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2. Albuminuria Testing in Hypertension and Diabetes: An Individual-Participant Data Meta-Analysis in a Global Consortium.

Author

Shin, Jung-Im, Chang, Alex, Grams, Morgan, Coresh, Josef, Ballew, Shoshana, Surapaneni, Aditya, Matsushita, Kunihiro, Bilo, Henk, Carrero, Juan, Chodick, Gabriel, Daratha, Kenn, Jassal, Simerjot, Nadkarni, Girish, Nelson, Robert, Nowak, Christoph, Stempniewicz, Nikita, Sumida, Keiichi, Traynor, Jamie, Woodward, Mark, Sang, Yingying, and Gansevoort, Ron

Subjects
albuminuria, blood pressure, diabetes mellitus, hypertension, kidney, prevalence risk, Adult, Aged, Albuminuria, Creatinine, Diabetes Mellitus, Glomerular Filtration Rate, Humans, Hypertension, Middle Aged, Renal Insufficiency, Chronic
Abstract

[Figure: see text].

Published
2021

4. Outcomes in ANCA-Associated Vasculitis in Scotland: Validation of the Renal Risk Score in a Complete National Cohort

Author

McGovern, Dominic P., Lees, Jennifer S., Traynor, Jamie P., Mackinnon, Bruce, Bell, Samira, Hunter, Robert W., Dhaun, Neeraj, Metcalfe, Wendy, Kidder, Dana, Lim, Michelle, Joss, Nicola, Kelly, Michael, Taylor, Alison, Cousland, Zoe, Dey, Vishal, Buck, Kate, Brix, Silke, Geddes, Colin C., McQuarrie, Emily P., and Stevens, Kathryn I.

Published
2023
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5. Evans M, Grams ME, Sang Y, et al., for the Chronic Kidney Disease Prognosis Consortium. Risk factors for prognosis in patients with severely decreased GFR. Kidney Int Rep. 2018;3:625–637

Author

Astor, Brad, Appel, Lawrence J, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Navaneethan, Sankar D, Jolly, Stacey E, Schold, Jesse D, Nally, Joseph V, Wheeler, David C, Emberson, Jonathan, Townend, John, Landray, Martin, Feldman, Harold I, Hsu, Chi-yuan, Lash, James P, Kalra, Philip A, Ritchie, James P, Maharajan, Raman, Alderson, Helen, Lane, Beverly, Eckardt, Kai-Uwe, Schneider, Markus P, Köttgen, Anna, Kronenberg, Florian, Bärthlein, Barbara, Chang, Alex R, Green, Jamie A, Kirchner, H Lester, Ho, Kevin, Marks, Angharad, Black, Corri, Prescott, Gordon J, Fluck, Nick, Nakayama, Masaaki, Miyazaki, Mariko, Yamamoto, Tae, Yamada, Wang, Angela Yee-Moon, Cheung, Sharon, Wong, Sharon, Chu, Jessie, Wu, Henry, Shalev, Varda, Chodick, Gabriel, Blankestijn, Peter J, Wetzels, Jack FM, van Zuilen, Arjan D, van den Brand, Jan A, Levey, Andrew S, Inker, Lesley A, Sarnak, Mark J, Tighiouart, Hocine, Zhang, Haitao, Stengel, Benedicte, Rios, Pablo G, Mazzuchi, Nelson, Gadola, Liliana, Lamadrid, Verónica, Sola, Laura, Collins, John F, Elley, C Raina, Kenealy, Timothy, Moranne, Olivier, Couchoud, Cecile, Vigneau, Cecile, Brunskill, Nigel J, Major, Rupert W, Shepherd, David, Medcalf, James F, Kovesdy, Csaba P, Kalantar-Zadeh, Kamyar, Molnar, Miklos Z, Sumida, Keiichi, Potukuchi, Praveen K, Heerspink, Hiddo JL, de Zeeuw, Dick, Brenner, Barry, Carrero, Juan Jesus, Barany, Peter, Qureshi, Abdul Rashid, Elinder, Carl-Gustaf, Visseren, Frank LJ, van der Graaf, Yolanda, Evans, Marie, Stendahl, Maria, Schön, Staffan, Segelmark, Mårten, Prütz, Karl-Göran, Naimark, David M, Tangri, Navdeep, Mark, Patrick B, Traynor, Jamie P, Geddes, Colin C, Thomson, Peter C, and Coresh, Josef

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Renal and urogenital, Good Health and Well Being, Chronic Kidney Disease Prognosis Consortium, Biomedical and clinical sciences, Health sciences
Abstract

[This corrects the article DOI: 10.1016/j.ekir.2018.01.002.].

