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Purpose: We describe an adolescent girl with Stage 1 Ewing's tumor and localized papillary adenocarcinoma of the thyroid gland, a previously unreported association., Patients and Methods: A 14-year-old girl with right axillary adenopathy was evaluated., Results: Ewing's tumor was diagnosed after a lymph node biopsy. A magnetic resonance imaging scan of the axilla, chest wall, and neck demonstrated a nodule in the right lobe of the thyroid gland. A biopsy revealed papillary adenocarcinoma., Conclusions: This is the first report of Ewing's tumor and carcinoma of the thyroid in the same patient.

Previous reports of the association between hematologic malignancies and germ cell tumors have been limited to patients with nonseminomatous tumors, exclusively of mediastinal origin. Among the various hematologic disorders, a large proportion have involved histiocytic tumors, either acute monocytic leukemia or malignant histiocytosis. We now report the first case of simultaneously occurring malignant histiocytosis and testicular embryonal carcinoma. The patient, an 18-year-old male, presented with hepatosplenomegaly due to malignant histiocytosis and was found on further evaluation to have a stage I testicular cancer consisting of teratocarcinoma with endodermal sinus elements. Despite aggressive chemotherapy, the patient died of malignant histiocytosis 6 months after the original diagnosis. The autopsy revealed widespread organ involvement with malignant histiocytosis and no evidence of residual germ cell tumor. This case demonstrates that germ cell tumors associated with hematologic malignancy do not arise solely in extragonadal sites.