants were identified in 258 (96%). The median (range) age at diagnosis was 0.6 (0.0–60) years and at last follow-up 14.0 (0.1–70) years. In adults, height was normal with a mean (standard deviation) score of −0.39 (±1.0), yet there was increased prevalence of obesity (body mass index >30 kg/m2; 41% versus 16% European average; P < 0.001). There was also increased prevalence of chronic kidney disease (CKD) Stage ≥2 in children (32%) and adults (48%). Evidence of flow uropathy was present in 38%. A higher proportion of children than adults (85% versus 54%; P < 0.001) received medications to reduce urine output. Patients ≥25 years were less likely to have a university degree than the European average (21% versus 35%; P = 0.003) but full-time employment was similar. Mental health problems, predominantly attention-deficit hyperactivity disorder (16%), were reported in 36% of patients. Conclusion This large NDI cohort shows an overall favourable outcome with normal adult height and only mild to moderate CKD in most. Yet, while full-time employment was similar to the European average, educational achievement was lower, and more than half had urological and/or mental health problems. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Next-Generation Sequencing (NGS) Analysis Illustrates the Phenotypic Variability of Collagen Type IV Nephropathies

Author

Zacchia, Miriam, primary, Capolongo, Giovanna, additional, Del Vecchio Blanco, Francesca, additional, Secondulfo, Floriana, additional, Gupta, Neha, additional, Blasio, Giancarlo, additional, Pollastro, Rosa Maria, additional, Cervesato, Angela, additional, Piluso, Giulio, additional, Gigliotti, Giuseppe, additional, Torella, Annalaura, additional, Nigro, Vincenzo, additional, Perna, Alessandra F., additional, Capasso, Giovambattista, additional, and Trepiccione, Francesco, additional

Published
2023
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46. Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?

Author

Liabeuf, Sophie, Pepin, Marion, Franssen, Casper, Viggiano, Davide, Carriazo, Sol, Gansevoort, Ron, Gesualdo, Loreto, Hafez, Gaye, Malyszko, Jolanta, Mayer, Christopher, Nitsch, Dorothea, Ortiz, Alberto, Pešić, Vesna, Wiecek, Andrzej, Massy, Ziad, Capasso, Giovambattista, Andrade, Alexandre, Bachmann, Maie, Bumblyte, Inga, Covic, Adrian Constantin, Delgado, Pilar, Endlich, Nicole, Engvig, Andreas, Fouque, Denis, Frische, Sebastian, Garneata, Liliana, Giannakou, Konstantinos, Goumenos, Dimitrios, Kartal, Ayşe Tuğba, Mani, Laila-Yasmin, Marti, Hans-Peter, Nielsen, Rikke, Rroji, Merita, Sakkas, Giorgos, Spasovski, Goce, Stevens, Kate, Vazelov, Evgueniy, Zacharia, Lefteris, Ferreira, Ana Carina, Hoorn, Ewout, Figurek, Andreja, Unwin, Robert, Wagner, Carsten, Wanner, Christoph, BRUCHFELD, Annette, Fridolin, Ivo, Romeo, Maria José Soler, Barbieri, Michelangela, Batinić, Bojan, Carrasco, Laura, Martino, Gianvito, Raso, Francesco Mattace, Nistor, Ionut, Paolisso, Giuseppe, Rastenytė, Daiva, Stefan, Gabriel, Tedeschi, Gioacchino, Bikbov, Boris, Endlich, Karl Hans, Godefroy, Olivier, Chillon, Jean-Marc, Kossioni, Anastassia, Kurganaite, Justina, Perico, Norberto, Remuzzi, Giuseppe, Grodzicki, Tomasz, Trepiccione, Francesco, Zoccali, Carmine, Arici, Mustafa, Blankestijn, Peter, Eckardt, Kai-Uwe, Fliser, Danilo, Jiménez, Eugenio Gutiérrez, Konig, Maximilian, Rychlik, Ivan, Deleidi, Michela, REUSZ, George, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Hôpital Ambroise Paré [AP-HP], Groningen University Medical Centre, Department of Nephrology [Groningue, Pays-Bas], University Medical Center Groningen [Groningen] (UMCG), CeRTA, Liabeuf, S., Pepin, M., Franssen, C. F. M., Viggiano, D., Carriazo, S., Gansevoort, R. T., Gesualdo, L., Hafez, G., Malyszko, J., Mayer, C., Nitsch, D., Ortiz, A., Pesic, V., Wiecek, A., and Massy, Z. A.

