5,397 results on '"Treiman, A"'
Search Results
2. The stability and developmental interplay of word reading and spelling: a cross-linguistic longitudinal study from kindergarten to grade 4
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Furnes, Bjarte, Elwér, Åsa, Samuelsson, Stefan, Treiman, Rebecca, and Olson, Richard K.
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- 2024
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3. Measures of the quality of spelling errors as predictors of later spelling performance
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Treiman, Rebecca, Kessler, Brett, Hulslander, Jacqueline, Olson, Richard K., Willcutt, Erik, and Wadsworth, Sally
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- 2024
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4. Understanding Myeloma-Related Information Needs and Communication Preferences Within Black American Communities: An Exploratory Study
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Esquivel, N. S., Tzeng, J. P., Treiman, K., Husick, C. H., Sheridan, J., Ortiz-Ravick, L., Sae-Hau, M., Brown, L., DeMairo, K., Bell, N., Disare, K., and Weiss, E. S.
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- 2024
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5. On the relationship between word reading ability and spelling ability
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Treiman, Rebecca, Hulslander, Jacqueline, Willcutt, Erik G., Pennington, Bruce F., and Olson, Richard K.
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- 2024
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6. Reducing risk for chronic disease: evaluation of a collective community approach to sustainable evidence-based health programming
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Oestman, Katherine, Rechis, Ruth, Williams, Pamela A., Brown, Jill A., Treiman, Katherine, Zulkiewicz, Brittany, Walsh, Jr., Michael T., Basen-Engquist, Karen, Rodriguez, Trina, Chennisi, Catherine, Macneish, Amber, Neff, Alise, Pomeroy, Mike, Bhojani, Faiyaz A., and Hawk, Ernest
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- 2024
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7. The primacy of morphology in English braille spelling: an analysis of bridging contractions
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Englebretson, Robert, Holbrook, M. Cay, Treiman, Rebecca, and Fischer-Baum, Simon
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- 2024
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8. The Primacy of Morphology in English Braille Spelling: An Analysis of Bridging Contractions
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Englebretson, Robert, Holbrook, M. Cay, Treiman, Rebecca, and Fischer-Baum, Simon
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This study examines the use of braille contractions in a corpus of spelling tests from braille-reading children in grades 1-4, with particular attention to braille contractions that create mismatches with morphological structure. Braille is a tactile writing system that enables people who are blind or visually impaired to read and write. In English and many other languages, reading and writing braille is not simply a matter of transliterating between print letters and their braille equivalents; Unified English Braille (the official braille system used in the United States, Canada, the United Kingdom, and several other English-speaking countries) contains 180 contractions--one or more braille cells that represent whole words or strings of letters. In some words, the prescriptive rules for correct braille usage cause contractions to bridge morphological boundaries and to obscure the spellings of stems and affixes. We demonstrate that, when the prescriptive rules for correct braille usage flout morphological structure, young braille spellers generally follow the morphology rather than the orthographic rules. This work establishes that morphology matters for young braille learners. We discuss the potential impact of our findings on braille research, development, and pedagogy, and we suggest ways in which our findings contribute to understanding the nature of orthographic morphemes and the place of braille in the reading sciences. [This is the online first version of an article published in "Morphology."]
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- 2023
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9. Astrobiological Potential of Rocks Acquired by the Perseverance Rover at a Sedimentary Fan Front in Jezero Crater, Mars
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T. Bosak, D. L. Shuster, E. L. Scheller, S. Siljeström, M. J. Zawaski, L. Mandon, J. I. Simon, B. P. Weiss, K. M. Stack, E. N. Mansbach, A. H. Treiman, K. C. Benison, A. J. Brown, A. D. Czaja, K. A. Farley, E. M. Hausrath, K. Hickman‐Lewis, C. D. K. Herd, J. R. Johnson, L. E. Mayhew, M. E. Minitti, K. H. Williford, B. V. Wogsland, M.‐P. Zorzano, A. C. Allwood, H. E. F. Amundsen, J. F. Bell III, K. Benzerara, S. Bernard, O. Beyssac, D. K. Buckner, M. Cable, F. Calef III, G. Caravaca, D. C. Catling, E. Clavé, E. Cloutis, B. A. Cohen, A. Cousin, E. Dehouck, A. G. Fairén, D. T. Flannery, T. Fornaro, O. Forni, T. Fouchet, E. Gibbons, F. Gomez Gomez, S. Gupta, K. P. Hand, J. A. Hurowitz, H. Kalucha, D. A. K. Pedersen, G. Lopes‐Reyes, J. N. Maki, S. Maurice, J. I. Nuñez, N. Randazzo, J. W. Rice Jr., C. Royer, M. A. Sephton, S. Sharma, A. Steele, C. D. Tate, K. Uckert, A. Udry, R. C. Wiens, and A. Williams
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Mars ,sedimentary geochemistry ,planetary geochemistry ,origin of life ,hydrothermal systems and weathering on other planets ,hydrology and fluvial processes ,Geology ,QE1-996.5 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract The Perseverance rover has collected seven oriented samples of sedimentary rocks, all likely older than the oldest signs of widespread life on Earth, at the exposed base of the western fan in Jezero crater, Mars. The samples include a sulfate‐ and clay‐bearing mudstone and sandstone, a fluvial sandstone from a stratigraphically low position at the fan front, and a carbonate‐bearing sandstone deposited above the sulfate‐bearing strata. All samples contain aqueously precipitated materials and most or all were aqueously deposited. Although the rover instruments have not confidently detected organic matter in the rocks from the fan front, the much more sensitive terrestrial instruments will still be able to search for remnants of prebiotic chemistries and past life, and study Mars's past habitability in the samples returned to Earth. The hydrated, sulfate‐bearing mudstone has the highest potential to preserve organic matter and biosignatures, whereas the carbonate‐bearing sandstones can be used to constrain when and for how long Jezero crater contained liquid water. Returned sample science analyses of sulfate, carbonate, clay, phosphate and igneous minerals as well as trace metals and volatiles that are present in the samples acquired at the fan front would provide transformative insights into past habitable environments on Mars, the evolution of its magnetic field, atmosphere and climate and the past and present cycling of atmospheric and crustal water, sulfur and carbon.