Published
2018

7. Low circulating miR-190a-5p predicts progression of chronic kidney disease.

Author

Baird, David P, primary, Zang, Jinnan, additional, Connor, Katie L, additional, Teenan, Oliver, additional, Wong, Ryan K Y, additional, Reck, Maximilian, additional, Cairns, Carolynn, additional, Traynor, Jamie P, additional, Hughes, Jeremy, additional, Mark, Patrick B, additional, Maxwell, Alexander P, additional, McKay, Gareth J, additional, Simpson, David A., additional, Denby, Laura, additional, and Conway, Bryan R, additional

Published
2024
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8. Urinary Clusterin is a biomarker of renal epithelial senescence and predicts human kidney disease progression

Author

Baird, David, primary, Reck, Maximillian, additional, Campbell, Ross, additional, Docherty, Marie-Helena, additional, Vermeren, Matthieu, additional, Nam, Andy, additional, Yang, Wei, additional, Schurman, Nathan, additional, Williams, Claire, additional, Traynor, Jamie P., additional, Mark, Patrick B., additional, Mylonas, Katie, additional, Hughes, Jeremy, additional, Denby, Laura, additional, Conway, Bryan, additional, and Ferenbach, David A, additional

Published
2024
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9. Data from the ERA-EDTA Registry were examined for trends in excess mortality in European adults on kidney replacement therapy

Author

Boenink, Rianne, Stel, Vianda S., Waldum-Grevbo, Bård E., Collart, Frederic, Kerschbaum, Julia, Heaf, James G., de Meester, Johan, Finne, Patrik, García-Marcos, Sergio A., Evans, Marie, Ambühl, Patrice M., Arici, Mustafa, Ayav, Carole, Steenkamp, Retha, Cases, Aleix, Traynor, Jamie P., Palsson, Runolfur, Zoccali, Carmine, Massy, Ziad A., Jager, Kitty J., and Kramer, Anneke

Published
2020
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11. Long-term all-cause mortality and cardiovascular outcomes in Scottish children after initiation of renal replacement therapy: a national cohort study

Author

Galiyeva, Dinara B., Jackson, Caroline A., Wild, Sarah H., Burns, Susan, Hughes, David, Traynor, Jamie P., Metcalfe, Wendy, and Halbesma, Nynke

Subjects
Chronic kidney failure -- Care and treatment -- Complications and side effects -- Patient outcomes, Cardiovascular diseases -- Risk factors -- Patient outcomes, Pediatric research, Health
Abstract

Background Data on long-term outcomes in children who have received renal replacement therapy (RRT) for end-stage renal disease are limited. Methods We studied long-term survival and incidence of fatal and nonfatal cardiovascular disease (CVD) events and determinants of these outcomes in children who initiated RRT between 1961 and 2013 using data from the Scottish Renal Registry (SRR). Linkage to morbidity records was available from 1981. Results A total of 477 children of whom 55% were boys, almost 50% had congenital urinary tract disease (CAKUT), 10% received a transplant as the first mode of RRT and almost 60% were over 11 years of age at start of RRT were followed for a median of 17.8 years (interquartile range (IQR) 8.7-26.6 years). Survival was 87.3% (95% confidence interval (CI) 84.0-90.1) at 10 years and 77.6% (95% CI 73.3-81.7) at 20 years. During a median follow-up of 14.96 years (IQR 7.1-22.9), 20.9% of the 381 patients with morbidity data available had an incident of CVD event. Age < 2 years at start of RRT, receiving dialysis rather than a kidney transplant and primary renal disease (PRD) other than CAKUT or glomerulonephritis (GN), were associated with a higher risk of all-cause mortality. Male sex, receiving dialysis rather than a kidney transplant and PRD other than CAKUT or GN, was associated with a higher risk of CVD incidence. Conclusions Mortality and CVD incidence among children receiving RRT are high. PRD and RRT modality were associated with increased risk of both all-cause mortality and CVD incidence., Author(s): Dinara B. Galiyeva [sup.1] , Caroline A. Jackson [sup.1] , Sarah H. Wild [sup.1] , Susan Burns [sup.2] , David Hughes [sup.2] , Jamie P. Traynor [sup.3] , Wendy [...]