Subjects
medicine.medical_specialty, CLINICAL-OUTCOMES, HEMODIALYSIS, Movement disorders, 030232 urology & nephrology, RENAL DYSFUNCTION, URIC-ACID, Review, 03 medical and health sciences, 0302 clinical medicine, PARKINSONS-DISEASE, Diabetes mellitus, Internal medicine, Epidemiology, medicine, CKD, INDOXYL SULFATE, AcademicSubjects/MED00340, Stroke, Depression (differential diagnoses), RISK, Transplantation, Kidney, COMPLICATIONS, business.industry, cardiovascular, medicine.disease, COGNITIVE FUNCTION, indoxyl sulphate, stroke, 3. Good health, medicine.anatomical_structure, Clinical research, Nephrology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, business, 030217 neurology & neurosurgery, Kidney disease, uraemic toxins
Abstract

Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that uraemic toxins, for example indoxyl sulphate, have a neurotoxic effect. A better understanding of factors responsible for the elevated prevalence of neurological disorders among patients with CKD might facilitate the development of novel treatments. Here, we review (i) the potential clinical impact of CKD on cerebrovascular and neurological complications, (ii) the mechanisms underlying the uraemic toxins’ putative action (based on pre-clinical and clinical research) and (iii) the potential impact of these findings on patient care., Graphical Abstract Graphical Abstract

Published
2021
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47. NON-STEROIDAL ANTI-INFLAMMATORY DRUGS TREATMENT AND RISK OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH BARTTER SYNDROME AND PRIMARY NEPHROGENIC DIABETES INSIPIDUS

Author

Ariceta, Gema, Arbeiter, Klaus, Marlais, Matko, De Zan, Francesca, Becherucci, Francesca, Besouw, Martine, Burgmaier, Kathrin, Morin, Denis, Dolezel, Zdenek, DURSUN, İSMAİL, Espinosa, Laura, Gjerstad, Ann Christin, Gondra, Leire, Harmer, Matthew, Konrad, Martin, Lemoine, Sandrine, Madariaga, Leire, Marzuillo, Pierluigi, Meneghesso, Davide, Papizh, Svetlana, Printza, Nikoleta, Schlingmann, Karl, Trepiccione, Francesco, Tse, Yincent, Tsygin, Alexey, Wasilewska, Anna, Weitz, Marcus, Zieg, Jakub, Emma, Francesco, and Bockenhauer, Detlef

Published
2022

49. Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b

Author

D’Acierno, Mariavittoria, primary, Resaz, Roberta, additional, Iervolino, Anna, additional, Nielsen, Rikke, additional, Sardella, Donato, additional, Siccardi, Sabrina, additional, Costanzo, Vincenzo, additional, D’Apolito, Luciano, additional, Suzumoto, Yoko, additional, Segalerba, Daniela, additional, Astigiano, Simonetta, additional, Perna, Alessandra F., additional, Capasso, Giovambattista, additional, Eva, Alessandra, additional, and Trepiccione, Francesco, additional

Published
2022
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50. Atorvastatin in the treatment of Lithium-induced nephrogenic diabetes insipidus: the protocol of a randomized controlled trial

Author

Fotso Soh, Jocelyn, Torres-Platas, Susana G., Beaulieu, Serge, Mantere, Outi, Platt, Robert, Mucsi, Istvan, Saury, Sybille, Renaud, Suzane, Levinson, Andrea, Andreazza, Ana C., Mulsant, Benoit H., Müller, Daniel, Schaffer, Ayal, Dols, Annemiek, Cervantes, Pablo, Low, Nancy CP, Herrmann, Nathan, Christensen, Birgitte M., Trepiccione, Francesco, Rajji, Tarek, and Rej, Soham

Published
2018
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