517 results on '"Trelle, Sven"'
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2. Thiazides for kidney stone recurrence prevention
- Author
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Bargagli, Matteo, Trelle, Sven, Bonny, Olivier, and Fuster, Daniel G.
- Published
- 2024
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3. VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe
- Author
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Salmanton-García, Jon, Wipfler, Pauline, Valle-Simón, Paula, Merakou, Christina, Kopsidas, Ioannis, Bethe, Ullrich, Steinbach, Angela, Spivak, Orly, Součková, Lenka, Mendonça, Maria Amélia, Koniordou, Markela, Hellemans, Margot, Frías-Iniesta, Jesus, Davis, Ruth Joanna, Barta, Imre, Azzini, Anna Maria, Askling, Helena H., Argyropoulos, Christos D., Álvarez-Barco, Elena, Akova, Murat, Bonten, Marc M.J., Cohen-Kandli, Miriam, Cox, Rebecca Jane, Flisiak, Robert, Husa, Petr, Jancoriene, Ligita, Koscalova, Alena, Launay, Odile, Lundgren, Jens, Mallon, Patrick, Marques, Laura, Nauclér, Pontus, Ochando, Jordi, Pana, Zoi-Dorothea, Tacconelli, Evelina, Tóth, Krisztina, Trelle, Sven, van Damme, Pierre, Zaoutis, Theoklis E., Zeitlinger, Markus, Albus, Kerstin, Stewart, Fiona A., Hofstraat, Sanne H.I., Bruijning-Verhagen, Patricia, and Cornely, Oliver A.
- Published
- 2023
- Full Text
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4. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
- Author
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Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. 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Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt
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- 2022
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5. StOP? II trial: cluster randomized clinical trial to test the implementation of a toolbox for structured communication in the operating room—study protocol
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Keller, Sandra, Tschan, Franziska, Semmer, Norbert K., Trelle, Sven, Manser, Tanja, and Beldi, Guido
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- 2022
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6. Feasibility of symptom monitoring in head and neck cancer follow-up
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Müller, Simon, additional, Stadler, Thomas, additional, Rajan, Gunesh, additional, Morand, Grégoire, additional, Hool, Sara-Lynn, additional, Balermpas, Panagiotis, additional, Schanne, Daniel, additional, Nannen, Timo, additional, Limacher, Andreas, additional, Chan, Samantha, additional, Trelle, Sven, additional, Elicin, Olgun, additional, and Giger, Roland, additional
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- 2024
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7. Decision-Making for Preventive Interventions in Asymptomatic Patients.
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Raabe, Andreas, Fischer, Urs, Rothwell, Peter M., Luengo-Fernandez, Ramon, Bervini, David, Goldberg, Johannes, Trelle, Sven, Gralla, Jan, Beck, Jürgen, and Zubak, Irena
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- 2024
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8. Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence
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Dhayat, Nasser A, Bonny, Olivier, Roth, Beat, Christe, Andreas, Ritter, Alexander, Mohebbi, Nilufar, Faller, Nicolas, Pellegrini, Lisa, Bedino, Giulia, Venzin, Reto M, Grosse, Philipp, Hüsler, Carina, Koneth, Irene, Bucher, Christian, Del Giorno, Rosaria, Gabutti, Luca, Mayr, Michael, Odermatt, Urs, Buchkremer, Florian, Ernandez, Thomas, Stoermann-Chopard, Catherine, Teta, Daniel, Vogt, Bruno, Roumet, Marie, Tamò, Luca, Cereghetti, Grazia M, Trelle, Sven, and Fuster, Daniel G
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570 Life sciences ,biology ,General Medicine ,610 Medicine & health - Abstract
BACKGROUND Nephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose-response data are also limited. METHODS In this double-blind trial, we randomly assigned patients with recurrent calcium-containing kidney stones to receive hydrochlorothiazide at a dose of 12.5 mg, 25 mg, or 50 mg once daily or placebo once daily. The main objective was to investigate the dose-response effect for the primary end point, a composite of symptomatic or radiologic recurrence of kidney stones. Radiologic recurrence was defined as the appearance of new stones on imaging or the enlargement of preexisting stones that had been observed on the baseline image. Safety was also assessed. RESULTS In all, 416 patients underwent randomization and were followed for a median of 2.9 years. A primary end-point event occurred in 60 of 102 patients (59%) in the placebo group, in 62 of 105 patients (59%) in the 12.5-mg hydrochlorothiazide group (rate ratio vs. placebo, 1.33; 95% confidence interval [CI], 0.92 to 1.93), in 61 of 108 patients (56%) in the 25-mg group (rate ratio, 1.24; 95% CI, 0.86 to 1.79), and in 49 of 101 patients (49%) in the 50-mg group (rate ratio, 0.92; 95% CI, 0.63 to 1.36). There was no relation between the hydrochlorothiazide dose and the occurrence of a primary end-point event (P = 0.66). Hypokalemia, gout, new-onset diabetes mellitus, skin allergy, and a plasma creatinine level exceeding 150% of the baseline level were more common among patients who received hydrochlorothiazide than among those who received placebo. CONCLUSIONS Among patients with recurrent kidney stones, the incidence of recurrence did not appear to differ substantially among patients receiving hydrochlorothiazide once daily at a dose of 12.5 mg, 25 mg, or 50 mg or placebo once daily. (Funded by the Swiss National Science Foundation and Inselspital; NOSTONE ClinicalTrials.gov number, NCT03057431.).