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- 2024
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10. Properties of the Nili Fossae Olivine-clay-carbonate lithology: orbital and in situ at S\'e\'itah
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Brown, Adrian J., Kah, Linda, Mandon, Lucia, Wiens, Roger, Pinet, Patrick, Clavé, Elise, Mouélic, Stéphane Le, Udry, Arya, Gasda, Patrick J., Royer, Clément, Hickman-Lewis11, Keyron, Cousin, Agnes, Simon, Justin I., Comellas14, Jade, Cloutis, Edward, Fouchet, Thierry, Fairén, Alberto G., Connell, Stephanie, Flannery, David, Horgan, Briony, Mayhew, Lisa, Treiman, Allan, Núñez, Jorge I., Wogsland, Brittan, Benzerara, Karim, Amundsen, Hans E. F., Quantin-Nataf, Cathy, Hand, Kevin P., Debaille, Vinciane, Essunfeld, Ari, Beck, Pierre, Tosca, Nicholas J., Madariaga, Juan M., and Ravanis, Eleni
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
We examine the observed properties of the Nili Fossae olivine-clay-carbonate lithology from orbital data and in situ by the Mars 2020 rover at the S\'e\'itah unit in Jezero crater, including: 1) composition (Liu, 2022) 2) grain size (Tice, 2022) 3) inferred viscosity (calculated based on geochemistry collected by SuperCam (Wiens, 2022)). Based on the low viscosity and distribution of the unit we postulate a flood lava origin for the olivine-clay-carbonate at S\'e\'itah. We include a new CRISM map of the clay 2.38 {\mu}m band and use in situ data to show that the clay in the olivine cumulate in the S\'e\'itah formation is consistent with talc or serpentine from Mars 2020 SuperCam LIBS and VISIR and MastCam-Z observations. We discuss two intertwining aspects of the history of the lithology: 1) the emplacement and properties of the cumulate layer within a lava lake, based on terrestrial analogs in the Pilbara, Western Australia, and using previously published models of flood lavas and lava lakes, and 2) the limited extent of post emplacement alteration, including clay and carbonate alteration (Clave, 2022; Mandon, 2022)., Comment: 34 pages, 15 figures
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- 2022
11. Rare earth element assessment in Jezero crater using the Planetary Instrument for X-ray Lithochemistry on the Mars 2020 rover Perseverance: A case study of cerium
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VanBommel, S.J., Sharma, S., Kizovski, T.V., Heirwegh, C.M., Christian, J.R., Knight, A.L., Ganly, B., Allwood, A.C., Hurowitz, J.A., Tice, M.M., Cable, M.L., Elam, W.T., Jones, M.W.M., Clark, B.C., Treiman, A.H., Schmidt, M.E., Liu, Y., and Das, A.
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- 2025
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12. Reducing risk for chronic disease: evaluation of a collective community approach to sustainable evidence-based health programming
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Katherine Oestman, Ruth Rechis, Pamela A. Williams, Jill A. Brown, Katherine Treiman, Brittany Zulkiewicz, Michael T. Walsh, Karen Basen-Engquist, Trina Rodriguez, Catherine Chennisi, Amber Macneish, Alise Neff, Mike Pomeroy, Faiyaz A. Bhojani, and Ernest Hawk
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Chronic disease ,Population health ,Implementation science ,Risk reduction behavior ,Program evaluation ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Community initiatives can shape health behaviors, such as physical activity and dietary habits, across a population and help reduce the risk of developing chronic disease. To achieve this goal and impact health outcomes, Pasadena Vibrant Community aimed to engage communities in an ongoing dialogue about the importance of healthy behaviors, implement and advance community-based strategies to promote health, and improve diet and physical activity behaviors. The initiative was centered around a collaboration between a backbone organization, steering committee, and 7 collaborating organizations funded to implement multicomponent, evidence-based programs.. The common agenda was detailed in a community action plan, which included 19 interventions targeting healthy eating and active living among adults and youth in Pasadena, Texas. Methods A mixed methods evaluation of the initiative was conducted over 4 years. Data sources included document reviews of quarterly progress reports (n = 86) and supplemental data reports (n = 16) provided by collaborating organizations, annual Steering Committee surveys (n = 4), and interviews conducted with staff from a subset of Collaborating Organizations (n = 4). Results The initiative reached over 50,000 community members per year through 19 evidence-based interventions and impacted health outcomes, including knowledge and adoption of healthy eating practices and increased physical activity. Thirty-one systems-level changes were implemented during the initiative, including 16 environmental changes. Steering Committee meetings and shared goals enabled connections, communication, and cooperation, which allowed Collaborating Organizations to address challenges and combine resources to deliver their programs. Conclusions Community initiatives can effectively permeate the community by reaching individuals, improving physical activity and dietary habits, and ensuring sustainability. Based on the experience reported here, the success of a community initiative can be facilitated if collaborating organizations come together to implement evidence-based interventions and tailor them to the community, and if they are empowered by significant leadership and supportive collaboration and aligned by a common agenda.
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- 2024
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13. No Dignity on the Floor : A Human Rights Argument for Adult-Sized Changing Tables in Public Restrooms in the United States
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TREIMAN, GEFFEN
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- 2023
14. Longitudinality Matters: Qualitative Perspectives on a Longitudinal Clinical Experience in a Psychiatry Residency Training Program
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Kinasz, Kathryn, Hasser, Caitlin, Hung, Erick, Pinard, Kerry-Ann, Treiman, Scott, and Peterson, Alissa
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- 2023
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15. To Punctuate, or Not to Punctuate? Grammatical and Prosodic Influences on Adults' Judgments of Comma Use
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Kemp, Nenagh and Treiman, Rebecca
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Purpose: Punctuation is traditionally seen to represent grammatical structures in writing, but some authors argue that it can also reflect the intonation and pauses of speech. In two experiments, we examined the influence of grammar and prosody on adults' judgments of comma placement. Method: University students rated the appropriateness of commas in various sentence structures. These included sentences in which the subject and verb were disrupted by a comma. These commas were ungrammatical, but prosodically appropriate, in that they marked where a slight pause could naturally occur in speech. Results: In Experiment 1, 192 students rated ungrammatical commas as more appropriate if they occurred at prosodic pause points than at no-pause points. In Experiment 2, 235 students rated prosodically appropriate commas as more appropriate if they were also grammatical than if they were not. Overall, participants with better written language skills distinguished more between grammatical and ungrammatical commas, but acceptance of prosodically appropriate commas occurred across levels of written language skill. Conclusion: Literate adults use prosody, as well as grammar, to judge the appropriateness of comma use. These findings have implications for theories of punctuation, and can inform debate on students' and teachers' treatment of punctuation.
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- 2023
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16. Predicting Later Spelling from Kindergarten Spelling in U.S., Australian, and Swedish Children
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Treiman, Rebecca, Hulslander, Jacqueline, Olson, Richard K., Samuelsson, Stefan, Elwér, Åsa, Furnes, Bjarte, and Byrne, Brian
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Purpose: Using data from 1,868 children from the US, Australia, and Sweden who took a 10-word spelling test in kindergarten and a standardized spelling test in Grades 1, 2, and (except for the Australian children) Grade 4, we examined two questions. First, does the quality of a child's errors on the kindergarten test help predict later spelling performance even after controlling for the number of correct responses on the kindergarten test? Second, does spelling develop at a faster pace in Swedish than in English? Method: We measured kindergarten error quality based on the number of letter additions, deletions, and substitutions by which each error differed from the correct spelling. Using mixed-model analyses, we examined the relationship of this and other variables to later spelling performance. Results: Kindergarten error quality contributed significantly to the prediction of later spelling performance even after consideration of the number of correct spellings in kindergarten and other relevant variables. The Swedish children showed more rapid growth in spelling than the U.S. and Australian children, a difference that may reflect the greater transparency of sound-to-spelling links in Swedish. Conclusion: Information from a spelling test that is typically discarded--information about the nature of the errors--has value.