Published
2020
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12. The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

Author

Stapleton, Caragh P., Heinzel, Andreas, Guan, Weihua, van der Most, Peter J., van Setten, Jessica, Lord, Graham M., Keating, Brendan J., Israni, Ajay K., de Borst, Martin H., Bakker, Stephan J.L., Snieder, Harold, Weale, Michael E., Delaney, Florence, Hernandez-Fuentes, Maria P., Reindl-Schwaighofer, Roman, Oberbauer, Rainer, Jacobson, Pamala A., Mark, Patrick B., Chapman, Fiona A., Phelan, Paul J., Kennedy, Claire, Sexton, Donal, Murray, Susan, Jardine, Alan, Traynor, Jamie P., McKnight, Amy Jayne, Maxwell, Alexander P., Smyth, Laura J., Oetting, William S., Matas, Arthur J., Mannon, Roslyn B., Schladt, David P., Iklé, David N., Cavalleri, Gianpiero L., and Conlon, Peter J.

Published
2019
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17. Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity: an analysis of data from the ERA-EDTA Registry

Author

Koopman, Jacob J.E., Kramer, Anneke, van Heemst, Diana, Åsberg, Anders, Beuscart, Jean-Baptiste, Buturović-Ponikvar, Jadranka, Collart, Frederic, Couchoud, Cécile G., Finne, Patrik, Heaf, James G., Massy, Ziad A., De Meester, Johan M.J., Palsson, Runolfur, Steenkamp, Retha, Traynor, Jamie P., Jager, Kitty J., and Putter, Hein

Published
2016
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18. The Kidney Failure Risk Equation: Evaluation of Novel Input Variables including eGFR Estimated Using the CKD-EPI 2021 Equation in 59 Cohorts

Author

Grams, Morgan E., primary, Brunskill, Nigel J., additional, Ballew, Shoshana H., additional, Sang, Yingying, additional, Coresh, Josef, additional, Matsushita, Kunihiro, additional, Surapaneni, Aditya, additional, Bell, Samira, additional, Carrero, Juan J., additional, Chodick, Gabriel, additional, Evans, Marie, additional, Heerspink, Hiddo J.L., additional, Inker, Lesley A., additional, Iseki, Kunitoshi, additional, Kalra, Philip A., additional, Kirchner, H. Lester, additional, Lee, Brian J., additional, Levin, Adeera, additional, Major, Rupert W., additional, Medcalf, James, additional, Nadkarni, Girish N., additional, Naimark, David M.J., additional, Ricardo, Ana C., additional, Sawhney, Simon, additional, Sood, Manish M., additional, Staplin, Natalie, additional, Stempniewicz, Nikita, additional, Stengel, Benedicte, additional, Sumida, Keiichi, additional, Traynor, Jamie P., additional, van den Brand, Jan, additional, Wen, Chi-Pang, additional, Woodward, Mark, additional, Yang, Jae Won, additional, Wang, Angela Yee-Moon, additional, and Tangri, Navdeep, additional

Published
2023
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20. Development and validation of prediction models of adverse kidney outcomes in the population with and without diabetes mellitus

Author

Grams, Morgan E, primary, Brunskill, Nigel J, primary, Ballew, Shoshana H, primary, Sang, Yingying, primary, Coresh, Josef, primary, Matsushita, Kunihiro, primary, Surapaneni, Aditya, primary, Bell, Samira, primary, Carrero, Juan J, primary, Chodick, Gabriel, primary, Evans, Marie, primary, Heerspink, Hiddo JL, primary, Inker, Lesley A, primary, Iseki, Kunitoshi, primary, Kalra, Philip A, primary, Kirchner, H Lester, primary, Lee, Brian J, primary, Levin, Adeera, primary, Major, Rupert W, primary, Medcalf, James, primary, Nadkarni, Girish N, primary, Naimark, David MJ, primary, Ricardo, Ana C, primary, Sawhney, Simon, primary, Sood, Manish M, primary, Staplin, Natalie, primary, Stempniewicz, Nikita, primary, Stengel, Benedicte, primary, Sumida, Keiichi, primary, Traynor, Jamie P, primary, Brand, Jan van den, primary, Wen, Chi-Pang, primary, Woodward, Mark, primary, Yang, Jae Won, primary, Wang, Angela Yee-Moon, primary, Tangri, Navdeep, primary, and Consortium, the CKD Prognosis, primary