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- 2023
9. Series: Pragmatic trials and real world evidence: Paper 8. Data collection and management
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Meinecke, Anna-Katharina, Welsing, Paco, Kafatos, George, Burke, Des, Trelle, Sven, Kubin, Maria, Nachbaur, Gaelle, Egger, Matthias, and Zuidgeest, Mira
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- 2017
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10. Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
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Fischer, Urs, primary, Koga, Masatoshi, additional, Strbian, Daniel, additional, Branca, Mattia, additional, Abend, Stefanie, additional, Trelle, Sven, additional, Paciaroni, Maurizio, additional, Thomalla, Götz, additional, Michel, Patrik, additional, Nedeltchev, Krassen, additional, Bonati, Leo H., additional, Ntaios, George, additional, Gattringer, Thomas, additional, Sandset, Else-Charlotte, additional, Kelly, Peter, additional, Lemmens, Robin, additional, Sylaja, P.N., additional, Aguiar de Sousa, Diana, additional, Bornstein, Natan M., additional, Gdovinova, Zuzana, additional, Yoshimoto, Takeshi, additional, Tiainen, Marjaana, additional, Thomas, Helen, additional, Krishnan, Manju, additional, Shim, Gek C., additional, Gumbinger, Christoph, additional, Vehoff, Jochen, additional, Zhang, Liqun, additional, Matsuzono, Kosuke, additional, Kristoffersen, Espen, additional, Desfontaines, Philippe, additional, Vanacker, Peter, additional, Alonso, Angelika, additional, Yakushiji, Yusuke, additional, Kulyk, Caterina, additional, Hemelsoet, Dimitri, additional, Poli, Sven, additional, Paiva Nunes, Ana, additional, Caracciolo, Nicoletta, additional, Slade, Peter, additional, Demeestere, Jelle, additional, Salerno, Alexander, additional, Kneihsl, Markus, additional, Kahles, Timo, additional, Giudici, Daria, additional, Tanaka, Kanta, additional, Räty, Silja, additional, Hidalgo, Rea, additional, Werring, David J., additional, Göldlin, Martina, additional, Arnold, Marcel, additional, Ferrari, Cecilia, additional, Beyeler, Seraina, additional, Fung, Christian, additional, Weder, Bruno J., additional, Tatlisumak, Turgut, additional, Fenzl, Sabine, additional, Rezny-Kasprzak, Beata, additional, Hakim, Arsany, additional, Salanti, Georgia, additional, Bassetti, Claudio, additional, Gralla, Jan, additional, Seiffge, David J., additional, Horvath, Thomas, additional, and Dawson, Jesse, additional
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- 2023
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11. Optimising prescribing in older adults with multimorbidity and polypharmacy in primary care (OPTICA): cluster randomised clinical trial
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Jungo, Katharina Tabea, primary, Ansorg, Anna-Katharina, additional, Floriani, Carmen, additional, Rozsnyai, Zsofia, additional, Schwab, Nathalie, additional, Meier, Rahel, additional, Valeri, Fabio, additional, Stalder, Odile, additional, Limacher, Andreas, additional, Schneider, Claudio, additional, Bagattini, Michael, additional, Trelle, Sven, additional, Spruit, Marco, additional, Schwenkglenks, Matthias, additional, Rodondi, Nicolas, additional, and Streit, Sven, additional
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- 2023
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12. Series: Pragmatic trials and real world evidence: Paper 6. Outcome measures in the real world
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Welsing, Paco M., Oude Rengerink, Katrien, Collier, Sue, Eckert, Laurent, van Smeden, Maarten, Ciaglia, Antonio, Nachbaur, Gaelle, Trelle, Sven, Taylor, Aliki J., Egger, Matthias, and Goetz, Iris
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- 2017
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13. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
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da Costa, Bruno R, Reichenbach, Stephan, Keller, Noah, Nartey, Linda, Wandel, Simon, Jüni, Peter, and Trelle, Sven
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- 2017
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14. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)
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Henao-Restrepo, Ana Maria, Camacho, Anton, Longini, Ira M, Watson, Conall H, Edmunds, W John, Egger, Matthias, Carroll, Miles W, Dean, Natalie E, Diatta, Ibrahima, Doumbia, Moussa, Draguez, Bertrand, Duraffour, Sophie, Enwere, Godwin, Grais, Rebecca, Gunther, Stephan, Gsell, Pierre-Stéphane, Hossmann, Stefanie, Watle, Sara Viksmoen, Kondé, Mandy Kader, Kéïta, Sakoba, Kone, Souleymane, Kuisma, Eewa, Levine, Myron M, Mandal, Sema, Mauget, Thomas, Norheim, Gunnstein, Riveros, Ximena, Soumah, Aboubacar, Trelle, Sven, Vicari, Andrea S, Røttingen, John-Arne, and Kieny, Marie-Paule
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- 2017
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15. Prediction of RECRUITment In randomized clinical Trials (RECRUIT-IT)—rationale and design for an international collaborative study