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- 2023
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17. Spelling-to-Sound Translation for English Disyllables: Use of Long and Short Vowels before Single Medial Consonants
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Rebecca Treiman and Brett Kessler
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The English writing system is often seen as having rules that govern the choice between alternative pronunciations of letters but as having many exceptions to the rules. One postulated rule, the V¯|CV rule, is that a vowel is pronounced as long rather than short when it is followed by a single consonant letter plus a vowel letter. We find, in an analysis of English disyllabic words, that exceptions to the V¯|CV rule are not randomly scattered throughout the vocabulary. The use of long versus short vowels is systematically influenced by the identity of the vowel letter itself, the characteristics of the following consonant, and the identity of the word ending. In four studies with a total of 283 participants, we asked university students to pronounce disyllabic nonwords with medial vowel-consonant-vowel sequences and choose the better pronunciation of the first vowel, long or short. Participants were generally sensitive to the effects found in the vocabulary. However, participants used fewer long vowels than expected on the basis of the vocabulary statistics calculated for disyllabic words. We consider possible reasons for this difference and implications for statistical-learning views of reading. Given that the V¯|CV rule is sometimes taught as a part of phonics programs, we also consider implications for reading instruction.
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- 2023
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18. Letter Features as Predictors of Letter-Name Acquisition in Four Languages with Three Scripts
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Kim, Young-Suk Grace, Petscher, Yaacov, Treiman, Rebecca, and Kelcey, Benjamin
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To expand our understanding of script-general and script-specific principles in the learning of letter names, we examined how three characteristics of alphabet letters -- their frequency in printed materials, order in the alphabet, and visual similarity to other letters -- relate to children's letter-name knowledge in four languages with three distinct scripts (English [N = 318; M age = 4.90], Portuguese [N = 366; M age = 5.80], Korean [N = 168; M age = 5.48], and Hebrew [N = 645; M age = 5.42]). Explanatory item response modeling analysis showed that the frequency of letters in printed materials was consistently related to letter difficulty across the four languages. There were also moderation effects for letter difficulty in English and Korean, and for discriminatory power of letters in Korean. The results suggest that exposure to letters as measured by letter frequency is a language-general mechanism in the learning of alphabet letters. [This is the online first version of an article published in "Scientific Studies of Reading."]
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- 2020
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19. A systematic review of stage IVA cervical cancer treatment: Challenges in the management of an understudied group
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Hunsberger, Kyra S., Treiman, Sierra, Monk, Bradley J., Tewari, Krishnansu S., Taunk, Neil K., and Chase, Dana M.
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- 2024
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20. Prereaders' Knowledge about the Nature of Book Reading
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Farry-Thorn, Molly and Treiman, Rebecca
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Children's early knowledge and skills set the stage for later reading development. The present studies examined children's conceptual knowledge of reading prior to formal literacy instruction. Young children's knowledge about who is able to read books and what readers are reading when they read books has been studied primarily through interviews. However, conclusions from this research are limited by methodological concerns. In three experiments with a total of 105 U.S. preschoolers (ages 3 years, 1 month to 5 years, 5 months) we examined whether prereaders understand what part of a book is read, who can read, and who engages in reading. We created storybooks for Experiments 1 and 2, asking children questions about the print and what parts of a book an adult can read. In Experiment 3, we asked children questions about pictures of animals and adults looking at books. Although prereaders could generally locate letters and words in a book, they were still learning that it is this print, not the pictures, which a reader reads. Prereaders knew that adults but not animals have the ability to read, but many also indicated that engaging in the activity of reading does not require the ability to read. Children who cannot read are still in the process of learning that print is what a reader reads and that engaging in reading requires a special skill. Therefore, when formal literacy instruction begins, teachers should not overestimate the knowledge about print and reading that children have acquired from prior exposure to books.
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- 2022
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21. The PIXL Instrument on the Mars 2020 Perseverance Rover
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Allwood, Abigail C., Hurowitz, Joel A., Clark, Benton C., Cinquini, Luca, Davidoff, Scott, Denise, Robert W., Elam, W. Timothy, Foote, Marc C., Flannery, David T., Gerhard, James H., Grotzinger, John P., Heirwegh, Christopher M., Hernandez, Christina, Hodyss, Robert P., Jones, Michael W., Jorgensen, John Leif, Henneke, Jesper, Lawson, Peter R., Liu, Yang, MacDonald, Haley, McLennan, Scott M., Moore, Kelsey R., Nachon, Marion, Nemere, Peter, O'Neil, Lauren, Pedersen, David A. K., Sinclair, Kimberly P., Sondheim, Michael E., Song, Eugenie, Tallarida, Nicholas R., Tice, Michael M., Treiman, Alan, Uckert, Kyle, Wade, Lawrence A., Young, Jimmie D., and Zamani, Payam
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Physics - Instrumentation and Detectors ,Physics - Applied Physics - Abstract
The Planetary Instrument for X-ray Lithochemistry (PIXL) is a micro-focus X-ray fluorescence spectrometer mounted on the robotic arm of NASA's Perseverance rover. PIXL will acquire high spatial resolution observations of rock and soil chemistry, rapidly analyzing the elemental chemistry of a target surface. In 10 seconds, PIXL can use its powerful 120 micrometer diameter X-ray beam to analyze a single, sand-sized grain with enough sensitivity to detect major and minor rock-forming elements, as well as many trace elements. Over a period of several hours, PIXL can autonomously scan an area of the rock surface and acquire a hyperspectral map comprised of several thousand individual measured points., Comment: 2 pages, from 52nd Lunar and Planetary Science Conference, https://www.hou.usra.edu/meetings/lpsc2021/pdf/1591.pdf
- Published
- 2021
22. No Dignity on the Floor: A Human Rights Argument for Adult-Sized Changing Tables in Public Restrooms in the United States
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Geffen Treiman
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Public aspects of medicine ,RA1-1270 ,Social history and conditions. Social problems. Social reform ,HN1-995 - Abstract
Many individuals with disabilities utilize adult-sized changing tables to take care of their toileting needs with the help of a caregiver. These tables are not explicitly required by the Americans with Disabilities Act (ADA), and no legal case in the United States has yet addressed whether the ADA requires public restrooms to have adult changing tables. This paper draws on an analysis of op-eds and news articles published in the United States to explore how individuals with disabilities and their caregivers access public restrooms that do not provide adult-sized changing tables. These experiences demonstrate violations of the human rights to accessibility, integrity, and health as outlined in the Convention on the Rights of Persons with Disabilities. Utilizing a human rights analysis, I argue that adult-sized changing tables are inherently the same as toilets and that providing one but not the other in public facilities may constitute discrimination under the ADA. Finally, I briefly explore promising initiatives that would increase access to adult-sized changing tables in the United States.