Published
2022
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21. The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland

Author

Bell, Samira, primary, Campbell, Jacqueline, additional, Lambourg, Emilie, additional, Watters, Chrissie, additional, O’Neil, Martin, additional, Almond, Alison, additional, Buck, Katharine, additional, Carr, Edward J., additional, Clark, Laura, additional, Cousland, Zoe, additional, Findlay, Mark, additional, Joss, Nicola, additional, Metcalfe, Wendy, additional, Petrie, Michaela, additional, Spalding, Elaine, additional, Traynor, Jamie P., additional, Sanu, Vinod, additional, Thomson, Peter, additional, Methven, Shona, additional, and Mark, Patrick B., additional

Published
2022
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25. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort.

Author

Mayne, Kaitlin J, Lees, Jennifer S, Rutherford, Elaine, Thomson, Peter C, Traynor, Jamie P, Dey, Vishal, Lang, Ninian N, and Mark, Patrick B

Subjects
PLATELET lymphocyte ratio, NEUTROPHIL lymphocyte ratio, HEMODIALYSIS, COVID-19, HEMODIALYSIS patients
Abstract

Background Lymphocyte ratios reflect inflammation and have been associated with adverse outcomes in a range of diseases. We sought to determine any association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality in a haemodialysis cohort, including a coronavirus disease 2019 (COVID-19) infection subpopulation. Methods A retrospective analysis was performed of adults commencing hospital haemodialysis in the West of Scotland during 2010–21. NLR and PLR were calculated from routine samples around haemodialysis initiation. Kaplan–Meier and Cox proportional hazards analyses were used to assess mortality associations. Results In 1720 haemodialysis patients over a median of 21.9 (interquartile range 9.1–42.9) months, there were 840 all-cause deaths. NLR but not PLR was associated with all-cause mortality after multivariable adjustment [adjusted hazard ratio (aHR) for in participants with baseline NLR in quartile 4 (NLR ≥8.23) versus quartile 1 (NLR <3.12) 1.63, 95% confidence interval (CI) 1.32–2.00]. The association was stronger for cardiovascular death (NLR quartile 4 versus 1 aHR 3.06, 95% CI 1.53–6.09) than for non-cardiovascular death (NLR quartile 4 versus 1 aHR 1.85, 95% CI 1.34–2.56). In the COVID-19 subpopulation, both NLR and PLR at haemodialysis initiation were associated with risk of COVID-19-related death after adjustment for age and sex (NLR: aHR 4.69, 95% CI 1.48–14.92 and PLR: aHR 3.40, 95% CI 1.02–11.36; for highest vs lowest quartiles). Conclusions NLR is strongly associated with mortality in haemodialysis patients while the association between PLR and adverse outcomes is weaker. NLR is an inexpensive, readily available biomarker with potential utility in risk stratification of haemodialysis patients. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Incidence and Outcomes of Patients Receiving Chronic Kidney Replacement Therapy Admitted to Scottish ICUs Between 2009 and 2019-A National Observational Cohort Study.

Author

Lambourg, Emilie, Walker, Heather, Campbell, Jacqueline, Watters, Chrissie, O'Neil, Martin, Donaldson, Lorraine, Siddiqui, Moneeza K., Almond, Alison, Buck, Katharine, Cousland, Zoe, Joss, Nicola, Metcalfe, Wendy, Methven, Shona, Sanu, Vinod, Spalding, Elaine, Traynor, Jamie P., Lone, Nazir I, Bell, Samira, and Scottish Renal Registry

Published
2023
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27. Short- and long-term outcomes of intensive care patients with acute kidney disease

Author

Andonovic, Mark, Traynor, Jamie P., Shaw, Martin, Sim, Malcolm A.B., Mark, Patrick B., and Puxty, Kathryn A.