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Kasenda, Benjamin, Liu, Junhao, Jiang, Yu, Gajewski, Byron, Wu, Cen, von Elm, Erik, Schandelmaier, Stefan, Moffa, Giusi, Trelle, Sven, Schmitt, Andreas Michael, Herbrand, Amanda K., Gloy, Viktoria, Speich, Benjamin, Hopewell, Sally, Hemkens, Lars G., Sluka, Constantin, McGill, Kris, Meade, Maureen, Cook, Deborah, Lamontagne, Francois, Tréluyer, Jean-Marc, Haidich, Anna-Bettina, Ioannidis, John P. A., Treweek, Shaun, and Briel, Matthias
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- 2020
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16. Optimising prescribing in older adults with multimorbidity and polypharmacy in primary care (OPTICA): cluster randomised clinical trial
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Jungo, Katharina Tabea; https://orcid.org/0000-0002-1782-1345, Ansorg, Anna-Katharina, Floriani, Carmen, Rozsnyai, Zsofia, Schwab, Nathalie, Meier, Rahel; https://orcid.org/0000-0001-8159-9753, Valeri, Fabio; https://orcid.org/0000-0002-2481-9737, Stalder, Odile, Limacher, Andreas; https://orcid.org/0000-0002-9094-9476, Schneider, Claudio, Bagattini, Michael, Trelle, Sven, Spruit, Marco, Schwenkglenks, Matthias; https://orcid.org/0000-0001-7217-1173, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, Streit, Sven; https://orcid.org/0000-0002-3813-4616, Jungo, Katharina Tabea; https://orcid.org/0000-0002-1782-1345, Ansorg, Anna-Katharina, Floriani, Carmen, Rozsnyai, Zsofia, Schwab, Nathalie, Meier, Rahel; https://orcid.org/0000-0001-8159-9753, Valeri, Fabio; https://orcid.org/0000-0002-2481-9737, Stalder, Odile, Limacher, Andreas; https://orcid.org/0000-0002-9094-9476, Schneider, Claudio, Bagattini, Michael, Trelle, Sven, Spruit, Marco, Schwenkglenks, Matthias; https://orcid.org/0000-0001-7217-1173, Rodondi, Nicolas; https://orcid.org/0000-0001-9083-6896, and Streit, Sven; https://orcid.org/0000-0002-3813-4616
- Abstract
OBJECTIVE To study the effects of a primary care medication review intervention centred around an electronic clinical decision support system (eCDSS) on appropriateness of medication and the number of prescribing omissions in older adults with multimorbidity and polypharmacy compared with a discussion about medication in line with usual care. DESIGN Cluster randomised clinical trial. SETTING Swiss primary care, between December 2018 and February 2021. PARTICIPANTS Eligible patients were ≥65 years of age with three or more chronic conditions and five or more long term medications. INTERVENTION The intervention to optimise pharmacotherapy centred around an eCDSS was conducted by general practitioners, followed by shared decision making between general practitioners and patients, and was compared with a discussion about medication in line with usual care between patients and general practitioners. MAIN OUTCOME MEASURES Primary outcomes were improvement in the Medication Appropriateness Index (MAI) and the Assessment of Underutilisation (AOU) at 12 months. Secondary outcomes included number of medications, falls, fractures, and quality of life. RESULTS In 43 general practitioner clusters, 323 patients were recruited (median age 77 (interquartile range 73-83) years; 45% (n=146) women). Twenty one general practitioners with 160 patients were assigned to the intervention group and 22 general practitioners with 163 patients to the control group. On average, one recommendation to stop or start a medication was reported to be implemented per patient. At 12 months, the results of the intention-to-treat analysis of the improvement in appropriateness of medication (odds ratio 1.05, 95% confidence interval 0.59 to 1.87) and the number of prescribing omissions (0.90, 0.41 to 1.96) were inconclusive. The same was the case for the per protocol analysis. No clear evidence was found for a difference in safety outcomes at the 12 month follow-up, but fewer safety events were reported in
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- 2023
17. Managing People and Data
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Rohner, Eliane, Bohlius, Julia, da Costa, Bruno R., and Trelle, Sven
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610 Medicine & health ,360 Social problems & social services - Published
- 2022
18. Synthesizing existing evidence to design future trials: survey of methodologists from European institutions
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Nikolakopoulou, Adriani, Trelle, Sven, Sutton, Alex J., Egger, Matthias, and Salanti, Georgia
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- 2019
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19. Efficacy of standard and low dose hydrochlorothiazide in the recurrence prevention of calcium nephrolithiasis (NOSTONE trial): protocol for a randomized double-blind placebo-controlled trial
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Dhayat, Nasser A., Faller, Nicolas, Bonny, Olivier, Mohebbi, Nilufar, Ritter, Alexander, Pellegrini, Lisa, Bedino, Giulia, Schönholzer, Carlo, Venzin, Reto M., Hüsler, Carina, Koneth, Irene, Del Giorno, Rosaria, Gabutti, Luca, Amico, Patrizia, Mayr, Michael, Odermatt, Urs, Buchkremer, Florian, Ernandez, Thomas, Stoermann-Chopard, Catherine, Teta, Daniel, Rintelen, Felix, Roumet, Marie, Irincheeva, Irina, Trelle, Sven, Tamò, Luca, Roth, Beat, Vogt, Bruno, and Fuster, Daniel G.