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- 2023
23. Parental Participation in Their Infants’ Procedural Pain Alleviation with Nonpharmacologic Methods in Estonia
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Treiman-Kiveste, Airin, Kangasniemi, Mari, Kalda, Ruth, and Pölkki, Tarja
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- 2023
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24. Fe-Phosphates in the Jezero Crater Fan: Implications for Habitability and Sample Return
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T V Kizovski, M E Schmidt, L O'Neil, D Klevang, N Tosca, M Tice, M Cable, E Hausrath, C T Adcock, J Hurowitz, A Treiman, M Jones, F M McCubbin, A Allwood, Y Liu, S Sharma, B Clark, S VanBommel, J Christian, A Knight, J Labrie, P Lawson, D Catling, E Cloutis, L Wade, C Heirwegh, T. Elam, N Randazzo, and C D K Herd
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Lunar and Planetary Science and Exploration - Abstract
In the ~1000 sols since the Mars 2020 Perseverance rover landed on the floor of Jezero crater, it has traversed >23 km, carrying out analyses of the crater floor and western fan. The fan is comprised of sediments transported and deposited by streams that once flowed into Jezero crater in the late Noachian to early Hesperian[1]. Detailed investigation of the sediments and rocks of the western fan can thus provide insights into ancient fluvial to lacustrine environments on Mars, whether they were habitable, and/or if biosignatures maybe preserved.
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- 2024
25. Statistical Learning in Word Reading and Spelling across Languages and Writing Systems
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Treiman, Rebecca and Kessler, Brett
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Learning to read and spell involves learning about the written forms of words and how these are linked to language. Writing systems include formal patterns, which pertain to the appearance of written words, and functional patterns, which pertain to links between units of writing and units of language. We review the evidence that learners of a variety of writing systems extract some of these patterns through statistical learning. Statistical learning is often slow and incomplete, however, and direct instruction improves performance. Many studies have focused on statistical-learning skill as an ability of individual learners. We discuss some problems with this approach, arguing that it is more productive to attend to the statistical patterns that writing systems embody. Studies of these patterns and their learning can help explain similarities and differences in learning to read and spell across writing systems.
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- 2022
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26. Attitudes and Experiential Factors Associated with Completion of mt-sDNA Test Kit for Colorectal Cancer Screening
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Lila J. Finney Rutten PhD, MPH, Xuan Zhu PhD, Katherine Treiman PhD, MPH, Gabriel Madson PhD, Brian Southwell PhD, Leah Helmueller BS, Shama Alam PhD, Carlye Gates MPA, and Linda Squiers PhD
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Medicine (General) ,R5-920 - Abstract
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the United States. Despite the availability of multiple screening options, CRC screening is underutilized. We conducted a survey of patients (n = 2973) who were prescribed the multi-target stool DNA (mt-sDNA) screening test (commercialized as Cologuard ® and manufactured by Exact Sciences Corporation) to understand attitudes and experiences that influence test completion and likelihood of future test completion. Using exploratory factor analyses, we developed three scales: Perceived Effectiveness, Perceived Ease of Use, and Perceived Comfort.
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- 2023
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27. Mars volatile inventory and outgassing history
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Jakosky, Bruce M. and Treiman, Allan H.
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- 2023
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28. ASCEND: A randomized controlled trial of titration strategies for vagus nerve stimulation in drug-resistant epilepsy
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Afra, Pegah, Bagić, Anto, Benbadis, Selim, Nune, George, Fakhoury, Toufic, Helmers, Sandy, Winkel, Daniel, Kirmani, Batool, Oghlakian, Roger, Losey, Travis, Treiman, David, Bernstein, Lawrence, Macken, Michael, Madhavan, Deepak, Oommen, Kalarickal, Minecan, Daniela, Way, Jeffrey, Bagić, Anto I., and Verner, Ryan
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- 2023
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29. Double trouble: Using spellings of different lengths to represent vowel length in English
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Altmiller, Ruth, Treiman, Rebecca, and Kessler, Brett
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- 2023
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30. Documentation of Surface Fault Rupture and Ground-Deformation Features Produced by the 4 and 5 July 2019 Mw 6.4 and Mw 7.1 Ridgecrest Earthquake Sequence
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Ponti, Daniel J, Blair, James Luke, Rosa, Carla M, Thomas, Kate, Pickering, Alexandra J, Akciz, Sinan, Angster, Stephen, Avouac, Jean-Philipe, Bachhuber, Jeffrey, Bacon, Steven, Barth, Nicolas, Bennett, Scott, Blake, Kelly, Bork, Stephan, Brooks, Benjamin, Bullard, Thomas, Burgess, Paul, Chupik, Colin, Dawson, Timothy, DeFrisco, Michael, Delano, Jaime, DeLong, Stephen, Dolan, James, Donnellan, Andrea, DuRoss, Christopher, Ericksen, Todd, Frost, Erik, Funning, Gareth, Gold, Ryan, Graehl, Nicholas, Gutierrez, Carlos, Haddon, Elizabeth, Hatem, Alexandra, Helms, John, Hernandez, Janis, Hitchcock, Christopher, Holland, Peter, Hudnut, Kenneth, Kendrick, Katherine, Koehler, Richard, Kozaci, Ozgur, Ladinsky, Tyler, Leeper, Robert, Madugo, Christopher, Mareschal, Maxime, McDonald, James, McPhillips, Devin, Milliner, Christopher, Mongovin, Daniel, Morelan, Alexander, Nale, Stephanie, Nevitt, Johanna, O’Neal, Matt, Olson, Brian, Oskin, Michael, Padilla, Salena, Patton, Jason, Philibosian, Belle, Pierce, Ian, Pridmore, Cynthia, Roth, Nathaniel, Sandwell, David, Scharer, Katherine, Seitz, Gordon, Singleton, Drake, Smith-Konter, Bridget, Spangler, Eleanor, Swanson, Brian, Jobe, Jessica Thompson, Treiman, Jerome, Valencia, Francesca, Vanderwal, Joshua, Williams, Alana, Xu, Xiaohua, Zachariasen, Judith, Zimmerman, Jade, and Zinke, Robert
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Geophysics ,Geochemistry & Geophysics - Abstract
The Mw 6.4 and Mw 7.1 Ridgecrest earthquake sequence occurred on 4 and 5 July 2019 within the eastern California shear zone of southern California. Both events produced extensive surface faulting and ground deformation within Indian Wells Valley and Searles Valley. In the weeks following the earthquakes, more than six dozen scientists from government, academia, and the private sector carefully documented the surface faulting and ground-deformation features. As of December 2019, we have compiled a total of more than 6000 ground observations; approximately 1500 of these simply note the presence or absence of fault rupture or ground failure, but the remainder include detailed descriptions and other documentation, including tens of thousands of photographs. More than 1100 of these observations also include quantitative field measurements of displacement sense and magnitude. These field observations were supplemented bymapping of fault rupture and ground-deformation features directly in the field as well as by interpreting the location and extent of surface faulting and ground deformation from optical imagery and geodetic image products. We identified greater than 68 km of fault rupture produced by both earthquakes aswell as numerous sites of ground deformation resulting from liquefaction or slope failure. These observations comprise a dataset that is fundamental to understanding the processes that controlled this earthquake sequence and for improving earthquake hazard estimates in the region. This article documents the types of data collected during postearthquake field investigations, the compilation effort, and the digital data products resulting from these efforts.