Subjects
Medicine (General), R5-920, Acute kidney disease, Intensive care, Long-term outcomes, General Medicine
Abstract

Background:\ud Acute kidney disease (AKD) is a proposed definition for acute kidney injury (AKI) lasting 7 days or longer. Little has been reported regarding characteristics of patients with AKD and their short- and long-term outcomes. We describe the epidemiology and risk factors for AKD and outcomes following AKD.\ud \ud Methods:\ud This retrospective observational cohort study identified patients aged 16 or older admitted to the Glasgow Royal Infirmary and Queen Elizabeth University Hospital intensive care units (ICUs) in Scotland between 1st July 2015 and 30th June 2018. Baseline serum creatinine and subsequent values were used to identify patients with de-novo kidney injury (DNKI). Patients with recovery prior to day 7 were classified as AKI; recovery at day 7 or beyond was classified as AKD. Outcomes were in-hospital and long-term mortality, and proportion of major adverse kidney events (MAKEs). Multivariable logistic regression was used to identify risk factors for AKD. A Cox proportional hazards model was used to identify factors associated with long-term outcomes.\ud \ud Findings:\ud Of the 5,334 patients admitted to ICU who were assessed for DNKI, 1,620 (30·4%) suffered DNKI and of these, 403 (24·9%) met AKD criteria; 984 (60·7%) were male and the median age was 60·0 (IQR=48·0–72·0). Male sex, sepsis and lower baseline estimated glomerular filtration rate (eGFR) were associated with development of AKD. In-ICU (16·1%vs6·2%) and in-hospital (26·1%vs11·6%) mortality rates were significantly higher in AKD patients than AKI patients. Long-term survival was not different for AKD patients (HR=1·16; p-value=0·261) but AKD was associated with subsequent MAKEs (OR=1·25).\ud \ud Interpretation:\ud One in four ICU patients with DNKI met AKD criteria. These patients had an increased risk of short-term mortality and long-term MAKEs. Whilst the trend for long-term survival was lower, this was not significantly different from shorter-term AKI patients. Patients with AKD during their ICU stay should be identified to initiate interventions to reduce risk of future MAKEs.\ud \ud Funding:\ud No funding was associated with this study.

Published
2021

29. Incidence of Kidney Replacement Therapy and Subsequent Outcomes Among Patients With Systemic Lupus Erythematosus: Findings From the ERA Registry

Author

Derner, Ondrej, primary, Kramer, Anneke, additional, Hruskova, Zdenka, additional, Arici, Mustafa, additional, Collart, Frederic, additional, Finne, Patrik, additional, Fuentes Sánchez, Laura, additional, Harambat, Jérôme, additional, Hemmelder, Marc H., additional, Hommel, Kristine, additional, Kerschbaum, Julia, additional, De Meester, Johan, additional, Palsson, Runolfur, additional, Segelmark, Mårten, additional, Skrunes, Rannveig, additional, Traynor, Jamie P., additional, Zurriaga, Oscar, additional, Massy, Ziad A., additional, Jager, Kitty J., additional, Stel, Vianda S., additional, and Tesar, Vladimir, additional

Published
2021
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30. Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - A high risk community-hospital interface

Author

Li, Kathy K, Woo, Y Mun, Stirrup, Oliver, Hughes, Joseph, Ho, Antonia, Filipe, Ana Da Silva, Johnson, Natasha, Smollett, Katherine, Mair, Daniel, Carmichael, Stephen, Tong, Lily, Nichols, Jenna, Aranday-Cortes, Elihu, Brunker, Kirstyn, Parr, Yasmin A, Nomikou, Kyriaki, McDonald, Sarah E, Niebel, Marc, Asamaphan, Patawee, Sreenu, Vattipally B, Robertson, David L, Taggart, Aislynn, Jesudason, Natasha, Shah, Rajiv, Shepherd, James, Singer, Josh, Taylor, Alison HM, Cousland, Zoe, Price, Jonathan, Lees, Jennifer S, Jones, Timothy PW, Lopez, Carlos Varon, MacLean, Alasdair, Starinskij, Igor, Gunson, Rory, Morris, Scott TW, Thomson, Peter C, Geddes, Colin C, Traynor, Jamie P, Breuer, Judith, Thomson, Emma C, Mark, Patrick B, and COVID-19 Genomics UK (COG-UK) consortium

Subjects
fungi
Abstract

OBJECTIVES: Patients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium. METHODS: We combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations. RESULTS: Of 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated. CONCLUSIONS: Near-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.