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- 2018
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20. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial
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Henao-Restrepo, Ana Maria, Longini, Ira M, Egger, Matthias, Dean, Natalie E, Edmunds, W John, Camacho, Anton, Carroll, Miles W, Doumbia, Moussa, Draguez, Bertrand, Duraffour, Sophie, Enwere, Godwin, Grais, Rebecca, Gunther, Stephan, Hossmann, Stefanie, Kondé, Mandy Kader, Kone, Souleymane, Kuisma, Eeva, Levine, Myron M, Mandal, Sema, Norheim, Gunnstein, Riveros, Ximena, Soumah, Aboubacar, Trelle, Sven, Vicari, Andrea S, Watson, Conall H, Kéïta, Sakoba, Kieny, Marie Paule, and Røttingen, John-Arne
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- 2015
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21. Optimizing Prescribing in Older Adults with Multimorbidity and Polypharmacy in Primary Care: A Cluster Randomized Clinical Trial (OPTICA Trial)
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Jungo, Katharina Tabea, primary, Ansorg, Anna-Katharina, additional, Floriani, Carmen, additional, Rozsnyai, Zsofia, additional, Schwab, Nathalie, additional, Meier, Rahel, additional, Valeri, Fabio, additional, Stalder, Odile, additional, Limacher, Andreas, additional, Schneider, Claudio, additional, Bagattini, Michael, additional, Trelle, Sven, additional, Spruit, Marco, additional, Schwenkglenks, Matthias, additional, Rodondi, Nicolas, additional, and Streit, Sven, additional
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- 2022
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22. Planning a future randomized clinical trial based on a network of relevant past trials
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Salanti, Georgia, Nikolakopoulou, Adriani, Sutton, Alex J., Reichenbach, Stephan, Trelle, Sven, Naci, Huseyin, and Egger, Matthias
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- 2018
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23. STOP? II trial: Cluster randomized clinical trial to test the implementation of a toolbox for structured communication in the operating room: Study protocol
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Keller, Sandra, primary, Tschan, Franziska, additional, Semmer, Norbert, additional, Trelle, Sven, additional, Manser, Tanja, additional, and Beldi, Guido, additional
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- 2022
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24. Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial
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Fischer, Urs, primary, Trelle, Sven, additional, Branca, Mattia, additional, Salanti, Georgia, additional, Paciaroni, Maurizio, additional, Ferrari, Cecilia, additional, Abend, Stefanie, additional, Beyeler, Seraina, additional, Strbian, Daniel, additional, Thomalla, Götz, additional, Ntaios, George, additional, Bonati, Leo H, additional, Michel, Patrik, additional, Nedeltchev, Krassen, additional, Gattringer, Thomas, additional, Sandset, Else Charlotte, additional, Kelly, Peter, additional, Lemmens, Robin, additional, Koga, Masatoshi, additional, Sylaja, Padmavathy N, additional, de Sousa, Diana Aguiar, additional, Bornstein, Natan M, additional, Gdovinova, Zuzana, additional, Seiffge, David J, additional, Gralla, Jan, additional, Horvath, Thomas, additional, and Dawson, Jesse, additional
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- 2022
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25. Meta-research: Using shared data to provide practical solutions for current research challenges
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Briel, Matthias, primary, Gayet-Ageron, Angèle, additional, and Trelle, Sven, additional
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- 2022
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26. Efficacy of topical progesterone versus topical clobetasol propionate in patients with vulvar Lichen sclerosus – A double-blind randomized phase II pilot study
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Günthert, Andreas R., primary, Limacher, Andreas, additional, Beltraminelli, Helmut, additional, Krause, Elke, additional, Mueller, Michael D., additional, Trelle, Sven, additional, Bobos, Pavlos, additional, and Jüni, Peter, additional
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- 2022
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27. Effect of initial treatment strategy on survival of patients with advanced-stage Hodgkin's lymphoma: a systematic review and network meta-analysis
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Skoetz, Nicole, Trelle, Sven, Rancea, Michaela, Haverkamp, Heinz, Diehl, Volker, Engert, Andreas, and Borchmann, Peter
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- 2013
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28. Combining follow-up and change data is valid in meta-analyses of continuous outcomes: a meta-epidemiological study
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da Costa, Bruno R., Nüesch, Eveline, Rutjes, Anne W., Johnston, Bradley C., Reichenbach, Stephan, Trelle, Sven, Guyatt, Gordon H., and Jüni, Peter
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- 2013
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29. Exploratory trials in mental health: anything to learn from other disciplines?