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- 2020
31. Spiking activity in the human hippocampus prior to encoding predicts subsequent memory
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Urgolites, Zhisen J, Wixted, John T, Goldinger, Stephen D, Papesh, Megan H, Treiman, David M, Squire, Larry R, and Steinmetz, Peter N
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Neurodegenerative ,Neurosciences ,Mental Health ,Behavioral and Social Science ,Basic Behavioral and Social Science ,Clinical Research ,Underpinning research ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,1.2 Psychological and socioeconomic processes ,Aetiology ,Neurological ,Mental health ,Adult ,Female ,Hippocampus ,Humans ,Male ,Memory ,Prefrontal Cortex ,Recognition ,Psychology ,human hippocampus ,single-unit activity ,multiunit activity ,subsequent memory ,encoding - Abstract
Encoding activity in the medial temporal lobe, presumably evoked by the presentation of stimuli (postonset activity), is known to predict subsequent memory. However, several independent lines of research suggest that preonset activity also affects subsequent memory. We investigated the role of preonset and postonset single-unit and multiunit activity recorded from epilepsy patients as they completed a continuous recognition task. In this task, words were presented in a continuous series and eventually began to repeat. For each word, the patient's task was to decide whether it was novel or repeated. We found that preonset spiking activity in the hippocampus (when the word was novel) predicted subsequent memory (when the word was later repeated). Postonset activity during encoding also predicted subsequent memory, but was simply a continuation of preonset activity. The predictive effect of preonset spiking activity was much stronger in the hippocampus than in three other brain regions (amygdala, anterior cingulate, and prefrontal cortex). In addition, preonset and postonset activity around the encoding of novel words did not predict memory performance for novel words (i.e., correctly classifying the word as novel), and preonset and postonset activity around the time of retrieval did not predict memory performance for repeated words (i.e., correctly classifying the word as repeated). Thus, the only predictive effect was between preonset activity (along with its postonset continuation) at the time of encoding and subsequent memory. Taken together, these findings indicate that preonset hippocampal activity does not reflect general arousal/attention but instead reflects what we term "attention to encoding."
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- 2020
32. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial
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Chamberlain, James M, Kapur, Jaideep, Shinnar, Shlomo, Elm, Jordan, Holsti, Maija, Babcock, Lynn, Rogers, Alex, Barsan, William, Cloyd, James, Lowenstein, Daniel, Bleck, Thomas P, Conwit, Robin, Meinzer, Caitlyn, Cock, Hannah, Fountain, Nathan B, Underwood, Ellen, Connor, Jason T, Silbergleit, Robert, Gray, Emily, Gunter, Sonya, Fansler, Amy, Stevenson, Valerie, Bengelink, Erin, Harney, Deneil, Speers, Mickie, Black, Joy, Fisher, Natalie, Harsh, Donna, Ramakrishnan, Arthi, Harris, Lindsey, Bozeman, Nia, Spiteri, Aimee, Palesch, Yuko, Tillman, Holly, Zhao, Wenle, Pauls, Qi, Arnaud, Chris, Dillon, Catherine R, Riley, Jodie, Alford, Teldon, Conner, Cassidy, Coles, Lisa, Sathe, Abhi, Janis, Scott, Hartman, Adam, Fureman, Brandy, Trinka, Eugen, Treiman, David, Wright, David, Ratcliff, Jonathan, Hall, Alex, Williams, Alaina, Simon, Harold, Stanley, Nicholas, Humphries, Roger, Mims, Theresa, Short, Joann, Jones, Elizabeth, Ottman, Misty, Gentile, Nina, Isenberg, Derek, Reimer, Hannah, Kalugdan, Vernon Sayoc, Hemphill, Claude, Madhok, Debbie Yi, Duncan, Jeany, Randazzo, Dominica, Quinn, James, Visweswaran, Anita, Mann, Rosen, Adeoye, Opeolu, McMullan, Jason, Foreman, Brandon, Keegan, Sara, Biros, Michelle, Driver, Brian, Hendrickson, Audrey, Stang, Jamie, Lewandowski, Christopher, Miller, Joseph, Chaudhry, Kaleem, Berry, Shannen, Warden, Craig, Blake, Rachel, Cook, Jennifer NB, Sabolick, Erin, Selman, Antoine, Kissman, Katrina, Moore, Monica, Huff, J Stephen, Becker, Lea, Claassen, Jan, Velazquez, Angela, Falo, Cristina, Coralic, Zlatan, Grupp-Phelan, Jackie, Baren, Jill, Ellison, Angela, Woodford, Ashley, and Samba, Ima
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Neurodegenerative ,Epilepsy ,Clinical Research ,Clinical Trials and Supportive Activities ,Brain Disorders ,Neurosciences ,Pediatric ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adolescent ,Adult ,Age Distribution ,Age Factors ,Aged ,Aged ,80 and over ,Anticonvulsants ,Child ,Child ,Preschool ,Dose-Response Relationship ,Drug ,Double-Blind Method ,Female ,Humans ,Infant ,Levetiracetam ,Male ,Middle Aged ,Phenytoin ,Status Epilepticus ,Valproic Acid ,Young Adult ,Neurological Emergencies Treatment Trials ,Pediatric Emergency Care Applied Research Network investigators ,Medical and Health Sciences ,General & Internal Medicine - Abstract
BackgroundBenzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in children to compare outcomes in three age groups.MethodsIn this multicentre, double-blind, response-adaptive, randomised controlled trial, we recruited patients from 58 hospital emergency departments across the USA. Patients were eligible for inclusion if they were aged 2 years or older, had been treated for a generalised convulsive seizure of longer than 5 min duration with adequate doses of benzodiazepines, and continued to have persistent or recurrent convulsions in the emergency department for at least 5 min and no more than 30 min after the last dose of benzodiazepine. Patients were randomly assigned in a response-adaptive manner, using Bayesian methods and stratified by age group (65 years), to levetiracetam, fosphenytoin, or valproate. All patients, investigators, study staff, and pharmacists were masked to treatment allocation. The primary outcome was absence of clinically apparent seizures with improved consciousness and without additional antiseizure medication at 1 h from start of drug infusion. The primary safety outcome was life-threatening hypotension or cardiac arrhythmia. The efficacy and safety outcomes were analysed by intention to treat. This study is registered in ClinicalTrials.gov, NCT01960075.FindingsBetween Nov 3, 2015, and Dec 29, 2018, we enrolled 478 patients and 462 unique patients were included: 225 children (aged 65 years). 175 (38%) patients were randomly assigned to levetiracetam, 142 (31%) to fosphenyltoin, and 145 (31%) were to valproate. Baseline characteristics were balanced across treatments within age groups. The primary efficacy outcome was met in those treated with levetiracetam for 52% (95% credible interval 41-62) of children, 44% (33-55) of adults, and 37% (19-59) of older adults; with fosphenytoin in 49% (38-61) of children, 46% (34-59) of adults, and 35% (17-59) of older adults; and with valproate in 52% (41-63) of children, 46% (34-58) of adults, and 47% (25-70) of older adults. No differences were detected in efficacy or primary safety outcome by drug within each age group. With the exception of endotracheal intubation in children, secondary safety outcomes did not significantly differ by drug within each age group.InterpretationChildren, adults, and older adults with established status epilepticus respond similarly to levetiracetam, fosphenytoin, and valproate, with treatment success in approximately half of patients. Any of the three drugs can be considered as a potential first-choice, second-line drug for benzodiazepine-refractory status epilepticus.FundingNational Institute of Neurological Disorders and Stroke, National Institutes of Health.