Published
2021

31. Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease

Author

O’Sullivan, Eoin D., Lees, Jennifer S., Howie, Katie L., Pugh, Dan, Gillis, Keith A., Traynor, Jamie P., Macintyre, Iain, and Mark, Patrick B.

Abstract

Recent World Health Organization guidance has aimed to provide pragmatic guidance acknowledging the role of sequential nasopharyngeal swabs taken >24 hours apart for SARS‐CoV‐2 in high‐risk populations. Patients with chronic kidney disease (CKD) are known to have an altered immune milieu which may be associated with a delay in viral clearance. Here, a cross‐sectional observational study of 138 patients admitted with SARS‐CoV‐2 infection at two large regional hospitals in Scotland, UK examined the median time to two consecutive negative nasopharyngeal swabs for SARS‐CoV‐2 in an inpatient population. The median time from admission to the first of two consecutive negative nasopharyngeal swabs was 18 days (range = 1‐44) in patients with CKD, compared with 11 days (range: 1‐71) in patients without CKD (P = .0007). Multivariable linear regression analysis using explanatory variables of age, sex, SARS‐CoV‐2 disease severity, key comorbidities and renal function showed that declining estimated glomerular filtration rate was independently associated with prolonged time to viral clearance. Our data suggest that patients with CKD who are admitted to hospital with SARS‐CoV‐2 take longer to achieve sequential negative nasopharyngeal swab reverse transcription‐polymerase chain reaction results than those without CKD. This has implications for renal service provision, discharge planning and hospital capacity as well as a direct impact on patients due to extended hospital stay, anxiety and stigmatisation.

Published
2021

33. ANCA-associated renal vasculitis is associated with rurality but not seasonality or deprivation in a complete national cohort study

Author

Aiyegbusi, Oshorenua, primary, Frleta-Gilchrist, Marina, additional, Traynor, Jamie P, additional, Mackinnon, Bruce, additional, Bell, Samira, additional, Hunter, Robert W, additional, Dhaun, Neeraj, additional, Kidder, Dana, additional, Stewart, Graham, additional, Joss, Nicola, additional, Kelly, Michael, additional, Shah, Shahzad, additional, Dey, Vishal, additional, Buck, Kate, additional, Stevens, Kathryn I, additional, Geddes, Colin C, additional, and McQuarrie, Emily P, additional

Published
2021
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34. Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial

Author

Witham, Miles D., Lees, Jennifer S., White, Myra, Band, Margaret, Bell, Samira, Chantler, Donna J., Ford, Ian, Fulton, Roberta L., Kennedy, Gwen, Littleford, Roberta C., McCrea, Ian V., McGlynn, Deborah, Panarelli, Maurizio, Ralston, Maximilian R., Rutherford, Elaine, Severn, Alison, Thomson, Nicola, Traynor, Jamie P., Struthers, Allan D., Wetherall, Kirsty, and Mark, Patrick B.

Abstract

BACKGROUND:Vascular calcification, a risk factor for cardiovascular disease, is common among patients with CKD and is an independent contributor to increased vascular stiffness and vascular risk in this patient group. Vitamin K is a cofactor for proteins involved in prevention of vascular calcification. Whether or not vitamin K supplementation could improve arterial stiffness in patients with CKD is unknown. METHODS:To determine if vitamin K supplementation might improve arterial stiffness in patients in CKD, we conducted a parallel-group, double-blind, randomized trial in participants aged 18 or older with CKD stage 3b or 4 (eGFR 15-45 ml/min per 1.73 m2). We randomly assigned participants to receive 400 μg oral vitamin K2 or matching placebo once daily for a year. The primary outcome was the adjusted between-group difference in carotid-femoral pulse wave velocity at 12 months. Secondary outcomes included augmentation index, abdominal aortic calcification, BP, physical function, and blood markers of mineral metabolism and vascular health. We also updated a recently published meta-analysis of trials to include the findings of this study. RESULTS:We included 159 randomized participants in the modified intention-to-treat analysis, with 80 allocated to receive vitamin K and 79 to receive placebo. Mean age was 66 years, 62 (39%) were female, and 87 (55%) had CKD stage 4. We found no differences in pulse wave velocity at 12 months, augmentation index at 12 months, BP, B-type natriuretic peptide, or physical function. The updated meta-analysis showed no effect of vitamin K supplementation on vascular stiffness or vascular calcification measures. CONCLUSIONS:Vitamin K2 supplementation did not improve vascular stiffness or other measures of vascular health in this trial involving individuals with CKD. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER:Vitamin K therapy to improve vascular health in patients with chronic kidney disease, ISRCTN21444964 (www.isrctn.com).