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Trelle, Sven
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- 2017
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30. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis
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Trelle, Sven, Reichenbach, Stephan, Wandel, Simon, Hildebrand, Pius, Tschannen, Beatrice, Villiger, Peter M, Egger, Matthias, and Jüni, Peter
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- 2011
31. Additional file 1 of StOP? II trial: cluster randomized clinical trial to test the implementation of a toolbox for structured communication in the operating room—study protocol
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Keller, Sandra, Tschan, Franziska, Semmer, Norbert K., Trelle, Sven, Manser, Tanja, and Beldi, Guido
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Additional file 1.
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- 2022
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32. Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results
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Pan, Hongchao, Peto, Richard, Henao-Restrepo, Ana-Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Abdool Karim, Quarraisha, Alejandria, Marissa M, Hernández García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K Srinath, Roses Periago, Mirta, Abi Hanna, Pierre, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah M, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez-Moreno, Carlos A, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Bayih, Abebe Genetu, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike B C, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting S, Como, Najada, Eustace, Joe, Gabunia, Tamar, García, Patricia J, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sibylle, Medina, Marco T, Mesa Rubio, María L, Miranda-Montoya, Maria C, Nel, Jeremy, Nunes, Estevao P, Perola, Markus, Portolés, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan A C, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Rottingen, Arne, Swaminathan, Soumya, and Ryan, Michael
- Abstract
BACKGROUND World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). METHODS We randomly assigned inpatients with Covid-19 equally between one of the trial drug regimens that was locally available and open control (up to five options, four active and the local standard of care). The intention-to-treat primary analyses examined in-hospital mortality in the four pairwise comparisons of each trial drug and its control (drug available but patient assigned to the same care without that drug). Rate ratios for death were calculated with stratification according to age and status regarding mechanical ventilation at trial entry. RESULTS At 405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including 651 to interferon plus lopinavir), and 4088 to no trial drug. Adherence was 94 to 96% midway through treatment, with 2 to 6% crossover. In total, 1253 deaths were reported (median day of death, day 8; interquartile range, 4 to 14). The Kaplan-Meier 28-day mortality was 11.8% (39.0% if the patient was already receiving ventilation at randomization and 9.5% otherwise). Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate ratio, 1.19; 95% CI, 0.89 to 1.59; P = 0.23), in 148 of 1399 patients receiving lopinavir and in 146 of 1372 receiving its control (rate ratio, 1.00; 95% CI, 0.79 to 1.25; P = 0.97), and in 243 of 2050 patients receiving interferon and in 216 of 2050 receiving its control (rate ratio, 1.16; 95% CI, 0.96 to 1.39; P = 0.11). No drug definitely reduced mortality, overall or in any subgroup, or reduced initiation of ventilation or hospitalization duration. CONCLUSIONS These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay. (Funded by the World Health Organization; ISRCTN Registry number, ISRCTN83971151; ClinicalTrials.gov number, NCT04315948.).
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- 2022
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33. Authors' reply
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Jüni, Peter, Nüesch, Eveline, and Trelle, Sven
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- 2010
34. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
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Wandel, Simon, Jüni, Peter, Tendal, Britta, Nüesch, Eveline, Villiger, Peter M, Welton, Nicky J, Reichenbach, Stephan, and Trelle, Sven
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- 2010
35. Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study
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Nüesch, Eveline, Trelle, Sven, Reichenbach, Stephan, Rutjes, Anne W S, Tschannen, Beatrice, Altman, Douglas G, Egger, Matthias, and Jüni, Peter
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- 2010
36. The effects of excluding patients from the analysis in randomised controlled trials: meta-epidemiological study
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Nüesch, Eveline, Trelle, Sven, Reichenbach, Stephan, Rutjes, Anne W S, Bürgi, Elizabeth, Scherer, Martin, Altman, Douglas G, and Jüni, Peter
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- 2009
37. Disagreements in meta-analyses using outcomes measured on continuous or rating scales: observer agreement study
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Tendal, Britta, Higgins, Julian P T, Jüni, Peter, Hróbjartsson, Asbjørn, Trelle, Sven, Nüesch, Eveline, Wandel, Simon, Jørgensen, Anders W, Gesser, Katarina, Ilsøe-Kristensen, Søren, and Gøtzsche, Peter C
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- 2009
38. Improved Effectiveness of Partner Notification for Patients with Sexually Transmitted Infections: Systematic Review
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Trelle, Sven, Shang, Aijing, Nartey, Linda, Cassell, Jackie A., and Low, Nicola