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- 2020
33. Performance Characteristics of Candidate Criteria for Hemodialysis Arteriovenous Fistula Maturation
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Ng, Jia Hwei, Yang, Wei, Dember, Laura M., Feldman, H., Dember, L., Farber, A., Kaufman, J., Stern, L., LeSage, P., Kivork, C., Soares, D., Malikova, M., Allon, M., Young, C., Taylor, M., Woodard, L., Mangadi, K., Roy-Chaudhury, P., Munda, R., Lee, T., Alloway, R., El-Khatib, M., Canaan, T., Pflum, A., Thieken, L., Campos-Naciff, B., Huber, T., Berceli, S., Jansen, M., McCaslin, G., Trahan, Y., Vazquez, M., Vongpatanasin, W., Davidson, I., Hwang, C., Lightfoot, T., Livingston, C., Valencia, A., Dolmatch, B., Fenves, A., Hawkins, N., Cheung, A., Kraiss, L., Kinikini, D., Treiman, G., Ihnat, D., Sarfati, M., Lavasani, I., Maloney, M., Schlotfeldt, L., Himmelfarb, J., Buchanan, C., Clark, C., Crawford, C., Hamlett, J., Kundzins, J., Manahan, L., Wise, J., Beck, G., Gassman, J., Greene, T., Imrey, P., Li, L., Alster, J., Li, M., MacKrell, J., Radeva, M., Weiss, B., Wiggins, K., Alpers, C., Hudkins, K., Wietecha, T., Robbin, M., Umphrey, H., Alexander, L., Abts, C., Belt, L., Vita, J., Hamburg, N., Duess, M., Levit, A., Higgins, H., Ke, S., Mandaci, O., Snell, C., Gravley, J., Behnken, S., Mortensen, R., Chertow, G., Besarab, A., Brayman, K., Diener-West, M., Harrison, D., Inker, L., Louis, T., McClellan, W., Rubin, J., Kusek, J., and Star, R.
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- 2023
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34. Elemental composition of manganese- and phosphorus-rich nodules in the Knockfarril Hill member, Gale crater, Mars
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VanBommel, S.J., Berger, J.A., Gellert, R., O'Connell-Cooper, C.D., McCraig, M.A., Thompson, L.M., Fedo, C.M., Des Marais, D.J., Fey, D.M., Yen, A.S., Clark, B.C., III, Treiman, A.H., and Boyd, N.I.
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- 2023
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35. Number and syllabification of following consonants influence use of long versus short vowels in English disyllables
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Treiman, Rebecca, Kessler, Brett, and Hensley, Kayla
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- 2023
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36. Word Class and Spelling in English
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Treiman, Rebecca, Jewell, Rebecca, Berg, Kristian, and Aronoff, Mark
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The spelling of an English word may reflect its part of speech, not just the sounds within it. In 2 preregistered experiments, we asked whether university students are sensitive to 1 effect of part of speech that has been observed by linguists: that content words (e.g., the noun "inn") must be spelled with at least 3 letters, whereas function words (e.g., the preposition "in") may have only 2 letters. Participants heard VC (vowel-consonant) and consonant-vowel-consonant (CVC; consonant-vowel-consonant) nonwords that were used as nouns (content words) or prepositions (function words). Participants either spelled the items on their own or chose between options with single and double final consonants (e.g., "ib" vs. "ibb"). Participants in the choice task favored final consonant doubling for VCs that were used as nouns. They usually chose single final consonants for VCs that were used as prepositions and for CVCs. Effects of word class were also found in the spelling production task. Final consonant doubling was less common in the production task than the choice task, reflecting participants' reluctance to produce this relatively uncommon spelling pattern. Our results support the view that spelling performance reflects the combined influences of multiple patterns, both phonological and nonphonological.
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- 2021
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37. Encoding of Race Categories by Single Neurons in the Human Brain
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André B. Valdez, Megan H. Papesh, David M. Treiman, Stephen D. Goldinger, and Peter N. Steinmetz
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human single neuron ,hippocampus ,amygdala ,human race perception ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Previous research has suggested that race-specific features are automatically processed during face perception, often with out-group faces treated categorically. Functional imaging has illuminated the hemodynamic correlates of this process, with fewer studies examining single-neuron responses. In the present experiment, epilepsy patients undergoing microwire recordings in preparation for surgical treatment were shown realistic computer-generated human faces, which they classified according to the emotional expression shown. Racial categories of the stimulus faces varied independently of the emotion shown, being irrelevant to the patients’ primary task. Nevertheless, we observed race-driven changes in neural firing rates in the amygdala, anterior cingulate cortex, and hippocampus. These responses were broadly distributed, with the firing rates of 28% of recorded neurons in the amygdala and 45% in the anterior cingulate cortex predicting one or more racial categories. Nearly equal proportions of neurons responded to White and Black faces (24% vs. 22% in the amygdala and 26% vs. 28% in the anterior cingulate cortex). A smaller fraction (12%) of race-responsive neurons in the hippocampus predicted only White faces. Our results imply a distributed representation of race in brain areas involved in affective judgments, decision making, and memory. They also support the hypothesis that race-specific cues are perceptually coded even when those cues are task-irrelevant.
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- 2022
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38. Awareness, perceptions, and choices of physicians pertaining to human papillomavirus (HPV) vaccination in India: A formative research study
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Kataria, Ishu, Siddiqui, Mariam, Treiman, Katherine, Foley, Shaylen, Anand, Meenu, Biswas, Sutapa, Shastri, Digant, Bhatla, Neerja, Radhakrishnan, Diksha, Mamidi, Pavan, and Sankaranarayanan, Rengaswamy
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- 2022
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39. The power of paired proximity science observations: Co-located data from SHERLOC and PIXL on Mars
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Razzell Hollis, Joseph, Moore, Kelsey R., Sharma, Sunanda, Beegle, Luther, Grotzinger, John P., Allwood, Abigail, Abbey, William, Bhartia, Rohit, Brown, Adrian J., Clark, Benton, Cloutis, Edward, Corpolongo, Andrea, Henneke, Jesper, Hickman-Lewis, Keyron, Hurowitz, Joel A., Jones, Michael W.M., Liu, Yang, Martinez-Frías, Jesús, Murphy, Ashley, Pedersen, David A.K., Shkolyar, Svetlana, Siljeström, Sandra, Steele, Andrew, Tice, Mike, Treiman, Alan, Uckert, Kyle, VanBommel, Scott, and Yanchilina, Anastasia
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- 2022
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40. 41 COVID-19 vaccination in cancer patients receiving chemotherapy: does vaccination increase the risk of hypersensitivity reactions?