Published
2020

36. INC901688 Supplemental Material1 - Supplemental material for Timing of renal replacement therapy for patients with acute kidney injury: A systematic review and meta-analysis

Author

Andonovic, Mark, Shemilt, Richard, Sim, Malcolm, Traynor, Jamie P, Shaw, Martin, Mark, Patrick B, and Puxty, Kathryn A

Subjects
111708 Health and Community Services, FOS: Clinical medicine, Cardiology, 110323 Surgery, FOS: Health sciences, 110305 Emergency Medicine, humanities
Abstract

Supplemental material, INC901688 Supplemental Material1 for Timing of renal replacement therapy for patients with acute kidney injury: A systematic review and meta-analysis by Mark Andonovic, Richard Shemilt, Malcolm Sim, Jamie P Traynor, Martin Shaw, Patrick B Mark and Kathryn A Puxty in Journal of the Intensive Care Society

Published
2020
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37. Additional file 1 of The relative importance of frailty, physical and cardiovascular function as exercise-modifiable predictors of falls in haemodialysis patients: a prospective cohort study

Author

Zanotto, Tobia, Mercer, Thomas H., Linden, Marietta L. Van Der, Rush, Robert, Traynor, Jamie P., Petrie, Colin J., Doyle, Arthur, Chalmers, Karen, Allan, Nicola, Shilliday, Ilona, and Koufaki, Pelagia

Abstract

Additional file 1: Table S1. Multicollinearity analysis: correlations among baroreflex function variables; Table S2. Negative binomial regression analysis: sensitivity analyses.

Published
2020
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38. The ERA-EDTA Registry Annual Report 2017

Author

Kramer, Anneke, Boenink, Rianne, Noordzij, Marlies, Bosdriesz, Jizzo R., Stel, Vianda S., Beltrán, Palma, Ruiz, Juan C., Seyahi, Nurhan, Comas Farnés, Jordi, Stendahl, Maria, Garneata, Liliana, Winzeler, Rebecca, Golan, Eliezer, Lopot, František, Korejwo, Grzegorz, Bonthuis, Marjolein, Lassalle, Mathilde, Slon Roblero, María F., Kuzema, Viktorija, Hommel, Kristine, Stojceva-Taneva, Olivera, Åsberg, Anders, Kramar, Reinhard, Hemmelder, Marc H., de Meester, Johan, Vazelov, Evgueniy, Andrusev, Anton M., Castro de la Nuez, Pablo, Helve, Jaakko, Komissarov, Kirill, Casula, Anna, Magaz, Ángela, Santiuste de Pablos, Carmen, Bubic, Ivan, Traynor, Jamie P., Ioannou, Kyriakos, Idrizi, Alma, Palsson, Runolfur, des Grottes, Jean-Marin, Spustova, Viera, Tolaj-Avdiu, Miloreta, Nordio, Maurizio, Ziginskiene, Edita, Massy, Ziad A., Jager, Kitty J., APH - Quality of Care, APH - Aging & Later Life, ACS - Pulmonary hypertension & thrombosis, Medical Informatics, Graduate School, Infectious diseases, APH - Methodology, APH - Health Behaviors & Chronic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, and APH - Global Health

Published
2020

43. Reply

Author

Methven, Shona, MacGregor, Mark S., Traynor, Jamie P., O’Reilly, Denis St J., and Deighan, Christopher J.