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- 2007
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39. The Swiss cohort of elderly patients with venous thromboembolism (SWITCO65+): rationale and methodology
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Méan, Marie, Righini, Marc, Jaeger, Kurt, Beer, Hans-Jürg, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Lämmle, Bernhard, Cornuz, Jacques, Angelillo-Scherrer, Anne, Rodondi, Nicolas, Limacher, Andreas, Trelle, Sven, Matter, Christian M., Husmann, Marc, Banyai, Martin, Aschwanden, Markus, Egloff, Michael, Mazzolai, Lucia, Hugli, Olivier, Bounameaux, Henri, and Aujesky, Drahomir
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- 2013
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40. Design and establishment of a biobank in a multicenter prospective cohort study of elderly patients with venous thromboembolism (SWITCO65+)
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Méan, Marie, Aujesky, Drahomir, Lämmle, Bernhard, Gerschheimer, Christiane, Trelle, Sven, and Angelillo-Scherrer, Anne
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- 2013
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41. Percutaneous closure of patent foramen ovale in patients with cryptogenic embolism: a network meta-analysis
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Stortecky, Stefan, da Costa, Bruno R., Mattle, Heinrich P., Carroll, John, Hornung, Marius, Sievert, Horst, Trelle, Sven, Windecker, Stephan, Meier, Bernhard, and Jüni, Peter
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- 2015
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42. Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials
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Bohlius, Julia, Schmidlin, Kurt, Brillant, Corinne, Schwarzer, Guido, Trelle, Sven, Seidenfeld, Jerome, Zwahlen, Marcel, Clarke, Michael, Weingart, Olaf, Kluge, Sabine, Piper, Margaret, Rades, Dirk, Steensma, David P, Djulbegovic, Benjamin, Fey, Martin F, Ray-Coquard, Isabelle, Machtay, Mitchell, Moebus, Volker, Thomas, Gillian, Untch, Michael, Schumacher, Martin, Egger, Matthias, and Engert, Andreas
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- 2009
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43. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial
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Blum, Manuel R, primary, Sallevelt, Bastiaan T G M, additional, Spinewine, Anne, additional, O’Mahony, Denis, additional, Moutzouri, Elisavet, additional, Feller, Martin, additional, Baumgartner, Christine, additional, Roumet, Marie, additional, Jungo, Katharina Tabea, additional, Schwab, Nathalie, additional, Bretagne, Lisa, additional, Beglinger, Shanthi, additional, Aubert, Carole E, additional, Wilting, Ingeborg, additional, Thevelin, Stefanie, additional, Murphy, Kevin, additional, Huibers, Corlina J A, additional, Drenth-van Maanen, A Clara, additional, Boland, Benoit, additional, Crowley, Erin, additional, Eichenberger, Anne, additional, Meulendijk, Michiel, additional, Jennings, Emma, additional, Adam, Luise, additional, Roos, Marvin J, additional, Gleeson, Laura, additional, Shen, Zhengru, additional, Marien, Sophie, additional, Meinders, Arend-Jan, additional, Baretella, Oliver, additional, Netzer, Seraina, additional, de Montmollin, Maria, additional, Fournier, Anne, additional, Mouzon, Ariane, additional, O’Mahony, Cian, additional, Aujesky, Drahomir, additional, Mavridis, Dimitris, additional, Byrne, Stephen, additional, Jansen, Paul A F, additional, Schwenkglenks, Matthias, additional, Spruit, Marco, additional, Dalleur, Olivia, additional, Knol, Wilma, additional, Trelle, Sven, additional, and Rodondi, Nicolas, additional
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- 2021
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44. Prevalence of Iodine-Induced Hyperthyroidism After Administration of Iodinated Contrast During Radiographic Procedures: A Systematic Review and Meta-Analysis of the Literature
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Bervini, Sandrina, primary, Trelle, Sven, additional, Kopp, Peter, additional, Stettler, Christoph, additional, and Trepp, Roman, additional
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- 2021
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45. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial
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UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, UCL - SSS/IRSS - Institut de recherche santé et société, Blum, Manuel R, Sallevelt, Bastiaan T G M, Spinewine, Anne, O’Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E, Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J A, Drenth-van Maanen, A Clara, Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J, Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend-Jan, Baretella, Oliver, Netzer, Seraina, de Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O’Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A F, Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, Rodondi, Nicolas, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, UCL - SSS/IRSS - Institut de recherche santé et société, Blum, Manuel R, Sallevelt, Bastiaan T G M, Spinewine, Anne, O’Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E, Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J A, Drenth-van Maanen, A Clara, Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J, Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend-Jan, Baretella, Oliver, Netzer, Seraina, de Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O’Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A F, Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, and Rodondi, Nicolas
- Abstract