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Sierra M. Treiman, Katherine Bracamontes, Chelsea Stewart, Bikash Bhattarai, and John Farley
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Gynecology and obstetrics ,RG1-991 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objectives: Hypersensitivity reactions (HSRs) to chemotherapy are one of the leading causes of death due to drug-induced anaphylaxis. Several studies have described HSRs to the various COVID-19 vaccines. This study aims to determine the risk of a HSR among chemotherapy patients who have received the COVID-19 vaccination, by examining if there is a difference in frequency of HSRs to chemotherapeutic agents among patients who have been vaccinated against COVID-19 compared to patients who have not been vaccinated. Methods: This was a retrospective cohort study performed via chart review. Inclusion criteria were all patients receiving any type of chemotherapy at a cancer center between 2018 and 2021. Patients less than 18 years old were excluded. The frequency of patients with one or more episodes of HSRs to chemotherapeutic agents were compared between patients who have received at least one dose of vaccination against COVID-19 to patients who did not receive the vaccination. Incidence proportions of HSRs, relative risk of HSR along with 95% confidence limits, and chi-square based two tailed P-value were reported to compare the differences between the two groups. Results: A total of 1,310 patients were included in the study. There were 531 (41%) patients in the COVID-19 vaccinated group and 778 (59%) in the unvaccinated group. In the vaccinated cohort, the incidence proportion of an HSR after one or more chemotherapy infusions was 1.13%. The incidence proportion in the unvaccinated cohort was 1.03%. Compared to unvaccinated patients, the relative risk of HSR to chemotherapy in vaccinated patients was 1.099 (95% CI = 0.384–3.149). These results indicate that there was a non-significant difference in HSRs between the vaccinated and unvaccinated cohorts (P=0.867). Conclusions: COVID-19 vaccination does not appear to increase the risk of HSRs in chemotherapy recipients. It is essential to continue to ensure the safety and tolerance of COVID-19 vaccines among populations at risk of increased mortality from COVID-19 disease, including cancer patients. This study adds to a body of evidence seeking to analyze and understand potential side effects associated with COVID-19 vaccination. A proposed area of further investigation is to analyze the incidence proportion of HSRs to chemotherapy among patients who have been vaccinated with different types of COVID-19 vaccines.
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- 2023
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41. Preschool Children's Knowledge of Letter Patterns in Print
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Zhang, Lan and Treiman, Rebecca
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According to a statistical-learning view of literacy development, children begin to learn about the visual characteristics of writing from an early age. We used a delayed copying task to examine U.S. preschoolers' knowledge about how letters combine with one another. Children (n = 77, mean age 4 years, 8 months) were shown a series of 4-letter strings for 20 seconds each and were asked to reproduce each string after it had been removed from view. Some strings, such as ‹CHED›, included relatively common combinations of letters. In other strings, such as ‹EHDC›, the letters were rearranged so that the strings looked less like English words. When we scored children's responses for their distance from the presented items, we found better performance on the more wordlike items than the less wordlike items. The results show that preschoolers possess some knowledge about how letters combine, consistent with the statistical-learning view.
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- 2021
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42. Letter Features as Predictors of Letter-Name Acquisition in Four Languages with Three Scripts
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Kim, Young-Suk Grace, Petscher, Yaacov, Treiman, Rebecca, and Kelcey, Benjamin
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To expand our understanding of script-general and script-specific principles in the learning of letter names, we examined how three characteristics of alphabet letters -- their frequency in printed materials, order in the alphabet, and visual similarity to other letters -- relate to children's letter-name knowledge in four languages with three distinct scripts (English [N = 318; M age = 4.90], Portuguese [N = 366; M age = 5.80], Korean [N = 168; M age = 5.48], and Hebrew [N = 645; M age = 5.42]). Explanatory item response modeling analysis showed that the frequency of letters in printed materials was consistently related to letter difficulty across the four languages. There were also moderation effects for letter difficulty in English and Korean, and for discriminatory power of letters in Korean. The results suggest that exposure to letters as measured by letter frequency is a language-general mechanism in the learning of alphabet letters. [For the corresponding grantee submission, see ED609249.]
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- 2021
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43. An experimental study of the alteration of basalt on the surface of Venus
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Teffeteller, H., Filiberto, J., McCanta, M.C., Treiman, A.H., Keller, L., Cherniak, D., Rutherford, M., and Cooper, R.F.
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- 2022
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44. Managing uncertainty and responding to difficult emotions: Cancer patients’ perspectives on clinician response during the COVID-19 pandemic
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Street, Richard L., Jr., Treiman, Katherine, Wu, Qiwei, Kranzler, Elissa C., Moultrie, Rebecca, Mack, Nicole, and Garcia, Reese
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- 2022
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45. Oncology patients’ communication experiences during COVID-19: comparing telehealth consultations to in-person visits
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Street, Jr, Richard L, Treiman, Katherine, Kranzler, Elissa C., Moultrie, Rebecca, Arena, Laura, Mack, Nicole, and Garcia, Reese
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- 2022
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46. Prephonological spelling and its connections with later word reading and spelling performance
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Treiman, Rebecca, Kessler, Brett, and Pollo, Tatiana Cury
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- 2022
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47. Rate of Autoimmune Encephalitis in Children With First-Episode Psychosis.
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Treiman, Geffen, Blackwell, Laura, Howarth, Robyn, and Gombolay, Grace
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- *
VITAMIN B12 deficiency , *ENCEPHALITIS , *CEREBROSPINAL fluid , *ANTI-NMDA receptor encephalitis , *CONFIDENCE intervals , *SYMPTOMS - Abstract
Autoimmune encephalitis (AE) can present as first-episode psychosis (FEP) in children. An FEP diagnostic algorithm has been proposed, but how this algorithm applies to children is unknown. We assess the FEP diagnostic algorithm in children with FEP. The FEP algorithm was applied to a retrospective cohort of children with FEP without other neurological symptoms. Twenty-four patients were included, with five AE (anti- N -methyl-d-aspartate receptor encephalitis) and 19 non-AE patients (12 primary psychiatric, two headaches, mycoplasma-related encephalitis, post–coronavirus disease 2019 encephalitis, drug reaction with eosinophilia and systemic symptoms [DRESS] syndrome, cobalamin C deficiency, and two unknown). Some non-AE patients (five of 19 = 26%) received immunotherapies, with symptom resolution in one of five (20%) with immunotherapy and in four of 14 (29%) without immunotherapy. The FEP algorithm recommended cerebrospinal fluid (CSF) testing in all (five of five = 100%) patients with AE and in six of 19 (32%) non-AE patients, resulting in 100% sensitivity (95% confidence interval [CI]: 100% to 100%) and 45.5% specificity (95% CI: 16% to 75%), with a negative predictive value of 100% (95% CI: 100% to 100%). FEP can occur in children from different causes, including AE and metabolic conditions. Evaluation of FEP should be broad, especially without CSF evidence of inflammation. The FEP algorithm is useful to assess patients who would benefit from CSF testing and should be assessed in larger cohorts. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans.