Published
2011
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45. Conversion of Urine Protein–Creatinine Ratio or Urine Dipstick Protein to Urine Albumin–Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis

Author

Sumida, Keiichi, primary, Nadkarni, Girish N., additional, Grams, Morgan E., additional, Sang, Yingying, additional, Ballew, Shoshana H., additional, Coresh, Josef, additional, Matsushita, Kunihiro, additional, Surapaneni, Aditya, additional, Brunskill, Nigel, additional, Chadban, Steve J., additional, Chang, Alex R., additional, Cirillo, Massimo, additional, Daratha, Kenn B., additional, Gansevoort, Ron T., additional, Garg, Amit X., additional, Iacoviello, Licia, additional, Kayama, Takamasa, additional, Konta, Tsuneo, additional, Kovesdy, Csaba P., additional, Lash, James, additional, Lee, Brian J., additional, Major, Rupert W., additional, Metzger, Marie, additional, Miura, Katsuyuki, additional, Naimark, David M.J., additional, Nelson, Robert G., additional, Sawhney, Simon, additional, Stempniewicz, Nikita, additional, Tang, Mila, additional, Townsend, Raymond R., additional, Traynor, Jamie P., additional, Valdivielso, José M., additional, Wetzels, Jack, additional, Polkinghorne, Kevan R., additional, and Heerspink, Hiddo J.L., additional

Published
2020
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46. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial

Author

Witham, Miles D., primary, Lees, Jennifer S., additional, White, Myra, additional, Band, Margaret, additional, Bell, Samira, additional, Chantler, Donna J., additional, Ford, Ian, additional, Fulton, Roberta L., additional, Kennedy, Gwen, additional, Littleford, Roberta C., additional, McCrea, Ian V., additional, McGlynn, Deborah, additional, Panarelli, Maurizio, additional, Ralston, Maximilian R., additional, Rutherford, Elaine, additional, Severn, Alison, additional, Thomson, Nicola, additional, Traynor, Jamie P., additional, Struthers, Allan D., additional, Wetherall, Kirsty, additional, and Mark, Patrick B., additional

Published
2020
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47. COVID-19 in patients undergoing renal replacement therapy in Scotland: findings and experience from the Scottish Renal Registry

Author

Bell, Samira, primary, Campbell, Jacqueline, additional, McDonald, Jackie, additional, O’Neill, Martin, additional, Watters, Chrissie, additional, Buck, Katharine, additional, Cousland, Zoe, additional, Findlay, Mark, additional, Lone, Nazir I, additional, Metcalfe, Wendy, additional, Methven, Shona, additional, Peel, Robert, additional, Almond, Alison, additional, Sanu, Vinod, additional, Spalding, Elaine, additional, Thomson, Peter C, additional, Mark, Patrick B, additional, and Traynor, Jamie P, additional

Published
2020
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48. The ERA-EDTA Registry Annual Report 2017: a summary

Author

Kramer, Anneke, primary, Boenink, Rianne, additional, Noordzij, Marlies, additional, Bosdriesz, Jizzo R, additional, Stel, Vianda S, additional, Beltrán, Palma, additional, Ruiz, Juan C, additional, Seyahi, Nurhan, additional, Comas Farnés, Jordi, additional, Stendahl, Maria, additional, Garneata, Liliana, additional, Winzeler, Rebecca, additional, Golan, Eliezer, additional, Lopot, František, additional, Korejwo, Grzegorz, additional, Bonthuis, Marjolein, additional, Lassalle, Mathilde, additional, Slon Roblero, Maria F, additional, Kuzema, Viktorija, additional, Hommel, Kristine, additional, Stojceva-Taneva, Olivera, additional, Asberg, Anders, additional, Kramar, Reinhard, additional, Hemmelder, Marc H, additional, De Meester, Johan, additional, Vazelov, Evgueniy, additional, Andrusev, Anton, additional, Castro de la Nuez, Pablo, additional, Helve, Jaakko, additional, Komissarov, Kirill, additional, Casula, Anna, additional, Magaz, Ángela, additional, Santiuste de Pablos, Carmen, additional, Bubić, Ivan, additional, Traynor, Jamie P, additional, Ioannou, Kyriakos, additional, Idrizi, Alma, additional, Palsson, Runolfur, additional, des Grottes, Jean-Marin, additional, Spustova, Viera, additional, Tolaj-Avdiu, Miloreta, additional, Jarraya, Faical, additional, Nordio, Maurizio, additional, Ziginskiene, Edita, additional, Massy, Ziad A, additional, and Jager, Kitty J, additional

Published
2020
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