Objective: To examine the effect of optimising drug treatment on drug related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design: Cluster randomised controlled trial. Setting: 110 clusters of inpatient wards within university based hospitals in four European countries (Switzerland, Netherlands, Belgium, and Republic of Ireland) defined by attending hospital doctors. Participants: 2008 older adults (≥70 years) with multimorbidity (≥3 chronic conditions) and polypharmacy (≥5 drugs used long term). Intervention: Clinical staff clusters were randomised to usual care or a structured pharmacotherapy optimisation intervention performed at the individual level jointly by a doctor and a pharmacist, with the support of a clinical decision software system deploying the screening tool of older person’s prescriptions and screening tool to alert to the right treatment (STOPP/START) criteria to identify potentially inappropriate prescribing. Main outcome measure: Primary outcome was first drug related hospital admission within 12 months. Results: 2008 older adults (median nine drugs) were randomised and enrolled in 54 intervention clusters (963 participants) and 56 control clusters (1045 participants) receiving usual care. In the intervention arm, 86.1% of participants (n=789) had inappropriate prescribing, with a mean of 2.75 (SD 2.24) STOPP/START recommendations for each participant. 62.2% (n=491) had ≥1 recommendation successfully implemented at two months, predominantly discontinuation of potentially inappropriate drugs. In the intervention group, 211 participants (21.9%) experienced a first drug related hospital admission compared with 234 (22.4%) in the control group. In the intention-to-treat analysis censored for death as competing event (n=375, 18.7%), the hazard ratio for first drug related hospital admission was 0.95 (95% confidence interval 0.77 to 1.17). In the per protocol analysis, the hazard ratio for a drug relate
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- 2021
46. Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
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UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de médecine interne générale, WHO Solidarity Trial Consortium, Pan, Hongchao, Peto, Richard, Henao-Restrepo, Ana-Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Abdool Karim, Quarraisha, Alejandria, Marissa M, Hernández García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K Srinath, Roses Periago, Mirta, Abi Hanna, Pierre, Ader, Florence, Al-Bader, Abdullah M, Alhasawi, Almonther, Allum, Emma, Alotaibi, Athari, Alvarez-Moreno, Carlos A, Appadoo, Sheila, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Bellani, Samir, Branca, Mattia, Cappel-Porter, Heike B C, Cerrato, Nery, Chow, Ting S, Como, Najada, Eustace, Joe, García, Patricia J, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Maguire, Teresa, Manevska, Suzana, Manuel, Oriol, McGinty, Sibylle, Medina, Marco T, Mesa Rubio, María L, Miranda-Montoya, Maria C, Nel, Jeremy, Nunes, Estevao P, Perola, Markus, Portolés, Antonio, Rasmin, Menaldi R, Raza, Aun, Rees, Helen, Reges, Paula P S, Rogers, Chris A, Salami, Kolawole, Salvadori, Marina I, Sinani, Narvina, Sterne, Jonathan A C, Stevanovikj, Milena, Tacconelli, Evelina, Tikkinen, Kari A O, Trelle, Sven, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Belkhir, Leïla, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de médecine interne générale, WHO Solidarity Trial Consortium, Pan, Hongchao, Peto, Richard, Henao-Restrepo, Ana-Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Abdool Karim, Quarraisha, Alejandria, Marissa M, Hernández García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K Srinath, Roses Periago, Mirta, Abi Hanna, Pierre, Ader, Florence, Al-Bader, Abdullah M, Alhasawi, Almonther, Allum, Emma, Alotaibi, Athari, Alvarez-Moreno, Carlos A, Appadoo, Sheila, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Bellani, Samir, Branca, Mattia, Cappel-Porter, Heike B C, Cerrato, Nery, Chow, Ting S, Como, Najada, Eustace, Joe, García, Patricia J, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Maguire, Teresa, Manevska, Suzana, Manuel, Oriol, McGinty, Sibylle, Medina, Marco T, Mesa Rubio, María L, Miranda-Montoya, Maria C, Nel, Jeremy, Nunes, Estevao P, Perola, Markus, Portolés, Antonio, Rasmin, Menaldi R, Raza, Aun, Rees, Helen, Reges, Paula P S, Rogers, Chris A, Salami, Kolawole, Salvadori, Marina I, Sinani, Narvina, Sterne, Jonathan A C, Stevanovikj, Milena, Tacconelli, Evelina, Tikkinen, Kari A O, Trelle, Sven, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, and Belkhir, Leïla
- Abstract
BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). METHODS: We randomly assigned inpatients with Covid-19 equally between one of the trial drug regimens that was locally available and open control (up to five options, four active and the local standard of care). The intention-to-treat primary analyses examined in-hospital mortality in the four pairwise comparisons of each trial drug and its control (drug available but patient assigned to the same care without that drug). Rate ratios for death were calculated with stratification according to age and status regarding mechanical ventilation at trial entry. RESULTS: At 405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including 651 to interferon plus lopinavir), and 4088 to no trial drug. Adherence was 94 to 96% midway through treatment, with 2 to 6% crossover. In total, 1253 deaths were reported (median day of death, day 8; interquartile range, 4 to 14). The Kaplan-Meier 28-day mortality was 11.8% (39.0% if the patient was already receiving ventilation at randomization and 9.5% otherwise). Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate ratio, 1.19; 95% CI, 0.89 to 1.59; P = 0.23), in 148 of 1399 patients receiving lopinavir and in 146 of 1372 receiving its control (rate ratio, 1.00; 95% CI, 0.79 to 1.25; P = 0.97), and in 243 of 2050 patients receiving interferon and in 216 of 2050 receiving its control (rate ratio, 1.16; 95% CI, 0.96 to 1.39; P = 0.11).