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Torres-Espin, Abel, Radabaugh, Hannah L., Treiman, Scott, Fitzsimons, Stephen S., Harvey, Danielle, Chou, Austin, Lindbergh, Cutter A., Casaletto, Kaitlin B., Goldberger, Lauren, Staffaroni, Adam M., Maillard, Pauline, Miller, Bruce L., DeCarli, Charles, Hinman, Jason D., Ferguson, Adam R., Kramer, Joel H., and Elahi, Fanny M.
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FIBROBLAST growth factor 2 ,PLACENTAL growth factor ,VASCULAR endothelial growth factors ,VASCULAR endothelial growth factor receptors ,COGNITIVE aging - Abstract
Aberrant angiogenesis could contribute to the development of cognitive impairment and represent a therapeutic target for preventing dementia. However, most studies addressing angiogenesis and cognitive impairment focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in a pooled two-center sample from deeply phenotyped longitudinal human cohorts (n = 435; female = 207, age = 74 ± 9) using cognitive assessments, biospecimens, structural brain imaging, and clinical data. Blood markers included ligands involved in angiogenesis and vascular function such as basic fibroblast growth factor (bFGF), members of the vascular endothelial growth factor family (VEGFA, VEGFB, and VEGFC), and placental growth factor (PlGF), in addition to their receptors VEGF receptor 1 (VEGFR1) and tyrosine kinase with immunoglobulin and EGF homology domain 2 (Tie2). Machine learning and traditional statistics revealed sexually dimorphic associations of plasma angiogenic growth factors with brain aging outcomes, including executive function and gray matter atrophy. Specifically, markers of angiogenesis were associated with higher executive function and less brain atrophy in younger women (not men), a directionality of association that reversed around age 75. Higher concentrations of bFGF, known for pleiotropic effects on multiple cell types, predicted favorable cognitive trajectories in both women and men. An independent sample from a multicenter dataset (MarkVCID; n = 80; female = 30, age = 73 ± 9) was used to externally validate these findings. In conclusion, this analysis demonstrates the association of angiogenesis to human brain aging, with potential therapeutic implications for vascular cognitive impairment and dementia. Editor's summary: Aberrant angiogenesis may contribute to brain aging in humans, but supporting data are limited. Here, Torres-Espin and colleagues applied machine learning and linear mixed effects models to longitudinal data from deeply phenotyped cohorts of aging participants to evaluate the relationships between markers of angiogenesis and structural and functional readouts of brain aging. Concentrations of angiogenesis markers were associated with brain health, with sex-dependent or dimorphic patterns observed, as well as age-dependent directionality. Two principal components were identified, named aberrant angiogenesis and vascular health, and selected angiogenesis markers contributing to these components were noted. These findings, which were broadly validated in a small independent cohort, highlight the association of angiogenesis factors with brain aging and the effects of sex on these interactions, which will need to be explored in future studies. —Melissa L. Norton [ABSTRACT FROM AUTHOR]
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- 2024
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49. Basalt Alteration in a CO2–SO2 Atmosphere: Implications for Surface Processes on Venus.
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Reid, Robert B., McCanta, Molly C., Filiberto, Justin, Treiman, Allan H., Keller, Lindsay, and Rutherford, Malcolm
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VENUSIAN atmosphere ,SCANNING transmission electron microscopy ,ATMOSPHERIC carbon dioxide ,THOLEIITE ,FOCUSED ion beams - Abstract
Venus' surface and interior dynamics remain largely unconstrained, due in great part to the major obstacles to exploration imposed by its 470°C, 90 bar surface conditions and its thick, opaque atmosphere. Flyby and orbiter‐based thermal emission data provide opportunities to characterize the surface composition of Venus. However, robust interpretations of such data depend on understanding interactions between the planet's surface basaltic rocks and its caustic carbon dioxide (CO2)‐dominant atmosphere, containing trace amounts of sulfur dioxide (SO2). Several studies, using remote sensing, thermodynamic modeling, and laboratory experiments, have placed constraints on basaltic alteration mineralogy and rates. However, constraints on the effects of SO2‐bearing reactions on basalts with diverse compositions remain incomplete. Here, we present new data from a series of gas‐solid reaction experiments, in which samples of two basalt compositions were reacted in an SO2‐bearing CO2 atmosphere, at relevant Venus temperatures, pressure, and oxygen fugacity. Reacted specimens were analyzed by scanning electron microscopy and scanning transmission electron microscopy using sample cross‐sections produced with focused ion beam milling. Surface alteration products were characterized, and their abundances estimated; subsurface cation concentrations were mapped to show the depth of alteration. We demonstrate that the initial development of reaction products progresses rapidly over the course of 30‐day runs. Alkaline basalt samples are coated by Na‐sulfate (likely thenardite, Na2SO4) and amorphous calcium carbonate (CaCO3) alteration products, and tholeiitic basalt samples are primarily covered by anhydrite (CaSO4), Fe‐oxide (FexOy: likely magnetite, Fe3O4), and other minor phases. These mineralogies differ from previous experiments in CO2‐only atmospheres. Plain Language Summary: Surface features on Venus, such as volcanic landforms, and their ages can be studied to infer the planet's interior properties. Venus' thick, opaque atmosphere and extreme temperature and pressure limit a detailed study of its surface. Fortunately, sensors aboard Venus‐orbiting spacecraft can "see" its surface using select wavelengths of light to provide opportunities to interpret the composition of its surface. However, these interpretations rely on understanding how Venus' atmosphere might chemically interact with the surface and what mineral products may result. This is not yet fully understood despite the results of several prior studies with objectives similar to ours. Here, we share the results from experiments that mimic these chemical reactions. We used rock types such as those known to be on the surface of Venus and subjected them to relevant temperatures and pressure and a blend of two reactive gases, carbon dioxide and sulfur dioxide, to model Venus' atmosphere. After the experiments, we examined the rocks with microscopic instruments that allowed us to characterize chemical changes from their surfaces to their interiors. Our interpretations suggest that these reactions occur rapidly and that the compositions of the mineral coatings produced are dictated by the rocks' slightly different compositions. Key Points: Basalts experimentally altered under Venus P‐T conditions and a CO2–SO2 atmosphere produce reaction products of Ca‐ and Na‐sulfates, and Fe‐oxidesAlteration products and the advancement of alteration were strongly dependent upon the compositions of the solid reactantsThe rates at which basalts altered in a CO2–SO2 atmosphere were greater than rates in a CO2‐only atmosphere [ABSTRACT FROM AUTHOR]
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- 2024
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50. Learning to Spell Phonologically: Influences of Children's Own Names
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Zhang, Lan and Treiman, Rebecca
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Young spellers must learn to symbolize the sounds in words with phonologically appropriate letters. Do children use their knowledge about their own names to do this, performing better on sound--letter correspondences in their name than expected on the basis of other factors? According to some theories, children learn the spelling of their name as a rote form and do not derive conceptual knowledge from the name that transfers to other items. Analyzing data from studies in which 565 U.S. 3- to 6-year-old children spelled words or nonwords, however, we found that children who had begun to represent some sounds in their spelling used the initial sound-letter correspondence of their first name in an appropriate manner more often than otherwise expected. The results shed new light on the role of personal names in spelling development and have implications for early literacy instruction and assessment.
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- 2020
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