- Published
- 2021
47. Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
- Author
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WHO Solidarity Trial Consortium, Pan, Hongchao, Peto, Richard, Henao-Restrepo, Ana-Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Abdool Karim, Quarraisha, Alejandria, Marissa MM, Hernández García, César, Kieny, Marie Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K Srinath, Roses Periago, Mirta, Abi Hanna, Pierre, Ader, Florence, Al-Bader, Abdullah AM, Alhasawi, Almonther, Allum, Emma, Alotaibi, Athari, Alvarez-Moreno, Carlos CA, Appadoo, Sheila, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Bellani, Samir, Branca, Mattia, Cappel-Porter, Heike HBC, Cerrato, Nery, Chow, Ting TS, Como, Najada, Eustace, Joe, García, Patricia J, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Tahiri Joutei Hassani, Mehdi, Hassany, Mohamed, Hites, Maya, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Kirwan, Jana, Kumar, Princy Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Maguire, Teresa, Manevska, Suzana, Manuel, Oriol, McGinty, Sibylle, Medina, Marco T, Mesa Rubio, María ML, Miranda-Montoya, Maria MC, Nel, Jeremy, Nunes, Estevao EP, Perola, Markus, Portolés, Antonio, Rasmin, Menaldi MR, Raza, Aun, Rees, Helen, Reges, Paula PPS, Rogers, Chris A, Salami, Kolawole, Salvadori, Marina I, Sinani, Narvina, Sterne, Jonathan A C, Stevanovikj, Milena, Tacconelli, Evelina, Tikkinen, Kari KAO, Trelle, Sven, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, WHO Solidarity Trial Consortium, Pan, Hongchao, Peto, Richard, Henao-Restrepo, Ana-Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Abdool Karim, Quarraisha, Alejandria, Marissa MM, Hernández García, César, Kieny, Marie Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K Srinath, Roses Periago, Mirta, Abi Hanna, Pierre, Ader, Florence, Al-Bader, Abdullah AM, Alhasawi, Almonther, Allum, Emma, Alotaibi, Athari, Alvarez-Moreno, Carlos CA, Appadoo, Sheila, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Bellani, Samir, Branca, Mattia, Cappel-Porter, Heike HBC, Cerrato, Nery, Chow, Ting TS, Como, Najada, Eustace, Joe, García, Patricia J, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Tahiri Joutei Hassani, Mehdi, Hassany, Mohamed, Hites, Maya, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Kirwan, Jana, Kumar, Princy Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Maguire, Teresa, Manevska, Suzana, Manuel, Oriol, McGinty, Sibylle, Medina, Marco T, Mesa Rubio, María ML, Miranda-Montoya, Maria MC, Nel, Jeremy, Nunes, Estevao EP, Perola, Markus, Portolés, Antonio, Rasmin, Menaldi MR, Raza, Aun, Rees, Helen, Reges, Paula PPS, Rogers, Chris A, Salami, Kolawole, Salvadori, Marina I, Sinani, Narvina, Sterne, Jonathan A C, Stevanovikj, Milena, Tacconelli, Evelina, Tikkinen, Kari KAO, Trelle, Sven, Zaid, Hala, Røttingen, John-Arne, and Swaminathan, Soumya
- Abstract
World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19)., info:eu-repo/semantics/published
- Published
- 2021
48. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): Cluster randomised controlled trial
- Author
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Apotheek Opleiding, Apotheek, Apotheek Klinische Farmacie, MS Geriatrie, Circulatory Health, Blum, Manuel R., Sallevelt, Bastiaan T.G.M., Spinewine, Anne, O'Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E., Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J.A., Clara Drenth-Van Maanen, A., Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J., Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend Jan, Baretella, Oliver, Netzer, Seraina, De Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O'Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A.F., Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, Rodondi, Nicolas, Apotheek Opleiding, Apotheek, Apotheek Klinische Farmacie, MS Geriatrie, Circulatory Health, Blum, Manuel R., Sallevelt, Bastiaan T.G.M., Spinewine, Anne, O'Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E., Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J.A., Clara Drenth-Van Maanen, A., Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J., Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend Jan, Baretella, Oliver, Netzer, Seraina, De Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O'Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A.F., Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, and Rodondi, Nicolas
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- 2021
49. Factors determining the success of radiofrequency denervation in lumbar facet joint pain: a prospective study
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Streitberger, Konrad, Müller, Tina, Eichenberger, Urs, Trelle, Sven, and Curatolo, Michele
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- 2011
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50. A pain assessment scale for population-based studies: Development and validation of the Pain Module of the Standard Evaluation Questionnaire
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Müller, Urs, Tänzler, Kristina, Bürger, Alexandra, Staub, Lukas, Tamcan, Özgür, Roeder, Christoph, Jüni, Peter, and Trelle, Sven
- Published
- 2008
- Full Text
- View/download PDF
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